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6 results on '"Gabriela López-Arango"'

1. EEG repetition and change detection responses in infancy predict adaptive functioning in preschool age: a longitudinal study

Author

Florence Deguire, Gabriela López-Arango, Inga Sophia Knoth, Valérie Côté, Kristian Agbogba, and Sarah Lippé

Subjects
Medicine, Science
Abstract

Abstract Neurodevelopmental disorders (NDDs) are mostly diagnosed around the age of 4–5 years, which is too late considering that the brain is most susceptive to interventions during the first two years of life. Currently, diagnosis of NDDs is based on observed behaviors and symptoms, but identification of objective biomarkers would allow for earlier screening. In this longitudinal study, we investigated the relationship between repetition and change detection responses measured using an EEG oddball task during the first year of life and at two years of age, and cognitive abilities and adaptive functioning during preschool years (4 years old). Identification of early biomarkers is challenging given that there is a lot of variability in developmental courses among young infants. Therefore, the second aim of this study is to assess whether brain growth is a factor of interindividual variability that influences repetition and change detection responses. To obtain variability in brain growth beyond the normative range, infants with macrocephaly were included in our sample. Thus, 43 normocephalic children and 20 macrocephalic children were tested. Cognitive abilities at preschool age were assessed with the WPPSI-IV and adaptive functioning was measured with the ABAS-II. Time–frequency analyses were conducted on the EEG data. Results indicated that repetition and change detection responses in the first year of life predict adaptive functioning at 4 years of age, independently of head circumference. Moreover, our findings suggested that brain growth explains variability in neural responses mostly in the first years of life, so that macrocephalic children did not display repetition suppression responses, while normocephalic children did. This longitudinal study demonstrates that the first year of life is an important period for the early screening of children at risk of developing NDDs.

Published
2023
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2. Impact of brain overgrowth on sensorial learning processing during the first year of life

Author

Gabriela López-Arango, Florence Deguire, Kristian Agbogba, Marc-Antoine Boucher, Inga S. Knoth, Ramy El-Jalbout, Valérie Côté, Amélie Damphousse, Samuel Kadoury, and Sarah Lippé

Subjects
repetition suppression, change detection, macrocephaly, time-frequency analysis, ERPs (event related potentials), Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Macrocephaly is present in about 2–5% of the general population. It can be found as an isolated benign trait or as part of a syndromic condition. Brain overgrowth has been associated with neurodevelopmental disorders such as autism during the first year of life, however, evidence remains inconclusive. Furthermore, most of the studies have involved pathological or high-risk populations, but little is known about the effects of brain overgrowth on neurodevelopment in otherwise neurotypical infants. We investigated the impact of brain overgrowth on basic perceptual learning processes (repetition effects and change detection response) during the first year of life. We recorded high density electroencephalograms (EEG) in 116 full-term healthy infants aged between 3 and 11 months, 35 macrocephalic (14 girls) and 81 normocephalic (39 girls) classified according to the WHO head circumference norms. We used an adapted oddball paradigm, time-frequency analyses, and auditory event-related brain potentials (ERPs) to investigate differences between groups. We show that brain overgrowth has a significant impact on repetition effects and change detection response in the 10–20 Hz frequency band, and in N450 latency, suggesting that these correlates of sensorial learning processes are sensitive to brain overgrowth during the first year of life.

Published
2022
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3. Impact of macrocephaly, as an isolated trait, on EEG signal as measured by spectral power and multiscale entropy during the first year of life

Author

Gabriela López-Arango, Florence Deguire, Kristian Agbogba, Élisabeth Audet-Duchesne, Marc-Antoine Boucher, Inga S. Knoth, Ramy El-Jalbout, Amélie Damphousse, Samuel Kadoury, and Sarah Lippé

Subjects
Developmental Neuroscience, Neurology
Abstract

Macrocephaly has been associated with neurodevelopmental disorders; however, it has been mainly studied in the context of pathological or high-risk populations and little is known about its impact, as an isolated trait, on brain development in general population. Electroencephalographic (EEG) power spectral density (PSD) and signal complexity have shown to be sensitive to neurodevelopment and its alterations. We aimed to investigate the impact of macrocephaly as isolated trait on EEG signal as measured by power spectral density (PSD) and Multiscale Entropy (MSE) during the first year of life. We recorded high density EEG resting state activity of 74 healthy full-term infants, 50 control (26 girls) and 24 macrocephalic (12 girls) aged between 3 and 11 months. We used linear regression models to assess group and age effects on EEG power spectral density (PSD) and signal complexity. Sex and brain volume measures, obtained via a 3D transfontanellar ultrasound, were also included into the models to evaluate their contribution. Our results showed lower PSD of the low alpha (8-10Hz) frequency band and lower complexity in the macrocephalic group compared to the control group. In addition, we found an increase in low alpha (8.5-10Hz) PSD and in the complexity index with age. These findings suggest that macrocephaly as an isolated trait has a significant impact on brain activity during the first year of life.

Published
2023

4. Is the N400 category-specific? A face and language processing study

Author

Gabriela López Arango, Martial Van der Linden, Françoise Jermann, and Roberto Caldara

Subjects
Face (sociological concept), Electroencephalography, Semantics, Brain mapping, Event-related potential, medicine, Humans, Semantic memory, Evoked Potentials, Cerebral Cortex, Analysis of Variance, Brain Mapping, Facial expression, Communication, medicine.diagnostic_test, business.industry, General Neuroscience, N400, Facial Expression, Pattern Recognition, Visual, business, Psychology, Photic Stimulation, Cognitive psychology
Abstract

N400 event-related potential (ERP) components have been observed during semantic incongruity detection in language, face identity and/or expression. However, it is still unclear whether semantic processing is functionally equivalent, since no study has directly investigated within the same participants the occurrence of the N400s for language and faces. We recorded ERPs while subjects performed incongruity detection on words, facial identities and facial e

Published
2004

5. Neuropsychological test performance in illiterate subjects

Author

Feggy Ostrosky-Solís, Monica Rosselli, Victor Uriel-Mendoza, Alfredo Ardila, and Gabriela López-Arango

Subjects
medicine.diagnostic_test, Phonology, General Medicine, Neuropsychological test, Age and sex, Developmental psychology, Comprehension, Psychiatry and Mental health, Clinical Psychology, Neuropsychology and Physiological Psychology, Formal education, medicine, Verbal fluency test, Aging effect, Psychology, Functional illiteracy
Abstract

The purpose of this study was to further analyze the effects of education across different age ranges on neuropsychological test performance. Two different analyses were performed. The first analysis was conducted in order to pinpoint the impact of school attendance on neuropsychological testing. A group of 64 illiterate normal subjects was selected in the Mexican Republic. Their performance was compared with two barely schooled control groups (1-2 and 3-4 years of schooling). The subjects' ages ranged from 16 to 85 years. In the second analysis, the illiterate subjects were further matched by age and sex with individuals with 1 to 4, 5 to 9, and 10 to 19 years of formal education. The Spanish version of the NEUROPSI neuropsychological test battery (Ostrosky, Ardila, & Rosselli, 1997) was used. Results indicated a significant educational effect on most of the tests. Largest educational effect was noted in constructional abilities (copying of a figure), language (comprehension), phonological verbal fluency, and conceptual functions (similarities, calculation abilities, and sequences). Aging effect was noted in visuoperceptual (visual detection) and memory scores. In the first subject sample, it was evident that, despite using such limited educational range (from 0-4 years of formal education), and such a wide age range (from 16-85 years), schooling represented a stronger variable than age. It is proposed that education effect on neuropsychological test performance represents a negatively accelerated curve, tending to a plateau.

Published
2003

6. Sensitivity and specificity of the Mini-Mental State Examination in a Spanish-speaking population

Author

Alfredo Ardila, Gabriela López-Arango, and Feggy Ostrosky-Solís

Subjects
Gerontology, Adult, Male, Age effect, Mental Status Schedule, Adolescent, Low education, Population, Spanish speaking, Sensitivity and Specificity, Cognition, Developmental and Educational Psychology, medicine, Humans, education, Aged, Language, Aged, 80 and over, education.field_of_study, Mini–Mental State Examination, medicine.diagnostic_test, Age Factors, General Medicine, Hispanic or Latino, Middle Aged, Neuropsychology and Physiological Psychology, Educational Status, Female, Psychology, Demography
Abstract

The Mini-Mental State Examination (MMSE; Folstein, Folstein, & McHugh, 1975) was given to a total of 430 normal participants divided into 3 age ranges (16-50, 51-65, and 66-89) and 4 educational ranges (0, 1-4, 5-9, and ≧ 10 years). The educational level effect was notoriously stronger than the age effect. Normal illiterate participants obtained scores that would correspond to severe cognitive alterations (M = 17.67); low education participants (1-4 years) would be classified with moderate cognitive alterations (M = 20.61). Sensitivity and specificity of the MMSE were established. Low sensitivity and specificity were found for both the participants with 0 and 1 to 4 years of schooling, 50% and 72.73%, respectively. In participants with more than 5 years of schooling, the specificity (86.36%) and sensitivity (86.36%) indexes were higher. We concluded that the MMSE is an instrument with little diagnostic utility among participants with a low level of education.

Published
2000

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