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488 results on '"Galletti Claudio"'

1. A Poisson generalized linear model application to disentangle the effects of various parameters on neurophysiological discharges

Author

Vaccari Francesco Edoardo, Diomedi Stefano, Filippini Matteo, Galletti Claudio, and Fattori Patrizia

Subjects
Bioinformatics, Single Cell, Model Organisms, Neuroscience, Science (General), Q1-390
Abstract

Summary: The protocol provides an extensive guide to apply the generalized linear model framework to neurophysiological recordings. This flexible technique can be adapted to test and quantify the contributions of many different parameters (e.g., kinematics, target position, choice, reward) on neural activity. To weight the influence of each parameter, we developed an intuitive metric (“w-value”) that can be used to build a “functional fingerprint” characteristic for each neuron. We also provide suggestions to extract complementary useful information from the method.For complete details on the use and execution of this protocol, please refer to Diomedi et al. (2020).

Published
2021
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8. Modulation of reaching by spatial attention.

Author

Breveglieri, Rossella, Brandolani, Riccardo, Diomedi, Stefano, Lappe, Markus, Galletti, Claudio, and Fattori, Patrizia

Subjects
UNILATERAL neglect, PRINCIPAL components analysis, NEUROLOGICAL disorders, GOAL (Psychology), ATTENTION
Abstract

Attention is needed to perform goal-directed vision-guided movements. We investigated whether the direction of covert attention modulates movement outcomes and dynamics. Right-handed and left-handed volunteers attended to a spatial location while planning a reach toward the same hemifield, the opposite one, or planned a reach without constraining attention. We measured behavioral variables as outcomes of ipsilateral and contralateral reaching and the tangling of behavioral trajectories obtained through principal component analysis as a measure of the dynamics of motor control. We found that the direction of covert attention had significant effects on the dynamics of motor control, specifically during contralateral reaching. Data suggest that motor control was more feedback-driven when attention was directed leftward than when attention was directed rightward or when it was not constrained, irrespectively of handedness. These results may help to better understand the neural bases of asymmetrical neurological diseases like hemispatial neglect. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Neural sensitivity to translational self‐ and object‐motion velocities.

Author

Sulpizio, Valentina, von Gal, Alessandro, Galati, Gaspare, Fattori, Patrizia, Galletti, Claudio, and Pitzalis, Sabrina

Subjects
FUNCTIONAL magnetic resonance imaging, CINGULATE cortex, RELATIVE motion, RELATIVE velocity, OPTICAL flow
Abstract

The ability to detect and assess world‐relative object‐motion is a critical computation performed by the visual system. This computation, however, is greatly complicated by the observer's movements, which generate a global pattern of motion on the observer's retina. How the visual system implements this computation is poorly understood. Since we are potentially able to detect a moving object if its motion differs in velocity (or direction) from the expected optic flow generated by our own motion, here we manipulated the relative motion velocity between the observer and the object within a stationary scene as a strategy to test how the brain accomplishes object‐motion detection. Specifically, we tested the neural sensitivity of brain regions that are known to respond to egomotion‐compatible visual motion (i.e., egomotion areas: cingulate sulcus visual area, posterior cingulate sulcus area, posterior insular cortex [PIC], V6+, V3A, IPSmot/VIP, and MT+) to a combination of different velocities of visually induced translational self‐ and object‐motion within a virtual scene while participants were instructed to detect object‐motion. To this aim, we combined individual surface‐based brain mapping, task‐evoked activity by functional magnetic resonance imaging, and parametric and representational similarity analyses. We found that all the egomotion regions (except area PIC) responded to all the possible combinations of self‐ and object‐motion and were modulated by the self‐motion velocity. Interestingly, we found that, among all the egomotion areas, only MT+, V6+, and V3A were further modulated by object‐motion velocities, hence reflecting their possible role in discriminating between distinct velocities of self‐ and object‐motion. We suggest that these egomotion regions may be involved in the complex computation required for detecting scene‐relative object‐motion during self‐motion. [ABSTRACT FROM AUTHOR]

Published
2024
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47. Differential visuomotor and somatosensory claustral inputs to macaque medial posterior parietal cortex

Author

Gamberini, Michela, primary, Passarelli, Lauretta, additional, Impieri, Daniele, additional, Montanari, Giulia, additional, Diomedi, Stefano, additional, Worthty, Katrina H., additional, Burman, Kathleen J., additional, Reser, David H., additional, Fattori, Patrizia, additional, Bakola, Sophia, additional, Rosa, Marcello G. P., additional, and Galletti, Claudio, additional

Published
2021
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49. Endoscopic mucosal resection of a large inflammatory fibroid polyp (Vanek’s tumor): a case report

Author

Buda, Carmelo, Garipoli, Claudia, Penna, Giuseppa, D'Aquino, Antonio, Galletti, Claudio, Facciola', Alessio, and Fedele, Francesco

Subjects
Male, Endoscopic Mucosal Resection, Leiomyoma, Biopsy, Case Report, inflammatory fibroid polyp, inflammatory fibroid polyp, endoscopic mucosal resection, PDGFRA, BRAF, CD34, digestive system diseases, BRAF, PDGFRA, Polyps, Mutation, Humans, CD34, Aged
Abstract

Vanek’s Tumor (inflammatory fibroid polyp) is a rare benign mesenchymal lesion occurring throughout the digestive tract. Classical Vanek’s tumor (“gastric”) contains concentric formations of proliferating spindle cells, which are CD34 positive. Atypical-inflammatory pseudotumor-like Vanek’s tumor (“intestinal”) lacks concentric formations and is CD34 negative. A 70-years-old man patient presented during hematochemical routine tests, sideropenic anemia and leukopiastrinosis. The patient performed osteomyelitis biopsy and esophagogastroduodenoscopy (EGD) showing a gastric wall with nodular appearance and, in antrum pre-pyloric, a polypoid pedunculated lesion, measuring approximately 3 cm in diameter, surrounded by hyperemic mucosa. The lesion then was removed by en bloc endoscopic mucosal resection (EMR) and histo-morphological, immune-cytochemical and biomolecular evaluations were performed. The data were compatible with a benign polyp fibroid inflammatory (Vanek’s Tumor). The results of this study suggest that endoscopic mucosal resection is a safe and efficacy solution for the resection of these gastrointestinal polyps and the two morphological patterns of Vanek’s tumor more probably represent only variants of one type of tumor than two different lesions. BRAF mutations were not shown growth PDGFRA wild-type Vanek’s tumor. (www.actabiomedica.it)

Published
2021

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