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Gonadal fate in mammals is determined during embryogenesis and is actively maintained in adulthood. This study shows that E3-SUMO ligase activity of TRIM28 is required for ovarian identity maintenance and testicular-specific gene repression in mouse adult ovary; in its absence, ovarian granulosa cells transdifferentiate to Sertoli cells.

This article proposes a systematic review of the recent literature on the impacts of the deployment of autonomous vehicles through the lens of lifestyle changes that will modify our mobility practices. It discusses the main findings of the studies, analyzes their links with the foresight methods used by their authors, and identifies research gaps. Four components of lifestyles are considered: residential location, car ownership, activity patterns, and tourism. Particular attention is given to the diversity of the reviewed foresight approaches, to the way they complement one another in the construction of knowledge, and to their influence on the forecasts and the lessons learned. Our work shows a convergence of results across methods, especially for expected impacts on household location and car ownership, and the influence of the way autonomous vehicles are deployed. Our analysis also makes it possible to draw up a more comprehensive and nuanced picture of the anticipated changes in lifestyles, and the main sources of uncertainty. Finally, our work identifies several research gaps and avenues for future studies such as the impacts on job choices and tourism, the need for a better understanding of the links between the different deployment models for autonomous vehicles, and the need to explore more scenarios that are compatible with environmentally- and socially-oriented goals.

Abstract Background Perioperative chemotherapy and surgery are a standard of care for patients with resectable gastric or gastroesophageal junction (GEJ) adenocarcinoma. However, the prognosis remains poor for this population. The FLOT (fluorouracil, leucovorin, oxaliplatin, and docetaxel) regimen is considered as the new standard chemotherapy regimen for perioperative strategy, despite associated with a 5-year overall survival rate (OS) amounting 45% following radical surgery. Immunotherapy with antibodies that inhibit PD-1/ PD-L1 interaction has recently emerged as a new treatment option with promising and encouraging early trial results for patients with advanced or metastatic gastric or GEJ adenocarcinoma. Currently, no trials have investigated the impact of perioperative immunotherapy in combination with chemotherapy for resectable gastric or GEJ adenocarcinoma. Methods GASPAR trial is a multicenter open-label, nonrandomized, phase II trial to evaluate the efficacy and safety of Spartalizumab in combination with the FLOT regimen as perioperative treatment for resectable gastric or GEJ adenocarcinoma. The main endpoint is the proportion of patients with pathological complete regression (pCR) in the primary tumour after preoperative treatment. Systemic treatment will include a pre-operative neoadjuvant and a post-operative adjuvant treatment, during which FLOT regimen will be administered every two weeks for 4 cycles and Spartalizumab every four weeks for 2 cycles. For patients with confirmed tumor resectability on imaging assessment, surgery will be realized within 4–6 weeks after the last dose of preoperative chemotherapy. Post-operative systemic treatment will then be initiated within 4–10 weeks after surgery. Using a Simon’s two-stage design, up to 67 patients will be enrolled, including 23 in the first stage. Discussion Currently, no trials have investigated the impact of immunotherapy in combination with FLOT chemotherapy as perioperative treatment for resectable gastric or GEJ adenocarcinoma. Some studies have suggested a change in the tumor immune micro-environment following neoadjuvant chemotherapy in this setting, reinforcing the relevance to propose a phase II trial evaluating efficacy and safety of Spartalizumab in combination with perioperative chemotherapy, with the aim of improving treatment efficacy and survival outcomes. Trial registration NCT04736485, registered February, 3, 2021.

A net zero transition is likely to generate substantial and irreversible economic transformation. High-carbon industries and their related occupations will disappear, while new low-carbon industries and occupations will be created. In the aggregate, the impact of the transition on GDP and employment is commonly projected to be relatively moderate. However, such estimates hide drastic distributional issues that are sectorally and regionally concentrated. We use three sectorally detailed and regionally disaggregated macroeconomic models to explore the possible levels and impacts of structural change in a well below 2°C scenario. In addition to the expected decline in the carbon-intensive industries, we observe secondary impacts, particularly in the services sectors, that vary significantly between models. The risks entailed with structural change involve worsening economic disparity and societal division that could exacerbate existing socioeconomic and political polarisation. Impact assessments of decarbonisation should consider such distributional issues to avoid post-industrial decline and widening socioeconomic inequalities. [ABSTRACT FROM AUTHOR]

We study the impact of socioeconomic factors on two key parameters of epidemic dynamics. Specifically, we investigate a parameter capturing the rate of deceleration at the very start of an epidemic, and a parameter that reflects the pre-peak and post-peak dynamics at the turning point of an epidemic like coronavirus disease 2019 (COVID-19). We find two important results. The policies to fight COVID-19 (such as social distancing and containment) have been effective in reducing the overall number of new infections, because they influence not only the epidemic peaks, but also the speed of spread of the disease in its early stages. The second important result of our research concerns the role of healthcare infrastructure. They are just as effective as anti-COVID policies, not only in preventing an epidemic from spreading too quickly at the outset, but also in creating the desired dynamic around peaks: slow spreading, then rapid disappearance. [ABSTRACT FROM AUTHOR]

Global Integrated Assessment Models (IAMs) used to characterise mitigation pathways have very limited or no formal representation of lifestyles and lifestyle change. We demonstrate a novel approach to endogenously simulating low-carbon lifestyle heterogeneity and lifestyle change through soft-coupling with our new empirically-based LIFE model. Coupling LIFE to global IAMs enables dynamic simulation of distinctive lifestyle change contributions to targeted mitigation strategies. We set out the empirical basis of the LIFE model, the methodological steps for soft-coupling to a global IAM, and show results from a test application to the residential sector using the MESSAGEix-Buildings model. A first key insight is that coupling with the LIFE model introduces heterogeneous behaviour between ‘engaged’ types, who experience faster and higher reductions in final energy demand compared to ‘disengaged’ types. When we further simulate a widespread shift in normative values, this gap is closed. A second key insight is that drivers of lifestyle change, act differently across ‘Improve’ and ‘Avoid’ dimensions. The ‘disengaged’ types, characterised by lower incomes, are more highly responsive to energy saving ‘Avoid’ behaviours. Our approach demonstrates how improved understanding of lifestyle change dynamics and more realistic, empirically-based quantitative simulations in climate mitigation pathways enriches scientific and policy analysis of how to achieve Paris Climate Agreement goals.

Marine and coastal activities are closely interrelated, and conflicts among different sectors can undermine management and conservation objectives. Governance systems for fisheries, power generation, irrigation, aquaculture, marine biodiversity conservation, and other coastal and maritime activities are typically organized to manage conflicts within sectors, rather than across them. Based on the discussions around eight case studies presented at a workshop held in Brest in June 2019, this paper explores institutional approaches to move beyond managing conflicts within a sector. We primarily focus on cases where the groups and sectors involved are heterogeneous in terms of: the jurisdiction they fall under; their objectives; and the way they value ecosystem services. The paper first presents a synthesis of frameworks for understanding and managing cross-sectoral governance conflicts, drawing from social and natural sciences. We highlight commonalities but also conceptual differences across disciplines to address these issues. We then propose a novel analytical framework which we used to evaluate the eight case studies. Based on the main lessons learned from case studies, we then discuss the feasibility and key determinants of stakeholder collaboration as well as compensation and incentive schemes. The discussion concludes with future research needs to support policy development and inform integrated institutional regimes that consider the diversity of stakeholder interests and the potential benefits of cross-sectoral coordination.

This article seeks to estimate the relevance of the service economy applied to marine renewable energy projects. This study is based on stakeholder contributions in public debate in Saint-Brieuc offshore wind farm project (France). We seek to analyze stakeholder perspectives through an application of a textual analysis on contributions (cahiers d’acteurs). Textual analysis reveals two main results, the first one turns to social and economic question with the impact on the territory, in particularly the employment and the training. The second issue concerns the energy efficiency of marine renewable technologies. For each of these issues, the discussion try to give a perspective regard to service economy theory and discuss about the relevance of service economy application in marine renewable energy sector.