6 results on '"Gabriela Monico"'
Search Results
2. The Comparative Effects of Various Moisturizers on Epidermal Barrier Function Recovery After Bathing in Atopic Dermatitis
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Nicole Takeda, Suzana S. Bosanac, Lawrence F. Eichenfield, Vivian Y. Shi, W. Burney, Raja K Sivamani, Gabriela Monico, Jennifer Ornelas, Lauren A Hassoun, Negar Foolad, and Melody Maarouf
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Transepidermal water loss ,Epidermal barrier ,Bathing ,biology ,business.industry ,medicine.medical_treatment ,Physiology ,Atopic dermatitis ,biology.organism_classification ,medicine.disease ,Aloe vera ,Humectant ,medicine.drug_formulation_ingredient ,medicine ,Moisturizer ,business ,White petrolatum - Abstract
Background/Aims: An important pillar of AD management involves moisturizer application following bathing to restore epidermal barrier function (EBF). In this study, we aim to bring additional evidence to the “soak-and-smear” regimen, comparing EBF recovery by various moisturizers following bathing in AD and healthy subjects. Methods: Volar forearms of 10 AD patients and 10 healthy controls were immersed in water for 10 minutes to simulate bathing. Immediately after bathing, ceramide-containing emollient (CER), a humectant (10% glycerin, GLY), an occlusant (white petrolatum, PETR), and aloe vera 5% extract (ALOE) were applied to separate test sites on the forearm. One test site did not receive any moisturizer and served as control. EBF parameters (hydration, TEWL, and pH) were recorded at baseline, and 15, 30, and 60-minutes post-bathing.Results: AD and controls shared similar trends. ALOE had the most significant pH decrease while GLY had the highest pH increase. Hydration significantly increased in all moisturizers compared to control. GLY led to the highest increase, peaking at 15-minutes for both AD and healthy subjects. AD subjects had higher hydration following CER than healthy subjects throughout the entire study. All four moisturizers increased TEWL compared to control, though PETR had the lowest initial TEWL increase. Conclusion: All moisturizers has an immediate effect on improving SC hydration. Their initial effects on TEWL increase recovers toward control levels by 60-minutes. Future studies are needed to examine the effect of repeated moisturizer post-bathing over longer study periods.
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- 2018
3. Anxiety levels of patients undergoing common dermatologic procedures versus those seeking general dermatologic care
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Tatyana A. Petukhova, Faranak Kamangar, Stephen Mathis, Yu Liu, Gabriela Monico, Chin-Shang Li, Jayne S Joo, Elle Lee, Anne Zhuang, and Daniel B. Eisen
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medicine.medical_specialty ,Patient anxiety ,Patients ,Visual analogue scale ,Office Visits ,Biopsy ,Dermatologic Surgical Procedures ,MEDLINE ,050109 social psychology ,Dermatology ,Anxiety ,Micrographic surgery ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Humans ,0501 psychology and cognitive sciences ,Shave biopsy ,Dermatologic Procedures ,medicine.diagnostic_test ,business.industry ,05 social sciences ,General Medicine ,Common procedures ,Mohs Surgery ,patient anxiety, dermatology, dermatology surgery ,medicine.symptom ,Mohs micrographic surgery ,business - Abstract
Patients undergoing Mohs micrographic surgery frequently experience anxiety as a result of multiple potential factors. There is currently no data regarding how this anxiety compares to other common procedures performed in dermatology offices, such as shave biopsy and excision, relative to a general dermatology visit. Herein, we conducted a survey of 471 dermatology patients at an academic medical center, using a validated tool (Visual Analogue Scale from 1 "no anxiety at all" to 10 "extremely anxious").
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- 2017
4. Detection of GNAQ mutations and reduction of cell viability in uveal melanoma cells with functionalized gold nanoparticles
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Martina Sanlorenzo, Mitchell Zekhtser, Ana Latorre, Michelle B. Crosby, Gary A. Green, Igor Vujic, Jeffrey Ma, Jingly F. Weier, Anna Celli, Devron H. Char, Susana Ortiz-Urda, Denis Jusufbegovic, Christian Posch, Alfonso Latorre, Álvaro Somoza, Klemens Rappersberger, and Gabriela Monico
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Adult ,Uveal Neoplasms ,Small interfering RNA ,Cell Survival ,Mutant ,Biomedical Engineering ,Metal Nanoparticles ,Biosensing Techniques ,Biology ,medicine.disease_cause ,Article ,Cell Line, Tumor ,medicine ,Humans ,Viability assay ,RNA, Messenger ,RNA, Neoplasm ,Molecular Biology ,Melanoma ,Genetics ,Mutation ,Gene knockdown ,GNA11 ,medicine.disease ,GTP-Binding Protein alpha Subunits ,Neoplasm Proteins ,Gene Knockdown Techniques ,Cancer research ,GTP-Binding Protein alpha Subunits, Gq-G11 ,Gold ,GNAQ - Abstract
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. Early treatment may improve any chances of preventing metastatic disease, but diagnosis of small UM is challenging. Up to 95 % of all UMs carry somatic mutations in the G-coupled proteins GNAQ and GNA11 promoting anchorage-independent growth and proliferation. About 50 % of UMs are fatal. Once metastatic, patients have limited options for successful therapy. We have developed functionalized gold nanoparticles (AuNPs) to visualize transcripts of mutant GNAQ mRNA in living cells. In addition to their suitability as a specific tool for GNAQ mutation detection, we have developed a novel linker that enables conjugation of siRNAs to AuNPs allowing for greater and more rapid intracellular release of siRNAs compared to previously described approaches. Binding of modified AuNPs to matching target mRNA leads to conformational changes, resulting in a detectable fluorescent signal that can be used for mutation detection in living cells. Knockdown of GNAQ with siRNA-AuNPs effectively reduced downstream signals and decreased cell viability in GNAQ mutant uveal melanoma cells. AuNPs may in future be developed to serve as sensors for mutations of vital importance. The new release system for siRNA-AuNP improves previous systems, which conceivably will be useful for future therapeutic gene regulatory approaches.
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- 2015
5. The use of botanical products and vitamins in sunscreens
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Raja K Sivamani, Micheal Leo, Gabriela Monico, Thomas Ma, Ritika S Johal, and Brian Ma
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Retinyl Esters ,Cost-Benefit Analysis ,Sunscreening Agents ,Dermatology ,Aloe vera ,Toxicology ,chemistry.chemical_compound ,Sun protection factor ,Retinyl palmitate ,Glycyrrhiza ,Medicine ,Humans ,Aloe ,Vitamin A ,Skin care ,Traditional medicine ,biology ,business.industry ,Plant Extracts ,General Medicine ,Vitamins ,biology.organism_classification ,chemistry ,Diterpenes ,business ,Sun Protection Factor - Abstract
The use of botanical products and vitamins in skin care creams and sunscreens is prevalent. Herein we conduct an evaluation of sunscreens to quantitatively assess how often sunscreens incorporate botanically derived products and vitamins. The most commonly used botanicals products and vitamins are identified and stratified based on the sunscreen sun protection factor (SPF). The overall prevalence for the use of botanical agents and vitamins was 62% and 79%, respectively. Aloe vera and licorice root extracts were the most common botanical agents used in sunscreens. Retinyl palmitate was the most common vitamin derivative utilized in sunscreens. The prices of sunscreens significantly increased when more than one botanical product was added. Botanical products and vitamins are widely utilized in sunscreens and more research is needed to assess how their inclusion may enhance or alter the function of sunscreens.
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- 2015
6. The risk of melanoma in airline pilots and cabin crew: a meta-analysis
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Mackenzie R. Wehner, Christian Posch, Katia Johnston, Eleni Linos, John Kornak, Simona Osella-Abate, James T. McGrath, Gabriela Monico, James E. Cleaver, Martina Sanlorenzo, Pietro Quaglino, Susana Ortiz-Urda, Igor Vujic, Wolfgang Kainz, and Deborah Gho
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Risk ,Funnel plot ,Skin Neoplasms ,Web of science ,Aircraft ,Ultraviolet Rays ,Population ,Clinical Sciences ,Oncology and Carcinogenesis ,Crew ,airline pilots ,Dermatology ,Article ,Clinical Research ,Occupational Exposure ,Medicine ,Humans ,melanoma risk ,education ,Melanoma ,Rank correlation ,Cancer ,education.field_of_study ,business.industry ,Incidence (epidemiology) ,Incidence ,Prevention ,melanoma risk, airline pilots, cabine crew ,Occupational Diseases ,Standardized mortality ratio ,Meta-analysis ,Linear Models ,business ,Aviation ,cabine crew ,Cosmic Radiation ,Demography - Abstract
ImportanceAirline pilots and cabin crew are occupationally exposed to higher levels of cosmic and UV radiation than the general population, but their risk of developing melanoma is not yet established.ObjectiveTo assess the risk of melanoma in pilots and airline crew.Data sourcesPubMed (1966 to October 30, 2013), Web of Science (1898 to January 27, 2014), and Scopus (1823 to January 27, 2014).Study selectionAll studies were included that reported a standardized incidence ratio (SIR), standardized mortality ratio (SMR), or data on expected and observed cases of melanoma or death caused by melanoma that could be used to calculate an SIR or SMR in any flight-based occupation.Data extraction and synthesisPrimary random-effect meta-analyses were used to summarize SIR and SMR for melanoma in any flight-based occupation. Heterogeneity was assessed using the χ2 test and I2 statistic. To assess the potential bias of small studies, we used funnel plots, the Begg rank correlation test, and the Egger weighted linear regression test.Main outcomes and measuresSummary SIR and SMR of melanoma in pilots and cabin crew.ResultsOf the 3527 citations retrieved, 19 studies were included, with more than 266 431 participants. The overall summary SIR of participants in any flight-based occupation was 2.21 (95% CI, 1.76-2.77; P
- Published
- 2015
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