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Carbon‐based nanozymes have received considerable attention due to their superior biosafety, enhanced tolerance to extreme conditions, and ease of chemical modification. However, due to limited material diversity and unconfirmed molecular structure, carbon‐based nanozymes face challenges such as relatively low enzyme activity and unclear catalytic mechanisms. The development of materials with well‐defined structures and controllable properties is crucial for promoting the rapid progress of nanozymes. Herein, 3,4,9,10‐perylenetetracarboxylic dianhydride (PD) exhibits both glucose oxidase (GOx)‐like and catalase (CAT)‐like activities, which may be due to the fact that PD possesses the features of highly conjugated structure and high electron mobility. In addition, it is demonstrated that the enzymatic activity is related to the degree of PD aggregation via the characterization of its morphology and size. Based on the excellent GOx‐like and CAT‐like activities of PD, a self‐cascade catalytic system is constructed for application in biofuel cells (BFCs). It is worth mentioning that such BFC still maintains high stability after working for 30 days. Therefore, this study expands the enzyme‐like systems and discovers that nanomaterials with highly conjugated structures and high electron mobility can mimic enzymes. Additionally, the multi‐enzyme activities are utilized to construct self‐cascade systems, which can effectively improve the performance of BFCs. [ABSTRACT FROM AUTHOR]

The present study investigated the effects of different integrated cultivation treatments on the yield, nitrogen agronomic efficiency (AEN), and growth performance of a ratoon rice system. A two-year field experiment was carried out during 2021–2022 using a randomized block design. Cultivation treatments included the farmers' practice model (control, CK), high-yield and high-efficiency model (T1), enhanced-high-yield and high-efficiency model (T2), and the no-N model (N0). The grain yield, yield components, root traits, and stubble characteristics were determined. The results showed that T2 treatment significantly increased the grain yield and AEN by 53% and 236%, respectively, compared with CK. Similarly, the stubble weight, non-structure carbohydrate contents, and the root attributes were significantly improved under T2 treatment. The correlation analysis suggested that ratoon rice yield and AEN was significantly and positively correlated with root weight (p < 0.01) and the stubble parameters including stubble weight (p < 0.01), starch content (p < 0.01), and soluble sugar content (p < 0.01). Additionally, a significant and positive correlation between root weight and stubble weight (p < 0.05) was determined in our study. Consequently, our work highlights the benefits of integrating planting density, nitrogen/water management, and other practices to achieve high AEN and grain yield of the ratoon rice by improving root trait and stubble characteristics of the main rice. [ABSTRACT FROM AUTHOR]

Background: Ovarian cancer, particularly epithelial ovarian cancer (EOC), is the leading cause of cancer-related mortality among women. Our previous study revealed that high HMGB3 levels are associated with poor prognosis and lymph node metastasis in patients with high-grade serous ovarian carcinoma; however, the role of HMGB3 in EOC proliferation and metastasis remains unknown. Methods: MTT, clonogenic, and EdU assays were used to assess cell proliferation. Transwell assays were performed to detect cell migration and invasion. Signaling pathways involved in HMGB3 function were identified by RNA sequencing (RNA-seq). MAPK/ERK signaling pathway protein levels were evaluated by western blot. Results: HMGB3 knockdown inhibited ovarian cancer cell proliferation and metastasis, whereas HMGB3 overexpression facilitated these processes. RNA-seq showed that HMGB3 participates in regulating stem cell pluripotency and the MAPK signaling pathway. We further proved that HMGB3 promotes ovarian cancer stemness, proliferation, and metastasis through activating the MAPK/ERK signaling pathway. In addition, we demonstrated that HMGB3 promotes tumor growth in a xenograft model via MAPK/ERK signaling. Conclusions: HMGB3 promotes ovarian cancer malignant phenotypes and stemness through the MAPK/ERK signaling pathway. Targeting HMGB3 is a promising strategy for ovarian cancer treatment that may improve the prognosis of women with this disease. 2qup1eeBfJMNesoTGXbg-C Video Abstract [ABSTRACT FROM AUTHOR]