1. Case report: Regression of Glioblastoma after flavivirus infection
- Author
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Patricia P. Garcez, André Guasti, Nina Ventura, Luiza Mendonça Higa, Felipe Andreiuolo, Gabriella Pinheiro A. de Freitas, Liane de Jesus Ribeiro, Richard Araújo Maia, Sheila Maria Barbosa de Lima, Adriana de Souza Azevedo, Waleska Dias Schwarcz, Elena Cristina Caride, Leila Chimelli, Luiz Gustavo Dubois, Orlando da Costa Ferreira Júnior, Amilcar Tanuri, Vivaldo Moura-Neto, and Paulo Niemeyer
- Subjects
glioblastoma ,flavivirus ,oncolytic virus ,ZIKV ,DENV ,immunovirotherapy ,Medicine (General) ,R5-920 - Abstract
Glioblastoma is the most frequent and aggressive primary brain cancer. In preclinical studies, Zika virus, a flavivirus that triggers the death of glioblastoma stem-like cells. However, the flavivirus oncolytic activity has not been demonstrated in human patients. Here we report a glioblastoma patient who received the standard of care therapy, including surgical resection, radiotherapy and temozolomide. However, shortly after the tumor mass resection, the patient was clinically diagnosed with a typical arbovirus-like infection, during a Zika virus outbreak in Brazil. Following the infection resolution, the glioblastoma regressed, and no recurrence was observed. This clinical response continues 6 years after the glioblastoma initial diagnosis.
- Published
- 2023
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