1. Age-dependent genetic variants associated with longitudinal changes in brain structure across the lifespan
- Author
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Philip R. Jansen, Erlend Bøen, Erin Burke Quinlan, Javier Vázquez-Bourgon, Celso Arango, Sonja M C de Zwarte, Andrea Parolin Jackowski, Mohammad Arfan Ikram, Dennis van der Meer, Clara Alloza, Matthew S. Panizzon, Ryan L. Muetzel, Vidar M. Steen, Lars T. Westlye, Joanna Bright, Walter Heindel, Marcella Rietschel, Wei Wen, Frauke Nees, Daniel Keeser, Sintia Iole Belangero, Philip Shaw, Tiago Reis Marques, Neda Jahanshad, Jiyang Jiang, Benedicto Crespo Facorro, Tilo Kircher, David Ames, Dan J. Stein, Ulrik Fredrik Malt, Axel Krug, Kang Sim, Gaia Bonfiglio, Nhat Trung Doan, Katrin Amunts, John B.J. Kwok, Pedro Mario Pan, Udo Dannlowski, Markus M. Nöthen, Elena Shumskaya, Simon R. Cox, Sarah J. Heany, Perminder S. Sachdev, Aad van der Lugt, Mark E. Bastin, Brenda W.J.H. Penninx, Catherine Morgan, Elizabeth E.L. Buimer, Henrik Walter, Dara M. Cannon, Hugo G. Schnack, Sarah Hohmann, Evangelos Vassos, Shun Takahashi, Gloria Roberts, Simone Ciufolini, Loes M. Olde Loohuis, Penny A. Gowland, Joost Janssen, Michael N. Smolka, Temmuz Karali, Robin M. Murray, Herve Lemaitre, Karen A. Mather, Dennis van 't Ent, Derek W. Morris, William S. Kremen, Peter Falkai, Berend Malchow, Tim Hahn, Dag Alnæs, Ronny Redlich, Ingrid Agartz, Fabian Streit, João P.O.F.T. Guimarães, Nils Opel, Bernhard T. Baune, Marie-Laure Paillère Martinot, Catharina A. Hartman, Alexander Teumer, Frederike Stein, André Zugman, Nikita Setiaman, Jalmar Teeuw, Isabella A. Breukelaar, Vicente Medel, Stephanie H. Witt, Christienne G. Damatac, Nicolas Crossley, Luise Poustka, Hieab H.H. Adams, Linda Ding, Jonathan Repple, Jacqueline Hoare, Eric Artiges, Manon H.J. Hillegers, Andreas Heinz, Susanne Meinert, Tianye Jia, Diana Tordesillas-Gutiérrez, Marieke Klein, Herta Flor, Joanna M. Wardlaw, Roel A. Ophoff, Rodrigo A. Bressan, Antoine Grigis, Marcos L. Santoro, Javier González-Peñas, Thomas Espeseth, Torbjørn Elvsåshagen, Kristel R. van Eijk, Hilleke E. Hulshoff Pol, Sophia I. Thomopoulos, Gustavo Sudre, Juliane H. Fröhner, Rhoshel K. Lenroot, Bernd Ittermann, René S. Kahn, Gareth J. Barker, Wiepke Cahn, Yuri Milaneschi, Margaret J. Wright, Janita Bralten, Gail Davies, Elisabet Blok, Janice M. Fullerton, Jouke-Jan Hottenga, Paola Dazzan, Andreas J. Forstner, Leila Nabulsi, Christopher D. Whelan, Katharina Wittfeld, Mathew A. Harris, Julian N. Trollor, Mayuresh S. Korgaonkar, Igor Nenadic, Nitin Gogtay, Laura K.M. Han, Robin Bülow, Moji Aghajani, Leonard H. van den Berg, Marta Di Forti, Bronwyn Overs, Paul M. Thompson, Rick M. Tankard, Sven Cichon, Jason L. Stein, Jaap Oosterlaan, Jan K. Buitelaar, Jean-Luc Martinot, René C.W. Mandl, Victor Ortiz-García de la Foz, Robert Whelan, Svenja Caspers, Rosa Ayesa-Arriola, Sylvane Desrivières, Covadonga M. Díaz-Caneja, Ole A. Andreassen, Gunter Schumann, Arun L.W. Bokde, Alyssa H. Zhu, Henk-Jan Westeneng, Emma Sprooten, Sergi Papiol, Giovanni Abrahão Salum, Neeltje E.M. van Haren, Simon E. Fisher, Dominik Grotegerd, Casper L. de Mol, Alzheimer’s Disease Neuroimaging Initiative, Dorret I. Boomsma, Gennady V. Roshchupkin, Pieter J. Hoekstra, Andreas Jansen, Peter R. Schofield, Tonya White, Maria J. Knol, Rachel M. Brouwer, Martijn G.J.C. Koevoets, Thomas W. Mühleisen, Katharina Dohm, Barbara Franke, Philip B. Mitchell, Colm McDonald, Anbupalam Thalamuthu, Henry Brodaty, Gary Donohoe, Stephanie Le Hellard, Shareefa Dalvie, Georg Homuth, Jan H. Veldink, Nicola J. Armstrong, Christiane Jockwitz, Sarah E. Medland, Katrina L. Grasby, Tobias Banaschewski, Hans J. Grabe, Hugh Garavan, Dirk J. Heslenfeld, Erik G. Jönsson, Carol E. Franz, and Janik Goltermann
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2. Zero hunger ,Apolipoprotein E ,0303 health sciences ,Brain morphometry ,Human brain ,Biology ,medicine.disease ,3. Good health ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Atrophy ,Schizophrenia ,Ageing ,medicine ,Cognitive skill ,Neuroscience ,030217 neurology & neurosurgery ,Depression (differential diagnoses) ,030304 developmental biology - Abstract
SummaryHuman brain structure changes throughout our lives. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental, and neurodegenerative diseases. Here, we identified common genetic variants that affect rates of brain growth or atrophy, in the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal MRI data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genesGPR139, DACH1andAPOEare associated with metabolic processes. We demonstrate global genetic overlap with depression, schizophrenia, cognitive functioning, insomnia, height, body mass index and smoking. Gene-set findings implicate both early brain development and neurodegenerative processes in the rates of brain changes. Identifying variants involved in structural brain changes may help to determine biological pathways underlying optimal and dysfunctional brain development and ageing.
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- 2020