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33,276 results on '"Gaffney, A"'

2. Magic City

Author

Gaffney, Austyn

Published
2021

3. Development of an uncertainty-aware equation of state for gold

Author

Yang, Lin H. and Gaffney, James A.

Subjects
Condensed Matter - Materials Science
Abstract

This study introduces a framework that employs Gaussian Processes (GPs) to develop high-fidelity equation of state (EOS) tables, essential for modeling material properties across varying temperatures and pressures. GPs offer a robust predictive modeling approach and are especially adept at handling uncertainties systematically. By integrating Error-in-Variables (EIV) into the GP model, we adeptly navigate uncertainties in both input parameters (like temperature and density) and output variables (including pressure and other thermodynamic properties). Our methodology is demonstrated using first-principles density functional theory (DFT) data for gold, observing its properties over maximum density compression (up to 100 g/cc) and extreme temperatures within the warm dense matter region (reaching 300 eV). Furthermore, we assess the resilience of our uncertainty propagation within the resultant EOS tables under various conditions, including data scarcity and the intrinsic noise of experiments and simulations.

Published
2025

4. An Asymptotic Analysis of Bivalent Monoclonal Antibody-Antigen Binding

Author

Heirene, Luke A, Byrne, Helen M, Yates, James W T, and Gaffney, Eamonn A

Subjects
Quantitative Biology - Other Quantitative Biology
Abstract

Ligand-receptor interactions are fundamental to many biological processes. For example in antibody-based immunotherapies, the dynamics of an antibody binding with its target antigen directly influence the potency and efficacy of monoclonal antibody (mAb) therapies. In this paper, we present an asymptotic analysis of an ordinary differential equation (ODE) model of bivalent antibody-antigen binding in the context of mAb cancer therapies, highlighting the added complexity associated with bivalency of the antibody. To understand what drives the complex temporal dynamics of bivalent antibody-antigen binding, we construct asymptotic approximations to the model's solutions at different timescales and antibody concentrations that are in good agreement with numerical simulations of the full model. We show how the dynamics differ between two scenarios; a region where unbound antigens are abundant, and one where the number of unbound antigens is small such that the dominant balance within the model equations changes. Of particular importance to the potency and efficacy of mAb treatments are the values of quantities such as antigen occupancy and bound antibody number. We use the results of our asymptotic analysis to approximate the long-time values of these quantities that could be combined with experimental data to facilitate parameter estimation.

Published
2025

7. A First Look at the 2021 Postsecondary Enrollment, Completion, and Financial Aid Outcomes of Fall 2009 Ninth-Graders. High School Longitudinal Study of 2009 (HSLS:09). NCES 2024-022

Author

National Center for Education Statistics (NCES) (ED/IES), American Institutes for Research (AIR), Emma Cohen, Huade Huo, Katherine Guyot, and Colleen Gaffney

Abstract

This First Look report provides selected findings from the High School Longitudinal Study of 2009 (HSLS:09) Postsecondary Education Administrative Records Collection (PEAR). HSLS:09 follows a nationally representative sample of students who were ninth-graders in fall 2009 from high school into postsecondary education and the workforce. The PEAR data collection was conducted in 2021, approximately 8 years after high school graduation for most of the cohort. These data provide information on whether fall 2009 ninth-graders enrolled in postsecondary education by June 2021, and allow researchers to examine enrollment characteristics, degree completion, and financial aid awards for the subset of fall 2009 ninth-graders who enrolled in postsecondary education.

Published
2024

8. Multiconfigurational Electronic Structure of Nickel Cross-Coupling Catalysts Revealed by X-ray Absorption Spectroscopy.

Author

Nelson, Kacie, Kazmierczak, Nathanael, Cagan, David, Follmer, Alec, Scott, Thais, Raj, Sumana, Garratt, Douglas, Powers-Riggs, Natalia, Gaffney, Kelly, Hadt, Ryan, and Cordones, Amy

Abstract

NiII 2,2-bipyridine complexes are commonly invoked intermediates in metallaphotoredox cross-coupling reactions. Despite their ubiquity, design principles targeting improved catalytic performance remain underdetermined. A series of Ni(Rbpy)(RAr)Cl (R = MeOOC, t-Bu, R = CH3, CF3) complexes were proposed to have multiconfigurational electronic structures on the basis of multiconfigurational/multireference calculations, with significant mixing of Ni → bpy metal-to-ligand charge transfer (MLCT) configurations into the ground-state wave function. Here, Ni K-edge and L2,3-edge X-ray absorption spectroscopies provide experimental support for the highly covalent and multiconfigurational electronic structures of these complexes. The pre-edge intensity in the K-edge spectrum reflects highly covalent Ni-aryl bonding. The L3-edge spectral shape is dependent on ligand functionalization, and a feature reflecting the MLCT character is assigned using prior ab initio and new semiempirical calculations. The results suggest the push/pull effects of the aryl/bpy ligands moderate the changes in electron density on Ni during the multiredox cross-coupling reaction cycle.

Published
2024

9. Physics-Informed Transformation Toward Improving the Machine-Learned NLTE Models of ICF Simulations

Author

Cho, Min Sang, Grabowski, Paul E., Thopalli, Kowshik, Jayram, Thathachar S., Barrow, Michael J., Thiagarajan, Jayaraman J., Anirudh, Rushil, Le, Hai P., Scott, Howard A., Kallman, Joshua B., Stephens, Branson C., Foord, Mark E., Gaffney, Jim A., and Bremer, Peer-Timo

Subjects
Physics - Plasma Physics, Physics - Computational Physics
Abstract

The integration of machine learning techniques into Inertial Confinement Fusion (ICF) simulations has emerged as a powerful approach for enhancing computational efficiency. By replacing the costly Non-Local Thermodynamic Equilibrium (NLTE) model with machine learning models, significant reductions in calculation time have been achieved. However, determining how to optimize machine learning-based NLTE models in order to match ICF simulation dynamics remains challenging, underscoring the need for physically relevant error metrics and strategies to enhance model accuracy with respect to these metrics. Thus, we propose novel physics-informed transformations designed to emphasize energy transport, use these transformations to establish new error metrics, and demonstrate that they yield smaller errors within reduced principal component spaces compared to conventional transformations., Comment: 10 pages, 7 figures

Published
2024

10. Persistent homology classifies parameter dependence of patterns in Turing systems

Author

Spector, Reemon, Harrington, Heather A., and Gaffney, Eamonn A.

Subjects
Quantitative Biology - Quantitative Methods, Mathematics - Algebraic Topology, 92C15, 55N31
Abstract

This paper illustrates a further application of topological data analysis to the study of self-organising models for chemical and biological systems. In particular, we investigate whether topological summaries can capture the parameter dependence of pattern topology in reaction diffusion systems, by examining the homology of sublevel sets of solutions to Turing reaction diffusion systems for a range of parameters. We demonstrate that a topological clustering algorithm can reveal how pattern topology depends on parameters, using the chlorite--iodide--malonic acid system, and the prototypical Schnakenberg system for illustration. In addition, we discuss the prospective application of such clustering, for instance in refining priors for detailed parameter estimation for self-organising systems., Comment: 24 pages, 9 figures

Published
2024

11. Pattern Localisation in Swift-Hohenberg via Slowly Varying Spatial Heterogeneity

Author

Krause, Andrew L., Klika, Václav, Villar-Sepúveda, Edgardo, Champneys, Alan R., and Gaffney, Eamonn A.

Subjects
Nonlinear Sciences - Pattern Formation and Solitons, 35B36, 35B32
Abstract

Theories of localised pattern formation are important to understand a broad range of natural patterns, but are less well-understood than more established mechanisms of domain-filling pattern formation. Here, we extend recent work on pattern localisation via slow spatial heterogeneity in reaction-diffusion systems to the Swift-Hohenberg equation. We use a WKB asymptotic approach to show that, in the limit of a large domain and slowly varying heterogeneity, conditions for Turing-type linear instability localise in a simple way, with the spatial variable playing the role of a parameter. For nonlinearities locally corresponding to supercritical bifurcations in the spatially homogeneous system, this analysis asymptotically predicts regions where patterned states are confined, which we confirm numerically. We resolve the inner region of this asymptotic approach, finding excellent agreement with the tails of these confined pattern regions. In the locally subcritical case, however, this theory is insufficient to fully predict such confined regions, and so we propose an approach based on numerical continuation of a local homogeneous analog system. Pattern localisation in the heterogeneous system can then be determined based on the Maxwell point of this system, with the spatial variable parameterizing this point. We compare this theory of localisation via spatial heterogeneity to localised patterns arising from homoclinic snaking, and suggest a way to distinguish between different localisation mechanisms in natural systems based on how these structures decay to the background state (i.e. how their tails decay). We also explore cases where both of these local theories of pattern formation fail to capture the interaction between spatial heterogeneity and underlying pattern-forming mechanisms, suggesting that more work needs to be done to fully disentangle exogenous and intrinsic heterogeneity., Comment: 36 pages, 17 figures

Published
2024

13. Composting

Author

Gaffney, Austyn

Published
2019

24. Evolution of the nuclear spin-orbit splitting explored via the $^{32}$Si($d$,$p$)$^{33}$Si reaction using SOLARIS

Author

Chen, J., Kay, B. P., Hoffman, C. R., Tang, T. L., Tolstukhin, I. A., Bazin, D., Lubna, R. S., Ayyad, Y., Beceiro-Novo, S., Coombes, B. J., Freeman, S. J., Gaffney, L. P., Garg, R., Jayatissa, H., Kuchera, A. N., MacGregor, P., Mitchell, A. J., Mittig, W., Monteagudo, B., Munoz-Ramos, A., Müller-Gatermann, C., Recchia, F., Rijal, N., Santamaria, C., Serikow, M. Z., Sharp, D. K., Smith, J., Stecenko, J. K., Wilson, G. L., Wuosmaa, A. H., Yuan, C. X., Zamora, J. C., and Zhang, Y. N.

Subjects
Nuclear Experiment
Abstract

The spin-orbit splitting between neutron 1$p$ orbitals at $^{33}$Si has been deduced using the single-neutron-adding ($d$,$p$) reaction in inverse kinematics with a beam of $^{32}$Si, a long-lived radioisotope. Reaction products were analyzed by the newly implemented SOLARIS spectrometer at the reaccelerated-beam facility at the National Superconducting Cyclotron Laboratory. The measurements show reasonable agreement with shell-model calculations that incorporate modern cross-shell interactions, but they contradict the prediction of proton density depletion based on relativistic mean-field theory. The evolution of the neutron 1$p$-shell orbitals is systematically studied using the present and existing data in the isotonic chains of $N=17$, 19, and 21. In each case, a smooth decrease in the separation of the $1p_{3/2}$-$1p_{1/2}$ orbitals is seen as the respective $p$-orbitals approach zero binding, suggesting that the finite nuclear potential strongly influences the evolution of nuclear structure in this region., Comment: 10 pages, 5 figures

Published
2024

25. A first passage model of intravitreal drug delivery and residence time, in relation to ocular geometry, individual variability, and injection location

Author

Lamirande, Patricia, Gaffney, Eamonn A., Gertz, Michael, Maini, Philip K., Crawshaw, Jessica R., and Caruso, Antonello

Subjects
Quantitative Biology - Quantitative Methods, Mathematics - Analysis of PDEs
Abstract

Purpose: Standard of care for various retinal diseases involves recurrent intravitreal injections. This motivates mathematical modelling efforts to identify influential factors for drug residence time, aiming to minimise administration frequency. We sought to describe the vitreal diffusion of therapeutics in nonclinical species used during drug development assessments. In human eyes, we investigated the impact of variability in vitreous cavity size and eccentricity, and in injection location, on drug elimination. Methods: Using a first passage time approach, we modelled the transport-controlled distribution of two standard therapeutic protein formats (Fab and IgG) and elimination through anterior and posterior pathways. Detailed anatomical 3D geometries of mouse, rat, rabbit, cynomolgus monkey, and human eyes were constructed using ocular images and biometry datasets. A scaling relationship was derived for comparison with experimental ocular half-lives. Results: Model simulations revealed a dependence of residence time on ocular size and injection location. Delivery to the posterior vitreous resulted in increased vitreal half-life and retinal permeation. Interindividual variability in human eyes had a significant influence on residence time (half-life range of 5-7 days), showing a strong correlation to axial length and vitreal volume. Anterior exit was the predominant route of drug elimination. Contribution of the posterior pathway displayed a small (3%) difference between protein formats, but varied between species (10-30%). Conclusions: The modelling results suggest that experimental variability in ocular half-life is partially attributed to anatomical differences and injection site location. Simulations further suggest a potential role of the posterior pathway permeability in determining species differences in ocular pharmacokinetics.

Published
2024
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26. On the speed of propagation in Turing patterns for reaction-diffusion systems

Author

Klika, Václav, Gaffney, Eamonn A., and Maini, Philip K.

Subjects
Nonlinear Sciences - Pattern Formation and Solitons
Abstract

This study investigates transient wave dynamics in Turing pattern formation, focusing on waves emerging from localised disturbances. While the traditional focus of diffusion-driven instability has primarily centred on stationary solutions, considerable attention has also been directed towards understanding spatio-temporal behaviours, particularly the propagation of patterning from localised disturbances. We analyse these waves of patterning using both the well-established marginal stability criterion and weakly nonlinear analysis with envelope equations. Both methods provide estimates for the wave speed but the latter method, in addition, approximates the wave profile and amplitude. We then compare these two approaches analytically near a bifurcation point and reveal that the marginal stability criterion yields exactly the same estimate for the wave speed as the weakly nonlinear analysis. Furthermore, we evaluate these estimates against numerical results for Schnakenberg and CDIMA (chlorine dioxide-iodine-malonic acid) kinetics. In particular, our study emphasises the importance of the characteristic speed of pattern propagation, determined by diffusion dynamics and a complex relation with the reaction kinetics in Turing systems. This speed serves as a vital parameter for comparison with experimental observations, akin to observed pattern length scales. Furthermore, more generally, our findings provide systematic methodologies for analysing transient wave properties in Turing systems, generating insight into the dynamic evolution of pattern formation.

Published
2024

27. Gemini 1.5: Unlocking multimodal understanding across millions of tokens of context

Author

Gemini Team, Georgiev, Petko, Lei, Ving Ian, Burnell, Ryan, Bai, Libin, Gulati, Anmol, Tanzer, Garrett, Vincent, Damien, Pan, Zhufeng, Wang, Shibo, Mariooryad, Soroosh, Ding, Yifan, Geng, Xinyang, Alcober, Fred, Frostig, Roy, Omernick, Mark, Walker, Lexi, Paduraru, Cosmin, Sorokin, Christina, Tacchetti, Andrea, Gaffney, Colin, Daruki, Samira, Sercinoglu, Olcan, Gleicher, Zach, Love, Juliette, Voigtlaender, Paul, Jain, Rohan, Surita, Gabriela, Mohamed, Kareem, Blevins, Rory, Ahn, Junwhan, Zhu, Tao, Kawintiranon, Kornraphop, Firat, Orhan, Gu, Yiming, Zhang, Yujing, Rahtz, Matthew, Faruqui, Manaal, Clay, Natalie, Gilmer, Justin, Co-Reyes, JD, Penchev, Ivo, Zhu, Rui, Morioka, Nobuyuki, Hui, Kevin, Haridasan, Krishna, Campos, Victor, Mahdieh, Mahdis, Guo, Mandy, Hassan, Samer, Kilgour, Kevin, Vezer, Arpi, Cheng, Heng-Tze, de Liedekerke, Raoul, Goyal, Siddharth, Barham, Paul, Strouse, DJ, Noury, Seb, Adler, Jonas, Sundararajan, Mukund, Vikram, Sharad, Lepikhin, Dmitry, Paganini, Michela, Garcia, Xavier, Yang, Fan, Valter, Dasha, Trebacz, Maja, Vodrahalli, Kiran, Asawaroengchai, Chulayuth, Ring, Roman, Kalb, Norbert, Soares, Livio Baldini, Brahma, Siddhartha, Steiner, David, Yu, Tianhe, Mentzer, Fabian, He, Antoine, Gonzalez, Lucas, Xu, Bibo, Kaufman, Raphael Lopez, Shafey, Laurent El, Oh, Junhyuk, Hennigan, Tom, Driessche, George van den, Odoom, Seth, Lucic, Mario, Roelofs, Becca, Lall, Sid, Marathe, Amit, Chan, Betty, Ontanon, Santiago, He, Luheng, Teplyashin, Denis, Lai, Jonathan, Crone, Phil, Damoc, Bogdan, Ho, Lewis, Riedel, Sebastian, Lenc, Karel, Yeh, Chih-Kuan, Chowdhery, Aakanksha, Xu, Yang, Kazemi, Mehran, Amid, Ehsan, Petrushkina, Anastasia, Swersky, Kevin, Khodaei, Ali, Chen, Gowoon, Larkin, Chris, Pinto, Mario, Yan, Geng, Badia, Adria Puigdomenech, Patil, Piyush, Hansen, Steven, Orr, Dave, Arnold, Sebastien M. R., Grimstad, Jordan, Dai, Andrew, Douglas, Sholto, Sinha, Rishika, Yadav, Vikas, Chen, Xi, Gribovskaya, Elena, Austin, Jacob, Zhao, Jeffrey, Patel, Kaushal, Komarek, Paul, Austin, Sophia, Borgeaud, Sebastian, Friso, Linda, Goyal, Abhimanyu, Caine, Ben, Cao, Kris, Chung, Da-Woon, Lamm, Matthew, Barth-Maron, Gabe, Kagohara, Thais, Olszewska, Kate, Chen, Mia, Shivakumar, Kaushik, Agarwal, Rishabh, Godhia, Harshal, Rajwar, Ravi, Snaider, Javier, Dotiwalla, Xerxes, Liu, Yuan, Barua, Aditya, Ungureanu, Victor, Zhang, Yuan, Batsaikhan, Bat-Orgil, Wirth, Mateo, Qin, James, Danihelka, Ivo, Doshi, Tulsee, Chadwick, Martin, Chen, Jilin, Jain, Sanil, Le, Quoc, Kar, Arjun, Gurumurthy, Madhu, Li, Cheng, Sang, Ruoxin, Liu, Fangyu, Lamprou, Lampros, Munoz, Rich, Lintz, Nathan, Mehta, Harsh, Howard, Heidi, Reynolds, Malcolm, Aroyo, Lora, Wang, Quan, Blanco, Lorenzo, Cassirer, Albin, Griffith, Jordan, Das, Dipanjan, Lee, Stephan, Sygnowski, Jakub, Fisher, Zach, Besley, James, Powell, Richard, Ahmed, Zafarali, Paulus, Dominik, Reitter, David, Borsos, Zalan, Joshi, Rishabh, Pope, Aedan, Hand, Steven, Selo, Vittorio, Jain, Vihan, Sethi, Nikhil, Goel, Megha, Makino, Takaki, May, Rhys, Yang, Zhen, Schalkwyk, Johan, Butterfield, Christina, Hauth, Anja, Goldin, Alex, Hawkins, Will, Senter, Evan, Brin, Sergey, Woodman, Oliver, Ritter, Marvin, Noland, Eric, Giang, Minh, Bolina, Vijay, Lee, Lisa, Blyth, Tim, Mackinnon, Ian, Reid, Machel, Sarvana, Obaid, Silver, David, Chen, Alexander, Wang, Lily, Maggiore, Loren, Chang, Oscar, Attaluri, Nithya, Thornton, Gregory, Chiu, Chung-Cheng, Bunyan, Oskar, Levine, Nir, Chung, Timothy, Eltyshev, Evgenii, Si, Xiance, Lillicrap, Timothy, Brady, Demetra, Aggarwal, Vaibhav, Wu, Boxi, Xu, Yuanzhong, McIlroy, Ross, Badola, Kartikeya, Sandhu, Paramjit, Moreira, Erica, Stokowiec, Wojciech, Hemsley, Ross, Li, Dong, Tudor, Alex, Shyam, Pranav, Rahimtoroghi, Elahe, Haykal, Salem, Sprechmann, Pablo, Zhou, Xiang, Mincu, Diana, Li, Yujia, Addanki, Ravi, Krishna, Kalpesh, Wu, Xiao, Frechette, Alexandre, Eyal, Matan, Dafoe, Allan, Lacey, Dave, Whang, Jay, Avrahami, Thi, Zhang, Ye, Taropa, Emanuel, Lin, Hanzhao, Toyama, Daniel, Rutherford, Eliza, Sano, Motoki, Choe, HyunJeong, Tomala, Alex, Safranek-Shrader, Chalence, Kassner, Nora, Pajarskas, Mantas, Harvey, Matt, Sechrist, Sean, Fortunato, Meire, Lyu, Christina, Elsayed, Gamaleldin, Kuang, Chenkai, Lottes, James, Chu, Eric, Jia, Chao, Chen, Chih-Wei, Humphreys, Peter, Baumli, Kate, Tao, Connie, Samuel, Rajkumar, Santos, Cicero Nogueira dos, Andreassen, Anders, Rakićević, Nemanja, Grewe, Dominik, Kumar, Aviral, Winkler, Stephanie, Caton, Jonathan, Brock, Andrew, Dalmia, Sid, Sheahan, Hannah, Barr, Iain, Miao, Yingjie, Natsev, Paul, Devlin, Jacob, Behbahani, Feryal, Prost, Flavien, Sun, Yanhua, Myaskovsky, Artiom, Pillai, Thanumalayan Sankaranarayana, Hurt, Dan, Lazaridou, Angeliki, Xiong, Xi, Zheng, Ce, Pardo, Fabio, Li, Xiaowei, Horgan, Dan, Stanton, Joe, Ambar, Moran, Xia, Fei, Lince, Alejandro, Wang, Mingqiu, Mustafa, Basil, Webson, Albert, Lee, Hyo, Anil, Rohan, Wicke, Martin, Dozat, Timothy, Sinha, Abhishek, Piqueras, Enrique, Dabir, Elahe, Upadhyay, Shyam, Boral, Anudhyan, Hendricks, Lisa Anne, Fry, Corey, Djolonga, Josip, Su, Yi, Walker, Jake, Labanowski, Jane, Huang, Ronny, Misra, Vedant, Chen, Jeremy, Skerry-Ryan, RJ, Singh, Avi, Rijhwani, Shruti, Yu, Dian, Castro-Ros, Alex, Changpinyo, Beer, Datta, Romina, Bagri, Sumit, Hrafnkelsson, Arnar Mar, Maggioni, Marcello, Zheng, Daniel, Sulsky, Yury, Hou, Shaobo, Paine, Tom Le, Yang, Antoine, Riesa, Jason, Rogozinska, Dominika, Marcus, Dror, Badawy, Dalia El, Zhang, Qiao, Wang, Luyu, Miller, Helen, Greer, Jeremy, Sjos, Lars Lowe, Nova, Azade, Zen, Heiga, Chaabouni, Rahma, Rosca, Mihaela, Jiang, Jiepu, Chen, Charlie, Liu, Ruibo, Sainath, Tara, Krikun, Maxim, Polozov, Alex, Lespiau, Jean-Baptiste, Newlan, Josh, Cankara, Zeyncep, Kwak, Soo, Xu, Yunhan, Chen, Phil, Coenen, Andy, Meyer, Clemens, Tsihlas, Katerina, Ma, Ada, Gottweis, Juraj, Xing, Jinwei, Gu, Chenjie, Miao, Jin, Frank, Christian, Cankara, Zeynep, Ganapathy, Sanjay, Dasgupta, Ishita, Hughes-Fitt, Steph, Chen, Heng, Reid, David, Rong, Keran, Fan, Hongmin, van Amersfoort, Joost, Zhuang, Vincent, Cohen, Aaron, Gu, Shixiang Shane, Mohananey, Anhad, Ilic, Anastasija, Tobin, Taylor, Wieting, John, Bortsova, Anna, Thacker, Phoebe, Wang, Emma, Caveness, Emily, Chiu, Justin, Sezener, Eren, Kaskasoli, Alex, Baker, Steven, Millican, Katie, Elhawaty, Mohamed, Aisopos, Kostas, Lebsack, Carl, Byrd, Nathan, Dai, Hanjun, Jia, Wenhao, Wiethoff, Matthew, Davoodi, Elnaz, Weston, Albert, Yagati, Lakshman, Ahuja, Arun, Gao, Isabel, Pundak, Golan, Zhang, Susan, Azzam, Michael, Sim, Khe Chai, Caelles, Sergi, Keeling, James, Sharma, Abhanshu, Swing, Andy, Li, YaGuang, Liu, Chenxi, Bostock, Carrie Grimes, Bansal, Yamini, Nado, Zachary, Anand, Ankesh, Lipschultz, Josh, Karmarkar, Abhijit, Proleev, Lev, Ittycheriah, Abe, Yeganeh, Soheil Hassas, Polovets, George, Faust, Aleksandra, Sun, Jiao, Rrustemi, Alban, Li, Pen, Shivanna, Rakesh, Liu, Jeremiah, Welty, Chris, Lebron, Federico, Baddepudi, Anirudh, Krause, Sebastian, Parisotto, Emilio, Soricut, Radu, Xu, Zheng, Bloxwich, Dawn, Johnson, Melvin, Neyshabur, Behnam, Mao-Jones, Justin, Wang, Renshen, Ramasesh, Vinay, Abbas, Zaheer, Guez, Arthur, Segal, Constant, Nguyen, Duc Dung, Svensson, James, Hou, Le, York, Sarah, Milan, Kieran, Bridgers, Sophie, Gworek, Wiktor, Tagliasacchi, Marco, Lee-Thorp, James, Chang, Michael, Guseynov, Alexey, Hartman, Ale Jakse, Kwong, Michael, Zhao, Ruizhe, Kashem, Sheleem, Cole, Elizabeth, Miech, Antoine, Tanburn, Richard, Phuong, Mary, Pavetic, Filip, Cevey, Sebastien, Comanescu, Ramona, Ives, Richard, Yang, Sherry, Du, Cosmo, Li, Bo, Zhang, Zizhao, Iinuma, Mariko, Hu, Clara Huiyi, Roy, Aurko, Bijwadia, Shaan, Zhu, Zhenkai, Martins, Danilo, Saputro, Rachel, Gergely, Anita, Zheng, Steven, Jia, Dawei, Antonoglou, Ioannis, Sadovsky, Adam, Gu, Shane, Bi, Yingying, Andreev, Alek, Samangooei, Sina, Khan, Mina, Kocisky, Tomas, Filos, Angelos, Kumar, Chintu, Bishop, Colton, Yu, Adams, Hodkinson, Sarah, Mittal, Sid, Shah, Premal, Moufarek, Alexandre, Cheng, Yong, Bloniarz, Adam, Lee, Jaehoon, Pejman, Pedram, Michel, Paul, Spencer, Stephen, Feinberg, Vladimir, Xiong, Xuehan, Savinov, Nikolay, Smith, Charlotte, Shakeri, Siamak, Tran, Dustin, Chesus, Mary, Bohnet, Bernd, Tucker, George, von Glehn, Tamara, Muir, Carrie, Mao, Yiran, Kazawa, Hideto, Slone, Ambrose, Soparkar, Kedar, Shrivastava, Disha, Cobon-Kerr, James, Sharman, Michael, Pavagadhi, Jay, Araya, Carlos, Misiunas, Karolis, Ghelani, Nimesh, Laskin, Michael, Barker, David, Li, Qiujia, Briukhov, Anton, Houlsby, Neil, Glaese, Mia, Lakshminarayanan, Balaji, Schucher, Nathan, Tang, Yunhao, Collins, Eli, Lim, Hyeontaek, Feng, Fangxiaoyu, Recasens, Adria, Lai, Guangda, Magni, Alberto, De Cao, Nicola, Siddhant, Aditya, Ashwood, Zoe, Orbay, Jordi, Dehghani, Mostafa, Brennan, Jenny, He, Yifan, Xu, Kelvin, Gao, Yang, Saroufim, Carl, Molloy, James, Wu, Xinyi, Arnold, Seb, Chang, Solomon, Schrittwieser, Julian, Buchatskaya, Elena, Radpour, Soroush, Polacek, Martin, Giordano, Skye, Bapna, Ankur, Tokumine, Simon, Hellendoorn, Vincent, Sottiaux, Thibault, Cogan, Sarah, Severyn, Aliaksei, Saleh, Mohammad, Thakoor, Shantanu, Shefey, Laurent, Qiao, Siyuan, Gaba, Meenu, Chang, Shuo-yiin, Swanson, Craig, Zhang, Biao, Lee, Benjamin, Rubenstein, Paul Kishan, Song, Gan, Kwiatkowski, Tom, Koop, Anna, Kannan, Ajay, Kao, David, Schuh, Parker, Stjerngren, Axel, Ghiasi, Golnaz, Gibson, Gena, Vilnis, Luke, Yuan, Ye, Ferreira, Felipe Tiengo, Kamath, Aishwarya, Klimenko, Ted, Franko, Ken, Xiao, Kefan, Bhattacharya, Indro, Patel, Miteyan, Wang, Rui, Morris, Alex, Strudel, Robin, Sharma, Vivek, Choy, Peter, Hashemi, Sayed Hadi, Landon, Jessica, Finkelstein, Mara, Jhakra, Priya, Frye, Justin, Barnes, Megan, Mauger, Matthew, Daun, Dennis, Baatarsukh, Khuslen, Tung, Matthew, Farhan, Wael, Michalewski, Henryk, Viola, Fabio, Quitry, Felix de Chaumont, Lan, Charline Le, Hudson, Tom, Wang, Qingze, Fischer, Felix, Zheng, Ivy, White, Elspeth, Dragan, Anca, Alayrac, Jean-baptiste, Ni, Eric, Pritzel, Alexander, Iwanicki, Adam, Isard, Michael, Bulanova, Anna, Zilka, Lukas, Dyer, Ethan, Sachan, Devendra, Srinivasan, Srivatsan, Muckenhirn, Hannah, Cai, Honglong, Mandhane, Amol, Tariq, Mukarram, Rae, Jack W., Wang, Gary, Ayoub, Kareem, FitzGerald, Nicholas, Zhao, Yao, Han, Woohyun, Alberti, Chris, Garrette, Dan, Krishnakumar, Kashyap, Gimenez, Mai, Levskaya, Anselm, Sohn, Daniel, Matak, Josip, Iturrate, Inaki, Chang, Michael B., Xiang, Jackie, Cao, Yuan, Ranka, Nishant, Brown, Geoff, Hutter, Adrian, Mirrokni, Vahab, Chen, Nanxin, Yao, Kaisheng, Egyed, Zoltan, Galilee, Francois, Liechty, Tyler, Kallakuri, Praveen, Palmer, Evan, Ghemawat, Sanjay, Liu, Jasmine, Tao, David, Thornton, Chloe, Green, Tim, Jasarevic, Mimi, Lin, Sharon, Cotruta, Victor, Tan, Yi-Xuan, Fiedel, Noah, Yu, Hongkun, Chi, Ed, Neitz, Alexander, Heitkaemper, Jens, Sinha, Anu, Zhou, Denny, Sun, Yi, Kaed, Charbel, Hulse, Brice, Mishra, Swaroop, Georgaki, Maria, Kudugunta, Sneha, Farabet, Clement, Shafran, Izhak, Vlasic, Daniel, Tsitsulin, Anton, Ananthanarayanan, Rajagopal, Carin, Alen, Su, Guolong, Sun, Pei, V, Shashank, Carvajal, Gabriel, Broder, Josef, Comsa, Iulia, Repina, Alena, Wong, William, Chen, Warren Weilun, Hawkins, Peter, Filonov, Egor, Loher, Lucia, Hirnschall, Christoph, Wang, Weiyi, Ye, Jingchen, Burns, Andrea, Cate, Hardie, Wright, Diana Gage, Piccinini, Federico, Zhang, Lei, Lin, Chu-Cheng, Gog, Ionel, Kulizhskaya, Yana, Sreevatsa, Ashwin, Song, Shuang, Cobo, Luis C., Iyer, Anand, Tekur, Chetan, Garrido, Guillermo, Xiao, Zhuyun, Kemp, Rupert, Zheng, Huaixiu Steven, Li, Hui, Agarwal, Ananth, Ngani, Christel, Goshvadi, Kati, Santamaria-Fernandez, Rebeca, Fica, Wojciech, Chen, Xinyun, Gorgolewski, Chris, Sun, Sean, Garg, Roopal, Ye, Xinyu, Eslami, S. M. Ali, Hua, Nan, Simon, Jon, Joshi, Pratik, Kim, Yelin, Tenney, Ian, Potluri, Sahitya, Thiet, Lam Nguyen, Yuan, Quan, Luisier, Florian, Chronopoulou, Alexandra, Scellato, Salvatore, Srinivasan, Praveen, Chen, Minmin, Koverkathu, Vinod, Dalibard, Valentin, Xu, Yaming, Saeta, Brennan, Anderson, Keith, Sellam, Thibault, Fernando, Nick, Huot, Fantine, Jung, Junehyuk, Varadarajan, Mani, Quinn, Michael, Raul, Amit, Le, Maigo, Habalov, Ruslan, Clark, Jon, Jalan, Komal, Bullard, Kalesha, Singhal, Achintya, Luong, Thang, Wang, Boyu, Rajayogam, Sujeevan, Eisenschlos, Julian, Jia, Johnson, Finchelstein, Daniel, Yakubovich, Alex, Balle, Daniel, Fink, Michael, Agarwal, Sameer, Li, Jing, Dvijotham, Dj, Pal, Shalini, Kang, Kai, Konzelmann, Jaclyn, Beattie, Jennifer, Dousse, Olivier, Wu, Diane, Crocker, Remi, Elkind, Chen, Jonnalagadda, Siddhartha Reddy, Lee, Jong, Holtmann-Rice, Dan, Kallarackal, Krystal, Liu, Rosanne, Vnukov, Denis, Vats, Neera, Invernizzi, Luca, Jafari, Mohsen, Zhou, Huanjie, Taylor, Lilly, Prendki, Jennifer, Wu, Marcus, Eccles, Tom, Liu, Tianqi, Kopparapu, Kavya, Beaufays, Francoise, Angermueller, Christof, Marzoca, Andreea, Sarcar, Shourya, Dib, Hilal, Stanway, Jeff, Perbet, Frank, Trdin, Nejc, Sterneck, Rachel, Khorlin, Andrey, Li, Dinghua, Wu, Xihui, Goenka, Sonam, Madras, David, Goldshtein, Sasha, Gierke, Willi, Zhou, Tong, Liu, Yaxin, Liang, Yannie, White, Anais, Li, Yunjie, Singh, Shreya, Bahargam, Sanaz, Epstein, Mark, Basu, Sujoy, Lao, Li, Ozturel, Adnan, Crous, Carl, Zhai, Alex, Lu, Han, Tung, Zora, Gaur, Neeraj, Walton, Alanna, Dixon, Lucas, Zhang, Ming, Globerson, Amir, Uy, Grant, Bolt, Andrew, Wiles, Olivia, Nasr, Milad, Shumailov, Ilia, Selvi, Marco, Piccinno, Francesco, Aguilar, Ricardo, McCarthy, Sara, Khalman, Misha, Shukla, Mrinal, Galic, Vlado, Carpenter, John, Villela, Kevin, Zhang, Haibin, Richardson, Harry, Martens, James, Bosnjak, Matko, Belle, Shreyas Rammohan, Seibert, Jeff, Alnahlawi, Mahmoud, McWilliams, Brian, Singh, Sankalp, Louis, Annie, Ding, Wen, Popovici, Dan, Simicich, Lenin, Knight, Laura, Mehta, Pulkit, Gupta, Nishesh, Shi, Chongyang, Fatehi, Saaber, Mitrovic, Jovana, Grills, Alex, Pagadora, Joseph, Munkhdalai, Tsendsuren, Petrova, Dessie, Eisenbud, Danielle, Zhang, Zhishuai, Yates, Damion, Mittal, Bhavishya, Tripuraneni, Nilesh, Assael, Yannis, Brovelli, Thomas, Jain, Prateek, Velimirovic, Mihajlo, Akbulut, Canfer, Mu, Jiaqi, Macherey, Wolfgang, Kumar, Ravin, Xu, Jun, Qureshi, Haroon, Comanici, Gheorghe, Wiesner, Jeremy, Gong, Zhitao, Ruddock, Anton, Bauer, Matthias, Felt, Nick, GP, Anirudh, Arnab, Anurag, Zelle, Dustin, Rothfuss, Jonas, Rosgen, Bill, Shenoy, Ashish, Seybold, Bryan, Li, Xinjian, Mudigonda, Jayaram, Erdogan, Goker, Xia, Jiawei, Simsa, Jiri, Michi, Andrea, Yao, Yi, Yew, Christopher, Kan, Steven, Caswell, Isaac, Radebaugh, Carey, Elisseeff, Andre, Valenzuela, Pedro, McKinney, Kay, Paterson, Kim, Cui, Albert, Latorre-Chimoto, Eri, Kim, Solomon, Zeng, William, Durden, Ken, Ponnapalli, Priya, Sosea, Tiberiu, Choquette-Choo, Christopher A., Manyika, James, Robenek, Brona, Vashisht, Harsha, Pereira, Sebastien, Lam, Hoi, Velic, Marko, Owusu-Afriyie, Denese, Lee, Katherine, Bolukbasi, Tolga, Parrish, Alicia, Lu, Shawn, Park, Jane, Venkatraman, Balaji, Talbert, Alice, Rosique, Lambert, Cheng, Yuchung, Sozanschi, Andrei, Paszke, Adam, Kumar, Praveen, Austin, Jessica, Li, Lu, Salama, Khalid, Perz, Bartek, Kim, Wooyeol, Dukkipati, Nandita, Baryshnikov, Anthony, Kaplanis, Christos, Sheng, XiangHai, Chervonyi, Yuri, Unlu, Caglar, Casas, Diego de Las, Askham, Harry, Tunyasuvunakool, Kathryn, Gimeno, Felix, Poder, Siim, Kwak, Chester, Miecnikowski, Matt, Dimitriev, Alek, Parisi, Aaron, Liu, Dangyi, Tsai, Tomy, Shevlane, Toby, Kouridi, Christina, Garmon, Drew, Goedeckemeyer, Adrian, Brown, Adam R., Vijayakumar, Anitha, Elqursh, Ali, Jazayeri, Sadegh, Huang, Jin, Carthy, Sara Mc, Hoover, Jay, Kim, Lucy, Kumar, Sandeep, Chen, Wei, Biles, Courtney, Bingham, Garrett, Rosen, Evan, Wang, Lisa, Tan, Qijun, Engel, David, Pongetti, Francesco, de Cesare, Dario, Hwang, Dongseong, Yu, Lily, Pullman, Jennifer, Narayanan, Srini, Levin, Kyle, Gopal, Siddharth, Li, Megan, Aharoni, Asaf, Trinh, Trieu, Lo, Jessica, Casagrande, Norman, Vij, Roopali, Matthey, Loic, Ramadhana, Bramandia, Matthews, Austin, Carey, CJ, Johnson, Matthew, Goranova, Kremena, Shah, Rohin, Ashraf, Shereen, Dasgupta, Kingshuk, Larsen, Rasmus, Wang, Yicheng, Vuyyuru, Manish Reddy, Jiang, Chong, Ijazi, Joana, Osawa, Kazuki, Smith, Celine, Boppana, Ramya Sree, Bilal, Taylan, Koizumi, Yuma, Xu, Ying, Altun, Yasemin, Shabat, Nir, Bariach, Ben, Korchemniy, Alex, Choo, Kiam, Ronneberger, Olaf, Iwuanyanwu, Chimezie, Zhao, Shubin, Soergel, David, Hsieh, Cho-Jui, Cai, Irene, Iqbal, Shariq, Sundermeyer, Martin, Chen, Zhe, Bursztein, Elie, Malaviya, Chaitanya, Biadsy, Fadi, Shroff, Prakash, Dhillon, Inderjit, Latkar, Tejasi, Dyer, Chris, Forbes, Hannah, Nicosia, Massimo, Nikolaev, Vitaly, Greene, Somer, Georgiev, Marin, Wang, Pidong, Martin, Nina, Sedghi, Hanie, Zhang, John, Banzal, Praseem, Fritz, Doug, Rao, Vikram, Wang, Xuezhi, Zhang, Jiageng, Patraucean, Viorica, Du, Dayou, Mordatch, Igor, Jurin, Ivan, Liu, Lewis, Dubey, Ayush, Mohan, Abhi, Nowakowski, Janek, Ion, Vlad-Doru, Wei, Nan, Tojo, Reiko, Raad, Maria Abi, Hudson, Drew A., Keshava, Vaishakh, Agrawal, Shubham, Ramirez, Kevin, Wu, Zhichun, Nguyen, Hoang, Liu, Ji, Sewak, Madhavi, Petrini, Bryce, Choi, DongHyun, Philips, Ivan, Wang, Ziyue, Bica, Ioana, Garg, Ankush, Wilkiewicz, Jarek, Agrawal, Priyanka, Guo, Danhao, Xue, Emily, Shaik, Naseer, Leach, Andrew, Khan, Sadh MNM, Wiesinger, Julia, Jerome, Sammy, Chakladar, Abhishek, Wang, Alek Wenjiao, Ornduff, Tina, Abu, Folake, Ghaffarkhah, Alireza, Wainwright, Marcus, Cortes, Mario, Liu, Frederick, Maynez, Joshua, Terzis, Andreas, Samangouei, Pouya, Mansour, Riham, Kępa, Tomasz, Aubet, François-Xavier, Algymr, Anton, Banica, Dan, Weisz, Agoston, Orban, Andras, Senges, Alexandre, Andrejczuk, Ewa, Geller, Mark, Santo, Niccolo Dal, Anklin, Valentin, Merey, Majd Al, Baeuml, Martin, Strohman, Trevor, Bai, Junwen, Petrov, Slav, Wu, Yonghui, Hassabis, Demis, Kavukcuoglu, Koray, Dean, Jeff, and Vinyals, Oriol

Subjects
Computer Science - Computation and Language, Computer Science - Artificial Intelligence
Abstract

In this report, we introduce the Gemini 1.5 family of models, representing the next generation of highly compute-efficient multimodal models capable of recalling and reasoning over fine-grained information from millions of tokens of context, including multiple long documents and hours of video and audio. The family includes two new models: (1) an updated Gemini 1.5 Pro, which exceeds the February version on the great majority of capabilities and benchmarks; (2) Gemini 1.5 Flash, a more lightweight variant designed for efficiency with minimal regression in quality. Gemini 1.5 models achieve near-perfect recall on long-context retrieval tasks across modalities, improve the state-of-the-art in long-document QA, long-video QA and long-context ASR, and match or surpass Gemini 1.0 Ultra's state-of-the-art performance across a broad set of benchmarks. Studying the limits of Gemini 1.5's long-context ability, we find continued improvement in next-token prediction and near-perfect retrieval (>99%) up to at least 10M tokens, a generational leap over existing models such as Claude 3.0 (200k) and GPT-4 Turbo (128k). Finally, we highlight real-world use cases, such as Gemini 1.5 collaborating with professionals on completing their tasks achieving 26 to 75% time savings across 10 different job categories, as well as surprising new capabilities of large language models at the frontier; when given a grammar manual for Kalamang, a language with fewer than 200 speakers worldwide, the model learns to translate English to Kalamang at a similar level to a person who learned from the same content.

Published
2024

28. School-Based Tele-Behavioral Health: A Scoping Review of the Literature

Author

Nathaniel A. Sowa, Katie Gaffney, Amanda Sanders, and Caroline Murrell

Abstract

Background: Telehealth utilization exploded during the COVID-19 pandemic, including within school-based health programs. School-based tele-behavioral health can help programs overcome barriers of access to care, but the current state and effectiveness of such programs are unknown. Methods: A scoping literature review was conducted. Studies were included if they described in-school behavioral health services delivered via telehealth for children ages 5 to 18. From the included studies, population, location, setting, intervention, telehealth modality, clinician type, and outcomes assessed were extracted. Findings: Eighteen studies met inclusion criteria. All described psychotherapy or medication management delivered by psychologists (n = 7) and/or psychiatrists (n = 11). Treatment included psychotherapy (N = 8), psychiatric consultation (N = 7), medication management (N = 4), crisis stabilization (N = 1), and caregiver education (N = 1). Eight studies provide qualitative or quantitative outcomes, with 4 examining clinical effectiveness. Conclusions: Despite limited findings in the literature, school-based tele-behavioral health is feasible, effective, and acceptable for delivery of behavioral health care to children and adolescents.

Published
2024
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36. Minimal design of a synthetic cilium

Author

Moreau, Clément, Walker, Benjamin J., Poon, Rebecca N., Soto, Daniel, Goldman, Daniel I., Gaffney, Eamonn A., and Wan, Kirsty Y.

Subjects
Condensed Matter - Soft Condensed Matter, Physics - Biological Physics
Abstract

We study a slender filament beating in a viscous fluid with novel curvature-dependent bending stiffness. Our numerical and experimental investigations reveal that such differential stiffness can sustain planar bending waves far along flexible filaments, in stark contrast to the uniform-stiffness case which requires more sophisticated control. In particular, we establish basal actuation as a viable, parsimonious mechanism for generating high-amplitude planar bending waves. Moreover, the resulting beat patterns closely resemble the power-and-recovery strokes of propulsive biological filaments such as cilia, suggesting extensive applications in robotic and engineered systems., Comment: 7 pages, 4 figures

Published
2024
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37. Towards predicting shear-banding instabilities in lipid monolayers

Author

Carotenuto, A. R., Gaffney, A., Lee, K. Y. C., Pocivavsek, L., Fraldi, M., and Deseri, L.

Subjects
Condensed Matter - Soft Condensed Matter, Physics - Biological Physics
Abstract

Langmuir monolayers are advantageous systems used to investigate how lipid membranes get involved in the physiology of many living structures, such as collapse phenomena in alveolar structures. Much work focuses on characterizing the pressure-bearing capacity of Langmuir films, expressed in the form of isotherm curves. These show that monolayers experience different phases during compression with an according evolution of their mechanical response, incurring into instability events when a critical stress threshold is overcome. Although well-known state equations, which establish an inverse relationship between surface pressure and area change, are able to describe monolayer behavior during liquid expanded phase, the modelling of their nonlinear behavior in the subsequent condensed region is still an open issue. In this regard, efforts are addressed to explain out-of-plane collapse by modeling buckling and wrinkling mainly resorting to linearly elastic plate theory. However, some experiments on Langmuir monolayers also show in-plane instability phenomena leading to the formation of the so-called shear bands and, to date, no theoretical description of the onset of shear banding bifurcation in monolayers has been yet provided. For this reason, by adopting a macroscopic description, we here study material stability of the monolayers and exploit an incremental approach to find the conditions that kindle shear bands. By starting from the widely assumed hypothesis that monolayers behave elastically in the solid-like region, a hyperfoam hyperelastic potential is introduced as a new constitutive strategy to trace back the nonlinear response of monolayer response during densification. In this way, the obtained mechanical properties together with the adopted strain energy are successfully employed to reproduce the onset of shear banding exhibited by some lipid systems under different conditions.

Published
2024
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38. Gemini: A Family of Highly Capable Multimodal Models

Author

Gemini Team, Anil, Rohan, Borgeaud, Sebastian, Alayrac, Jean-Baptiste, Yu, Jiahui, Soricut, Radu, Schalkwyk, Johan, Dai, Andrew M., Hauth, Anja, Millican, Katie, Silver, David, Johnson, Melvin, Antonoglou, Ioannis, Schrittwieser, Julian, Glaese, Amelia, Chen, Jilin, Pitler, Emily, Lillicrap, Timothy, Lazaridou, Angeliki, Firat, Orhan, Molloy, James, Isard, Michael, Barham, Paul R., Hennigan, Tom, Lee, Benjamin, Viola, Fabio, Reynolds, Malcolm, Xu, Yuanzhong, Doherty, Ryan, Collins, Eli, Meyer, Clemens, Rutherford, Eliza, Moreira, Erica, Ayoub, Kareem, Goel, Megha, Krawczyk, Jack, Du, Cosmo, Chi, Ed, Cheng, Heng-Tze, Ni, Eric, Shah, Purvi, Kane, Patrick, Chan, Betty, Faruqui, Manaal, Severyn, Aliaksei, Lin, Hanzhao, Li, YaGuang, Cheng, Yong, Ittycheriah, Abe, Mahdieh, Mahdis, Chen, Mia, Sun, Pei, Tran, Dustin, Bagri, Sumit, Lakshminarayanan, Balaji, Liu, Jeremiah, Orban, Andras, Güra, Fabian, Zhou, Hao, Song, Xinying, Boffy, Aurelien, Ganapathy, Harish, Zheng, Steven, Choe, HyunJeong, Weisz, Ágoston, Zhu, Tao, Lu, Yifeng, Gopal, Siddharth, Kahn, Jarrod, Kula, Maciej, Pitman, Jeff, Shah, Rushin, Taropa, Emanuel, Merey, Majd Al, Baeuml, Martin, Chen, Zhifeng, Shafey, Laurent El, Zhang, Yujing, Sercinoglu, Olcan, Tucker, George, Piqueras, Enrique, Krikun, Maxim, Barr, Iain, Savinov, Nikolay, Danihelka, Ivo, Roelofs, Becca, White, Anaïs, Andreassen, Anders, von Glehn, Tamara, Yagati, Lakshman, Kazemi, Mehran, Gonzalez, Lucas, Khalman, Misha, Sygnowski, Jakub, Frechette, Alexandre, Smith, Charlotte, Culp, Laura, Proleev, Lev, Luan, Yi, Chen, Xi, Lottes, James, Schucher, Nathan, Lebron, Federico, Rrustemi, Alban, Clay, Natalie, Crone, Phil, Kocisky, Tomas, Zhao, Jeffrey, Perz, Bartek, Yu, Dian, Howard, Heidi, Bloniarz, Adam, Rae, Jack W., Lu, Han, Sifre, Laurent, Maggioni, Marcello, Alcober, Fred, Garrette, Dan, Barnes, Megan, Thakoor, Shantanu, Austin, Jacob, Barth-Maron, Gabriel, Wong, William, Joshi, Rishabh, Chaabouni, Rahma, Fatiha, Deeni, Ahuja, Arun, Tomar, Gaurav Singh, Senter, Evan, Chadwick, Martin, Kornakov, Ilya, Attaluri, Nithya, Iturrate, Iñaki, Liu, Ruibo, Li, Yunxuan, Cogan, Sarah, Chen, Jeremy, Jia, Chao, Gu, Chenjie, Zhang, Qiao, Grimstad, Jordan, Hartman, Ale Jakse, Garcia, Xavier, Pillai, Thanumalayan Sankaranarayana, Devlin, Jacob, Laskin, Michael, Casas, Diego de Las, Valter, Dasha, Tao, Connie, Blanco, Lorenzo, Badia, Adrià Puigdomènech, Reitter, David, Chen, Mianna, Brennan, Jenny, Rivera, Clara, Brin, Sergey, Iqbal, Shariq, Surita, Gabriela, Labanowski, Jane, Rao, Abhi, Winkler, Stephanie, Parisotto, Emilio, Gu, Yiming, Olszewska, Kate, Addanki, Ravi, Miech, Antoine, Louis, Annie, Teplyashin, Denis, Brown, Geoff, Catt, Elliot, Balaguer, Jan, Xiang, Jackie, Wang, Pidong, Ashwood, Zoe, Briukhov, Anton, Webson, Albert, Ganapathy, Sanjay, Sanghavi, Smit, Kannan, Ajay, Chang, Ming-Wei, Stjerngren, Axel, Djolonga, Josip, Sun, Yuting, Bapna, Ankur, Aitchison, Matthew, Pejman, Pedram, Michalewski, Henryk, Yu, Tianhe, Wang, Cindy, Love, Juliette, Ahn, Junwhan, Bloxwich, Dawn, Han, Kehang, Humphreys, Peter, Sellam, Thibault, Bradbury, James, Godbole, Varun, Samangooei, Sina, Damoc, Bogdan, Kaskasoli, Alex, Arnold, Sébastien M. R., Vasudevan, Vijay, Agrawal, Shubham, Riesa, Jason, Lepikhin, Dmitry, Tanburn, Richard, Srinivasan, Srivatsan, Lim, Hyeontaek, Hodkinson, Sarah, Shyam, Pranav, Ferret, Johan, Hand, Steven, Garg, Ankush, Paine, Tom Le, Li, Jian, Li, Yujia, Giang, Minh, Neitz, Alexander, Abbas, Zaheer, York, Sarah, Reid, Machel, Cole, Elizabeth, Chowdhery, Aakanksha, Das, Dipanjan, Rogozińska, Dominika, Nikolaev, Vitaliy, Sprechmann, Pablo, Nado, Zachary, Zilka, Lukas, Prost, Flavien, He, Luheng, Monteiro, Marianne, Mishra, Gaurav, Welty, Chris, Newlan, Josh, Jia, Dawei, Allamanis, Miltiadis, Hu, Clara Huiyi, de Liedekerke, Raoul, Gilmer, Justin, Saroufim, Carl, Rijhwani, Shruti, Hou, Shaobo, Shrivastava, Disha, Baddepudi, Anirudh, Goldin, Alex, Ozturel, Adnan, Cassirer, Albin, Xu, Yunhan, Sohn, Daniel, Sachan, Devendra, Amplayo, Reinald Kim, Swanson, Craig, Petrova, Dessie, Narayan, Shashi, Guez, Arthur, Brahma, Siddhartha, Landon, Jessica, Patel, Miteyan, Zhao, Ruizhe, Villela, Kevin, Wang, Luyu, Jia, Wenhao, Rahtz, Matthew, Giménez, Mai, Yeung, Legg, Keeling, James, Georgiev, Petko, Mincu, Diana, Wu, Boxi, Haykal, Salem, Saputro, Rachel, Vodrahalli, Kiran, Qin, James, Cankara, Zeynep, Sharma, Abhanshu, Fernando, Nick, Hawkins, Will, Neyshabur, Behnam, Kim, Solomon, Hutter, Adrian, Agrawal, Priyanka, Castro-Ros, Alex, Driessche, George van den, Wang, Tao, Yang, Fan, Chang, Shuo-yiin, Komarek, Paul, McIlroy, Ross, Lučić, Mario, Zhang, Guodong, Farhan, Wael, Sharman, Michael, Natsev, Paul, Michel, Paul, Bansal, Yamini, Qiao, Siyuan, Cao, Kris, Shakeri, Siamak, Butterfield, Christina, Chung, Justin, Rubenstein, Paul Kishan, Agrawal, Shivani, Mensch, Arthur, Soparkar, Kedar, Lenc, Karel, Chung, Timothy, Pope, Aedan, Maggiore, Loren, Kay, Jackie, Jhakra, Priya, Wang, Shibo, Maynez, Joshua, Phuong, Mary, Tobin, Taylor, Tacchetti, Andrea, Trebacz, Maja, Robinson, Kevin, Katariya, Yash, Riedel, Sebastian, Bailey, Paige, Xiao, Kefan, Ghelani, Nimesh, Aroyo, Lora, Slone, Ambrose, Houlsby, Neil, Xiong, Xuehan, Yang, Zhen, Gribovskaya, Elena, Adler, Jonas, Wirth, Mateo, Lee, Lisa, Li, Music, Kagohara, Thais, Pavagadhi, Jay, Bridgers, Sophie, Bortsova, Anna, Ghemawat, Sanjay, Ahmed, Zafarali, Liu, Tianqi, Powell, Richard, Bolina, Vijay, Iinuma, Mariko, Zablotskaia, Polina, Besley, James, Chung, Da-Woon, Dozat, Timothy, Comanescu, Ramona, Si, Xiance, Greer, Jeremy, Su, Guolong, Polacek, Martin, Kaufman, Raphaël Lopez, Tokumine, Simon, Hu, Hexiang, Buchatskaya, Elena, Miao, Yingjie, Elhawaty, Mohamed, Siddhant, Aditya, Tomasev, Nenad, Xing, Jinwei, Greer, Christina, Miller, Helen, Ashraf, Shereen, Roy, Aurko, Zhang, Zizhao, Ma, Ada, Filos, Angelos, Besta, Milos, Blevins, Rory, Klimenko, Ted, Yeh, Chih-Kuan, Changpinyo, Soravit, Mu, Jiaqi, Chang, Oscar, Pajarskas, Mantas, Muir, Carrie, Cohen, Vered, Lan, Charline Le, Haridasan, Krishna, Marathe, Amit, Hansen, Steven, Douglas, Sholto, Samuel, Rajkumar, Wang, Mingqiu, Austin, Sophia, Lan, Chang, Jiang, Jiepu, Chiu, Justin, Lorenzo, Jaime Alonso, Sjösund, Lars Lowe, Cevey, Sébastien, Gleicher, Zach, Avrahami, Thi, Boral, Anudhyan, Srinivasan, Hansa, Selo, Vittorio, May, Rhys, Aisopos, Konstantinos, Hussenot, Léonard, Soares, Livio Baldini, Baumli, Kate, Chang, Michael B., Recasens, Adrià, Caine, Ben, Pritzel, Alexander, Pavetic, Filip, Pardo, Fabio, Gergely, Anita, Frye, Justin, Ramasesh, Vinay, Horgan, Dan, Badola, Kartikeya, Kassner, Nora, Roy, Subhrajit, Dyer, Ethan, Campos, Víctor Campos, Tomala, Alex, Tang, Yunhao, Badawy, Dalia El, White, Elspeth, Mustafa, Basil, Lang, Oran, Jindal, Abhishek, Vikram, Sharad, Gong, Zhitao, Caelles, Sergi, Hemsley, Ross, Thornton, Gregory, Feng, Fangxiaoyu, Stokowiec, Wojciech, Zheng, Ce, Thacker, Phoebe, Ünlü, Çağlar, Zhang, Zhishuai, Saleh, Mohammad, Svensson, James, Bileschi, Max, Patil, Piyush, Anand, Ankesh, Ring, Roman, Tsihlas, Katerina, Vezer, Arpi, Selvi, Marco, Shevlane, Toby, Rodriguez, Mikel, Kwiatkowski, Tom, Daruki, Samira, Rong, Keran, Dafoe, Allan, FitzGerald, Nicholas, Gu-Lemberg, Keren, Khan, Mina, Hendricks, Lisa Anne, Pellat, Marie, Feinberg, Vladimir, Cobon-Kerr, James, Sainath, Tara, Rauh, Maribeth, Hashemi, Sayed Hadi, Ives, Richard, Hasson, Yana, Noland, Eric, Cao, Yuan, Byrd, Nathan, Hou, Le, Wang, Qingze, Sottiaux, Thibault, Paganini, Michela, Lespiau, Jean-Baptiste, Moufarek, Alexandre, Hassan, Samer, Shivakumar, Kaushik, van Amersfoort, Joost, Mandhane, Amol, Joshi, Pratik, Goyal, Anirudh, Tung, Matthew, Brock, Andrew, Sheahan, Hannah, Misra, Vedant, Li, Cheng, Rakićević, Nemanja, Dehghani, Mostafa, Liu, Fangyu, Mittal, Sid, Oh, Junhyuk, Noury, Seb, Sezener, Eren, Huot, Fantine, Lamm, Matthew, De Cao, Nicola, Chen, Charlie, Mudgal, Sidharth, Stella, Romina, Brooks, Kevin, Vasudevan, Gautam, Liu, Chenxi, Chain, Mainak, Melinkeri, Nivedita, Cohen, Aaron, Wang, Venus, Seymore, Kristie, Zubkov, Sergey, Goel, Rahul, Yue, Summer, Krishnakumaran, Sai, Albert, Brian, Hurley, Nate, Sano, Motoki, Mohananey, Anhad, Joughin, Jonah, Filonov, Egor, Kępa, Tomasz, Eldawy, Yomna, Lim, Jiawern, Rishi, Rahul, Badiezadegan, Shirin, Bos, Taylor, Chang, Jerry, Jain, Sanil, Padmanabhan, Sri Gayatri Sundara, Puttagunta, Subha, Krishna, Kalpesh, Baker, Leslie, Kalb, Norbert, Bedapudi, Vamsi, Kurzrok, Adam, Lei, Shuntong, Yu, Anthony, Litvin, Oren, Zhou, Xiang, Wu, Zhichun, Sobell, Sam, Siciliano, Andrea, Papir, Alan, Neale, Robby, Bragagnolo, Jonas, Toor, Tej, Chen, Tina, Anklin, Valentin, Wang, Feiran, Feng, Richie, Gholami, Milad, Ling, Kevin, Liu, Lijuan, Walter, Jules, Moghaddam, Hamid, Kishore, Arun, Adamek, Jakub, Mercado, Tyler, Mallinson, Jonathan, Wandekar, Siddhinita, Cagle, Stephen, Ofek, Eran, Garrido, Guillermo, Lombriser, Clemens, Mukha, Maksim, Sun, Botu, Mohammad, Hafeezul Rahman, Matak, Josip, Qian, Yadi, Peswani, Vikas, Janus, Pawel, Yuan, Quan, Schelin, Leif, David, Oana, Garg, Ankur, He, Yifan, Duzhyi, Oleksii, Älgmyr, Anton, Lottaz, Timothée, Li, Qi, Yadav, Vikas, Xu, Luyao, Chinien, Alex, Shivanna, Rakesh, Chuklin, Aleksandr, Li, Josie, Spadine, Carrie, Wolfe, Travis, Mohamed, Kareem, Das, Subhabrata, Dai, Zihang, He, Kyle, von Dincklage, Daniel, Upadhyay, Shyam, Maurya, Akanksha, Chi, Luyan, Krause, Sebastian, Salama, Khalid, Rabinovitch, Pam G, M, Pavan Kumar Reddy, Selvan, Aarush, Dektiarev, Mikhail, Ghiasi, Golnaz, Guven, Erdem, Gupta, Himanshu, Liu, Boyi, Sharma, Deepak, Shtacher, Idan Heimlich, Paul, Shachi, Akerlund, Oscar, Aubet, François-Xavier, Huang, Terry, Zhu, Chen, Zhu, Eric, Teixeira, Elico, Fritze, Matthew, Bertolini, Francesco, Marinescu, Liana-Eleonora, Bölle, Martin, Paulus, Dominik, Gupta, Khyatti, Latkar, Tejasi, Chang, Max, Sanders, Jason, Wilson, Roopa, Wu, Xuewei, Tan, Yi-Xuan, Thiet, Lam Nguyen, Doshi, Tulsee, Lall, Sid, Mishra, Swaroop, Chen, Wanming, Luong, Thang, Benjamin, Seth, Lee, Jasmine, Andrejczuk, Ewa, Rabiej, Dominik, Ranjan, Vipul, Styrc, Krzysztof, Yin, Pengcheng, Simon, Jon, Harriott, Malcolm Rose, Bansal, Mudit, Robsky, Alexei, Bacon, Geoff, Greene, David, Mirylenka, Daniil, Zhou, Chen, Sarvana, Obaid, Goyal, Abhimanyu, Andermatt, Samuel, Siegler, Patrick, Horn, Ben, Israel, Assaf, Pongetti, Francesco, Chen, Chih-Wei "Louis", Selvatici, Marco, Silva, Pedro, Wang, Kathie, Tolins, Jackson, Guu, Kelvin, Yogev, Roey, Cai, Xiaochen, Agostini, Alessandro, Shah, Maulik, Nguyen, Hung, Donnaile, Noah Ó, Pereira, Sébastien, Friso, Linda, Stambler, Adam, Kuang, Chenkai, Romanikhin, Yan, Geller, Mark, Yan, ZJ, Jang, Kane, Lee, Cheng-Chun, Fica, Wojciech, Malmi, Eric, Tan, Qijun, Banica, Dan, Balle, Daniel, Pham, Ryan, Huang, Yanping, Avram, Diana, Shi, Hongzhi, Singh, Jasjot, Hidey, Chris, Ahuja, Niharika, Saxena, Pranab, Dooley, Dan, Potharaju, Srividya Pranavi, O'Neill, Eileen, Gokulchandran, Anand, Foley, Ryan, Zhao, Kai, Dusenberry, Mike, Liu, Yuan, Mehta, Pulkit, Kotikalapudi, Ragha, Safranek-Shrader, Chalence, Goodman, Andrew, Kessinger, Joshua, Globen, Eran, Kolhar, Prateek, Gorgolewski, Chris, Ibrahim, Ali, Song, Yang, Eichenbaum, Ali, Brovelli, Thomas, Potluri, Sahitya, Lahoti, Preethi, Baetu, Cip, Ghorbani, Ali, Chen, Charles, Crawford, Andy, Pal, Shalini, Sridhar, Mukund, Gurita, Petru, Mujika, Asier, Petrovski, Igor, Cedoz, Pierre-Louis, Li, Chenmei, Chen, Shiyuan, Santo, Niccolò Dal, Goyal, Siddharth, Punjabi, Jitesh, Kappaganthu, Karthik, Kwak, Chester, LV, Pallavi, Velury, Sarmishta, Choudhury, Himadri, Hall, Jamie, Shah, Premal, Figueira, Ricardo, Thomas, Matt, Lu, Minjie, Zhou, Ting, Kumar, Chintu, Jurdi, Thomas, Chikkerur, Sharat, Ma, Yenai, Yu, Adams, Kwak, Soo, Ähdel, Victor, Rajayogam, Sujeevan, Choma, Travis, Liu, Fei, Barua, Aditya, Ji, Colin, Park, Ji Ho, Hellendoorn, Vincent, Bailey, Alex, Bilal, Taylan, Zhou, Huanjie, Khatir, Mehrdad, Sutton, Charles, Rzadkowski, Wojciech, Macintosh, Fiona, Shagin, Konstantin, Medina, Paul, Liang, Chen, Zhou, Jinjing, Shah, Pararth, Bi, Yingying, Dankovics, Attila, Banga, Shipra, Lehmann, Sabine, Bredesen, Marissa, Lin, Zifan, Hoffmann, John Eric, Lai, Jonathan, Chung, Raynald, Yang, Kai, Balani, Nihal, Bražinskas, Arthur, Sozanschi, Andrei, Hayes, Matthew, Alcalde, Héctor Fernández, Makarov, Peter, Chen, Will, Stella, Antonio, Snijders, Liselotte, Mandl, Michael, Kärrman, Ante, Nowak, Paweł, Wu, Xinyi, Dyck, Alex, Vaidyanathan, Krishnan, R, Raghavender, Mallet, Jessica, Rudominer, Mitch, Johnston, Eric, Mittal, Sushil, Udathu, Akhil, Christensen, Janara, Verma, Vishal, Irving, Zach, Santucci, Andreas, Elsayed, Gamaleldin, Davoodi, Elnaz, Georgiev, Marin, Tenney, Ian, Hua, Nan, Cideron, Geoffrey, Leurent, Edouard, Alnahlawi, Mahmoud, Georgescu, Ionut, Wei, Nan, Zheng, Ivy, Scandinaro, Dylan, Jiang, Heinrich, Snoek, Jasper, Sundararajan, Mukund, Wang, Xuezhi, Ontiveros, Zack, Karo, Itay, Cole, Jeremy, Rajashekhar, Vinu, Tumeh, Lara, Ben-David, Eyal, Jain, Rishub, Uesato, Jonathan, Datta, Romina, Bunyan, Oskar, Wu, Shimu, Zhang, John, Stanczyk, Piotr, Zhang, Ye, Steiner, David, Naskar, Subhajit, Azzam, Michael, Johnson, Matthew, Paszke, Adam, Chiu, Chung-Cheng, Elias, Jaume Sanchez, Mohiuddin, Afroz, Muhammad, Faizan, Miao, Jin, Lee, Andrew, Vieillard, Nino, Park, Jane, Zhang, Jiageng, Stanway, Jeff, Garmon, Drew, Karmarkar, Abhijit, Dong, Zhe, Lee, Jong, Kumar, Aviral, Zhou, Luowei, Evens, Jonathan, Isaac, William, Irving, Geoffrey, Loper, Edward, Fink, Michael, Arkatkar, Isha, Chen, Nanxin, Shafran, Izhak, Petrychenko, Ivan, Chen, Zhe, Jia, Johnson, Levskaya, Anselm, Zhu, Zhenkai, Grabowski, Peter, Mao, Yu, Magni, Alberto, Yao, Kaisheng, Snaider, Javier, Casagrande, Norman, Palmer, Evan, Suganthan, Paul, Castaño, Alfonso, Giannoumis, Irene, Kim, Wooyeol, Rybiński, Mikołaj, Sreevatsa, Ashwin, Prendki, Jennifer, Soergel, David, Goedeckemeyer, Adrian, Gierke, Willi, Jafari, Mohsen, Gaba, Meenu, Wiesner, Jeremy, Wright, Diana Gage, Wei, Yawen, Vashisht, Harsha, Kulizhskaya, Yana, Hoover, Jay, Le, Maigo, Li, Lu, Iwuanyanwu, Chimezie, Liu, Lu, Ramirez, Kevin, Khorlin, Andrey, Cui, Albert, LIN, Tian, Wu, Marcus, Aguilar, Ricardo, Pallo, Keith, Chakladar, Abhishek, Perng, Ginger, Abellan, Elena Allica, Zhang, Mingyang, Dasgupta, Ishita, Kushman, Nate, Penchev, Ivo, Repina, Alena, Wu, Xihui, van der Weide, Tom, Ponnapalli, Priya, Kaplan, Caroline, Simsa, Jiri, Li, Shuangfeng, Dousse, Olivier, Piper, Jeff, Ie, Nathan, Pasumarthi, Rama, Lintz, Nathan, Vijayakumar, Anitha, Andor, Daniel, Valenzuela, Pedro, Lui, Minnie, Paduraru, Cosmin, Peng, Daiyi, Lee, Katherine, Zhang, Shuyuan, Greene, Somer, Nguyen, Duc Dung, Kurylowicz, Paula, Hardin, Cassidy, Dixon, Lucas, Janzer, Lili, Choo, Kiam, Feng, Ziqiang, Zhang, Biao, Singhal, Achintya, Du, Dayou, McKinnon, Dan, Antropova, Natasha, Bolukbasi, Tolga, Keller, Orgad, Reid, David, Finchelstein, Daniel, Raad, Maria Abi, Crocker, Remi, Hawkins, Peter, Dadashi, Robert, Gaffney, Colin, Franko, Ken, Bulanova, Anna, Leblond, Rémi, Chung, Shirley, Askham, Harry, Cobo, Luis C., Xu, Kelvin, Fischer, Felix, Xu, Jun, Sorokin, Christina, Alberti, Chris, Lin, Chu-Cheng, Evans, Colin, Dimitriev, Alek, Forbes, Hannah, Banarse, Dylan, Tung, Zora, Omernick, Mark, Bishop, Colton, Sterneck, Rachel, Jain, Rohan, Xia, Jiawei, Amid, Ehsan, Piccinno, Francesco, Wang, Xingyu, Banzal, Praseem, Mankowitz, Daniel J., Polozov, Alex, Krakovna, Victoria, Brown, Sasha, Bateni, MohammadHossein, Duan, Dennis, Firoiu, Vlad, Thotakuri, Meghana, Natan, Tom, Geist, Matthieu, Girgin, Ser tan, Li, Hui, Ye, Jiayu, Roval, Ofir, Tojo, Reiko, Kwong, Michael, Lee-Thorp, James, Yew, Christopher, Sinopalnikov, Danila, Ramos, Sabela, Mellor, John, Sharma, Abhishek, Wu, Kathy, Miller, David, Sonnerat, Nicolas, Vnukov, Denis, Greig, Rory, Beattie, Jennifer, Caveness, Emily, Bai, Libin, Eisenschlos, Julian, Korchemniy, Alex, Tsai, Tomy, Jasarevic, Mimi, Kong, Weize, Dao, Phuong, Zheng, Zeyu, Liu, Frederick, Zhu, Rui, Teh, Tian Huey, Sanmiya, Jason, Gladchenko, Evgeny, Trdin, Nejc, Toyama, Daniel, Rosen, Evan, Tavakkol, Sasan, Xue, Linting, Elkind, Chen, Woodman, Oliver, Carpenter, John, Papamakarios, George, Kemp, Rupert, Kafle, Sushant, Grunina, Tanya, Sinha, Rishika, Talbert, Alice, Wu, Diane, Owusu-Afriyie, Denese, Thornton, Chloe, Pont-Tuset, Jordi, Narayana, Pradyumna, Li, Jing, Fatehi, Saaber, Wieting, John, Ajmeri, Omar, Uria, Benigno, Ko, Yeongil, Knight, Laura, Héliou, Amélie, Niu, Ning, Gu, Shane, Pang, Chenxi, Li, Yeqing, Levine, Nir, Stolovich, Ariel, Santamaria-Fernandez, Rebeca, Goenka, Sonam, Yustalim, Wenny, Strudel, Robin, Elqursh, Ali, Deck, Charlie, Lee, Hyo, Li, Zonglin, Levin, Kyle, Hoffmann, Raphael, Holtmann-Rice, Dan, Bachem, Olivier, Arora, Sho, Koh, Christy, Yeganeh, Soheil Hassas, Põder, Siim, Tariq, Mukarram, Sun, Yanhua, Ionita, Lucian, Seyedhosseini, Mojtaba, Tafti, Pouya, Liu, Zhiyu, Gulati, Anmol, Liu, Jasmine, Ye, Xinyu, Chrzaszcz, Bart, Wang, Lily, Sethi, Nikhil, Li, Tianrun, Brown, Ben, Singh, Shreya, Fan, Wei, Parisi, Aaron, Stanton, Joe, Koverkathu, Vinod, Choquette-Choo, Christopher A., Li, Yunjie, Lu, TJ, Shroff, Prakash, Varadarajan, Mani, Bahargam, Sanaz, Willoughby, Rob, Gaddy, David, Desjardins, Guillaume, Cornero, Marco, Robenek, Brona, Mittal, Bhavishya, Albrecht, Ben, Shenoy, Ashish, Moiseev, Fedor, Jacobsson, Henrik, Ghaffarkhah, Alireza, Rivière, Morgane, Walton, Alanna, Crepy, Clément, Parrish, Alicia, Zhou, Zongwei, Farabet, Clement, Radebaugh, Carey, Srinivasan, Praveen, van der Salm, Claudia, Fidjeland, Andreas, Scellato, Salvatore, Latorre-Chimoto, Eri, Klimczak-Plucińska, Hanna, Bridson, David, de Cesare, Dario, Hudson, Tom, Mendolicchio, Piermaria, Walker, Lexi, Morris, Alex, Mauger, Matthew, Guseynov, Alexey, Reid, Alison, Odoom, Seth, Loher, Lucia, Cotruta, Victor, Yenugula, Madhavi, Grewe, Dominik, Petrushkina, Anastasia, Duerig, Tom, Sanchez, Antonio, Yadlowsky, Steve, Shen, Amy, Globerson, Amir, Webb, Lynette, Dua, Sahil, Li, Dong, Bhupatiraju, Surya, Hurt, Dan, Qureshi, Haroon, Agarwal, Ananth, Shani, Tomer, Eyal, Matan, Khare, Anuj, Belle, Shreyas Rammohan, Wang, Lei, Tekur, Chetan, Kale, Mihir Sanjay, Wei, Jinliang, Sang, Ruoxin, Saeta, Brennan, Liechty, Tyler, Sun, Yi, Zhao, Yao, Lee, Stephan, Nayak, Pandu, Fritz, Doug, Vuyyuru, Manish Reddy, Aslanides, John, Vyas, Nidhi, Wicke, Martin, Ma, Xiao, Eltyshev, Evgenii, Martin, Nina, Cate, Hardie, Manyika, James, Amiri, Keyvan, Kim, Yelin, Xiong, Xi, Kang, Kai, Luisier, Florian, Tripuraneni, Nilesh, Madras, David, Guo, Mandy, Waters, Austin, Wang, Oliver, Ainslie, Joshua, Baldridge, Jason, Zhang, Han, Pruthi, Garima, Bauer, Jakob, Yang, Feng, Mansour, Riham, Gelman, Jason, Xu, Yang, Polovets, George, Liu, Ji, Cai, Honglong, Chen, Warren, Sheng, XiangHai, Xue, Emily, Ozair, Sherjil, Angermueller, Christof, Li, Xiaowei, Sinha, Anoop, Wang, Weiren, Wiesinger, Julia, Koukoumidis, Emmanouil, Tian, Yuan, Iyer, Anand, Gurumurthy, Madhu, Goldenson, Mark, Shah, Parashar, Blake, MK, Yu, Hongkun, Urbanowicz, Anthony, Palomaki, Jennimaria, Fernando, Chrisantha, Durden, Ken, Mehta, Harsh, Momchev, Nikola, Rahimtoroghi, Elahe, Georgaki, Maria, Raul, Amit, Ruder, Sebastian, Redshaw, Morgan, Lee, Jinhyuk, Zhou, Denny, Jalan, Komal, Li, Dinghua, Hechtman, Blake, Schuh, Parker, Nasr, Milad, Milan, Kieran, Mikulik, Vladimir, Franco, Juliana, Green, Tim, Nguyen, Nam, Kelley, Joe, Mahendru, Aroma, Hu, Andrea, Howland, Joshua, Vargas, Ben, Hui, Jeffrey, Bansal, Kshitij, Rao, Vikram, Ghiya, Rakesh, Wang, Emma, Ye, Ke, Sarr, Jean Michel, Preston, Melanie Moranski, Elish, Madeleine, Li, Steve, Kaku, Aakash, Gupta, Jigar, Pasupat, Ice, Juan, Da-Cheng, Someswar, Milan, M., Tejvi, Chen, Xinyun, Amini, Aida, Fabrikant, Alex, Chu, Eric, Dong, Xuanyi, Muthal, Amruta, Buthpitiya, Senaka, Jauhari, Sarthak, Khandelwal, Urvashi, Hitron, Ayal, Ren, Jie, Rinaldi, Larissa, Drath, Shahar, Dabush, Avigail, Jiang, Nan-Jiang, Godhia, Harshal, Sachs, Uli, Chen, Anthony, Fan, Yicheng, Taitelbaum, Hagai, Noga, Hila, Dai, Zhuyun, Wang, James, Hamer, Jenny, Ferng, Chun-Sung, Elkind, Chenel, Atias, Aviel, Lee, Paulina, Listík, Vít, Carlen, Mathias, van de Kerkhof, Jan, Pikus, Marcin, Zaher, Krunoslav, Müller, Paul, Zykova, Sasha, Stefanec, Richard, Gatsko, Vitaly, Hirnschall, Christoph, Sethi, Ashwin, Xu, Xingyu Federico, Ahuja, Chetan, Tsai, Beth, Stefanoiu, Anca, Feng, Bo, Dhandhania, Keshav, Katyal, Manish, Gupta, Akshay, Parulekar, Atharva, Pitta, Divya, Zhao, Jing, Bhatia, Vivaan, Bhavnani, Yashodha, Alhadlaq, Omar, Li, Xiaolin, Danenberg, Peter, Tu, Dennis, Pine, Alex, Filippova, Vera, Ghosh, Abhipso, Limonchik, Ben, Urala, Bhargava, Lanka, Chaitanya Krishna, Clive, Derik, Li, Edward, Wu, Hao, Hongtongsak, Kevin, Li, Ianna, Thakkar, Kalind, Omarov, Kuanysh, Majmundar, Kushal, Alverson, Michael, Kucharski, Michael, Patel, Mohak, Jain, Mudit, Zabelin, Maksim, Pelagatti, Paolo, Kohli, Rohan, Kumar, Saurabh, Kim, Joseph, Sankar, Swetha, Shah, Vineet, Ramachandruni, Lakshmi, Zeng, Xiangkai, Bariach, Ben, Weidinger, Laura, Vu, Tu, Andreev, Alek, He, Antoine, Hui, Kevin, Kashem, Sheleem, Subramanya, Amar, Hsiao, Sissie, Hassabis, Demis, Kavukcuoglu, Koray, Sadovsky, Adam, Le, Quoc, Strohman, Trevor, Wu, Yonghui, Petrov, Slav, Dean, Jeffrey, and Vinyals, Oriol

Subjects
Computer Science - Computation and Language, Computer Science - Artificial Intelligence, Computer Science - Computer Vision and Pattern Recognition
Abstract

This report introduces a new family of multimodal models, Gemini, that exhibit remarkable capabilities across image, audio, video, and text understanding. The Gemini family consists of Ultra, Pro, and Nano sizes, suitable for applications ranging from complex reasoning tasks to on-device memory-constrained use-cases. Evaluation on a broad range of benchmarks shows that our most-capable Gemini Ultra model advances the state of the art in 30 of 32 of these benchmarks - notably being the first model to achieve human-expert performance on the well-studied exam benchmark MMLU, and improving the state of the art in every one of the 20 multimodal benchmarks we examined. We believe that the new capabilities of the Gemini family in cross-modal reasoning and language understanding will enable a wide variety of use cases. We discuss our approach toward post-training and deploying Gemini models responsibly to users through services including Gemini, Gemini Advanced, Google AI Studio, and Cloud Vertex AI.

Published
2023

40. A US perspective on closing the carbon cycle to defossilize difficult-to-electrify segments of our economy

Author

Shaw, Wendy J, Kidder, Michelle K, Bare, Simon R, Delferro, Massimiliano, Morris, James R, Toma, Francesca M, Senanayake, Sanjaya D, Autrey, Tom, Biddinger, Elizabeth J, Boettcher, Shannon, Bowden, Mark E, Britt, Phillip F, Brown, Robert C, Bullock, R Morris, Chen, Jingguang G, Daniel, Claus, Dorhout, Peter K, Efroymson, Rebecca A, Gaffney, Kelly J, Gagliardi, Laura, Harper, Aaron S, Heldebrant, David J, Luca, Oana R, Lyubovsky, Maxim, Male, Jonathan L, Miller, Daniel J, Prozorov, Tanya, Rallo, Robert, Rana, Rachita, Rioux, Robert M, Sadow, Aaron D, Schaidle, Joshua A, Schulte, Lisa A, Tarpeh, William A, Vlachos, Dionisios G, Vogt, Bryan D, Weber, Robert S, Yang, Jenny Y, Arenholz, Elke, Helms, Brett A, Huang, Wenyu, Jordahl, James L, Karakaya, Canan, Kian, Kourosh Cyrus, Kothandaraman, Jotheeswari, Lercher, Johannes, Liu, Ping, Malhotra, Deepika, Mueller, Karl T, O’Brien, Casey P, Palomino, Robert M, Qi, Long, Rodriguez, José A, Rousseau, Roger, Russell, Jake C, Sarazen, Michele L, Sholl, David S, Smith, Emily A, Stevens, Michaela Burke, Surendranath, Yogesh, Tassone, Christopher J, Tran, Ba, Tumas, William, and Walton, Krista S

Subjects
Chemical Sciences, Climate Action, Responsible Consumption and Production, Chemical sciences
Abstract

Electrification to reduce or eliminate greenhouse gas emissions is essential to mitigate climate change. However, a substantial portion of our manufacturing and transportation infrastructure will be difficult to electrify and/or will continue to use carbon as a key component, including areas in aviation, heavy-duty and marine transportation, and the chemical industry. In this Roadmap, we explore how multidisciplinary approaches will enable us to close the carbon cycle and create a circular economy by defossilizing these difficult-to-electrify areas and those that will continue to need carbon. We discuss two approaches for this: developing carbon alternatives and improving our ability to reuse carbon, enabled by separations. Furthermore, we posit that co-design and use-driven fundamental science are essential to reach aggressive greenhouse gas reduction targets.

Published
2024

41. The impact of low-mode symmetry on inertial fusion energy output in the burning plasma state.

Author

Ralph, J, Ross, J, Zylstra, A, Kritcher, A, Robey, H, Young, C, Hurricane, O, Pak, A, Callahan, D, Baker, K, Casey, D, Döppner, T, Divol, L, Hohenberger, M, Pape, S, Patel, P, Tommasini, R, Ali, S, Amendt, P, Atherton, L, Bachmann, B, Bailey, D, Benedetti, L, Berzak Hopkins, L, Betti, R, Bhandarkar, S, Biener, J, Bionta, R, Birge, N, Bond, E, Bradley, D, Braun, T, Briggs, T, Bruhn, M, Celliers, P, Chang, B, Chapman, T, Chen, H, Choate, C, Christopherson, A, Clark, D, Crippen, J, Dewald, E, Dittrich, T, Edwards, M, Farmer, W, Field, J, Fittinghoff, D, Frenje, J, Gaffney, J, Gatu Johnson, M, Glenzer, S, Grim, G, Haan, S, Hahn, K, Hall, G, Hammel, B, Harte, J, Hartouni, E, Heebner, J, Hernandez, V, Herrmann, H, Herrmann, M, Hinkel, D, Ho, D, Holder, J, Hsing, W, Huang, H, Humbird, K, Izumi, N, Jarrott, L, Jeet, J, Jones, O, Kerbel, G, Kerr, S, Khan, S, Kilkenny, J, Kim, Y, Geppert-Kleinrath, H, Geppert-Kleinrath, V, Kong, C, Koning, J, Kroll, J, Kruse, M, Kustowski, B, Landen, O, Langer, S, Larson, D, Lemos, N, Lindl, J, Ma, T, MacDonald, M, MacGowan, B, Mackinnon, A, MacLaren, S, MacPhee, A, Marinak, M, Mariscal, D, Marley, E, and Masse, L

Abstract

Indirect Drive Inertial Confinement Fusion Experiments on the National Ignition Facility (NIF) have achieved a burning plasma state with neutron yields exceeding 170 kJ, roughly 3 times the prior record and a necessary stage for igniting plasmas. The results are achieved despite multiple sources of degradations that lead to high variability in performance. Results shown here, for the first time, include an empirical correction factor for mode-2 asymmetry in the burning plasma regime in addition to previously determined corrections for radiative mix and mode-1. Analysis shows that including these three corrections alone accounts for the measured fusion performance variability in the two highest performing experimental campaigns on the NIF to within error. Here we quantify the performance sensitivity to mode-2 symmetry in the burning plasma regime and apply the results, in the form of an empirical correction to a 1D performance model. Furthermore, we find the sensitivity to mode-2 determined through a series of integrated 2D radiation hydrodynamic simulations to be consistent with the experimentally determined sensitivity only when including alpha-heating.

Published
2024

44. Performance of plasma p-tau217 for the detection of amyloid-β positivity in a memory clinic cohort using an electrochemiluminescence immunoassay

Author

Dyer, Adam H., Dolphin, Helena, O’Connor, Antoinette, Morrison, Laura, Sedgwick, Gavin, Young, Conor, Killeen, Emily, Gallagher, Conal, McFeely, Aoife, Connolly, Eimear, Davey, Naomi, Claffey, Paul, Doyle, Paddy, Lyons, Shane, Gaffney, Christine, Ennis, Ruth, McHale, Cathy, Joseph, Jasmine, Knight, Graham, Kelly, Emmet, O’Farrelly, Cliona, Fallon, Aoife, O’Dowd, Sean, Bourke, Nollaig M., and Kennelly, Sean P.

Published
2024
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46. A gH/gL-encoding replicon vaccine elicits neutralizing antibodies that protect humanized mice against EBV challenge

Author

Edwards, Kristina R., Malhi, Harman, Schmidt, Karina, Davis, Amelia R., Homad, Leah J., Warner, Nikole L., Chhan, Crystal B., Scharffenberger, Samuel C., Gaffney, Karen, Hinkley, Troy, Potchen, Nicole B., Wang, Jing Yang, Price, Jason, McElrath, M. Juliana, Olson, James, King, Neil P., Lund, Jennifer M., Moodie, Zoe, Erasmus, Jesse H., and McGuire, Andrew T.

Published
2024
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48. Performance improvements and increased ruminal microbial interactions in Angus heifers via supplementation with native rumen bacteria during high-grain challenge

Author

Fan Yang, Madison T. Henniger, Andrew S. Izzo, Emily A. Melchior, Brooke A. Clemmons, Mary A. Oliver, James R. Gaffney, Cameron Martino, Taylor B. Ault-Seay, Miranda L. Striluk, Jordan J. Embree, Juan F. Cordero-Llarena, Pierre-Yves Mulon, David E. Anderson, Mallory M. Embree, and Phillip R. Myer

Subjects
Ruminal acidosis, Grain challenge, Beef cattle, Native rumen microorganism, Medicine, Science
Abstract

Abstract Feedlot cattle may be subjected to digestive disorders, including ruminal acidosis, due to high concentration of grain in their diet. Therefore, novel feeding strategies are required to maximize animal performance and mitigate economic losses in the operation. This study employed a two-period crossover design to assess the effect of direct ruminal administration of native rumen microorganisms (NRM) inoculation on cattle that underwent a high-grain challenge. The NRM inoculation consisted of six microorganisms (1.70 M CFU /day/animal) isolated from the rumen of healthy feedlot cattle: Succinivibrio dextrinosolvens ASCUSBF53, Prevotella albensis ASCUSBF41, Chordicoccus furentiruminis ASCUSBF65, Bacteroides xylanisolvens ASCUSBF52, Clostridium beijerinckii ASCUSBF26, and Syntrophococcus sp. ASCUSBF60. The trial consisted of 16 Angus heifers receiving NRM (n = 8) or a CON (CON = Carrier Buffer; n = 8) inoculation daily for 14-days as pre-challenge while on a high-grain diet and continued daily for a 21-day treatment period. The combined 35 days of microbial supplementation resulted in an improved average daily gain (ADG) of 29% (P = 0.037) and a tendency toward a 19% decrease in the feed efficiency metric, gain to feed ratio (G: F) (P = 0.055). Additionally, administration of NRM to animals on a high-grain diet, improved ruminal microbiome stability (P

Published
2025
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49. Clade 2.3.4.4b but not historical clade 1 HA replicating RNA vaccine protects against bovine H5N1 challenge in mice

Author

David W. Hawman, Thomas Tipih, Eddie Hodge, E. Taylor Stone, Nikole Warner, Natalie McCarthy, Brian Granger, Kimberly Meade-White, Shanna Leventhal, Kiara Hatzakis, Stephanie Park, Karen Gaffney, Kyle Rosenke, Jesse H. Erasmus, and Heinz Feldmann

Subjects
Science
Abstract

Abstract The ongoing circulation of influenza A H5N1 in the United States has raised concerns of a pandemic caused by highly pathogenic avian influenza. Although the United States has stockpiled and is prepared to produce millions of vaccine doses to address an H5N1 pandemic, currently circulating H5N1 viruses contain multiple mutations within the immunodominant head domain of hemagglutinin (HA) compared to the antigens used in stockpiled vaccines. It is unclear if these stockpiled vaccines will need to be updated to match the contemporary H5N1 strains. Here we show that a replicating RNA vaccine expressing the HA of an H5N1 isolated from a US dairy cow confers complete protection against homologous lethal challenge in mice. A repRNA encoding the HA of a clade 1 H5 from 2004 (A/Vietnam/1203/2004) as utilized by some stockpiled vaccines, confers only partial protection. Our data highlight the utility of nucleic acid vaccines to be rapidly updated to match emergent viruses of concern while demonstrating that contemporary bovine H5N1 viruses can evade immunity elicited by historical HA antigens.

Published
2025
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