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1. Confinement determines transport of a reaction-diffusion active matter front

Author

Lobato-Dauzier, Nicolas, Maitra, Ananyo, Estevez-Torres, André, and Galas, Jean-Christophe

Subjects
Condensed Matter - Soft Condensed Matter, Physics - Biological Physics
Abstract

Couplings between biochemical and mechanical processes have a profound impact on embryonic development. However, in-vitro studies capable of quantifying these interactions have remained elusive. Here, we investigate a synthetic system where a DNA reaction-diffusion (RD) front is advected by a turbulent flow generated by active matter (AM) flows in a quasi-one-dimensional geometry. Whereas the dynamics of simple RD fronts solely depend on the reaction and diffusion rates, we show that RD-AM front propagation is also influenced by the confinement geometry. We first experimentally dissected the different components of the reaction-diffusion-advection process by knocking out reaction or advection and observed how RD-AM allows for faster transport over large distances, avoiding dilution. We then show how confinement impacts active matter flow: while changes in instantaneous flow velocities are small; correlation times are dramatically increased with decreasing confinement. As a result, RD-AM front speed increased up to 8-fold compared to a RD one, in quantitative agreement with a conveyor belt RDA theoretical model. The RD-AM experimental system described here provides a framework for the rational engineering of complex spatiotemporal processes observed in living systems. It will reinforce our understanding of how macro-scale patterns and structures emerge from microscopic components in non-equilibrium systems., Comment: Addition of a conveyor belt reaction- diffusion-advection (RDA) model, see Fig. 5. Addition of Fig. 6 showing the agreement between the model and experimental results, with additional replicates

Published
2024

3. Challenges and success stories of the implementation of infection control and antimicrobial stewardship strategies: proceedings of the 5th Global Ministerial Summit on Patient Safety, 2023

Author

Büchler, Andrea C., Haddad Galas, Murielle, Buetti, Niccolò, Alp, Emine, Apisarnthanarak, Anucha, Dziekan, Gerald, Fabre, Valeria, Gottwalt, Simon, Jindai, Kazuaki, Ndoye, Babacar, Márquez Villareal, Hilda, Otaiza, Fernando, Pittet, Didier, Schellack, Natalie, Gardiol, Céline, and Harbarth, Stephan

Published
2024
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4. Progressive Excitability Changes in the Medial Entorhinal Cortex in the 3xTg Mouse Model of Alzheimers Disease Pathology.

Author

Christenson Wick, Zoé, Vetere, Lauren, Vaughan, Nick, Jurkowski, Albert, Galas, Angelina, Diego, Keziah, Philipsberg, Paul, Soler, Ivan, Feng, Yu, Cai, Denise, Shuman, Tristan, and Chen, Lingxuan

Subjects
Alzheimers disease, electrophysiology, excitability, medial entorhinal cortex, stellate cells, Animals, Male, Female, Mice, Alzheimer Disease, Entorhinal Cortex, Neurons, Hippocampus, Disease Models, Animal, Memory Disorders, Mice, Transgenic
Abstract

Alzheimers disease (AD) is a chronic neurodegenerative disorder characterized by memory loss and progressive cognitive impairments. In mouse models of AD pathology, studies have found neuronal and synaptic deficits in hippocampus, but less is known about changes in medial entorhinal cortex (MEC), which is the primary spatial input to the hippocampus and an early site of AD pathology. Here, we measured neuronal intrinsic excitability and synaptic activity in MEC layer II (MECII) stellate cells, MECII pyramidal cells, and MEC layer III (MECIII) excitatory neurons at 3 and 10 months of age in the 3xTg mouse model of AD pathology, using male and female mice. At 3 months of age, before the onset of memory impairments, we found early hyperexcitability in intrinsic properties of MECII stellate and pyramidal cells, but this was balanced by a relative reduction in synaptic excitation (E) compared with inhibition (I; E/I ratio), suggesting intact homeostatic mechanisms regulating MECII activity. Conversely, MECIII neurons had reduced intrinsic excitability at this early time point with no change in synaptic E/I ratio. By 10 months of age, after the onset of memory deficits, neuronal excitability of MECII pyramidal cells and MECIII excitatory neurons was largely normalized in 3xTg mice. However, MECII stellate cells remained hyperexcitable, and this was further exacerbated by an increased synaptic E/I ratio. This observed combination of increased intrinsic and synaptic hyperexcitability suggests a breakdown in homeostatic mechanisms specifically in MECII stellate cells at this postsymptomatic time point, which may contribute to the emergence of memory deficits in AD.SIGNIFICANCE STATEMENT AD causes cognitive deficits, but the specific neural circuits that are damaged to drive changes in memory remain unknown. Using a mouse model of AD pathology that expresses both amyloid and tau transgenes, we found that neurons in the MEC have altered excitability. Before the onset of memory impairments, neurons in layer 2 of MEC had increased intrinsic excitability, but this was balanced by reduced inputs onto the cell. However, after the onset of memory impairments, stellate cells in MEC became further hyperexcitable, with increased excitability exacerbated by increased synaptic inputs. Thus, it appears that MEC stellate cells are uniquely disrupted during the progression of memory deficits and may contribute to cognitive deficits in AD.

Published
2023

5. Wheel Squeal Mitigation Under Water Lubrication

Author

Václav Navrátil, Radovan Galas, Milan Klapka, Daniel Kvarda, and Milan Omasta

Subjects
wheel squeal noise, noise mitigation, friction management, water lubrication, wheel-rail tribology, Mechanical engineering and machinery, TJ1-1570
Abstract

This study investigates the potential of applying water to the wheel-rail contact to reduce squealing noise. For this purpose, a twin-disc device with a single tram wheel and real wheel suspension stiffnesses was developed. Three types of tests were performed. During the tests, adhesion coefficient, sound pressure level and wheel axial vibration were measured. The tests under dry conditions were carried out to describe the frequency spectrum of wheel vibration and to establish reference values for further measurements. The tests under wet conditions were carried out to investigate the ability of water to reduce adhesion and noise. Finally, tests with varying amounts of water in contact were carried out because of the low adhesion risk. The experimental results showed that the twin-disc device was able to reproduce both the adhesion and noise properties of the contact. Tests with different amounts of water showed that the application of water can be a promising way to reduce squealing noise from wheel-rail contact.

Published
2024
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6. A measurement system for CO2 and CH4 emissions quantification of industrial sites using a new in situ concentration sensor operated on board uncrewed aircraft vehicles

Author

J.-L. Bonne, L. Donnat, G. Albora, J. Burgalat, N. Chauvin, D. Combaz, J. Cousin, T. Decarpenterie, O. Duclaux, N. Dumelié, N. Galas, C. Juery, F. Parent, F. Pineau, A. Maunoury, O. Ventre, M.-F. Bénassy, and L. Joly

Subjects
Environmental engineering, TA170-171, Earthwork. Foundations, TA715-787
Abstract

We developed and tested a complete measurement system to quantify CO2 and CH4 emissions at the scale of an industrial site based on the innovative sensor Airborne Ultra-light Spectrometer for Environmental Application (AUSEA), operated on board uncrewed aircraft vehicles (UAVs). The AUSEA sensor is a new light-weight (1.4 kg) open-path laser absorption spectrometer simultaneously recording in situ CO2 and CH4 concentrations at high frequency (24 Hz in this study) with precisions of 10 ppb for CH4 and 1 ppm for CO2 (when averaged at 1 Hz). It is suitable for industrial operation at a short distance from the sources (sensitivity up to 1000 ppm for CO2 and 200 ppm for CH4). Greenhouse gas concentrations monitored by this sensor throughout a plume cross section downwind of a source drive a simple mass balance model to quantify emissions from this source. This study presents applications of this method to different pragmatic cases representative of real-world conditions for oil and gas facilities. Two offshore oil and gas platforms were monitored for which our emissions estimates were coherent with mass balance and combustion calculations from the platforms. Our method has also been compared to various measurement systems (gas lidar, multispectral camera, infrared camera including concentrations and emissions quantification system, acoustic sensors, ground mobile and fixed cavity ring-down spectrometers) during controlled-release experiments conducted on the TotalEnergies Anomaly Detection Initiatives (TADI) test platform at Lacq, France. It proved suitable to detect leaks with emission fluxes down to 0.01 g s−1, with 24 % of estimated CH4 fluxes within the −20 % to +20 % error range, 80 % of quantifications within the −50 % to +100 % error range and all of our results within the −69 % to +150 % error range. Such precision levels are better ranked than current top-down alternative techniques to quantify CH4 at comparable spatial scales. This method has the potential to be operationally deployed on numerous sites and on a regular basis to evaluate the space- and time-dependent greenhouse gas emissions of oil and gas facilities.

Published
2024
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8. Development of a hub-and-spoke durable left ventricular assist device program in Brazil, a middle-income country

Author

Deborah de Sá Pereira Belfort, Bruno Biselli, Mônica Samuel Avila, Renata Lopes Hames, Stephanie Itala Rizk, Fabrício Canova Calil, Bruna Carneiro Oliveira, Filomena Regina Barbosa Gomes Galas, Ludhmila Abrahão Hajjar, Nadine Oliveira Clausell, Livia Adams Goldraich, Ramez Anbar, Edimar Alcides Bocchi, Tadeu Thomé, Roberto Kalil Filho, Paulo Manuel Pêgo-Fernandes, Fabio Biscegli Jatene, and Silvia Moreira Ayub-Ferreira

Subjects
left ventricular assist device, survival analysis, middle-income countries, hub-and-spoke, heart failure, Surgery, RD1-811, Specialties of internal medicine, RC581-951
Abstract

Background: In middle-income countries, costs limit widespred use of left ventricular assist device (LVAD) as a strategy for end-stage heart failure. We aim to describe the experience of a LVAD program in a middle-income country in a hub-and-spoke model. Methods: Patients fulfilling strict inclusion and exclusion criteria were referred from different centers in Brazil for LVAD implantation through a philanthropy program financed via a Brazilian Federal Government tax exemption structure. LVAD implantation was performed in a hub-and-spoke model with a single implanting center. Data were collected retrospectively using hospital records and telephone contact with other centers. Patients who received LVAD implants external to the philanthropic program, either at this or other Brazilian centers, were not included. Results: Between January 1, 2013 and December 31, 2020, 20 adult patients underwent long-term continuous flow LVAD implantation with decentralization of postimplant patient care in regional centers. Patients were referred from 11 centers from 7 states in Brazil and underwent LVAD implantation through a philanthropy program. The median age was 52.5 years and 85% were Interagency Registry for Mechanically Assisted Circulatory Support profile 3 patients. Two patients had Chagas cardiomyopathy. The overall survival censored for competing risks at 1 and 2 years were 90% and 84%, respectively. Three patients (15%) underwent heart transplantation in the first 2 years after LVAD implantation. Twelve patients returned to their original centers and were followed remotely. Conclusions: This study presents a successful LVAD implantation program in a hub-and-spoke model in Brazil. Centralization of LVAD implantation with decentralization of postimplant patient care in regional centers is feasible and safe, enabling optimal allocation of resources in middle-income countries.

Published
2024
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11. Modified TruSeq Small RNA Library Prep using Randomized 4N Adapters: In house 4N Protocol D

Author

Alexander, Roger P, Giraldez, MD, Spengler, RM, Etheridge, A, Godoy, PM, Barczak, AJ, Srinivasan, S, De Hoff, PL, Tanriverdi, K, Courtright, A, Lu, S, Khoory, J, Rubio, R, Baxter, D, Driedonks, TAP, Buermans, HPJ, Nolte-t Hoen, ENM, Jiang, H, Wang, K, Ghiran, I, Wang, Y, Van Keuren-Jensen, K, Freedman, JE, Woodruff, PG, Laurent, LC, Erle, DJ, Galas, DJ, and Tewari, M

Published
2023

12. Library Preparation for small RNA sequencing using 4N adapters: In house 4N Protocol C

Author

Alexander, Roger P, Giraldez, MD, Spengler, RM, Etheridge, A, Godoy, PM, Barczak, AJ, Srinivasan, S, De Hoff, PL, Tanriverdi, K, Courtright, A, Lu, S, Khoory, J, Rubio, R, Baxter, D, Driedonks, TAP, Buermans, HPJ, Nolte-t Hoen, ENM, Jiang, H, Wang, K, Ghiran, I, Wang, Y, Van Keuren-Jensen, K, Freedman, JE, Woodruff, PG, Laurent, LC, Erle, DJ, Galas, DJ, and Tewari, M

Published
2023

13. Library Preparation for small RNA sequencing using 4N adapters: In house 4N Protocol B

Author

Alexander, Roger P, Giraldez, MD, Spengler, RM, Etheridge, A, Godoy, PM, Barczak, AJ, Srinivasan, S, De Hoff, PL, Tanriverdi, K, Courtright, A, Lu, S, Khoory, J, Rubio, R, Baxter, D, Driedonks, TAP, Buermans, HPJ, Nolte-t Hoen, ENM, Jiang, H, Wang, K, Ghiran, I, Wang, Y, Van Keuren-Jensen, K, Freedman, JE, Woodruff, PG, Laurent, LC, Erle, DJ, Galas, DJ, and Tewari, M

Published
2023

14. Library Preparation for small RNA sequencing using 4N adapters: In house 4N Protocol A

Author

Alexander, Roger P, Giraldez, MD, Spengler, RM, Etheridge, A, Godoy, PM, Barczak, AJ, Srinivasan, S, De Hoff, PL, Tanriverdi, K, Courtright, A, Lu, S, Khoory, J, Rubio, R, Baxter, D, Driedonks, TAP, Buermans, HPJ, Nolte-t Hoen, ENM, Jiang, H, Wang, K, Ghiran, I, Wang, Y, Van Keuren-Jensen, K, Freedman, JE, Woodruff, PG, Laurent, LC, Erle, DJ, Galas, DJ, and Tewari, M

Published
2023

16. Efficacy of bupropion and varenicline genetic markers in choosing pharmacological treatment for smoking cessation, and implications for combining drugs: A randomized controlled trial (GENTSMOKING)

Author

Patricia V. Gaya, Juliana R. Santos, Paulo R. X. Tomaz, Tania M. O. Abe, Miguel Nassif Jr, Larissa G. Galas, Bianca B. Bellini, Iana R. Moraes, Paulo C. Lima Santos, Paulo C. R. P. Correa, and Jaqueline R. Scholz

Subjects
precision medicine, varenicline, bupropion, smoking cessation, pharmacogenetics, Diseases of the respiratory system, RC705-779, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Introduction Smoking cessation is the best strategy for reducing tobacco-related morbimortality. The goal of this randomized controlled trial was to test whether using the genetically favorable markers to choose a smoking cessation drug treatment (precision medicine) was superior to using the most effective drug (varenicline) in terms of abstinence rates. Additionally, combination therapy was tested when monotherapy failed. Methods This partially blind, single-center study randomized (1:1) 361 participants into two major groups. In the genetic group (n=184), CYP2B6 rs2279343 (genotype AA) participants started treatment with bupropion, and CHRNA4 rs1044396 (genotype CT or TT) participants started treatment with varenicline; when genetic favorable to both, participants started treatment with bupropion, and when favorable to neither, on both drugs. In the control group (n=177), participants started treatment with varenicline, regardless of genetic markers. Drug treatment lasted 12 weeks. Efficacy endpoints were abstinence rates at Weeks 4, and Weeks 8–12, biochemically validated by carbon monoxide in exhaled air. Participants who did not achieve complete abstinence at Week 4, regardless of group, were given the choice to receive combination therapy. Results Abstinence rates were 42.9% (95% CI: 36–64) in the control group versus 30.4% (95% CI: 23–37) in the genetic group at Week 4 (p=0.01); and 74% (95% CI: 67–80) versus 52% (95% CI: 49–64) at Week 12 (p

Published
2024
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17. Surveillance of catheter-associated bloodstream infections: development and validation of a fully automated algorithm

Author

Gaud Catho, Loïc Fortchantre, Daniel Teixeira, Murielle Galas-Haddad, Filippo Boroli, Marie-Noëlle Chraïti, Mohamed Abbas, Stephan Harbarth, Niccolò Buetti, and Swissnoso group

Subjects
Sensitivity, Specificity, Healthcare associated infections, CLABSI, Bloodstream infection, Catheter-infection, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Most surveillance systems for catheter-related bloodstream infections (CRBSI) and central line-associated bloodstream infections (CLABSI) are based on manual chart review. Our objective was to validate a fully automated algorithm for CRBSI and CLABSI surveillance in intensive care units (ICU). Methods We developed a fully automated algorithm to detect CRBSI, CLABSI and ICU-onset bloodstream infections (ICU-BSI) in patients admitted to the ICU of a tertiary care hospital in Switzerland. The parameters included in the algorithm were based on a recently performed systematic review. Structured data on demographics, administrative data, central vascular catheter and microbiological results (blood cultures and other clinical cultures) obtained from the hospital’s data warehouse were processed by the algorithm. Validation for CRBSI was performed by comparing results with prospective manual BSI surveillance data over a 6-year period. CLABSI were retrospectively assessed over a 2-year period. Results From January 2016 to December 2021, 854 positive blood cultures were identified in 346 ICU patients. The median age was 61.7 years [IQR 50–70]; 205 (24%) positive samples were collected from female patients. The algorithm detected 5 CRBSI, 109 CLABSI and 280 ICU-BSI. The overall CRBSI and CLABSI incidence rates determined by automated surveillance for the period 2016 to 2021 were 0.18/1000 catheter-days (95% CI 0.06–0.41) and 3.86/1000 catheter days (95% CI: 3.17–4.65). The sensitivity, specificity, positive predictive and negative predictive values of the algorithm for CRBSI, were 83% (95% CI 43.7–96.9), 100% (95% CI 99.5–100), 100% (95% CI 56.5–100), and 99.9% (95% CI 99.2–100), respectively. One CRBSI was misclassified as an ICU-BSI by the algorithm because the same bacterium was identified in the blood culture and in a lower respiratory tract specimen. Manual review of CLABSI from January 2020 to December 2021 (n = 51) did not identify any errors in the algorithm. Conclusions A fully automated algorithm for CRBSI and CLABSI detection in critically-ill patients using only structured data provided valid results. The next step will be to assess the feasibility and external validity of implementing it in several hospitals with different electronic health record systems.

Published
2024
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19. Health-related quality of life and self-care in heart failure patients under telecare—insights from the randomized, prospective, controlled AMULET trial

Author

Katarzyna Piotrowicz, Paweł Krzesiński, Agata Galas, Adam Stańczyk, Janusz Siebert, Ewa Anita Jankowska, Paweł Siwołowski, Piotr Gutknecht, Piotr Murawski, Dominika Szalewska, Waldemar Banasiak, Piotr Ponikowski, and Grzegorz Gielerak

Subjects
heart failure, health-related quality of life, self-care, telecare, heart failure management, Public aspects of medicine, RA1-1270
Abstract

IntroductionThe growing population of heart failure (HF) patients places a burden on the healthcare system. Patient-centered outcomes such as health-related quality of life (HRQoL) and self-care behaviors are key elements of modern HF management programs. Thus, optimized strategies to improve these outcomes are sought.PurposeTo assess the effects of a new model of medical telecare on HRQoL and self-care in patients with HF (the AMULET study).MethodsThe study was prospective, randomized, open-label, and controlled with two parallel groups: telecare and standard care. In the telecare group, HF nurses performed patient clinical assessments with telemedical support by a cardiologist and provided education focused on the prevention of HF exacerbation. In the standard care group, patients were followed according to standard practices in the existing healthcare system. At the baseline and at 12 months, HRQoL was assessed using the Short Form 36 (SF-36) questionnaire and the Minnesota Living with Heart Failure Questionnaire (MLwHF). The level of self-care was assessed with the 12-item standardized European Heart Failure Self-care Behavior Scale (EHFScBS-12).ResultsIn the overall study group, 79% of the subjects were male, the mean age was 67 ± 14 years, and 59% of the subjects were older than 65 years of age. The majority of the subjects (70%) had a left ventricular ejection fraction below 40%. After 12 months, statistically significant increases in physical component of the SF-36 (43.3 vs. 47.4 for telecare vs. 43.4 vs. 46.6 for standard care) and mental component of SF-36 (58.4 vs. 62 for telecare vs. 60.4 vs. 64.2 for standard care) were noted, with no intergroup differences. However, patients receiving telecare showed improvement in specific domains, such as physical functioning, role-physical, bodily pain, vitality, social functioning, role-emotional, and mental health. There was a significant decrease in MLwHF (29 vs. 35.0; lower is better) at follow-up for both groups. Telecare patients had a statistically significant decrease in EHFScBS-12 (lower is better) at 12 months.ConclusionAMULET outpatient telecare, which is based on nurse-led non-invasive assessments supported by specialist teleconsultations, improved the HRQoL and self-care of HF patients after an episode of acute HF.

Published
2024
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20. Impact of Hemoglobin Levels on Composite Cardiac Arrest or Stroke Outcome in Patients With Respiratory Failure Due to COVID-19

Author

Shi Nan Feng, BSPH, Thu-Lan Kelly, PhD, John F. Fraser, MD, PhD, Gianluigi Li Bassi, MD, PhD, Jacky Suen, PhD, Akram Zaaqoq, MD, MPH, Matthew J. Griffee, MD, Rakesh C. Arora, MD, Nicole White, PhD, Glenn Whitman, MD, Chiara Robba, MD, PhD, Denise Battaglini, MD, PhD, Sung-Min Cho, DO, MHS, on behalf of COVID-19 Critical Care Consortium (CCCC), Robert Bartlett, John F. Fraser, Gianluigi Li Bassi, Jacky Y. Suen, Heidi J. Dalton, John Laffey, Daniel Brodie, Eddy Fan, Antoni Torres, Davide Chiumello, Alyaa Elhazm, Carol Hodgson, Shingo Ichiba, Carlos Luna, Srinivas Murthy, Alistair Nichol, Pauline Yeung Ng, Mark Ogino, Aidan Burrell, Antonio Pesenti, Tala Al-Dabbous, Huda Alfoudri, Mohammed Shamsah, Subbarao Elapavaluru, Ashley Berg, Christina Horn, Yunis Mayasi, Stephan Schroll, Dan Meyer, Jorge Velazco, Ludmyla Ploskanych, Wanda Fikes, Rohini Bagewadi, Marvin Dao, Haley White, Alondra Berrios Laviena, Ashley Ehlers Maysoon, Shalabi-McGuire, Trent Witt, Lorenzo Grazioli, Luca Lorini, E. Wilson Grandin, Jose Nunez, Tiago Reyes, Diarmuid O’Briain, Stephanie Hunter, Mahesh Ramanan, Julia Affleck, Hemanth Hurkadli Veerendra, Sumeet Rai, Josie Russell-Brown, Mary Nourse, Mark Joseph, Brook Mitchell, Martha Tenzer, Ryuzo Abe, Hwa Jin Cho, In Seok Jeong, Nadeem Rahman, Vivek Kakar, Andres Oswaldo Razo Vazquez, Nicolas Brozzi, Omar Mehkri, Sudhir Krishnan Abhijit, Duggal Stuart Houltham, Jerónimo Graf, Roderigo Diaz, Roderigo Orrego, Camila Delgado, Joyce González, Maria Soledad Sanchez, Michael Piagnerelli, Josefa Valenzuela Sarrazin, A/Prof. Gustavo Zabert, Lucio Espinosa, Paulo Delgado, Victoria Delgado, Diego Fernando, Bautista Rincón, Angela Maria Marulanda Yanten, Melissa Bustamante Duque, Alyaa Elhazmi, Abdullah Al-Hudaib, Maria Callahan, M. Azhari Taufik, Elizabeth Yasmin Wardoyo, Margaretha Gunawan, Nurindah S Trisnaningrum, Vera Irawany, Muhammad Rayhan, Mauro Panigada, Alberto Zanella, Giacomo Grasselli, Sebastiano Colombo, Chiara Martinet, Gaetano Florio, Massimo Antonelli, Simone Carelli, Domenico L. Grieco, Motohiro Asaki, Kota Hoshino, Leonardo Salazar, Mary Alejandra Mendoza Monsalve, Bairbre McNicholas, David Cosgrave, Joseph McCaffrey, Allison Bone, Yusuff Hakeem, James Winearls, Mandy Tallott, David Thomson, Christel Arnold-Day, Jerome Cupido, Zainap Fanie, Malcom Miller, Lisa Seymore, Dawid van Straaten, Ali Ait Hssain, Jeffrey Aliudin, Al-Reem Alqahtani, Khoulod Mohamed, Ahmed Mohamed, Darwin Tan, Joy Villanueva, Ahmed Zaqout, Ethan Kurtzman, Arben Ademi, Ana Dobrita, Khadija El Aoudi, Juliet Segura, Gezy Giwangkancana, Shinichiro Ohshimo, Javier Osatnik, Anne Joosten, Minlan Yang, Ana Motos, Francisco Arancibia, Virginie Williams, Alexandre Noel, Nestor Luque, Marina Fantini, Ruth Noemi Jorge García, Enrique Chicote Alvarez, Anna Greti, Adrian Ceccato, Angel Sanchez, Ana Loza Vazquez, Ferran Roche-Campo, Diego Franch-Llasat, Divina Tuazon, Marcelo Amato, Luciana Cassimiro, Flavio Pola, Francis Ribeiro, Guilherme Fonseca, Heidi Dalton, Mehul Desai, Erik Osborn Hala Deeb, Antonio Arcadipane, Gennaro Martucci, Giovanna Panarello, Chiara Vitiello, Claudia Bianco, Giovanna Occhipinti, Matteo Rossetti, Raffaele Cuffaro, Sung-Min Cho, Glenn Whitman, Hiroaki Shimizu, Naoki Moriyama, Jae-Burm Kim, Nobuya Kitamura, Johannes Gebauer, Toshiki Yokoyama, Abdulrahman Al-Fares, Sarah Buabbas, Esam Alamad, Fatma Alawadhi, Kalthoum Alawadi, Hiro Tanaka, Satoru Hashimoto, Masaki Yamazaki, Tak-Hyuck Oh, Mark Epler, Cathleen Forney, Louise Kruse, Jared Feister, Joelle Williamson, Katherine Grobengieser, Eric Gnall, Sasha Golden, Mara Caroline, Timothy Shapiro, Colleen Karaj, Lisa Thome, Lynn Sher, Mark Vanderland, Mary Welch, Sherry McDermott, Matthew Brain, Sarah Mineall, Dai Kimura, Luca Brazzi, Gabriele Sales, Giorgia Montrucchio, Tawnya Ogston, Dave Nagpal, Karlee Fischer, Roberto Lorusso, Rajavardhan Rangappa, Sujin Rai, Argin Appu, Mariano Esperatti, Nora Angélica Fuentes, Maria Eugenia Gonzalez, Edmund G. Carton, Ayan Sen, Amanda Palacios, Deborah Rainey, Gordan Samoukoviv, Josie Campisi, Lucia Durham, Emily Neumann, Cassandra Seefeldt, Octavio Falcucci, Amanda Emmrich, Jennifer Guy, Carling Johns, Kelly Potzner, Catherine Zimmermann, Angelia Espinal, Nina Buchtele, Michael Schwameis, Andrea Korhnfehl, Roman Brock, Thomas Staudinger, Stephanie-Susanne, Stecher Michaela Barnikel, Sófia Antón, Alexandra Pawlikowski, Akram Zaaqoq, Lan Anh Galloway, Caitlin Merley, Marc Csete, Luisa Quesada, Isabela Saba, Daisuke Kasugai, Hiroaki Hiraiwa, Taku Tanaka, Eva Marwali, Yoel Purnama, Santi Rahayu Dewayanti, Ardiyan, Dafsah Arifa Juzar, Debby Siagian, Yih-Sharng Chen, Indrek Ratsep, Andra-Maris Post, Piret Sillaots, Anneli Krund, Merili-Helen Lehiste, Tanel Lepik, Frank Manetta, Effe Mihelis, Iam Claire Sarmiento, Mangala Narasimhan, Michael Varrone, Mamoru Komats, Julia Garcia-Diaz, Catherine Harmon, S. Veena Satyapriya, Amar Bhatt, Nahush A. Mokadam, Alberto Uribe, Alicia Gonzalez, Haixia Shi, Johnny McKeown, Joshua Pasek, Juan Fiorda, Marco Echeverria, Rita Moreno, Bishoy Zakhary, Marco Cavana, Alberto Cucino, Giuseppe Foti, Marco Giani, Benedetta Fumagalli, Valentina Castagna, Andrea Dell’Amore, Paolo Navalesi, Hoi-Ping Shum, Alain Vuysteke, Asad Usman, Andrew Acker, Benjamin Smood, Blake Mergler, Federico Sertic, Madhu Subramanian, Alexandra Sperry, Nicolas Rizer, Erlina Burhan, Menaldi Rasmin, Ernita Akmal, Faya Sitompul, Navy Lolong, Bhat Naivedh, Simon Erickson, Peter Barrett, David Dean, Julia Daugherty, Antonio Loforte, Irfan Khan, Mohammed Abraar Quraishi, Olivia DeSantis, Dominic So, Darshana Kandamby, Jose M. Mandei, Hans Natanael, Eka YudhaLantang, Anastasia Lantang, Surya Oto Wijaya, Anna Jung, George Ng, Wing Yiu Ng, Shu Fang, Alexis Tabah, Megan Ratcliffe, Maree Duroux, Shingo Adachi, Shota Nakao, Pablo Blanco, Ana Prieto, Jesús Sánchez, Meghan Nicholson, Warwick Butt, Alyssa Serratore, Carmel Delzoppo, Pierre Janin, Elizabeth Yarad, Richard Totaro, Jennifer Coles, Bambang Pujo, Robert Balk, Andy Vissing, Esha Kapania, James Hays, Samuel Fox, Garrett Yantosh, Pavel Mishin, Saptadi Yuliarto, Kohar Hari Santoso, Susanthy Djajalaksana, Arie Zainul Fatoni, Masahiro Fukuda, Keibun Liu, Paolo Pelosi, Denise Battaglini, Juan Fernando Masa Jiménez, Diego Bastos, Sérgio Gaião, Desy Rusmawatiningtyas, Young-Jae Cho, Su Hwan Lee, Tatsuya Kawasaki, Laveena Munshi, Pranya Sakiyalak, Prompak Nitayavardhana, Tamara Seitz, Rakesh Arora, David Kent, Daniel Marino, Swapnil Parwar, Andrew Cheng, Jennene Miller, Shigeki Fujitani, Naoki Shimizu, Jai Madhok, Clark Owyang, Hergen Buscher, Claire Reynolds, Olavi Maasikas, Aleksan Beljantsev, Vladislav Mihnovits, Takako Akimoto, Mariko Aizawa, Kanako Horibe, Ryota Onodera, Meredith Young, Timothy George, Kiran Shekar, Niki McGuinness, Lacey Irvine, Brigid Flynn, Tomoyuki Endo, Kazuhiro Sugiyama, Keiki Shimizu, Kathleen Exconde, Leslie Lussier, Gösta Lotz, Maximilian Malfertheiner, Lars Maier, Esther Dreier, Neurinda Permata Kusumastuti, Colin McCloskey, Al-Awwab Dabaliz, Tarek B Elshazly, Josiah Smith, Konstanty S. Szuldrzynski, Piotr Bielański, Keith Wille, Ken Kuljit, S. Parhar, Kirsten M. Fiest, Cassidy Codan, Anmol Shahid, Mohamed Fayed, Timothy Evans, Rebekah Garcia, Ashley Gutierrez, Tae Song, Rebecca Rose, Suzanne Bennett, Denise Richardson, Giles Peek, Lovkesh Arora, Kristina Rappapport, Kristina Rudolph, Zita Sibenaller, Lori Stout, Alicia Walter, Daniel Herr, Nazli Vedadi, Shaun Thompson, Julie Hoffman, Xiaonan Ying, Ryan Kennedy, Muhammed Elhadi, Matthew Griffee, Anna Ciullo, Yuri Kida, Ricard Ferrer Roca, JordI Riera, Sofia Contreras, Cynthia Alegre, Christy Kay, Irene Fischer, Elizabeth Renner, Hayato Taniguci, John Fraser, Jacky Suen, Adrian Barnett, Nicole White, Kristen Gibbons, Simon Forsyth, Amanda Corley, India Pearse, Samuel Hinton, Gabriella Abbate, Halah Hassan, Silver Heinsar, Varun A Karnik, Katrina Ki, Hollier F. O’Neill, Nchafatso Obonyo, Leticia Pretti Pimenta, Janice D. Reid, Kei Sato, Aapeli Vuorinen, Karin S. Wildi, Emily S. Wilson, Stephanie Yerkovich, James Lee, Daniel Plotkin, Barbara Wanjiru Citarella, Laura Merson, Emma Hartley, Bastian Lubis, Takanari Ikeyama, Balu Bhaskar, Jae-Seung Jung, Shay McGuinness, Glenn Eastwood, Sandra Rossi Marta, Fabio Guarracino, Stacy Gerle, Emily Coxon, Bruno Claro, Daniel Loverde, Namrata Patil, Vieri Parrini, Angela McBride, Kathryn Negaard, Angela Ratsch, Ahmad Abdelaziz, Juan David Uribe, Adriano Peris, Mark Sanders, Dominic Emerson, Muhammad Kamal, Pedro Povoa, Roland Francis, Ali Cherif, Sunimol Joseph, Matteo Di Nardo, Micheal Heard, Kimberly Kyle, Ray A Blackwell, Patrick Biston, Hye Won Jeong, Reanna Smith, Yogi Prawira, Arturo Huerta Garcia, Nahikari Salterain, Bart Meyns, Marsha Moreno, Rajat Walia, Amit Mehta, Annette Schweda, Moh Supriatna, Cenk Kirakli, Melissa Williams, Kyung Hoon Kim, Alexandra Assad, Estefania Giraldo, Wojtek Karolak, Martin Balik, Elizabeth Pocock, Evan Gajkowski, Kanamoto Masafumi, Nicholas Barrett, Yoshihiro Takeyama, Sunghoon Park, Faizan Amin, Fina Meilyana Andriyani, Serhii Sudakevych, Magdalena Vera, Rodrigo Cornejo, Patrícia Schwarz, Ana Carolina Mardini, Thais de Paula, Ary Serpa Neto, Andrea Villoldo, Alexandre Siciliano Colafranceschi, Alejandro Ubeda Iglesias, Juan Granjean, Lívia Maria Garcia Melro, Giovana Fioravante Romualdo, Diego Gaia, Helmgton Souza, Filomena Galas, Rafael Máñez Mendiluce, Alejandra Sosa, Ignacio Martinez, Hiroshi Kurosawa, Juan Salgado, Beate Hugi-Mayr, Eric Charbonneau, Vitor Salvatore Barzilai, Veronica Monteiro, Rodrigo Ribeiro de Souza, Michael Harper, Hiroyuki Suzuki, Celina Adams, Jorge Brieva, George Nyale, Faisal Saleem Eltatar, Jihan Fatani, Husam Baeissa, Ayman AL Masri, Ahmed Rabie, Mok Yee Hui, Masahiro Yamane, Hanna Jung, Ayorinde Mojisola Margaret, Newell Nacpil, Katja Ruck, Rhonda Bakken, Claire Jara, Tim Felton, Lorenzo Berra, Bobby Shah, Arpan Chakraborty, Monika Cardona, Gerry Capatos, Bindu Akkanti, Abiodun Orija, Harsh Jain, Asami Ito, Brahim Housni, Sennen Low, Koji Iihara, Joselito Chavez, Kollengode Ramanathan, Gustavo Zabert, Krubin Naidoo, Ian Seppelt, Marlice VanDyk, Sarah MacDonald, Randy McGregor, Teka Siebenaler, Hannah Flynn, Kristi Lofton, Toshiyuki Aokage, Kazuaki Shigemitsu, Andrea Moscatelli, Giuseppe Fiorentino, Matthias Baumgaertel, Serge Eddy Mba, Jana Assy, Amelya Hutahaean, Holly Roush, Kay A Sichting, Francesco Alessandri, Debra Burns, Gavin Salt, Carl P. Garabedian, Jonathan Millar, Malcolm Sim, Adrian Mattke, Danny McAuley, Jawad Tadili, Tim Frenzel, Yaron Bar-Lavie, Aaron Blandino Ortiz, Jackie Stone, Antony Attokaran, Michael Farquharson, Brij Patel, Derek Gunning, Kenneth Baillie, Pia Watson, Kenji Tamai, Gede Ketut Sajinadiyasa, Dyah Kanyawati, Marcello Salgado, Assad Sassine, Bhirowo Yudo, Scott McCaul, Bongjin Lee, Sang Min Lee, Arnon Afek, Yoshiaki Iwashita, Bambang Pujo Semedi, Jack Metiva, Nicole Van Belle, Ignacio Martin-Loeches, Lenny Ivatt, Chia Yew Woon, Hyun Mi Kang, Timothy Smith, Erskine James, Nawar Al-Rawas, Yudai Iwasaki, Kenny Chan King-Chung, Vadim Gudzenko, Fabio Taccone, Fajar Perdhana, Yoan Lamarche, Joao Miguel Ribeiro, Nikola Bradic, Klaartje Van den Bossche, Oude Lansink, Gurmeet Singh, Gerdy Debeuckelaere, Henry T. Stelfox, Cassia Yi, Jennifer Elia, Thomas Tribble, Shyam Shankar, Raj Padmanabhan, Bill Hallinan, Luca Paoletti, Yolanda Leyva, Tatuma Fykuda, Jenelle Badulak, Jillian Koch, Amy Hackman, Lisa Janowaik, Deb Hernandez, Jennifer Osofsky, Katia Donadello, Aizah Lawang, Josh Fine, and Benjamin Davidson

Subjects
Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

OBJECTIVES:. Anemia has been associated with an increased risk of both cardiac arrest and stroke, frequent complications of COVID-19. The effect of hemoglobin level at ICU admission on a composite outcome of cardiac arrest or stroke in an international cohort of COVID-19 patients was investigated. DESIGN:. Retrospective analysis of prospectively collected database. SETTING:. A registry of COVID-19 patients admitted to ICUs at over 370 international sites was reviewed for patients diagnosed with cardiac arrest or stroke up to 30 days after ICU admission. Anemia was defined as: normal (hemoglobin ≥ 12.0 g/dL for women, ≥ 13.5 g/dL for men), mild (hemoglobin 10.0–11.9 g/dL for women, 10.0–13.4 g/dL for men), moderate (hemoglobin ≥ 8.0 and < 10.0 g/dL for women and men), and severe (hemoglobin < 8.0 g/dL for women and men). PATIENTS:. Patients older than 18 years with acute COVID-19 infection in the ICU. INTERVENTIONS:. None. MEASUREMENTS AND MAIN RESULTS:. Of 6926 patients (median age = 59 yr, male = 65%), 760 patients (11.0%) experienced stroke (2.0%) and/or cardiac arrest (9.4%). Cardiac arrest or stroke was more common in patients with low hemoglobin, occurring in 12.8% of patients with normal hemoglobin, 13.3% of patients with mild anemia, and 16.7% of patients with moderate/severe anemia. Time to stroke or cardiac arrest by anemia status was analyzed using Cox proportional hazards regression with death as a competing risk. Covariates selected through clinical knowledge were age, sex, comorbidities (diabetes, hypertension, obesity, and cardiac or neurologic conditions), pandemic era, country income, mechanical ventilation, and extracorporeal membrane oxygenation. Moderate/severe anemia was associated with a higher risk of cardiac arrest or stroke (hazard ratio, 1.32; 95% CI, 1.05–1.67). CONCLUSIONS:. In an international registry of ICU patients with COVID-19, moderate/severe anemia was associated with increased hazard of cardiac arrest or stroke.

Published
2024
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21. Development of a hub-and-spoke durable left ventricular assist device program in Brazil, a middle-income country

Author

Belfort, Deborah de Sá Pereira, Biselli, Bruno, Avila, Mônica Samuel, Hames, Renata Lopes, Rizk, Stephanie Itala, Calil, Fabrício Canova, Oliveira, Bruna Carneiro, Galas, Filomena Regina Barbosa Gomes, Hajjar, Ludhmila Abrahão, Clausell, Nadine Oliveira, Goldraich, Livia Adams, Anbar, Ramez, Bocchi, Edimar Alcides, Thomé, Tadeu, Filho, Roberto Kalil, Pêgo-Fernandes, Paulo Manuel, Jatene, Fabio Biscegli, and Ayub-Ferreira, Silvia Moreira

Published
2024
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22. Stroke in critically ill patients with respiratory failure due to COVID-19: Disparities between low-middle and high-income countries

Author

Al-Dabbous, Tala, Alfoudri, Huda, Shamsah, Mohammed, Alfroukh, Khadeejeh, Bairmani, Zinah Aqeel Abdulzahra, Khalid, Khalid Jehad, Abukhalaf, Salsabeel M.A., Hadhoud, Mohammed Maher, Abdrabo, Mohamed Fouad, Fathi, Mohamed, Alhouri, Hasan, Shahla, Dr Hamza, Alhadad, Qamrah, Hanan, Matly, Elapavaluru, Subbarao, Berg, Ashley, Horn, Christina, Abdelhalim, Ahmed Reda Mohamed Elsayed, Amer, Amro Essam, Elnaggar, Cinderella Omar Rageh, Hassan, Ahmed Ayman, Abdelaziz, Ali, Abdelhalim, Mohamed, Orabi, Yehia Samir Shaaban Aly, Alaraji, Zinah A., Muhaisen, Mo'nes R., Almasri, Lana, Mustafa, Dana, Hamdan, Shaher, Al-Saba'a, Yousef, Dalloul, Zaina, Alkahlout, Mohammed, Jaber, Hamza, Aldabbourosama, Osama, Abdalhadi, Alaa Abdalfattah, Hussein, Aliae AR Mohamed, Emad, Zarief Kamel, Khaled, Sarah, Mohamed, Nouralsabah, Hassanin, Ebtisam, Hamdi, Abdelhafeez, Gamal, May, Emad, Ahmed, Ragab, Abdelrahman, Azizeldin, Mohammed G, Hamza, Almthani, Omer, Alsarrah Ali Mohammed, Fadl alla, Asgad Osman Abdalla, Abdallahrs, Asia Atif Abdelrahman, Eltayeb, Aml Ahmed, Alhasan, Maali khalid mohamed abdalla, Abdelgaum, Esraa Hassan, Ahmed, Aya Mustafa, Abdulbaqi, Lamees Adil, Mohammedelhassan, Omer Abdullah, Ahmed, Musaab Mohammed Mohammed, Ali, Maha TagElser Mohammed, Mayasi, Yunis, Schroll, Stephan, Meyer, Dan, Velazco, Jorge, Ploskanych, Ludmyla, Fikes, Wanda, Bagewadi, Rohini, Dao, Marvin, White, Haley, Laviena, Alondra Berrios, Ehlers, Ashley, Shalabi-McGuire, Maysoon, Witt, Trent, Grazioli, Lorenzo, Lorini, Luca, Grandin, E. Wilson, Nunez, Jose, Reyes, Tiago, O'Briain, Diarmuid, Hunter, Stephanie, Ramanan, Mahesh, Affleck, Julia, Veerendra, Hemanth Hurkadli, Rai, Sumeet, Russell-Brown, Josie, Nourse, Mary, Joseph, Mark, Mitchell, Brook, Tenzer, Martha, Abe, Ryuzo, Cho, Hwa Jin, Jeong, In Seok, Rahman, Nadeem, Kakar, Vivek, Tamimi, Ahmed, Zabalawi, Diala, Elhennawi, Mohamed, Ghisulal, Praveen, Malik, Sadaf, Brozzi, Nicolas, Mehkri, Omar, Krishnan, Sudhir, Duggal, Abhijit, Houltham, Stuart, Graf, Jerónimo, Diaz, Roderigo, Orrego, Roderigo, Delgado, Camila, González, Joyce, Sanchez, Maria Soledad, Piagnerelli, Michael, Sarrazin, Josefa Valenzuela, Zabert, Prof. Gustavo, Espinosa, Lucio, Delgado, Paulo, Delgado, Victoria, Rincón, Diego Fernando Bautista, Yanten, Angela Maria Marulanda, Duque, Melissa Bustamante, Brodie, Daniel, Abouelmagd, Khaled, Elhazmi, Alyaa, Al-Hudaib, Abdullah, Javidfar, Jeff, Callahan, Maria, Dong, Andy, D'Orleans, Charles Crepy, Taufik, M. Azhari, Wardoyo, Elizabeth Yasmin, Gunawan, Margaretha, Trisnaningrum, Nurindah S, Irawany, Vera, Rayhan, Muhammad, Panigada, Mauro, Pesenti, Antonio, Zanella, Alberto, Grasselli, Giacomo, Colombo, Sebastiano, Martinet, Chiara, Florio, Gaetano, Antonelli, Massimo, Carelli, Simone, Grieco, Domenico L., Asaki, Motohiro, Hoshino, Kota, Salazar, Leonardo, Monsalve, Mary Alejandra Mendoza, Laffey, John, McNicholas, Bairbre, Cosgrave, David, Atif, Minha, Qutishat, Fadi, Laffey, Caoimhe, Van Der Walt, Michaeal, McCaffrey, Joseph, Bone, Allison, Trickey, Jemma, Horton, Michelle, Pearce, Stephanie, Salerno, Tania, Mohamed, Akram, Alhaddad, Salem, Bakeer, Baliad, Haitam, Shames, Shalabi, Laila, Ahmed, Mohammed Abodina, Hakeem, Yusuff, Winearls, James, Tallott, Mandy, Thomson, David, Joubert, Ivan, Arnold-Day, Christel, Piercy, Jenna, Smit, Richard van Zyl, Miller, Malcom, Seymour, Lisa, van Heyningen, Francois, Teyangesikayi, Gilbert, Fredericks, David, Hssain, Ali Ait, Aliudin, Jeffrey, Alqahtani, Al-Reem, Mohamed, Khoulod, Mohamed, Ahmed, Tan, Darwin, Villanueva, Joy, Zaqout, Ahmed, Labib, Ahmed, Kurtzman, Ethan, Ademi, Arben, Dobrita, Ana, Aoudi, Khadija El, Segura, Juliet, Giwangkancana, Gezy, Ohshimo, Shinichiro, Osatnik, Javier, Joosten, Anne, Torres, Antoni, Yang, Minlan, Motos, Ana, Luna, Carlos, Arancibia, Francisco, Williams, Virginie, Noel, Alexandre, Luque, Nestor, Fantini, Marina, García, Ruth Noemi Jorge, Alvarez, Enrique Chicote, Greti, Anna, Ceccato, Adrian, Sanchez, Angel, Vazquez, Ana Loza, Roche-Campo, Ferran, Franch-Llasat, Diego, Tuazon, Divina, Amato, Marcelo, Cassimiro, Luciana, Pola, Flavio, Ribeiro, Francis, Fonseca, Guilherme, Dalton, Heidi, Desai, Mehul, Osborn, Erik, Deeb, Hala, Arcadipane, Antonio, Martucci, Gennaro, Panarello, Giovanna, Vitiello, Stefano, Bianco, Claudia, Occhipinti, Giovanna, Rossetti, Matteo, Cuffaro, Raffaele, Siddig, Nidhal, Cho, Sung-Min, Whitman, Glenn, Sayed, Marwan El, Mokhtar, Walaa, El-Shenawy, Eslam, Shimizu, Hiroaki, Moriyama, Naoki, Kim, Jae-Burm, Kitamura, Nobuya, Gebauer, Johannes, Yokoyama, Toshiki, Al-Fares, Abdulrahman, Buabbas, Sarah, Alamad, Esam, Alawadhi, Fatma, Alawadi, Kalthoum, Khalefa, Mohamed Ahmed, Ajeel, Nourah Ahmad Abdulaziz Al, Aly, Mohammad Fathy, Al-Saleh, Abdullah, Naanouh, Abdullah, Elshourbgy, Alaa Mohammed, Gad, Mohamed Yousef, ElRazaz, Rania Mohamed, Khadadah, Ibrahim, Almumin, Ahmed Mohammed, Altarakma, Hala, Albannay, Hasan, Alsaleh, Mohammed Kh, Radwan, Mahmoud Saad Abdallah, Saadallah, Islam Ahmed, Tanaka, Hiro, Hashimoto, Satoru, Yamazaki, Masaki, Oh, Tak-Hyuck, Epler, Mark, Forney, Cathleen, Kruse, Louise, Feister, Jared, Williamson, Joelle, Grobengieser, Katherine, Gnall, Eric, Golden, Sasha, Caroline, Mara, Shapiro, Timothy, Karaj, Colleen, Thome, Lisa, Sher, Lynn, Vanderland, Mark, Welch, Mary, McDermott, Sherry, Brain, Matthew, Mineall, Sarah, Unwin, Maria, Chen, Lixian, Trezise, Tarnya, McKeon, Laurie, Kimura, Dai, Brazzi, Luca, Sales, Gabriele, Montrucchio, Giorgia, Ogston, Tawnya, Nagpal, Dave, Fischer, Karlee, Lorusso, Roberto, van Bussell, Bas, De Piero, Maria Elena, Mariani, Silvia, Rangappa, Dr Rajavardhan, Shetty, Dr Rajesh Mohan, P, Sujin Rai, Ganesan, Argin, Tharwat, Samar, Esperatti, Mariano, Fuentes, Nora Angélica, Gonzalez, Maria Eugenia, Carton, Edmund G., Sen, Ayan, Palacios, Amanda, Rainey, Deborah, Samoukoviv, Gordan, Campisi, Josie, Durham, Lucia, Neumann, Emily, Seefeldt, Cassandra, Falcucci, Octavio, Emmrich, Amanda, Guy, Jennifer, Johns, Carling, Potzner, Kelly, Zimmermann, Catherine, Espinal, Angelia, Buchtele, Nina, Schwameis, Michael, Korhnfehl, Andrea, Brock, Roman, Staudinger, Thomas, Stecher, Stephanie-Susanne, Barnikel, Michaela, Antón, Sófia, Pawlikowski, Alexandra, Zaaqoq, Akram, Galloway, Lan Anh, Merley, Caitlin, Muftah, Mohamed, Nichol, Alistair, Csete, Marc, Quesada, Luisa, Saba, Isabela, Kasugai, Daisuke, Hiraiwa, Hiroaki, Tanaka, Taku, Marwali, Eva, Purnama, Yoel, Dewayanti, Santi Rahayu, Ardiyan, Juzar, Dafsah Arifa, Siagian, Debby, Chen, Yih-Sharng, Aldhalia, Amer, Ogino, Mark, Nasa, Prashant, Matthew, Christina, Majeed, Nimisha Abdul, Hafez, Wael, Ratsep, Indrek, Post, Andra-Maris, Sillaots, Piret, Krund, Anneli, Lehiste, Merili-Helen, Lepik, Tanel, Manetta, Frank, Mihelis, Effe, Sarmiento, Iam Claire, Narasimhan, Mangala, Varrone, Michael, Komats, Mamoru, Garcia-Diaz, Julia, Harmon, Catherine, Satyapriya, S. Veena, Bhatt, Amar, Mokadam, Nahush A., Uribe, Alberto, Gonzalez, Alicia, Shi, Haixia, McKeown, Johnny, Pasek, Joshua, Fiorda, Juan, Echeverria, Marco, Moreno, Rita, Zakhary, Bishoy, Cavana, Marco, Cucino, Alberto, Foti, Giuseppe, Giani, Marco, Fumagalli, Benedetta, Chiumello, Davide, Castagna, Valentina, Dell'Amore, Andrea, Navalesi, Paolo, Shum, Hoi-Ping, Vuysteke, Alain, Usman, Asad, Acker, Andrew, Smood, Benjamin, Mergler, Blake, Sertic, Federico, Subramanian, Madhu, Sperry, Alexandra, Rizer, Nicolas, Burhan, Erlina, Rasmin, Menaldi, Akmal, Ernita, Sitompul, Faya, Lolong, Navy, Naivedh, Bhat, Erickson, Simon, Barrett, Peter, Dean, David, Daugherty, Julia, Loforte, Antonio, Khan, Irfan, Quraishi, Mohammed Abraar, DeSantis, Olivia, Nasrallah, Ahmad, So, Dominic, Kandamby, Darshana, Mandei, Jose M., Natanael, Hans, YudhaLantang, Eka, Lantang, Anastasia, Wijaya, Surya Oto, Jung, Anna, Ng, George, Ng, Wing Yiu, Ng, Pauline Yeung, Fang, Shu, Tabah, Alexis, Ratcliffe, Megan, Duroux, Maree, Alajeeli, Ahmed, Tarhabat, Ali, Adachi, Shingo, Nakao, Shota, Blanco, Pablo, Prieto, Ana, Sánchez, Jesús, Nicholson, Meghan, Butt, Warwick, Serratore, Alyssa, Delzoppo, Carmel, Janin, Pierre, Yarad, Elizabeth, Totaro, Richard, Coles, Jennifer, Pujo, Bambang, Balk, Robert, Vissing, Andy, Kapania, Esha, Hays, James, Fox, Samuel, Yantosh, Garrett, Mishin, Pavel, Adem, Safia, Yuliarto, Saptadi, Santoso, Kohar Hari, Djajalaksana, Susanthy, Fatoni, Arie Zainul, Fukuda, Masahiro, Liu, Keibun, Pelosi, Paolo, Battaglini, Denise, Robba, Chiara, Jiménez, Juan Fernando Masa, Bastos, Diego, Gaião, Sérgio, Rusmawatiningtyas, Desy, Cho, Young-Jae, Lee, Su Hwan, Kawasaki, Tatsuya, Munshi, Laveena, Sakiyalak, Pranya, Nitayavardhana, Prompak, Elagili, Mohamed Bashir, Salem, Talat Ahmed Abu, Seitz, Tamara, Arora, Rakesh, Kent, David, Marino, Daniel, Parwar, Swapnil, Cheng, Andrew, Miller, Jennene, Fujitani, Shigeki, Shimizu, Naoki, Madhok, Jai, Owyang, Clark, Buscher, Hergen, Reynolds, Claire, Abdurraouf, Abusalama, Kredan, Ali Abdulnasir, Haddud, Abdurrahman, Moharam, Saad, Maasikas, Olavi, Beljantsev, Aleksan, Mihnovits, Vladislav, Akimoto, Takako, Aizawa, Mariko, Horibe, Kanako, Onodera, Ryota, Hodgson, Carol, Burrell, Aidan, Young, Meredith, George, Timothy, Shekar, Kiran, McGuinness, Niki, Irvine, Lacey, Flynn, Brigid, Almjersah, Abdulrahman, Bakri, Ashraf, Endo, Tomoyuki, Sugiyama, Kazuhiro, Shimizu, Keiki, Fan, Eddy, Exconde, Kathleen, Ichiba, Shingo, Binnawara, Muhannud, Embarek, Hussein, Lussier, Leslie, Lotz, Gösta, Malfertheiner, Maximilian, Maier, Lars, Dreier, Esther, Kusumastuti, Neurinda Permata, McCloskey, Colin, Dabaliz, Al-Awwab, Elshazly, Tarek B, Smith, Josiah, Szuldrzynski, Konstanty S., Bielański, Piotr, Wille, Keith, Murthy, Srinivas, Parhar, Ken Kuljit S., Fiest, Kirsten M., Codan, Cassidy, Shahid, Anmol, Fayed, Mohamed, Evans, Timothy, Garcia, Rebekah, Gutierrez, Ashley, Song, Tae, Rose, Rebecca, Bennett, Suzanne, Richardson, Denise, Peek, Giles, 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McBride, Angela, Negaard, Kathryn, Ratsch, Angela, Abdelaziz, Ahmad, Uribe, Juan David, Peris, Adriano, Sanders, Mark, Emerson, Dominic, Kamal, Muhammad, Faida, Hamza, Povoa, Pedro, Francis, Roland, Cherif, Ali, Joseph, Sunimol, Nardo, Matteo Di, Heard, Micheal, Kyle, Kimberly, Blackwell, Ray A, OUYAHIA, Amel, Biston, Patrick, Jeong, Hye Won, Smith, Reanna, Prawira, Yogi, Garcia, Arturo Huerta, Salterain, Nahikari, Meyns, Bart, Elnasser, Muhammed, Moreno, Marsha, Walia, Rajat, Mehta, Amit, Schweda, Annette, Williams, Melissa, Amkhatirah, Emad, Kim, Kyung Hoon, Assad, Alexandra, Giraldo, Estefania, Karolak, Wojtek, Balik, Martin, Pocock, Elizabeth, Gajkowski, Evan, Bedair, Mohamed, Masafumi, Kanamoto, Barrett, Nicholas, Takeyama, Yoshihiro, Park, Sunghoon, Amin, Faizan, Andriyani, Fina Meilyana, Sudakevych, Serhii, Schnur, Janos, Vera, Magdalena, Cornejo, Rodrigo, Schwarz, Patrícia, Mardini, Ana Carolina, de Paula, Thais, Neto, Ary Serpa, Villoldo, Andrea, Colafranceschi, Alexandre Siciliano, Iglesias, Alejandro Ubeda, Granjean, Juan, Melro, Lívia Maria Garcia, Romualdo, Giovana Fioravante, Gaia, Diego, Souza, Helmgton, Galas, Filomena, Mendiluce, Rafael Máñez, Sosa, Alejandra, Martinez, Ignacio, Kurosawa, Hiroshi, Almoshantaf, Mohammad Badr, Salgado, Juan, Hugi-Mayr, Beate, Charbonneau, Eric, Barzilai, Vitor Salvatore, Monteiro, Veronica, de Souza, Rodrigo Ribeiro, Harper, Michael, Suzuki, Hiroyuki, Adams, Celina, Brieva, Jorge, Khamees, Almu'atasim, Graige, Fadi, Supriatna, Moh, Nyale, George, Eltatar, Faisal Saleem, Fatani, Jihan, Baeissa, Husam, Masri, Ayman AL, Rabie, Ahmed, Hui, Mok Yee, Yamane, Masahiro, Jung, Hanna, Margaret, Ayorinde Mojisola, Nacpil, Newell, Ruck, Katja, Bakken, Rhonda, Jara, Claire, Felton, Tim, Berra, Lorenzo, Shah, Bobby, Chakraborty, Arpan, Cardona, Monika, Capatos, Gerry, Akkanti, Bindu, Orija, Abiodun, Jain, Harsh, Ito, Asami, Housni, Brahim, Low, Sennen, Iihara, Koji, Chavez, Joselito, Ramanathan, Kollengode, Zabert, Gustavo, Naidoo, Krubin, Seppelt, Ian, VanDyk, Marlice, MacDonald, Sarah, McGregor, Randy, Siebenaler, Teka, Flynn, Hannah, Lofton, Kristi, Aokage, Toshiyuki, Kvirkvelia, Bakar, Shigemitsu, Kazuaki, Moscatelli, Andrea, Fiorentino, Giuseppe, Baumgaertel, Matthias, Mba, Serge Eddy, Assy, Jana, Hutahaean, Amelya, Roush, Holly, Sichting, Kay A, Alessandri, Francesco, Burns, Debra, Alkhubouli, Taha Husayn, Salt, Gavin, Garabedian, Carl P., Millar, Jonathan, Sim, Malcolm, Mattke, Adrian, McAuley, Danny, Tadili, Jawad, Frenzel, Tim, Abuleil, Amro, Bar-Lavie, Yaron, Ortiz, Aaron Blandino, Stone, Jackie, Attokaran, Antony, Farquharson, Michael, Patel, Brij, Gunning, Derek, Baillie, Kenneth, Watson, Pia, Tamai, Kenji, Saaid, Ayoub, Anania, Pasquale, Sajinadiyasa, Gede Ketut, Kanyawati, Dyah, Salgado, Marcello, Sassine, Assad, Yudo, Bhirowo, McCaul, Scott, Lee, Bongjin, Lee, Sang Min, Afek, Arnon, Fattouh, Shimaa E, Iwashita, Yoshiaki, Fadlalmola, Hammad, Semedi, Bambang Pujo, Mansour, Noureldin Mohamed, Metiva, Jack, Van Belle, Nicole, Martin-Loeches, Ignacio, Al-Sadawi, Dr Mohammed, Kirakli, Cenk, Shimaa, Al-Touny, Ivatt, Lenny, Woon, Chia Yew, Kang, Hyun Mi, Smith, Timothy, James, Erskine, Al-Rawas, Nawar, Iwasaki, Yudai, Ashour, Hamza, King-Chung, Kenny Chan, Gudzenko, Vadim, Taccone, Fabio, Perdhana, Fajar, Lamarche, Yoan, Ribeiro, Joao Miguel, Bradic, Nikola, Van den Bossche, Klaartje, Lansink, Oude, Singh, Gurmeet, Debeuckelaere, Gerdy, Stelfox, Henry T., Yi, Cassia, Elia, Jennifer, Tribble, Thomas, Shankar, Shyam, Padmanabhan, Raj, Hallinan, Bill, Paoletti, Luca, Leyva, Yolanda, Fykuda, Tatuma, Badulak, Jenelle, Koch, Jillian, Janowaik, Lisa, Hackman, Amy, Hernandez, Deb, Osofsky, Jennifer, Donadello, Katia, Lawang, Aizah, Fine, Josh, Davidson, Benjamin, Vazquez, Andres Oswaldo Razo, Abdehaleem, Ibrahim, Kelly, Thu-Lan, Fanning, Jonathon, Premraj, Lavienraj, Porto, Diego Bastos, White, Nicole M., Bassi, Gianluigi Li, Suen, Jacky, and Fraser, John F.

Published
2024
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23. Safety, pharmacokinetics, and pharmacodynamics of nomlabofusp (CTI‐1601) in Friedreich's ataxia

Author

Russell Clayton, Teresa Galas, Noreen Scherer, Jennifer Farmer, Nancy Ruiz, Mohamed Hamdani, Devin Schecter, and David Bettoun

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Objective Current treatments for Friedreich's ataxia, a neurodegenerative disorder characterized by decreased intramitochondrial frataxin, do not address low frataxin concentrations. Nomlabofusp (previously CTI‐1601) is a frataxin replacement therapy with a unique mechanism of action that directly addresses this underlying frataxin deficiency. Phase 1 studies assessed the safety, pharmacokinetic, and pharmacodynamic profiles of subcutaneously administered nomlabofusp in adults with Friedreich's ataxia. Methods Patients were enrolled in two Phase 1, double‐blind, placebo‐controlled studies. The single ascending‐dose (SAD) study (NCT04176991) evaluated single doses of nomlabofusp (25, 50, 75, or 100 mg) or placebo. The multiple ascending‐dose (MAD) study (NCT04519567) evaluated nomlabofusp (25 mg daily for 4 days then every third day, 50 mg daily for 7 days then every 2 days, or 100 mg daily) or placebo for 13 days. Results Patients aged 19–69 years were enrolled (SAD, N = 28; MAD, N = 27). Nomlabofusp was generally well tolerated through 13 days. Most adverse events were mild and resolved quickly. No serious adverse events or deaths were reported. Peak nomlabofusp plasma concentrations occurred 15 min after subcutaneous administration. Nomlabofusp plasma exposures increased with increasing doses and daily administration and decreased with reduced dosing frequency. Increased frataxin concentrations were observed in buccal cells, skin, and platelets with higher and more frequent nomlabofusp administration. Interpretation Results from this study support a favorable safety profile for nomlabofusp. Subcutaneous nomlabofusp injections were quickly absorbed; higher doses and daily administration resulted in increased tissue frataxin concentrations. Future studies will evaluate longer‐term safety and possible efficacy of nomlabofusp.

Published
2024
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24. Challenges and success stories of the implementation of infection control and antimicrobial stewardship strategies: proceedings of the 5th Global Ministerial Summit on Patient Safety, 2023

Author

Andrea C. Büchler, Murielle Haddad Galas, Niccolò Buetti, Emine Alp, Anucha Apisarnthanarak, Gerald Dziekan, Valeria Fabre, Simon Gottwalt, Kazuaki Jindai, Babacar Ndoye, Hilda Márquez Villareal, Fernando Otaiza, Didier Pittet, Natalie Schellack, Céline Gardiol, and Stephan Harbarth

Subjects
Infection control, Antibiotic stewardship, Antimicrobial resistance, Health plan implementation, Global ministerial summit on patient safety, Infectious and parasitic diseases, RC109-216
Abstract

Abstract The 5th edition of the Global Ministerial Summit on Patient Safety was held in Montreux, Switzerland, in February 2023, delayed by three years due to the COVID-19 pandemic. The overarching theme of the summit was “Less Harm, Better Care – from Resolution to Implementation”, focusing on the challenges of implementation of infection prevention and control (IPC) strategies as well as antimicrobial stewardship programs (ASP) around the world. IPC strategies and ASP are of increasing importance due to the substantial burden of healthcare-associated infections and antimicrobial resistance threatening patient safety. Here, we summarize countries’ and regional experiences and activities related to the implementation of IPC strategies and ASP shared at the meeting. Full implementation of effective programs remains a major challenge in all settings due to limited support by political and healthcare leaders, and human and financial constraints. In addition, the COVID-19 pandemic challenged already well-established programs. By enforcing sustained implementation by dedicated, cross-disciplinary healthcare personnel with a broad skill set, a reduction in healthcare-associated infections and multidrug-resistant pathogens can be achieved, leading ultimately to improved patient safety.

Published
2024
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25. Phase 2 of extracellular RNA communication consortium charts next-generation approaches for extracellular RNA research

Author

Mateescu, Bogdan, Jones, Jennifer C, Alexander, Roger P, Alsop, Eric, An, Ji Yeong, Asghari, Mohammad, Boomgarden, Alex, Bouchareychas, Laura, Cayota, Alfonso, Chang, Hsueh-Chia, Charest, Al, Chiu, Daniel T, Coffey, Robert J, Das, Saumya, De Hoff, Peter, deMello, Andrew, D’Souza-Schorey, Crislyn, Elashoff, David, Eliato, Kiarash R, Franklin, Jeffrey L, Galas, David J, Gerstein, Mark B, Ghiran, Ionita H, Go, David B, Gould, Stephen, Grogan, Tristan R, Higginbotham, James N, Hladik, Florian, Huang, Tony Jun, Huo, Xiaoye, Hutchins, Elizabeth, Jeppesen, Dennis K, Jovanovic-Talisman, Tijana, Kim, Betty YS, Kim, Sung, Kim, Kyoung-Mee, Kim, Yong, Kitchen, Robert R, Knouse, Vaughan, LaPlante, Emily L, Lebrilla, Carlito B, Lee, L James, Lennon, Kathleen M, Li, Guoping, Li, Feng, Li, Tieyi, Liu, Tao, Liu, Zirui, Maddox, Adam L, McCarthy, Kyle, Meechoovet, Bessie, Maniya, Nalin, Meng, Yingchao, Milosavljevic, Aleksandar, Min, Byoung-Hoon, Morey, Amber, Ng, Martin, Nolan, John, De Oliveira, Getulio P, Paulaitis, Michael E, Phu, Tuan Anh, Raffai, Robert L, Reátegui, Eduardo, Roth, Matthew E, Routenberg, David A, Rozowsky, Joel, Rufo, Joseph, Senapati, Satyajyoti, Shachar, Sigal, Sharma, Himani, Sood, Anil K, Stavrakis, Stavros, Stürchler, Alessandra, Tewari, Muneesh, Tosar, Juan P, Tucker-Schwartz, Alexander K, Turchinovich, Andrey, Valkov, Nedyalka, Van Keuren-Jensen, Kendall, Vickers, Kasey C, Vojtech, Lucia, Vreeland, Wyatt N, Wang, Ceming, Wang, Kai, Wang, ZeYu, Welsh, Joshua A, Witwer, Kenneth W, Wong, David TW, Xia, Jianping, Xie, Ya-Hong, Yang, Kaichun, Zaborowski, Mikołaj P, Zhang, Chenguang, Zhang, Qin, Zivkovic, Angela M, and Laurent, Louise C

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Biochemistry, Biological sciences, Cell biology, Molecular biology
Abstract

The extracellular RNA communication consortium (ERCC) is an NIH-funded program aiming to promote the development of new technologies, resources, and knowledge about exRNAs and their carriers. After Phase 1 (2013-2018), Phase 2 of the program (ERCC2, 2019-2023) aims to fill critical gaps in knowledge and technology to enable rigorous and reproducible methods for separation and characterization of both bulk populations of exRNA carriers and single EVs. ERCC2 investigators are also developing new bioinformatic pipelines to promote data integration through the exRNA atlas database. ERCC2 has established several Working Groups (Resource Sharing, Reagent Development, Data Analysis and Coordination, Technology Development, nomenclature, and Scientific Outreach) to promote collaboration between ERCC2 members and the broader scientific community. We expect that ERCC2's current and future achievements will significantly improve our understanding of exRNA biology and the development of accurate and efficient exRNA-based diagnostic, prognostic, and theranostic biomarker assays.

Published
2022

26. Crosslinking and depletion determine spatial instabilities in cytoskeletal active matter

Author

Sarfati, Guillaume, Maitra, Ananyo, Voituriez, Raphael, Galas, Jean-Christophe, and Estevez-Torres, André

Subjects
Condensed Matter - Soft Condensed Matter, Physics - Biological Physics
Abstract

Active gels made of cytoskeletal proteins are valuable materials with attractive non-equilibrium properties such as spatial self-organization and self-propulsion. At least four typical routes to spatial patterning have been reported to date in different types of cytoskeletal active gels: bending and buckling instabilities in extensile systems, and global and local contraction instabilities in contractile gels. Here we report the observation of these four instabilities in a single type of active gel and we show that they are controlled by two parameters: the concentrations of ATP and depletion agent. We demonstrate that as the ATP concentration decreases, the concentration of passive motors increases until the gel undergoes a gelation transition. At this point, buckling is selected against bending, while global contraction is favored over local ones. Our observations are coherent with a hydrodynamic model of a viscoelastic active gel where the filaments are crosslinked with a characteristic time that diverges as the ATP concentration decreases. Our work thus provides a unified view of spatial instabilities in cytoskeletal active matter.

Published
2021

28. The Heritage Hunt

Author

Kelly Banyas, Marleen Cloutier, and Jennifer Galas

Subjects
Library orientation, Library programming, First-year experience, Scavenger hunts, Student engagement, Bibliography. Library science. Information resources
Abstract

In his 2013 article, Professor George Aulisio introduced the Weinberg Memorial Library’s Heritage Hunt, an interactive scavenger hunt designed to introduce first-year students to the library. Ten years later, the Heritage Hunt program still plays a critical role in library orientation at the University of Scranton. In this article, the authors discuss changes made in collaboration with multiple library departments to transform and ultimately improve the Heritage Hunt. The article will describe the adaptations made to the orientation program as it has evolved and will also share insights into how to expand the program to broaden its reach to students beyond their first year.

Published
2024
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29. Marcadores de Perfusão Tecidual como Preditores de Desfechos Adversos em Pacientes com Disfunção Ventricular Esquerda Submetidos à Revascularização Miocárdica (Bypass Coronário)

Author

Thiana Yamaguti, José Otavio Costa Auler Junior, Luís Alberto Oliveira Dallan, Filomena Regina Barbosa Gomes Galas, Ligia Cristina Câmara Cunha, and Marilde de Albuquerque Piccioni

Subjects
Cirurgia Torácica, Disfunção Ventricular Esquerda, Biomarcadores, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Resumo Fundamento: Pacientes submetidos à cirurgia cardíaca podem estar expostos à hipoperfusão tecidual e metabolismo anaeróbico. Objetivo: Verificar se os biomarcadores de hipoperfusão tecidual têm valor preditivo para permanência prolongada na Unidade de Terapia Intensiva (UTI) em pacientes com disfunção ventricular esquerda submetidos à cirurgia de bypass da artéria coronária. Métodos: Após aprovação pelo comitê de ética institucional e assinatura do termo de consentimento, 87 pacientes com disfunção ventricular esquerda (fração de ejeção

Published
2024
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30. Co-operation of MCL-1 and BCL-XL anti-apoptotic proteins in stromal protection of MM cells from carfilzomib mediated cytotoxicity

Author

Daria Galas-Filipowicz, Selina J. Chavda, Jia-Nan Gong, David C. S. Huang, Asim Khwaja, and Kwee Yong

Subjects
carfilzomib, drug resistance, stromal cells, anti-apoptotic proteins, Mcl-1, BCL-XL, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

IntroductionBCL-2 family proteins are important for tumour cell survival and drug resistance in multiple myeloma (MM). Although proteasome inhibitors are effective anti-myeloma drugs, some patients are resistant and almost all eventually relapse. We examined the function of BCL-2 family proteins in stromal-mediated resistance to carfilzomib-induced cytotoxicity in MM cells.MethodsCo-cultures employing HS5 stromal cells were used to model the interaction with stroma. MM cells were exposed to CFZ in a 1-hour pulse method. The expression of BCL-2 family proteins was assessed by flow cytometry and WB. Pro-survival proteins: MCL-1, BCL-2 and BCL-XL were inhibited using S63845, ABT-199 and A-1331852 respectively. Changes in BIM binding partners were examined by immunoprecipitation and WB.ResultsCFZ induced dose-dependent cell death of MM cells, primarily mediated by apoptosis. Culture of MM cells on HS-5 stromal cells resulted in reduced cytotoxicity to CFZ in a cell contact-dependent manner, upregulated expression of MCL-1 and increased dependency on BCL-XL. Inhibiting BCL-XL or MCL-1 with BH-3 mimetics abrogated stromal-mediated protection only at high doses, which may not be achievable in vivo. However, combining BH-3 mimetics at sub-therapeutic doses, which alone were without effect, significantly enhanced CFZ-mediated cytotoxicity even in the presence of stroma. Furthermore, MCL-1 inhibition led to enhanced binding between BCL-XL and BIM, while blocking BCL-XL increased MCL-1/BIM complex formation, indicating the cooperative role of these proteins.ConclusionStromal interactions alter the dependence on BCL-2 family members, providing a rationale for dual inhibition to abrogate the protective effect of stroma and restore sensitivity to CFZ.

Published
2024
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32. Palaeolakes, caves and settlement during the Pleistocene and Holocene around Tsakhiurtyn Hundi, Mongolia

Author

Masojc, Miroslaw, Gunchinsuren, Byambaa, Szykulski, Jozef, Michalec, Grzegorz, Dashzeveg, Bazargur, Sikora, Rafal, Odsuren, Davaakhuu, Bobrowski, Przemyslaw, Jordeczka, Maciej, Wojcik, Antoni, Galas, Andrzej, Szmit, Marcin, Gankhuyag, Odpurev, Osypihska, Marta, Namjilmaa, Enkhtaivan, and David, Eva

Subjects
Hunting and gathering societies, Caves -- Discovery and exploration
Abstract

The authors present results from a new research project focusing on the prehistory of the area surrounding a vast flint outcrop in Mongolia, called Tsakhiurtyn Hundi, in the borderland between the Gobi-Altai Mountains and Gobi Desert. They present the discovery of a cave and the results of its exploration, confirming its use by Pleistocene hunter-gatherers. Keywords: Mongolia, Palaeolithic, palaeoenvironment, Khutul Usny Cave, Tsakhiurtyn Hundi, Introduction Tsakhiurtyn Hundi (Flint Valley), located about 700km south of Ulaanbaatar (the capital of Mongolia), is one of the most extensive prehistoric sites of Central Asia (Figure 1A & B). […]

Published
2024
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34. ML-Based Maintenance and Control Process Analysis, Simulation, and Automation—A Review

Author

Izabela Rojek, Dariusz Mikołajewski, Ewa Dostatni, Adrianna Piszcz, and Krzysztof Galas

Subjects
machine learning, deep learning, Industry 4.0, Industry 5.0, control, signal classification, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999
Abstract

Automation and digitalization in various industries towards the Industry 4.0/5.0 paradigms are rapidly progressing thanks to the use of sensors, Industrial Internet of Things (IIoT), and advanced fifth generation (5G) and sixth generation (6G) mobile networks supported by simulation and automation of processes using artificial intelligence (AI) and machine learning (ML). Ensuring the continuity of operations under different conditions is becoming a key factor. One of the most frequently requested solutions is currently predictive maintenance, i.e., the simulation and automation of maintenance processes based on ML. This article aims to extract the main trends in the area of ML-based predictive maintenance present in studies and publications, critically evaluate and compare them, and define priorities for their research and development based on our own experience and a literature review. We provide examples of how BCI-controlled predictive maintenance due to brain–computer interfaces (BCIs) play a transformative role in AI-based predictive maintenance, enabling direct human interaction with complex systems.

Published
2024
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35. A Reflected-Light-Mode Multiwavelength Interferometer for Measurement of Step Height Standards

Author

Dariusz Litwin, Kamil Radziak, Adam Czyżewski, Jacek Galas, Tadeusz Kryszczyński, Narcyz Błocki, Robert Szumski, and Justyna Niedziela

Subjects
interferometry, variable wavelength interferometry, multiwavelength interferometer, waveplate, refractive index, Wollaston prism, Chemical technology, TP1-1185
Abstract

The article is dedicated to measuring the thickness of step height standards using the author’s version of the variable wavelength interferometer (VAWI) in the reflected-light mode, where the interference pattern is created by the combination of two Wollaston prisms. The element of novelty consists in replacing the traditional search for the coincidence of fringes in the object and background with a continuous measurement of their periods and phases relative to the zero-order fringe. The resulting system of sinusoids is then analyzed using two methods: the classical one and the second utilizing the criterion of uniform thickness. The theory is followed by simulation and experimental parts, providing insight to the metrological potential of the VAWI technology.

Published
2024
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36. Influence of Oleacein, an Olive Oil and Olive Mill Wastewater Phenolic Compound, on Caenorhabditis elegans Longevity and Stress Resistance

Author

Morgane Carrara, Myriam Richaud, Pierre Cuq, Simon Galas, and Delphine Margout-Jantac

Subjects
oleacein, C. elegans, aging, olive oil, olive mill wastewater, Chemical technology, TP1-1185
Abstract

Oleacein, a bioactive compound of olive oil and olive mill wastewater, has one of the strongest antioxidant activities among olive phenolics. However, few reports explore the in vivo antioxidant activity of oleacein, with no clear identification of the biological pathway involved. Earlier studies have demonstrated a link between stress resistance, such as oxidative stress, and longevity. This study presents the effects of oleacein on Caenorhabditis elegans mean lifespan and stress resistance. A significant lifespan extension was observed with an increase of 20% mean lifespan at 5 µg/mL with a hormetic-like dose-dependent effect. DAF-16 and SIR-2.1 were involved in the effects of oleacein on the longevity of C. elegans, while the DAF-2 receptor was not involved. This study also shows the capacity of oleacein to significantly enhance C. elegans resistance to oxidative and thermal stress and allows a better understanding of the positive effects of olive phenolics on health.

Published
2024
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37. Digitalizing Teaching and Learning in Light of Sustainability in Times of the Post-Covid-19 Period: Challenges, Issues, and Opportunities

Author

Larsari, Vahid Norouzi, Wildová, Radka, Dhuli, Raju, Chenari, Hossein, Reyes-Chua, Ethel, Galas, Elbert M., Sario, Jay A., Lanuza, Maryann H., Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Motahhir, Saad, editor, and Bossoufi, Badre, editor

Published
2023
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38. The Role of Galanin in Cerebellar Granule Cell Migration in the Early Postnatal Mouse during Normal Development and After Injury

Author

Komuro, Yutaro, Galas, Ludovic, Morozov, Yury M, Fahrion, Jennifer K, Raoult, Emilie, Lebon, Alexis, Tilot, Amanda K, Kikuchi, Shin, Ohno, Nobuhiko, Vaudry, David, Rakic, Pasko, and Komuro, Hitoshi

Subjects
Biomedical and Clinical Sciences, Neurosciences, Stem Cell Research - Nonembryonic - Non-Human, Stem Cell Research, Physical Injury - Accidents and Adverse Effects, Neurodegenerative, 2.1 Biological and endogenous factors, Aetiology, Neurological, Animals, Animals, Newborn, Brain, Brain Injuries, Cell Movement, Cells, Cultured, Cerebellum, Dose-Response Relationship, Drug, Female, Galanin, Male, Mice, cerebellum, galanin, granule cell, live cell imaging, mice, neuronal migration, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery
Abstract

Galanin, one of the most inducible neuropeptides, is widely present in developing brains, and its expression is altered by pathologic events (e.g., epilepsy, ischemia, and axotomy). The roles of galanin in brain development under both normal and pathologic conditions have been hypothesized, but the question of how galanin is involved in fetal and early postnatal brain development remains largely unanswered. In this study, using granule cell migration in the cerebellum of early postnatal mice (both sexes) as a model system, we examined the role of galanin in neuronal cell migration during normal development and after brain injury. Here we show that, during normal development, endogenous galanin participates in accelerating granule cell migration via altering the Ca2+ and cAMP signaling pathways. Upon brain injury induced by the application of cold insults, galanin levels decrease at the lesion sites, but increase in the surroundings of lesion sites. Granule cells exhibit the following corresponding changes in migration: (1) slowing down migration at the lesion sites; and (2) accelerating migration in the surroundings of lesion sites. Experimental manipulations of galanin signaling reduce the lesion site-specific changes in granule cell migration, indicating that galanin plays a role in such deficits in neuronal cell migration. The present study suggests that manipulating galanin signaling may be a potential therapeutic target for acutely injured brains during development.SIGNIFICANCE STATEMENT Deficits in neuronal cell migration caused by brain injury result in abnormal development of cortical layers, but the underlying mechanisms remain to be determined. Here, we report that on brain injury, endogenous levels of galanin, a neuropeptide, are altered in a lesion site-specific manner, decreasing at the lesion sites but increasing in the surroundings of lesion sites. The changes in galanin levels positively correlate with the migration rate of immature neurons. Manipulations of galanin signaling ameliorate the effects of injury on neuronal migration and cortical layer development. These results shed a light on galanin as a potential therapeutic target for acutely injured brains during development.

Published
2021

41. Reliability of Accuracy and Precision Tests for Elite Para Table Tennis Players.

Author

Galas, Szymon, Andrzejewski, Marcin, and Pluta, Beata

Subjects
*MEDICAL protocols, *WHEELCHAIRS, *DATA analysis, *CRONBACH'S alpha, *SPORTS for people with disabilities, *TENNIS, *KRUSKAL-Wallis Test, *RACKET games, *DESCRIPTIVE statistics, *INTELLECTUAL disabilities, *STATISTICAL reliability, *FRIEDMAN test (Statistics), *STATISTICS, *CONCEPTUAL structures, *NATIONAL competency-based educational tests, *POLISH people, *RELIABILITY (Personality trait), *NONPARAMETRIC statistics, *EVALUATION, RESEARCH evaluation
Abstract

The primary purpose of this study was to adapt selected accuracy and precision tests in table tennis to the specific skills of elite table tennis players with impairment. The study included a sample of 23 Para table tennis players with an average age of 31.8 ± 12.22 years (including 30.4% females) who belonged to the senior Polish Para table tennis team. A battery of six tests evaluating stroke accuracy and serve precision was assessed. The analysis of the reliability of these tests confirmed the legitimacy of using this battery of accuracy and precision tests to assess the skills of Para table tennis players in all three integrated sport classes: players in wheelchairs, in a standing position, and with intellectual impairment. Analysis of the data obtained from the tests could provide coaches with relevant information regarding elite Para table tennis players' level of performance and examine selected accuracy and precision elements of their individual technique. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Dipalmitoyl-phosphatidylserine-filled cationic maltodextrin nanoparticles exhibit enhanced efficacy for cell entry and intracellular protein delivery in phagocytic THP-1 cells

Author

Brinkhuizen Clément, Shapman Damien, Lebon Alexis, Bénard Magalie, Tardivel Meryem, Dubuquoy Laurent, Galas Ludovic, and Carpentier Rodolphe

Subjects
nanoparticle, vaccine, phospholipids, efferocytosis, targeting, Biology (General), QH301-705.5
Abstract

Vaccination through the upper respiratory tract is a promising strategy, and particulate antigens, such as antigens associated with nanoparticles, triggered a stronger immune response than the sole antigens. Cationic maltodextrin-based nanoparticles loaded with phosphatidylglycerol (NPPG) are efficient for intranasal vaccination but non-specific to trigger immune cells. Here we focused on phosphatidylserine (PS) receptors, specifically expressed by immune cells including macrophages, to improve nanoparticle targeting through an efferocytosis-like mechanism. Consequently, the lipids associated with NPPG have been substituted by PS to generate cationic maltodextrin-based nanoparticles with dipalmitoyl-phosphatidylserine (NPPS). Both NPPS and NPPG exhibited similar physical characteristics and intracellular distribution in THP-1 macrophages. NPPS cell entry was faster and higher (two times more) than NPPG. Surprisingly, competition of PS receptors with phospho-L-serine did not alter NPPS cell entry and annexin V did not preferentially interact with NPPS. Although the protein association is similar, NPPS delivered more proteins than NPPG in cells. On the contrary, the proportion of mobile nanoparticles (50%), the movement speed of nanoparticles (3 µm/5 min), and protein degradation kinetics in THP-1 were not affected by lipid substitution. Together, the results indicate that NPPS enter cells and deliver protein better than NPPG, suggesting that modification of the lipids of cationic maltodextrin-based nanoparticles may be a useful strategy to enhance nanoparticle efficacy for mucosal vaccination.

Published
2023
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44. Women’s experience of perinatal support in a high migrant Australian population during the COVID-19 pandemic: a mixed methods study

Author

Sarah J. Melov, Nelma Galas, Julie Swain, Thushari I. Alahakoon, Vincent Lee, N Wah Cheung, Therese McGee, Dharmintra Pasupathy, and Justin McNab

Subjects
COVID-19, Pandemics, Maternity care, Migrants, Social Support, Antenatal Care, Gynecology and obstetrics, RG1-991
Abstract

Abstract Background As a COVID-19 risk mitigation measure, Australia closed its international borders for two years with significant socioeconomic disruption including impacting approximately 30% of the Australian population who are migrants. Migrant populations during the peripartum often rely on overseas relatives visiting for social support. High quality social support is known to lead to improved health outcomes with disruption to support a recognised health risk. Aim To explore women’s experience of peripartum social support during the COVID-19 pandemic in a high migrant population. To quantify type and frequency of support to identify characteristics of vulnerable perinatal populations for future pandemic preparedness. Methods A mixed methods study with semi-structured interviews and a quantitative survey was conducted from October 2020 to April 2021. A thematic approach was used for analysis. Results There were 24 participants interviewed both antenatally and postnatally (22 antenatal; 18 postnatal). Fourteen women were migrants and 10 Australian born. Main themes included; ‘Significant disruption and loss of peripartum support during the COVID-19 pandemic and ongoing impact for migrant women’; ‘Husbands/partners filling the support gap’ and ‘Holding on by a virtual thread’. Half of the participants felt unsupported antenatally. For Australian born women, this dissipated postnatally, but migrants continued to feel unsupported. Migrant women discussed partners stepped into traditional roles and duties of absent mothers and mothers-in-law who were only available virtually. Conclusion This study identified disrupted social support for migrant women during the pandemic, providing further evidence that the pandemic has disproportionately impacted migrant populations. However, the benefits identified in this study included high use of virtual support, which could be leveraged for improving clinical care in the present and in future pandemics. The COVID-19 pandemic impacted most women’s peripartum social support with migrant families having ongoing disruption. Gains in the pandemic included greater gender equity for domestic work as husbands/partners increased their contribution to domestic work and childcare.

Published
2023
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50. The Group Theoretic Roots of Information: permutations, symmetry, and entropy

Author

Galas, David J.

Subjects
Computer Science - Information Theory
Abstract

We propose a new interpretation of measures of information and disorder by connecting these concepts to group theory in a new way. Entropy and group theory are connected here by their common relation to sets of permutations. A combinatorial measure of information and disorder is proposed, in terms of integers and discrete functions, that we call the integer entropy. The Shannon measure of information is the limiting case of a richer, more general conceptual structure that reveals relations among finite groups, information, and symmetries. It is shown that the integer entropy converges uniformly to the Shannon entropy when the group includes all permutations, the Symmetric group, and the number of objects increases without bound. The harmonic numbers have a well-known combinatorial meaning as the expected number of disjoint, non-empty cycles in permutations of n objects, and since integer entropy is defined in terms of the expected value of the number of cycles over the set of permutations, it also has a clear combinatorial meaning. Since all finite groups are isomorphic to subgroups of the Symmetric group, every finite group has a corresponding information functional, analogous to the Shannon entropy and a number series analogous to the harmonic numbers. The Cameron-Semeraro cycle polynomial is used to analyze the integer entropy for finite groups, and to characterize the series analogous to the Harmonic numbers. We introduce and use a reciprocal polynomial, the transposition polynomial that provides an additional tool and new insights. Broken symmetries and conserved quantities are linked through the cycle and transposition properties of the groups, and can be used to generalize the analysis of stochastic processes., Comment: This revised manuscript has 37 pages, a few small corrections and clarifications, an added section and an added appendix

Published
2019

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