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3. Cognition, function, and prevalent dementia in centenarians and near‐centenarians: An individual participant data (IPD) meta‐analysis of 18 studies

Author

Leung, Yvonne, Barzilai, Nir, Batko‐Szwaczka, Agnieszka, Beker, Nina, Boerner, Kathrin, Brayne, Carol, Brodaty, Henry, Cheung, Karen Siu‐Lan, Corrada, María M, Crawford, John D, Galbussera, Alessia A, Gondo, Yasuyuki, Holstege, Henne, Hulsman, Marc, Ishioka, Yoshiko Lily, Jopp, Daniela, Kawas, Claudia H, Kaye, Jeff, Kochan, Nicole A, Lau, Bobo Hi‐Po, Lipnicki, Darren M, Lo, Jessica W, Lucca, Ugo, Makkar, Steve R, Marcon, Gabriella, Martin, Peter, Meguro, Kenichi, Milman, Sofiya, Poon, Leonard W, Recchia, Angela, Ribeiro, Oscar, Riva, Emma, Rott, Christoph, Sikkes, Sietske AM, Skoog, Ingmar, Stephan, Blossom, Szewieczek, Jan, Teixeira, Laetitia, Tettamanti, Mauro, Wilczyński, Krzysztof, and Sachdev, Perminder

Subjects
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Clinical Research, Behavioral and Social Science, Dementia, Prevention, Brain Disorders, Acquired Cognitive Impairment, Neurodegenerative, Aging, Neurological, Quality Education, Male, Aged, 80 and over, Humans, Female, Centenarians, Cognition, Body Mass Index, Educational Status, centenarians, dementia, education, exceptional longevity, prevalence, risk factors, Geriatrics, Clinical sciences, Biological psychology
Abstract

IntroductionThere are limited data on prevalence of dementia in centenarians and near-centenarians (C/NC), its determinants, and whether the risk of dementia continues to rise beyond 100.MethodsParticipant-level data were obtained from 18 community-based studies (N = 4427) in 11 countries that included individuals ≥95 years. A harmonization protocol was applied to cognitive and functional impairments, and a meta-analysis was performed.ResultsThe mean age was 98.3 years (SD = 2.67); 79% were women. After adjusting for age, sex, and education, dementia prevalence was 53.2% in women and 45.5% in men, with risk continuing to increase with age. Education (OR 0.95;0.92-0.98) was protective, as was hypertension (odds ratio [OR] 0.51;0.35-0.74) in five studies. Dementia was not associated with diabetes, vision and hearing impairments, smoking, and body mass index (BMI).DiscussionAmong the exceptional old, dementia prevalence remains higher in the older participants. Education was protective against dementia, but other factors for dementia-free survival in C/NC remain to be understood.

Published
2023

4. Clinical characteristics and outcomes of vaccinated patients hospitalised with SARS-CoV-2 breakthrough infection: Multi-IPV, a multicentre study in Northern Italy

Author

Andrea Lombardi, Simone Villa, Marta Colaneri, Giovanni Scaglione, Francesca Bai, Benedetta Varisco, Valeria Bono, Antonio Vena, Chiara Dentone, Chiara Russo, Mauro Tettamanti, Giulia Renisi, Giulia Viero, Cecilia Azzarà, Marco Mantero, Flora Peyvandi, Matteo Bassetti, Giulia Marchetti, Antonio Muscatello, Alessandro Nobili, Andrea Gori, Alessandra Bandera, Silvano Bosari, Luigia Scudeller, Giuliana Fusetti, Laura Rusconi, Silvia Dell’Orto, Daniele Prati, Luca Valenti, Silvia Giovannelli, Maria Manunta, Giuseppe Lamorte, Francesca Ferarri, Andrea Gori., Davide Mangioni, Laura Alagna, Giorgio Bozzi, Andrea Lombardi., Riccardo Ungaro, Giuseppe Ancona, Marco Mussa, Bianca Veronica Mariani, Matteo Bolis, Nathalie Iannotti, Serena Ludovisi, Agnese Comelli, Simona Biscarini, Valeria Castelli, Emanuele Palomba, Marco Fava, Carlo Alberto Peri, Paola Saltini, Teresa Itri, Valentina Ferroni, Valeria Pastore, Roberta Massafra, Arianna Liparoti, Toussaint Muheberimana, Alessandro Giommi, Rosaria Bianco, Grazia Eliana Chitani, Chiara Bobbio, Irene De Matteis, Angelo Bianchi Bonomi, Roberta Gualtierotti, Barbara Ferrari, Raffaella Rossio, Nadia Boasi, Erica Pagliaro, Costanza Massimo, Michele De Caro, Andrea Giachi, Nicola Montano, Barbara Vigone, Chiara Bellocchi, Angelica Carandina, Elisa Fiorelli, Valerie Melli, Eleonora Tobaldini, Francesco Blasi, Stefano Aliberti, Maura Spotti, Leonardo Terranova, Sofia Misuraca, Alice D’Adda, Silvia Della Fiore, Marta Di Pasquale, Marco Mantero., Martina Contarini, Margherita Ori, Letizia Morlacchi, Valeria Rossetti, Andrea Gramegna, Maria Pappalettera, Mirta Cavallini, Agata Buscemi, Marco Vicenzi, Irena Rota, Giorgio Costantino, Monica Solbiati, Ludovico Furlan, Marta Mancarella, Giulia Colombo, Giorgio Colombo, Alice Fanin, Mariele Passarella, Valter Monzani, Ciro Canetta, Angelo Rovellini, Laura Barbetta, Filippo Billi, Christian Folli, Silvia Accordino, Diletta Maira, Cinzia Maria Hu, Irene Motta, Natalia Scaramellini, Anna Ludovica Fracanzani, Rosa Lombardi, Annalisa Cespiati, Matteo Cesari, Tiziano Lucchi, Marco Proietti, Laura Calcaterra, Clara Mandelli, Carlotta Coppola, Arturo Cerizza, Antonio Maria Pesenti, Giacomo Grasselli, Alessandro Galazzi, Alessandro Nobili., Igor Monti, Alessia Antonella Galbussera, Ernesto Crisafulli, Domenico Girelli, Alessio Maroccia, Daniele Gabbiani, Fabiana Busti, Alice Vianello, Marta Biondan, Filippo Sartori, Paola Faverio, Alberto Pesci, Stefano Zucchetti, Paolo Bonfanti, Marianna Rossi, Ilaria Beretta, Anna Spolti, Sergio Harari, Davide Elia, Roberto Cassandro, Antonella Caminati, Francesco Cipollone, Maria Teresa Guagnano, Damiano D’Ardes, Ilaria Rossi, Francesca Vezzani, Antonio Spanevello, Francesca Cherubino, Dina Visca, Marco Contoli, Alberto Papi, Luca Morandi, Nicholas Battistini, Guido Luigi Moreo, Pasqualina Iannuzzi, Daniele Fumagalla, and Sara Leone

Subjects
Vaccination, Breakthrough infection, SARS-COV-2, Infectious and parasitic diseases, RC109-216, Public aspects of medicine, RA1-1270
Abstract

Background: Despite the well-known efficacy of anti-COVID-19 vaccines in preventing morbidity and mortality, several vaccinated individuals are diagnosed with SARS-CoV-2 breakthrough infection, which might require hospitalisation. This multicentre, observational, and retrospective study aimed to investigate the clinical characteristics and outcomes of vaccinated vs. non-vaccinated patients, both hospitalised with SARS-CoV-2 infection in 3 major hospitals in Northern Italy. Methods: Data collection was retrospective, and paper and electronic medical records of adult patients with a diagnosed SARS-CoV-2 infection were pseudo-anonymised and analysed. Vaccinated and non-vaccinated individuals were manually paired, using a predetermined matching criterion (similar age, gender, and date of hospitalisation). Demographic, clinical, treatment, and outcome data were compared between groups differing by vaccination status using Pearson’s Chi-square and Mann-Whitney tests. Moreover, multiple logistic regression analyses were performed to assess the impact of vaccination status on ICU admission or intra-hospital mortality. Results: Data from 360 patients were collected. Vaccinated patients presented with a higher prevalence of relevant comorbidities, like kidney replacement therapy or haematological malignancy, despite a milder clinical presentation at the first evaluation. Non-vaccinated patients required intensive care more often than their vaccinated counterparts (8.8% vs. 1.7%, p = 0.002). Contrariwise, no difference in intra-hospital mortality was observed between the two groups (19% vs. 20%, p = 0.853). These results were confirmed by multivariable logistic regressions, which showed that vaccination was significantly associated with decreased risk of ICU admission (aOR=0.172, 95%CI: 0.039–0.542, p = 0.007), but not of intra-hospital mortality (aOR=0.996, 95%CI: 0.582–1.703, p = 0.987). Conclusions: This study provides real-world data on vaccinated patients hospitalised with COVID-19 in Northern Italy. Our results suggest that COVID-19 vaccination has a protective role in individuals with higher risk profiles, especially regarding the need for ICU admission. These findings contribute to our understanding of SARS-CoV-2 infection outcomes among vaccinated individuals and emphasise the importance of vaccination in preventing severe disease, particularly in those countries with lower first-booster uptake rates.

Published
2024
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6. Correction: Italian adaptation of the Uniform Data Set Neuropsychological Test Battery (I‑UDSNB 1.0): development and normative data

Author

Conca, Francesca, Esposito, Valentina, Rundo, Francesco, Quaranta, Davide, Muscio, Cristina, Manenti, Rosa, Caruso, Giulia, Lucca, Ugo, Galbussera, Alessia Antonella, Di Tella, Sonia, Baglio, Francesca, L’Abbate, Federica, Canu, Elisa, Catania, Valentina, Filippi, Massimo, Mattavelli, Giulia, Poletti, Barbara, Silani, Vincenzo, Lodi, Raffaele, De Matteis, Maddalena, Maserati, Michelangelo Stanzani, Arighi, Andrea, Rotondo, Emanuela, Tanzilli, Antonio, Pace, Andrea, Garramone, Federica, Cavaliere, Carlo, Pardini, Matteo, Rizzetto, Cristiano, Sorbi, Sandro, Perri, Roberta, Tiraboschi, Pietro, Canessa, Nicola, Cotelli, Maria, Ferri, Raffaele, Weintraub, Sandra, Marra, Camillo, Tagliavini, Fabrizio, Catricalà, Eleonora, and Cappa, Stefano Francesco

Published
2023
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8. Clinical characteristics and outcomes of vaccinated patients hospitalised with SARS-CoV-2 breakthrough infection: Multi-IPV, a multicentre study in Northern Italy

Author

Bosari, Silvano, Scudeller, Luigia, Fusetti, Giuliana, Rusconi, Laura, Dell’Orto, Silvia, Prati, Daniele, Valenti, Luca, Giovannelli, Silvia, Manunta, Maria, Lamorte, Giuseppe, Ferarri, Francesca, Gori., Andrea, Bandera, Alessandra, Muscatello, Antonio, Mangioni, Davide, Alagna, Laura, Bozzi, Giorgio, Lombardi., Andrea, Ungaro, Riccardo, Ancona, Giuseppe, Mussa, Marco, Mariani, Bianca Veronica, Bolis, Matteo, Iannotti, Nathalie, Ludovisi, Serena, Comelli, Agnese, Renisi, Giulia, Biscarini, Simona, Castelli, Valeria, Palomba, Emanuele, Fava, Marco, Peri, Carlo Alberto, Saltini, Paola, Viero, Giulia, Itri, Teresa, Ferroni, Valentina, Pastore, Valeria, Massafra, Roberta, Liparoti, Arianna, Muheberimana, Toussaint, Giommi, Alessandro, Bianco, Rosaria, Chitani, Grazia Eliana, Bobbio, Chiara, De Matteis, Irene, Bonomi, Angelo Bianchi, Peyvandi, Flora, Gualtierotti, Roberta, Ferrari, Barbara, Rossio, Raffaella, Boasi, Nadia, Pagliaro, Erica, Massimo, Costanza, De Caro, Michele, Giachi, Andrea, Montano, Nicola, Vigone, Barbara, Bellocchi, Chiara, Carandina, Angelica, Fiorelli, Elisa, Melli, Valerie, Tobaldini, Eleonora, Blasi, Francesco, Aliberti, Stefano, Spotti, Maura, Terranova, Leonardo, Misuraca, Sofia, D’Adda, Alice, Della Fiore, Silvia, Di Pasquale, Marta, Mantero., Marco, Contarini, Martina, Ori, Margherita, Morlacchi, Letizia, Rossetti, Valeria, Gramegna, Andrea, Pappalettera, Maria, Cavallini, Mirta, Buscemi, Agata, Vicenzi, Marco, Rota, Irena, Costantino, Giorgio, Solbiati, Monica, Furlan, Ludovico, Mancarella, Marta, Colombo, Giulia, Colombo, Giorgio, Fanin, Alice, Passarella, Mariele, Monzani, Valter, Canetta, Ciro, Rovellini, Angelo, Barbetta, Laura, Billi, Filippo, Folli, Christian, Accordino, Silvia, Maira, Diletta, Hu, Cinzia Maria, Motta, Irene, Scaramellini, Natalia, Fracanzani, Anna Ludovica, Lombardi, Rosa, Cespiati, Annalisa, Cesari, Matteo, Lucchi, Tiziano, Proietti, Marco, Calcaterra, Laura, Mandelli, Clara, Coppola, Carlotta, Cerizza, Arturo, Pesenti, Antonio Maria, Grasselli, Giacomo, Galazzi, Alessandro, Nobili., Alessandro, Tettamanti, Mauro, Monti, Igor, Galbussera, Alessia Antonella, Crisafulli, Ernesto, Girelli, Domenico, Maroccia, Alessio, Gabbiani, Daniele, Busti, Fabiana, Vianello, Alice, Biondan, Marta, Sartori, Filippo, Faverio, Paola, Pesci, Alberto, Zucchetti, Stefano, Bonfanti, Paolo, Rossi, Marianna, Beretta, Ilaria, Spolti, Anna, Harari, Sergio, Elia, Davide, Cassandro, Roberto, Caminati, Antonella, Cipollone, Francesco, Guagnano, Maria Teresa, D’Ardes, Damiano, Rossi, Ilaria, Vezzani, Francesca, Spanevello, Antonio, Cherubino, Francesca, Visca, Dina, Contoli, Marco, Papi, Alberto, Morandi, Luca, Battistini, Nicholas, Moreo, Guido Luigi, Iannuzzi, Pasqualina, Fumagalla, Daniele, Leone, Sara, Lombardi, Andrea, Villa, Simone, Colaneri, Marta, Scaglione, Giovanni, Bai, Francesca, Varisco, Benedetta, Bono, Valeria, Vena, Antonio, Dentone, Chiara, Russo, Chiara, Azzarà, Cecilia, Mantero, Marco, Bassetti, Matteo, Marchetti, Giulia, Nobili, Alessandro, and Gori, Andrea

Published
2024
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10. Clinical characteristics and outcomes of vaccinated patients hospitalised with SARS-CoV-2 breakthrough infection: Multi-IPV, a multicentre study in Northern Italy

Author

Lombardi, A, Villa, S, Colaneri, M, Scaglione, G, Bai, F, Varisco, B, Bono, V, Vena, A, Dentone, C, Russo, C, Tettamanti, M, Renisi, G, Viero, G, Azzarà, C, Mantero, M, Peyvandi, F, Bassetti, M, Marchetti, G, Muscatello, A, Nobili, A, Gori, A, Bandera, A, Bosari, S, Scudeller, L, Fusetti, G, Rusconi, L, Dell’Orto, S, Prati, D, Valenti, L, Giovannelli, S, Manunta, M, Lamorte, G, Ferarri, F, Gori., A, Mangioni, D, Alagna, L, Bozzi, G, Lombardi., A, Ungaro, R, Ancona, G, Mussa, M, Mariani, B, Bolis, M, Iannotti, N, Ludovisi, S, Comelli, A, Biscarini, S, Castelli, V, Palomba, E, Fava, M, Peri, C, Saltini, P, Itri, T, Ferroni, V, Pastore, V, Massafra, R, Liparoti, A, Muheberimana, T, Giommi, A, Bianco, R, Chitani, G, Bobbio, C, De Matteis, I, Bonomi, A, Gualtierotti, R, Ferrari, B, Rossio, R, Boasi, N, Pagliaro, E, Massimo, C, De Caro, M, Giachi, A, Montano, N, Vigone, B, Bellocchi, C, Carandina, A, Fiorelli, E, Melli, V, Tobaldini, E, Blasi, F, Aliberti, S, Spotti, M, Terranova, L, Misuraca, S, D’Adda, A, Della Fiore, S, Di Pasquale, M, Mantero., M, Contarini, M, Ori, M, Morlacchi, L, Rossetti, V, Gramegna, A, Pappalettera, M, Cavallini, M, Buscemi, A, Vicenzi, M, Rota, I, Costantino, G, Solbiati, M, Furlan, L, Mancarella, M, Colombo, G, Fanin, A, Passarella, M, Monzani, V, Canetta, C, Rovellini, A, Barbetta, L, Billi, F, Folli, C, Accordino, S, Maira, D, Hu, C, Motta, I, Scaramellini, N, Fracanzani, A, Lombardi, R, Cespiati, A, Cesari, M, Lucchi, T, Proietti, M, Calcaterra, L, Mandelli, C, Coppola, C, Cerizza, A, Pesenti, A, Grasselli, G, Galazzi, A, Nobili., A, Monti, I, Galbussera, A, Crisafulli, E, Girelli, D, Maroccia, A, Gabbiani, D, Busti, F, Vianello, A, Biondan, M, Sartori, F, Faverio, P, Pesci, A, Zucchetti, S, Bonfanti, P, Rossi, M, Beretta, I, Spolti, A, Harari, S, Elia, D, Cassandro, R, Caminati, A, Cipollone, F, Guagnano, M, D’Ardes, D, Rossi, I, Vezzani, F, Spanevello, A, Cherubino, F, Visca, D, Contoli, M, Papi, A, Morandi, L, Battistini, N, Moreo, G, Iannuzzi, P, Fumagalla, D, Leone, S, Lombardi, Andrea, Villa, Simone, Colaneri, Marta, Scaglione, Giovanni, Bai, Francesca, Varisco, Benedetta, Bono, Valeria, Vena, Antonio, Dentone, Chiara, Russo, Chiara, Tettamanti, Mauro, Renisi, Giulia, Viero, Giulia, Azzarà, Cecilia, Mantero, Marco, Peyvandi, Flora, Bassetti, Matteo, Marchetti, Giulia, Muscatello, Antonio, Nobili, Alessandro, Gori, Andrea, Bandera, Alessandra, Bosari, Silvano, Scudeller, Luigia, Fusetti, Giuliana, Rusconi, Laura, Dell’Orto, Silvia, Prati, Daniele, Valenti, Luca, Giovannelli, Silvia, Manunta, Maria, Lamorte, Giuseppe, Ferarri, Francesca, Gori. , Andrea, Mangioni, Davide, Alagna, Laura, Bozzi, Giorgio, Lombardi. , Andrea, Ungaro, Riccardo, Ancona, Giuseppe, Mussa, Marco, Mariani, Bianca Veronica, Bolis, Matteo, Iannotti, Nathalie, Ludovisi, Serena, Comelli, Agnese, Biscarini, Simona, Castelli, Valeria, Palomba, Emanuele, Fava, Marco, Peri, Carlo Alberto, Saltini, Paola, Itri, Teresa, Ferroni, Valentina, Pastore, Valeria, Massafra, Roberta, Liparoti, Arianna, Muheberimana, Toussaint, Giommi, Alessandro, Bianco, Rosaria, Chitani, Grazia Eliana, Bobbio, Chiara, De Matteis, Irene, Bonomi, Angelo Bianchi, Gualtierotti, Roberta, Ferrari, Barbara, Rossio, Raffaella, Boasi, Nadia, Pagliaro, Erica, Massimo, Costanza, De Caro, Michele, Giachi, Andrea, Montano, Nicola, Vigone, Barbara, Bellocchi, Chiara, Carandina, Angelica, Fiorelli, Elisa, Melli, Valerie, Tobaldini, Eleonora, Blasi, Francesco, Aliberti, Stefano, Spotti, Maura, Terranova, Leonardo, Misuraca, Sofia, D’Adda, Alice, Della Fiore, Silvia, Di Pasquale, Marta, Mantero. , Marco, Contarini, Martina, Ori, Margherita, Morlacchi, Letizia, Rossetti, Valeria, Gramegna, Andrea, Pappalettera, Maria, Cavallini, Mirta, Buscemi, Agata, Vicenzi, Marco, Rota, Irena, Costantino, Giorgio, Solbiati, Monica, Furlan, Ludovico, Mancarella, Marta, Colombo, Giulia, Colombo, Giorgio, Fanin, Alice, Passarella, Mariele, Monzani, Valter, Canetta, Ciro, Rovellini, Angelo, Barbetta, Laura, Billi, Filippo, Folli, Christian, Accordino, Silvia, Maira, Diletta, Hu, Cinzia Maria, Motta, Irene, Scaramellini, Natalia, Fracanzani, Anna Ludovica, Lombardi, Rosa, Cespiati, Annalisa, Cesari, Matteo, Lucchi, Tiziano, Proietti, Marco, Calcaterra, Laura, Mandelli, Clara, Coppola, Carlotta, Cerizza, Arturo, Pesenti, Antonio Maria, Grasselli, Giacomo, Galazzi, Alessandro, Nobili. , Alessandro, Monti, Igor, Galbussera, Alessia Antonella, Crisafulli, Ernesto, Girelli, Domenico, Maroccia, Alessio, Gabbiani, Daniele, Busti, Fabiana, Vianello, Alice, Biondan, Marta, Sartori, Filippo, Faverio, Paola, Pesci, Alberto, Zucchetti, Stefano, Bonfanti, Paolo, Rossi, Marianna, Beretta, Ilaria, Spolti, Anna, Harari, Sergio, Elia, Davide, Cassandro, Roberto, Caminati, Antonella, Cipollone, Francesco, Guagnano, Maria Teresa, D’Ardes, Damiano, Rossi, Ilaria, Vezzani, Francesca, Spanevello, Antonio, Cherubino, Francesca, Visca, Dina, Contoli, Marco, Papi, Alberto, Morandi, Luca, Battistini, Nicholas, Moreo, Guido Luigi, Iannuzzi, Pasqualina, Fumagalla, Daniele, Leone, Sara, Lombardi, A, Villa, S, Colaneri, M, Scaglione, G, Bai, F, Varisco, B, Bono, V, Vena, A, Dentone, C, Russo, C, Tettamanti, M, Renisi, G, Viero, G, Azzarà, C, Mantero, M, Peyvandi, F, Bassetti, M, Marchetti, G, Muscatello, A, Nobili, A, Gori, A, Bandera, A, Bosari, S, Scudeller, L, Fusetti, G, Rusconi, L, Dell’Orto, S, Prati, D, Valenti, L, Giovannelli, S, Manunta, M, Lamorte, G, Ferarri, F, Gori., A, Mangioni, D, Alagna, L, Bozzi, G, Lombardi., A, Ungaro, R, Ancona, G, Mussa, M, Mariani, B, Bolis, M, Iannotti, N, Ludovisi, S, Comelli, A, Biscarini, S, Castelli, V, Palomba, E, Fava, M, Peri, C, Saltini, P, Itri, T, Ferroni, V, Pastore, V, Massafra, R, Liparoti, A, Muheberimana, T, Giommi, A, Bianco, R, Chitani, G, Bobbio, C, De Matteis, I, Bonomi, A, Gualtierotti, R, Ferrari, B, Rossio, R, Boasi, N, Pagliaro, E, Massimo, C, De Caro, M, Giachi, A, Montano, N, Vigone, B, Bellocchi, C, Carandina, A, Fiorelli, E, Melli, V, Tobaldini, E, Blasi, F, Aliberti, S, Spotti, M, Terranova, L, Misuraca, S, D’Adda, A, Della Fiore, S, Di Pasquale, M, Mantero., M, Contarini, M, Ori, M, Morlacchi, L, Rossetti, V, Gramegna, A, Pappalettera, M, Cavallini, M, Buscemi, A, Vicenzi, M, Rota, I, Costantino, G, Solbiati, M, Furlan, L, Mancarella, M, Colombo, G, Fanin, A, Passarella, M, Monzani, V, Canetta, C, Rovellini, A, Barbetta, L, Billi, F, Folli, C, Accordino, S, Maira, D, Hu, C, Motta, I, Scaramellini, N, Fracanzani, A, Lombardi, R, Cespiati, A, Cesari, M, Lucchi, T, Proietti, M, Calcaterra, L, Mandelli, C, Coppola, C, Cerizza, A, Pesenti, A, Grasselli, G, Galazzi, A, Nobili., A, Monti, I, Galbussera, A, Crisafulli, E, Girelli, D, Maroccia, A, Gabbiani, D, Busti, F, Vianello, A, Biondan, M, Sartori, F, Faverio, P, Pesci, A, Zucchetti, S, Bonfanti, P, Rossi, M, Beretta, I, Spolti, A, Harari, S, Elia, D, Cassandro, R, Caminati, A, Cipollone, F, Guagnano, M, D’Ardes, D, Rossi, I, Vezzani, F, Spanevello, A, Cherubino, F, Visca, D, Contoli, M, Papi, A, Morandi, L, Battistini, N, Moreo, G, Iannuzzi, P, Fumagalla, D, Leone, S, Lombardi, Andrea, Villa, Simone, Colaneri, Marta, Scaglione, Giovanni, Bai, Francesca, Varisco, Benedetta, Bono, Valeria, Vena, Antonio, Dentone, Chiara, Russo, Chiara, Tettamanti, Mauro, Renisi, Giulia, Viero, Giulia, Azzarà, Cecilia, Mantero, Marco, Peyvandi, Flora, Bassetti, Matteo, Marchetti, Giulia, Muscatello, Antonio, Nobili, Alessandro, Gori, Andrea, Bandera, Alessandra, Bosari, Silvano, Scudeller, Luigia, Fusetti, Giuliana, Rusconi, Laura, Dell’Orto, Silvia, Prati, Daniele, Valenti, Luca, Giovannelli, Silvia, Manunta, Maria, Lamorte, Giuseppe, Ferarri, Francesca, Gori. , Andrea, Mangioni, Davide, Alagna, Laura, Bozzi, Giorgio, Lombardi. , Andrea, Ungaro, Riccardo, Ancona, Giuseppe, Mussa, Marco, Mariani, Bianca Veronica, Bolis, Matteo, Iannotti, Nathalie, Ludovisi, Serena, Comelli, Agnese, Biscarini, Simona, Castelli, Valeria, Palomba, Emanuele, Fava, Marco, Peri, Carlo Alberto, Saltini, Paola, Itri, Teresa, Ferroni, Valentina, Pastore, Valeria, Massafra, Roberta, Liparoti, Arianna, Muheberimana, Toussaint, Giommi, Alessandro, Bianco, Rosaria, Chitani, Grazia Eliana, Bobbio, Chiara, De Matteis, Irene, Bonomi, Angelo Bianchi, Gualtierotti, Roberta, Ferrari, Barbara, Rossio, Raffaella, Boasi, Nadia, Pagliaro, Erica, Massimo, Costanza, De Caro, Michele, Giachi, Andrea, Montano, Nicola, Vigone, Barbara, Bellocchi, Chiara, Carandina, Angelica, Fiorelli, Elisa, Melli, Valerie, Tobaldini, Eleonora, Blasi, Francesco, Aliberti, Stefano, Spotti, Maura, Terranova, Leonardo, Misuraca, Sofia, D’Adda, Alice, Della Fiore, Silvia, Di Pasquale, Marta, Mantero. , Marco, Contarini, Martina, Ori, Margherita, Morlacchi, Letizia, Rossetti, Valeria, Gramegna, Andrea, Pappalettera, Maria, Cavallini, Mirta, Buscemi, Agata, Vicenzi, Marco, Rota, Irena, Costantino, Giorgio, Solbiati, Monica, Furlan, Ludovico, Mancarella, Marta, Colombo, Giulia, Colombo, Giorgio, Fanin, Alice, Passarella, Mariele, Monzani, Valter, Canetta, Ciro, Rovellini, Angelo, Barbetta, Laura, Billi, Filippo, Folli, Christian, Accordino, Silvia, Maira, Diletta, Hu, Cinzia Maria, Motta, Irene, Scaramellini, Natalia, Fracanzani, Anna Ludovica, Lombardi, Rosa, Cespiati, Annalisa, Cesari, Matteo, Lucchi, Tiziano, Proietti, Marco, Calcaterra, Laura, Mandelli, Clara, Coppola, Carlotta, Cerizza, Arturo, Pesenti, Antonio Maria, Grasselli, Giacomo, Galazzi, Alessandro, Nobili. , Alessandro, Monti, Igor, Galbussera, Alessia Antonella, Crisafulli, Ernesto, Girelli, Domenico, Maroccia, Alessio, Gabbiani, Daniele, Busti, Fabiana, Vianello, Alice, Biondan, Marta, Sartori, Filippo, Faverio, Paola, Pesci, Alberto, Zucchetti, Stefano, Bonfanti, Paolo, Rossi, Marianna, Beretta, Ilaria, Spolti, Anna, Harari, Sergio, Elia, Davide, Cassandro, Roberto, Caminati, Antonella, Cipollone, Francesco, Guagnano, Maria Teresa, D’Ardes, Damiano, Rossi, Ilaria, Vezzani, Francesca, Spanevello, Antonio, Cherubino, Francesca, Visca, Dina, Contoli, Marco, Papi, Alberto, Morandi, Luca, Battistini, Nicholas, Moreo, Guido Luigi, Iannuzzi, Pasqualina, Fumagalla, Daniele, and Leone, Sara

Abstract

Background: Despite the well-known efficacy of anti-COVID-19 vaccines in preventing morbidity and mortality, several vaccinated individuals are diagnosed with SARS-CoV-2 breakthrough infection, which might require hospitalisation. This multicentre, observational, and retrospective study aimed to investigate the clinical characteristics and outcomes of vaccinated vs. non-vaccinated patients, both hospitalised with SARS-CoV-2 infection in 3 major hospitals in Northern Italy. Methods: Data collection was retrospective, and paper and electronic medical records of adult patients with a diagnosed SARS-CoV-2 infection were pseudo-anonymised and analysed. Vaccinated and non-vaccinated individuals were manually paired, using a predetermined matching criterion (similar age, gender, and date of hospitalisation). Demographic, clinical, treatment, and outcome data were compared between groups differing by vaccination status using Pearson's Chi-square and Mann-Whitney tests. Moreover, multiple logistic regression analyses were performed to assess the impact of vaccination status on ICU admission or intra-hospital mortality. Results: Data from 360 patients were collected. Vaccinated patients presented with a higher prevalence of relevant comorbidities, like kidney replacement therapy or haematological malignancy, despite a milder clinical presentation at the first evaluation. Non-vaccinated patients required intensive care more often than their vaccinated counterparts (8.8% vs. 1.7%, p = 0.002). Contrariwise, no difference in intra-hospital mortality was observed between the two groups (19% vs. 20%, p = 0.853). These results were confirmed by multivariable logistic regressions, which showed that vaccination was significantly associated with decreased risk of ICU admission (aOR=0.172, 95%CI: 0.039–0.542, p = 0.007), but not of intra-hospital mortality (aOR=0.996, 95%CI: 0.582–1.703, p = 0.987). Conclusions: This study provides real-world data on vaccinated patients hospitalised wit

Published
2024

11. Italian adaptation of the Uniform Data Set Neuropsychological Test Battery (I-UDSNB 1.0): development and normative data

Author

Francesca Conca, Valentina Esposito, Francesco Rundo, Davide Quaranta, Cristina Muscio, Rosa Manenti, Giulia Caruso, Ugo Lucca, Alessia Antonella Galbussera, Sonia Di Tella, Francesca Baglio, Federica L’Abbate, Elisa Canu, Valentina Catania, Massimo Filippi, Giulia Mattavelli, Barbara Poletti, Vincenzo Silani, Raffaele Lodi, Maddalena De Matteis, Michelangelo Stanzani Maserati, Andrea Arighi, Emanuela Rotondo, Antonio Tanzilli, Andrea Pace, Federica Garramone, Carlo Cavaliere, Matteo Pardini, Cristiano Rizzetto, Sandro Sorbi, Roberta Perri, Pietro Tiraboschi, Nicola Canessa, Maria Cotelli, Raffaele Ferri, Sandra Weintraub, Camillo Marra, Fabrizio Tagliavini, Eleonora Catricalà, and Stefano Francesco Cappa

Subjects
Neuropsychological tests, UDS, Alzheimer’s disease, Cognition, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Background Neuropsychological testing plays a cardinal role in the diagnosis and monitoring of Alzheimer’s disease. A major concern is represented by the heterogeneity of the neuropsychological batteries currently adopted in memory clinics and healthcare centers. The current study aimed to solve this issue. Methods Following the initiative of the University of Washington’s National Alzheimer’s Coordinating Center (NACC), we presented the Italian adaptation of the Neuropsychological Test Battery of the Uniform Data Set (I-UDSNB). We collected data from 433 healthy Italian individuals and employed regression models to evaluate the impact of demographic variables on the performance, deriving the reference norms. Results Higher education and lower age were associated with a better performance in the majority of tests, while sex affected only fluency tests and Digit Span Forward. Conclusions The I-UDSNB offers a valuable and harmonized tool for neuropsychological testing in Italy, to be used in clinical and research settings.

Published
2022
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12. Italian adaptation of the Uniform Data Set Neuropsychological Test Battery (I-UDSNB 1.0): development and normative data

Author

Conca, Francesca, Esposito, Valentina, Rundo, Francesco, Quaranta, Davide, Muscio, Cristina, Manenti, Rosa, Caruso, Giulia, Lucca, Ugo, Galbussera, Alessia Antonella, Di Tella, Sonia, Baglio, Francesca, L’Abbate, Federica, Canu, Elisa, Catania, Valentina, Filippi, Massimo, Mattavelli, Giulia, Poletti, Barbara, Silani, Vincenzo, Lodi, Raffaele, De Matteis, Maddalena, Stanzani Maserati, Michelangelo, Arighi, Andrea, Rotondo, Emanuela, Tanzilli, Antonio, Pace, Andrea, Garramone, Federica, Cavaliere, Carlo, Pardini, Matteo, Rizzetto, Cristiano, Sorbi, Sandro, Perri, Roberta, Tiraboschi, Pietro, Canessa, Nicola, Cotelli, Maria, Ferri, Raffaele, Weintraub, Sandra, Marra, Camillo, Tagliavini, Fabrizio, Catricalà, Eleonora, and Cappa, Stefano Francesco

Published
2022
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13. Correction: Italian adaptation of the Uniform Data Set Neuropsychological Test Battery (I‑UDSNB 1.0): development and normative data

Author

Francesca Conca, Valentina Esposito, Francesco Rundo, Davide Quaranta, Cristina Muscio, Rosa Manenti, Giulia Caruso, Ugo Lucca, Alessia Antonella Galbussera, Sonia Di Tella, Francesca Baglio, Federica L’Abbate, Elisa Canu, Valentina Catania, Massimo Filippi, Giulia Mattavelli, Barbara Poletti, Vincenzo Silani, Raffaele Lodi, Maddalena De Matteis, Michelangelo Stanzani Maserati, Andrea Arighi, Emanuela Rotondo, Antonio Tanzilli, Andrea Pace, Federica Garramone, Carlo Cavaliere, Matteo Pardini, Cristiano Rizzetto, Sandro Sorbi, Roberta Perri, Pietro Tiraboschi, Nicola Canessa, Maria Cotelli, Raffaele Ferri, Sandra Weintraub, Camillo Marra, Fabrizio Tagliavini, Eleonora Catricalà, and Stefano Francesco Cappa

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Published
2023
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15. Clinical characteristics and outcomes of vaccinated patients hospitalised with SARS-CoV-2 breakthrough infection: Multi-IPV, a multicentre study in Northern Italy

Author

Lombardi, Andrea, primary, Villa, Simone, additional, Colaneri, Marta, additional, Scaglione, Giovanni, additional, Bai, Francesca, additional, Varisco, Benedetta, additional, Bono, Valeria, additional, Vena, Antonio, additional, Dentone, Chiara, additional, Russo, Chiara, additional, Tettamanti, Mauro, additional, Renisi, Giulia, additional, Viero, Giulia, additional, Azzarà, Cecilia, additional, Mantero, Marco, additional, Peyvandi, Flora, additional, Bassetti, Matteo, additional, Marchetti, Giulia, additional, Muscatello, Antonio, additional, Nobili, Alessandro, additional, Gori, Andrea, additional, Bandera, Alessandra, additional, Bosari, Silvano, additional, Scudeller, Luigia, additional, Fusetti, Giuliana, additional, Rusconi, Laura, additional, Dell’Orto, Silvia, additional, Prati, Daniele, additional, Valenti, Luca, additional, Giovannelli, Silvia, additional, Manunta, Maria, additional, Lamorte, Giuseppe, additional, Ferarri, Francesca, additional, Gori., Andrea, additional, Mangioni, Davide, additional, Alagna, Laura, additional, Bozzi, Giorgio, additional, Lombardi., Andrea, additional, Ungaro, Riccardo, additional, Ancona, Giuseppe, additional, Mussa, Marco, additional, Mariani, Bianca Veronica, additional, Bolis, Matteo, additional, Iannotti, Nathalie, additional, Ludovisi, Serena, additional, Comelli, Agnese, additional, Biscarini, Simona, additional, Castelli, Valeria, additional, Palomba, Emanuele, additional, Fava, Marco, additional, Peri, Carlo Alberto, additional, Saltini, Paola, additional, Itri, Teresa, additional, Ferroni, Valentina, additional, Pastore, Valeria, additional, Massafra, Roberta, additional, Liparoti, Arianna, additional, Muheberimana, Toussaint, additional, Giommi, Alessandro, additional, Bianco, Rosaria, additional, Chitani, Grazia Eliana, additional, Bobbio, Chiara, additional, De Matteis, Irene, additional, Bonomi, Angelo Bianchi, additional, Gualtierotti, Roberta, additional, Ferrari, Barbara, additional, Rossio, Raffaella, additional, Boasi, Nadia, additional, Pagliaro, Erica, additional, Massimo, Costanza, additional, De Caro, Michele, additional, Giachi, Andrea, additional, Montano, Nicola, additional, Vigone, Barbara, additional, Bellocchi, Chiara, additional, Carandina, Angelica, additional, Fiorelli, Elisa, additional, Melli, Valerie, additional, Tobaldini, Eleonora, additional, Blasi, Francesco, additional, Aliberti, Stefano, additional, Spotti, Maura, additional, Terranova, Leonardo, additional, Misuraca, Sofia, additional, D’Adda, Alice, additional, Della Fiore, Silvia, additional, Di Pasquale, Marta, additional, Mantero., Marco, additional, Contarini, Martina, additional, Ori, Margherita, additional, Morlacchi, Letizia, additional, Rossetti, Valeria, additional, Gramegna, Andrea, additional, Pappalettera, Maria, additional, Cavallini, Mirta, additional, Buscemi, Agata, additional, Vicenzi, Marco, additional, Rota, Irena, additional, Costantino, Giorgio, additional, Solbiati, Monica, additional, Furlan, Ludovico, additional, Mancarella, Marta, additional, Colombo, Giulia, additional, Colombo, Giorgio, additional, Fanin, Alice, additional, Passarella, Mariele, additional, Monzani, Valter, additional, Canetta, Ciro, additional, Rovellini, Angelo, additional, Barbetta, Laura, additional, Billi, Filippo, additional, Folli, Christian, additional, Accordino, Silvia, additional, Maira, Diletta, additional, Hu, Cinzia Maria, additional, Motta, Irene, additional, Scaramellini, Natalia, additional, Fracanzani, Anna Ludovica, additional, Lombardi, Rosa, additional, Cespiati, Annalisa, additional, Cesari, Matteo, additional, Lucchi, Tiziano, additional, Proietti, Marco, additional, Calcaterra, Laura, additional, Mandelli, Clara, additional, Coppola, Carlotta, additional, Cerizza, Arturo, additional, Pesenti, Antonio Maria, additional, Grasselli, Giacomo, additional, Galazzi, Alessandro, additional, Nobili., Alessandro, additional, Monti, Igor, additional, Galbussera, Alessia Antonella, additional, Crisafulli, Ernesto, additional, Girelli, Domenico, additional, Maroccia, Alessio, additional, Gabbiani, Daniele, additional, Busti, Fabiana, additional, Vianello, Alice, additional, Biondan, Marta, additional, Sartori, Filippo, additional, Faverio, Paola, additional, Pesci, Alberto, additional, Zucchetti, Stefano, additional, Bonfanti, Paolo, additional, Rossi, Marianna, additional, Beretta, Ilaria, additional, Spolti, Anna, additional, Harari, Sergio, additional, Elia, Davide, additional, Cassandro, Roberto, additional, Caminati, Antonella, additional, Cipollone, Francesco, additional, Guagnano, Maria Teresa, additional, D’Ardes, Damiano, additional, Rossi, Ilaria, additional, Vezzani, Francesca, additional, Spanevello, Antonio, additional, Cherubino, Francesca, additional, Visca, Dina, additional, Contoli, Marco, additional, Papi, Alberto, additional, Morandi, Luca, additional, Battistini, Nicholas, additional, Moreo, Guido Luigi, additional, Iannuzzi, Pasqualina, additional, Fumagalla, Daniele, additional, and Leone, Sara, additional

Published
2024
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16. Mortality during the SARS-CoV-2 Pandemic: A Comparative Analysis between Lombardy in Italy and Israel.

Author

Najjar-Debbiny, Ronza, Nobili, Alessandro, Mannuccio Mannucci, Pier, Barnett-Griness, Ofra, Saliba, Walid, Adir, Yochai, Antonella Galbussera, Alessia, Tettamanti, Mauro, D'Avanzo, Barbara, and Harari, Sergio

Subjects
COVID-19 pandemic, COVID-19, COVID-19 vaccines, VACCINATION status, INTENSIVE care units
Abstract

Background: This retrospective study contrasts the impact of the SARS-CoV-2 pandemic in Lombardy (Italy) and Israel, focusing on mortality, healthcare response, public health measures, and demographics. Methods: We analyzed SARS-CoV-2 data from Lombardy and Israel covering four viral waves. Data included infection rates, hospitalizations, and mortality. In Lombardy, healthcare data were collected from the administrative database of the Lombardy Welfare Directorate; in Israel, they were collected from Clalit Health Services and the Israeli Ministry of Health's COVID-19 database. Statistical analyses compared trends in infection rates, demographics, and mortality rates across the four viral waves by using logistic and linear regression models and adjusting for age, sex, and comorbidities. Results: Lombardy exhibited significantly higher SARS-CoV-2 infections and COVID-19 hospitalization rates during the first wave than Israel, with 71,558 cases over a population sample of ~10 million versus 5741 over a population sample of ~4.7 million in Israel. The majority of cases in Israel were managed at home, with 18 cases only (0.3%) requiring intensive care unit (ICU) hospitalization during the first wave, compared to 4104 (5.7%) cases in Lombardy. Israel's vaccination campaign began earlier, so that by the fourth wave, 439,545 (42.2%) people in Israel were fully vaccinated with three doses, compared to 214,542 (22.9%) in Lombardy. Mortality decreased over time in both sites, dropping from 103 cases (1.8%) to 1550 (0.1%) in Israel and from 13,372 (18.7%) to 4388 (0.3%) in Lombardy. Conclusions: Early public health interventions and vaccination were crucial in managing the SARS-CoV-2 impact. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Failure to reduce benzodiazepine prescriptions through the implementation of a psychological intervention for insomnia in an Italian mental health service.

Author

D'Avanzo, Barbara, Parabiaghi, Alberto, Galbussera, Alessia A., Tettamanti, Mauro, Monti, Igor, Di Gregorio, Luana, Zambello, Francesco, Goglio, Marco Maria, Recla, Elisabetta, Di Napoli, Wilma Angela, and Barbato, Angelo

Subjects
BENZODIAZEPINES, PSYCHOTHERAPY, MENTAL health services, MEDICAL prescriptions, PSYCHIATRIC treatment, OUTPATIENT services in hospitals, RESEARCH funding, INSOMNIA, EDUCATIONAL outcomes, MEDICAL care, TRANQUILIZING drugs, DEPRESCRIBING, DESCRIPTIVE statistics, PRE-tests & post-tests, ODDS ratio, PHYSICIAN practice patterns, DRUG prescribing, CONFIDENCE intervals, SLEEP hygiene
Abstract

Purpose: Despite the evidence of higher effectiveness of psychological interventions for insomnia compared to pharmacological ones, drug prescriptions for insomnia remain frequent. This study has assessed patterns of prescriptions of BZDs for insomnia before and after the delivery of a training in psychological interventions to professionals working in the services of a Department of Mental Health in northern Italy. Methods: The intervention consisted in two training sessions about psychological interventions for insomnia delivered to professionals of the participating services. The prevalence of users with a prescription of BZDs for insomnia in an index period after the delivery of the training was compared to the prevalence in an index period before the training. Results: Among 727 people assessed for BZDs prescription at pre-intervention, 306 (42.1%, 95% CI 0.39–0.46) had a prescription, and 344 (49.2%, 95% CI 0.45–0.53) had a prescription among 699 people assessed at post-intervention, corresponding to a significant odds ratio of 1.33 to be prescribed with BZDs in the second index period compared to the first one. Psychological interventions were offered to a small group of patients. Conclusion: Prescribing attitudes of BZDs for insomnia were not modified after the training and delivery of a psychological intervention in a mental healthcare outpatient setting. Prescribing habits should be addressed more directly in training, and professionals should be more aware of risks of BZDs assumption. The failure in changing drug prescriptions in this study should prompt more real-world studies of the application of evidence-based strategies, particularly in outpatient mental health settings. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Patient-Reported Symptoms and Sequelae 12 Months After COVID-19 in Hospitalized Adults: A Multicenter Long-Term Follow-Up Study

Author

Agnese Comelli, Giulia Viero, Greta Bettini, Alessandro Nobili, Mauro Tettamanti, Alessia Antonella Galbussera, Antonio Muscatello, Marco Mantero, Ciro Canetta, Filippo Martinelli Boneschi, Andrea Arighi, Paolo Brambilla, Maurizio Vecchi, Pietro Lampertico, Paolo Bonfanti, Marco Contoli, Francesco Blasi, Andrea Gori, and Alessandra Bandera

Subjects
long COVID-19, SARS-CoV-2, long-term sequelae, COVID-19, dyspnea, Medicine (General), R5-920
Abstract

ObjectiveOur knowledge on the long-term consequences of COVID-19 is still scarce despite the clinical relevance of persisting syndrome. The aim of this study was to analyze patient-reported outcomes, including assessment by specific questionnaires of health impairment and symptoms.MethodsThis is a prospective, observational and multicenter cohort study coordinated by Fondazione IRCSS Ca' Granda Ospedale Maggiore Policlinico di Milano and Istituto di Ricerche Farmacologiche Mario Negri IRCCS including eight hospitals located in North and Central Italy. A telephone interview to assess rehospitalization, access to health care resources, general health status subjective evaluation, and symptoms was performed at 12 months after the discharge in patients admitted to hospital because of COVID-19 from February 2020 to the end of May 2020.ResultsAmong the 776 patients discharged alive, 44 (5.7%) died, 456 subjects (58.8%) completed the questionnaire and 276 (35.6%) were not reachable or refused to join the telephone interview. The mean age of the study population was 59.4 years (SD 14.1), 69.8% of individuals needed oxygen support during hospitalization and 10.4% were admitted to ICU. Overall, 91.7% of participants reported at least one symptom/sequela at 12 months. Exertional dyspnea (71.7%), fatigue (54.6%), and gastrointestinal symptoms (32.8%) were the most reported ones. Health issues after discharge including hospitalization or access to emergency room were described by 19.4% of subjects. Female and presence of comorbidities were independent predictors of whealth impairment and presence of ≥2 symptoms/sequelae after 12 months from hospitalization for COVID-19.ConclusionsPatient-reported symptoms and sequelae, principally dyspnea and fatigue, are found in most individuals even 12 months from COVID-19 hospitalization. Long-term follow-up based on patient-centered outcome can contribute to plan tailored interventions.

Published
2022
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19. Willingness to share contacts in case of COVID-19 positivity–predictors of collaboration resistance in a nation-wide Italian survey

Author

Boris Bikbov, Mauro Tettamanti, Alexander Bikbov, Barbara D’Avanzo, Alessia Antonella Galbussera, Alessandro Nobili, Gemma Calamandrei, Valentina Candini, Fabrizio Starace, Cristina Zarbo, and Giovanni de Girolamo

Subjects
Medicine, Science
Abstract

Background The unwillingness to share contacts is one of the least explored aspects of the COVID-19 pandemic. Here we report the factors associated with resistance to collaborate on contact tracing, based on the results of a nation-wide survey conducted in Italy in January-March 2021. Methods and findings The repeated cross-sectional on-line survey was conducted among 7,513 respondents (mean age 45.7, 50.4% women) selected to represent the Italian adult population 18–70 years old. Two groups were defined based on the direct question response expressing (1) unwillingness or (2) willingness to share the names of individuals with whom respondents had contact. We selected 70% of participants (training data set) to produce several multivariable binomial generalized linear models and estimated the proportion of variation explained by the model by McFadden R2, and the model’s discriminatory ability by the index of concordance. Then, we have validated the regression models using the remaining 30% of respondents (testing data set), and identified the best performing model by removing the variables based on their impact on the Akaike information criterion and then evaluating the model predictive accuracy. We also performed a sensitivity analysis using principal component analysis. Overall, 5.5% of the respondents indicated that in case of positive SARS-CoV-2 test they would not share contacts. Of note, this percentage varied from 0.8% to 46.5% depending on the answers to other survey questions. From the 139 questions included in the multivariable analysis, the initial model proposed 20 independent factors that were reduced to the 6 factors with only modest changes in the model performance. The 6-variables model demonstrated good performance in the training (c-index 0.85 and McFadden R2 criteria 0.25) and in the testing data set (93.3% accuracy, AUC 0.78, sensitivity 30.4% and specificity 97.4%). The most influential factors related to unwillingness to share contacts were the lack of intention to perform the test in case of contact with a COVID-19 positive individual (OR 5.60, 95% CI 4.14 to 7.58, in a fully adjusted multivariable analysis), disagreement that the government should be allowed to force people into self-isolation (OR 1.79, 95% CI 1.12 to 2.84), disagreement with the national vaccination schedule (OR 2.63, 95% CI 1.86 to 3.69), not following to the preventive anti-COVID measures (OR 3.23, 95% CI 1.85 to 5.59), the absence of people in the immediate social environment who have been infected with COVID-19 (1.66, 95% CI 1.24 to 2.21), as well as difficulties in finding or understanding the information about the infection or related recommendations. A limitation of this study is the under-representation of persons not participating in internet-based surveys and some vulnerable groups like homeless people, persons with disabilities or migrants. Conclusions Our analysis revealed several groups that expressed unwillingness to collaborate on contact tracing. The identified patterns may play a principal role not only in the COVID-19 epidemic but also be important for possible future public health threats, and appropriate interventions for their correction should be developed and ready for the implementation.

Published
2022

20. Antihypertensive treatment changes and related clinical outcomes in older hospitalized patients

Author

Cicco, S, D'Abbondanza, M, Proietti, M, Zaccone, V, Pes, C, Caradio, F, Mattioli, M, Piano, S, Marra, A, Nobili, A, Mannucci, P, Pietrangelo, A, Sesti, G, Buzzetti, E, Salzano, A, Cimellaro, A, Perticone, F, Violi, F, Corazza, G, Corrao, S, Marengoni, A, Salerno, F, Cesari, M, Tettamanti, M, Pasina, L, Franchi, C, Novella, A, Miglio, G, Galbussera, A, Ardoino, I, Prisco, D, Silvestri, E, Emmi, G, Bettiol, A, Mattioli, I, Biolo, G, Zanetti, M, Bartelloni, G, Zaccari, M, Chiuch, M, Vanoli, M, Grignani, G, Pulixi, E, Pirro, M, Lupattelli, G, Bianconi, V, Alcidi, R, Giotta, A, Mannarino, M, Girelli, D, Busti, F, Marchi, G, Barbagallo, M, Dominguez, L, Beneduce, V, Cacioppo, F, Natoli, G, Mularo, S, Raspanti, M, Argano, C, Cavallaro, F, Zoli, M, Matacena, M, Orio, G, Magnolfi, E, Serafini, G, Simili, A, Brunori, M, Lazzari, I, Cappellini, M, Fabio, G, De Amicis, M, De Luca, G, Scaramellini, N, Di Stefano, V, Leoni, S, Seghezzi, S, Di Mauro, A, Maira, D, Mancarella, M, Lucchi, T, Rossi, P, Clerici, M, Bonini, G, Conti, F, Prolo, S, Fabrizi, M, Martelengo, M, Vigani, G, Di Sabatino, A, Miceli, E, Lenti, M, Pisati, M, Pitotti, L, Padula, D, Antoci, V, Cambie, G, Pontremoli, R, Beccati, V, Nobili, G, Leoncini, G, Alberto, J, Cattaneo, F, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Guagnano, M, Rossi, I, Valeriani, E, D'Ardes, D, Esposito, L, Sestili, S, Angelucci, E, Mancuso, G, Calipari, D, Bartone, M, Delitala, G, Berria, M, Delitala, A, Muscaritoli, M, Molfino, A, Petrillo, E, Giorgi, A, Gracin, C, Imbimbo, G, Zuccala, G, D'Aurizio, G, Romanelli, G, Volpini, A, Lucente, D, Manzoni, F, Pirozzi, A, Zucchelli, A, Picardi, A, Gentilucci, U, Gallo, P, Dell'Unto, C, Bellelli, G, Corsi, M, Antonucci, C, Sidoli, C, Principato, G, Bonfanti, A, Szabo, H, Mazzola, P, Piazzoli, A, Arturi, F, Succurro, E, Tassone, B, Giofre, F, Serra, M, Bleve, M, Brucato, A, De Falco, T, Negro, E, Brenna, M, Trotta, L, Squintani, G, Randi, M, Fabris, F, Bertozzi, I, Bogoni, G, Rabuini, M, Prandini, T, Ratti, F, Zurlo, C, Cerruti, L, Cosi, E, Manfredini, R, Fabbian, F, Boari, B, De Giorgi, A, Tiseo, R, Paolisso, G, Rizzo, M, Catalano, C, Di Meo, I, Borghi, C, Strocchi, E, Ianniello, E, Soldati, M, Schiavone, S, Bragagni, A, Leoni, F, De Sando, V, Scarduelli, S, Cammarosano, M, Pareo, I, Sabba, C, Vella, F, Suppressa, P, De Vincenzo, G, Comitangelo, A, Amoruso, E, Custodero, C, Re, G, Schilardi, A, Loparco, F, Fenoglio, L, Falcetta, A, Giraudo, A, D'Aniano, S, Fracanzani, A, Tiraboschi, S, Cespiati, A, Oberti, G, Sigon, G, Cinque, F, Peyvandi, F, Rossio, R, Colombo, G, Agosti, P, Pagliaro, E, Semproni, E, Ciro, C, Monzani, V, Savojardo, V, Ceriani, G, Folli, C, Pallini, G, Montecucco, F, Ottonello, L, Caserza, L, Vischi, G, Kassem, S, Liberale, L, Liberato, N, Tognin, T, Purrello, F, Di Pino, A, Piro, S, Rozzini, R, Falanga, L, Pisciotta, M, Bellucci, F, Buffelli, S, Ferrandina, C, Mazzeo, F, Spazzini, E, Cono, G, Cesaroni, G, Montrucchio, G, Peasso, P, Favale, E, Poletto, C, Margaria, C, Sanino, M, Perri, L, Guasti, L, Rotunno, F, Castiglioni, L, Maresca, A, Squizzato, A, Campiotti, L, Grossi, A, Diprizio, R, Dentali, F, Bertolotti, M, Mussi, C, Lancellotti, G, Libbra, M, Galassi, M, Grassi, Y, Greco, A, Bigi, E, Pellegrini, E, Orlandi, L, Dondi, G, Carulli, L, Sciacqua, A, Perticone, M, Battaglia, R, Maio, R, Scozzafava, A, Condoleo, V, Falbo, T, Colangelo, L, Filice, M, Clausi, E, Stanghellini, V, Ruggeri, E, del Vecchio, S, Benzoni, I, Salvi, A, Leonardi, R, Damiani, G, Moroncini, G, Capeci, W, Martino, G, Biondi, L, Pettinari, P, Ormas, M, Filippini, E, Benfaremo, D, Romiti, R, Ghio, R, Col, A, Minisola, S, Cilli, M, Labbadia, G, Afeltra, A, Marigliano, B, Pipita, M, Castellino, P, Zanoli, L, Gennaro, A, Gaudio, A, Pignataro, S, Mete, F, Gino, M, Moreo, G, Pina, G, Ballestrero, A, Ferrando, F, Gonella, R, Cerminara, D, Setti, P, Traversa, C, Scarsi, C, Graziella, B, Baldassarre, S, Fragapani, S, Gruden, G, Berti, F, Famularo, G, Tarsitani, P, Castello, R, Pasino, M, Maggio, M, Ceda, G, Morganti, S, Artoni, A, Grossi, M, Del Giacco, S, Firinu, D, Costanzo, G, Argiolas, G, Paoletti, G, Losa, F, Montalto, G, Licata, A, Montalto, F, Corica, F, Basile, G, Catalano, A, Bellone, F, Principato, C, Malatino, L, Stancanelli, B, Terranova, V, Di Marca, S, Di Quattro, R, La Malfa, L, Caruso, R, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Ticinesi, A, Nouvenne, A, Minuz, P, Fondrieschi, L, Imperiale, G, Morellini, S, Pirisi, M, Fra, G, Sola, D, Bellan, M, Quadri, R, Larovere, E, Novelli, M, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Napoli, F, Aiello, I, Salvatore, T, Monaco, L, Ricozzi, C, Pilotto, A, Indiano, I, Gandolfo, F, Pasini, F, Capecchi, P, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Bernardi, M, Bassi, S, Santi, L, Zaccherini, G, Durante, V, Tirotta, D, Eusebi, G, Cattaneo, M, Amoruso, M, Fracasso, P, Fasolino, C, Tresoldi, M, Bozzolo, E, Damanti, S, Porta, M, Armentaro, G, Arnone, M, Barone, M, Bertolino, L, Bianco, S, Binello, N, Brancati, S, Buonauro, A, Cordeddu, W, Curcio, R, Dalbeni, A, D'Agnano, S, De Feo, M, Donnarumma, E, Fei, M, Gambino, C, Giorgini, P, Lombardi, R, Miceli, G, Naccarato, P, Noviello, S, Olivieri, G, Parente, R, Pignataro, F, Poma, S, Porceddu, E, Pucci, G, Ricchio, M, Sabena, A, Salice, M, Santarossa, C, Savona, A, Savrie, C, Scicali, R, Stabile, M, Talerico, G, Talia, M, Tassone, E, Teatini, T, Tombolini, E, Traversa, M, Vettore, E, Vignal, A, Vilardi, L, Villani, R, Vitale, F, Cicco S., D'Abbondanza M., Proietti M., Zaccone V., Pes C., Caradio F., Mattioli M., Piano S., Marra A. M., Nobili A., Mannucci P. M., Pietrangelo A., Sesti G., Buzzetti E., Salzano A., Cimellaro A., Perticone F., Violi F., Corazza G. R., Corrao S., Marengoni A., Salerno F., Cesari M., Tettamanti M., Pasina L., Franchi C., Novella A., Miglio G., Galbussera A. A., Ardoino I., Prisco D., Silvestri E., Emmi G., Bettiol A., Mattioli I., Biolo G., Zanetti M., Bartelloni G., Zaccari M., Chiuch M., Vanoli M., Grignani G., Pulixi E. A., Pirro M., Lupattelli G., Bianconi V., Alcidi R., Giotta A., Mannarino M. R., Girelli D., Busti F., Marchi G., Barbagallo M., Dominguez L., Beneduce V., Cacioppo F., Natoli G., Mularo S., Raspanti M., Argano C., Cavallaro F., Zoli M., Matacena M. L., Orio G., Magnolfi E., Serafini G., Simili A., Brunori M., Lazzari I., Cappellini M. D., Fabio G., De Amicis M. M., De Luca G., Scaramellini N., Di Stefano V., Leoni S., Seghezzi S., Di Mauro A. D., Maira D., Mancarella M., Lucchi T., Rossi P. D., Clerici M., Bonini G., Conti F., Prolo S., Fabrizi M., Martelengo M., Vigani G., Di Sabatino A., Miceli E., Lenti M. V., Pisati M., Pitotti L., Padula D., Antoci V., Cambie G., Pontremoli R., Beccati V., Nobili G., Leoncini G., Alberto J., Cattaneo F., Anastasio L., Sofia L., Carbone M., Cipollone F., Guagnano M. T., Rossi I., Valeriani E., D'Ardes D., Esposito L., Sestili S., Angelucci E., Mancuso G., Calipari D., Bartone M., Delitala G., Berria M., Delitala A., Muscaritoli M., Molfino A., Petrillo E., Giorgi A., Gracin C., Imbimbo G., Zuccala G., D'Aurizio G., Romanelli G., Volpini A., Lucente D., Manzoni F., Pirozzi A., Zucchelli A., Picardi A., Gentilucci U. V., Gallo P., Dell'Unto C., Bellelli G., Corsi M., Antonucci C., Sidoli C., Principato G., Bonfanti A., Szabo H., Mazzola P., Piazzoli A., Arturi F., Succurro E., Tassone B., Giofre F., Serra M. G., Bleve M. A., Brucato A., De Falco T., Negro E., Brenna M., Trotta L., Squintani G. L., Randi M. L., Fabris F., Bertozzi I., Bogoni G., Rabuini M. V., Prandini T., Ratti F., Zurlo C., Cerruti L., Cosi E., Manfredini R., Fabbian F., Boari B., De Giorgi A., Tiseo R., Paolisso G., Rizzo M. R., Catalano C., Di Meo I., Borghi C., Strocchi E., Ianniello E., Soldati M., Schiavone S., Bragagni A., Leoni F. G., De Sando V., Scarduelli S., Cammarosano M., Pareo I., Sabba C., Vella F. S., Suppressa P., De Vincenzo G. M., Comitangelo A., Amoruso E., Custodero C., Re G., Schilardi A., Loparco F., Fenoglio L., Falcetta A., Giraudo A. V., D'Aniano S., Fracanzani A. L., Tiraboschi S., Cespiati A., Oberti G., Sigon G., Cinque F., Peyvandi F., Rossio R., Colombo G., Agosti P., Pagliaro E., Semproni E., Ciro C., Monzani V., Savojardo V., Ceriani G., Folli C., Pallini G., Montecucco F., Ottonello L., Caserza L., Vischi G., Kassem S., Liberale L., Liberato N. L., Tognin T., Purrello F., Di Pino A., Piro S., Rozzini R., Falanga L., Pisciotta M. S., Bellucci F. B., Buffelli S., Ferrandina C., Mazzeo F., Spazzini E., Cono G., Cesaroni G., Montrucchio G., Peasso P., Favale E., Poletto C., Margaria C., Sanino M., Perri L., Guasti L., Rotunno F., Castiglioni L., Maresca A., Squizzato A., Campiotti L., Grossi A., Diprizio R. D., Dentali F., Bertolotti M., Mussi C., Lancellotti G., Libbra M. V., Galassi M., Grassi Y., Greco A., Bigi E., Pellegrini E., Orlandi L., Dondi G., Carulli L., Sciacqua A., Perticone M., Battaglia R., Maio R., Scozzafava A., Condoleo V., Falbo T., Colangelo L., Filice M., Clausi E., Stanghellini V., Ruggeri E., del Vecchio S., Benzoni I., Salvi A., Leonardi R., Damiani G., Moroncini G., Capeci W., Martino G. P., Biondi L., Pettinari P., Ormas M., Filippini E., Benfaremo D., Romiti R., Ghio R., Col A. D., Minisola S., Cilli M., Labbadia G., Afeltra A., Marigliano B., Pipita M. E., Castellino P., Zanoli L., Gennaro A., Gaudio A., Pignataro S., Mete F., Gino M., Moreo G., Pina G., Ballestrero A., Ferrando F., Gonella R., Cerminara D., Setti P., Traversa C., Scarsi C., Graziella B., Baldassarre S., Fragapani S., Gruden G., Berti F., Famularo G., Tarsitani P., Castello R., Pasino M., Maggio M. G., Ceda G. P., Morganti S., Artoni A., Grossi M., Del Giacco S., Firinu D., Costanzo G., Argiolas G., Paoletti G., Losa F., Montalto G., Licata A., Montalto F. A., Corica F., Basile G., Catalano A., Bellone F., Principato C., Malatino L., Stancanelli B., Terranova V., Di Marca S., Di Quattro R., La Malfa L., Caruso R., Mecocci P., Ruggiero C., Boccardi V., Meschi T., Ticinesi A., Nouvenne A., Minuz P., Fondrieschi L., Imperiale G. N., Morellini S., Pirisi M., Fra G. P., Sola D., Bellan M., Quadri R., Larovere E., Novelli M., Simeone E., Scurti R., Tolloso F., Tarquini R., Valoriani A., Dolenti S., Vannini G., Volpi R., Bocchi P., Vignali A., Harari S., Lonati C., Napoli F., Aiello I., Salvatore T., Monaco L., Ricozzi C., Pilotto A., Indiano I., Gandolfo F., Pasini F. L., Capecchi P. L., Nuti R., Valenti R., Ruvio M., Cappelli S., Palazzuoli A., Bernardi M., Bassi S. L., Santi L., Zaccherini G., Durante V., Tirotta D., Eusebi G., Cattaneo M., Amoruso M. V., Fracasso P., Fasolino C., Tresoldi M., Bozzolo E., Damanti S., Porta M., Armentaro G., Arnone M. I., Barone M., Bertolino L., Bianco S., Binello N., Brancati S., Buonauro A., Cordeddu W., Curcio R., Dalbeni A., D'Agnano S., De Feo M., Donnarumma E., Fei M., Gambino C. G., Giorgini P., Lombardi R., Miceli G., Naccarato P., Noviello S., Olivieri G., Parente R., Pignataro F. S., Poma S., Porceddu E., Pucci G., Ricchio M., Sabena A., Salice M., Santarossa C., Savona A., Savrie C., Scicali R., Stabile M., Talerico G., Talia M., Tassone E. J., Teatini T., Tombolini E., Traversa M., Vettore E., Vignal A., Vilardi L., Villani R., Vitale F., Cicco, S, D'Abbondanza, M, Proietti, M, Zaccone, V, Pes, C, Caradio, F, Mattioli, M, Piano, S, Marra, A, Nobili, A, Mannucci, P, Pietrangelo, A, Sesti, G, Buzzetti, E, Salzano, A, Cimellaro, A, Perticone, F, Violi, F, Corazza, G, Corrao, S, Marengoni, A, Salerno, F, Cesari, M, Tettamanti, M, Pasina, L, Franchi, C, Novella, A, Miglio, G, Galbussera, A, Ardoino, I, Prisco, D, Silvestri, E, Emmi, G, Bettiol, A, Mattioli, I, Biolo, G, Zanetti, M, Bartelloni, G, Zaccari, M, Chiuch, M, Vanoli, M, Grignani, G, Pulixi, E, Pirro, M, Lupattelli, G, Bianconi, V, Alcidi, R, Giotta, A, Mannarino, M, Girelli, D, Busti, F, Marchi, G, Barbagallo, M, Dominguez, L, Beneduce, V, Cacioppo, F, Natoli, G, Mularo, S, Raspanti, M, Argano, C, Cavallaro, F, Zoli, M, Matacena, M, Orio, G, Magnolfi, E, Serafini, G, Simili, A, Brunori, M, Lazzari, I, Cappellini, M, Fabio, G, De Amicis, M, De Luca, G, Scaramellini, N, Di Stefano, V, Leoni, S, Seghezzi, S, Di Mauro, A, Maira, D, Mancarella, M, Lucchi, T, Rossi, P, Clerici, M, Bonini, G, Conti, F, Prolo, S, Fabrizi, M, Martelengo, M, Vigani, G, Di Sabatino, A, Miceli, E, Lenti, M, Pisati, M, Pitotti, L, Padula, D, Antoci, V, Cambie, G, Pontremoli, R, Beccati, V, Nobili, G, Leoncini, G, Alberto, J, Cattaneo, F, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Guagnano, M, Rossi, I, Valeriani, E, D'Ardes, D, Esposito, L, Sestili, S, Angelucci, E, Mancuso, G, Calipari, D, Bartone, M, Delitala, G, Berria, M, Delitala, A, Muscaritoli, M, Molfino, A, Petrillo, E, Giorgi, A, Gracin, C, Imbimbo, G, Zuccala, G, D'Aurizio, G, Romanelli, G, Volpini, A, Lucente, D, Manzoni, F, Pirozzi, A, Zucchelli, A, Picardi, A, Gentilucci, U, Gallo, P, Dell'Unto, C, Bellelli, G, Corsi, M, Antonucci, C, Sidoli, C, Principato, G, Bonfanti, A, Szabo, H, Mazzola, P, Piazzoli, A, Arturi, F, Succurro, E, Tassone, B, Giofre, F, Serra, M, Bleve, M, Brucato, A, De Falco, T, Negro, E, Brenna, M, Trotta, L, Squintani, G, Randi, M, Fabris, F, Bertozzi, I, Bogoni, G, Rabuini, M, Prandini, T, Ratti, F, Zurlo, C, Cerruti, L, Cosi, E, Manfredini, R, Fabbian, F, Boari, B, De Giorgi, A, Tiseo, R, Paolisso, G, Rizzo, M, Catalano, C, Di Meo, I, Borghi, C, Strocchi, E, Ianniello, E, Soldati, M, Schiavone, S, Bragagni, A, Leoni, F, De Sando, V, Scarduelli, S, Cammarosano, M, Pareo, I, Sabba, C, Vella, F, Suppressa, P, De Vincenzo, G, Comitangelo, A, Amoruso, E, Custodero, C, Re, G, Schilardi, A, Loparco, F, Fenoglio, L, Falcetta, A, Giraudo, A, D'Aniano, S, Fracanzani, A, Tiraboschi, S, Cespiati, A, Oberti, G, Sigon, G, Cinque, F, Peyvandi, F, Rossio, R, Colombo, G, Agosti, P, Pagliaro, E, Semproni, E, Ciro, C, Monzani, V, Savojardo, V, Ceriani, G, Folli, C, Pallini, G, Montecucco, F, Ottonello, L, Caserza, L, Vischi, G, Kassem, S, Liberale, L, Liberato, N, Tognin, T, Purrello, F, Di Pino, A, Piro, S, Rozzini, R, Falanga, L, Pisciotta, M, Bellucci, F, Buffelli, S, Ferrandina, C, Mazzeo, F, Spazzini, E, Cono, G, Cesaroni, G, Montrucchio, G, Peasso, P, Favale, E, Poletto, C, Margaria, C, Sanino, M, Perri, L, Guasti, L, Rotunno, F, Castiglioni, L, Maresca, A, Squizzato, A, Campiotti, L, Grossi, A, Diprizio, R, Dentali, F, Bertolotti, M, Mussi, C, Lancellotti, G, Libbra, M, Galassi, M, Grassi, Y, Greco, A, Bigi, E, Pellegrini, E, Orlandi, L, Dondi, G, Carulli, L, Sciacqua, A, Perticone, M, Battaglia, R, Maio, R, Scozzafava, A, Condoleo, V, Falbo, T, Colangelo, L, Filice, M, Clausi, E, Stanghellini, V, Ruggeri, E, del Vecchio, S, Benzoni, I, Salvi, A, Leonardi, R, Damiani, G, Moroncini, G, Capeci, W, Martino, G, Biondi, L, Pettinari, P, Ormas, M, Filippini, E, Benfaremo, D, Romiti, R, Ghio, R, Col, A, Minisola, S, Cilli, M, Labbadia, G, Afeltra, A, Marigliano, B, Pipita, M, Castellino, P, Zanoli, L, Gennaro, A, Gaudio, A, Pignataro, S, Mete, F, Gino, M, Moreo, G, Pina, G, Ballestrero, A, Ferrando, F, Gonella, R, Cerminara, D, Setti, P, Traversa, C, Scarsi, C, Graziella, B, Baldassarre, S, Fragapani, S, Gruden, G, Berti, F, Famularo, G, Tarsitani, P, Castello, R, Pasino, M, Maggio, M, Ceda, G, Morganti, S, Artoni, A, Grossi, M, Del Giacco, S, Firinu, D, Costanzo, G, Argiolas, G, Paoletti, G, Losa, F, Montalto, G, Licata, A, Montalto, F, Corica, F, Basile, G, Catalano, A, Bellone, F, Principato, C, Malatino, L, Stancanelli, B, Terranova, V, Di Marca, S, Di Quattro, R, La Malfa, L, Caruso, R, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Ticinesi, A, Nouvenne, A, Minuz, P, Fondrieschi, L, Imperiale, G, Morellini, S, Pirisi, M, Fra, G, Sola, D, Bellan, M, Quadri, R, Larovere, E, Novelli, M, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Napoli, F, Aiello, I, Salvatore, T, Monaco, L, Ricozzi, C, Pilotto, A, Indiano, I, Gandolfo, F, Pasini, F, Capecchi, P, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Bernardi, M, Bassi, S, Santi, L, Zaccherini, G, Durante, V, Tirotta, D, Eusebi, G, Cattaneo, M, Amoruso, M, Fracasso, P, Fasolino, C, Tresoldi, M, Bozzolo, E, Damanti, S, Porta, M, Armentaro, G, Arnone, M, Barone, M, Bertolino, L, Bianco, S, Binello, N, Brancati, S, Buonauro, A, Cordeddu, W, Curcio, R, Dalbeni, A, D'Agnano, S, De Feo, M, Donnarumma, E, Fei, M, Gambino, C, Giorgini, P, Lombardi, R, Miceli, G, Naccarato, P, Noviello, S, Olivieri, G, Parente, R, Pignataro, F, Poma, S, Porceddu, E, Pucci, G, Ricchio, M, Sabena, A, Salice, M, Santarossa, C, Savona, A, Savrie, C, Scicali, R, Stabile, M, Talerico, G, Talia, M, Tassone, E, Teatini, T, Tombolini, E, Traversa, M, Vettore, E, Vignal, A, Vilardi, L, Villani, R, Vitale, F, Cicco S., D'Abbondanza M., Proietti M., Zaccone V., Pes C., Caradio F., Mattioli M., Piano S., Marra A. M., Nobili A., Mannucci P. M., Pietrangelo A., Sesti G., Buzzetti E., Salzano A., Cimellaro A., Perticone F., Violi F., Corazza G. R., Corrao S., Marengoni A., Salerno F., Cesari M., Tettamanti M., Pasina L., Franchi C., Novella A., Miglio G., Galbussera A. A., Ardoino I., Prisco D., Silvestri E., Emmi G., Bettiol A., Mattioli I., Biolo G., Zanetti M., Bartelloni G., Zaccari M., Chiuch M., Vanoli M., Grignani G., Pulixi E. A., Pirro M., Lupattelli G., Bianconi V., Alcidi R., Giotta A., Mannarino M. R., Girelli D., Busti F., Marchi G., Barbagallo M., Dominguez L., Beneduce V., Cacioppo F., Natoli G., Mularo S., Raspanti M., Argano C., Cavallaro F., Zoli M., Matacena M. L., Orio G., Magnolfi E., Serafini G., Simili A., Brunori M., Lazzari I., Cappellini M. D., Fabio G., De Amicis M. M., De Luca G., Scaramellini N., Di Stefano V., Leoni S., Seghezzi S., Di Mauro A. D., Maira D., Mancarella M., Lucchi T., Rossi P. D., Clerici M., Bonini G., Conti F., Prolo S., Fabrizi M., Martelengo M., Vigani G., Di Sabatino A., Miceli E., Lenti M. V., Pisati M., Pitotti L., Padula D., Antoci V., Cambie G., Pontremoli R., Beccati V., Nobili G., Leoncini G., Alberto J., Cattaneo F., Anastasio L., Sofia L., Carbone M., Cipollone F., Guagnano M. T., Rossi I., Valeriani E., D'Ardes D., Esposito L., Sestili S., Angelucci E., Mancuso G., Calipari D., Bartone M., Delitala G., Berria M., Delitala A., Muscaritoli M., Molfino A., Petrillo E., Giorgi A., Gracin C., Imbimbo G., Zuccala G., D'Aurizio G., Romanelli G., Volpini A., Lucente D., Manzoni F., Pirozzi A., Zucchelli A., Picardi A., Gentilucci U. V., Gallo P., Dell'Unto C., Bellelli G., Corsi M., Antonucci C., Sidoli C., Principato G., Bonfanti A., Szabo H., Mazzola P., Piazzoli A., Arturi F., Succurro E., Tassone B., Giofre F., Serra M. G., Bleve M. A., Brucato A., De Falco T., Negro E., Brenna M., Trotta L., Squintani G. L., Randi M. L., Fabris F., Bertozzi I., Bogoni G., Rabuini M. V., Prandini T., Ratti F., Zurlo C., Cerruti L., Cosi E., Manfredini R., Fabbian F., Boari B., De Giorgi A., Tiseo R., Paolisso G., Rizzo M. R., Catalano C., Di Meo I., Borghi C., Strocchi E., Ianniello E., Soldati M., Schiavone S., Bragagni A., Leoni F. G., De Sando V., Scarduelli S., Cammarosano M., Pareo I., Sabba C., Vella F. S., Suppressa P., De Vincenzo G. M., Comitangelo A., Amoruso E., Custodero C., Re G., Schilardi A., Loparco F., Fenoglio L., Falcetta A., Giraudo A. V., D'Aniano S., Fracanzani A. L., Tiraboschi S., Cespiati A., Oberti G., Sigon G., Cinque F., Peyvandi F., Rossio R., Colombo G., Agosti P., Pagliaro E., Semproni E., Ciro C., Monzani V., Savojardo V., Ceriani G., Folli C., Pallini G., Montecucco F., Ottonello L., Caserza L., Vischi G., Kassem S., Liberale L., Liberato N. L., Tognin T., Purrello F., Di Pino A., Piro S., Rozzini R., Falanga L., Pisciotta M. S., Bellucci F. B., Buffelli S., Ferrandina C., Mazzeo F., Spazzini E., Cono G., Cesaroni G., Montrucchio G., Peasso P., Favale E., Poletto C., Margaria C., Sanino M., Perri L., Guasti L., Rotunno F., Castiglioni L., Maresca A., Squizzato A., Campiotti L., Grossi A., Diprizio R. D., Dentali F., Bertolotti M., Mussi C., Lancellotti G., Libbra M. V., Galassi M., Grassi Y., Greco A., Bigi E., Pellegrini E., Orlandi L., Dondi G., Carulli L., Sciacqua A., Perticone M., Battaglia R., Maio R., Scozzafava A., Condoleo V., Falbo T., Colangelo L., Filice M., Clausi E., Stanghellini V., Ruggeri E., del Vecchio S., Benzoni I., Salvi A., Leonardi R., Damiani G., Moroncini G., Capeci W., Martino G. P., Biondi L., Pettinari P., Ormas M., Filippini E., Benfaremo D., Romiti R., Ghio R., Col A. D., Minisola S., Cilli M., Labbadia G., Afeltra A., Marigliano B., Pipita M. E., Castellino P., Zanoli L., Gennaro A., Gaudio A., Pignataro S., Mete F., Gino M., Moreo G., Pina G., Ballestrero A., Ferrando F., Gonella R., Cerminara D., Setti P., Traversa C., Scarsi C., Graziella B., Baldassarre S., Fragapani S., Gruden G., Berti F., Famularo G., Tarsitani P., Castello R., Pasino M., Maggio M. G., Ceda G. P., Morganti S., Artoni A., Grossi M., Del Giacco S., Firinu D., Costanzo G., Argiolas G., Paoletti G., Losa F., Montalto G., Licata A., Montalto F. A., Corica F., Basile G., Catalano A., Bellone F., Principato C., Malatino L., Stancanelli B., Terranova V., Di Marca S., Di Quattro R., La Malfa L., Caruso R., Mecocci P., Ruggiero C., Boccardi V., Meschi T., Ticinesi A., Nouvenne A., Minuz P., Fondrieschi L., Imperiale G. N., Morellini S., Pirisi M., Fra G. P., Sola D., Bellan M., Quadri R., Larovere E., Novelli M., Simeone E., Scurti R., Tolloso F., Tarquini R., Valoriani A., Dolenti S., Vannini G., Volpi R., Bocchi P., Vignali A., Harari S., Lonati C., Napoli F., Aiello I., Salvatore T., Monaco L., Ricozzi C., Pilotto A., Indiano I., Gandolfo F., Pasini F. L., Capecchi P. L., Nuti R., Valenti R., Ruvio M., Cappelli S., Palazzuoli A., Bernardi M., Bassi S. L., Santi L., Zaccherini G., Durante V., Tirotta D., Eusebi G., Cattaneo M., Amoruso M. V., Fracasso P., Fasolino C., Tresoldi M., Bozzolo E., Damanti S., Porta M., Armentaro G., Arnone M. I., Barone M., Bertolino L., Bianco S., Binello N., Brancati S., Buonauro A., Cordeddu W., Curcio R., Dalbeni A., D'Agnano S., De Feo M., Donnarumma E., Fei M., Gambino C. G., Giorgini P., Lombardi R., Miceli G., Naccarato P., Noviello S., Olivieri G., Parente R., Pignataro F. S., Poma S., Porceddu E., Pucci G., Ricchio M., Sabena A., Salice M., Santarossa C., Savona A., Savrie C., Scicali R., Stabile M., Talerico G., Talia M., Tassone E. J., Teatini T., Tombolini E., Traversa M., Vettore E., Vignal A., Vilardi L., Villani R., and Vitale F.

Abstract

Background: Hypertension management in older patients represents a challenge, particularly when hospitalized. Objective: The objective of this study is to investigate the determinants and related outcomes of antihypertensive drug prescription in a cohort of older hospitalized patients. Methods: A total of 5671 patients from REPOSI (a prospective multicentre observational register of older Italian in-patients from internal medicine or geriatric wards) were considered; 4377 (77.2%) were hypertensive. Minimum treatment (MT) for hypertension was defined according to the 2018 ESC guidelines [an angiotensin-converting-enzyme-inhibitor (ACE-I) or an angiotensin-receptor-blocker (ARB) with a calcium-channel-blocker (CCB) and/or a thiazide diuretic; if >80 years old, an ACE-I or ARB or CCB or thiazide diuretic]. Determinants of MT discontinuation at discharge were assessed. Study outcomes were any cause rehospitalization/all cause death, all-cause death, cardiovascular (CV) hospitalization/death, CV death, non-CV death, evaluated according to the presence of MT at discharge. Results: Hypertensive patients were older than normotensives, with a more impaired functional status, higher burden of comorbidity and polypharmacy. A total of 2233 patients were on MT at admission, 1766 were on MT at discharge. Discontinuation of MT was associated with the presence of comorbidities (lower odds for diabetes, higher odds for chronic kidney disease and dementia). An adjusted multivariable logistic regression analysis showed that MT for hypertension at discharge was associated with lower risk of all-cause death, all-cause death/hospitalization, CV death, CV death/hospitalization and non-CV death. Conclusions: Guidelines-suggested MT for hypertension at discharge is associated with a lower risk of adverse clinical outcomes. Nevertheless, changes in antihypertensive treatment still occur in a significant proportion of older hospitalized patients.

Published
2023

21. Clinical features and outcomes of elderly hospitalised patients with chronic obstructive pulmonary disease, heart failure or both

Author

Crisafulli, E, Sartori, G, Vianello, A, Busti, F, Nobili, A, Mannucci, P, Girelli, D, Sesti, G, Pietrangelo, A, Perticone, F, Violi, F, Corrao, S, Marengoni, A, Tettamanti, M, Pasina, L, Franchi, C, Novella, A, Miglio, G, Galbussera, A, Ardoino, I, Prisco, D, Silvestri, E, Emmi, G, Bettiol, A, Mattioli, I, Biolo, G, Zanetti, M, Bartelloni, G, Zaccari, M, Chiuch, M, Vanoli, M, Grignani, G, Pulixi, E, Pirro, M, Lupattelli, G, Bianconi, V, Alcidi, R, Giotta, A, Mannarino, M, Marchi, G, Barbagallo, M, Dominguez, L, Beneduce, V, Cacioppo, F, Natoli, G, Mularo, S, Raspanti, M, Argano, C, Cavallaro, F, Zoli, M, Matacena, M, Orio, G, Magnolfi, E, Serafini, G, Simili, A, Brunori, M, Lazzari, I, Cappellini, M, Fabio, G, De Amicis, M, De Luca, G, Scaramellini, N, Di Stefano, V, Leoni, S, Seghezzi, S, Di Mauro, A, Maira, D, Mancarella, M, Lucchi, T, Rossi, P, Clerici, M, Bonini, G, Conti, F, Prolo, S, Fabrizi, M, Martelengo, M, Vigani, G, Nicolini, P, Di Sabatino, A, Miceli, E, Lenti, M, Pisati, M, Pitotti, L, Padula, D, Antoci, V, Cambie, G, Pontremoli, R, Beccati, V, Nobili, G, Leoncini, G, Alberto, J, Cattaneo, F, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Guagnano, M, Rossi, I, Valeriani, E, D'Ardes, D, Esposito, L, Sestili, S, Angelucci, E, Mancuso, G, Calipari, D, Bartone, M, Delitala, G, Berria, M, Delitala, A, Muscaritoli, M, Molfino, A, Petrillo, E, Giorgi, A, Gracin, C, Imbimbo, G, Zuccala, G, D'Aurizio, G, Romanelli, G, Volpini, A, Lucente, D, Manzoni, F, Pirozzi, A, Zucchelli, A, Picardi, A, Gentilucci, U, Gallo, P, Dell'Unto, C, Bellelli, G, Corsi, M, Antonucci, C, Sidoli, C, Principato, G, Bonfanti, A, Szabo, H, Mazzola, P, Piazzoli, A, Arturi, F, Succurro, E, Tassone, B, Giofre, F, Serra, M, Bleve, M, Brucato, A, De Falco, T, Negro, E, Brenna, M, Trotta, L, Squintani, G, Randi, M, Fabris, F, Bertozzi, I, Bogoni, G, Rabuini, M, Prandini, T, Ratti, F, Zurlo, C, Cerruti, L, Cosi, E, Manfredini, R, Boari, B, De Giorgi, A, Tiseo, R, Viglione, G, Savrie, C, Paolisso, G, Rizzo, M, Catalano, C, Di Meo, I, Borghi, C, Strocchi, E, Ianniello, E, Soldati, M, Schiavone, S, Bragagni, A, Leoni, F, De Sando, V, Scarduelli, S, Cammarosano, M, Pareo, I, Sabba, C, Vella, F, Suppressa, P, De Vincenzo, G, Comitangelo, A, Amoruso, E, Custodero, C, Re, G, Schilardi, A, Loparco, F, Fenoglio, L, Falcetta, A, Giraudo, A, D'Aniano, S, Fracanzani, A, Tiraboschi, S, Cespiati, A, Oberti, G, Sigon, G, Cinque, F, Peyvandi, F, Rossio, R, Colombo, G, Agosti, P, Pagliaro, E, Semproni, E, Ciro, C, Monzani, V, Savojardo, V, Ceriani, G, Folli, C, Salerno, F, Pallini, G, Montecucco, F, Ottonello, L, Caserza, L, Vischi, G, Kassem, S, Liberale, L, Liberato, N, Tognin, T, Purrello, F, Di Pino, A, Piro, S, Rozzini, R, Falanga, L, Pisciotta, M, Bellucci, F, Buffelli, S, Ferrandina, C, Mazzeo, F, Spazzini, E, Cono, G, Cesaroni, G, Montrucchio, G, Peasso, P, Favale, E, Poletto, C, Margaria, C, Sanino, M, Perri, L, Guasti, L, Rotunno, F, Castiglioni, L, Maresca, A, Squizzato, A, Campiotti, L, Grossi, A, Diprizio, R, Dentali, F, Bertolotti, M, Mussi, C, Lancellotti, G, Libbra, M, Galassi, M, Grassi, Y, Greco, A, Bigi, E, Pellegrini, E, Orlandi, L, Dondi, G, Carulli, L, Sciacqua, A, Perticone, M, Battaglia, R, Maio, R, Scozzafava, A, Condoleo, V, Falbo, T, Colangelo, L, Filice, M, Clausi, E, Stanghellini, V, Ruggeri, E, Del Vecchio, S, Benzoni, I, Salvi, A, Leonardi, R, Damiani, G, Moroncini, G, Capeci, W, Mattioli, M, Martino, G, Biondi, L, Pettinari, P, Ormas, M, Filippini, E, Benfaremo, D, Romiti, R, Ghio, R, Dal Col, A, Minisola, S, Cilli, M, Labbadia, G, Afeltra, A, Marigliano, B, Pipita, M, Castellino, P, Zanoli, L, Gennaro, A, Gaudio, A, Pignataro, S, Mete, F, Gino, M, Moreo, G, Pina, G, Ballestrero, A, Ferrando, F, Gonella, R, Cerminara, D, Setti, P, Traversa, C, Scarsi, C, Graziella, B, Baldassarre, S, Fragapani, S, Gruden, G, Berti, F, Famularo, G, Tarsitani, P, Castello, R, Pasino, M, Gian Paolo Ceda, M, Morganti, S, Artoni, A, Grossi, M, Del Giacco, S, Firinu, D, Costanzo, G, Argiolas, G, Paoletti, G, Losa, F, Montalto, G, Licata, A, Montalto, F, Rizzo, A, Corica, F, Basile, G, Catalano, A, Bellone, F, Principato, C, Malatino, L, Stancanelli, B, Terranova, V, Di Marca, S, Di Quattro, R, La Malfa, L, Caruso, R, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Ticinesi, A, Nouvenne, A, Minuz, P, Fondrieschi, L, Imperiale, G, Morellini, S, Pirisi, M, Fra, G, Sola, D, Bellan, M, Quadri, R, Larovere, E, Novelli, M, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Napoli, F, Aiello, I, Salvatore, T, Monaco, L, Ricozzi, C, Pilotto, A, Indiano, I, Gandolfo, F, Pasini, F, Capecchi, P, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Bernardi, M, Li Bassi, S, Santi, L, Zaccherini, G, Durante, V, Tirotta, D, Eusebi, G, Cattaneo, M, Amoruso, M, Fracasso, P, Fasolino, C, Tresoldi, M, Bozzolo, E, Damanti, S, Porta, M, Crisafulli E., Sartori G., Vianello A., Busti F., Nobili A., Mannucci P. M., Girelli D., Sesti G., Pietrangelo A., Perticone F., Violi F., Corrao S., Marengoni A., Tettamanti M., Pasina L., Franchi C., Novella A., Miglio G., Galbussera A. A., Ardoino I., Prisco D., Silvestri E., Emmi G., Bettiol A., Mattioli I., Biolo G., Zanetti M., Bartelloni G., Zaccari M., Chiuch M., Vanoli M., Grignani G., Pulixi E. A., Pirro M., Lupattelli G., Bianconi V., Alcidi R., Giotta A., Mannarino M. R., Marchi G., Barbagallo M., Dominguez L., Beneduce V., Cacioppo F., Natoli G., Mularo S., Raspanti M., Argano C., Cavallaro F., Zoli M., Matacena M. L., Orio G., Magnolfi E., Serafini G., Simili A., Brunori M., Lazzari I., Cappellini M. D., Fabio G., De Amicis M. M., De Luca G., Scaramellini N., Di Stefano V., Leoni S., Seghezzi S., Di Mauro A. D., Maira D., Mancarella M., Lucchi T., Rossi P. D., Clerici M., Bonini G., Conti F., Prolo S., Fabrizi M., Martelengo M., Vigani G., Nicolini P., Di Sabatino A., Miceli E., Lenti M. V., Pisati M., Pitotti L., Padula D., Antoci V., Cambie G., Pontremoli R., Beccati V., Nobili G., Leoncini G., Alberto J., Cattaneo F., Anastasio L., Sofia L., Carbone M., Cipollone F., Guagnano M. T., Rossi I., Valeriani E., D'Ardes D., Esposito L., Sestili S., Angelucci E., Mancuso G., Calipari D., Bartone M., Delitala G., Berria M., Delitala A., Muscaritoli M., Molfino A., Petrillo E., Giorgi A., Gracin C., Imbimbo G., Zuccala G., D'Aurizio G., Romanelli G., Volpini A., Lucente D., Manzoni F., Pirozzi A., Zucchelli A., Picardi A., Gentilucci U. V., Gallo P., Dell'Unto C., Bellelli G., Corsi M., Antonucci C., Sidoli C., Principato G., Bonfanti A., Szabo H., Mazzola P., Piazzoli A., Arturi F., Succurro E., Tassone B., Giofre F., Serra M. G., Bleve M. A., Brucato A., De Falco T., Negro E., Brenna M., Trotta L., Squintani G. L., Randi M. L., Fabris F., Bertozzi I., Bogoni G., Rabuini M. V., Prandini T., Ratti F., Zurlo C., Cerruti L., Cosi E., Manfredini R., Boari B., De Giorgi A., Tiseo R., Viglione G. M., Savrie C., Paolisso G., Rizzo M. R., Catalano C., Di Meo I., Borghi C., Strocchi E., Ianniello E., Soldati M., Schiavone S., Bragagni A., Leoni F. G., De Sando V., Scarduelli S., Cammarosano M., Pareo I., Sabba C., Vella F. S., Suppressa P., De Vincenzo G. M., Comitangelo A., Amoruso E., Custodero C., Re G., Schilardi A., Loparco F., Fenoglio L., Falcetta A., Giraudo A. V., D'Aniano S., Fracanzani A. L., Tiraboschi S., Cespiati A., Oberti G., Sigon G., Cinque F., Peyvandi F., Rossio R., Colombo G., Agosti P., Pagliaro E., Semproni E., Ciro C., Monzani V., Savojardo V., Ceriani G., Folli C., Salerno F., Pallini G., Montecucco F., Ottonello L., Caserza L., Vischi G., Kassem S., Liberale L., Liberato N. L., Tognin T., Purrello F., Di Pino A., Piro S., Rozzini R., Falanga L., Pisciotta M. S., Bellucci F. B., Buffelli S., Ferrandina C., Mazzeo F., Spazzini E., Cono G., Cesaroni G., Montrucchio G., Peasso P., Favale E., Poletto C., Margaria C., Sanino M., Perri L., Guasti L., Rotunno F., Castiglioni L., Maresca A., Squizzato A., Campiotti L., Grossi A., Diprizio R. D., Dentali F., Bertolotti M., Mussi C., Lancellotti G., Libbra M. V., Galassi M., Grassi Y., Greco A., Bigi E., Pellegrini E., Orlandi L., Dondi G., Carulli L., Sciacqua A., Perticone M., Battaglia R., Maio R., Scozzafava A., Condoleo V., Falbo T., Colangelo L., Filice M., Clausi E., Stanghellini V., Ruggeri E., Del Vecchio S., Benzoni I., Salvi A., Leonardi R., Damiani G., Moroncini G., Capeci W., Mattioli M., Martino G. P., Biondi L., Pettinari P., Ormas M., Filippini E., Benfaremo D., Romiti R., Ghio R., Dal Col A., Minisola S., Cilli M., Labbadia G., Afeltra A., Marigliano B., Pipita M. E., Castellino P., Zanoli L., Gennaro A., Gaudio A., Pignataro S., Mete F., Gino M., Moreo G., Pina G., Ballestrero A., Ferrando F., Gonella R., Cerminara D., Setti P., Traversa C., Scarsi C., Graziella B., Baldassarre S., Fragapani S., Gruden G., Berti F., Famularo G., Tarsitani P., Castello R., Pasino M., Gian Paolo Ceda M. G. M., Morganti S., Artoni A., Grossi M., Del Giacco S., Firinu D., Costanzo G., Argiolas G., Paoletti G., Losa F., Montalto G., Licata A., Montalto F. A., Rizzo A., Corica F., Basile G., Catalano A., Bellone F., Principato C., Malatino L., Stancanelli B., Terranova V., Di Marca S., Di Quattro R., La Malfa L., Caruso R., Mecocci P., Ruggiero C., Boccardi V., Meschi T., Ticinesi A., Nouvenne A., Minuz P., Fondrieschi L., Imperiale G. N., Morellini S., Pirisi M., Fra G. P., Sola D., Bellan M., Quadri R., Larovere E., Novelli M., Simeone E., Scurti R., Tolloso F., Tarquini R., Valoriani A., Dolenti S., Vannini G., Volpi R., Bocchi P., Vignali A., Harari S., Lonati C., Napoli F., Aiello I., Salvatore T., Monaco L., Ricozzi C., Pilotto A., Indiano I., Gandolfo F., Pasini F. L., Capecchi P. L., Nuti R., Valenti R., Ruvio M., Cappelli S., Palazzuoli A., Bernardi M., Li Bassi S., Santi L., Zaccherini G., Durante V., Tirotta D., Eusebi G., Cattaneo M., Amoruso M. V., Fracasso P., Fasolino C., Tresoldi M., Bozzolo E., Damanti S., Porta M., Crisafulli, E, Sartori, G, Vianello, A, Busti, F, Nobili, A, Mannucci, P, Girelli, D, Sesti, G, Pietrangelo, A, Perticone, F, Violi, F, Corrao, S, Marengoni, A, Tettamanti, M, Pasina, L, Franchi, C, Novella, A, Miglio, G, Galbussera, A, Ardoino, I, Prisco, D, Silvestri, E, Emmi, G, Bettiol, A, Mattioli, I, Biolo, G, Zanetti, M, Bartelloni, G, Zaccari, M, Chiuch, M, Vanoli, M, Grignani, G, Pulixi, E, Pirro, M, Lupattelli, G, Bianconi, V, Alcidi, R, Giotta, A, Mannarino, M, Marchi, G, Barbagallo, M, Dominguez, L, Beneduce, V, Cacioppo, F, Natoli, G, Mularo, S, Raspanti, M, Argano, C, Cavallaro, F, Zoli, M, Matacena, M, Orio, G, Magnolfi, E, Serafini, G, Simili, A, Brunori, M, Lazzari, I, Cappellini, M, Fabio, G, De Amicis, M, De Luca, G, Scaramellini, N, Di Stefano, V, Leoni, S, Seghezzi, S, Di Mauro, A, Maira, D, Mancarella, M, Lucchi, T, Rossi, P, Clerici, M, Bonini, G, Conti, F, Prolo, S, Fabrizi, M, Martelengo, M, Vigani, G, Nicolini, P, Di Sabatino, A, Miceli, E, Lenti, M, Pisati, M, Pitotti, L, Padula, D, Antoci, V, Cambie, G, Pontremoli, R, Beccati, V, Nobili, G, Leoncini, G, Alberto, J, Cattaneo, F, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Guagnano, M, Rossi, I, Valeriani, E, D'Ardes, D, Esposito, L, Sestili, S, Angelucci, E, Mancuso, G, Calipari, D, Bartone, M, Delitala, G, Berria, M, Delitala, A, Muscaritoli, M, Molfino, A, Petrillo, E, Giorgi, A, Gracin, C, Imbimbo, G, Zuccala, G, D'Aurizio, G, Romanelli, G, Volpini, A, Lucente, D, Manzoni, F, Pirozzi, A, Zucchelli, A, Picardi, A, Gentilucci, U, Gallo, P, Dell'Unto, C, Bellelli, G, Corsi, M, Antonucci, C, Sidoli, C, Principato, G, Bonfanti, A, Szabo, H, Mazzola, P, Piazzoli, A, Arturi, F, Succurro, E, Tassone, B, Giofre, F, Serra, M, Bleve, M, Brucato, A, De Falco, T, Negro, E, Brenna, M, Trotta, L, Squintani, G, Randi, M, Fabris, F, Bertozzi, I, Bogoni, G, Rabuini, M, Prandini, T, Ratti, F, Zurlo, C, Cerruti, L, Cosi, E, Manfredini, R, Boari, B, De Giorgi, A, Tiseo, R, Viglione, G, Savrie, C, Paolisso, G, Rizzo, M, Catalano, C, Di Meo, I, Borghi, C, Strocchi, E, Ianniello, E, Soldati, M, Schiavone, S, Bragagni, A, Leoni, F, De Sando, V, Scarduelli, S, Cammarosano, M, Pareo, I, Sabba, C, Vella, F, Suppressa, P, De Vincenzo, G, Comitangelo, A, Amoruso, E, Custodero, C, Re, G, Schilardi, A, Loparco, F, Fenoglio, L, Falcetta, A, Giraudo, A, D'Aniano, S, Fracanzani, A, Tiraboschi, S, Cespiati, A, Oberti, G, Sigon, G, Cinque, F, Peyvandi, F, Rossio, R, Colombo, G, Agosti, P, Pagliaro, E, Semproni, E, Ciro, C, Monzani, V, Savojardo, V, Ceriani, G, Folli, C, Salerno, F, Pallini, G, Montecucco, F, Ottonello, L, Caserza, L, Vischi, G, Kassem, S, Liberale, L, Liberato, N, Tognin, T, Purrello, F, Di Pino, A, Piro, S, Rozzini, R, Falanga, L, Pisciotta, M, Bellucci, F, Buffelli, S, Ferrandina, C, Mazzeo, F, Spazzini, E, Cono, G, Cesaroni, G, Montrucchio, G, Peasso, P, Favale, E, Poletto, C, Margaria, C, Sanino, M, Perri, L, Guasti, L, Rotunno, F, Castiglioni, L, Maresca, A, Squizzato, A, Campiotti, L, Grossi, A, Diprizio, R, Dentali, F, Bertolotti, M, Mussi, C, Lancellotti, G, Libbra, M, Galassi, M, Grassi, Y, Greco, A, Bigi, E, Pellegrini, E, Orlandi, L, Dondi, G, Carulli, L, Sciacqua, A, Perticone, M, Battaglia, R, Maio, R, Scozzafava, A, Condoleo, V, Falbo, T, Colangelo, L, Filice, M, Clausi, E, Stanghellini, V, Ruggeri, E, Del Vecchio, S, Benzoni, I, Salvi, A, Leonardi, R, Damiani, G, Moroncini, G, Capeci, W, Mattioli, M, Martino, G, Biondi, L, Pettinari, P, Ormas, M, Filippini, E, Benfaremo, D, Romiti, R, Ghio, R, Dal Col, A, Minisola, S, Cilli, M, Labbadia, G, Afeltra, A, Marigliano, B, Pipita, M, Castellino, P, Zanoli, L, Gennaro, A, Gaudio, A, Pignataro, S, Mete, F, Gino, M, Moreo, G, Pina, G, Ballestrero, A, Ferrando, F, Gonella, R, Cerminara, D, Setti, P, Traversa, C, Scarsi, C, Graziella, B, Baldassarre, S, Fragapani, S, Gruden, G, Berti, F, Famularo, G, Tarsitani, P, Castello, R, Pasino, M, Gian Paolo Ceda, M, Morganti, S, Artoni, A, Grossi, M, Del Giacco, S, Firinu, D, Costanzo, G, Argiolas, G, Paoletti, G, Losa, F, Montalto, G, Licata, A, Montalto, F, Rizzo, A, Corica, F, Basile, G, Catalano, A, Bellone, F, Principato, C, Malatino, L, Stancanelli, B, Terranova, V, Di Marca, S, Di Quattro, R, La Malfa, L, Caruso, R, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Ticinesi, A, Nouvenne, A, Minuz, P, Fondrieschi, L, Imperiale, G, Morellini, S, Pirisi, M, Fra, G, Sola, D, Bellan, M, Quadri, R, Larovere, E, Novelli, M, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Napoli, F, Aiello, I, Salvatore, T, Monaco, L, Ricozzi, C, Pilotto, A, Indiano, I, Gandolfo, F, Pasini, F, Capecchi, P, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Bernardi, M, Li Bassi, S, Santi, L, Zaccherini, G, Durante, V, Tirotta, D, Eusebi, G, Cattaneo, M, Amoruso, M, Fracasso, P, Fasolino, C, Tresoldi, M, Bozzolo, E, Damanti, S, Porta, M, Crisafulli E., Sartori G., Vianello A., Busti F., Nobili A., Mannucci P. M., Girelli D., Sesti G., Pietrangelo A., Perticone F., Violi F., Corrao S., Marengoni A., Tettamanti M., Pasina L., Franchi C., Novella A., Miglio G., Galbussera A. A., Ardoino I., Prisco D., Silvestri E., Emmi G., Bettiol A., Mattioli I., Biolo G., Zanetti M., Bartelloni G., Zaccari M., Chiuch M., Vanoli M., Grignani G., Pulixi E. A., Pirro M., Lupattelli G., Bianconi V., Alcidi R., Giotta A., Mannarino M. R., Marchi G., Barbagallo M., Dominguez L., Beneduce V., Cacioppo F., Natoli G., Mularo S., Raspanti M., Argano C., Cavallaro F., Zoli M., Matacena M. L., Orio G., Magnolfi E., Serafini G., Simili A., Brunori M., Lazzari I., Cappellini M. D., Fabio G., De Amicis M. M., De Luca G., Scaramellini N., Di Stefano V., Leoni S., Seghezzi S., Di Mauro A. D., Maira D., Mancarella M., Lucchi T., Rossi P. D., Clerici M., Bonini G., Conti F., Prolo S., Fabrizi M., Martelengo M., Vigani G., Nicolini P., Di Sabatino A., Miceli E., Lenti M. V., Pisati M., Pitotti L., Padula D., Antoci V., Cambie G., Pontremoli R., Beccati V., Nobili G., Leoncini G., Alberto J., Cattaneo F., Anastasio L., Sofia L., Carbone M., Cipollone F., Guagnano M. T., Rossi I., Valeriani E., D'Ardes D., Esposito L., Sestili S., Angelucci E., Mancuso G., Calipari D., Bartone M., Delitala G., Berria M., Delitala A., Muscaritoli M., Molfino A., Petrillo E., Giorgi A., Gracin C., Imbimbo G., Zuccala G., D'Aurizio G., Romanelli G., Volpini A., Lucente D., Manzoni F., Pirozzi A., Zucchelli A., Picardi A., Gentilucci U. V., Gallo P., Dell'Unto C., Bellelli G., Corsi M., Antonucci C., Sidoli C., Principato G., Bonfanti A., Szabo H., Mazzola P., Piazzoli A., Arturi F., Succurro E., Tassone B., Giofre F., Serra M. G., Bleve M. A., Brucato A., De Falco T., Negro E., Brenna M., Trotta L., Squintani G. L., Randi M. L., Fabris F., Bertozzi I., Bogoni G., Rabuini M. V., Prandini T., Ratti F., Zurlo C., Cerruti L., Cosi E., Manfredini R., Boari B., De Giorgi A., Tiseo R., Viglione G. M., Savrie C., Paolisso G., Rizzo M. R., Catalano C., Di Meo I., Borghi C., Strocchi E., Ianniello E., Soldati M., Schiavone S., Bragagni A., Leoni F. G., De Sando V., Scarduelli S., Cammarosano M., Pareo I., Sabba C., Vella F. S., Suppressa P., De Vincenzo G. M., Comitangelo A., Amoruso E., Custodero C., Re G., Schilardi A., Loparco F., Fenoglio L., Falcetta A., Giraudo A. V., D'Aniano S., Fracanzani A. L., Tiraboschi S., Cespiati A., Oberti G., Sigon G., Cinque F., Peyvandi F., Rossio R., Colombo G., Agosti P., Pagliaro E., Semproni E., Ciro C., Monzani V., Savojardo V., Ceriani G., Folli C., Salerno F., Pallini G., Montecucco F., Ottonello L., Caserza L., Vischi G., Kassem S., Liberale L., Liberato N. L., Tognin T., Purrello F., Di Pino A., Piro S., Rozzini R., Falanga L., Pisciotta M. S., Bellucci F. B., Buffelli S., Ferrandina C., Mazzeo F., Spazzini E., Cono G., Cesaroni G., Montrucchio G., Peasso P., Favale E., Poletto C., Margaria C., Sanino M., Perri L., Guasti L., Rotunno F., Castiglioni L., Maresca A., Squizzato A., Campiotti L., Grossi A., Diprizio R. D., Dentali F., Bertolotti M., Mussi C., Lancellotti G., Libbra M. V., Galassi M., Grassi Y., Greco A., Bigi E., Pellegrini E., Orlandi L., Dondi G., Carulli L., Sciacqua A., Perticone M., Battaglia R., Maio R., Scozzafava A., Condoleo V., Falbo T., Colangelo L., Filice M., Clausi E., Stanghellini V., Ruggeri E., Del Vecchio S., Benzoni I., Salvi A., Leonardi R., Damiani G., Moroncini G., Capeci W., Mattioli M., Martino G. P., Biondi L., Pettinari P., Ormas M., Filippini E., Benfaremo D., Romiti R., Ghio R., Dal Col A., Minisola S., Cilli M., Labbadia G., Afeltra A., Marigliano B., Pipita M. E., Castellino P., Zanoli L., Gennaro A., Gaudio A., Pignataro S., Mete F., Gino M., Moreo G., Pina G., Ballestrero A., Ferrando F., Gonella R., Cerminara D., Setti P., Traversa C., Scarsi C., Graziella B., Baldassarre S., Fragapani S., Gruden G., Berti F., Famularo G., Tarsitani P., Castello R., Pasino M., Gian Paolo Ceda M. G. M., Morganti S., Artoni A., Grossi M., Del Giacco S., Firinu D., Costanzo G., Argiolas G., Paoletti G., Losa F., Montalto G., Licata A., Montalto F. A., Rizzo A., Corica F., Basile G., Catalano A., Bellone F., Principato C., Malatino L., Stancanelli B., Terranova V., Di Marca S., Di Quattro R., La Malfa L., Caruso R., Mecocci P., Ruggiero C., Boccardi V., Meschi T., Ticinesi A., Nouvenne A., Minuz P., Fondrieschi L., Imperiale G. N., Morellini S., Pirisi M., Fra G. P., Sola D., Bellan M., Quadri R., Larovere E., Novelli M., Simeone E., Scurti R., Tolloso F., Tarquini R., Valoriani A., Dolenti S., Vannini G., Volpi R., Bocchi P., Vignali A., Harari S., Lonati C., Napoli F., Aiello I., Salvatore T., Monaco L., Ricozzi C., Pilotto A., Indiano I., Gandolfo F., Pasini F. L., Capecchi P. L., Nuti R., Valenti R., Ruvio M., Cappelli S., Palazzuoli A., Bernardi M., Li Bassi S., Santi L., Zaccherini G., Durante V., Tirotta D., Eusebi G., Cattaneo M., Amoruso M. V., Fracasso P., Fasolino C., Tresoldi M., Bozzolo E., Damanti S., and Porta M.

Abstract

Background and objective: Chronic obstructive pulmonary disease (COPD) and heart failure (HF) mutually increase the risk of being present in the same patient, especially if older. Whether or not this coexistence may be associated with a worse prognosis is debated. Therefore, employing data derived from the REPOSI register, we evaluated the clinical features and outcomes in a population of elderly patients admitted to internal medicine wards and having COPD, HF or COPD + HF. Methods: We measured socio-demographic and anthropometric characteristics, severity and prevalence of comorbidities, clinical and laboratory features during hospitalization, mood disorders, functional independence, drug prescriptions and discharge destination. The primary study outcome was the risk of death. Results: We considered 2,343 elderly hospitalized patients (median age 81 years), of whom 1,154 (49%) had COPD, 813 (35%) HF, and 376 (16%) COPD + HF. Patients with COPD + HF had different characteristics than those with COPD or HF, such as a higher prevalence of previous hospitalizations, comorbidities (especially chronic kidney disease), higher respiratory rate at admission and number of prescribed drugs. Patients with COPD + HF (hazard ratio HR 1.74, 95% confidence intervals CI 1.16–2.61) and patients with dementia (HR 1.75, 95% CI 1.06–2.90) had a higher risk of death at one year. The Kaplan–Meier curves showed a higher mortality risk in the group of patients with COPD + HF for all causes (p = 0.010), respiratory causes (p = 0.006), cardiovascular causes (p = 0.046) and respiratory plus cardiovascular causes (p = 0.009). Conclusion: In this real-life cohort of hospitalized elderly patients, the coexistence of COPD and HF significantly worsened prognosis at one year. This finding may help to better define the care needs of this population.

Published
2023

23. Statins, ACE/ARBs drug use, and risk of pneumonia in hospitalized older patients: a retrospective cohort study.

Author

Franchi, Carlotta, Rossio, Raffaella, Mandelli, Sara, Ardoino, Ilaria, Nobili, Alessandro, Peyvandi, Flora, Mannucci, Pier Mannuccio, Sesti, Giorgio, Pietrangelo, Antonello, Perticone, Francesco, Violi, Francesco, Corrao, Salvatore, Marengoni, Alessandra, Tettamanti, Mauro, Pasina, Luca, Novella, Alessio, Miglio, Gabriella, Galbussera, Alessia Antonella, Cantiero, Silvia, and Prisco, Domenico

Abstract

The aims of this study is to evaluate the association between angiotensin-converting enzyme inhibitor (ACE-I), angiotensin II receptor blocker (ARBs) and/or statin use with the risk of pneumonia, as well as and with in-hospital and short-term outpatient mortality in hospitalized older patients with pneumonia. Patients aged 65 years or older hospitalized in internal medicine and/or geriatric wards throughout Italy and enrolled in the REPOSI (REgistro Politerapuie SIMI–Società Italiana di Medicina Interna) register from 2010 to 2019 were screened to assess the diagnosis of pneumonia and classified on whether or not they were prescribed with at least one drug among ACE-I, ARBs, and/or statins. Further study outcomes were mortality during hospital stay and at 3 months after hospital discharge. Among 5717 cases included (of whom 18.0% with pneumonia), 2915 (51.0%) were prescribed at least one drug among ACE-I, ARBs, and statins. An inverse association was found between treatment with ACE-I or ARBs and pneumonia (OR = 0.79, 95% CI 0.65–0.95). A higher effect was found among patients treated with ACE-I or ARBs in combination with statins (OR = 0.67, 95% CI 0.52–0.85). This study confirmed in the real-world setting that these largely used medications may reduce the risk of pneumonia in older people, who chronically take them for cardiovascular conditions. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Mild anemia and 11- to 15-year mortality risk in young-old and old-old: Results from two population-based cohort studies

Author

Alessia A. Galbussera, Sara Mandelli, Stefano Rosso, Roberto Zanetti, Marianna Rossi, Adriano Giacomin, Paolo Detoma, Emma Riva, Mauro Tettamanti, Matteo G. Della Porta, and Ugo Lucca

Subjects
Medicine, Science
Abstract

Background Mild anemia is a frequent although often overlooked finding in old age. Nevertheless, in recent years anemia has been linked to several adverse outcomes in the elderly population. Objective of the study was to investigate the association of mild anemia (hemoglobin concentrations: 10.0–11.9/12.9 g/dL in women/men) with all-cause mortality over 11–15 years and the effect of change in anemia status on mortality in young-old (65–84 years) and old-old (80+ years). Methods The Health and Anemia and Monzino 80-plus are two door-to-door, prospective population-based studies that included residents aged 65-plus years in Biella municipality and 80-plus years in Varese province, Italy. No exclusion criteria were used. Results Among 4,494 young-old and 1,842 old-old, mortality risk over 15/11 years was significantly higher in individuals with mild anemia compared with those without (young-old: fully-adjusted HR: 1.35, 95%CI, 1.15–1.58; old-old: fully-adjusted HR: 1.28, 95%CI, 1.14–1.44). Results were similar in the disease-free subpopulation (age, sex, education, smoking history, and alcohol consumption adjusted HR: 1.54, 95%CI, 1.02–2.34). Both age groups showed a dose-response relationship between anemia severity and mortality (P for trend Conclusions Findings from these two large prospective population-based studies consistently suggest an independent, long-term impact of mild anemia on survival at older ages.

Published
2021

27. Patient-Reported Symptoms and Sequelae 12 Months After COVID-19 in Hospitalized Adults: A Multicenter Long-Term Follow-Up Study

Author

Comelli, A, Viero, G, Bettini, G, Nobili, A, Tettamanti, M, Galbussera, A, Muscatello, A, Mantero, M, Canetta, C, Martinelli Boneschi, F, Arighi, A, Brambilla, P, Vecchi, M, Lampertico, P, Bonfanti, P, Contoli, M, Blasi, F, Gori, A, Bandera, A, Comelli, Agnese, Viero, Giulia, Bettini, Greta, Nobili, Alessandro, Tettamanti, Mauro, Galbussera, Alessia Antonella, Muscatello, Antonio, Mantero, Marco, Canetta, Ciro, Martinelli Boneschi, Filippo, Arighi, Andrea, Brambilla, Paolo, Vecchi, Maurizio, Lampertico, Pietro, Bonfanti, Paolo, Contoli, Marco, Blasi, Francesco, Gori, Andrea, Bandera, Alessandra, Comelli, A, Viero, G, Bettini, G, Nobili, A, Tettamanti, M, Galbussera, A, Muscatello, A, Mantero, M, Canetta, C, Martinelli Boneschi, F, Arighi, A, Brambilla, P, Vecchi, M, Lampertico, P, Bonfanti, P, Contoli, M, Blasi, F, Gori, A, Bandera, A, Comelli, Agnese, Viero, Giulia, Bettini, Greta, Nobili, Alessandro, Tettamanti, Mauro, Galbussera, Alessia Antonella, Muscatello, Antonio, Mantero, Marco, Canetta, Ciro, Martinelli Boneschi, Filippo, Arighi, Andrea, Brambilla, Paolo, Vecchi, Maurizio, Lampertico, Pietro, Bonfanti, Paolo, Contoli, Marco, Blasi, Francesco, Gori, Andrea, and Bandera, Alessandra

Abstract

Objective: Our knowledge on the long-term consequences of COVID-19 is still scarce despite the clinical relevance of persisting syndrome. The aim of this study was to analyze patient-reported outcomes, including assessment by specific questionnaires of health impairment and symptoms. Methods: This is a prospective, observational and multicenter cohort study coordinated by Fondazione IRCSS Ca' Granda Ospedale Maggiore Policlinico di Milano and Istituto di Ricerche Farmacologiche Mario Negri IRCCS including eight hospitals located in North and Central Italy. A telephone interview to assess rehospitalization, access to health care resources, general health status subjective evaluation, and symptoms was performed at 12 months after the discharge in patients admitted to hospital because of COVID-19 from February 2020 to the end of May 2020. Results: Among the 776 patients discharged alive, 44 (5.7%) died, 456 subjects (58.8%) completed the questionnaire and 276 (35.6%) were not reachable or refused to join the telephone interview. The mean age of the study population was 59.4 years (SD 14.1), 69.8% of individuals needed oxygen support during hospitalization and 10.4% were admitted to ICU. Overall, 91.7% of participants reported at least one symptom/sequela at 12 months. Exertional dyspnea (71.7%), fatigue (54.6%), and gastrointestinal symptoms (32.8%) were the most reported ones. Health issues after discharge including hospitalization or access to emergency room were described by 19.4% of subjects. Female and presence of comorbidities were independent predictors of whealth impairment and presence of ≥2 symptoms/sequelae after 12 months from hospitalization for COVID-19. Conclusions: Patient-reported symptoms and sequelae, principally dyspnea and fatigue, are found in most individuals even 12 months from COVID-19 hospitalization. Long-term follow-up based on patient-centered outcome can contribute to plan tailored interventions.

Published
2022

28. External validation of risk scores to predict in-hospital mortality in patients hospitalized due to coronavirus disease 2019

Author

Hassan, S, Ramspek, C, Ferrari, B, van Diepen, M, Rossio, R, Knevel, R, la Mura, V, Artoni, A, Martinelli, I, Bandera, A, Nobili, A, Gori, A, Blasi, F, Canetta, C, Montano, N, Rosendaal, F, Peyvandi, F, Bosari, S, Scudeller, L, Fusetti, G, Rusconi, L, Dell'Orto, S, Prati, D, Valenti, L, Giovannelli, S, Manunta, M, Lamorte, G, Ferarri, F, Muscatello, A, Mangioni, D, Alagna, L, Bozzi, G, Lombardi, A, Ungaro, R, Ancona, G, Zuglian, G, Bolis, M, Iannotti, N, Ludovisi, S, Comelli, A, Renisi, G, Biscarini, S, Castelli, V, Palomba, E, Fava, M, Fortina, V, Peri, C, Saltini, P, Viero, G, Itri, T, Ferroni, V, Pastore, V, Massafra, R, Liparoti, A, Muheberimana, T, Giommi, A, Bianco, R, De Azevedo, R, Chitani, G, Gualtierotti, R, Boasi, N, Pagliaro, E, Massimo, C, De Caro, M, Giachi, A, Vigone, B, Bellocchi, C, Carandina, A, Fiorelli, E, Melli, V, Tobaldini, E, Aliberti, S, Spotti, M, Terranova, L, Misuraca, S, D'Adda, A, Fiore, S, Di Pasquale, M, Mantero, M, Contarini, M, Ori, M, Morlacchi, L, Rossetti, V, Gramegna, A, Pappalettera, M, Cavallini, M, Buscemi, A, Vicenzi, M, Rota, I, Costantino, G, Solbiati, M, Furlan, L, Mancarella, M, Colombo, G, Fanin, A, Passarella, M, Monzani, V, Rovellini, A, Barbetta, L, Billi, F, Folli, C, Accordino, S, Maira, D, Hu, C, Motta, I, Scar-Amellini, N, Fracanzani, A, Lombardi, R, Cespiati, A, Cesari, M, Lucchi, T, Proietti, M, Calcaterra, L, Mandelli, C, Coppola, C, Cerizza, A, Maria Pesenti, A, Grasselli, G, Galazzi, A, Tet-Tamanti, M, Monti, I, Galbussera, A, Crisafulli, E, Girelli, D, Maroccia, A, Gabbiani, D, Busti, F, Vianello, A, Biondan, M, Sartori, F, Faverio, P, Pesci, A, Zucchetti, S, Bonfanti, P, Rossi, M, Beretta, I, Spolti, A, Harari, S, Elia, D, Cassandro, R, Caminati, A, Cipollone, F, Guagnano, M, D'Ardes, D, Rossi, I, Vezzani, F, Spanevello, A, Cherubino, F, Visca, D, Contoli, M, Papi, A, Morandi, L, Battistini, N, Luigi Moreo, G, Iannuzzi, P, Fumagalli, D, Leone, S, Oud, J, Baysan, M, Wigb, J, van Heurn, L, ter Haar, S, Toppenberg, A, Heerdink, L, van IJlzinga Veenstra, A, Eikenboom, A, Wubbolts, J, Uzorka, J, Lijferink, W, Meier, R, de Jonge, I, Arbous, S, de Boer, M, van der Bom, J, Dekkers, O, Hassan S., Ramspek C. L., Ferrari B., van Diepen M., Rossio R., Knevel R., la Mura V., Artoni A., Martinelli I., Bandera A., Nobili A., Gori A., Blasi F., Canetta C., Montano N., Rosendaal F. R., Peyvandi F., Bosari S., Scudeller L., Fusetti G., Rusconi L., Dell'Orto S., Prati D., Valenti L., Giovannelli S., Manunta M., Lamorte G., Ferarri F., Muscatello A., Mangioni D., Alagna L., Bozzi G., Lombardi A., Ungaro R., Ancona G., Zuglian G., Bolis M., Iannotti N., Ludovisi S., Comelli A., Renisi G., Biscarini S., Castelli V., Palomba E., Fava M., Fortina V., Peri C. A., Saltini P., Viero G., Itri T., Ferroni V., Pastore V., Massafra R., Liparoti A., Muheberimana T., Giommi A., Bianco R., De Azevedo R. M., Chitani G. E., Gualtierotti R., Boasi N., Pagliaro E., Massimo C., De Caro M., Giachi A., Vigone B., Bellocchi C., Carandina A., Fiorelli E., Melli V., Tobaldini E., Aliberti S., Spotti M., Terranova L., Misuraca S., D'Adda A., Fiore S. D., Di Pasquale M., Mantero M., Contarini M., Ori M., Morlacchi L., Rossetti V., Gramegna A., Pappalettera M., Cavallini M., Buscemi A., Vicenzi M., Rota I., Costantino G., Solbiati M., Furlan L., Mancarella M., Colombo G., Fanin A., Passarella M., Monzani V., Rovellini A., Barbetta L., Billi F., Folli C., Accordino S., Maira D., Hu C. M., Motta I., Scar-Amellini N., Fracanzani A. L., Lombardi R., Cespiati A., Cesari M., Lucchi T., Proietti M., Calcaterra L., Mandelli C., Coppola C., Cerizza A., Maria Pesenti A., Grasselli G., Galazzi A., Tet-Tamanti M., Monti I., Galbussera A. A., Crisafulli E., Girelli D., Maroccia A., Gabbiani D., Busti F., Vianello A., Biondan M., Sartori F., Faverio P., Pesci A., Zucchetti S., Bonfanti P., Rossi M., Beretta I., Spolti A., Harari S., Elia D., Cassandro R., Caminati A., Cipollone F., Guagnano M. T., D'Ardes D., Rossi I., Vezzani F., Spanevello A., Cherubino F., Visca D., Contoli M., Papi A., Morandi L., Battistini N., Luigi Moreo G., Iannuzzi P., Fumagalli D., Leone S., Oud J. A., Baysan M., Wigb J., van Heurn L. J., ter Haar S. B., Toppenberg A. G. L., Heerdink L., van IJlzinga Veenstra A. A., Eikenboom A. M., Wubbolts J., Uzorka J., Lijferink W., Meier R., de Jonge I. -B., Arbous S. M., de Boer M. G. J., van der Bom J. G., Dekkers O. M., Hassan, S, Ramspek, C, Ferrari, B, van Diepen, M, Rossio, R, Knevel, R, la Mura, V, Artoni, A, Martinelli, I, Bandera, A, Nobili, A, Gori, A, Blasi, F, Canetta, C, Montano, N, Rosendaal, F, Peyvandi, F, Bosari, S, Scudeller, L, Fusetti, G, Rusconi, L, Dell'Orto, S, Prati, D, Valenti, L, Giovannelli, S, Manunta, M, Lamorte, G, Ferarri, F, Muscatello, A, Mangioni, D, Alagna, L, Bozzi, G, Lombardi, A, Ungaro, R, Ancona, G, Zuglian, G, Bolis, M, Iannotti, N, Ludovisi, S, Comelli, A, Renisi, G, Biscarini, S, Castelli, V, Palomba, E, Fava, M, Fortina, V, Peri, C, Saltini, P, Viero, G, Itri, T, Ferroni, V, Pastore, V, Massafra, R, Liparoti, A, Muheberimana, T, Giommi, A, Bianco, R, De Azevedo, R, Chitani, G, Gualtierotti, R, Boasi, N, Pagliaro, E, Massimo, C, De Caro, M, Giachi, A, Vigone, B, Bellocchi, C, Carandina, A, Fiorelli, E, Melli, V, Tobaldini, E, Aliberti, S, Spotti, M, Terranova, L, Misuraca, S, D'Adda, A, Fiore, S, Di Pasquale, M, Mantero, M, Contarini, M, Ori, M, Morlacchi, L, Rossetti, V, Gramegna, A, Pappalettera, M, Cavallini, M, Buscemi, A, Vicenzi, M, Rota, I, Costantino, G, Solbiati, M, Furlan, L, Mancarella, M, Colombo, G, Fanin, A, Passarella, M, Monzani, V, Rovellini, A, Barbetta, L, Billi, F, Folli, C, Accordino, S, Maira, D, Hu, C, Motta, I, Scar-Amellini, N, Fracanzani, A, Lombardi, R, Cespiati, A, Cesari, M, Lucchi, T, Proietti, M, Calcaterra, L, Mandelli, C, Coppola, C, Cerizza, A, Maria Pesenti, A, Grasselli, G, Galazzi, A, Tet-Tamanti, M, Monti, I, Galbussera, A, Crisafulli, E, Girelli, D, Maroccia, A, Gabbiani, D, Busti, F, Vianello, A, Biondan, M, Sartori, F, Faverio, P, Pesci, A, Zucchetti, S, Bonfanti, P, Rossi, M, Beretta, I, Spolti, A, Harari, S, Elia, D, Cassandro, R, Caminati, A, Cipollone, F, Guagnano, M, D'Ardes, D, Rossi, I, Vezzani, F, Spanevello, A, Cherubino, F, Visca, D, Contoli, M, Papi, A, Morandi, L, Battistini, N, Luigi Moreo, G, Iannuzzi, P, Fumagalli, D, Leone, S, Oud, J, Baysan, M, Wigb, J, van Heurn, L, ter Haar, S, Toppenberg, A, Heerdink, L, van IJlzinga Veenstra, A, Eikenboom, A, Wubbolts, J, Uzorka, J, Lijferink, W, Meier, R, de Jonge, I, Arbous, S, de Boer, M, van der Bom, J, Dekkers, O, Hassan S., Ramspek C. L., Ferrari B., van Diepen M., Rossio R., Knevel R., la Mura V., Artoni A., Martinelli I., Bandera A., Nobili A., Gori A., Blasi F., Canetta C., Montano N., Rosendaal F. R., Peyvandi F., Bosari S., Scudeller L., Fusetti G., Rusconi L., Dell'Orto S., Prati D., Valenti L., Giovannelli S., Manunta M., Lamorte G., Ferarri F., Muscatello A., Mangioni D., Alagna L., Bozzi G., Lombardi A., Ungaro R., Ancona G., Zuglian G., Bolis M., Iannotti N., Ludovisi S., Comelli A., Renisi G., Biscarini S., Castelli V., Palomba E., Fava M., Fortina V., Peri C. A., Saltini P., Viero G., Itri T., Ferroni V., Pastore V., Massafra R., Liparoti A., Muheberimana T., Giommi A., Bianco R., De Azevedo R. M., Chitani G. E., Gualtierotti R., Boasi N., Pagliaro E., Massimo C., De Caro M., Giachi A., Vigone B., Bellocchi C., Carandina A., Fiorelli E., Melli V., Tobaldini E., Aliberti S., Spotti M., Terranova L., Misuraca S., D'Adda A., Fiore S. D., Di Pasquale M., Mantero M., Contarini M., Ori M., Morlacchi L., Rossetti V., Gramegna A., Pappalettera M., Cavallini M., Buscemi A., Vicenzi M., Rota I., Costantino G., Solbiati M., Furlan L., Mancarella M., Colombo G., Fanin A., Passarella M., Monzani V., Rovellini A., Barbetta L., Billi F., Folli C., Accordino S., Maira D., Hu C. M., Motta I., Scar-Amellini N., Fracanzani A. L., Lombardi R., Cespiati A., Cesari M., Lucchi T., Proietti M., Calcaterra L., Mandelli C., Coppola C., Cerizza A., Maria Pesenti A., Grasselli G., Galazzi A., Tet-Tamanti M., Monti I., Galbussera A. A., Crisafulli E., Girelli D., Maroccia A., Gabbiani D., Busti F., Vianello A., Biondan M., Sartori F., Faverio P., Pesci A., Zucchetti S., Bonfanti P., Rossi M., Beretta I., Spolti A., Harari S., Elia D., Cassandro R., Caminati A., Cipollone F., Guagnano M. T., D'Ardes D., Rossi I., Vezzani F., Spanevello A., Cherubino F., Visca D., Contoli M., Papi A., Morandi L., Battistini N., Luigi Moreo G., Iannuzzi P., Fumagalli D., Leone S., Oud J. A., Baysan M., Wigb J., van Heurn L. J., ter Haar S. B., Toppenberg A. G. L., Heerdink L., van IJlzinga Veenstra A. A., Eikenboom A. M., Wubbolts J., Uzorka J., Lijferink W., Meier R., de Jonge I. -B., Arbous S. M., de Boer M. G. J., van der Bom J. G., and Dekkers O. M.

Abstract

Background: The coronavirus disease 2019 (COVID-19) presents an urgent threat to global health. Prediction models that accurately estimate mortality risk in hospitalized patients could assist medical staff in treatment and allocating limited resources. Aims: To externally validate two promising previously published risk scores that predict in-hospital mortality among hospitalized COVID-19 patients. Methods: Two prospective cohorts were available; a cohort of 1028 patients admitted to one of nine hospitals in Lombardy, Italy (the Lombardy cohort) and a cohort of 432 patients admitted to a hospital in Leiden, the Netherlands (the Leiden cohort). The endpoint was in-hospital mortality. All patients were adult and tested COVID-19 PCR-positive. Model discrimination and calibration were assessed. Results: The C-statistic of the 4C mortality score was good in the Lombardy cohort (0.85, 95CI: 0.82−0.89) and in the Leiden cohort (0.87, 95CI: 0.80−0.94). Model calibration was acceptable in the Lombardy cohort but poor in the Leiden cohort due to the model systematically overpredicting the mortality risk for all patients. The C-statistic of the CURB-65 score was good in the Lombardy cohort (0.80, 95CI: 0.75−0.85) and in the Leiden cohort (0.82, 95CI: 0.76−0.88). The mortality rate in the CURB-65 development cohort was much lower than the mortality rate in the Lombardy cohort. A similar but less pronounced trend was found for patients in the Leiden cohort. Conclusion: Although performances did not differ greatly, the 4C mortality score showed the best performance. However, because of quickly changing circumstances, model recalibration may be necessary before using the 4C mortality score.

Published
2022

29. Willingness to share contacts in case of COVID-19 positivity-predictors of collaboration resistance in a nation-wide Italian survey

Author

Bikbov, B, Tettamanti, M, Bikbov, A, D'Avanzo, B, Galbussera, A, Nobili, A, Calamandrei, G, Candini, V, Starace, F, Zarbo, C, de Girolamo, G, Bikbov B, Tettamanti M, Bikbov A, D'Avanzo B, Galbussera AA, Nobili A, Calamandrei G, Candini V, Starace F, Zarbo C, de Girolamo G, Bikbov, B, Tettamanti, M, Bikbov, A, D'Avanzo, B, Galbussera, A, Nobili, A, Calamandrei, G, Candini, V, Starace, F, Zarbo, C, de Girolamo, G, Bikbov B, Tettamanti M, Bikbov A, D'Avanzo B, Galbussera AA, Nobili A, Calamandrei G, Candini V, Starace F, Zarbo C, and de Girolamo G

Abstract

Background The unwillingness to share contacts is one of the least explored aspects of the COVID-19 pandemic. Here we report the factors associated with resistance to collaborate on contact tracing, based on the results of a nation-wide survey conducted in Italy in January-March 2021. Methods and findings The repeated cross-sectional on-line survey was conducted among 7,513 respondents (mean age 45.7, 50.4% women) selected to represent the Italian adult population 18–70 years old. Two groups were defined based on the direct question response expressing (1) unwillingness or (2) willingness to share the names of individuals with whom respondents had contact. We selected 70% of participants (training data set) to produce several multivariable binomial generalized linear models and estimated the proportion of variation explained by the model by McFadden R2, and the model’s discriminatory ability by the index of concordance. Then, we have validated the regression models using the remaining 30% of respondents (testing data set), and identified the best performing model by removing the variables based on their impact on the Akaike information criterion and then evaluating the model predictive accuracy. We also performed a sensitivity analysis using principal component analysis. Overall, 5.5% of the respondents indicated that in case of positive SARS-CoV-2 test they would not share contacts. Of note, this percentage varied from 0.8% to 46.5% depending on the answers to other survey questions. From the 139 questions included in the multivariable analysis, the initial model proposed 20 independent factors that were reduced to the 6 factors with only modest changes in the model performance. The 6-variables model demonstrated good performance in the training (c-index 0.85 and McFadden R2 criteria 0.25) and in the testing data set (93.3% accuracy, AUC 0.78, sensitivity 30.4% and specificity 97.4%). The most influential factors related to unwillingness to share contacts were the

Published
2022

30. Clinical factors associated with death in 3044 COVID-19 patients managed in internal medicine wards in Italy: comment

Author

Bandera, A, Nobili, A, Tettamanti, M, Harari, S, Bosari, S, Mannucci, P, Scudeller, L, Fusetti, G, Rusconi, L, Dell'Orto, S, Prati, D, Valenti, L, Giovannelli, S, Manunta, M, Lamorte, G, Ferrari, F, Gori, A, Muscatello, A, Mangioni, D, Alagna, L, Bozzi, G, Lombardi, A, Ungaro, R, Ancona, G, Zuglian, G, Bolis, M, Iannotti, N, Ludovisi, S, Comelli, A, Renisi, G, Biscarini, S, Castelli, V, Palomba, E, Fava, M, Fortina, V, Peri, C, Saltini, P, Viero, G, Itri, T, Ferroni, V, Pastore, V, Massafra, R, Liparoti, A, Muheberimana, T, Giommi, A, Bianco, R, De Azevedo, R, Chitani, G, Peyvandi, F, Gualtierotti, R, Ferrari, B, Rossio, R, Boasi, N, Pagliaro, E, Massimo, C, De Caro, M, Montano, N, Vigone, B, Bellocchi, C, Carandina, A, Fiorelli, E, Melli, V, Tobaldini, E, Blasi, F, Aliberti, S, Spotti, M, Terranova, L, Misuraca, S, D'Adda, A, Della Fiore, S, Di Pasquale, M, Contarini, M, Ori, M, Morlacchi, L, Rossetti, V, Gramegna, A, Pappalettera, M, Cavallini, M, Buscemi, A, Vicenzi, M, Rota, I, Costantino, G, Solbiati, M, Furlan, L, Mancarella, M, Colombo, G, Fanin, A, Passarella, M, Monzani, V, Canetta, C, Rovellini, A, Barbetta, L, Billi, F, Folli, C, Accordino, S, Maira, D, Hu, C, Motta, I, Scaramellini, N, Fracanzani, A, Lombardi, R, Cespiati, A, Cesari, M, Lucchi, T, Proietti, M, Calcaterra, L, Mandelli, C, Coppola, C, Cerizza, A, Pesenti, A, Grasselli, G, Galazzi, A, Monti, I, Galbussera, A, Crisafulli, E, Girelli, D, Maroccia, A, Gabbiani, D, Busti, F, Vianello, A, Biondan, M, Sartori, F, Faverio, P, Pesci, A, Zucchetti, S, Bonfanti, P, Rossi, M, Beretta, I, Spolti, A, Elia, D, Cassandro, R, Caminati, A, Cipollone, F, Guagnano, M, D'Ardes, D, Rossi, I, Vezzani, F, Spanevello, A, Cherubino, F, Visca, D, Contoli, M, Papi, A, Morandi, L, Battistini, N, Moreo, G, Iannuzzi, P, Fumagalli, D, Leone, S, Bandera A., Nobili A., Tettamanti M., Harari S., Bosari S., Mannucci P. M., Scudeller L., Fusetti G., Rusconi L., Dell'Orto S., Prati D., Valenti L., Giovannelli S., Manunta M., Lamorte G., Ferrari F., Gori A., Muscatello A., Mangioni D., Alagna L., Bozzi G., Lombardi A., Ungaro R., Ancona G., Zuglian G., Bolis M., Iannotti N., Ludovisi S., Comelli A., Renisi G., Biscarini S., Castelli V., Palomba E., Fava M., Fortina V., Peri C. A., Saltini P., Viero G., Itri T., Ferroni V., Pastore V., Massafra R., Liparoti A., Muheberimana T., Giommi A., Bianco R., De Azevedo R. M., Chitani G. E., Peyvandi F., Gualtierotti R., Ferrari B., Rossio R., Boasi N., Pagliaro E., Massimo C., De Caro M., Montano N., Vigone B., Bellocchi C., Carandina A., Fiorelli E., Melli V., Tobaldini E., Blasi F., Aliberti S., Spotti M., Terranova L., Misuraca S., D'Adda A., Della Fiore S., Di Pasquale M., Contarini M. M. M., Ori M., Morlacchi L., Rossetti V., Gramegna A., Pappalettera M., Cavallini M., Buscemi A., Vicenzi M., Rota I., Costantino G., Solbiati M., Furlan L., Mancarella M., Colombo G., Fanin A., Passarella M., Monzani V., Canetta C., Rovellini A., Barbetta L., Billi F., Folli C., Accordino S., Maira D., Hu C. M., Motta I., Scaramellini N., Fracanzani A. L., Lombardi R., Cespiati A., Cesari M., Lucchi T., Proietti M., Calcaterra L., Mandelli C., Coppola C., Cerizza A., Pesenti A. M., Grasselli G., Galazzi A., Monti I., Galbussera A. A., Crisafulli E., Girelli D., Maroccia A., Gabbiani D., Busti F., Vianello A., Biondan M., Sartori F., Faverio P., Pesci A., Zucchetti S., Bonfanti P., Rossi M., Beretta I., Spolti A., Elia D., Cassandro R., Caminati A., Cipollone F., Guagnano M. T., D'Ardes D., Rossi I., Vezzani F., Spanevello A., Cherubino F., Visca D., Contoli M., Papi A., Morandi L., Battistini N., Moreo G. L., Iannuzzi P., Fumagalli D., Leone S., Bandera, A, Nobili, A, Tettamanti, M, Harari, S, Bosari, S, Mannucci, P, Scudeller, L, Fusetti, G, Rusconi, L, Dell'Orto, S, Prati, D, Valenti, L, Giovannelli, S, Manunta, M, Lamorte, G, Ferrari, F, Gori, A, Muscatello, A, Mangioni, D, Alagna, L, Bozzi, G, Lombardi, A, Ungaro, R, Ancona, G, Zuglian, G, Bolis, M, Iannotti, N, Ludovisi, S, Comelli, A, Renisi, G, Biscarini, S, Castelli, V, Palomba, E, Fava, M, Fortina, V, Peri, C, Saltini, P, Viero, G, Itri, T, Ferroni, V, Pastore, V, Massafra, R, Liparoti, A, Muheberimana, T, Giommi, A, Bianco, R, De Azevedo, R, Chitani, G, Peyvandi, F, Gualtierotti, R, Ferrari, B, Rossio, R, Boasi, N, Pagliaro, E, Massimo, C, De Caro, M, Montano, N, Vigone, B, Bellocchi, C, Carandina, A, Fiorelli, E, Melli, V, Tobaldini, E, Blasi, F, Aliberti, S, Spotti, M, Terranova, L, Misuraca, S, D'Adda, A, Della Fiore, S, Di Pasquale, M, Contarini, M, Ori, M, Morlacchi, L, Rossetti, V, Gramegna, A, Pappalettera, M, Cavallini, M, Buscemi, A, Vicenzi, M, Rota, I, Costantino, G, Solbiati, M, Furlan, L, Mancarella, M, Colombo, G, Fanin, A, Passarella, M, Monzani, V, Canetta, C, Rovellini, A, Barbetta, L, Billi, F, Folli, C, Accordino, S, Maira, D, Hu, C, Motta, I, Scaramellini, N, Fracanzani, A, Lombardi, R, Cespiati, A, Cesari, M, Lucchi, T, Proietti, M, Calcaterra, L, Mandelli, C, Coppola, C, Cerizza, A, Pesenti, A, Grasselli, G, Galazzi, A, Monti, I, Galbussera, A, Crisafulli, E, Girelli, D, Maroccia, A, Gabbiani, D, Busti, F, Vianello, A, Biondan, M, Sartori, F, Faverio, P, Pesci, A, Zucchetti, S, Bonfanti, P, Rossi, M, Beretta, I, Spolti, A, Elia, D, Cassandro, R, Caminati, A, Cipollone, F, Guagnano, M, D'Ardes, D, Rossi, I, Vezzani, F, Spanevello, A, Cherubino, F, Visca, D, Contoli, M, Papi, A, Morandi, L, Battistini, N, Moreo, G, Iannuzzi, P, Fumagalli, D, Leone, S, Bandera A., Nobili A., Tettamanti M., Harari S., Bosari S., Mannucci P. M., Scudeller L., Fusetti G., Rusconi L., Dell'Orto S., Prati D., Valenti L., Giovannelli S., Manunta M., Lamorte G., Ferrari F., Gori A., Muscatello A., Mangioni D., Alagna L., Bozzi G., Lombardi A., Ungaro R., Ancona G., Zuglian G., Bolis M., Iannotti N., Ludovisi S., Comelli A., Renisi G., Biscarini S., Castelli V., Palomba E., Fava M., Fortina V., Peri C. A., Saltini P., Viero G., Itri T., Ferroni V., Pastore V., Massafra R., Liparoti A., Muheberimana T., Giommi A., Bianco R., De Azevedo R. M., Chitani G. E., Peyvandi F., Gualtierotti R., Ferrari B., Rossio R., Boasi N., Pagliaro E., Massimo C., De Caro M., Montano N., Vigone B., Bellocchi C., Carandina A., Fiorelli E., Melli V., Tobaldini E., Blasi F., Aliberti S., Spotti M., Terranova L., Misuraca S., D'Adda A., Della Fiore S., Di Pasquale M., Contarini M. M. M., Ori M., Morlacchi L., Rossetti V., Gramegna A., Pappalettera M., Cavallini M., Buscemi A., Vicenzi M., Rota I., Costantino G., Solbiati M., Furlan L., Mancarella M., Colombo G., Fanin A., Passarella M., Monzani V., Canetta C., Rovellini A., Barbetta L., Billi F., Folli C., Accordino S., Maira D., Hu C. M., Motta I., Scaramellini N., Fracanzani A. L., Lombardi R., Cespiati A., Cesari M., Lucchi T., Proietti M., Calcaterra L., Mandelli C., Coppola C., Cerizza A., Pesenti A. M., Grasselli G., Galazzi A., Monti I., Galbussera A. A., Crisafulli E., Girelli D., Maroccia A., Gabbiani D., Busti F., Vianello A., Biondan M., Sartori F., Faverio P., Pesci A., Zucchetti S., Bonfanti P., Rossi M., Beretta I., Spolti A., Elia D., Cassandro R., Caminati A., Cipollone F., Guagnano M. T., D'Ardes D., Rossi I., Vezzani F., Spanevello A., Cherubino F., Visca D., Contoli M., Papi A., Morandi L., Battistini N., Moreo G. L., Iannuzzi P., Fumagalli D., and Leone S.

Published
2022

31. Clinical risk scores for the early prediction of severe outocomes in patients hospitalized for COVID-19: comment

Author

Rossio, R, Tettamanti, M, Nobili, A, Harari, S, Mannucci, P, Bandera, A, Peyvandi, F, Bosari, S, Scudeller, L, Fusetti, G, Rusconi, L, Dell'Orto, S, Prati, D, Valenti, L, Giovannelli, S, Manunta, M, Lamorte, G, Ferrari, F, Gori, A, Muscatello, A, Mangioni, D, Alagna, L, Bozzi, G, Lombardi, A, Ungaro, R, Ancona, G, Zuglian, G, Bolis, M, Iannotti, N, Ludovisi, S, Comelli, A, Renisi, G, Biscarini, S, Castelli, V, Palomba, E, Fava, M, Fortina, V, Peri, C, Saltini, P, Viero, G, Itri, T, Ferroni, V, Pastore, V, Massafra, R, Liparoti, A, Muheberimana, T, Giommi, A, Bianco, R, De Azevedo, R, Chitani, G, Gualtierotti, R, Ferrari, B, Boasi, N, Pagliaro, E, Massimo, C, De Caro, M, Giachi, A, Montano, N, Vigone, B, Bellocchi, C, Carandina, A, Fiorelli, E, Melli, V, Tobaldini, E, Blasi, F, Aliberti, S, Spotti, M, Terranova, L, Misuraca, S, D'Adda, A, Fiore, S, Di Pasquale, M, Mantero, M, Contarini, M, Ori, M, Morlacchi, L, Rossetti, V, Gramegna, A, Pappalettera, M, Cavallini, M, Buscemi, A, Vicenzi, M, Rota, I, Costantino, G, Solbiati, M, Furlan, L, Mancarella, M, Colombo, G, Fanin, A, Passarella, M, Monzani, V, Canetta, C, Rovellini, A, Barbetta, L, Billi, F, Folli, C, Accordino, S, Maira, D, Hu, C, Motta, I, Scaramellini, N, Fracanzani, A, Lombardi, R, Cespiati, A, Cesari, M, Lucchi, T, Proietti, M, Calcaterra, L, Mandelli, C, Coppola, C, Cerizza, A, Pesenti, A, Grasselli, G, Galazzi, A, Monti, I, Galbussera, A, Crisafulli, E, Girelli, D, Maroccia, A, Gabbiani, D, Busti, F, Vianello, A, Biondan, M, Sartori, F, Faverio, P, Pesci, A, Zucchetti, S, Bonfanti, P, Rossi, M, Beretta, I, Spolti, A, Elia, D, Cassandro, R, Caminati, A, Cipollone, F, Guagnano, M, D'Ardes, D, Rossi, I, Vezzani, F, Spanevello, A, Cherubino, F, Visca, D, Contoli, M, Papi, A, Morandi, L, Battistini, N, Moreo, G, Iannuzzi, P, Fumagalli, D, Leone, S, Rossio R., Tettamanti M., Nobili A., Harari S., Mannucci P. M., Bandera A., Peyvandi F., Bosari S., Scudeller L., Fusetti G., Rusconi L., Dell'Orto S., Prati D., Valenti L., Giovannelli S., Manunta M., Lamorte G., Ferrari F., Gori A., Muscatello A., Mangioni D., Alagna L., Bozzi G., Lombardi A., Ungaro R., Ancona G., Zuglian G., Bolis M., Iannotti N., Ludovisi S., Comelli A., Renisi G., Biscarini S., Castelli V., Palomba E., Fava M., Fortina V., Peri C. A., Saltini P., Viero G., Itri T., Ferroni V., Pastore V., Massafra R., Liparoti A., Muheberimana T., Giommi A., Bianco R., De Azevedo R. M., Chitani G. E., Gualtierotti R., Ferrari B., Boasi N., Pagliaro E., Massimo C., De Caro M., Giachi A., Montano N., Vigone B., Bellocchi C., Carandina A., Fiorelli E., Melli V., Tobaldini E., Blasi F., Aliberti S., Spotti M., Terranova L., Misuraca S., D'Adda A., Fiore S. D., Di Pasquale M., Mantero M., Contarini M., Ori M., Morlacchi L., Rossetti V., Gramegna A., Pappalettera M., Cavallini M., Buscemi A., Vicenzi M., Rota I., Costantino G., Solbiati M., Furlan L., Mancarella M., Colombo G., Fanin A., Passarella M., Monzani V., Canetta C., Rovellini A., Barbetta L., Billi F., Folli C., Accordino S., Maira D., Hu C. M., Motta I., Scaramellini N., Fracanzani A. L., Lombardi R., Cespiati A., Cesari M., Lucchi T., Proietti M., Calcaterra L., Mandelli C., Coppola C., Cerizza A., Pesenti A. M., Grasselli G., Galazzi A., Monti I., Galbussera A. A., Crisafulli E., Girelli D., Maroccia A., Gabbiani D., Busti F., Vianello A., Biondan M., Sartori F., Faverio P., Pesci A., Zucchetti S., Bonfanti P., Rossi M., Beretta I., Spolti A., Elia D., Cassandro R., Caminati A., Cipollone F., Guagnano M. T., D'Ardes D., Rossi I., Vezzani F., Spanevello A., Cherubino F., Visca D., Contoli M., Papi A., Morandi L., Battistini N., Moreo G. L., Iannuzzi P., Fumagalli D., Leone S., Rossio, R, Tettamanti, M, Nobili, A, Harari, S, Mannucci, P, Bandera, A, Peyvandi, F, Bosari, S, Scudeller, L, Fusetti, G, Rusconi, L, Dell'Orto, S, Prati, D, Valenti, L, Giovannelli, S, Manunta, M, Lamorte, G, Ferrari, F, Gori, A, Muscatello, A, Mangioni, D, Alagna, L, Bozzi, G, Lombardi, A, Ungaro, R, Ancona, G, Zuglian, G, Bolis, M, Iannotti, N, Ludovisi, S, Comelli, A, Renisi, G, Biscarini, S, Castelli, V, Palomba, E, Fava, M, Fortina, V, Peri, C, Saltini, P, Viero, G, Itri, T, Ferroni, V, Pastore, V, Massafra, R, Liparoti, A, Muheberimana, T, Giommi, A, Bianco, R, De Azevedo, R, Chitani, G, Gualtierotti, R, Ferrari, B, Boasi, N, Pagliaro, E, Massimo, C, De Caro, M, Giachi, A, Montano, N, Vigone, B, Bellocchi, C, Carandina, A, Fiorelli, E, Melli, V, Tobaldini, E, Blasi, F, Aliberti, S, Spotti, M, Terranova, L, Misuraca, S, D'Adda, A, Fiore, S, Di Pasquale, M, Mantero, M, Contarini, M, Ori, M, Morlacchi, L, Rossetti, V, Gramegna, A, Pappalettera, M, Cavallini, M, Buscemi, A, Vicenzi, M, Rota, I, Costantino, G, Solbiati, M, Furlan, L, Mancarella, M, Colombo, G, Fanin, A, Passarella, M, Monzani, V, Canetta, C, Rovellini, A, Barbetta, L, Billi, F, Folli, C, Accordino, S, Maira, D, Hu, C, Motta, I, Scaramellini, N, Fracanzani, A, Lombardi, R, Cespiati, A, Cesari, M, Lucchi, T, Proietti, M, Calcaterra, L, Mandelli, C, Coppola, C, Cerizza, A, Pesenti, A, Grasselli, G, Galazzi, A, Monti, I, Galbussera, A, Crisafulli, E, Girelli, D, Maroccia, A, Gabbiani, D, Busti, F, Vianello, A, Biondan, M, Sartori, F, Faverio, P, Pesci, A, Zucchetti, S, Bonfanti, P, Rossi, M, Beretta, I, Spolti, A, Elia, D, Cassandro, R, Caminati, A, Cipollone, F, Guagnano, M, D'Ardes, D, Rossi, I, Vezzani, F, Spanevello, A, Cherubino, F, Visca, D, Contoli, M, Papi, A, Morandi, L, Battistini, N, Moreo, G, Iannuzzi, P, Fumagalli, D, Leone, S, Rossio R., Tettamanti M., Nobili A., Harari S., Mannucci P. M., Bandera A., Peyvandi F., Bosari S., Scudeller L., Fusetti G., Rusconi L., Dell'Orto S., Prati D., Valenti L., Giovannelli S., Manunta M., Lamorte G., Ferrari F., Gori A., Muscatello A., Mangioni D., Alagna L., Bozzi G., Lombardi A., Ungaro R., Ancona G., Zuglian G., Bolis M., Iannotti N., Ludovisi S., Comelli A., Renisi G., Biscarini S., Castelli V., Palomba E., Fava M., Fortina V., Peri C. A., Saltini P., Viero G., Itri T., Ferroni V., Pastore V., Massafra R., Liparoti A., Muheberimana T., Giommi A., Bianco R., De Azevedo R. M., Chitani G. E., Gualtierotti R., Ferrari B., Boasi N., Pagliaro E., Massimo C., De Caro M., Giachi A., Montano N., Vigone B., Bellocchi C., Carandina A., Fiorelli E., Melli V., Tobaldini E., Blasi F., Aliberti S., Spotti M., Terranova L., Misuraca S., D'Adda A., Fiore S. D., Di Pasquale M., Mantero M., Contarini M., Ori M., Morlacchi L., Rossetti V., Gramegna A., Pappalettera M., Cavallini M., Buscemi A., Vicenzi M., Rota I., Costantino G., Solbiati M., Furlan L., Mancarella M., Colombo G., Fanin A., Passarella M., Monzani V., Canetta C., Rovellini A., Barbetta L., Billi F., Folli C., Accordino S., Maira D., Hu C. M., Motta I., Scaramellini N., Fracanzani A. L., Lombardi R., Cespiati A., Cesari M., Lucchi T., Proietti M., Calcaterra L., Mandelli C., Coppola C., Cerizza A., Pesenti A. M., Grasselli G., Galazzi A., Monti I., Galbussera A. A., Crisafulli E., Girelli D., Maroccia A., Gabbiani D., Busti F., Vianello A., Biondan M., Sartori F., Faverio P., Pesci A., Zucchetti S., Bonfanti P., Rossi M., Beretta I., Spolti A., Elia D., Cassandro R., Caminati A., Cipollone F., Guagnano M. T., D'Ardes D., Rossi I., Vezzani F., Spanevello A., Cherubino F., Visca D., Contoli M., Papi A., Morandi L., Battistini N., Moreo G. L., Iannuzzi P., Fumagalli D., and Leone S.

Published
2022

32. Impact of the post‐COVID‐19 condition on health care after the first disease wave in Lombardy

Author

Pier M. Mannucci, Alessandro Nobili, Mauro Tettamanti, Barbara D'Avanzo, Alessia A. Galbussera, Giuseppe Remuzzi, Ida Fortino, Olivia Leoni, and Sergio Harari

Subjects
Intensive Care Units, SARS-CoV-2, Internal Medicine, COVID-19, Humans, Delivery of Health Care, Pandemics
Abstract

Lombardy was affected in the early months of 2020 by the SARS-CoV-2 pandemic with very high morbidity and mortality. The post-COVID-19 condition and related public health burden are scarcely known.Using the regional population administrative database including all the 48,932 individuals who survived COVID-19 and became polymerase-chain-reaction negative for SARS-CoV-2 by 31 May 2020, incident mortality, rehospitalizations, attendances to hospital emergency room, and outpatient medical visits were evaluated over a mid-term period of 6 months in 20,521 individuals managed at home, 26,016 hospitalized in medical wards, and 1611 in intensive care units (ICUs). These data were also evaluated in the corresponding period of 2019, when the region was not yet affected by the pandemic. Other indicators and proxies of the health-care burden related to the post-COVID condition were also evaluated.In individuals previously admitted to the ICU and medical wards, rehospitalizations, attendances to hospital emergency rooms, and out-patient medical visits were much more frequent in the 6-month period after SARS-CoV-2 negativization than in the same prepandemic period. Performances of spirometry increased more than 50-fold, chest CT scans 32-fold in ICU-admitted cases and 5.5-fold in non-ICU cases, and electrocardiography 5.6-fold in ICU cases and twofold in non-ICU cases. Use of drugs and biochemical tests increased in all cases.These results provide a real-life picture of the post-COVID condition and of its effects on the increased consumption of health-care resources, considered proxies of comorbidities.

Published
2022

33. Cognition, function, and prevalent dementia in centenarians and near‐centenarians: An individual participant data (IPD) meta‐analysis of 18 studies

Author

Leung, Yvonne, primary, Barzilai, Nir, additional, Batko‐Szwaczka, Agnieszka, additional, Beker, Nina, additional, Boerner, Kathrin, additional, Brayne, Carol, additional, Brodaty, Henry, additional, Cheung, Karen Siu‐Lan, additional, Corrada, María M., additional, Crawford, John D., additional, Galbussera, Alessia A., additional, Gondo, Yasuyuki, additional, Holstege, Henne, additional, Hulsman, Marc, additional, Ishioka, Yoshiko Lily, additional, Jopp, Daniela, additional, Kawas, Claudia H., additional, Kaye, Jeff, additional, Kochan, Nicole A., additional, Lau, Bobo Hi‐Po, additional, Lipnicki, Darren M., additional, Lo, Jessica W., additional, Lucca, Ugo, additional, Makkar, Steve R., additional, Marcon, Gabriella, additional, Martin, Peter, additional, Meguro, Kenichi, additional, Milman, Sofiya, additional, Poon, Leonard W., additional, Recchia, Angela, additional, Ribeiro, Oscar, additional, Riva, Emma, additional, Rott, Christoph, additional, Sikkes, Sietske AM, additional, Skoog, Ingmar, additional, Stephan, Blossom, additional, Szewieczek, Jan, additional, Teixeira, Laetitia, additional, Tettamanti, Mauro, additional, Wilczyński, Krzysztof, additional, and Sachdev, Perminder, additional

Published
2022
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34. Antihypertensive treatment changes and related clinical outcomes in older hospitalized patients

Author

Sebastiano, Cicco, D'Abbondanza, Marco, Proietti, Marco, Vincenzo, Zaccone, Chiara, Pes, Federica, Caradio, Mattioli, Massimo, Salvatore, Piano, Alberto Maria Marra, Alessandro, Nobili, Pier Mannuccio Mannucci, Antonello, Pietrangelo, Giorgio, Sesti, Elena, Buzzetti, Andrea, Salzano, Antonio, Cimellaro, Francesco, Perticone, Francesco, Violi, Gino Roberto Corazza, Salvatore, Corrao, Alessandra, Marengoni, Francesco, Salerno, Matteo, Cesari, Mauro, Tettamanti, Luca, Pasina, Carlotta, Franchi, Alessio, Novella, Gabriella, Miglio, Alessia Antonella Galbussera, Ilaria, Ardoino, Prisco, Domenico, Elena, Silvestri, Giacomo, Emmi, Alessandra, Bettiol, Irene, Mattioli, Gianni, Biolo, Michela, Zanetti, Giacomo, Bartelloni, Michele, Zaccari, Massimiliano, Chiuch, Massimo, Vanoli, Giulia, Grignani, Edoardo Alessandro Pulixi, Pirro, Matteo, Lupattelli, Graziana, Bianconi, Vanessa, Alcidi, Riccardo, Giotta, Alessia, Massimo, R Mannarino, Domenico, Girelli, Fabiana, Busti, Giacomo, Marchi, Mario, Barbagallo, Ligia, Dominguez, Vincenza, Beneduce, Federica, Cacioppo, Giuseppe, Natoli, Salvatore, Mularo, Massimo, Raspanti, Christiano, Argano, Federica, Cavallaro, Marco, Zoli, Maria Laura Matacena, Giuseppe, Orio, Eleonora, Magnolfi, Serafini, Giovanni, Angelo, Simili, Mattia, Brunori, Ilaria, Lazzari, Cappellini, MARIA DOMENICA, Giovanna, Fabio, Margherita Migone De Amicis, Giacomo De Luca, Natalia, Scaramellini, Valeria Di Stefano, Simona, Leoni, Sonia, Seghezzi, Alessandra Danuto Di Mauro, Diletta, Maira, Marta, Mancarella, Tiziano, Lucchi, Paolo Dionigi Rossi, Marta, Clerici, Alessandra Danuta Di Mauro, Giulia, Bonini, Conti, Federica, Silvia, Prolo, Maddalena, Fabrizi, Miriana, Martelengo, Giulia, Vigani, Antonio Di Sabatino, Emanuela, Miceli, Marco Vincenzo Lenti, Martina, Pisati, Lavinia, Pitotti, Donatella, Padula, Valentina, Antoci, Ginevra, Cambiè, Roberto, Pontremoli, Valentina, Beccati, Giulia, Nobili, Giovanna, Leoncini, Jacopo, Alberto, Federico, Cattaneo, Luigi, Anastasio, Lucia, Sofia, Carbone, LUIGI MARIA, Francesco, Cipollone, Maria Teresa Guagnano, Ilaria, Rossi, Emanuele, Valeriani, Damiani, D'Ardes, Lucia, Esposito, Simona, Sestili, Ermanno, Angelucci, Gerardo, Mancuso, Daniela, Calipari, Mosè, Bartone, Giuseppe, Delitala, Maria, Berria, Alessandro, Delitala, Maurizio, Muscaritoli, Alessio, Molfino, Enrico, Petrillo, Antonella, Giorgi, Christian, Gracin, Giovanni, Imbimbo, Giuseppe, Zuccalà, Gabriella, D'Aurizio, Giuseppe, Romanelli, Andrea, Volpini, Daniela, Lucente, Francesca, Manzoni, Annalisa, Pirozzi, Alberto, Zucchelli, Antonio, Picardi, Umberto Vespasiani Gentilucci, Paolo, Gallo, Chiara, Dell'Unto, Giuseppe, Bellelli, Maurizio, Corsi, Cesare, Antonucci, Chiara, Sidoli, Giulia, Principato, Alessandra, Bonfanti, Hajnalka, Szabo, Mazzola, Paolo, Piazzoli, Andrea, Franco, Arturi, Elena, Succurro, Bruno, Tassone, Federica, Giofrè, Maria Grazia Serra, Maria Antonietta Bleve, Antonio, Brucato, Teresa De Falco, Enrica, Negro, Martino, Brenna, Lucia, Trotta, Giovanni Lorenzo Squintani, Maria Luisa Randi, Fabrizio, Fabris, Irene, Bertozzi, Giulia, Bogoni, Maria Victoria Rabuini, Tancredi, Prandini, Francesco, Ratti, Chiara, Zurlo, Lorenzo, Cerruti, Elisabetta, Cosi, Roberto, Manfredini, Fabio, Fabbian, Benedetta, Boari, Alfredo De Giorgi, Ruana, Tiseo, Giuseppe, Paolisso, Maria Rosaria Rizzo, Claudia, Catalano, Irene Di Meo, Claudio, Borghi, Enrico, Strocchi, Eugenia, Ianniello, Mario, Soldati, Silvia, Schiavone, Alessio, Bragagni, Francesca Giulia Leoni, Valeria De Sando, Sara, Scarduelli, Michela, Cammarosano, Ilenia, Pareo, Carlo, Sabbà, Francesco Saverio Vella, Patrizia, Suppressa, Giovanni Michele De Vincenzo, Alessio, Comitangelo, Emanuele, Amoruso, Carlo, Custodero, Giuseppe, Re, Andrea, Schilardi, Francesca, Loparco, Luigi, Fenoglio, Andrea, Falcetta, Alessia Valentina Giraudo, Salvatore, D'Aniano, Anna, L Fracanzani, Silvia, Tiraboschi, Annalisa, Cespiati, Giovanna, Oberti, Giordano, Sigon, Felice, Cinque, Flora, Peyvandi, Raffaella, Rossio, Giulia, Colombo, Pasquale, Agosti, Erica, Pagliaro, Eleonora, Semproni, Canetta, Ciro, Valter, Monzani, Valeria, Savojardo, Giuliana, Ceriani, Christian, Folli, Giada, Pallini, Fabrizio, Montecucco, Luciano, Ottonello, Lara, Caserza, Giulia, Vischi, Salam, Kassem, Luca, Liberale, Nicola Lucio Liberato, Tiziana, Tognin, Francesco, Purrello, Antonino Di Pino, Salvatore, Piro, Renzo, Rozzini, Lina, Falanga, Maria Stella Pisciotta, Francesco Baffa Bellucci, Stefano, Buffelli, Camillo, Ferrandina, Francesca, Mazzeo, Elena, Spazzini, Giulia, Cono, Giulia, Cesaroni, Giuseppe, Montrucchio, Paolo, Peasso, Edoardo, Favale, Cesare, Poletto, Carl, Margaria, Maura, Sanino, Ludovica, Perri, Luigina, Guasti, Francesca, Rotunno, Luana, Castiglioni, Andrea, Maresca, Alessandro, Squizzato, Leonardo, Campiotti, Alessandra, Grossi, Roberto Davide Diprizio, Francesco, Dentali, Bertolotti, Marco, Chiara, Mussi, Giulia, Lancellotti, Maria Vittoria Libbra, Matteo, Galassi, Yasmine, Grassi, Alessio, Greco, Elena, Bigi, Pellegrini, Elisa, Laura, Orlandi, Giulia, Dondi, Lucia, Carulli, Angela, Sciacqua, Maria, Perticone, Rosa, Battaglia, Raffaele, Maio, Aleandra, Scozzafava, Valentino, Condoleo, Tania, Falbo, Lidia, Colangelo, Marco, Filice, Elvira, Clausi, Vincenzo, Stanghellini, Eugenio, Ruggeri, Sara Del Vecchio, Ilaria, Benzoni, Andrea, Salvi, Leonardi, Roberto, Giampaolo, Damiani, Gianluca, Moroncini, William, Capeci, Giuseppe Pio Martino, Biondi, Lorenzo, Pietro, Pettinari, Monica, Ormas, Emanuele, Filippini, Devis, Benfaremo, Roberto, Romiti, Riccardo, Ghio, Anna Dal Col, Salvatore, Minisola, Luciano, Colangelo, Mirella, Cilli, Giancarlo, Labbadia, Antonella, Afeltra, Benedetta, Marigliano, Maria Elena Pipita, Pietro, Castellino, Luca, Zanoli, Alfio, Gennaro, Agostino, Gaudio, Samuele, Pignataro, Francesca, Mete, Miriam, Gino, Guido, Moreo, Gloria, Pina, Alberto, Ballestrero, Fabio, Ferrando, Roberta, Gonella, Domenico, Cerminara, Paolo, Setti, Chiara, Traversa, Camilla, Scarsi, Bruno, Graziella, Stefano, Baldassarre, Salvatore, Fragapani, Gabriella, Gruden, Franco, Berti, Giuseppe, Famularo, Patrizia, Tarsitani, Roberto, Castello, Michela, Pasino, Marcello Giuseppe Maggio Gian Paolo Ceda, Simonetta, Morganti, Andrea, Artoni, Margherita, Grossi, Stefano Del Giacco, Davide, Firinu, Giulia, Costanzo, Giacomo, Argiolas, Giovanni, Paoletti, Francesca, Losa, Montalto, GIUSEPPE ALBERT, Anna, Licata, Filippo Alessandro Montalto, Francesco, Corica, Giorgio, Basile, Antonino, Catalano, Federica, Bellone, Concetto, Principato, Lorenzo, Malatino, Benedetta, Stancanelli, Valentina, Terranova, Salvatore Di Marca, Rosario Di Quattro, Lara La Malfa, Rossella, Caruso, Mecocci, Patrizia, Ruggiero, Carmelinda, Boccardi, Virginia, Tiziana, Meschi, Andrea, Ticinesi, Antonio, Nouvenne, Pietro, Minuz, Luigi, Fondrieschi, Giandomenico Nigro Imperiale, Sarah, Morellini, Mario, Pirisi, Gian Paolo Fra, Daniele, Sola, Mattia, Bellan, Roberto, Quadri, Erica, Larovere, Marco, Novelli, Emilio, Simeone, Rosa, Scurti, Fabio, Tolloso, Tarquini, Roberto, Alice, Valoriani, Silvia, Dolenti, Giulia, Vannini, Volpi, Riccardo, Pietro, Bocchi, Alessandro, Vignali, Sergio, Harari, Chiara, Lonati, Federico, Napoli, Italia, Aiello, Teresa, Salvatore, Lucio, Monaco, Carmen, Ricozzi, Alberto, Pilotto, Ilaria, Indiano, Federica, Gandolfo, Franco Laghi Pasini, Pier Leopoldo Capecchi, Ranuccio, Nuti, Roberto, Valenti, Martina, Ruvio, Silvia, Cappelli, Alberto, Palazzuoli, Mauro, Bernardi, Silvia Li Bassi, Luca, Santi, Giacomo, Zaccherini, Vittorio, Durante, Daniela, Tirotta, Giovanna, Eusebi, Cattaneo, Marco Natale, Amoruso, MARIA VALENTINA, Paola, Fracasso, Cristina, Fasolino, Moreno, Tresoldi, Enrica, Bozzolo, Sarah, Damanti, Massimo, Porta, Giuseppe, Armentaro, Maria Immacolata Arnone, Milena, Barone, Lorenzo, Bertolino, Sara, Bianco, Nicolò, Binello, Simona, Brancati, Agostino, Buonauro, William, Cordeddu, Curcio, Rosa, Andrea, Dalbeni, Salvatore, D'Agnano, Damiano, D'Ardes, Martina De Feo, Emilia, Donnarumma, Marco, Fei, Carmine Gabriele Gambino, Paolo, Giorgini, Lombardi, Rosa, Giuseppe, Miceli, Paola, Naccarato, Silvia, Noviello, Gaia, Olivieri, Roberta, Parente, Francesca Serena Pignataro, Sonia, Poma, Enrica, Porceddu, Pucci, Giacomo, Marco, Ricchio, Anna, Sabena, Marco, Salice, Claudia, Santarossa, Ambra, Savona, Caterina, Savrié, Roberto, Scicali, Mario, Stabile, Giovanni, Talerico, Michela, Talia, Eliezer Joseph Tassone, Thomas, Teatini, Elisabetta, Tombolini, Matteo, Traversa, Elia, Vettore, Alessandro, Vignal, Luca, Vilardi, Rosanna, Villani, Francesco, Vitale, Cicco, Sebastiano, D Abbondanza, Marco, Proietti, Marco, Zaccone, Vincenzo, Pes, Chiara, Caradio, Federica, Mattioli, Massimo, Piano, Salvatore, Marra, Alberto Maria, Nobili, Alessandro, Mannucci, Pier Mannuccio, Pietrangelo, Antonello, Sesti, Giorgio, Buzzetti, Elena, Salzano, Andrea, Cimellaro, Antonio, Antonio Cimellaro, Salvatore, Corrao, Mario, Barbagallo, Anna, Licata, Giuseppe, Montalto, Paolisso, Giuseppe, Rizzo, Maria Rosaria, and Cimellaro, Antonio - Giovani Internisti Società Italiana di Medicina Interna (GIS-SIMI) and of the REPOSI Investigators

Subjects
cardiovascular events, older patient, hypertension, antihypertensive drugs, older patients, survival, Clinical Biochemistry, antihypertensive drug, General Medicine, Biochemistry, cardiovascular event
Abstract

Background: Hypertension management in older patients represents a challenge, particularly when hospitalized. Objective: The objective of this study is to investigate the determinants and related outcomes of antihypertensive drug prescription in a cohort of older hospitalized patients. Methods: A total of 5671 patients from REPOSI (a prospective multicentre observational register of older Italian in-patients from internal medicine or geriatric wards) were considered; 4377 (77.2%) were hypertensive. Minimum treatment (MT) for hypertension was defined according to the 2018 ESC guidelines [an angiotensin-converting-enzyme-inhibitor (ACE-I) or an angiotensin-receptor-blocker (ARB) with a calcium-channel-blocker (CCB) and/or a thiazide diuretic; if >80 years old, an ACE-I or ARB or CCB or thiazide diuretic]. Determinants of MT discontinuation at discharge were assessed. Study outcomes were any cause rehospitalization/all cause death, all-cause death, cardiovascular (CV) hospitalization/death, CV death, non-CV death, evaluated according to the presence of MT at discharge. Results: Hypertensive patients were older than normotensives, with a more impaired functional status, higher burden of comorbidity and polypharmacy. A total of 2233 patients were on MT at admission, 1766 were on MT at discharge. Discontinuation of MT was associated with the presence of comorbidities (lower odds for diabetes, higher odds for chronic kidney disease and dementia). An adjusted multivariable logistic regression analysis showed that MT for hypertension at discharge was associated with lower risk of all-cause death, all-cause death/hospitalization, CV death, CV death/hospitalization and non-CV death. Conclusions: Guidelines-suggested MT for hypertension at discharge is associated with a lower risk of adverse clinical outcomes. Nevertheless, changes in antihypertensive treatment still occur in a significant proportion of older hospitalized patients.

Published
2023

35. Clinical features and outcomes of elderly hospitalised patients with chronic obstructive pulmonary disease, heart failure or both

Author

Crisafulli, Ernesto, Sartori, Giulia, Vianello, Alice, Busti, Fabiana, Nobili, Alessandro, Mannucci, Pier Mannuccio, Girelli, Domenico, Sesti, Giorgio, Pietrangelo, Antonello, Perticone, Francesco, Violi, Francesco, Corrao, Salvatore, Marengoni, Alessandra, Tettamanti, Mauro, Pasina, Luca, Franchi, Carlotta, Novella, Alessio, Miglio, Gabriella, Galbussera, Alessia Antonella, Ardoino, Ilaria, Prisco, Domenico, Silvestri, Elena, Emmi, Giacomo, Bettiol, Alessandra, Mattioli, Irene, Biolo, Gianni, Zanetti, Michela, Bartelloni, Giacomo, Zaccari, Michele, Chiuch, Massimiliano, Vanoli, Massimo, Grignani, Giulia, Pulixi, Edoardo Alessandro, Pirro, Matteo, Lupattelli, Graziana, Bianconi, Vanessa, Alcidi, Riccardo, Giotta, Alessia, Mannarino, Massimo R, Marchi, Giacomo, Barbagallo, Mario, Dominguez, Ligia, Beneduce, Vincenza, Cacioppo, Federica, Trotta, Lucia, Squintani, Giovanni L, Randi, Maria Luigia, Fabris, Fabrizio, Bertozzi, Irene, Bogoni, Giulia, Rabuini, Maria Victoria, Prandini, Tancredi, Ratti, Francesco, Zurlo, Chiara, Cerruti, Lorenzo, Cosi, Elisabetta, and Et, Al.

Subjects
Hospital cure, Chronic obstructive pulmonary disease, Heart failure, Mortality, Multimorbidity, Prognosis
Published
2023

36. MGUS and clonal hematopoiesis show unrelated clinical and biological trajectories in an older population cohort

Author

Da Vià, Matteo Claudio, primary, Lionetti, Marta, additional, Marella, Alessio, additional, Matera, Antonio, additional, Travaglino, Erica, additional, Signaroldi, Elena, additional, Galbussera, Alessia Antonella, additional, Lucca, Ugo, additional, Mandelli, Sara, additional, Riva, Emma, additional, Tettamanti, Mauro, additional, Pettine, Loredana, additional, Pompa, Alessandra, additional, Baldini, Luca, additional, Neri, Antonino, additional, Della Porta, Matteo Giovanni, additional, and Bolli, Niccolò, additional

Published
2022
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37. Willingness to share contacts in case of COVID-19 positivity–predictors of collaboration resistance in a nation-wide Italian survey

Author

Bikbov, Boris, primary, Tettamanti, Mauro, additional, Bikbov, Alexander, additional, D’Avanzo, Barbara, additional, Galbussera, Alessia Antonella, additional, Nobili, Alessandro, additional, Calamandrei, Gemma, additional, Candini, Valentina, additional, Starace, Fabrizio, additional, Zarbo, Cristina, additional, and de Girolamo, Giovanni, additional

Published
2022
Full Text
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38. Clinical factors associated with death in 3044 COVID-19 patients managed in internal medicine wards in Italy: comment

Author

Bandera, A., Nobili, A., Tettamanti, M., Harari, S., Bosari, S., Mannucci, P. M., Scudeller, L., Fusetti, G., Rusconi, L., Dell'Orto, S., Prati, D., Valenti, L., Giovannelli, S., Manunta, M., Lamorte, G., Ferrari, F., Gori, A., Muscatello, A., Mangioni, D., Alagna, L., Bozzi, G., Lombardi, A., Ungaro, R., Ancona, G., Zuglian, G., Bolis, M., Iannotti, N., Ludovisi, S., Comelli, A., Renisi, G., Biscarini, S., Castelli, V., Palomba, E., Fava, M., Fortina, V., Peri, C. A., Saltini, P., Viero, G., Itri, T., Ferroni, V., Pastore, V., Massafra, R., Liparoti, A., Muheberimana, T., Giommi, A., Bianco, R., De Azevedo, R. M., Chitani, G. E., Peyvandi, F., Gualtierotti, R., Ferrari, B., Rossio, R., Boasi, N., Pagliaro, E., Massimo, C., De Caro, M., Montano, N., Vigone, B., Bellocchi, C., Carandina, A., Fiorelli, E., Melli, V., Tobaldini, E., Blasi, F., Aliberti, S., Spotti, M., Terranova, L., Misuraca, S., D'Adda, A., Della Fiore, S., Di Pasquale, M., Contarini, M. M. M., Ori, M., Morlacchi, L., Rossetti, V., Gramegna, A., Pappalettera, M., Cavallini, M., Buscemi, A., Vicenzi, M., Rota, I., Costantino, G., Solbiati, M., Furlan, L., Mancarella, M., Colombo, G., Fanin, A., Passarella, M., Monzani, V., Canetta, C., Rovellini, A., Barbetta, L., Billi, F., Folli, C., Accordino, S., Maira, D., C. M., Hu, Motta, I., Scaramellini, N., Fracanzani, A. L., Lombardi, R., Cespiati, A., Cesari, M., Lucchi, T., Proietti, M., Calcaterra, L., Mandelli, C., Coppola, C., Cerizza, A., Pesenti, A. M., Grasselli, G., Galazzi, A., Monti, I., Galbussera, A. A., Crisafulli, E., Girelli, D., Maroccia, A., Gabbiani, D., Busti, F., Vianello, A., Biondan, M., Sartori, F., Faverio, P., Pesci, A., Zucchetti, S., Bonfanti, P., Rossi, M., Beretta, I., Spolti, A., Elia, D., Cassandro, R., Caminati, A., Cipollone, F., Guagnano, M. T., D'Ardes, D., Rossi, I., Vezzani, F., Spanevello, A., Cherubino, F., Visca, D., Contoli, M., Papi, A., Morandi, L., Battistini, N., Moreo, G. L., Iannuzzi, P., Fumagalli, D., Leone, S., Bandera, A, Nobili, A, Tettamanti, M, Harari, S, Bosari, S, Mannucci, P, Scudeller, L, Fusetti, G, Rusconi, L, Dell'Orto, S, Prati, D, Valenti, L, Giovannelli, S, Manunta, M, Lamorte, G, Ferrari, F, Gori, A, Muscatello, A, Mangioni, D, Alagna, L, Bozzi, G, Lombardi, A, Ungaro, R, Ancona, G, Zuglian, G, Bolis, M, Iannotti, N, Ludovisi, S, Comelli, A, Renisi, G, Biscarini, S, Castelli, V, Palomba, E, Fava, M, Fortina, V, Peri, C, Saltini, P, Viero, G, Itri, T, Ferroni, V, Pastore, V, Massafra, R, Liparoti, A, Muheberimana, T, Giommi, A, Bianco, R, De Azevedo, R, Chitani, G, Peyvandi, F, Gualtierotti, R, Ferrari, B, Rossio, R, Boasi, N, Pagliaro, E, Massimo, C, De Caro, M, Montano, N, Vigone, B, Bellocchi, C, Carandina, A, Fiorelli, E, Melli, V, Tobaldini, E, Blasi, F, Aliberti, S, Spotti, M, Terranova, L, Misuraca, S, D'Adda, A, Della Fiore, S, Di Pasquale, M, Contarini, M, Ori, M, Morlacchi, L, Rossetti, V, Gramegna, A, Pappalettera, M, Cavallini, M, Buscemi, A, Vicenzi, M, Rota, I, Costantino, G, Solbiati, M, Furlan, L, Mancarella, M, Colombo, G, Fanin, A, Passarella, M, Monzani, V, Canetta, C, Rovellini, A, Barbetta, L, Billi, F, Folli, C, Accordino, S, Maira, D, Hu, C, Motta, I, Scaramellini, N, Fracanzani, A, Lombardi, R, Cespiati, A, Cesari, M, Lucchi, T, Proietti, M, Calcaterra, L, Mandelli, C, Coppola, C, Cerizza, A, Pesenti, A, Grasselli, G, Galazzi, A, Monti, I, Galbussera, A, Crisafulli, E, Girelli, D, Maroccia, A, Gabbiani, D, Busti, F, Vianello, A, Biondan, M, Sartori, F, Faverio, P, Pesci, A, Zucchetti, S, Bonfanti, P, Rossi, M, Beretta, I, Spolti, A, Elia, D, Cassandro, R, Caminati, A, Cipollone, F, Guagnano, M, D'Ardes, D, Rossi, I, Vezzani, F, Spanevello, A, Cherubino, F, Visca, D, Contoli, M, Papi, A, Morandi, L, Battistini, N, Moreo, G, Iannuzzi, P, Fumagalli, D, and Leone, S

Subjects
Adult, medicine.medical_specialty, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Critical Care, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Ce - Letter to the Editor, MEDLINE, Cohort Studies, Hospital, Internal Medicine, Medicine, Humans, Hospital Mortality, Intensive care medicine, Aged, Aged, 80 and over, business.industry, SARS-CoV-2, COVID-19, Middle Aged, Respiration, Artificial, Hospitals, Hospitalization, Survival Rate, Italy, Emergency Medicine, business, Human
Abstract

During the COVID-19 2020 outbreak, a large body of data has been provided on general management and outcomes of hospitalized COVID-19 patients. Yet, relatively little is known on characteristics and outcome of patients managed in Internal Medicine Units (IMU). To address this gap, the Italian Society of Internal Medicine has conducted a nationwide cohort multicentre study on death outcome in adult COVID-19 patients admitted and managed in IMU. This study assessed 3044 COVID-19 patients at 41 referral hospitals across Italy from February 3rd to May 8th 2020. Demographics, comorbidities, organ dysfunction, treatment, and outcomes including death were assessed. During the study period, 697 patients (22.9%) were transferred to intensive care units, and 351 died in IMU (death rate 14.9%). At admission, factors independently associated with in-hospital mortality were age (OR 2.46, p = 0.000), productive cough (OR 2.04, p = 0.000), pre-existing chronic heart failure (OR 1.58, p = 0.017) and chronic obstructive pulmonary disease (OR 1.17, p = 0.048), the number of comorbidities (OR 1.34, p = 0.000) and polypharmacy (OR 1.20, p = 0.000). Of note, up to 40% of elderly patients did not report fever at admission. Decreasing PaO

Published
2022

39. Clinical relevance of clonal hematopoiesis in persons aged ≥80 years

Author

Rossi, M, Meggendorfer, M, Zampini, M, Tettamanti, M, Riva, E, Travaglino, E, Bersanelli, M, Mandelli, S, Galbussera, A, Mosca, E, Saba, E, Chiereghin, C, Manes, N, Milanesi, C, Ubezio, M, Morabito, L, Peano, C, Soldà, G, Asselta, R, Duga, S, Selmi, C, De Santis, M, Malik, K, Maggioni, G, Bicchieri, M, Campagna, A, Tentori, C, Russo, A, Civilini, E, Allavena, P, Piazza, R, Corrao, G, Sala, C, Termanini, A, Giordano, L, Detoma, P, Malabaila, A, Sala, L, Rosso, S, Zanetti, R, Saitta, C, Condorelli, G, Passamonti, F, Santoro, A, Sole, F, Platzbecker, U, Fenaux, P, Bolli, N, Castellani, G, Kern, W, Vassiliou, G, Haferlach, T, Lucca, U, Della Porta, M, Rossi, Marianna, Meggendorfer, Manja, Zampini, Matteo, Tettamanti, Mauro, Riva, Emma, Travaglino, Erica, Bersanelli, Matteo, Mandelli, Sara, Galbussera, Alessia Antonella, Mosca, Ettore, Saba, Elena, Chiereghin, Chiara, Manes, Nicla, Milanesi, Chiara, Ubezio, Marta, Morabito, Lucio, Peano, Clelia, Soldà, Giulia, Asselta, Rosanna, Duga, Stefano, Selmi, Carlo, De Santis, Maria, Malik, Karolina, Maggioni, Giulia, Bicchieri, Maria Elena, Campagna, Alessia, Tentori, Cristina Astrid, Russo, Antonio, Civilini, Efrem, Allavena, Paola, Piazza, Rocco, Corrao, Giovanni, Sala, Claudia, Termanini, Alberto, Giordano, Laura, Detoma, Paolo, Malabaila, Aurelio, Sala, Luca, Rosso, Stefano, Zanetti, Roberto, Saitta, Claudia, Riva, Elena, Condorelli, Gianluigi, Passamonti, Francesco, Santoro, Armando, Sole, Francesc, Platzbecker, Uwe, Fenaux, Pierre, Bolli, Niccolo, Castellani, Gastone, Kern, Wolfgang, Vassiliou, George, Haferlach, Torsten, Lucca, Ugo, Della Porta, Matteo G, Rossi, M, Meggendorfer, M, Zampini, M, Tettamanti, M, Riva, E, Travaglino, E, Bersanelli, M, Mandelli, S, Galbussera, A, Mosca, E, Saba, E, Chiereghin, C, Manes, N, Milanesi, C, Ubezio, M, Morabito, L, Peano, C, Soldà, G, Asselta, R, Duga, S, Selmi, C, De Santis, M, Malik, K, Maggioni, G, Bicchieri, M, Campagna, A, Tentori, C, Russo, A, Civilini, E, Allavena, P, Piazza, R, Corrao, G, Sala, C, Termanini, A, Giordano, L, Detoma, P, Malabaila, A, Sala, L, Rosso, S, Zanetti, R, Saitta, C, Condorelli, G, Passamonti, F, Santoro, A, Sole, F, Platzbecker, U, Fenaux, P, Bolli, N, Castellani, G, Kern, W, Vassiliou, G, Haferlach, T, Lucca, U, Della Porta, M, Rossi, Marianna, Meggendorfer, Manja, Zampini, Matteo, Tettamanti, Mauro, Riva, Emma, Travaglino, Erica, Bersanelli, Matteo, Mandelli, Sara, Galbussera, Alessia Antonella, Mosca, Ettore, Saba, Elena, Chiereghin, Chiara, Manes, Nicla, Milanesi, Chiara, Ubezio, Marta, Morabito, Lucio, Peano, Clelia, Soldà, Giulia, Asselta, Rosanna, Duga, Stefano, Selmi, Carlo, De Santis, Maria, Malik, Karolina, Maggioni, Giulia, Bicchieri, Maria Elena, Campagna, Alessia, Tentori, Cristina Astrid, Russo, Antonio, Civilini, Efrem, Allavena, Paola, Piazza, Rocco, Corrao, Giovanni, Sala, Claudia, Termanini, Alberto, Giordano, Laura, Detoma, Paolo, Malabaila, Aurelio, Sala, Luca, Rosso, Stefano, Zanetti, Roberto, Saitta, Claudia, Riva, Elena, Condorelli, Gianluigi, Passamonti, Francesco, Santoro, Armando, Sole, Francesc, Platzbecker, Uwe, Fenaux, Pierre, Bolli, Niccolo, Castellani, Gastone, Kern, Wolfgang, Vassiliou, George, Haferlach, Torsten, Lucca, Ugo, and Della Porta, Matteo G

Abstract

Clonal hematopoiesis of indeterminate potential (CHIP) is associated with increased risk of cancers and inflammation-related diseases. This phenomenon becomes common in persons aged ≥80 years, in whom the implications of CHIP are not well defined. We performed a mutational screening in 1794 persons aged ≥80 years and investigated the relationships between CHIP and associated pathologies. Mutations were observed in one-third of persons aged ≥80 years and were associated with reduced survival. Mutations in JAK2 and splicing genes, multiple mutations (DNMT3A, TET2, and ASXL1 with additional genetic lesions), and variant allele frequency ≥0.096 had positive predictive value for myeloid neoplasms. Combining mutation profiles with abnormalities in red blood cell indices improved the ability of myeloid neoplasm prediction. On this basis, we defined a predictive model that identifies 3 risk groups with different probabilities of developing myeloid neoplasms. Mutations in DNMT3A, TET2, ASXL1, or JAK2 were associated with coronary heart disease and rheumatoid arthritis. Cytopenia was common in persons aged ≥80 years, with the underlying cause remaining unexplained in 30% of cases. Among individuals with unexplained cytopenia, the presence of highly specific mutation patterns was associated with myelodysplastic-like phenotype and a probability of survival comparable to that of myeloid neoplasms. Accordingly, 7.5% of subjects aged ≥80 years with cytopenia had presumptive evidence of myeloid neoplasm. In summary, specific mutational patterns define different risk of developing myeloid neoplasms vs inflammatory-associated diseases in persons aged ≥80 years. In individuals with unexplained cytopenia, mutational status may identify those subjects with presumptive evidence of myeloid neoplasms.

Published
2021

40. The role of diet on the risk of dementia in the oldest old: The Monzino 80-plus population-based study

Author

Sara Mandelli, Alessia A. Galbussera, Emma Riva, Patrizia Riso, Ugo Lucca, Carlotta Franchi, Cristina Nicoli, Mauro Tettamanti, Cristina Bosetti, Pierluigi Quadri, Silvano Gallus, and Gabriella Marcon

Subjects
Male, Longitudinal study, Mediterranean diet, Population, Diet, Mediterranean, Critical Care and Intensive Care Medicine, Diet Surveys, Nutrition Policy, Nutrient density, Risk Factors, Prevalence, Humans, Medicine, Dementia, Longitudinal Studies, education, Aged, 80 and over, education.field_of_study, Nutrition and Dietetics, business.industry, Incidence, Incidence (epidemiology), Hazard ratio, Dementia Very old people Population-based study Risk factors Foods Mediterranean diet, medicine.disease, Confidence interval, Diet, Cross-Sectional Studies, Italy, Female, Guideline Adherence, business, Demography
Abstract

Summary Background & aims Longevity also carries its dark side of age-related chronic diseases, dementia being one of the worst and the most prevalent. Since dementia lacks effective treatments, preventing or delaying it is highly desirable. Dietary habits and nutrition have been found to be important modifiable risk factors for many chronic diseases, but evidence on the role of diet on the risk of dementia is still limited, particularly among the very old. Aim of the present work is to study the association of the Mediterranean diet and its components with prevalent and incident dementia in the oldest-old. Methods We analyzed data from the Monzino 80-plus study, a population-based study in subjects 80 years or older in the Varese province, Italy. A validated food frequency questionnaire was used to collect information on 23 different foods consumed in the previous year. A Mediterranean diet score was calculated and its components were classified into tertiles. Multivariable models for dementia prevalence and incidence were adjusted for demographic and clinical characteristics. Results Information on nutrition was available for 1390 subjects in the cross-sectional study and 512 subjects in the longitudinal study, mean respective ages 93 and 92. Greater adherence to Mediterranean diet, greater consumption of eggs, fruits and vegetables, carbohydrates, and greater food intake were associated with a lower prevalence of dementia. Increasing number of portions per week and consumption of legumes significantly decreased the incidence of dementia during the 3.6 year mean follow-up: corresponding hazard ratios of highest vs. lowest tertiles (95% confidence intervals) were 0.66 (0.46–0.95) and 0.68 (0.47–0.97), respectively. Conclusion Oldest-old eating less and having diets with less variety and nutrient density were more frequent among subjects with dementia. The longitudinal analysis confirmed oldest-old subjects who eat more portions, as well as those who have a higher intake of legumes, are at decreased risk of developing dementia even though reverse causality cannot be completely ruled out.

Published
2021

42. Clinical relevance of clonal hematopoiesis in persons aged ≥80 years

Author

Aurelio Malabaila, Maria De Santis, Paolo Detoma, Erica Travaglino, Alessia A. Galbussera, Elena Saba, Emma Riva, Rocco Piazza, Marta Ubezio, Maria Elena Bicchieri, Armando Santoro, Gianluigi Condorelli, Matteo Bersanelli, Sara Mandelli, Chiara Chiereghin, George S. Vassiliou, Stefano Duga, Paola Allavena, Francesco Passamonti, Efrem Civilini, Claudia Sala, Matteo Zampini, Luca Sala, Giovanni Corrao, Francesc Solé, Uwe Platzbecker, Karolina Malik, Ettore Mosca, N. Manes, Matteo G. Della Porta, Ugo Lucca, Alessia Campagna, Claudia Saitta, Mauro Tettamanti, Torsten Haferlach, Gastone Castellani, Wolfgang Kern, Laura Giordano, Clelia Peano, Giulia Soldà, Cristina Astrid Tentori, Giulia Maggioni, Stefano Rosso, Manja Meggendorfer, Roberto Zanetti, Chiara Milanesi, Elena Riva, Rosanna Asselta, Pierre Fenaux, Alberto Termanini, Marianna Rossi, Niccolo Bolli, Carlo Selmi, Lucio Morabito, Antonio Russo, Rossi M., Meggendorfer M., Zampini M., Tettamanti M., Riva E., Travaglino E., Bersanelli M., Mandelli S., Antonella Galbussera A., Mosca E., Saba E., Chiereghin C., Manes N., Milanesi C., Ubezio M., Morabito L., Peano C., Solda G., Asselta R., Duga S., Selmi C., De Santis M., Malik K., Maggioni G., Bicchieri M., Campagna A., Tentori C.A., Russo A., Civilini E., Allavena P., Piazza R., Corrao G., Sala C., Termanini A., Giordano L., Detoma P., Malabaila A., Sala L., Rosso S., Zanetti R., Saitta C., Condorelli G., Passamonti F., Santoro A., Sole F., Platzbecker U., Fenaux P., Bolli N., Castellani G., Kern W., Vassiliou G.S., Haferlach T., Lucca U., Della Porta M.G., Rossi, M, Meggendorfer, M, Zampini, M, Tettamanti, M, Riva, E, Travaglino, E, Bersanelli, M, Mandelli, S, Galbussera, A, Mosca, E, Saba, E, Chiereghin, C, Manes, N, Milanesi, C, Ubezio, M, Morabito, L, Peano, C, Soldà, G, Asselta, R, Duga, S, Selmi, C, De Santis, M, Malik, K, Maggioni, G, Bicchieri, M, Campagna, A, Tentori, C, Russo, A, Civilini, E, Allavena, P, Piazza, R, Corrao, G, Sala, C, Termanini, A, Giordano, L, Detoma, P, Malabaila, A, Sala, L, Rosso, S, Zanetti, R, Saitta, C, Condorelli, G, Passamonti, F, Santoro, A, Sole, F, Platzbecker, U, Fenaux, P, Bolli, N, Castellani, G, Kern, W, Vassiliou, G, Haferlach, T, Lucca, U, and Della Porta, M

Subjects
Oncology, Male, Myeloid, Coronary Disease, Biochemistry, Arthritis, Rheumatoid, hemic and lymphatic diseases, aged adult, 80 and over, follow-up, cytopenia, Age Factor, Aged, 80 and over, Myeloid Neoplasia, medicine.diagnostic_test, Age Factors, leukemia, vascular disease, Hematology, anemia, myeloid neoplasms, Leukemia, Haematopoiesis, medicine.anatomical_structure, Leukemia, Myeloid, hematopoiesi, Female, Human, medicine.medical_specialty, Anemia, Immunology, Myelodysplastic Syndrome, Myeloid Neoplasm, Internal medicine, medicine, clonal hematopoiesis, Humans, mean corpuscular volume analyse, Clinical significance, coronary heart disease, Red blood cell indices, Cytopenia, business.industry, mutational screening, Cell Biology, medicine.disease, Myelodysplastic Syndromes, Mutation, Clonal Hematopoiesi, business, hematologic neoplasm
Abstract

Clonal hematopoiesis of indeterminate potential (CHIP) is associated with increased risk of cancers and inflammation-related diseases. This phenomenon becomes common in persons aged ≥80 years, in whom the implications of CHIP are not well defined. We performed a mutational screening in 1794 persons aged ≥80 years and investigated the relationships between CHIP and associated pathologies. Mutations were observed in one-third of persons aged ≥80 years and were associated with reduced survival. Mutations in JAK2 and splicing genes, multiple mutations (DNMT3A, TET2, and ASXL1 with additional genetic lesions), and variant allele frequency ≥0.096 had positive predictive value for myeloid neoplasms. Combining mutation profiles with abnormalities in red blood cell indices improved the ability of myeloid neoplasm prediction. On this basis, we defined a predictive model that identifies 3 risk groups with different probabilities of developing myeloid neoplasms. Mutations in DNMT3A, TET2, ASXL1, or JAK2 were associated with coronary heart disease and rheumatoid arthritis. Cytopenia was common in persons aged ≥80 years, with the underlying cause remaining unexplained in 30% of cases. Among individuals with unexplained cytopenia, the presence of highly specific mutation patterns was associated with myelodysplastic-like phenotype and a probability of survival comparable to that of myeloid neoplasms. Accordingly, 7.5% of subjects aged ≥80 years with cytopenia had presumptive evidence of myeloid neoplasm. In summary, specific mutational patterns define different risk of developing myeloid neoplasms vs inflammatory-associated diseases in persons aged ≥80 years. In individuals with unexplained cytopenia, mutational status may identify those subjects with presumptive evidence of myeloid neoplasms.

Published
2021

44. Cognition, function, and prevalent dementia in centenarians and near-centenarians: An individual participant data (IPD) meta-analysis of 18 studies

Author

Yvonne Leung, Nir Barzilai, Agnieszka Batko‐Szwaczka, Nina Beker, Kathrin Boerner, Carol Brayne, Henry Brodaty, Karen Siu‐Lan Cheung, María M. Corrada, John D. Crawford, Alessia A. Galbussera, Yasuyuki Gondo, Henne Holstege, Marc Hulsman, Yoshiko Lily Ishioka, Daniela Jopp, Claudia H. Kawas, Jeff Kaye, Nicole A. Kochan, Bobo Hi‐Po Lau, Darren M. Lipnicki, Jessica W. Lo, Ugo Lucca, Steve R. Makkar, Gabriella Marcon, Peter Martin, Kenichi Meguro, Sofiya Milman, Leonard W. Poon, Angela Recchia, Oscar Ribeiro, Emma Riva, Christoph Rott, Sietske AM Sikkes, Ingmar Skoog, Blossom Stephan, Jan Szewieczek, Laetitia Teixeira, Mauro Tettamanti, Krzysztof Wilczyński, Perminder Sachdev, Amsterdam Neuroscience - Neurodegeneration, VU University medical center, Neurology, Sachdev, Perminder [0000-0002-9595-3220], and Apollo - University of Cambridge Repository

Subjects
Male, Aged, 80 and over, education, Epidemiology, Health Policy, prevalence, exceptional longevity, Body Mass Index, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Cognition, Developmental Neuroscience, centenarians, dementia, education, exceptional longevity, prevalence, risk factors, Humans, Educational Status, risk factors, Female, Neurology (clinical), centenarians, Geriatrics and Gerontology, dementia
Abstract

Introduction: There are limited data on prevalence of dementia in centenarians and near-centenarians (C/NC), its determinants, and whether the risk of dementia continues to rise beyond 100. Methods: Participant-level data were obtained from 18 community-based studies (N = 4427) in 11 countries that included individuals ≥95 years. A harmonization protocol was applied to cognitive and functional impairments, and a meta-analysis was performed. Results: The mean age was 98.3 years (SD = 2.67); 79% were women. After adjusting for age, sex, and education, dementia prevalence was 53.2% in women and 45.5% in men, with risk continuing to increase with age. Education (OR 0.95;0.92–0.98) was protective, as was hypertension (odds ratio [OR] 0.51;0.35–0.74) in five studies. Dementia was not associated with diabetes, vision and hearing impairments, smoking, and body mass index (BMI). Discussion: Among the exceptional old, dementia prevalence remains higher in the older participants. Education was protective against dementia, but other factors for dementia-free survival in C/NC remain to be understood.

Published
2022

45. MGUS and clonal hematopoiesis show unrelated clinical and biological trajectories in an older population cohort

Author

Matteo Claudio Da Vià, Marta Lionetti, Alessio Marella, Antonio Matera, Erica Travaglino, Elena Signaroldi, Alessia Antonella Galbussera, Ugo Lucca, Sara Mandelli, Emma Riva, Mauro Tettamanti, Loredana Pettine, Alessandra Pompa, Luca Baldini, Antonino Neri, Matteo Giovanni Della Porta, and Niccolò Bolli

Subjects
Aged, 80 and over, Cohort Studies, immune system diseases, hemic and lymphatic diseases, Paraproteinemias, Humans, Hematology, Clonal Hematopoiesis, Multiple Myeloma, Monoclonal Gammopathy of Undetermined Significance, Aged
Abstract

Monoclonal gammopathy of undetermined significance (MGUS) and clonal hematopoiesis (CH) are 2 preclinical clonal expansions of hematopoietic cells whose prevalence rises with age, reaching almost 10% in people of aged 70 years and older. The increased risk of myeloid malignancies in patients with myeloma is well defined, and the study of the association between CH and MGUS could help explain this phenomenon. Here, we analyzed a fully clinically annotated dataset of 777 older subjects (median age, 91 years) previously screened for prevalence of CH. The prevalence of MGUS and CH was 9.6% and 17.3%, respectively. We detected CH in 9.7% of the patients with MGUS and MGUS in 5.5% of the patients with CH. We did not find a significant correlation between the presence of MGUS and CH. Furthermore, the 2 conditions showed a differential association with clinical and laboratory covariates, suggesting that MGUS and CH may represent age-associated unrelated clonal drifts of hematopoietic cells. Confirmatory studies are needed to assess the relevance of CH in plasma cell disorders. This trial was registered at www.clinicaltrials.gov as #NCT03907553.

Published
2022

46. Cognition, function, and prevalent dementia in centenarians and near-centenarians: An individual participant data (IPD) meta-analysis of 18 studies.

Author

Leung, Yvonne, Leung, Yvonne, Barzilai, Nir, Batko-Szwaczka, Agnieszka, Beker, Nina, Boerner, Kathrin, Brayne, Carol, Brodaty, Henry, Cheung, Karen Siu-Lan, Corrada, María M, Crawford, John D, Galbussera, Alessia A, Gondo, Yasuyuki, Holstege, Henne, Hulsman, Marc, Ishioka, Yoshiko Lily, Jopp, Daniela, Kawas, Claudia H, Kaye, Jeff, Kochan, Nicole A, Lau, Bobo Hi-Po, Lipnicki, Darren M, Lo, Jessica W, Lucca, Ugo, Makkar, Steve R, Marcon, Gabriella, Martin, Peter, Meguro, Kenichi, Milman, Sofiya, Poon, Leonard W, Recchia, Angela, Ribeiro, Oscar, Riva, Emma, Rott, Christoph, Sikkes, Sietske Am, Skoog, Ingmar, Stephan, Blossom, Szewieczek, Jan, Teixeira, Laetitia, Tettamanti, Mauro, Wilczyński, Krzysztof, Sachdev, Perminder, Leung, Yvonne, Leung, Yvonne, Barzilai, Nir, Batko-Szwaczka, Agnieszka, Beker, Nina, Boerner, Kathrin, Brayne, Carol, Brodaty, Henry, Cheung, Karen Siu-Lan, Corrada, María M, Crawford, John D, Galbussera, Alessia A, Gondo, Yasuyuki, Holstege, Henne, Hulsman, Marc, Ishioka, Yoshiko Lily, Jopp, Daniela, Kawas, Claudia H, Kaye, Jeff, Kochan, Nicole A, Lau, Bobo Hi-Po, Lipnicki, Darren M, Lo, Jessica W, Lucca, Ugo, Makkar, Steve R, Marcon, Gabriella, Martin, Peter, Meguro, Kenichi, Milman, Sofiya, Poon, Leonard W, Recchia, Angela, Ribeiro, Oscar, Riva, Emma, Rott, Christoph, Sikkes, Sietske Am, Skoog, Ingmar, Stephan, Blossom, Szewieczek, Jan, Teixeira, Laetitia, Tettamanti, Mauro, Wilczyński, Krzysztof, and Sachdev, Perminder

Abstract

IntroductionThere are limited data on prevalence of dementia in centenarians and near-centenarians (C/NC), its determinants, and whether the risk of dementia continues to rise beyond 100.MethodsParticipant-level data were obtained from 18 community-based studies (N = 4427) in 11 countries that included individuals ≥95 years. A harmonization protocol was applied to cognitive and functional impairments, and a meta-analysis was performed.ResultsThe mean age was 98.3 years (SD = 2.67); 79% were women. After adjusting for age, sex, and education, dementia prevalence was 53.2% in women and 45.5% in men, with risk continuing to increase with age. Education (OR 0.95;0.92-0.98) was protective, as was hypertension (odds ratio [OR] 0.51;0.35-0.74) in five studies. Dementia was not associated with diabetes, vision and hearing impairments, smoking, and body mass index (BMI).DiscussionAmong the exceptional old, dementia prevalence remains higher in the older participants. Education was protective against dementia, but other factors for dementia-free survival in C/NC remain to be understood.

Published
2022

48. Patient-Reported Symptoms and Sequelae 12 Months After COVID-19 in Hospitalized Adults: A Multicenter Long-Term Follow-Up Study

Author

Comelli, Agnese, primary, Viero, Giulia, additional, Bettini, Greta, additional, Nobili, Alessandro, additional, Tettamanti, Mauro, additional, Galbussera, Alessia Antonella, additional, Muscatello, Antonio, additional, Mantero, Marco, additional, Canetta, Ciro, additional, Martinelli Boneschi, Filippo, additional, Arighi, Andrea, additional, Brambilla, Paolo, additional, Vecchi, Maurizio, additional, Lampertico, Pietro, additional, Bonfanti, Paolo, additional, Contoli, Marco, additional, Blasi, Francesco, additional, Gori, Andrea, additional, and Bandera, Alessandra, additional

Published
2022
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49. Incidence of dementia in the oldest‐old and its relationship with age: The Monzino 80‐plus population‐based study

Author

Pietro Tiraboschi, Alessia A. Galbussera, Anna Biotti, Mariateresa Garrì, Ugo Lucca, Giancarlo Logroscino, Elena Gargantini, Sara Mandelli, Cristina Landi, Angela Recchia, Sonia Ammesso, Emma Riva, Alessandro Piedicorcia, Leonardo Sacco, and Mauro Tettamanti

Subjects
Male, Aging, medicine.medical_specialty, Epidemiology, Population, Neuropsychological Tests, Lower risk, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Developmental Neuroscience, Risk Factors, Surveys and Questionnaires, medicine, Humans, Dementia, Cumulative incidence, 030212 general & internal medicine, education, Aged, 80 and over, education.field_of_study, business.industry, Incidence, Health Policy, Incidence (epidemiology), medicine.disease, Oldest old, Population based study, Psychiatry and Mental health, Italy, Female, Neurology (clinical), Geriatrics and Gerontology, business, 030217 neurology & neurosurgery, Demography
Abstract

Introduction Relationship between age and dementia at extreme old ages is still an open question, yet population-based studies in this high-risk age segment are rare. Methods The Monzino 80-plus is a population-based study among residents 80 years and older in the Varese province, Italy. Of 1371 eligible individuals, 1294 (94.4%), of whom 64 are centenarians, were included in the incidence study. Results Since 2002, 584 new cases of all-cause dementia were identified over 15 years. The overall incidence rate was 7.9 per 100 person-years. Dementia risk rose with age (IRR: 1.06), with the cubic model providing the best fit (R2 = 0.91–0.96). Cumulative incidences of dementia unadjusted and adjusted for competing mortality risk progressively diverged with age. Conclusion Dementia incidence also keeps rising in nonagenarians and centenarians. Slowing down in growing risk of developing dementia with age is mainly attributable to increasing competing risk of death and resulting selective survival of individuals at lower risk of dementia.

Published
2020

50. Additional file 1 of Italian adaptation of the Uniform Data Set Neuropsychological Test Battery (I-UDSNB 1.0): development and normative data

Author

Conca, Francesca, Esposito, Valentina, Rundo, Francesco, Quaranta, Davide, Muscio, Cristina, Manenti, Rosa, Caruso, Giulia, Lucca, Ugo, Galbussera, Alessia Antonella, Di Tella, Sonia, Baglio, Francesca, L’Abbate, Federica, Canu, Elisa, Catania, Valentina, Filippi, Massimo, Mattavelli, Giulia, Poletti, Barbara, Silani, Vincenzo, Lodi, Raffaele, De Matteis, Maddalena, Stanzani Maserati, Michelangelo, Arighi, Andrea, Rotondo, Emanuela, Tanzilli, Antonio, Pace, Andrea, Garramone, Federica, Cavaliere, Carlo, Pardini, Matteo, Rizzetto, Cristiano, Sorbi, Sandro, Perri, Roberta, Tiraboschi, Pietro, Canessa, Nicola, Cotelli, Maria, Ferri, Raffaele, Weintraub, Sandra, Marra, Camillo, Tagliavini, Fabrizio, Catricalà, Eleonora, and Cappa, Stefano Francesco

Abstract

Additional file 1: Supplementary materials. Table S1. Correction grids for age, education and sex and Equivalent Scores for each test (when available). To correct the raw score, the examiner has to add/subtract the values indicated on the bases of the subject age and/or education and/or sex to the raw score. Corrected score is then assigned an Equivalent Score (when available) according to the corresponding grid of values.

Published
2022
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