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2. Author Correction: Synaptic loss and its association with symptom severity in Parkinson’s disease

Author

Holmes, Sophie E., Honhar, Praveen, Tinaz, Sule, Naganawa, Mika, Hilmer, Ansel T., Gallezot, Jean-Dominique, Dias, Mark, Yang, Yanghong, Toyonaga, Takuya, Esterlis, Irina, Mecca, Adam, Van Dyck, Christopher, Henry, Shannan, Ropchan, Jim, Nabulsi, Nabeel, Louis, Elan D., Comley, Robert, Finnema, Sjoerd J., Carson, Richard E., and Matuskey, David

Published
2024
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4. The regional pattern of age-related synaptic loss in the human brain differs from gray matter volume loss: in vivo PET measurement with [11C]UCB-J

Author

Toyonaga, Takuya, Khattar, Nikkita, Wu, Yanjun, Lu, Yihuan, Naganawa, Mika, Gallezot, Jean-Dominique, Matuskey, David, Mecca, Adam P., Pittman, Brian, Dias, Mark, Nabulsi, Nabeel B., Finnema, Sjoerd J., Chen, Ming-Kai, Arnsten, Amy, Radhakrishnan, Rajiv, Skosnik, Patrick D., D’Souza, Deepak Cyril, Esterlis, Irina, Huang, Yiyun, van Dyck, Christopher H., and Carson, Richard E.

Published
2024
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8. Mapping neurotransmitter systems to the structural and functional organization of the human neocortex

Author

Hansen, Justine Y., Shafiei, Golia, Markello, Ross D., Smart, Kelly, Cox, Sylvia M. L., Nørgaard, Martin, Beliveau, Vincent, Wu, Yanjun, Gallezot, Jean-Dominique, Aumont, Étienne, Servaes, Stijn, Scala, Stephanie G., DuBois, Jonathan M., Wainstein, Gabriel, Bezgin, Gleb, Funck, Thomas, Schmitz, Taylor W., Spreng, R. Nathan, Galovic, Marian, Koepp, Matthias J., Duncan, John S., Coles, Jonathan P., Fryer, Tim D., Aigbirhio, Franklin I., McGinnity, Colm J., Hammers, Alexander, Soucy, Jean-Paul, Baillet, Sylvain, Guimond, Synthia, Hietala, Jarmo, Bedard, Marc-André, Leyton, Marco, Kobayashi, Eliane, Rosa-Neto, Pedro, Ganz, Melanie, Knudsen, Gitte M., Palomero-Gallagher, Nicola, Shine, James M., Carson, Richard E., Tuominen, Lauri, Dagher, Alain, and Misic, Bratislav

Published
2022
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12. Noninvasive quantification of [18F]SynVesT-1 binding using simplified reference tissue model 2.

Author

Naganawa, Mika, Gallezot, Jean-Dominique, Li, Songye, Nabulsi, Nabeel B., Henry, Shannan, Cai, Zhengxin, Matuskey, David, Huang, Yiyun, and Carson, Richard E.

Subjects
*POSITRON emission tomography, *SYNAPTIC vesicles, *STATISTICAL reliability, *ESTIMATION bias, *BLOOD sampling
Abstract

Purpose: [18F]SynVesT-1, a positron emission tomography (PET) radiotracer for the synaptic vesicle glycoprotein 2A (SV2A), demonstrates kinetics similar to [11C]UCB-J, with high brain uptake, fast kinetics fitting well with the one-tissue compartment (1TC) model, and excellent test-retest reproducibility. Challenges arise due to the similarity between k2 and (efflux rate of the reference region), when applying the simplified reference tissue model (SRTM) and related methods in [11C]UCB-J studies to accurately estimate . This study evaluated the suitability of these methods to estimate [18F]SynVesT-1 binding using centrum semiovale (CS) or cerebellum (CER) as reference regions. Method: Seven healthy participants underwent 120-min PET scans on the HRRT scanner with [18F]SynVesT-1. Six participants underwent test and retest scans. Arterial blood sampling and metabolite analysis provided input functions for the 1TC model, serving as the gold standard for kinetic parameters values. SRTM, coupled SRTM (SRTMC) and SRTM2 estimated were applied to estimate (ref: CS) and DVRCER(ref: CER) values. For SRTM2, the population average of was determined from the 1TC model applied to the reference region. Test-retest variability and minimum scan time were also calculated. Results: The 1TC k2 (1/min) values for CS and CER were 0.031 ± 0.004 and 0.021 ± 0.002, respectively. Although SRTMC was much higher than 1TC , SRTMC underestimated BPND(ref: CS) and DVRCER by an average of 3% and 1% across regions, respectively, due to similar bias in k2 and estimation. SRTM underestimated BPND(ref: CS) by an average of 3%, but with the CER as reference region, SRTM estimation was unstable and DVRCER underestimation varied by region (mean 10%). Using population average values, SRTM2 BPND and DVRCER showed the best agreement with 1TC estimates. Conclusion: Our findings support the use of population value in SRTM2 with [18F]SynVesT-1 for the estimation of or DVRCER, regardless of the choice of reference region. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Association of entorhinal cortical tau deposition and hippocampal synaptic density in older individuals with normal cognition and early Alzheimer's disease

Author

Mecca, Adam P., Chen, Ming-Kai, O'Dell, Ryan S., Naganawa, Mika, Toyonaga, Takuya, Godek, Tyler A., Harris, Joanna E., Bartlett, Hugh H., Zhao, Wenzhen, Banks, Emmie R., Ni, Gessica S., Rogers, Kelly, Gallezot, Jean Dominique, Ropchan, Jim, Emery, Paul R., Nabulsi, Nabeel B., Vander Wyk, Brent C., Arnsten, Amy F.T., Huang, Yiyun, Carson, Richard E., and van Dyck, Christopher H.

Published
2022
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15. Feasibility study of PET dynamic imaging of [18F]DHMT for quantification of reactive oxygen species in the myocardium of large animals

Author

Wu, Jing, Boutagy, Nabil E., Cai, Zhengxin, Lin, Shu-fei, Zheng, Ming-Qiang, Feher, Attila, Stendahl, John C., Kapinos, Michael, Gallezot, Jean-Dominique, Liu, Hui, Mulnix, Tim, Zhang, Wenjie, Lindemann, Marcel, Teng, Jo-ku, Miller, Edward J., Huang, Yiyun, Carson, Richard E., Sinusas, Albert J., and Liu, Chi

Published
2022
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16. PET-BIDS, an extension to the brain imaging data structure for positron emission tomography

Author

Norgaard, Martin, Matheson, Granville J., Hansen, Hanne D., Thomas, Adam, Searle, Graham, Rizzo, Gaia, Veronese, Mattia, Giacomel, Alessio, Yaqub, Maqsood, Tonietto, Matteo, Funck, Thomas, Gillman, Ashley, Boniface, Hugo, Routier, Alexandre, Dalenberg, Jelle R., Betthauser, Tobey, Feingold, Franklin, Markiewicz, Christopher J., Gorgolewski, Krzysztof J., Blair, Ross W., Appelhoff, Stefan, Gau, Remi, Salo, Taylor, Niso, Guiomar, Pernet, Cyril, Phillips, Christophe, Oostenveld, Robert, Gallezot, Jean-Dominique, Carson, Richard E., Knudsen, Gitte M., Innis, Robert B., and Ganz, Melanie

Published
2022
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18. Effects of Age and BMI on Histamine H3 Receptor Availability in Healthy Humans

Author

Yang, Yanghong, primary, Ibrahim, Waleed, additional, Gravel, Paul, additional, Pittman, Brian, additional, Hoye, Jocelyn, additional, Cool, Ryan, additional, Sadabad, Faranak Ebrahimian, additional, Pittenger, Christopher, additional, Gallezot, Jean-Dominique, additional, Carson, Richard E., additional, Huang, Henry, additional, Radhakrishnan, Rajiv, additional, and Matuskey, David, additional

Published
2024
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20. Measuring Synaptic Density and Dopamine Transporter Availability in Parkinson's Disease: A PET Imaging Study with 11C-UCB-J and 18F-FE-PE2I (P7-3.007)

Author

Saadabad, Faranak Ebrahimian, primary, Volpi, Tommaso, additional, Honhar, Praveen, additional, Naganawa, Mika, additional, Cayir, Salih, additional, Tinaz, Sule, additional, Gallezot, Jean-Dominique, additional, angarita, Gustavo, additional, Holmes, Sophie, additional, Carson, Richard, additional, Finnema, Sjoerd, additional, and Matuskey, David, additional

Published
2024
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22. Clinical correlates of dopamine transporter availability in cross-sectional and longitudinal studies with [18F]FE-PE2I PET: independent validation with new insights.

Author

Honhar, Praveen, Sadabad, Faranak Ebrahimian, Tinaz, Sule, Gallezot, Jean-Dominique, Dias, Mark, Naganawa, Mika, Yang, Yanghong, Henry, Shannan, Hillmer, Ansel T, Gao, Hong, Najafzadeh, Soheila, Comley, Robert, Nabulsi, Nabeel, Huang, Yiyun, Finnema, Sjoerd J, Carson, Richard E, and Matuskey, David

Published
2024
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23. Relationship between neuroimaging and cognition in frontotemporal dementia: An FDG‐PET and structural MRI study.

Author

Cayir, Salih, Volpi, Tommaso, Toyonaga, Takuya, Gallezot, Jean‐Dominique, Yang, Yanghong, Sadabad, Faranak Ebrahimian, Mulnix, Tim, Mecca, Adam P., Fesharaki‐Zadeh, Arman, and Matuskey, David

Subjects
MONTREAL Cognitive Assessment, GRAY matter (Nerve tissue), MAGNETIC resonance imaging, FRONTOTEMPORAL dementia, ALZHEIMER'S patients
Abstract

Background and Purpose: Frontotemporal dementia (FTD) is a clinically and pathologically heterogeneous neurodegenerative condition with a prevalence comparable to Alzheimer's disease for patients under 65 years of age. Limited studies have examined the association between cognition and neuroimaging in FTD using different imaging modalities. Methods: We examined the association of cognition using Montreal Cognitive Assessment (MoCA) with both gray matter (GM) volume and glucose metabolism using magnetic resonance imaging and fluorodeoxyglucose (FDG)‐PET in 21 patients diagnosed with FTD. Standardized uptake value ratio (SUVR) using the brainstem as a reference region was the primary outcome measure for FDG‐PET. Partial volume correction was applied to PET data to account for disease‐related atrophy. Results: Significant positive associations were found between whole‐cortex GM volume and MoCA scores (r = 0.46, p =.04). The association between whole‐cortex FDG SUVR and MoCA scores was not significant (r = 0.37, p =.09). GM volumes of the frontal cortex (r = 0.54, p =.01), caudate (r = 0.62, p<.01), and insula (r = 0.57, p<.01) were also significantly correlated with MoCA, as were SUVR values of the insula (r = 0.51, p =.02), thalamus (r = 0.48, p =.03), and posterior cingulate cortex (PCC) (r = 0.47, p =.03). Conclusions: Whole‐cortex atrophy is associated with cognitive dysfunction, and this association is larger than for whole‐cortex hypometabolism as measured with FDG‐PET. At the regional level, focal atrophy and/or hypometabolism in the frontal cortex, insula, PCC, thalamus, and caudate seem to be important for the decline of cognitive function in FTD. Furthermore, these results highlight how functional and structural changes may not overlap and might contribute to cognitive dysfunction in FTD in different ways. [ABSTRACT FROM AUTHOR]

Published
2024
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24. First-in-Human Study of 18F-SynVesT-2: An SV2A PET Imaging Probe with Fast Brain Kinetics and High Specific Binding.

Author

Drake, Lindsey R., Yanjun Wu, Naganawa, Mika, Asch, Ruth, Chao Zheng, Najafzadeh, Soheila, Pracitto, Richard, Lindemann, Marcel, Songye Li, Ropchan, Jim, Labaree, David, Emery, Paul R., Dias, Mark, Henry, Shannan, Nabulsi, Nabeel, Matuskey, David, Hillmer, Ansel T., Gallezot, Jean-Dominique, Carson, Richard E., and Zhengxin Cai

Published
2024
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26. First-in-Human Study of18F-SynVesT-2: An SV2A PET Imaging Probe with Fast Brain Kinetics and High Specific Binding

Author

Drake, Lindsey R., primary, Wu, Yanjun, additional, Naganawa, Mika, additional, Asch, Ruth, additional, Zheng, Chao, additional, Najafzadeh, Soheila, additional, Pracitto, Richard, additional, Lindemann, Marcel, additional, Li, Songye, additional, Ropchan, Jim, additional, Labaree, David, additional, Emery, Paul R., additional, Dias, Mark, additional, Henry, Shannan, additional, Nabulsi, Nabeel, additional, Matuskey, David, additional, Hillmer, Ansel T., additional, Gallezot, Jean-Dominique, additional, Carson, Richard E., additional, Cai, Zhengxin, additional, and Huang, Yiyun, additional

Published
2024
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31. Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice

Author

Baldan, Lissandra Castellan, Williams, Kyle A, Gallezot, Jean-Dominique, Pogorelov, Vladimir, Rapanelli, Maximiliano, Crowley, Michael, Anderson, George M, Loring, Erin, Gorczyca, Roxanne, Billingslea, Eileen, Wasylink, Suzanne, Panza, Kaitlyn E, Ercan-Sencicek, A Gulhan, Krusong, Kuakarun, Leventhal, Bennett L, Ohtsu, Hiroshi, Bloch, Michael H, Hughes, Zoë A, Krystal, John H, Mayes, Linda, de Araujo, Ivan, Ding, Yu-Shin, State, Matthew W, and Pittenger, Christopher

Subjects
Biological Psychology, Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Psychology, Genetics, Neurosciences, Brain Disorders, Neurodegenerative, Tourette Syndrome, 2.1 Biological and endogenous factors, Aetiology, Adolescent, Adult, Amphetamine, Animals, Brain, Child, Dopamine Agonists, Dopamine Antagonists, Exploratory Behavior, Female, Histidine Decarboxylase, Humans, Male, Maze Learning, Mice, Mice, Knockout, Middle Aged, Mutation, Oxazines, Raclopride, Radionuclide Imaging, Stereotyped Behavior, Time Factors, Tryptophan, Young Adult, Cognitive Sciences, Neurology & Neurosurgery, Biological psychology
Abstract

Tourette syndrome (TS) is characterized by tics, sensorimotor gating deficiencies, and abnormalities of cortico-basal ganglia circuits. A mutation in histidine decarboxylase (Hdc), the key enzyme for the biosynthesis of histamine (HA), has been implicated as a rare genetic cause. Hdc knockout mice exhibited potentiated tic-like stereotypies, recapitulating core phenomenology of TS; these were mitigated by the dopamine (DA) D2 antagonist haloperidol, a proven pharmacotherapy, and by HA infusion into the brain. Prepulse inhibition was impaired in both mice and humans carrying Hdc mutations. HA infusion reduced striatal DA levels; in Hdc knockout mice, striatal DA was increased and the DA-regulated immediate early gene Fos was upregulated. DA D2/D3 receptor binding was altered both in mice and in humans carrying the Hdc mutation. These data confirm histidine decarboxylase deficiency as a rare cause of TS and identify HA-DA interactions in the basal ganglia as an important locus of pathology.

Published
2014

32. The regional pattern of age-related synaptic loss in the human brain differs from gray matter volume loss: in vivo PET measurement with [11C]UCB-J

Author

Toyonaga, Takuya, primary, Khattar, Nikkita, additional, Wu, Yanjun, additional, Lu, Yihuan, additional, Naganawa, Mika, additional, Gallezot, Jean-Dominique, additional, Matuskey, David, additional, Mecca, Adam P., additional, Pittman, Brian, additional, Dias, Mark, additional, Nabulsi, Nabeel B., additional, Finnema, Sjoerd J., additional, Chen, Ming-Kai, additional, Arnsten, Amy, additional, Radhakrishnan, Rajiv, additional, Skosnik, Patrick D., additional, D’Souza, Deepak Cyril, additional, Esterlis, Irina, additional, Huang, Yiyun, additional, van Dyck, Christopher H., additional, and Carson, Richard E., additional

Published
2023
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38. The regional pattern of age-related synaptic loss in the human brain differs from gray matter volume loss: in vivo PET measurement with [11C]UCB-J.

Author

Toyonaga, Takuya, Khattar, Nikkita, Wu, Yanjun, Lu, Yihuan, Naganawa, Mika, Gallezot, Jean-Dominique, Matuskey, David, Mecca, Adam P., Pittman, Brian, Dias, Mark, Nabulsi, Nabeel B., Finnema, Sjoerd J., Chen, Ming-Kai, Arnsten, Amy, Radhakrishnan, Rajiv, Skosnik, Patrick D., D'Souza, Deepak Cyril, Esterlis, Irina, Huang, Yiyun, and van Dyck, Christopher H.

Subjects
VOXEL-based morphometry, GRAY matter (Nerve tissue), POSITRON emission tomography, NEURAL circuitry, MAGNETIC resonance imaging, SYNAPTIC vesicles, NERVE endings
Abstract

Purpose: Aging is a major societal concern due to age-related functional losses. Synapses are crucial components of neural circuits, and synaptic density could be a sensitive biomarker to evaluate brain function. [11C]UCB-J is a positron emission tomography (PET) ligand targeting synaptic vesicle glycoprotein 2A (SV2A), which can be used to evaluate brain synaptic density in vivo. Methods: We evaluated age-related changes in gray matter synaptic density, volume, and blood flow using [11C]UCB-J PET and magnetic resonance imaging (MRI) in a wide age range of 80 cognitive normal subjects (21–83 years old). Partial volume correction was applied to the PET data. Results: Significant age-related decreases were found in 13, two, and nine brain regions for volume, synaptic density, and blood flow, respectively. The prefrontal cortex showed the largest volume decline (4.9% reduction per decade: RPD), while the synaptic density loss was largest in the caudate (3.6% RPD) and medial occipital cortex (3.4% RPD). The reductions in caudate are consistent with previous SV2A PET studies and likely reflect that caudate is the site of nerve terminals for multiple major tracts that undergo substantial age-related neurodegeneration. There was a non-significant negative relationship between volume and synaptic density reductions in 16 gray matter regions. Conclusion: MRI and [11]C-UCB-J PET showed age-related decreases of gray matter volume, synaptic density, and blood flow; however, the regional patterns of the reductions in volume and SV2A binding were different. Those patterns suggest that MR-based measures of GM volume may not be directly representative of synaptic density. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Supplementary Figure from [89Zr]ZrDFO-CR011 PET Correlates with Response to Glycoprotein Nonmetastatic Melanoma B–targeted Therapy in Triple-negative Breast Cancer

Author

Lee, Supum, primary, Cavaliere, Alessandra, primary, Gallezot, Jean-Dominique, primary, Keler, Tibor, primary, Michelhaugh, Sharon K., primary, Belitzky, Erika, primary, Liu, Michael, primary, Mulnix, Tim, primary, Maher, Stephen E., primary, Bothwell, Alfred L.M., primary, Li, Fangyong, primary, Phadke, Manali, primary, Mittal, Sandeep, primary, and Marquez-Nostra, Bernadette, primary

Published
2023
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41. Supplementary Data from [89Zr]ZrDFO-CR011 PET Correlates with Response to Glycoprotein Nonmetastatic Melanoma B–targeted Therapy in Triple-negative Breast Cancer

Author

Lee, Supum, primary, Cavaliere, Alessandra, primary, Gallezot, Jean-Dominique, primary, Keler, Tibor, primary, Michelhaugh, Sharon K., primary, Belitzky, Erika, primary, Liu, Michael, primary, Mulnix, Tim, primary, Maher, Stephen E., primary, Bothwell, Alfred L.M., primary, Li, Fangyong, primary, Phadke, Manali, primary, Mittal, Sandeep, primary, and Marquez-Nostra, Bernadette, primary

Published
2023
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42. Supplementary Table from [89Zr]ZrDFO-CR011 PET Correlates with Response to Glycoprotein Nonmetastatic Melanoma B–targeted Therapy in Triple-negative Breast Cancer

Author

Lee, Supum, primary, Cavaliere, Alessandra, primary, Gallezot, Jean-Dominique, primary, Keler, Tibor, primary, Michelhaugh, Sharon K., primary, Belitzky, Erika, primary, Liu, Michael, primary, Mulnix, Tim, primary, Maher, Stephen E., primary, Bothwell, Alfred L.M., primary, Li, Fangyong, primary, Phadke, Manali, primary, Mittal, Sandeep, primary, and Marquez-Nostra, Bernadette, primary

Published
2023
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50. Neurotransmitter transporter occupancy following administration of centanafadine sustained-release tablets: A phase 1 study in healthy male adults

Author

Matuskey, David, primary, Gallezot, Jean-Dominique, additional, Nabulsi, Nabeel, additional, Henry, Shannan, additional, Torres, Kristen, additional, Dias, Mark, additional, Angarita, Gustavo A, additional, Huang, Yiyun, additional, Shoaf, Susan E, additional, Carson, Richard E, additional, and Mehrotra, Shailly, additional

Published
2022
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