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BACKGROUND: Data on long-term neurodevelopmental outcomes of normocephalic children (born with normal head circumference) exposed to Zika virus in utero are scarce. We aimed to compare neurodevelopmental outcomes in normocephalic children up to age 48 months with and without Zika virus exposure in utero. METHODS: In this prospective cohort study, we included infants from two cohorts of normocephalic children born in León and Managua, Nicaragua during the 2016 Zika epidemic. In León, all women pregnant during the two enrolment periods were eligible. In Managua, mother-child pairs were included from three districts in the municipality of Managua: all women who became pregnant before June 15, 2016, and had a due date of Sept 15, 2016 or later were eligible. Infants were serologically classified as Zika virus-exposed or Zika virus-unexposed in utero and were followed up prospectively until age 48 months. At 36 months and 48 months of age, the Mullen Scales of Early Learning (MSEL) assessment was administered. Primary outcomes were MSEL early learning composite (ELC) scores at 30-48 months in León and 36-48 months in Managua. We used an inverse probability weighting generalised estimating equations model to assess the effect of Zika virus exposure on individual MSEL cognitive domain scores and ELC scores, adjusted for maternal education and age, poverty status, and infant sex. FINDINGS: The initial enrolment period for the León cohort was between Jan 31 and April 5, 2017 and the second was between Aug 30, 2017, and Feb 22, 2018. The enrolment period for the Managua cohort was between Oct 24, 2019, and May 5, 2020. 478 mothers (482 infants) from the León cohort and 615 mothers (609 infants) from the Managua cohort were enrolled, of whom 622 children (303 from the León cohort; 319 from the Managua cohort) were included in the final analysis; four children had microcephaly at birth and thus were excluded from analyses, two from each cohort. 33 (11%) of 303 children enrolled in León and 219 (69%) of 319 children enrolled in Managua were exposed to Zika virus in utero. In both cohorts, no significant differences were identified in adjusted mean ELC scores between Zika virus-exposed and unexposed infants at 36 months (between-group difference 1·2 points [95% CI -4·2 to 6·5] in the León cohort; 2·8 [-2·4 to 8·1] in the Managua cohort) or at 48 months (-0·9 [-10·8 to 8·8] in the León cohort; 0·1 [-5·1 to 5·2] in the Managua cohort). No differences in ELC scores between Zika virus-exposed and unexposed infants exceeded 6 points at any time between 30 months and 48 months in León or between 36 months and 48 months in Managua, which was considered clinically significant in other settings. INTERPRETATION: We found no significant differences in neurodevelopmental scores between normocephalic children with in-utero Zika virus exposure and Zika virus-unexposed children at age 36 months or 48 months. These findings are promising, supporting typical neurodevelopment in Zika virus-exposed normocephalic children, although additional follow-up and research is warranted. FUNDING: National Institute of Child Health and Development, National Institute of Allergy and Infectious Diseases, and Fogarty International Center. TRANSLATION: For the Spanish translation of the abstract see Supplementary Materials section.

This work presents the results of a four-year study on the determination of the range of soil groundwater drainage caused by the operation of the Tomisławice lignite open-cast mine. The performed analyses covered the area of 9600 ha which included 24 villages. It was found that operation of Tomisławice open-cast mine caused noticeable changes of soil groundwater level in the areas adjacent to the excavation. It consequently resulted in considerable changes in soil water regimes types on grassland areas but it did not always lead to soil degradation processes. However, the deterioration of soils hydrological conditions may cause disappearance of certain hydrophilous grass species.

The aim of the study was the assessment of the influence of EM-A preparation on the properties of soil structure of medium and fine texture. Soil material for the incubation experiment was collected from humus arable horizons of four mineral soils: Gleyic Chernozem (soils A, B and D) and Haplic Fluvisol (soil C). The experiment was conducted in containers of 2000 cm3, where soil material of about 3 kg was placed and three doses of EM-A were added. After a 12-month incubation, aggregates of 1 cm3 were cut out. Their basic physical properties (density, porosity) were determined, as well as the parameters which characterize the structure: dynamic and static water resistance, secondary aggregation after dynamic and static water resistance and capillary water capacity. The effect of additions of EM-A was not significant for majority of analyzed soil properties.

The paper presents the advanced control system of the wind energy conversion with a variable speed wind turbine. The considered system consists of a wind turbine with the permanent magnet synchronous generator (PMSG), machine side converter (MSC), grid side converter (GSC) and control circuits. The mathematical models of a wind turbine system, the PMSG generator and converters have been described. The control algorithms of the converter systems based on the methods of vector control have been applied. In the advanced control system of the machine side converter the optimal MPPT control method has been used. Additionally the pitch control scheme is included in order to achieve the limitation of maximum power and to prevent mechanical damage of the wind turbine. In the control system of the grid side converter the control of active and reactive power has been applied with the application of Voltage Oriented Control (VOC). The performance of the considered wind energy system has been studied by digital simulation. The results of simulation studies confirmed the good effectiveness of the considered wind turbine system and very good performance of the proposed methods of vector control and control systems.

Abstract The article presents the accessibility conditions for carrying out research work for an exemplary site in the southern Baltic Sea region. The basic parameter of the state of the marine environment was the significant wave height determined at a frequency of one hour based on the ERA 5 model data covering the period between 1940 and 2022. A statistical analysis of the variability of this height on a monthly basis, taking into account its conversion into the time of potential availability in conditions enabling research, showed its strong seasonal variability in the form of differences in the number of hours that can be used for operating purposes. This number, depending on the research vessel capabilities, may even be an order of magnitude higher in the summer months than in winter. Additionally, it was found that the variability of the significant wave height has not changed substantially over the last 82 years.

Abstract Obstructive sleep apnea (OSA) is characterized by co-occurrence with affective disorders. Our study aims to investigate the association of circadian clock gene expressions, and the presence and severity of depressive symptoms in OSA patients. The study included 184 individuals, who underwent polysomnography (PSG) and had their peripheral blood collected in the evening before and the morning after the PSG. Patients were divided into two groups: the OSA (apnea-hypopnea index (AHI) > 5) and the control group (AHI

Thin-walled structures that serve as energy absorbers are widely used in the automotive industry, and it is well-known that they deform in a specific way under dynamic loading, forming plastic hinges along the yield line. The dynamic impact of these structures causes various phenomena that affect the formation of folds and, consequently, the dynamic response of the structure. The force-shortening curve, which is based on the unified crush efficiency indicators, is a key factor in determining the dynamic response of the structure. While there have been many studies on energy absorbers under static or quasi-static loading conditions, the effect of changing kinetic energy components (mass and velocity) on the obtained crush efficiency indicators is not as well understood. This article presents the results of experimental tests and nonlinear numerical simulations for eleven different initial conditions of the crashworthiness analysis. The tests showed a significant effect of changing the velocity and mass of the striker on the results obtained. Additionally, the nonlinear effect of the change in the velocity of the tup with respect to the peak force and total efficiency was demonstrated.

Abstract This dataset consists of 64-channels resting-state EEG recordings of 608 participants aged between 20 and 70 years, 61.8% female, as well as follow-up measurements after approximately 5 years of 208 participants, starting 2021. The EEG was measured for three minutes with eyes open and eyes closed before and after a 2-hour block of cognitive experimental tasks. The data set is part of the Dortmund Vital Study, a prospective study on the determinants of healthy cognitive aging. The dataset can be used for (1) analyzing cross-sectional resting-state EEG of healthy individuals across the adult life span; (2) generating normalization data sets for comparison of resting-state EEG data of patients with clinically relevant disorders; (3) studying effects of performing cognitive tasks on resting-state EEG and age; (4) exploring intra-individual changes in resting-state EEG and effects of task performance over a time period of about 5 years. The data are provided in Brain Imaging Data Structure (BIDS) format and are available on OpenNeuro.

Understanding the effect of long-term drainage of peatland areas is helpful in future peatland management and regulations of water conditions. The aim of this work was to assess the current state of fen peatland soils in the Grójecka Valley (eastern part of the Wielkopolskie voivodeship, central Poland), affected by long-term agricultural use (pastures, meadows) since the 1960s and potentially by lignite open pit mining industry (KWB Konin) since 1980s. Field studies were carried out in 2015 in selected fen peatland areas. Soil material for laboratory analysis was collected from genetic horizons from four soil profiles. The surface horizons of studied organic and organo-mineral soils were built with well-developed moorsh material. They were classified as medium moorshiefied – MtII (profile 1, 3 and 4) and strongly moorshiefied – MtIII (profile 2). Obtained results of physical and physico-chemical analysis indicate that long-term peatland utilization connected with potential impact of the lignite mining, transformed mainly the upper horizons of studied organic and organo-mineral soils. However, despite obvious strong human impact on peatlands ecosystems, we cannot exclude the climate variables, what should be confirmed by long-term monitoring program. Furthermore, presented paper indicated that new subtype moorsh-muddy soils (in Polish: gleby murszowo-mułowe) within the type of gleyic soils should be implemented in the next version of Polish Soil Classification.

Gender-fair language makes women and people of other genders, their interests, and achievements more visible. However, critics argue that gender-fair language impairs the comprehensibility and aesthetic appeal of texts. This study tests these assumptions specifically concerning the gender asterisk, a form of gender-fair language that makes people outside the male-female dichotomy typographically more visible in German. In two experiments with N = 133 and N = 110, subjects were randomly given one of three versions of a text, either with masculine-only forms (e.g. die "Spieler*innen," ~"the fe*male players"), the gender asterisk in its plural form (e.g. "die Spieler*innen," "the fe*male players"), or the gender asterisk in its singular form (e.g. "der*die Spieler*in," "the*the fe*male player"). Subsequently, participants completed a comprehensibility questionnaire. Both experiments show that the gender asterisk in its singular form impairs comprehensibility, but only Experiment 1 shows an impairment due to its plural form.

The paper presents the characteristics of selected physical, chemical, and water properties of four mineral arable soils characterized with heavy and very heavy texture. Soil samples from genetic horizons of black earths from areas near Kętrzyn, Gniew and Kujawy, and alluvial soils from Żuławy were used. The following properties were determined in the samples of undisturbed and disturbed structure: texture, particle density, bulk density, porosity, natural and hygroscopic moistures, maximal hygroscopic capacity, saturated hydraulic conductivity, potential of water bonding in soil, total and readily available water, total retention in the horizon of 0–50 cm, drainage porosity, content of organic carbon and total nitrogen Parent rocks of these soils were clays, silts and loams of various origin. High content of clay fraction strongly influenced the values of all the analyzed properties. All the examined soils had high content of organic carbon and total nitrogen and reaction close to neutral or alkaline. High content of mineral and organic colloids and, what follows, beneficial state of top horizons’ structure, determined – apart from heavy texture – low soil bulk density and high porosity. The investigated soils were characterized by high field water capacity and wide scopes of total and readily available water. The saturated hydraulic conductivity was low and characteristic to heavy mineral arable soils. The parameter which influenced the variability of analyzed parameters most was texture.

The paper presents physical and water properties of six soils located in the areas directly adjacent to “Drzewce” lignite open cast mine (KWB Konin). The conducted works included preparation of pits of various soil types in points characteristic to large and representative soil allotments. The selected soil types represented mineral and organic soils. Samples of disturbed and undisturbed structure were taken from various genetic horizons for laboratory analysis. Such properties as content of total carbon, texture, specific density, bulk density, total and drainage porosity, moisture, saturated hydraulic conductivity, the potential of water bonding, total and readily available water, and total retention were determined in the samples from the horizons of 0–100 cm. The investigated soils showed mostly sandy texture with few local loam insertions. Texture and the content of organic matter were the most important parameters which influenced all analyzed properties. Morphology and the properties of the examined soils as well as deep level of soil – ground water were decisive factors when categorizing them as a precipitation-water type. Such soils will not undergo degradation caused by the dehydrating depression cone of open cast mine.

The rapid rollout of vaccinations in response to the COVID-19 pandemic has led to their widespread distribution and administration throughout the world. The benefit of these vaccinations in preventing the spread of the disease and diminishing symptoms in patients who contract COVID-19 has been fervently studied and reported. While vaccinations remain an effective and generally safe method of limiting disease transmission and virus-related mortality, vaccine administration is not completely without risk. Shoulder injuries related to vaccine administration (SIRVA) have been described with previously available vaccines but have yet to be widely reported in the COVID-19 vaccination population. We present a case report of a young, high-functioning patient who presented with acute subacromial bursitis after COVID-19 vaccine administration due to improper vaccination technique. The patient was treated with arthroscopic shoulder surgery and had near immediate relief of shoulder symptoms.

The two cases presented demonstrate the management of aneurysmal bone cysts of the metacarpal, which destroyed the normal bone architecture. Treatment of both cases included wide resection and metacarpal reconstruction with an intercalary fibular allograft. Denosumab use contrasts these two cases and is helpful in reestablishment of a cortical rim for fixation in the absence of a 1-cm margin proximally or distally to preserve the native carpometacarpal and metacarpophalangeal joints. Surgical resection and allograft reconstruction is a viable treatment for expansile metacarpal aneurysmal bone cysts, and neoadjuvant denosumab has utility in creating an ossified margin for fixation.

Esports and high-performance human-computer interaction are at the forefront of implementing new hardware and software technologies Despite that, there is a paucity of research on how championship-level esports professionals approach aspects of their preparation.

Distinguishing between web traffic generated by bots and humans is an important task in the evaluation of online marketing campaigns. One of the main challenges is related to only partial availability of the performance metrics: although some users can be unambiguously classified as bots, the correct label is uncertain in many cases. This calls for the use of classifiers capable of explaining their decisions. This paper demonstrates two such mechanisms based on features carefully engineered from web logs. The first is a man-made rule-based system. The second is a hierarchical model that first performs clustering and next classification using human-centred, interpretable methods. The stability of the proposed methods is analyzed and a minimal set of features that convey the class-discriminating information is selected. The proposed data processing and analysis methodology are successfully applied to real-world data sets from online publishers.

Abstract The Oklahoma City bombing in 1995 was one of the most devastating incidents of terrorism in America at that time. Existing research has not examined changes in emotional responses outside of psychopathology to disaster over time. The sample for this study consisted of adult participants randomly selected from a state registry of survivors who were directly exposed to the 1995 bombing in Oklahoma City. The Disaster Supplement to the Diagnostic Interview Schedule was used to collect participants’ demographic information and qualitative details of their disaster experience, perceptions, and feelings. A total of 315 items resulted from the coding of responses pertaining to emotions (125 immediately after the disaster event, 140 in the following week, and 50 at approximately seven years postdisaster). The most common emotions in the immediate postdisaster period were shock, fear, and anxiety. In the following week, the most common were sorrow and anger. At seven years, sorrow was the most frequently expressed of all emotions. Understanding the progression of these feelings across time enhances the ability to anticipate responses at different postdisaster timeframes and to intervene in a timely manner.

Abstract Heart failure (HF) poses a significant challenge, often leading to frequent hospitalizations and compromised quality of life. Continuous pulmonary artery pressure (PAP) monitoring offers a surrogate for congestion status in ambulatory HF care. This meta-analysis examines the efficacy of PAP monitoring devices (CardioMEMS and Chronicle) in preventing adverse outcomes in HF patients, addressing gaps in prior randomized controlled trials (RCTs). Five RCTs (2572 participants) were systematically reviewed. PAP monitoring significantly reduced HF-related hospitalizations (RR 0.72 [95% CI 0.6–0.87], p = 0.0006) and HF events (RR 0.86 [95% CI 0.75–0.99], p = 0.03), with no impact on all-cause or cardiovascular mortality. Subgroup analyses highlighted the significance of CardioMEMS and blinded studies. Meta-regression indicated a correlation between prolonged follow-up and increased reduction in HF hospitalizations. The risk of bias was generally high, with evidence certainty ranging from low to moderate. PAP monitoring devices exhibit promise in diminishing HF hospitalizations and events, especially in CardioMEMS and blinded studies. However, their influence on mortality remains inconclusive. Further research, considering diverse patient populations and intervention strategies with extended follow-up, is crucial for elucidating the optimal role of PAP monitoring in HF management.

Abstract The very shallow marine basin of Puck Lagoon in the southern Baltic Sea, on the Northern coast of Poland, hosts valuable benthic habitats and cultural heritage sites. These include, among others, protected Zostera marina meadows, one of the Baltic’s major medieval harbours, a ship graveyard, and likely other submerged features that are yet to be discovered. Prior to this project, no comprehensive high-resolution remote sensing data were available for this area. This article describes the first Digital Elevation Models (DEMs) derived from a combination of airborne bathymetric LiDAR, multibeam echosounder, airborne photogrammetry and satellite imagery. These datasets also include multibeam echosounder backscatter and LiDAR intensity, allowing determination of the character and properties of the seafloor. Combined, these datasets are a vital resource for assessing and understanding seafloor morphology, benthic habitats, cultural heritage, and submerged landscapes. Given the significance of Puck Lagoon’s hydrographical, ecological, geological, and archaeological environs, the high-resolution bathymetry, acquired by our project, can provide the foundation for sustainable management and informed decision-making for this area of interest.

Background Individuals with a loss-of-function single-nucleotide polymorphism in the gene encoding PTPN22 have an increased risk for autoimmune diseases, and patients with cancer with such alleles may respond better to checkpoint blockade immunotherapy. Studies in PTPN22 knockout (KO) mice have established it as a negative regulator of T cell responses in cancer models. However, the role of PTPN22 in distinct immune cell compartments, such as dendritic cells (DCs), remains undefined.Methods We developed a novel PTPN22 conditional KO (cKO) mouse model that enables specific deletion in CD11c+ DCs by crossing to CD11c-Cre transgenic mice. Antitumor immunity was characterized using the B16.SIY and MC38.SIY cancer models and immune profiles of relevant tissues were evaluated by spectral flow cytometry. Antigen uptake, processing, and presentation, as well as DC proliferation to Flt3L, were characterized ex vivo.Results Deletion of PTPN22 in DCs resulted in augmented antitumor immunity in multiple syngeneic tumor models. Tumor antigen-specific CD8+ T cells were increased in the tumor microenvironment (TME) of PTPN22 cKO mice and improved tumor control was CD8+ T cell-dependent. Augmented T cell priming was also detected at early time points in the draining lymph nodes, and these effects were correlated with an increased number of proliferating CD103+ DCs, also seen in the TME. In vitro studies revealed increased DC proliferation in response to Flt3L, as well as increased antigen processing and presentation. PTPN22 cKO mice bearing MC38 parental tumors showed combinatorial benefit with anti-PD-L1 therapy.Conclusions Deletion of PTPN22 in DCs is sufficient to drive an augmented tumor antigen-specific T cell response, resulting in enhanced tumor control. PTPN22 negatively regulates DC proliferation and antigen processing and presentation. Our work argues that PTPN22 is an attractive therapeutic target for cancer immunotherapy and highlights the potential to modulate antitumor immunity through the manipulation of DC signaling.