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Introduction Constipation is a common clinical condition, particularly among cancer patients.

Abstract The frequency and severity of extreme events related to climate change have intensified worldwide in the last decades. It is documented that increasing extreme rainfall and flooding cause more nutrient runoff into waterbodies, initiating numerous harmful algal bloom (HAB) events, especially in fragile ecosystems. We analyze the dramatic economic damage of one of these episodes in Mar Menor, the largest salt-water lagoon in Europe. We show that when the public perceived the severity of environmental degradation, the return on housing investment was 43% lower in the surroundings than in similar neighboring zones 6 years after the HAB (2015). This represents a loss in housing wealth of more than 4000 million euros, around ten times the gains of changing from dry-farming to irrigated crops, which makes this ecosystem fragile. Hence, we quantify some of the economic consequences of ecological deterioration linked to episodes of Global Climate Change.

Con el objetivo de identificar la manera en que tienen lugar manifestaciones en torno a las masculinidades en una selección de perfiles mexicanos que publican contenidos en español tanto en Facebook como en TikTok, a partir de propuestas que se oponen a lo que Connell identifica como masculinidad hegemónica, se realizó un análisis de contenido sobre una muestra no probabilística de publicaciones y comentarios. Los principales resultados indican que las propuestas hechas en los sitios observados giran en torno a una paternidad participativa, dada en el contexto de relaciones de pareja respetuosas, con tolerancia a la diversidad sexo-genérica, resaltando además la libre expresión emocional como parte de un autocuidado que es tanto mental como físico. Algunas de las principales conclusiones sugieren que, a pesar de las resistencias a la estructura patriarcal que es posible observar en los espacios digitales estudiados, otras investigaciones revelan que sigue habiendo una gran cantidad de manifestaciones que manifiestan posiciones asimétricas de poder entre distintas identidades sexo-genéricas.

Summary: β-glucan is the major component of the extracellular matrix (ECM) of many fungi, including wood degrading fungi. Many of these species also secrete oxalate into the ECM. Our research demonstrates that β-glucan forms a novel, previously unreported, hydrogel at room temperature with oxalate. Oxalate was found to alter the rheometric properties of the β-glucan hydrogels, and modeling showed that β-glucan hydrogen bonds with oxalate in a non-covalent matrix. Change of oxalate concentration also impacted the diffusion of a high-molecular-weight protein through the gels. This finding has relevance to the diffusion of extracellular enzymes into substrates and helps to explain why some types of wood-decay fungi rely on non-enzymatic degradation schemes for carbon cycling. Further, this research has potential impact on the diffusion of metabolites in association with pathogenic/biomedical fungi.

The goal of this narrative review is to highlight the healthcare challenges faced by adults with cerebral palsy, including the management of long-term motor deficits, difficulty finding clinicians with expertise in these long-term impairments, and scarcity of rehabilitation options. Additionally, this narrative review seeks to examine potential methods for maintaining functional independence, promoting social integration, and community participation. Although the brain lesion that causes the movement disorder is non-progressive, the neurodevelopmental disorder worsens from secondary complications of existing sensory, motor, and cognitive impairments. Therefore, maintaining the continuum of care across one’s lifespan is of utmost importance. Advancements in healthcare services over the past decade have resulted in lower mortality rates and increased the average life expectancy of people with cerebral palsy. However, once they transition from adolescence to adulthood, limited federal and community resources, and health care professionals’ lack of expertise present significant obstacles to achieving quality healthcare and long-term benefits. This paper highlights the common impairments seen in adults with cerebral palsy. Additionally, it underscores the critical role of long-term healthcare and management to prevent functional decline and enhance quality of life across physical, cognitive, and social domains.

Abstract Minimizing environmental pollution from Tailings Storage Facilities (TSFs) is one of the key goals of the mining sector. While much attention is given to risks from potential catastrophic failures of large TSFs, there is also a need to assess risks due to noncatastrophic but more frequent releases of contaminants. In response to this need, this article proposes a method for prioritizing TSFs in terms of flood exposure, based on flood maps produced by the Shallow Water Integrated Flood Tool. The method was implemented using a case study of a flood event in the Copiapó city region (Atacama, Chile). A sensitivity analysis was carried out to evaluate the influence of different model configurations and input parameters. The results showed that 10% of all the TSFs in the case study region were exposed to flood waters due to the fluvial dynamics of the Copiapo River. Additionally, the sensitivity analysis revealed that in the event of extreme local precipitation, capable of generating runoff, up to 88% of all the TSFs could have some degree of flood exposure. The results also suggest that flood simulations using satellite‐derived terrain data at moderate resolution can be used for a preliminary large‐scale assessment of TSF flood exposure.

Eutypa dieback and Esca complex are fungal diseases of grape that cause large economic losses in vineyards. These diseases require, or are enhanced by, fungal consortia growth which leads to the deterioration of the wood tissue in the grapevine trunk; however, pathogenesis and the underlying mechanisms involved in the woody tissue degradation are not understood. We examined the role that the consortia fungal metabolome have in generating oxygen radicals that could potentially play a role in trunk decay and pathogenesis. Unique metabolites were isolated from the consortia fungi with some metabolites preferentially reducing iron whereas others were involved in redox cycling to generate hydrogen peroxide. Metabolite suites with different functions were produced when fungi were grown separately vs. when grown in consortia. Chelator-mediated Fenton (CMF) chemistry promoted by metabolites from these fungi allowed for the generation of highly reactive hydroxyl radicals. We hypothesize that this mechanism may be involved in pathogenicity in grapevine tissue as a causal mechanism associated with trunk wood deterioration/necrosis in these two diseases of grape.

The purpose of this study was to evaluate the inter-device reliability of three VERT devices (Mayfonk Athletic, Florida, USA) when worn on the waist (W), left-hip (LH), and right-hip (RH) during single- and double-leg counter movement jumps (CMJ) in collegiate athletes. Thirty-two female and twenty-eight male NCAA Division II athletes (n = 60) participated in the present study. Jump height (JH) values for double-leg CMJs were analyzed by each device using a one-way repeated measures ANOVA whereas a 2 (jump leg) x 3 (wear location) repeated measures ANOVA was employed to evaluate single-leg CMJs. Reliability of the VERT devices were based upon intraclass correlation coefficients (ICC). Double-leg CMJs revealed an excellent ICC between all three VERT devices (ICC = 0.969). However, JH for RH and LH (45.69 ± 9.84 and 45.82 ± 10.45 cm, respectively) were on average lower than W (50.44 ± 12.37cm; both p LH for left-leg CMJs; all p

We report on a chemo-dynamical analysis of SPLUS J142445.34−254247.1 (SPLUS J1424−2542), an extremely metal-poor halo star enhanced in elements formed by the rapid neutron-capture process ( r -process). This star was first selected as a metal-poor candidate from its narrowband S-PLUS photometry and followed up spectroscopically in medium resolution with Gemini-South/GMOS, which confirmed its low-metallicity status. High-resolution spectroscopy was gathered with GHOST at Gemini-South, allowing for the determination of the chemical abundances for 36 elements, from carbon to thorium. At [Fe/H] = −3.39, SPLUS J1424−2542 is one of the lowest-metallicity stars with measured Th and has the highest $\mathrm{log}\epsilon (\mathrm{Th}/\mathrm{Eu})$ observed to date, making it part of the “actinide-boost” category of r -process–enhanced stars. The analysis presented here suggests that the gas cloud from which SPLUS J1424−2542 formed must have been enriched by at least two progenitor populations. The light-element ( Z ≤ 30) abundance pattern is consistent with the yields from a supernova explosion of metal-free stars with 11.3–13.4 M _⊙ , and the heavy-element ( Z ≥ 38) abundance pattern can be reproduced by the yields from a neutron star merger (1.66 M _⊙ and 1.27 M _⊙ ) event. A kinematical analysis also reveals that SPLUS J1424−2542 is a low-mass, old halo star with a likely in situ origin, not associated with any known early merger events in the Milky Way.

The Gemini High-resolution Optical SpecTrograph (GHOST) is the newest high-resolution spectrograph to be developed for a large-aperture telescope, recently deployed and commissioned at the Gemini-South telescope. In this paper, we present the first science results from the GHOST spectrograph taking during its commissioning runs. We have observed the bright metal-poor benchmark star HD 122563, along with two stars in the ultrafaint dwarf galaxy Reticulum II (Ret ii ), one of which was previously identified as a candidate member, but did not have a previous detailed chemical abundance analysis. We find that this candidate (GDR3 0928) to be a bona fide member of Ret ii , and from a spectral synthesis analysis it is also revealed to be a CEMP- r star, with significant enhancements in several light elements (C, N, O, Na, Mg, and Si), in addition to featuring an r -process enhancement like many other Ret ii stars. The light-element enhancements in this star resemble the abundance patterns seen in the CEMP-no stars of other ultrafaint dwarf galaxies, and are thought to have been produced by an independent source from the r -process. These unusual abundance patterns are thought to be produced by faint supernovae, which may be produced by some of the earliest generations of stars.

Fomitiporia mediterranea M. Fisch. (Fmed) is a basidiomycete first described in 2002, and was considered up to then as part of Fomitiporia punctata (P. Karst) Murrill. This fungus can degrade lignocellulosic biomass, causing white rot and leaving bleached fibrous host residues. In Europe Fmed is considered the main grapevine wood rot (Esca) agent within the Esca disease complex, which includes some of the most economically important Grapevine Trunk Diseases (GTDs). This review summarises and evaluates published research on Fmed, on white rot elimination by curettage or management by treatments with specific products applied to diseased grapevines, and on the relationship between wood symptoms and Grapevine Leaf Stripe Disease (GLSD) in the Esca disease complex. Information is also reviewed on the fungus biology, mechanisms of pathogenicity, and their possible relationships with external foliar symptoms of the Esca disease complex. Information on Fmed control strategies is also reviewed.

Although many neuropsychiatric risk genes are known to contribute to epigenetic regulation of gene expression, very little is known about specific chromatin-associated mechanisms that govern the formation and maintenance of neuronal connectivity. Here, the authors report that transcallosal connectivity is critically dependent on C11orf46/ARL14EP, a nuclear protein encoded in the chromosome 11p13 WAGR risk locus, and that RNA-guided epigenetic editing of hyperexpressed Sema6a gene promoters in C11orf46-knockdown neurons resulted in normalization of expression and rescue of transcallosal dysconnectivity via repressive chromatin remodeling.

La enfermedad aterosclerótica de la aorta constituye una de las causas cardiovasculares de embolia. La prevalencia de ésta patología constituye un indicador de peor pronóstico, en particular, en caso de debrís aórtico. El debrís aórtico está constituido por una placa ateromatosa complicada con un trombo móvil adherido. Presentamos el caso de un paciente de 58 años que presentó episodios reiterados de accidentes cerebrovasculares isquémicos.

This paper proposes a new version of the Spain-STING (Spain, Short-Term INdicator of Growth), a dynamic factor model used by the Banco de España for the short-term forecasting of the Spanish economy. The extended and revised version of the Spain-STING presented in this document includes a forecast for each of the demand components of the National Accounts. In order to select the indicators that best estimate the Spanish GDP and its demand components, several models are considered. Following this strategy, the selected models are those in which the common factor explains the highest proportion of the variance of the GDP. These models allow us to forecast GDP, private consumption, public expenditure, investment in capital goods, construction investment, exports and imports in a consistent way. We assess the predictive power of the models for GDP and its demand components for the period 2005–2017. With regard to the GDP forecast, we find some improvement of the predictive power compared to the previous version of Spain-STING. As for the demand components, we show that our proposal has better predictive power than other possible time series models.

For several decades, researchers and marketing practitioners have proclaimed that the adoption of a consumer-oriented philosophy is the key to developing and maintaining a sustainable competitive advantage for a business operating in a highly competitive environment. The interest shown has not been sufficient to dispel certain concerns about the construct’s domain, and the methodology followed for measuring it in different cultural contexts. This paper examines the reliability and validity of three scales for measuring market orientation in a Spanish-speaking international context. The results confirm those obtained from previous research efforts. The study of the three scales, when combined, suggests the existence of six dimensions that are measurable with eighteen items.

BackgroundResistance to cephalosporins in Enterobacteriaceae is mainly due to the production of extended-spectrum beta-lactamase (ESBL). Little is known about ESBL-producing bacteria in Bangladesh. Therefore, the study presents results of phenotypic and molecular characterization of ESBL-producing Escherichia coli from hospitals in Bangladesh.MethodsA total of 339 E. coli isolated from patients with urinary tract and wound infections attending three different medical hospitals in urban and rural areas of Bangladesh between 2003-2007 were screened for ESBL-production by the double disk diffusion test. Isolates with ESBL-phenotype were further characterized by antibiotic susceptibility testing, PCR and sequencing of different β-lactamase and virulence genes, serotyping, and XbaI-macrorestriction followed by pulsed-field gel electrophoresis (PFGE).ResultsWe identified 40 E. coli with ESBL phenotype. These isolates were resistant to ceftriaxone, ceftazidime, cefotaxime, aztreonam, cefepime, and nalidixic acid but remained susceptible to imipenem. All but one isolate were additionally resistant to ciprofloxacin, and 3 isolates were resistant to cefoxitin. ESBL genes of blaCTX-M-1-group were detected in all isolates; blaTEM-type and blaOXA-1-type genes were detected in 33 (82.5%) and 19 (47.5%) isolates, respectively. Virulence genes that are present in diarrhoeagenic E. coli were not found. Class-1 integron was present in 20 (50%) isolates. All the ESBL-producing E. coli isolates harbored plasmids ranging between 1.1 and 120 MDa. PFGE-typing revealed 26 different pulsotypes, but identical pulsotype showed 6 isolates of serotype O25:H4.ConclusionThe prevalence of multidrug-resistant ESBL-producing E. coli isolates appears to be high and the majority of the isolates were positive for blaCTX-M. Although there was genetic heterogeneity among isolates, presence of a cluster of isolates belonging to serotype O25:H4 indicates dissemination of the pandemic uropathogenic E. coli clone in Bangladesh.

Although microarthropods dominate forest floor faunas in both diversity and abundance, long-term aspects of forest cycles have been widely neglected in soil ecological research in the past. We studied which modifications occurred within collembolan assemblages during a typical beech forest cycle from the north-western part of France. We selected 16 sites representative for four age-classes: 15-year, 65-year, 90-year and 130-year-old stands. Strongly significant effects of the factor ‘age class’ reflect increasing collembolan abundance, biomass and mean species richness throughout the ageing of the forest. However, none of the species could be depicted as an indicator for a specific age-class. Nevertheless, shifts in the relative abundances of dominant or subdominant species were responsible for significant differences between communities of the four successional stages. Our results differ from previous studies, highlighting on the one hand the multiplicity of factors acting on soil invertebrates, and on the other hand the need for forest management aiming at combining productivity and biodiversity conservation to adapt to regional differences in tree species, soil, substrate and climatic conditions.

Take a family of independent events. If some of these events, or all of them, are replaced by their complements, then independence still holds. This fact, which is agreed upon by the members of the statistical/probability communities, is tremendously well known, is fairly intuitive and has always been frequently used for easing probability calculations and allowing important developments in probability theory. However, can this result be proven without advanced elements from probability theory, such as independent s-fields and related results? This paper aims primarily to fill this possible gap. Two elementary proofs that require only introductory probability content are given in detail and compared with the 'technical' proof found in books on advanced probability theory. A discussion regarding how these proofs could be included in regular probability courses is also included in the survey.

Within the framework of the enlargement methodological proposed by the thinker Arturo Roig, we expose the need for a Latin American symbolic or semiotic and we unravel Roigean symbol theory, in its double facet: axiology and normativity. Then, we reflect on the distinction between signification and meaning that allows us to open ourselves to the metaphorical system implicit in words as semantic marks. Subsequently, we explain the characteristics of the symbolic universe: conflict, discursive dualism and reversal, in order to show the Roigean interpretation of Caliban as an example of reversal of the symbolic function. Subsequently, we delve into the feminist interpretation of the Sycorax figure as a symbol of resistance and liberation. Finally, we highlight the importance of the scarf as a symbol and the struggle of women in their relentless struggle for their rights. [ABSTRACT FROM AUTHOR]