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Your search keyword '"Galaburda, A.M."' showing total 23 results
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23 results on '"Galaburda, A.M."'

1. Human cerebral cortex: localization, parcellation, and morphometry with magnetic resonance imaging

Author

Rademacher, J., Galaburda, A.M., Kennedy, D.N., Filipek, P.A., and Caviness, V.S., Jr.

Subjects
Brain -- Magnetic resonance imaging, Brain mapping -- Research, Cerebral cortex -- Research, Health, Psychology and mental health
Abstract

A system of parcellation of the human brain based on the functional anatomy of the cerebral cortex was mapped by magnetic resonance imaging. This system is designed to investigate hemisphere asymmetries and quantitative lesion localization studies in neuroscience. The boundaries are determined by 'limiting fissures' and completed by a set of coronal planes which 'close' the border of the parcellation system.

Published
1992

19. Behavior, Cortical Ectopias, and Autoimmunity in BXSB-Yaa and BXSB-Yaa+ Mice

Author

Schrott, L.M., Waters, N.S., Boehm, G.W., Sherman, G.F., Morrison, L., Rosen, G.D., Behan, P.O., Galaburda, A.M., and Denenberg, V.H.

Abstract

The BXSB­Yaa recombinant inbred strain was created by crossing a male SB/Le with a female C57BL/6J. A Y chromosome factor derived from the SB/Le male, known as the autoimmune accelerator (Yaa), leads to an earlier onset and greater severity of autoimmune disease in males. In contrast, male BXSB mice, which lack the Yaa gene (called BXSB­Yaa+) because their Y chromosome is derived from the C57BL/6J, do not develop an autoimmune condition. To examine the influence of the Y chromosome on behavior, cortical ectopia incidence, and immune functioning, males and females of these two strains were compared. Significant strain differences (for both sexes) were found for behavioral measures including discrimination, spatial and avoidance learning, and activity. For immunological parameters, a sex difference was seen in the BXSB­Yaa (males more autoimmune), but not in the BXSB­Yaa+ strain. As expected, male BXSB­Yaas were more autoimmune than male BXSB­Yaa + s. However, there was also a strain difference for IgG in the females (BXSB­Yaa+ greater). No strain difference was found for the presence of ectopias. However, there was a sex difference across both strains, with males having a higher incidence. BXSB­Yaa and BXSB­Yaa+ mice have behavioral and immunological differences greater than would be predicted by their known genetic differences. The significant differences between the two female groups suggest that the two strains differ with respect to autosomal genes, in addition to the Y chromosome. The incidence of ectopias is independent of this genetic difference and is influenced by the subject"s sex.Copyright 1993, 1999 Academic Press

Published
1993
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