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Objectives: Using virtual reality (VR), students of radiography can practice acquisition and positioning of musculoskeletal radiographs and get immediate feedback on their performance within the simulator. The purpose of this study was to assess usability of a newly developed VR simulator and to explore self-perceived clinical readiness (SPCR) of radiography students before and after training acquisition of wrist radiographs in the VR simulator., Material and Methods: A prospective methodology was applied where the students ( n = 10) estimated their own SPCR in regard to acquisition of wrist radiographs pre- and post-VR training. A questionnaire on usability, realism, and educational value of the simulator was answered post-VR training. Usability and SPCR scores were calculated. The student's paired t -test was applied to explore the impact of VR training on SPCR., Results: The students (90%) reported that the simulator was realistic and they thought that it could contribute to learning. The pre- and post-SPCR scores were 75 (95% confidence interval [CI]: 54-96) and 77 (95% CI: 59-95), respectively. There was no significant difference ( P = 0.4574) between the pre- and post-SPCR scores., Conclusion: Results indicated that the concept of training acquisition and positioning of wrist radiographs in a VR simulator is feasible with positive feedback from the students. The SPCR scores improved slightly, although not statistically significant, after completion of the training session., Competing Interests: R.O.J. is a co-founder and co-owner of VitaSim. R.O.J. advised the authors M.G.T. and S.K.K.G. on technical solutions to developing the X-ray training module in virtual reality. R.O.J. had no influence on data collection, data analysis, interpretation, or publishing decisions., (© 2023 Published by Scientific Scholar on behalf of Journal of Clinical Imaging Science.)