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10. CoreView: Fresh Tissue Biopsy Assessment at the Bedside Using a Millifluidic Imaging Chip

Author

Matthew D. Carson, David Cooper, Farzad Fereidouni, Suzanne M. Dintzis, Eric J. Seibel, Mark E. Fauver, Huang C, Klavins D, and Galambos C

Subjects
Core needle, medicine.medical_specialty, Diagnostic information, medicine.diagnostic_test, business.industry, Chip, Fluid transport, Fresh Tissue, Biopsy, medicine, Histopathology, Intact tissue, business, Biomedical engineering
Abstract

Minimally invasive core needle biopsies for medical diagnoses have become increasingly common for many diseases. Although tissue cores can yield more diagnostic information than fine needle biopsies and cytologic evaluation, there is no rapid evaluation at the point-of-care for intact tissue cores that is low-cost and non-destructive to the biopsy. We have developed a proof-of-concept 3D printed millifluidic histopathology lab-on-a-chip device to automatically handle, process, and image fresh core needle biopsies. This device, named CoreView, includes modules for biopsy removal from the acquisition tool, transport, staining and rinsing, imaging, segmentation, and multiplexed storage. Reliable removal from side-cutting needles and bidirectional fluid transport of core needle biopsies from five tissue types has been demonstrated with 0.5-mm positioning accuracy. Automation is aided by a MATLAB-based biopsy tracking algorithm that can detect the location of tissue and air bubbles in the channels of the millifluidic chip. With current and emerging optical imaging technologies, CoreView can be used for a rapid adequacy test at the point-of-care for tissue identification and glomeruli counting from renal core needle biopsies, and has the potential to be used for breast cancer diagnosis, phenotyping, and mapping of enriched tumorous regions for downstream analyses in global health applications.

Published
2021
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24. Synchrotron Phase Contrast Micro-CT as a Novel Tool for Understanding Pulmonary Vascular Pathobiology and the 3D Micro-Anatomy of Alveolar Capillary Dysplasia with Misaligned Pulmonary Veins

Author

Tran-Lundmark, K., primary, Westöö, C., additional, Norvik, C., additional, Peruzzi, N., additional, Lovric, G., additional, van der Have, O., additional, Mokso, R., additional, Jeremiasen, I., additional, Brunnström, H., additional, Galambos, C., additional, and Bech, M., additional

Published
2019
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39. Cation distribution in mammalian red blood cells: interspecies and intraspecies relationships between cellular ATP, potassium, sodium and magnesium concentrations

Author

Wheatley, D. N., Attila Miseta, Kellermayer, M., Galambos, C., Bogner, P., Berènyi, E., and Cameron, I. L.

Subjects
Erythrocytes, Sheep, Swine, Deer, Goats, Sodium, In Vitro Techniques, Rats, Adenosine Triphosphate, Dogs, Species Specificity, Cations, Cricetinae, Potassium, Animals, Humans, Cattle, Magnesium, Horses
Abstract

The intracellular K+/Na+ ratio of erythrocytes of different mammalian species are known to differ markedly. These differences are sustained despite plasma potassium and sodium concentrations being almost identical, i.e. high [Na+] and low [K+], in all mammalian species. Conventional cell theory couples intracellular K+ and Na+ concentrations with Na+/K(+)-dependent ATPase activity. Ling's Association-Induction (AI) hypothesis couples intracellular K+ and Na+ concentrations with the concentration of ATP, by way of an inductive adsorption of both monovalent cations on the available terminal and lateral carboxyl groups of proteins. Based on the working hypothesis, different relationships are expected between the erythrocyte K+ and Na+ concentrations and ATP levels. Our results indicate that the intracellular ATP level in erythrocytes of different species corresponds with intracellular K+ and Na+ levels, K+/Na+ ratios and total K+ + Na+ levels. Similar relationships were revealed between the erythrocyte ATP and monovalent cation contents of different individual sheep.

Published
1994

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