Search

Background: Mucogingival surgery for root coverage of gingival recessions (GRs) is usually performed in patients with unremarkable periodontal and systemic health. However, the predictable results of surgical procedures and increasingly high aesthetic expectations of patients necessitate optimal management of GR also in patients with systemic conditions that affect the oral cavity. In patients with pemphigus vulgaris (PV), mucosal fragility and complicated surgical management of inflamed soft tissues are major challenges. Methods and Results: A 36‐year‐old female patient with PV and deep GR on the mandibular incisors is presented. After initial unresponsiveness to steroids and immunosuppressants, complete clinical remission was achieved through repeated rituximab infusions and topical platelet‐rich plasma. After > 1 year of stable clinical remission off therapy the patient successfully underwent surgical procedures for vertically coronally advanced flap with connective tissue graft. Conclusions: To the best of our knowledge, no studies have described the surgical management of GR in PV patients. Although controlled studies are required to confirm present results, complete and stable clinical remission is necessary to avoid complications. Collaboration among dermatologists, oral medicine specialists, and periodontologists is essential to determine whether mucogingival surgery for root surface exposure is indicated for PV patients. Key points: Why are these cases new information?This is the first report of root coverage in a patient with oral PV What are the keys to the successful management of these cases?The achievement of complete and stable clinical remission from oral PVMultidisciplinary collaboration among dermatologists, oral medicine specialists, and periodontologists What are the primary limitations to success in these cases?The refractoriness of gingival lesions induced by PVPoor mucogingival conditions of inflamed gingival tissues exacerbated by PV [ABSTRACT FROM AUTHOR]

Introduction: We recently developed a non‐invasive sampling procedure for oral squamous cell carcinoma (OSCC) detection based on DNA methylation analysis of a panel of 13 genes. Oral cancer, as well as acute and chronic inflammatory diseases, may influence the methylation level of several genes in the oral cavity. In the present study, we evaluated the presence of periodontal disease (PD) and the methylation status using our 13‐gene panel. Methods: Oral brushing specimens were collected from three different patient groups: 23 gingival OSCC patients, 15 patients affected by PD, and 15 healthy volunteers lacking evidence of PD. DNA methylation analysis was performed and each sample was determined to be positive or negative based on a predefined cut‐off value. Results: Positive results were found for 23/23 OSCC patients, 3/15 PD patients, and 0/15 samples from healthy volunteers. The GP1BB and MIR193 genes in the PD group exhibited mean methylation levels similar to OSCC patients. ZAP70 showed different methylation levels among three groups. Conclusion: Preliminary data identified shared epigenetic alterations between PD and OSCC patients in two inflammatory genes (GP1BB and MIR193). This study may help to identify potential links between the two diseases and serve as a starting point for the future research focused on pathogenesis. [ABSTRACT FROM AUTHOR]

The article presents the case of an elderly female patient with a non-healing ulcer on the lateral border of the tongue and was referred to the Dermatologic Unit of the University of Bologna. Topics discussed include description on the ulcer, challenges of the diagnosis of plasma cell mucositis (PCM), and treatment of the patient with local steroids and prednisone.

We analyzed the genetic and epigenetic profiles of an oral squamous cell carcinoma affecting a 41-year-old pregnant female. The patient presented with an oral mass located at the hard and soft palate with bone involvement and lymph node metastases (T4N1M0). She had been treated with multimodal radiotherapy and chemotherapy, and she is currently alive with no evidence of disease 8 years after treatment. DNA methylation and DNA mutation analyses were used to analyze multiple samples from the tumor mass and from the non-neoplastic mucosa to verify tumor heterogeneity. Genetic and epigenetic analyses revealed the presence of one shared TP53 driver mutation with the same DNA methylation profile in each of the 3 areas of the tumor mass; only 2 additional passenger mutations were detected, suggesting a simple clonal homogeneous carcinoma, which usually is associated with low-level aggressive behavior. Additionally, no genetic or epigenetic alteration in the non-neoplastic oral mucosa was detected, demonstrating the absence of field cancerization. The low aggressiveness of the lesion was confirmed by the patient being free of disease at a long-term follow-up examination. These data suggest a different molecular transformation pathway in pregnancy-related oral squamous cell carcinomas, providing new perspectives for further investigation. [ABSTRACT FROM AUTHOR]

Recently, LPP has been defined as an entity in its own right, the hallmarks of which are lichenoid and bullous skin lesions, which develop in the context of autoantibodies targeting collagen type XVII (COL17). Enzyme-linked immunosorbent assay (ELISA) was positive for anti-BP180 autoantibodies (112 U/ml) and negative for anti-BP230, Dsg1, and Dsg3 autoantibodies. Direct immunofluorescence (DIF) of a biopsy drawn from the palatine perilesional skin revealed immunoglobulin G (IgG) and C3 deposition at the basement membrane zone (BMZ) (Fig. [Extracted from the article]

The article describes the case of a 78-year-old patient with longstanding, painful, and widespread oral ulcerative lesions and erosive plaques. The patient was hospitalized due to SARS-COV-2 related severe pneumonia and acute respiratory distress. Also mentioned are the appearance of oral lesions few days after the onset of respiratory symptoms which worsened during hospitalization, the treatment given to pneumonia, and the relevance of oral examination in proved or suspected COVID-19 patients.