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9. International Diabetes Federation Position Statement on the 1-hour post-load plasma glucose for the diagnosis of intermediate hyperglycaemia and type 2 diabetes

Author

Bergman, Michael, primary, Manco, Melania, additional, Satman, Ilhan, additional, Chan, Juliana, additional, Schmidt, Maria Inês, additional, Sesti, Giorgio, additional, Vanessa Fiorentino, Teresa, additional, Abdul-Ghani, Muhammad, additional, Jagannathan, Ram, additional, Kumar Thyparambil Aravindakshan, Pramod, additional, Gabriel, Rafael, additional, Mohan, Viswanathan, additional, Buysschaert, Martin, additional, Bennakhi, Abdullah, additional, Pascal Kengne, Andre, additional, Dorcely, Brenda, additional, Nilsson, Peter M., additional, Tuomi, Tiinamaija, additional, Battelino, Tadej, additional, Hussain, Akhtar, additional, Ceriello, Antonio, additional, and Tuomilehto, Jaakko, additional

Published
2024
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12. A Bayesian Network for Probabilistic Reasoning and Imputation of Missing Risk Factors in Type 2 Diabetes

Author

Sambo, Francesco, Facchinetti, Andrea, Hakaste, Liisa, Kravic, Jasmina, Di Camillo, Barbara, Fico, Giuseppe, Tuomilehto, Jaakko, Groop, Leif, Gabriel, Rafael, Tiinamaija, Tuomi, Cobelli, Claudio, Goebel, Randy, Series editor, Tanaka, Yuzuru, Series editor, Wahlster, Wolfgang, Series editor, Holmes, John H., editor, Bellazzi, Riccardo, editor, Sacchi, Lucia, editor, and Peek, Niels, editor

Published
2015
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14. La Administración Militar en El Salvador: 1992-2022

Author

Molina Gabriel, Rafael Antonio, Martínez, Rafael, 1965, and Universitat de Barcelona. Facultat de Dret

Subjects
Military administration, Administració militar, Civil-military relations, 1992-2022, El Salvador, Relacions poder civil-poder militar, Forces armades, Armed Forces
Abstract

[spa] El Salvador registra una historia de regímenes militares (1932-1979) y de guerra civil (1980-1992). Después de treinta años de la firma de la paz, el sector defensa ha sido gestionado solo con las reformas de la transición política, dando por sentado que el tema militar desaparecía con la democracia. Esto redujo las relaciones civiles-militares en El Salvador al control civil en detrimento de los otros elementos que la componen. Por lo tanto, la presente investigación pretende analizar los elementos que caracterizan las relaciones civiles-militar para detallar cuánto se ha recorrido y cómo ha sido el avance del proceso de consolidación democrática de éstas a partir de los Acuerdos de Paz, y cuáles han sido sus reformas. Esto permitirá saber si las relaciones civiles militares en El Salvador han logrado convertir a la Fuerza Armada en una administración militar al servicio del Estado y la sociedad, porque, de otra manera, se estaría permitiendo grados de autonomía y, quizá, de poder a los militares que sería inaceptable en democracia., [eng] El Salvador records a history of military regimes (1932-1979) and civil war (1980-1992). In the thirty years since the signing of the peace accords, the defense sector has been exclusively managed with the reforms implemented during the political transition, under the assumption that military-security issues would vanish with the advent of democracy. As a result, civil-military relations (CMR) in El Salvador were relegated to civilian control to the detriment of the other elements of CMR. Thus, this research intends to analyze the features that define civil-military relations to identify how far the process of democratic consolidation has progressed since the Peace Accords, and which reforms have since been implemented. This will allow us to determine the extent to which civil-military relations in El Salvador have succeeded in converting the Armed Forces into a military administration that serves the State and society, because otherwise, the military would be granted a degree of autonomy and, perhaps, a level of power that would be unacceptable for democracy., [cat] El Salvador registra una història de règims militars (1932-1979) i de guerra civil (1980-1992). Després de trenta anys de la signatura de la pau, el sector defensa ha estat gestionat només amb les reformes de la transició política, donant per fet que el tema militar desapareixia amb la democràcia. Això va reduir les relacions civils-militars a El Salvador al control civil en detriment dels altres elements que la componen. Per tant, aquesta investigació pretén analitzar els elements que caracteritzen les relacions civils militar per detallar quant s'ha recorregut i com ha estat l'avenç del procés de consolidació democràtica d'aquestes a partir dels Acords de Pau, i quins n'han estat reformes. Això permetrà saber si les relacions civils militars a El Salvador han aconseguit convertir la Força Armada en una administració militar al servei de l'Estat i la societat, perquè, altrament, s'estaria permetent graus d'autonomia i, potser, de poder als militars que seria inacceptable en democràcia.

Published
2023

16. EPMA-World Congress 2015: Bonn, Germany. 3-5 September 2015

Author

Abraham, Jella-Andrea, Golubnitschaja, Olga, Akhmetov, Ildar, Andrews, Russell J., Quintana, Leonidas, Andrews, Russell J., Baban, Babak, Liu, Jun Yao, Qin, Xu, Wang, Tailing, Mozaffari, Mahmood S., Bati, Viktoriia V., Meleshko, Tamara V., Levchuk, Olga B., Boyko, Nadiya V., Bauer, Joanna, Boerner, Ewa, Podbielska, Halina, Bomba, Alojz, Petrov, Viktor O., Drobnych, Volodymyr G., Bubnov, Rostyslav V., Bykova, Oksana M., Boyko, Nadiya V., Brunner-La Rocca, Hans-Peter, Fleischhacker, Lutz, Golubnitschaja, Olga, Heemskerk, Frank, Helms, Thomas, Jaarsma, Tiny, Kinkorová, Judita, Ramaekers, Jan, Ruff, Peter, Schnur, Ivana, Vanoli, Emilio, Verdu, Jose, Brunner-La Rocca, Hans-Peter, Bubnov, Rostyslav V., Grabovetskyi, Sergiy A., Mykhalchenko, Olena M., Tymoshok, Natalia O., Shcherbakov, Oleksandr B., Semeniv, Igor P., Spivak, Mykola Y., Bubnov, Rostyslav V., Ostapenko, Tetyana V., Bubnov, Rostyslav V., Kobyliak, Nazarii M., Zholobak, Nadiya M., Spivak, Mykola Ya., Cauchi, John Paul, Cherepakhin, Dmitrii, Bakay, Marina, Borovikov, Artem, Suchkov, Sergey, Cieślik, Barbara, Migasiewicz, Agnieszka, Podbielska, Maria-Luiza, Pelleter, Markus, Giemza, Agnieszka, Podbielska, Halina, Cirak, Sebahattin, Del Re, Marzia, Bordi, Paola, Citi, Valentina, Palombi, Marta, Pinto, Carmine, Tiseo, Marcello, Danesi, Romano, Einhorn, Lukas, Fazekas, Judit, Muhr, Martina, Schoos, Alexandra, Panakova, Lucia, Herrmann, Ina, Manzano-Szalai, Krisztina, Oida, Kumiko, Fiebiger, Edda, Singer, Josef, Jensen-Jarolim, Erika, Elnar, Arpiné A., Ouamara, Nadia, Boyko, Nadiya, Coumoul, Xavier, Antignac, Jean-Philippe, Le Bizec, Bruno, Eppe, Gauthier, Renaut, Jenny, Bonn, Torsten, Guignard, Cédric, Ferrante, Margherita, Chiusano, Maria Liusa, Cuzzocrea, Salvatore, O’Keeffe, Gerard, Cryan, John, Bisson, Michelle, Barakat, Amina, Hmamouchi, Ihsane, Zawia, Nasser, Kanthasamy, Anumantha, Kisby, Glen E., Alves, Rui, Pérez, Oscar Villacañas, Burgard, Kim, Spencer, Peter, Bomba, Norbert, Haranta, Martin, Zaitseva, Nina, May, Irina, Grojean, Stéphanie, Body-Malapel, Mathilde, Harari, Florencia, Harari, Raul, Yeghiazaryan, Kristina, Golubnitschaja, Olga, Calabrese, Vittorio, Nemos, Christophe, Soulimani, Rachid, Evsevyeva, Maria E., Mishenko, Elena A., Kumukova, Zurida V., Chudnovsky, Evgeniy V., Smirnova, Tatyana A., Evsevyeva, Maria E., Ivanova, Ludmila V., Eremin, Michail V., Rostovtseva, Maria V., Evsevyeva, Maria E., Eremin, Michail V., Koshel, Vladimir I., Sergeeva, Oksana V., Konovalova, Nadesgda M., Girotra, Shantanu, Golubnitschaja, Olga, Golubnitschaja, Olga, Debald, Manuel, Kuhn, Walther, Yeghiazaryan, Kristina, Bubnov, Rostyslav V., Goncharenko, Vadym M., Lushchyk, Ulyana, Grech, Godfrey, Konieczka, Katarzyna, Golubnitschaja, Olga, Erwich, Jan Jaap, Costigliola, Vincenzo, Yeghiazaryan, Kristina, Gembruch, Ulrich, Goncharenko, Vadym M., Beniuk, Vasyl O., Kalenska, Olga V., Bubnov, Rostyslav V., Goncharenko, Vadym M., Beniuk, Vasyl O., Bubnov, Rostyslav V., Melnychuk, Olga, Gorbacheva, Irina A., Orekhova, Lyudmila Y., Tachalov, Vadim V., Grechanyk, Olena I., Abdullaiev, Rizvan Ya., Bubnov, Rostyslav V., Hagan, Suzanne, Martin, Eilidh, Pearce, Ian, Oliver, Katherine, Haytac, Cenk, Salimov, Fariz, Yoksul, Servin, Kunin, Anatoly A., Moiseeva, Natalia S., Herrera-Imbroda, Bernardo, del Río-González, Sergio, Lara, Maria Fernanda, Angulo, Antonia, Machuca Santa-Cruz, Francisco Javier, Herrera-Imbroda, Bernardo, del Río-González, Sergio, Lara, Maria Fernanda, Ionescu, John, Isamulaeva, Alfiya Z., Kunin, Anatoly A., Magomedov, Shamil Sh., Isamulaeva, Aida I., Josifova, Tatjana, Kapalla, Marko, Kubáň, Juraj, Golubnitschaja, Olga, Costigliola, Vincenzo, Costigliola, Vincenzo, Kapalla, Marko, Kubáň, Juraj, Golubnitschaja, Olga, Kent, Anthony, Fisher, Tom, Dias, Tilak, Kinkorová, Judita, Topolčan, Ondřej, Kohl, Matthias, Kunin, Anatoly A., Moiseeva, Natalia S., Kurchenko, Andrii I., Beniuk, Vasyl A., Goncharenko, Vadym M., Bubnov, Rostyslav V., Boyko, Nadiya V., Strokan, Andriy M., Kzhyshkowska, Julia, Gudima, Alexandru, Stankevich, Ksenia S., Filimonov, Victor D., Klüter, Harald, Mamontova, Evgeniya M., Tverdokhlebov, Sergei I., Lushchyk, Ulyana B., Novytskyy, Viktor V., Babii, Igor P., Lushchyk, Nadiya G., Riabets, Lyudmyla S., Legka, Ivanna I., Marcus-Kalish, Mira, Mitelpunkt, Alexis, Galili, Tal, Shachar, Neta, Benjamini, Yoav, Migasiewicz, Agnieszka, Pelleter, Markus, Bauer, Joanna, Dereń, Ewelina, Podbielska, Halina, Moiseeva, Natalia S., Kunin, Anatoly A., Kunin, Dmitry A., Moiseeva, Natalia S., Ippolitov, Yury A., Kunin, Dmitry A., Morozov, Alexei N., Chirkova, Natalia V., Aliev, Nakhid T., Mozaffari, Mahmood S., Liu, Jun Yao, Baban, Babak, Mozaffari, Mahmood S., Liu, Jun Yao, Abdelsayed, Rafik, Shi, Xing-Ming, Baban, Babak, Novák, Jaroslav, Štork, Milan, Zeman, Václav, Oosterhuis, Wytze P., Theodorsson, Elvar, Orekhova, Lyudmila Y., Kudryavtseva, Tatyana V., Isaeva, Elena R., Tachalov, Vadim V., Loboda, Ekaterina S., Pazzagli, Mario, Malentacchi, Francesca, Mancini, Irene, Brandslund, Ivan, Vermeersch, Pieter, Schwab, Matthias, Marc, Janja, van Schaik, Ron H. N., Siest, Gerard, Theodorsson, Elvar, Di Resta, Chiara, Pleva, Matus, Juhar, Jozef, Pleva, Matus, Juhar, Jozef, Polívka jr., Jiří, Janků, Filip, Pešta, Martin, Doležal, Jan, Králíčková, Milena, Polívka, Jiří, Polívka, Jiří, Lukešová, Alena, Müllerová, Nina, Ševčík, Petr, Rohan, Vladimír, Richter, Kneginja, Miloseva, Lence, Niklewski, Günter, Richter, Kneginja, Acker, Jens, Niklewski, Guenter, Safonicheva, Olga, Costigliola, Vincenzo, Safonicheva, Olga, Sautin, Maxim, Sinelnikova, Janna, Suchkov, Sergey, Secer, Songül, von Bandemer, Stephan, Shapira, Niva, Shcherbakov, Aleksandr, Kunin, Anatoly A., Moiseeva, Natalia S., Shumilovich, Bogdan R., Lipkind, Zhanna, Vorobieva, Yulia, Kunin, Dmitry A., Sudareva, Anastasiia V., Smokovski, Ivica, Milenkovic, Tatjana, Solís-Herrera, Arturo, Arias-Esparza, María del Carmen, Suchkov, Sergey, Sridhar, Krishna Chander, Golubnitschaja, Olga, Studneva, Maria, Song, Sihong, Creeden, James, Мandrik, Мark, Suchkov, Sergey, Theodorsson, Elvar, Tofail, Syed A. M., Topolčan, Ondřej, Kinkorová, Judita, Fiala, Ondřej, Karlíková, Marie, Svobodová, Šárka, Kučera, Radek, Fuchsová, Radka, Třeška, Vladislav, Šimánek, Václav, Pecen, Ladislav, Šoupal, Jan, Svačina, Štěpán, Tretyak, Evgeniya, Studneva, Maria, Suchkov, Sergey, Trovato, Francesca M., Martines, Giuseppe Fabio, Brischetto, Daniela, Catalano, Daniela, Musumeci, Giuseppe, Trovato, Guglielmo M., Tsangaris, George Th., Anagnostopoulos, Athanasios K., Tsangaris, George Th., Anagnostopoulos, Athanasios K., Verdú, José, Gutiérrez, German, Rovira, Jordi, Martinez, Marta, Fleischhacker, Lutz, Green, Donna, Garson, Arthur, Tamburini, Elena, Cuomo, Stefano, Martinez-Leon, Juan, Abrisqueta, Teresa, Brunner-La Rocca, Hans-Peter, Jaarsma, Tiny, Arredondo, Teresa, Vera, Cecilia, Fico, Giuseppe, Golubnitschaja, Olga, Arribas, Fernando, Onderco, Martina, Vara, Isabel, Verdú, José, Sambo, Francesco, Di Camillo, Barbara, Cobelli, Claudio, Facchinetti, Andrea, Fico, Giuseppe, Bellazzi, Riccardo, Sacchi, Lucia, Dagliati, Arianna, Segnani, Daniele, Tibollo, Valentina, Ottaviano, Manuel, Gabriel, Rafael, Groop, Leif, Postma, Jacqueline, Martinez, Antonio, Hakaste, Liisa, Tuomi, Tiinamaija, Zarkogianni, Konstantia, Volchek, Igor, Pototskaya, Nina, Petrov, Andrey, Volchek, Igor, Pototskaya, Nadezhda, Petrov, Andrey, Voog-Oras, Ülle, Jagur, Oksana, Leibur, Edvitar, Niibo, Priit, Jagomägi, Triin, Nguyen, Minh Son, Pruunsild, Chris, Piikov, Dagmar, Saag, Mare, Wang, Wei, Wang, Wei, Weinhäusel, Andreas, Pulverer, Walter, Wielscher, Matthias, Hofner, Manuela, Noehammer, Christa, Soldo, Regina, Hettegger, Peter, Gyurjan, Istvan, Kulovics, Ronald, Schönthaler, Silvia, Beikircher, Gabriel, Kriegner, Albert, Pabinger, Stephan, Vierlinger, Klemens, Yüzbaşıoğlu, Ayşe, Özgüç, Meral, EFLM, on behalf of ZENITH consortium, and on behalf of MOSAIC consortium

Published
2016
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17. Single cell transcriptomic profiling of human brain organoids reveals developmental timing- and cell-type-specific vulnerabilities induced by NRXN1 CNVs in schizophrenia

Author

Sebastian, Rebecca, primary, Jin, Kang, additional, Pavon, Narciso, additional, Bansal, Ruby, additional, Potter, Andrew, additional, Song, Yoonjae, additional, Babu, Juliana, additional, Gabriel, Rafael, additional, Sun, Yubing, additional, Aronow, Bruce, additional, and Pak, ChangHui, additional

Published
2022
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18. Adubação nitrogenada em cobertura: fator determinante para elevadas produtividades de feijão comum

Author

Indianara Cazuza do Nascimento, Paulo Henrique Alves Morais, Dayane Barbosa Pereira, Luiz Cobiniano de Melo Filho, Ítallo Diego de Souza, Ivanildo Guilherme Henrique, and Gabriel Rafael de Andrade

Subjects
General Medicine
Abstract

Considerando a grande exigência do feijoeiro em nutrientes, destaca-se a alta demanda da cultura por nitrogênio (N). Dessa maneira, objetivou-se avaliar se a inoculação de sementes, com Azospirillum brasilense e adubação nitrogenada e molíbdica, em cobertura, influenciam os caracteres agronômicos e o rendimento produtivo do feijão comum. Para tanto, empregou-se o delineamento experimental de blocos casualizados, em esquema fatorial 2x2x2, com quatro repetições. Avaliou-se a inoculação de sementes (sem inoculação e com inoculação de A. brasilense), aplicação foliar de molibdênio (sem aplicação e com aplicação de 126 g ha-1) e fornecimento de nitrogênio em cobertura (sem aplicação e com aplicação de 30 kg ha-1). Os ensaios foram conduzidos no município de Colorado do Oeste, Rondônia, nos anos de 2017 e 2018, adotando sistema de semeadura direta. Utilizou-se a cultivar BRS Estilo e para inoculação das sementes as estirpes AbV5 e AbV6 com 2x108 Ufc g-1. O molibdênio foliar foi aplicado, em dose única, aos 19 dias após a emergência das plântulas e o nitrogênio, fornecido por ocasião da fase de desenvolvimento reprodutivo R5, utilizando como fonte a ureia, aplicada manualmente na linha de plantio. A inoculação das sementes de feijão, com A. brasilense, resulta em aumento da produtividade quando associada a adubação nitrogenada em cobertura. A adubação nitrogenada em cobertura é determinante no aumento de produtividade do feijão comum.

Published
2021
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23. Gadolinium(Iii) Oxide Nanoparticles Conjugated with Amylovis® with Applications in the Early Detection of Alzheimer's Disease. Part Ii

Author

Guerrero-Porras, Gabriel Rafael, primary, Díaz-García, Alicia M., additional, González-Dalmau, Evelio R., additional, Hernández-Rodríguez, Armando J., additional, Reyes-Molina, Israel, additional, Musacchio-Lasa, Alexis, additional, Espinosa-Rodríguez, Luis A., additional, Rodriguez-Tanty, Chryslaine, additional, and Sablón-Carrazana, Marquiza, additional

Published
2022
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24. Reduction in the Risk of Peripheral Neuropathy and Lower Decrease in Kidney Function with Metformin, Linagliptin or Their Fixed-Dose Combination Compared to Placebo in Prediabetes: A Randomized Controlled Trial.

Author

Gabriel, Rafael, Boukichou-Abdelkader, Nisa, Gilis-Januszewska, Aleksandra, Makrilakis, Konstantinos, Gómez-Huelgas, Ricardo, Kamenov, Zdravko, Paulweber, Bernhard, Satman, Ilhan, Djordjevic, Predrag, Alkandari, Abdullah, Mitrakou, Asimina, Lalic, Nebojsa, Egido, Jesús, Más-Fontao, Sebastián, Calvet, Jean Henri, Pastor, José Carlos, Lindström, Jaana, Lind, Marcus, Acosta, Tania, and Silva, Luis

Subjects
*PERIPHERAL neuropathy, *KIDNEY physiology, *RANDOMIZED controlled trials, *METFORMIN, *LINAGLIPTIN
Abstract

Objective: To compare the effect of glucose-lowering drugs on peripheral nerve and kidney function in prediabetes. Methods: Multicenter, randomized, placebo-controlled trial in 658 adults with prediabetes treated for 1 year with metformin, linagliptin, their combination or placebo. Endpoints are small fiber peripheral neuropathy (SFPN) risk estimated by foot electrochemical skin conductance (FESC < 70 μSiemens) and estimated glomerular filtration rate (eGFR). Results: Compared to the placebo, the proportion of SFPN was reduced by 25.1% (95% CI:16.3–33.9) with metformin alone, by 17.3% (95% CI 7.4–27.2) with linagliptin alone, and by 19.5% (95% CI 10.1–29.0) with the combination linagliptin/metformin (p < 0.0001 for all comparisons). eGFR remained +3.3 mL/min (95% CI: 0.38–6.22) higher with the combination linagliptin/metformin than with the placebo (p = 0.03). Fasting plasma glucose (FPG) decreased more with metformin monotherapy −0.3 mmol/L (95%CI: −0.48; 0.12, p = 0.0009) and with the combination metformin/linagliptin −0.2 mmol/L (95% CI: −0.37; −0.03) than with the placebo (p = 0.0219). Body weight (BW) decreased by −2.0 kg (95% CI: −5.65; −1.65, p = 0.0006) with metformin monotherapy, and by −1.9 kg (95% CI: −3.02; −0.97) with the combination metformin/linagliptin as compared to the placebo (p = 0.0002). Conclusions: in people with prediabetes, a 1 year treatment with metformin and linagliptin, combined or in monotherapy, was associated with a lower risk of SFPN, and with a lower decrease in eGFR, than treatment with placebo. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Carotid Intima-Media Thickness Progression and Risk of Vascular Events in People With Diabetes: Results From the PROG-IMT Collaboration

Author

Lorenz, Matthias W., Price, Jackie F., Robertson, Christine, Bots, Michiel L., Polak, Joseph F., Poppert, Holger, Kavousi, Maryam, Dörr, Marcus, Stensland, Eva, Ducimetiere, Pierre, Ronkainen, Kimmo, Kiechl, Stefan, Sitzer, Matthias, Rundek, Tatjana, Lind, Lars, Liu, Jing, Bergström, Göran, Grigore, Liliana, Bokemark, Lena, Friera, Alfonsa, Yanez, David, Bickel, Horst, Ikram, M. Arfan, Völzke, Henry, Johnsen, Stein Harald, Empana, Jean Philippe, Tuomainen, Tomi-Pekka, Willeit, Peter, Steinmetz, Helmuth, Desvarieux, Moise, Xie, Wuxiang, Schmidt, Caroline, Norata, Giuseppe D., Suarez, Carmen, Sander, Dirk, Hofman, Albert, Schminke, Ulf, Mathiesen, Ellisiv, Plichart, Matthieu, Kauhanen, Jussi, Willeit, Johann, Sacco, Ralph L., McLachlan, Stela, Zhao, Dong, Fagerberg, Björn, Catapano, Alberico L., Gabriel, Rafael, Franco, Oscar H., Bülbül, Alpaslan, Scheckenbach, Frank, Pflug, Anja, Gao, Lu, and Thompson, Simon G.

Published
2015
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29. Cardiovascular risk in the elderly population of Spain: the EPICARDIAN risk score

Author

Gabriel, Rafael, Muñiz, Javier, Vega, Saturio, Moral, Irene, Pérez-Castro, Teresa-Rosalía, Rodríguez-Salvanés, Francisco, Suárez, C., Novella, Blanca, Brotons, Carlos, Gabriel, Rafael, Muñiz, Javier, Vega, Saturio, Moral, Irene, Pérez-Castro, Teresa-Rosalía, Rodríguez-Salvanés, Francisco, Suárez, C., Novella, Blanca, and Brotons, Carlos

Abstract

[Abstract] Background and objectives: Cardiovascular risk estimation in people over 70 years of age is problematic. Most scores have been created based on cohorts of middle-aged people, with an underrepresentation of older adults. The predictive power of classical cardiovascular risk factors declines with age. The aim of this work is to develop a specific score for estimating cardiovascular risk among the elderly population in Spain. Methods: This work is a population-based cohort established in 1995. Setting: Three geographical areas of Spain (Madrid, Ávila, and Lugo). Participants: 3,729 people older than 64 years with no cardiovascular diseases (CVD) at baseline. Measurements: Suspected fatal and nonfatal CVD (both coronary heart disease and stroke) were investigated annually and confirmed using the WHO-MONICA criteria. All participants were followed-up on until occurrence of a first CVD event, until death, or until December 31, 2015. Results: Age was the strongest predictor of CVD at 10 years in both men and women. In men, variables associated with CVD were high blood pressure treatment (HR: 1.35; 95% CI: 1.067-1.710), diabetes (HR: 1.359; 95% CI: 0.997-1.852), and smoking (HR: 1.207; 95% CI: 0.945-1.541) and in women, the variables were smoking (HR: 1.881; 95% CI: 1.356-2.609) and diabetes (HR: 1.285; 95% CI: 0.967-1.707). Total cholesterol did not increase the risk of CVD in men or women. However, total cholesterol levels >200 mg/dL were inversely associated with 10-year risk of CVD in men and women. Conclusions: In elderly Spanish men, total CVD at 10 years is significantly increased by age, diabetes, and antihypertensive treatment and in elderly Spanish women by diabetes and smoking. Total cholesterol levels did not increase the risk of CVD, particularly in males., [Resumen] Antecedentes y objetivos. La estimación del riesgo cardiovascular en personas mayores de 70 años es problemática. La mayoría de las escalas se han creado basándose en cohortes de personas de mediana edad, con una representación insuficiente de los adultos de más edad. El poder predictivo de los factores de riesgo cardiovascular clásicos disminuye con la edad. El objetivo de este estudio es desarrollar una escala específica para estimar el riesgo cardiovascular de la población anciana española. Métodos. Este estudio se realizó en una cohorte poblacional establecida en 1995. Marco: tres zonas geográficas de España (Madrid, Ávila y Lugo). Participantes: 3.729 personas mayores de 64 años sin enfermedades cardiovasculares (ECV) al inicio del seguimiento. Mediciones: Se investigaron anualmente las sospechas de ECV mortal y no mortal (cardiopatía coronaria e ictus) y se confirmaron usando los criterios del proyecto MONICA de la OMS. Se siguió a todos los participantes hasta que apareció el primer episodio de ECV, hasta su muerte o hasta el 31 de diciembre de 2015. Resultados. La edad fue el factor predictivo más potente de ECV a los 10 años en ambos sexos. Las variables asociadas con ECV en los varones fueron el tratamiento de la hipertensión arterial (HR: 1,35; IC al 95%: 1,067−1,710), la diabetes (HR: 1,359; IC al 95%: 0,997−1,852) y el tabaquismo (HR: 1,207; IC al 95%: 0,945−1,541) y en las mujeres, el tabaquismo (HR: 1,881; IC al 95%: 1,356−2,609) y la diabetes (HR: 1,285; IC al 95%: 0,967−1,707). El colesterol-total no aumentó el riesgo de ECV, ni en varones ni en mujeres. Sin embargo, las concentraciones de colesterol total > 200 mg/dL se asociaron inversamente al riesgo de ECV a los 10 años, tanto en varones como en mujeres. Conclusiones. La ECV total a los 10 años aumenta significativamente en los varones españoles de edad avanzada con la edad, la diabetes y el tratamiento antihipertensivo y en las mujeres con la diabetes y el tabaquismo. Los niveles de c

Published
2021

36. The Prospective Studies of Atherosclerosis (Proof-ATHERO) Consortium : Design and Rationale

Author

Tschiderer, Lena, Seekircher, Lisa, Klingenschmid, Gerhard, Izzo, Raffaele, Baldassarre, Damiano, Iglseder, Bernhard, Calabresi, Laura, Liu, Jing, Price, JackieF., Bae, Jang-Ho, Brouwers, FrankP., de Groot, Eric, Schmidt, Caroline, Bergstroem, Goeran, Asci, Guelay, Gresele, Paolo, Okazaki, Shuhei, Kapellas, Kostas, Landecho, ManuelF., Sattar, Naveed, Agewall, Stefan, Zou, Zhi-Yong, Byrne, Christopher D., Nanayakkara, Prabath W. B., Papagianni, Aikaterini, Witham, Miles D., Bernal, Enrique, Ekart, Robert, van Agtmael, Michiel A., Neves, Mario F., Sato, Eiichi, Ezhov, Marat, Walters, Matthew, Olsen, Michael H., Stolic, Radojica, Zozulinska-Ziolkiewicz, DorotaA., Hanefeld, Markolf, Staub, Daniel, Nagai, Michiaki, Nieuwkerk, Pythia T., Huisman, Menno V., Kato, Akihiko, Honda, Hirokazu, Parraga, Grace, Magliano, Dianna, Gabriel, Rafael, Rundek, Tatjana, Espeland, Mark A., Kiechl, Stefan, Willeit, Johann, Lind, Lars, Empana, Jean Philippe, Lonn, Eva, Tuomainen, Tomi-Pekka, Catapano, Alberico, Chien, Kuo-Liong, Sander, Dirk, Kavousi, Maryam, Beulens, Joline W. J., Bots, Michiel L., Sweeting, Michael J., Lorenz, Matthias W., Willeit, Peter, Tschiderer, Lena, Seekircher, Lisa, Klingenschmid, Gerhard, Izzo, Raffaele, Baldassarre, Damiano, Iglseder, Bernhard, Calabresi, Laura, Liu, Jing, Price, JackieF., Bae, Jang-Ho, Brouwers, FrankP., de Groot, Eric, Schmidt, Caroline, Bergstroem, Goeran, Asci, Guelay, Gresele, Paolo, Okazaki, Shuhei, Kapellas, Kostas, Landecho, ManuelF., Sattar, Naveed, Agewall, Stefan, Zou, Zhi-Yong, Byrne, Christopher D., Nanayakkara, Prabath W. B., Papagianni, Aikaterini, Witham, Miles D., Bernal, Enrique, Ekart, Robert, van Agtmael, Michiel A., Neves, Mario F., Sato, Eiichi, Ezhov, Marat, Walters, Matthew, Olsen, Michael H., Stolic, Radojica, Zozulinska-Ziolkiewicz, DorotaA., Hanefeld, Markolf, Staub, Daniel, Nagai, Michiaki, Nieuwkerk, Pythia T., Huisman, Menno V., Kato, Akihiko, Honda, Hirokazu, Parraga, Grace, Magliano, Dianna, Gabriel, Rafael, Rundek, Tatjana, Espeland, Mark A., Kiechl, Stefan, Willeit, Johann, Lind, Lars, Empana, Jean Philippe, Lonn, Eva, Tuomainen, Tomi-Pekka, Catapano, Alberico, Chien, Kuo-Liong, Sander, Dirk, Kavousi, Maryam, Beulens, Joline W. J., Bots, Michiel L., Sweeting, Michael J., Lorenz, Matthias W., and Willeit, Peter

Abstract

Atherosclerosis - the pathophysiological mechanism shared by most cardiovascular diseases - can be directly or indirectly assessed by a variety of clinical tests including measurement of carotid intima-media thickness, carotid plaque, ankle-brachial index, pulse wave velocity, and coronary artery calcium. The Prospective Studies of Atherosclerosis (Proof-ATHERO) consortium (https://clinicalepi.i-med.ac.at/research/proof-athero/) collates de-identified individual-participant data of studies with information on atherosclerosis measures, risk factors for cardiovascular disease, and incidence of cardiovascular diseases. It currently comprises 74 studies that involve 106,846 participants from 25 countries and over 40 cities. In summary, 21 studies recruited participants from the general population (n = 67,784), 16 from high-risk populations (n = 22,677), and 37 as part of clinical trials (n = 16,385). Baseline years of contributing studies range from April 1980 to July 2014; the latest follow-up was until June 2019. Mean age at baseline was 59 years (standard deviation: 10) and 50% were female. Over a total of 830,619 person-years of follow-up, 17,270 incident cardiovascular events (including coronary heart disease and stroke) and 13,270 deaths were recorded, corresponding to cumulative incidences of 2.1% and 1.6% per annum, respectively. The consortium is coordinated by the Clinical Epidemiology Team at the Medical University of Innsbruck, Austria. Contributing studies undergo a detailed data cleaning and harmonisation procedure before being incorporated in the Proof-ATHERO central database. Statistical analyses are being conducted according to pre-defined analysis plans and use established methods for individual-participant data meta-analysis. Capitalising on its large sample size, the multi-institutional collaborative Proof-ATHERO consortium aims to better characterise, understand, and predict the development of atherosclerosis and its clinical consequences.

Published
2020
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37. The Prospective Studies of Atherosclerosis (Proof-ATHERO) Consortium: Design and Rationale

Author

Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epidemiologie, Tschiderer, Lena, Seekircher, Lisa, Klingenschmid, Gerhard, Izzo, Raffaele, Baldassarre, Damiano, Iglseder, Bernhard, Calabresi, Laura, Liu, Jing, Price, Jackie F., Bae, Jang Ho, Brouwers, Frank P., De Groot, Eric, Schmidt, Caroline, Bergström, Göran, Aşçi, Gülay, Gresele, Paolo, Okazaki, Shuhei, Kapellas, Kostas, Landecho, Manuel F., Sattar, Naveed, Agewall, Stefan, Zou, Zhi Yong, Byrne, Christopher D., Nanayakkara, Prabath W.B., Papagianni, Aikaterini, Witham, Miles D., Bernal, Enrique, Ekart, Robert, Van Agtmael, Michiel A., Neves, Mario F., Sato, Eiichi, Ezhov, Marat, Walters, Matthew, Olsen, Michael H., Stolić, Radojica, Zozulińska-Ziółkiewicz, Dorota A., Hanefeld, Markolf, Staub, Daniel, Nagai, Michiaki, Nieuwkerk, Pythia T., Huisman, Menno V., Kato, Akihiko, Honda, Hirokazu, Parraga, Grace, Magliano, Dianna, Gabriel, Rafael, Rundek, Tatjana, Espeland, Mark A., Beulens, Joline W.J., Bots, Michiel L., Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epidemiologie, Tschiderer, Lena, Seekircher, Lisa, Klingenschmid, Gerhard, Izzo, Raffaele, Baldassarre, Damiano, Iglseder, Bernhard, Calabresi, Laura, Liu, Jing, Price, Jackie F., Bae, Jang Ho, Brouwers, Frank P., De Groot, Eric, Schmidt, Caroline, Bergström, Göran, Aşçi, Gülay, Gresele, Paolo, Okazaki, Shuhei, Kapellas, Kostas, Landecho, Manuel F., Sattar, Naveed, Agewall, Stefan, Zou, Zhi Yong, Byrne, Christopher D., Nanayakkara, Prabath W.B., Papagianni, Aikaterini, Witham, Miles D., Bernal, Enrique, Ekart, Robert, Van Agtmael, Michiel A., Neves, Mario F., Sato, Eiichi, Ezhov, Marat, Walters, Matthew, Olsen, Michael H., Stolić, Radojica, Zozulińska-Ziółkiewicz, Dorota A., Hanefeld, Markolf, Staub, Daniel, Nagai, Michiaki, Nieuwkerk, Pythia T., Huisman, Menno V., Kato, Akihiko, Honda, Hirokazu, Parraga, Grace, Magliano, Dianna, Gabriel, Rafael, Rundek, Tatjana, Espeland, Mark A., Beulens, Joline W.J., and Bots, Michiel L.

Published
2020

46. Comparing different definitions of prediabetes with subsequent risk of diabetes: An individual participant data meta-analysis involving 76 513 individuals and 8208 cases of incident diabetes

Author

Lee, Crystal Man Ying, Colagiuri, Stephen, Woodward, Mark, Gregg, Edward W., Adams, Robert, Azizi, Fereidoun, Gabriel, Rafael, Gill, Tiffany K., Gonzalez, Clicerio, Hodge, Allison, Jacobs, David R., Joseph, Joshua J., Khalili, Davood, Magliano, Dianna J, Mehlig, Kirsten, Milne, Roger, Mishra, Gita, Mongraw-Chaffin, Morgana, Pasco, Julie A., Sakurai, Masaru, Schreiner, Pamela J., Selvin, Elizabeth, Shaw, Jonathan E., Wittert, Gary, Yatsuya, Hiroshi, Huxley, Rachel R., Lee, Crystal Man Ying, Colagiuri, Stephen, Woodward, Mark, Gregg, Edward W., Adams, Robert, Azizi, Fereidoun, Gabriel, Rafael, Gill, Tiffany K., Gonzalez, Clicerio, Hodge, Allison, Jacobs, David R., Joseph, Joshua J., Khalili, Davood, Magliano, Dianna J, Mehlig, Kirsten, Milne, Roger, Mishra, Gita, Mongraw-Chaffin, Morgana, Pasco, Julie A., Sakurai, Masaru, Schreiner, Pamela J., Selvin, Elizabeth, Shaw, Jonathan E., Wittert, Gary, Yatsuya, Hiroshi, and Huxley, Rachel R.

Published
2019

49. Was the Historic Contribution of Spain to the Mexican Gene Pool Partially Responsible for the Higher Prevalence of Type 2 Diabetes in Mexican-Origin Populations? (Epidemiology/Health Services/Psychosocial Research)

Author

Lorenzo, Carlos, Serrano-Rios, Manel, Martinez-Larrad, Maria T., Gabriel, Rafael, Williams, Ken, Gonzalez-Villalpando, Clicerio, Stern, Michel P., Hazuda, Helen P., and Haffner, Steven M.

Subjects
Spain -- Health aspects, Mexico -- Health aspects, Diabetes -- Research, Mexicans -- Genetic aspects -- Health aspects, Spaniards -- Genetic aspects -- Health aspects, Type 2 diabetes -- Risk factors -- Genetic aspects, Health, Genetic aspects, Risk factors, Health aspects
Abstract

Carlos Lorenzo (1) Manel Serrano-Rios (2) Maria T. Martinez-Larrad (2) Rafael Gabriel (3) Ken Williams (1) Clicerio Gonzalez-Villalpando (+) Michel P. Stern (1) Helen P. Hazuda (1) Steven M. Haffner [...]

Published
2001

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