1. Comparative study of polymorphism frequencies of the CYP2D6, CYP3A5, CYP2C8 and IL-10 genes in Mexican and Spanish women with breast cancer
- Author
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Laureano Simon-Buela, Gabriela Rubio-Hernández, Ana Laura Calderón-Garcidueñas, Ana Lilia Castruita-Ávila, Gregorio Antonio Alcazar-González, Stéphane le Brun, María Lourdes Garza-Rodríguez, Ricardo M. Cerda-Flores, Sergio Escorza-Treviño, Estibaliz Olano-Martin, Hugo A. Barrera-Saldaña, and Juan Francisco González-Guerrero
- Subjects
Adult ,Oncology ,Antimetabolites, Antineoplastic ,medicine.medical_specialty ,Antineoplastic Agents, Hormonal ,Genotype ,Paclitaxel ,Breast Neoplasms ,Deoxycytidine ,Cytochrome P-450 CYP2C8 ,Capecitabine ,Breast cancer ,Internal medicine ,Genetics ,Cytochrome P-450 CYP3A ,Humans ,Medicine ,CYP3A5 ,Mexico ,Genotyping ,Pharmacology ,Polymorphism, Genetic ,business.industry ,Middle Aged ,medicine.disease ,Antineoplastic Agents, Phytogenic ,Interleukin-10 ,Tamoxifen ,Cytochrome P-450 CYP2D6 ,Spain ,Cancer research ,Molecular Medicine ,Female ,DPYD ,Aryl Hydrocarbon Hydroxylases ,Fluorouracil ,Gene polymorphism ,business ,Pharmacogenetics ,medicine.drug - Abstract
Aim: Pharmacogenetic studies in breast cancer (BC) may predict the efficacy of tamoxifen and the toxicity of paclitaxel and capecitabine. We determined the frequency of polymorphisms in the CYP2D6 gene associated with activation of tamoxifen, and those of the genes CYP2C8, CYP3A5 and DPYD associated with toxicity of paclitaxel and capecitabine. We also included a IL-10 gene polymorphism associated with advanced tumor stage at diagnosis. Patients & methods: Genomic DNAs from 241 BC patients from northeast Mexico were genotyped using DNA microarray technology. Results: For tamoxifen processing, CYP2D6 genotyping predicted that 90.8% of patients were normal metabolizers, 4.2% ultrarapid, 2.1% intermediate and 2.9% poor metabolizers. For paclitaxel and the CYP2C8 gene, 75.3% were normal, 23.4% intermediate and 1.3% poor metabolizers. Regarding the DPYD gene, only one patient was a poor metabolizer. For the IL-10 gene, 47.1% were poor metabolizers. Conclusion: These results contribute valuable information towards personalizing BC chemotherapy in Mexican women. Original submitted 1 February 2013; revision submitted 22 April 2013
- Published
- 2013
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