1. Autologous micro‐fragmented adipose tissue injection provides significant and prolonged clinical improvement in patients with knee osteoarthritis: a case‐series study
- Author
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Arcangelo Russo, Gabriele Cortina, Vincenzo Condello, Marco Collarile, Roberto Orlandi, Riccardo Gianoli, Emanuele Giuliani, and Vincenzo Madonna
- Subjects
Micro‐fragmented Adipose Tissue (MAT) ,Mesenchymal Stem Cells or Medicinal Signalling ,Cells (MSCs) ,Knee Osteoarthritis (KOA) ,Minimal Clinical Important Difference (MCID) ,Orthopedic surgery ,RD701-811 - Abstract
Abstract Purpose Among the conservative strategies to manage patients with symptomatic knee osteoarthritis (OA), an innovative approach exploiting the regenerative capability of adipose tissue and its resident MSCs (Mesenchymal Stem Cells or Medicinal Signalling Cells) has been proposed with encouraging results. This study aims to demonstrate the benefits of autologous micro‐fragmented adipose tissue (MAT) injection in the conservative treatment of knee osteoarthritis and whether any variables may affect the outcome. This is a case series single‐centre study in which patients underwent intraarticular MAT injection without any associated procedures. Methods Based on inclusion and exclusion criteria, 49 patients (67 Knees) were included and retrospectively analysed with a mean follow‐up of 34.04 ± 13.62 months (minimum 11 – maximum 59). Patients were assessed through the WOMAC and KOOS questionnaires at baseline (pre‐treatment) and 1‐, 3‐, 6‐, 12‐, 24‐ and 36‐month follow‐up. A minimal clinically important difference (MCID) of at least 7.5 points for the WOMAC pain scale and 7.2 for the WOMAC function scale compared to the baseline value was used. Results WOMAC and KOOS scores improved after treatment compared to baseline at all follow‐ups with p
- Published
- 2023
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