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Background and Aims: Hypercholesterolemia and oxidative stress are two of the most important risk factors for atherosclerosis. The aim of the present work was to evaluate mandarin (Citrus reticulata) peel oil (MPO) in cholesterol metabolism and lipid synthesis, and its antioxidant capacity., Methods and Results: Incubation of hepatic HepG2 cells with MPO (15-60 μL/L) reduced cholesterogenesis and saponifiable lipid synthesis, demonstrated by [ 14 C]acetate radioactivity assays. These effects were associated with a decrease in a post-squalene reaction of the mevalonate pathway. Molecular docking analyses were carried out using three different scoring functions to examine the cholesterol-lowering property of all the components of MPO against lanosterol synthase. Docking simulations proposed that minor components of MPO monoterpenes, like alpha-farnesene and neryl acetate, as well the major component, limonene and its metabolites, could be partly responsible for the inhibitory effects observed in culture assays. MPO also decreased RAW 264.7 foam cell lipid storage and its CD36 expression, and prevented low-density lipoprotein (LDL) lipid peroxidation., Conclusion: These results may imply a potential role of MPO in preventing atherosclerosis by a mechanism involving inhibition of lipid synthesis and storage and the decrease of LDL lipid peroxidation., Competing Interests: Declaration of Competing Interest The authors declare no conflicts of interest., (Copyright © 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.)

Speech unfolds over time, and the cues for even a single phoneme are rarely available simultaneously. Consequently, to recognize a single phoneme, listeners must integrate material over several hundred milliseconds. Prior work contrasts two accounts: (a) a memory buffer account in which listeners accumulate auditory information in memory and only access higher level representations (i.e., lexical representations) when sufficient information has arrived; and (b) an immediate integration scheme in which lexical representations can be partially activated on the basis of early cues and then updated when more information arises. These studies have uniformly shown evidence for immediate integration for a variety of phonetic distinctions. We attempted to extend this to fricatives, a class of speech sounds which requires not only temporal integration of asynchronous cues (the frication, followed by the formant transitions 150-350 ms later), but also integration across different frequency bands and compensation for contextual factors like coarticulation. Eye movements in the visual world paradigm showed clear evidence for a memory buffer. Results were replicated in five experiments, ruling out methodological factors and tying the release of the buffer to the onset of the vowel. These findings support a general auditory account for speech by suggesting that the acoustic nature of particular speech sounds may have large effects on how they are processed. It also has major implications for theories of auditory and speech perception by raising the possibility of an encapsulated memory buffer in early auditory processing., (© 2019 Cognitive Science Society, Inc.)

Recent work has demonstrated that the addition of multiple talkers during habituation improves 14-month-olds' performance in the switch task (Rost & McMurray, 2009). While the authors suggest that this boost in performance is due to the increase in acoustic variability (Rost & McMurray, 2010), it is also possible that there is something crucial about the presence of multiple talkers that is driving this performance. To determine whether or not acoustic variability in and of itself is beneficial in early word learning tasks like the switch task, we tested 14-month-old infants in a version of the switch task using acoustically variable auditory stimuli produced by a single speaker. Results show that 14-month-olds are able to learn phonemically similar words within the switch task with increased acoustic variability and without the presence of multiple talkers.

Most research on infant speech categories has relied on measures of discrimination. Such work often employs categorical perception as a linking hypothesis to enable inferences about categorization on the basis of discrimination measures. However, a large number of studies with adults challenge the utility of categorical perception in describing adult speech perception, and this in turn calls into question how to interpret measures of infant speech discrimination. We propose here a parallel channels model of discrimination (built on Pisoni and Tash Perception & Psychophysics, 15(2), 285-290, 1974), which posits that both a noncategorical or veridical encoding of speech cues and category representations can simultaneously contribute to discrimination. This can thus produce categorical perception effects without positing any warping of the acoustic signal, but it also reframes how we think about infant discrimination and development. We test this model by conducting a quantitative review of 20 studies examining infants' discrimination of voice onset time contrasts. This review suggests that within-category discrimination is surprisingly prevalent even in classic studies and that, averaging across studies, discrimination is related to continuous acoustic distance. It also identifies several methodological factors that may mask our ability to see this. Finally, it suggests that infant discrimination may improve over development, contrary to commonly held notion of perceptual narrowing. These results are discussed in terms of theories of speech development that may require such continuous sensitivity.