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1. Trends in use of neoadjuvant systemic therapy in patients with clinically node-positive breast cancer in Europe: prospective TAXIS study (OPBC-03, SAKK 23/16, IBCSG 57-18, ABCSG-53, GBG 101)

Author

Tausch, Christoph, Däster, Kavitha, Hayoz, Stefanie, Matrai, Zoltan, Fitzal, Florian, Henke, Guido, Zwahlen, Daniel R., Gruber, Günther, Zimmermann, Frank, Andreozzi, Mariacarla, Goldschmidt, Maite, Schulz, Alexandra, Maggi, Nadia, Saccilotto, Ramon, Heidinger, Martin, Mueller, Andreas, Tampaki, Ekaterini Christina, Bjelic-Radisic, Vesna, Sávolt, Ákos, Smanykó, Viktor, Hagen, Daniela, Müller, Dieter J., Gnant, Michael, Loibl, Sibylle, Markellou, Pagona, Bekes, Inga, Egle, Daniel, Ruhstaller, Thomas, Muenst, Simone, Kuemmel, Sherko, Vrieling, Conny, Satler, Rok, Becciolini, Charles, Bucher, Susanne, Kurzeder, Christian, Simonson, Colin, Fehr, Peter M., Gabriel, Natalie, Maráz, Robert, Sarlos, Dimitri, Dedes, Konstantin J., Leo, Cornelia, Berclaz, Gilles, Fansa, Hisham, Hager, Christopher, Reisenberger, Klaus, Singer, Christian F., Montagna, Giacomo, Reitsamer, Roland, Winkler, Jelena, Lam, Giang Thanh, Fehr, Mathias K., Naydina, Tatiana, Kohlik, Magdalena, Clerc, Karine, Ostapenko, Valerijus, Lelièvre, Loïc, Heil, Jörg, Knauer, Michael, and Weber, Walter Paul

Published
2023
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2. Tailored axillary surgery in patients with clinically node-positive breast cancer: Pre-planned feasibility substudy of TAXIS (OPBC-03, SAKK 23/16, IBCSG 57-18, ABCSG-53, GBG 101)

Author

Weber, Walter P., Matrai, Zoltan, Hayoz, Stefanie, Tausch, Christoph, Henke, Guido, Zwahlen, Daniel R., Gruber, Günther, Zimmermann, Frank, Seiler, Stefanie, Maddox, Charlotte, Ruhstaller, Thomas, Muenst, Simone, Ackerknecht, Markus, Kuemmel, Sherko, Bjelic-Radisic, Vesna, Kurzeder, Christian, Újhelyi, Mihály, Vrieling, Conny, Satler, Rok, Meyer, Inna, Becciolini, Charles, Bucher, Susanne, Simonson, Colin, Fehr, Peter M., Gabriel, Natalie, Maráz, Robert, Sarlos, Dimitri, Dedes, Konstantin J., Leo, Cornelia, Berclaz, Gilles, Dubsky, Peter, Exner, Ruth, Fansa, Hisham, Hager, Christopher, Reisenberger, Klaus, Singer, Christian F., Reitsamer, Roland, Reinisch, Mattea, Winkler, Jelena, Lam, Giang Thanh, Fehr, Mathias K., Naydina, Tatiana, Kohlik, Magdalena, Clerc, Karine, Ostapenko, Valerijus, Fitzal, Florian, Nussbaumer, Rahel, Maggi, Nadia, Schulz, Alexandra, Markellou, Pagona, Lelièvre, Loïc, Egle, Daniel, Heil, Jörg, and Knauer, Michael

Published
2021
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5. Impact of a Surgical Sealing Patch on Lymphatic Drainage After Axillary Dissection for Breast Cancer: The SAKK 23/13 Multicenter Randomized Phase III Trial

Author

Weber, Walter Paul, Tausch, Christoph, Hayoz, Stefanie, Fehr, Mathias Konrad, Ribi, Karin, Hawle, Hanne, Lupatsch, Judith Eva, Matter-Walstra, Klazien, Chiesa, Federica, Dedes, Konstantin Johannes, Berclaz, Gilles, Lelièvre, Loic, Hess, Thomas, Güth, Uwe, Pioch, Verena, Sarlos, Dimitri, Leo, Cornelia, Canonica, Claudia, Gabriel, Natalie, Zeindler, Jasmin, Cassoly, Estelle, Andrieu, Christiane, Soysal, Savas Deniz, Ruhstaller, Thomas, Fehr, Peter Martin, Knauer, Michael, and for the Swiss Group for Clinical Cancer Research (SAKK)

Published
2018
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6. Relation between candidiasis and linear gingival erythema in HIV-positive patients.

Author

Venâncio, Wellington Bruno, Izumi, Camila Akemi, Riera Gabriel, Natalie Temporão, Januário, Diogo Berwanger, de Oliveira Sudol, Daiane, Lima Soares, Antônio Adilson, and Silva Soares, Geisla Mary

Subjects
HEALTH behavior, HIV-positive persons, CANDIDIASIS, PERSONALLY identifiable information, ERYTHEMA
Abstract

Objective: To assess the prevalence of candidiasis associated with Linear Gingival Erythema (LGE) in patients with HIV. Material and methods: Patients with HIV who sought care were identified and those with linear gingival erythema were included in the study. Initially, a questionnaire divided into two parts was applied, the first session consisting of personal and sociodemographic data and the second session containing questions related to health habits. Then, erythema samples were collected with a collector brush and cultivated in petri dishes containing CHROMagar for 3 days under aerobic conditions at room temperature. Plaque evaluation and colony counts were performed. Results: From a total of 46 patients, thirteen were included in the study. Among the samples, eleven were diagnosed with C. albicans and five were diagnosed with other species of Candida sp. Conclusion: A high prevalence of Candida sp. was observed on patients with lesions of linear gingival erythema and diagnosed with HIV. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Abstract PD15-11: PD15-11 Axillary dissection to determine nodal burden to inform systemic therapy recommendations in patients with clinically node-positive breast cancer: Pre-planned substudy of TAXIS (OPBC-03, SAKK 23/16, IBCSG 57-18, ABCSG-53, GBG 101)

Author

Weber, Walter P., primary, Matrai, Zoltan, additional, Hayoz, Stefanie, additional, Tausch, Christoph, additional, Henke, Guido, additional, Zwahlen, Daniel R., additional, Gruber, Günther, additional, Zimmermann, Frank, additional, Ruhstaller, Thomas, additional, Muenst, Simone, additional, Ackerknecht, Markus, additional, Küemmel, Sherko, additional, Bjelic-Radisic, Vesna, additional, Smanykó, Viktor, additional, Vrieling, Conny, additional, Satler, Rok, additional, Meyer, Inna, additional, Becciolini, Charles, additional, Bucher, Susanne, additional, Simonson, Colin, additional, Fehr, Peter M., additional, Gabriel, Natalie, additional, Maráz, Robert, additional, Sarlos, Dimitri, additional, Dedes, Konstantin J., additional, Leo, Cornelia, additional, Berclaz, Gilles, additional, Fansa, Hisham, additional, Hager, Christopher, additional, Reisenberger, Klaus, additional, Sávolt, Ákos, additional, Singer, Christian F., additional, Reitsamer, Roland, additional, Winkler, Jelena, additional, Lam, Giang Thanh Lam, additional, Fehr, Mathias K., additional, Naydina, Tatiana, additional, Kohlik, Magdalena, additional, Clerc, Karine, additional, Ostapenko, Valerijus, additional, Fitzal, Florian, additional, Heidinger, Martin, additional, Maggi, Nadia, additional, Schulz, Alexandra, additional, Markellou, Pagona, additional, Lelièvre, Loïc, additional, Egle, Daniel, additional, Heil, Jörg, additional, Knauer, Michael, additional, and Kurzeder, Christian, additional

Published
2023
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8. Association of Axillary Dissection With Systemic Therapy in Patients With Clinically Node-Positive Breast Cancer

Author

Weber, Walter P., Matrai, Zoltan, Hayoz, Stefanie, Tausch, Christoph, Henke, Guido, Zimmermann, Frank, Montagna, Giacomo, Fitzal, Florian, Gnant, Michael, Ruhstaller, Thomas, Muenst, Simone, Mueller, Andreas, Lelièvre, Loïc, Heil, Jörg, Knauer, Michael, Egle, Daniel, Sávolt, Ákos, Heidinger, Martin, Kurzeder, Christian, Zwahlen, Daniel R., Gruber, Günther, Ackerknecht, Markus, Kuemmel, Sherko, Bjelic-Radisic, Vesna, Smanykó, Viktor, Vrieling, Conny, Satler, Rok, Hagen, Daniela, Becciolini, Charles, Bucher, Susanne, Simonson, Colin, Fehr, Peter M., Gabriel, Natalie, Maráz, Robert, Sarlos, Dimitri, Dedes, Konstantin J., Leo, Cornelia, Berclaz, Gilles, Fansa, Hisham, Hager, Christopher, Reisenberger, Klaus, Singer, Christian F., Loibl, Sibylle, Winkler, Jelena, Lam, Giang Thanh, Fehr, Mathias K., Kohlik, Magdalena, Clerc, Karine, Ostapenko, Valerijus, Maggi, Nadia, Schulz, Alexandra, Andreozzi, Mariacarla, Goldschmidt, Maite, Saccilotto, Ramon, and Markellou, Pagona

Abstract

IMPORTANCE: The role of axillary lymph node dissection (ALND) to determine nodal burden to inform systemic therapy recommendations in patients with clinically node (cN)–positive breast cancer (BC) is currently unknown. OBJECTIVE: To address the association of ALND with systemic therapy in cN-positive BC in the upfront surgery setting and after neoadjuvant chemotherapy (NACT). DESIGN, SETTING, AND PARTICIPANTS: This was a prospective, observational, cohort study conducted from August 2018 to June 2022. This was a preplanned study within the phase 3 randomized clinical OPBC-03/TAXIS trial. Included were patients with confirmed cN-positive BC from 44 private, public, and academic breast centers in 6 European countries. After NACT, residual nodal disease was mandatory, and a minimum follow-up of 2 months was required. EXPOSURES: All patients underwent tailored axillary surgery (TAS) followed by ALND or axillary radiotherapy (ART) according to TAXIS randomization. TAS removed suspicious palpable and sentinel nodes, whereas imaging-guidance was optional. Systemic therapy recommendations were at the discretion of the local investigators. RESULTS: A total of 500 patients (median [IQR] age, 57 [48-69] years; 487 female [97.4%]) were included in the study. In the upfront surgery setting, 296 of 335 patients (88.4%) had hormone receptor (HR)–positive and Erb-B2 receptor tyrosine kinase 2 (ERBB2; formerly HER2 or HER2/neu)–negative disease: 145 (49.0%) underwent ART, and 151 (51.0%) underwent ALND. The median (IQR) number of removed positive lymph nodes without ALND was 3 (1-4) nodes compared with 4 (2-9) nodes with ALND. There was no association of ALND with the proportion of patients undergoing adjuvant chemotherapy (81 of 145 [55.9%] vs 91 of 151 [60.3%]; adjusted odds ratio [aOR], 0.72; 95% CI, 0.19-2.67) and type of systemic therapy. Of 151 patients with NACT, 74 (51.0%) underwent ART, and 77 (49.0%) underwent ALND. The ratio of removed to positive nodes was a median (IQR) of 4 (3-7) nodes to 2 (1-3) nodes and 15 (12-19) nodes to 2 (1-5) nodes in the ART and ALND groups, respectively. There was no observed association of ALND with the proportion of patients undergoing postneoadjuvant systemic therapy (57 of 74 [77.0%] vs 55 of 77 [71.4%]; aOR, 0.86; 95% CI, 0.43-1.70), type of postneoadjuvant chemotherapy (eg, capecitabine: 10 of 74 [13.5%] vs 10 of 77 [13.0%]; trastuzumab emtansine–DM1: 9 of 74 [12.2%] vs 11 of 77 [14.3%]), or endocrine therapy (eg, aromatase inhibitors: 41 of 74 [55.4%] vs 36 of 77 [46.8%]; tamoxifen: 8 of 74 [10.8%] vs 6 of 77 [7.8%]). CONCLUSION: Results of this cohort study suggest that patients without ALND were significantly understaged. However, ALND did not inform systemic therapy recommendations.

Published
2023
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9. Tailored axillary surgery in patients with clinically node-positive breast cancer: Pre-planned feasibility substudy of TAXIS (OPBC-03, SAKK 23/16, IBCSG 57-18, ABCSG-53, GBG 101)

Author

Weber, Walter P, Matrai, Zoltan, Hayoz, Stefanie, Tausch, Christoph, Henke, Guido, Zwahlen, Daniel R, Gruber, Günther, Zimmermann, Frank, Seiler, Stefanie, Maddox, Charlotte, Ruhstaller, Thomas, Muenst, Simone, Ackerknecht, Markus, Kuemmel, Sherko, Bjelic-Radisic, Vesna, Kurzeder, Christian, Újhelyi, Mihály, Vrieling, Conny, Satler, Rok, Meyer, Inna, Becciolini, Charles, Bucher, Susanne, Simonson, Colin, Fehr, Peter M, Gabriel, Natalie, Maráz, Robert, Sarlos, Dimitri, Dedes, Konstantin J, Leo, Cornelia, Berclaz, Gilles, et al, University of Zurich, and Weber, Walter P

Subjects
610 Medicine & health, 2730 Oncology, 1306 Cancer Research, Surgery, General Medicine, 10174 Clinic for Gynecology, 2746 Surgery
Published
2021

11. ENGOT-ov54/Swiss-GO-2/MATAO including LOGOS (Low-Grade Ovarian cancer Sub-study): MAintenance Therapy with Aromatase inhibitor in epithelial Ovarian cancer—A randomized, double-blinded, placebo-controlled, multicenter phase III Trial.

Author

Heinzelmann-Schwarz, Viola A., primary, Kurzeder, Christian, additional, Schmid, Seraina, additional, Gabriel, Natalie, additional, Mueller, Andreas, additional, Fehr, Mathias Konrad, additional, Marth, Christian, additional, Du Bois, Andreas, additional, and Klar, Maximillian, additional

Published
2021
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17. LETTERS.

Author

Gabriel, Natalie and Lombardo, P.

Published
2018

18. Hiding in a friendship.

Author

Azuaga-Gabriel, Natalie

Subjects
HIDING in a Friendship (Poem), AZUAGA-Gabriel, Natalie
Abstract

The article presents the poem "Hiding in a friendship." First Line: "I hate what I've become," said she: Last Line: "We'll see," said he.

Published
2007

19. [Current adjuvant endocrine treatment of breast cancer].

Author

Dedes KJ, Gabriel N, and Fink D

Subjects
Chemotherapy, Adjuvant methods, Chemotherapy, Adjuvant trends, Female, Humans, Antineoplastic Agents, Hormonal administration & dosage, Aromatase Inhibitors administration & dosage, Breast Neoplasms drug therapy, Tamoxifen administration & dosage
Abstract

Hormone-receptor-positive cancer is the most common tumor subtype in women with breast cancer. Endocrine treatment in this subgroup is essential for premenopausal as well as postmenopausal patients. Tamoxifen substantially improves disease-free survival and overall survival in combination with chemotherapy or alone in adjuvant therapy. In recent years, a number of large-scale, randomized trials have evaluated the role of the aromatase inhibitors (AI) in postmenopausal women with hormone-receptor-positive breast cancer. These studies tested one of three approaches: (1) an upfront AI, (2) a sequential approach after 2-3 years of tamoxifen and (3) an extended endocrine therapy beyond 5 years. The positive results of these studies have challenged the previous standard of a 5-year course of tamoxifen alone. While the AI have become a standard component of treatment for most postmenopausal women, many questions still remain regarding the optimal endocrine treatment., (Copyright 2008 S. Karger AG, Basel.)

Published
2008
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