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Viene presentato il caso di un paziente che ha sviluppato una dermatosi lichenoide da farmaci derivati delle tienopirimidine con azione di anticoagulanti orali

Viene presentato il caso clinico di una giovane donna che presenta tricodiscomi multipli a livello del tronco in assenza di altri segni clinici e strumentali che portino all'inquadramento in alcuna sindrome sottostante

Viene presentato il caso emblematico di un'anziana donna con problemi di incontinenza, presentante lesioni nodulari nell'area del pannolino. La diagnosi è stata di dermatosi erosiva papulonodulare.

A double-blind, placebo-controlled study was carried out in 40 out-patients with endoscopically confirmed hypertrophic or erosive gastritis, without ulcer, to assess the effectiveness and tolerance of treatment with equine antisera (antidiencephalon and anti-stomach tissue). Patients were assigned at random to receive a single dose in suppository form on 2 days a week for 6 weeks of both antisera (anti-diencephalon on Days 1 and 4, anti-stomach tissue on Days 2 and 5) or placebo (saline solution). No other anti-ulcer treatment was allowed except standard antacid tablets, the consumption of which was recorded and used as an evaluation parameter. Endoscopy, haematology and haematochemistry were performed before and after treatment; symptoms (daytime and night-time pain, heartburn and dyspepsia) and possible adverse reactions were scored 0 to 4 in order of increasing severity before treatment and after 1, 2, 4 and 6 weeks. Five patients in the placebo group had to be withdrawn from the trial at the second week because of therapeutic failure. This proportion was significantly in favour of the antisera group, as was the proportion of patients endoscopically healed and the extent and rate of symptomatic improvement. Concomitant antacid consumption rapidly and significantly decreased in the antisera but not in the placebo group. Signs of intolerance were not observed with either treatment, nor were there any significant alterations in haematology or haematochemistry. In particular, the immune titre of patients did not increase after treatment, thus indicating that the administered heterologous proteins did not elicit an immunization of the patients against horse protein.(ABSTRACT TRUNCATED AT 250 WORDS)

SummaryA double-blind trial was carried out in 30 patients with peptic ulcers to assess the effects of treatment with a gastrin-receptor antagonist, proglumide, compared with a histamine H2-blocker, cimetidine. Patients received either 1200 mg proglumide or 1200 mg cimetidine per day for 28 days. The results showed that both drugs significantly reduced clinical symptoms and gastric secretion. In patients treated with cimetidine, there was a significant increase in blood gastrin levels and marked hypertrophy and hyperplasia of the antral mucosa was observed in almost all patients. No such changes were found in the patients treated with proglumide.

Viene presentato il caso clinico di una paziente con una reazione vescico-bollosa a livello acrale. Tale affezione risulta identificabile in una variante localizzata di pemfigoide bolloso

Although Malassezia yeasts are a part of the normal microflora, under certain conditions they can cause superficial skin infection, such as pityriasis versicolor (PV) and Malassezia folliculitis. Moreover the yeasts of the genus Malassezia have been associated with seborrheic dermatitis and dandruff, atopic dermatitis, psoriasis, and, less commonly, with confluent and reticulated papillomatosis, onychomycosis, and transient acantholytic dermatosis. The study of the clinical role of Malassezia species has been surrounded by controversy due to the relative difficulty in isolation, cultivation, and identification. This review focuses on the clinical, mycologic, and immunologic aspects of the various skin diseases associated with Malassezia. Moreover, since there exists little information about the epidemiology and ecology of Malassezia species in the Italian population and the clinical significance of these species is not fully distinguished, we will report data about a study we carried out. The aim of our study was the isolation and the identification of Malassezia species in PV-affected skin and non-affected skin in patients with PV and in clinically healthy individuals without any Malassezia associated skin disease.

Thirty-nine adult out-patients with dyspepsia and endoscopically proven gastritis and/or duodenitis without ulcer, completed a double-blind, placebo controlled, 8-week clinical trial of either Acidrine® (twenty-one patients) or placebo (eighteen patients), at a daily dosage of 2 tablets t.i.d. Treatment with Acidrine resulted in a significant improvement in symptoms and in the endoscopic appearance of the gastritis and duodenitis when compared with placebo.

A prospective, single-blind study was carried out in 30 patients with obstructive peripheral artery disease to investigate the haemorheological properties of fructose-1,6-diphosphate (FDP). Patients were allocated at random to receive 7 to 10-days' treatment with either 10 g or 10% FDP twice daily or saline. Measurements were made on entry and at the end of treatment of whole blood and plasma viscosity, erythrocyte deformability and aggregation, and lower limb blood flow was evaluated by Doppler technique. FDP treatment was associated with a reduction in whole blood viscosity (24%) and red blood cell aggregation index (27%), and an improvement in red blood cell deformability (42%) (p less than 0.01). No significant changes were observed in the control group. Plasma viscosity did not change in either treatment group. Limb blood flow increased (p less than 0.05) only in patients treated with FDP; the improvement was more pronounced in the most severely affected side (30%). No untoward events were observed or reported in any of the patients studied.

A 58-year-old man was referred to our clinic with an 8-month history of red-brown nodules on the dorsal surface of his left hand. He reported that he collected fish in his home aquarium as a hobby. On this basis, a prior diagnosis of nontuberculous mycobacterial infection was made, but systemic clarithromycin was ineffective. The patient also reported a constant painful sensation, which worsened in the evening and after exposure to low temperatures. Dermatologic examination of the left hand revealed two large, tender, red-brown skin nodules on the extensor surfaces of the second and third metacarpophalangeal joint, one of which was partially covered by a hematic crust …

A 65-year-old neglected man was referred to our clinic with a 10-month history of multiple both isolated and confluent pigmented nodular lesions, which increased progressively in number and size involving almost all the right leg and the lower abdomen (Figure 1). Moreover, clinical examination revealed a marked enlargement of right inguinal lymph nodes. Three years before clinical presentation, the patient underwent electrocoagulation therapy …