114 results on '"Galella, Michael A."'
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2. Structure–activity relationship study of central pyridine-derived TYK2 JH2 inhibitors: Optimization of the PK profile through C4′ and C6 variations
3. Role of Self-Association and Supersaturation in Oral Absorption of a Poorly Soluble Weakly Basic Drug
4. Discovery of Heteroaryl Urea Isosteres for Formyl Peptide Receptor 2 Agonists
5. Identification of 6-hydroxy-5-phenyl sulfonylpyrimidin-4(1H)-one APJ receptor agonists
6. Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy
7. Annulation reaction enables the identification of an exocyclic amide tricyclic chemotype as retinoic acid Receptor-Related orphan receptor gamma (RORγ/RORc) inverse agonists
8. Discovery of (3S,4S)-3-methyl-3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxyprop-2-yl)phenyl)pyrrolidines as novel RORγt inverse agonists
9. Scalable Asymmetric Synthesis of the All Cis Triamino Cyclohexane Core of BMS-813160
10. Discovery of a Hydroxypyridinone APJ Receptor Agonist as a Clinical Candidate
11. Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTK
12. Scalable Asymmetric Synthesis of the All Cis Triamino Cyclohexane Core of BMS-813160.
13. Discovery and synthesis of tetrahydropyrimidinedione-4-carboxamides as endothelial lipase inhibitors
14. Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (RORγ/RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity
15. Biphenyl Acid Derivatives as APJ Receptor Agonists
16. One-Step Diastereoselective Pyrrolidine Synthesis Using a Sulfinamide Annulating Reagent
17. Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton’s Tyrosine Kinase (BTK)
18. Scalable Asymmetric Synthesis of the All CisTriamino Cyclohexane Core of BMS-813160
19. Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORγt Inverse Agonists
20. Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis
21. Use of a Conformational-Switching Mechanism to Modulate Exposed Polarity: Discovery of CCR2 Antagonist BMS-741672
22. [2.2.1]-Bicyclic sultams as potent androgen receptor antagonists
23. Sulfonylated Benzothiazoles as Inhibitors of Endothelial Lipase
24. Evolution of a Scale-Up Synthesis to a Potent GluN2B Inhibitor and Its Prodrug
25. Discovery and synthesis of cyclohexenyl derivatives as modulators of CC chemokine receptor 2 activity
26. Protected Chloroethyl and Chloropropyl Amines as Conformationally Unrestricted Annulating Reagents
27. To solvate or not to solvate? A crystallographic evaluation of the isostructural solvated and non-solvated crystal forms of an active pharmaceutical ingredient
28. One-Step Diastereoselective Pyrrolidine Synthesis Using a Sulfinamide Annulating Reagent.
29. Synthesis and evaluation of carbamoylmethylene linked prodrugs of BMS-582949, a clinical p38α inhibitor
30. Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton’s Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers
31. Discovery and Structure–Activity Relationship (SAR) of a Series of Ethanolamine-Based Direct-Acting Agonists of Sphingosine-1-phosphate (S1P1)
32. Improving the Pharmacokinetic and CYP Inhibition Profiles of Azaxanthene-Based Glucocorticoid Receptor Modulators—Identification of (S)-5-(2-(9-Fluoro-2-(4-(2-hydroxypropan-2-yl)phenyl)-5H-chromeno[2,3-b]pyridin-5-yl)-2-methylpropanamido)-N-(tetrahydro-2H-pyran-4-yl)-1,3,4-thiadiazole-2-carboxamide (BMS-341)
33. Novel tricyclic inhibitors of IKK2: Discovery and SAR leading to the identification of 2-methoxy- N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-7-yl)pyridin-2-yl)methyl)acetamide (BMS-066)
34. Protected Chloroethyl and Chloropropyl Amines as Conformationally Unrestricted Annulating Reagents.
35. Discovery and Structure-Activity Relationship (SAR) of a Series of Ethanolamine-Based Direct-Acting Agonists of Sphingosine-1-phosphate (S1P1).
36. Identification and optimization of a novel series of [2.2.1]-oxabicyclo imide-based androgen receptor antagonists
37. Understanding the Origins of Conformational Disorder in the Crystalline Polymorphs of Irbesartan
38. Diphenylpyridylethanamine (DPPE) Derivatives as Cholesteryl Ester Transfer Protein (CETP) Inhibitors
39. ChemInform Abstract: Novel Two-Step, One-Pot Synthesis of Primary Acylureas.
40. Novel two-step, one-pot synthesis of primary acylureas
41. Discovery of Potent and Muscle Selective Androgen Receptor Modulators through Scaffold Modifications
42. One‐Pot Synthesis and Conformational Features of N,N′‐Disubstituted Ketene Aminals.
43. One-Pot Synthesis and Conformational Features of N,N‘-Disubstituted Ketene Aminals
44. Diphenylpyridylethanamine(DPPE) Derivatives as Cholesteryl Ester Transfer Protein (CETP) Inhibitors.
45. One-Pot Synthesis and Conformational Features of N,N'-Disubstituted Ketene Aminals.
46. Triazolopyridine 11-beta Hydroxysteroid Dehydrogenase Type I Inhibitors
47. Triazolopyridine 11-beta Hydroxysteroid Dehydrogenase Type I Inhibitors
48. Biphenyl AcidDerivatives as APJ Receptor Agonists
49. Discovery and Structure-Activity Relationship (SAR) of a Series of Ethanolamine-Based Direct-Acting Agonists of Sphingosine-1-phosphate (S1P1).
50. Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy.
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