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1. Features of cryptococcosis among 652 HIV-seronegative individuals in France: a cross-sectional observational study (2005-2020)

Author

Brieu, N., Durand, C., Bertei, D., Bouchara, J.P., Pihet, M., Bland, S., Bru, J.P., Pulik, M., Le Turdu, F., Lefrand C, H., Ferrand, M., Larrouy, M., Millon, L., Delhaes, L., Imbert, S., Accoceberry, I., Bachelier, M.N., Nevez, G., Quinio, D., Le Coustumier, A., Carmagnol, F., Rivière, B., Boex, P., Podac, B., Moniot, M., Nourrisson, C., Augereau, O., Emond, J.P., Belkacem-Belkaki, G., Bacri, J.L., Berthelot, G., Dalle, F., Vallee, E., Bizet, J., Noussair, L., Herrmann, J.L., Maubon, D., Brocard, C., Guiffault, P., Layet, A., Morel, A., Angoulvant, A., Penn, P., Gigandon, A., Sendid, B., Cornu, M., Darde, M.L., Jaccard, A., Bouteille, B., Azjenberg, D., Prades, N., Bienvenu, A.L., Benoit-Cattin, T., Fiacre, A., Levy, S., Pitsch, A., Kiefer, M.H., Debourgogne, A., Moquet, O., Colot, J., Courtellemont, L., Poisson, D., Laurens, V., Kauffmann-Lacroix, C., Martres, P., Gargala, G., Godineau, N., Picot, S., Chassagne, C., Djibo, N., Devallière, R., Sabou, M., Camin-Ravenne, A.M., Bissuel, F., Janvier, F., Aubert, X., Chadapaud, S., Delbeck, X., Lafeuillade, A., Raoult, X., Baclet, V., Coignard, C., Mouton, Y., Ravaux, I., Eloy, C., Fur, A., Rezzouk, L., Mazards, E., Eloy, O., Chachaty, E., Mihaila, L., Dellion, S., Patey, O., Thouvenot, A., Limousin, L., Paugam, A., Desplaces, N., Raguin, G., Sitterlé, E., Blaize, M., Gits-Muselli, M., Hennequin, C., Poirot, J.L., Bretagne, S., Lacroix, Claire, Hamane, Samia, Paccoud, Olivier, Desnos-Ollivier, Marie, Persat, Florence, Demar, Magalie, Boukris-Sitbon, Karine, Bellanger, Anne-Pauline, Bonhomme, Julie, Bonnal, Christine, Botterel, Françoise, Bougnoux, Marie-Elisabeth, Brun, Sophie, Cassaing, Sophie, Cateau, Estelle, Chouaki, Taieb, Cornet, Muriel, Dannaoui, Eric, Desbois-Nogard, Nicole, Durieux, Marie-Fleur, Favennec, Loïc, Fekkar, Arnaud, Gabriel, Frederic, Gangneux, Jean-Pierre, Guitard, Juliette, Hasseine, Lilia, Huguenin, Antoine, Le Gal, Solène, Letscher-Bru, Valérie, Mahinc, Caroline, Morio, Florent, Nicolas, Muriel, Poirier, Philippe, Ranque, Stéphane, Roosen, Gabrielle, Rouges, Célia, Roux, Anne-Laure, Sasso, Milène, Alanio, Alexandre, Lortholary, Olivier, and Lanternier, Fanny

Published
2024
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2. Characteristics and Prognosis Factors of Pneumocystis jirovecii Pneumonia According to Underlying Disease: A Retrospective Multicenter Study

Author

Raffi, Francois, Boutoille, David, Biron, Charlotte, Lefebvre, Maeva, Gaborit, Benjamin Jean, Le Turnier, Paul, Deschanvres, Colin, Lecomte, Raphael, Chauveau, Marie, Lécuyer, Romain, Asquier-Khati, Antoine, Le Pape, Patrice, Morio, Florent, Lavergne, Rose-Anne, Jeddi, Fakhri, Corvec, Stéphane, Bemer, Pascale, Caillon, Jocelyne, Guillouzouic, Aurélie, Leroy, Anne-Gaëlle, Lakhal, Karim, Cinotti, Raphaël, Roquilly, Antoine, Emmanuel Canet, Jean Reignier, Blanc, François Xavier, Bretonniere, Cédric, Morin, Paul, Camou, Fabrice, Issa, Nahéma, Guisset, Olivier, Mourissoux, Gaelle, Accoceberry, Isabelle, Gabriel, Frederic, Coron, Noémie, Delhaes, Laurence, Imbert, Sébastien, Lefranc, Maxime, Lussac-Sorton, Florian, Rougeron, Amandine, Gousseff, Marie, Crabol, Yoann, Corvaisier, Grégory, Lautredoux, Florent, Cady, Anne, Auger, Myriam, Pouedras, Pascal, Lavergne, Rose-anne, Canet, Emmanuel, Raffi, François, Néel, Antoine, Tessoulin, Benoît, and Gaborit, Benjamin

Published
2024
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3. Should We Reconsider PneumocystisPneumonia Presentation and Treatment According to Its Underlying Disease?

Author

Gaborit, Benjamin, Lécuyer, Romain, Issa, Nahéma, Camou, Fabrice, Lavergne, Rose-anne, Gabriel, Frederic, Morio, Florent, Canet, Emmanuel, Raffi, François, Boutoille, David, Cady, Anne, Gousseff, Marie, Crabol, Yoann, Néel, Antoine, Tessoulin, Benoît, Raffi, Francois, Boutoille, David, Biron, Charlotte, Lefebvre, Maeva, Gaborit, Benjamin Jean, Le Turnier, Paul, Deschanvres, Colin, Lecomte, Raphael, Chauveau, Marie, Lécuyer, Romain, Asquier-Khati, Antoine, Pineau, Valentin, Prime, Marie, Delaunay, Clarisse, Essid, Hakim, Le Pape, Patrice, Morio, Florent, Lavergne, Rose-Anne, Jeddi, Fakhri, Corvec, Stéphane, Bemer, Pascale, Caillon, Jocelyne, Guillouzouic, Aurélie, Leroy, Anne-Gaëlle, Lakhal, Karim, Cinotti, Raphaël, Roquilly, Antoine, Jean Reignier, Mickael Vourc’h;, Canet, Emmanuel, Blanc, François Xavier, Bretonniere, Cédric, Morin, Jean, Le Blanc, Camille, Alami, Hakim, Camou, Fabrice, Issa, Nahéma, Guisset, Olivier, Mourissoux, Gaelle, Accoceberry, Isabelle, Gabriel, Frederic, Coron, Noémie, Delhaes, Laurence, Imbert, Sébastien, Lefranc, Maxime, Lussac-Sorton, Florian, Rougeron, Amandine, Gousseff, Marie, Crabol, Yoann, Corvaisier, Grégory, Lautredoux, Florent, Anne Cady, Romain Lécuyerand, Auger, Myriam, and Pouedras, Pascal

Published
2024
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4. Should we reconsider Pneumocystis pneumonia presentation and treatment according to its underlying disease? An unsupervised cluster analysis of a retrospective multicentre study

Author

Gaborit, Benjamin, primary, Lécuyer, Romain, additional, Issa, Nahéma, additional, Camou, Fabrice, additional, Lavergne, Rose-anne, additional, Gabriel, Frederic, additional, Morio, Florent, additional, Canet, Emmanuel, additional, Raffi, François, additional, Boutoille, David, additional, Cady, Anne, additional, Gousseff, Marie, additional, Crabol, Yoann, additional, Néel, Antoine, additional, Tessoulin, Benoît, additional, Raffi, Francois, additional, Biron, Charlotte, additional, Lefebvre, Maeva, additional, Le Turnier, Paul, additional, Deschanvres, Colin, additional, Lecomte, Raphael, additional, Chauveau, Marie, additional, Asquier-Khati, Antoine, additional, Pineau, Valentin, additional, Prime, Marie, additional, Delaunay, Clarisse, additional, Essid, Hakim, additional, Le Pape, Patrice, additional, Jeddi, Fakhri, additional, Corvec, Stéphane, additional, Bemer, Pascale, additional, Caillon, Jocelyne, additional, Guillouzouic, Aurélie, additional, Leroy, Anne-Gaëlle, additional, Lakhal, Karim, additional, Cinotti, Raphaël, additional, Roquilly, Antoine, additional, Vourc’h, Mickael, additional, Reignier, Jean, additional, Blanc, François Xavier, additional, Bretonniere, Cédric, additional, Morin, Jean, additional, Le Blanc, Camille, additional, Alami, Hakim, additional, Guisset, Olivier, additional, Mourissoux, Gaelle, additional, Accoceberry, Isabelle, additional, Coron, Noémie, additional, Delhaes, Laurence, additional, Imbert, Sébastien, additional, Lefranc, Maxime, additional, Lussac-Sorton, Florian, additional, Rougeron, Amandine, additional, Corvaisier, Grégory, additional, Lautredoux, Florent, additional, Auger, Myriam, additional, and Pouedras, Pascal, additional

Published
2024
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5. Mechanisms of systemic low-grade inflammation in HIV patients on long-term suppressive antiretroviral therapy: the inflammasome hypothesis

Author

Guerville, Florent, Vialemaringe, Marine, Cognet, Celine, Duffau, Pierre, Lazaro, Estibaliz, Cazanave, Charles, Bonnet, Fabrice, Leleux, Olivier, Rossignol, Rodrigue, Pinson, Benoît, Tumiotto, Camille, Gabriel, Frederic, Appay, Victor, Déchanet-Merville, Julie, Wittkop, Linda, Faustin, Benjamin, and Pellegrin, Isabelle

Published
2023
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6. Features of cryptococcosis among 652 HIV-seronegative individuals in France: a cross-sectional observational study (2005-2020)

Author

Paccoud, Olivier, primary, Desnos-Ollivier, Marie, additional, Persat, Florence, additional, Demar, Magalie, additional, Boukris-Sitbon, Karine, additional, Bellanger, Anne-Pauline, additional, Bonhomme, Julie, additional, Bonnal, Christine, additional, Botterel, Françoise, additional, Bougnoux, Marie-Elisabeth, additional, Brun, Sophie, additional, Cassaing, Sophie, additional, Cateau, Estelle, additional, Chouaki, Taieb, additional, Cornet, Muriel, additional, Dannaoui, Eric, additional, Desbois-Nogard, Nicole, additional, Durieux, Marie-Fleur, additional, Favennec, Loïc, additional, Fekkar, Arnaud, additional, Gabriel, Frederic, additional, Gangneux, Jean-Pierre, additional, Guitard, Juliette, additional, Hasseine, Lilia, additional, Huguenin, Antoine, additional, Le Gal, Solène, additional, Letscher-Bru, Valérie, additional, Mahinc, Caroline, additional, Morio, Florent, additional, Nicolas, Muriel, additional, Poirier, Philippe, additional, Ranque, Stéphane, additional, Roosen, Gabrielle, additional, Rouges, Célia, additional, Roux, Anne-Laure, additional, Sasso, Milène, additional, Alanio, Alexandre, additional, Lortholary, Olivier, additional, Lanternier, Fanny, additional, Brieu, N., additional, Durand, C., additional, Bertei, D., additional, Bouchara, J.P., additional, Pihet, M., additional, Bland, S., additional, Bru (Annecy), J.P., additional, Pulik, M., additional, Le Turdu, F., additional, Lefrand, C, H., additional, Ferrand, M., additional, Larrouy, M., additional, Millon, L., additional, Delhaes, L., additional, Imbert, S., additional, Accoceberry, I., additional, Bachelier, M.N., additional, Nevez, G., additional, Quinio, D., additional, Le Coustumier, A., additional, Carmagnol, F., additional, Rivière, B., additional, Boex, P., additional, Podac, B., additional, Moniot, M., additional, Nourrisson, C., additional, Augereau, O., additional, Emond, J.P., additional, Belkacem-Belkaki, G., additional, Bacri, J.L., additional, Berthelot, G., additional, Dalle, F., additional, Vallee, E., additional, Bizet, J., additional, Noussair, L., additional, Herrmann, J.L., additional, Maubon, D., additional, Brocard, C., additional, Guiffault, P., additional, Layet, A., additional, Morel, A., additional, Angoulvant, A., additional, Penn, P., additional, Gigandon, A., additional, Sendid, B., additional, Cornu, M., additional, Darde, M.L., additional, Jaccard, A., additional, Bouteille, B., additional, Azjenberg, D., additional, Prades, N., additional, Bienvenu, A.L., additional, Benoit-Cattin, T., additional, Fiacre, A., additional, Levy, S., additional, Pitsch, A., additional, Kiefer, M.H., additional, Debourgogne, A., additional, Moquet, O., additional, Colot, J., additional, Courtellemont, L., additional, Poisson, D., additional, Laurens, V., additional, Kauffmann-Lacroix, C., additional, Martres, P., additional, Gargala, G., additional, Godineau, N., additional, Picot, S., additional, Chassagne, C., additional, Djibo, N., additional, Devallière, R., additional, Sabou, M., additional, Camin-Ravenne, A.M., additional, Bissuel, F., additional, Janvier, F., additional, Aubert, X., additional, Chadapaud, S., additional, Delbeck, X., additional, Lafeuillade, A., additional, Raoult, X., additional, Baclet, V., additional, Coignard, C., additional, Mouton, Y., additional, Ravaux, I., additional, Eloy, C., additional, Fur, A., additional, Rezzouk, L., additional, Mazards, E., additional, Eloy, O., additional, Chachaty, E., additional, Mihaila, L., additional, Dellion, S., additional, Patey, O., additional, Thouvenot, A., additional, Limousin, L., additional, Paugam, A., additional, Desplaces, N., additional, Raguin, G., additional, Sitterlé, E., additional, Blaize, M., additional, Gits-Muselli, M., additional, Hennequin, C., additional, Poirot, J.L., additional, Bretagne, S., additional, Lacroix, Claire, additional, and Hamane, Samia, additional

Published
2024
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7. Gentiles in Court. From Superficial Idolatry to Implicit Faith: The Unveiling of Grace and Salvation in the Works of Paschal Rapine de Sainte-Marie (1655–1659)

Author

Gabriel, Frédéric, Giglioni, Guido, Associate Editor, Dibon, Paul, Founding Editor, Popkin, Richard H., Founding Editor, Hutton, Sarah, Editor-in-Chief, Laursen, J.C., Associate Editor, Vermeir, K., Editorial Board Member, Neto, J.R. Maia, Editorial Board Member, Allen, M.J.B., Editorial Board Member, Armogathe, J.-R., Editorial Board Member, Clucas, S., Editorial Board Member, Harrison, P., Editorial Board Member, Henry, J., Editorial Board Member, Mulsow, M., Editorial Board Member, Paganini, G., Editorial Board Member, Popkin, J., Editorial Board Member, Rogers, G.A.J., Editorial Board Member, Sebastian, J.F., Editorial Board Member, Thomson, A., Editorial Board Member, Verbeek, Th., Editorial Board Member, Robertson, J., Editorial Board Member, and Frigo, Alberto, editor

Published
2020
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8. Characteristics and Prognosis Factors of Pneumocystis jirovecii Pneumonia According to Underlying Disease: A Retrospective Multicenter Study.

Author

Lécuyer, Romain, Issa, Nahéma, Camou, Fabrice, Lavergne, Rose-anne, Gabriel, Frederic, Morio, Florent, Canet, Emmanuel, Raffi, François, Boutoille, David, Cady, Anne, Gousseff, Marie, Crabol, Yoann, Néel, Antoine, Tessoulin, Benoît, and Gaborit, Benjamin

Subjects
PNEUMOCYSTIS pneumonia, PNEUMOCYSTIS jiroveci, PROGNOSIS, SYMPTOMS, RETROSPECTIVE studies
Abstract

Pneumocystis jirovecii pneumonia (PcP) remains associated with high rates of mortality, and the impact of immunocompromising underlying disease on the clinical presentation, severity, and mortality of PcP has not been adequately evaluated. Does the underlying disease and immunosuppression causing PcP impact the outcome and clinical presentation of the disease? In this multicenter retrospective observational study, conducted from January 2011 to December 2021, all consecutive patients admitted with a proven or probable diagnosis of PcP according to the European Organisation for Research and Treatment of Cancer consensus definitions were included to assess the epidemiology and impact of underlying immunosuppressive diseases on overall and 90-day mortality. Overall, 481 patients were included in the study; 180 (37.4%) were defined as proven PcP and 301 (62.6%) were defined as probable PcP. Patients with immune-mediated inflammatory diseases (IMIDs) or solid tumors had a statistically poorer prognosis than other patients with PcP at day 90. In multivariate analysis, among the HIV-negative population, solid tumor underlying disease (OR, 5.47; 95% CI, 2.16-14.1; P <.001), IMIDs (OR, 2.19; 95% CI, 1.05-4.60; P =.037), long-term corticosteroid exposure (OR, 2.07; 95% CI, 1.03-4.31; P =.045), cysts in sputum/BAL smears (OR, 1.92; 95% CI, 1.02-3.62; P =.043), and SOFA score at admission (OR, 1.58; 95% CI, 1.39-1.82; P <.001) were independently associated with 90-day mortality. Prior corticotherapy was the only immunosuppressant associated with 90-day mortality (OR, 1.67; 95% CI, 1.03-2.71; P =.035), especially for a prednisone daily dose ≥ 10 mg (OR, 1.80; 95% CI, 1.14-2.85; P =.010). Among patients who were HIV-negative, long-term corticosteroid prior to PcP diagnosis was independently associated with increased 90-day mortality, specifically in patients with IMIDs. These results highlight both the needs for PcP prophylaxis in patients with IMIDs and to early consider PcP curative treatment in severe pneumonia among patients with IMIDs. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2024
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10. Should We Reconsider Pneumocystis Pneumonia Presentation and Treatment According to Its Underlying Disease?: An Unsupervised Cluster Analysis of a Retrospective Multicenter Study

Author

Raffi, Francois, Boutoille, David, Biron, Charlotte, Lefebvre, Maeva, Gaborit, Benjamin Jean, Le Turnier, Paul, Deschanvres, Colin, Lecomte, Raphael, Chauveau, Marie, Lécuyer, Romain, Asquier-Khati, Antoine, Pineau, Valentin, Prime, Marie, Delaunay, Clarisse, Essid, Hakim, Le Pape, Patrice, Morio, Florent, Lavergne, Rose-Anne, Jeddi, Fakhri, Corvec, Stéphane, Bemer, Pascale, Caillon, Jocelyne, Guillouzouic, Aurélie, Leroy, Anne-Gaëlle, Lakhal, Karim, Cinotti, Raphaël, Roquilly, Antoine, Jean Reignier, Mickael Vourc’h, Canet, Emmanuel, Blanc, François Xavier, Bretonniere, Cédric, Morin, Jean, Le Blanc, Camille, Alami, Hakim, Camou, Fabrice, Issa, Nahéma, Guisset, Olivier, Mourissoux, Gaelle, Accoceberry, Isabelle, Gabriel, Frederic, Coron, Noémie, Delhaes, Laurence, Imbert, Sébastien, Lefranc, Maxime, Lussac-Sorton, Florian, Rougeron, Amandine, Gousseff, Marie, Crabol, Yoann, Corvaisier, Grégory, Lautredoux, Florent, Anne Cady, Romain Lécuyerand, Auger, Myriam, Pouedras, Pascal, Gaborit, Benjamin, Lavergne, Rose-anne, Raffi, François, Cady, Anne, Néel, Antoine, and Tessoulin, Benoît

Published
2024
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11. Cryptococcus neoformans Infections Differ Among Human Immunodeficiency Virus (HIV)–Seropositive and HIV-Seronegative Individuals: Results From a Nationwide Surveillance Program in France.

Author

Paccoud, Olivier, Desnos-Ollivier, Marie, Cassaing, Sophie, Boukris-Sitbon, Karine, Alanio, Alexandre, Bellanger, Anne-Pauline, Bonnal, Christine, Bonhomme, Julie, Botterel, Françoise, Bougnoux, Marie-Elisabeth, Brun, Sophie, Chouaki, Taieb, Cornet, Muriel, Dannaoui, Eric, Demar, Magalie, Desbois-Nogard, Nicole, Durieux, Marie-Fleur, Favennec, Loïc, Fekkar, Arnaud, and Gabriel, Frederic

Subjects
HIV, CRYPTOCOCCUS neoformans, SYMPTOMS, CRYPTOCOCCOSIS, HIV status
Abstract

Among 1107 cryptococcosis cases from the French surveillance network (2005–2020), the proportion of HIV-seronegative individuals has recently surpassed that of HIV-seropositive individuals. We observed marked differences in patient characteristics, disease presentations, cryptococcal antigen results, infecting species, and mortality according to HIV serostatus. [ABSTRACT FROM AUTHOR]

Published
2024
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19. ACTUALITÉ DE LA RECHERCHE

Author

Cernogora, Nadia, Gabriel, Frédéric, Grintchenko, Marie-Hélène, Lestringant, Frank, Kirschleger, Pierre-Yves, and Ullberg, Anne

Published
2006

22. Invasive aspergillosis due to Aspergillus cryptic species: A prospective multicentre study

Author

Imbert, Sebastien, primary, Cassaing, Sophie, additional, Bonnal, Christine, additional, Normand, Anne‐Cecile, additional, Gabriel, Frederic, additional, Costa, Damien, additional, Blaize, Marion, additional, Lachaud, Laurence, additional, Hasseine, Lilia, additional, Kristensen, Lise, additional, Guitard, Juliette, additional, Schuttler, Christine, additional, Raberin, Helene, additional, Brun, Sophie, additional, Hendrickx, Marijke, additional, Piarroux, Renaud, additional, and Fekkar, Arnaud, additional

Published
2021
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24. Differential degradation of nonylphenol isomers by Sphingomonas xenophaga Bayram

Author

Gabriel, Frederic L. P., Giger, Walter, Guenther, Klaus, and Kohler, Hans-Peter E.

Subjects
Biodegradation -- Research, Phenols -- Research, Biological sciences
Abstract

The isolation of an Sphingomonas xenophaga Bayram strain that efficiently degrades 4-(1-ethyl-1,4-dimethylpentyl)phenol is reported. The degradation experiments with five different 4-nonylphenol isomers have indicated that degradability is strongly dependent on the structure of the alkyl substituent.

Published
2005

25. Epidemiology and Clinical Impact of Respiratory Coinfections at Diagnosis of Pneumocystis jirovecii Pneumonia.

Author

Lécuyer, Romain, Issa, Nahema, Tessoulin, Benoit, Lavergne, Rose-Anne, Morio, Florent, Gabriel, Frederic, Canet, Emmanuel, Bressollette-Bodin, Céline, Guillouzouic, Aurélie, Boutoille, David, Raffi, François, Lecomte, Raphael, Turnier, Paul Le, Deschanvres, Colin, Camou, Fabrice, Gaborit, Benjamin Jean, Group, PRONOCYSTIS Study, Le Turnier, Paul, and PRONOCYSTIS Study Group

Subjects
PNEUMOCYSTIS pneumonia, MIXED infections, CLINICAL epidemiology, DIAGNOSIS, ODDS ratio, HIV infection epidemiology, HIV infection complications, CYTOMEGALOVIRUS disease diagnosis, CYTOMEGALOVIRUSES, CYTOMEGALOVIRUS diseases, FUNGI, RETROSPECTIVE studies, DISEASE complications
Abstract

Background: The role of respiratory coinfections at diagnosis of Pneumocystis jirovecii pneumonia (PcP) on clinical impact has been underestimated.Methods: A retrospective observational study was conducted January 2011 to April 2019 to evaluate respiratory coinfections at diagnosis of PcP patients in 2 tertiary care hospitals. Coinfection was defined by identification of pathogens from P. jirovecii-positive samples.Results: Of 7882 respiratory samples tested for P. jirovecii during the 8-year study, 328 patients with diagnosis of PcP were included. Mean age was 56.7 (SD 14.9) years, 193 (58.8%) were male, 74 (22.6%) had positive HIV serology, 125 (38.1%) had viral coinfection, 76 (23.2%) bacterial coinfection, and 90-day mortality was 25.3%. In the overall population, 90-day mortality was independently associated with solid tumor underlying disease (odds ratio [OR], 11.8; 95% confidence interval [CI], 1.90-78.0; P = .008), sepsis-related organ failure assessment score (SOFA) at admission (OR, 1.62; 95% CI, 1.34-2.05; P< .001), and cytomegalovirus (CMV) respiratory coinfection (OR, 3.44; 95% CI, 1.24-2.90; P = .02). Among HIV-negative patients, respiratory CMV coinfection was associated with worse prognosis, especially when treated with adjunctive corticosteroid therapy.Conclusions: Respiratory CMV coinfection at PcP diagnosis was independently associated with increased 90-day mortality, specifically in HIV-negative patients. [ABSTRACT FROM AUTHOR]

Published
2022
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26. Invasive Aspergillosis Due to Aspergillus Section Usti: A Multicenter Retrospective Study

Author

Glampedakis, Emmanouil, primary, Cassaing, Sophie, additional, Fekkar, Arnaud, additional, Dannaoui, Eric, additional, Bougnoux, Marie-Elisabeth, additional, Bretagne, Stéphane, additional, Neofytos, Dionysios, additional, Schreiber, Peter W, additional, Hennequin, Christophe, additional, Morio, Florent, additional, Shadrivova, Olga, additional, Bongomin, Felix, additional, Fernández-Ruiz, Mario, additional, Bellanger, Anne Pauline, additional, Arikan-Akdagli, Sevtap, additional, Erard, Veronique, additional, Aigner, Maria, additional, Paolucci, Michela, additional, Khanna, Nina, additional, Charpentier, Eléna, additional, Bonnal, Christine, additional, Brun, Sophie, additional, Gabriel, Frederic, additional, Riat, Arnaud, additional, Zbinden, Reinhard, additional, Le Pape, Patrice, additional, Klimko, Nikolai, additional, Lewis, Russel E, additional, Richardson, Malcolm, additional, İnkaya, Ahmet Cagkan, additional, Coste, Alix T, additional, Bochud, Pierre-Yves, additional, and Lamoth, Frederic, additional

Published
2020
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29. Characteristics and Prognosis Factors of Pneumocystis jiroveciiPneumonia According to Underlying Disease

Author

Lécuyer, Romain, Issa, Nahéma, Camou, Fabrice, Lavergne, Rose-anne, Gabriel, Frederic, Morio, Florent, Canet, Emmanuel, Raffi, François, Boutoille, David, Cady, Anne, Gousseff, Marie, Crabol, Yoann, Néel, Antoine, Tessoulin, Benoît, Gaborit, Benjamin, Raffi, Francois, Boutoille, David, Biron, Charlotte, Lefebvre, Maeva, Gaborit, Benjamin Jean, Le Turnier, Paul, Deschanvres, Colin, Lecomte, Raphael, Chauveau, Marie, Lécuyer, Romain, Asquier-Khati, Antoine, Le Pape, Patrice, Morio, Florent, Lavergne, Rose-Anne, Jeddi, Fakhri, Corvec, Stéphane, Bemer, Pascale, Caillon, Jocelyne, Guillouzouic, Aurélie, Leroy, Anne-Gaëlle, Lakhal, Karim, Cinotti, Raphaël, Roquilly, Antoine, Emmanuel Canet, Jean Reignier, Blanc, François Xavier, Bretonniere, Cédric, Morin, Paul, Camou, Fabrice, Issa, Nahéma, Guisset, Olivier, Mourissoux, Gaelle, Accoceberry, Isabelle, Gabriel, Frederic, Accoceberry, Isabelle, Coron, Noémie, Delhaes, Laurence, Imbert, Sébastien, Lefranc, Maxime, Lussac-Sorton, Florian, Rougeron, Amandine, Gousseff, Marie, Crabol, Yoann, Corvaisier, Grégory, Lautredoux, Florent, Lécuyer, Romain, Cady, Anne, Auger, Myriam, and Pouedras, Pascal

Abstract

Pneumocystis jiroveciipneumonia (PcP) remains associated with high rates of mortality, and the impact of immunocompromising underlying disease on the clinical presentation, severity, and mortality of PcP has not been adequately evaluated.

Published
2024
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30. Evaluation of a New Histoplasmaspp. Quantitative RT-PCR Assay

Author

Alanio, Alexandre, Gits-Muselli, Maud, Lanternier, Fanny, Sturny-Leclère, Aude, Benazra, Marion, Hamane, Samia, Rodrigues, Anderson Messias, Garcia-Hermoso, Dea, Lortholary, Olivier, Dromer, Françoise, Bretagne, Stéphane, Woimant, Marine Gosset, blanchard, Geneviève, Silhadi, Souad, Vignier, Nicolas, Pitsch, Aurelia, Jidar, Kaoutar, Traversier, Nicolas, Poisson, Didier, Lecointre, Claire, Foulet, Françoise, Botterel, Françoise, Ammar, Nawel Ait, Amsellem, Gabriel, Frederic, Poirier, Philipe, Cornu, Marjorie, Loridant, Severine, Morio, Florent, Boutoille, David, Jeddi, Fakhri, Hasseine, Lilia, Ouissa, Rachida, Toubas, Dominique, Bailly, Eric, Désoubeaux, Guillaume, Ronez, Emily, Foulon, Guillaume, Lefrançois, Sebastien, Bonnal, Christine, Paugam, André, Dougados, Maxime, Desroches, Marine, Barazzutti, Hélène, Paleiron, Nicolas, rabodonirina, Meja, Catherinot, Emilie, Cardot-Martin, Emilie, Hiesse, Chrisian, Salvator, Hélène, Aguilar, Claire, Gigandon, Anne, de Montpreville, Thomas, Bougnoux, Marie-Elisabeth, Sitterlé, Emilie, Fekkar, Arnaud, Imbert, Sébastien, Bleibtreu, Alexandre, Senghor, Yaye, Denis, Blandine, Molina, Jean-Michel, Liegeon, Geoffroy, Munnier, Anne-Lise, Malphettes, Marion, Denis, Julie, Berlioz-Arthaud, Alain, Lange, Franciska, Chiaruzzi, Myriam, and Epelboin, Loic

Abstract

Laboratory diagnosis of histoplasmosis is based on various methods, including microscopy, culture, antigen, and DNA detection of Histoplasma capsulatumvar. capsulatumor Histoplasma capsulatumvar. duboisii. To improve sensitivity of existing real-time quantitative PCR (qPCR) assays, we developed a new RT-qPCR assay that allows amplification of whole nucleic acids of Histoplasmaspp. validated on suspected cases. The limit of detection was 20 copies, and the specificity against 114 fungal isolates/species was restricted to Histoplasmaspp. Whole nucleic acids of 1319 prospectively collected consecutive samples from 907 patients suspected of having histoplasmosis were tested routinely between May 2015 and May 2019 in parallel with standard diagnostic procedures performed in parallel. Forty-four had proven histoplasmosis attributable to H. capsulatumvar. capsulatum(n= 40) or H. capsulatumvar. duboisii(n= 4) infections. The results of RT-qPCR were positive in 43 of 44 patients (97.7% sensitivity) in at least one specimen. Nine of 863 cases (99% specificity) were RT-qPCR positive and therefore classified as possible cases. RT-qPCR was positive in 13 of 30 (43.3%) blood samples tested in proven cases. A positive RT-qPCR result in blood was significantly associated with H. capsulatumvar. capsulatumprogressively disseminated histoplasmosis with a positive RT-qPCR result in 92.3% of the immunocompromised patients with disseminated disease. This new HistoplasmaRT-qPCR assay enabling amplification of H. capsulatumvar. capsulatumand H. capsulatumvar. duboisiiis highly sensitive and allows the diagnosis of histoplasmosis advantageously from blood and bronchoalveolar lavage fluid.

Published
2021
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32. Quantitative PCR (qPCR) Detection of Mucorales DNA in Bronchoalveolar Lavage Fluid To Diagnose Pulmonary Mucormycosis

Author

Scherer, Emeline, primary, Iriart, Xavier, additional, Bellanger, Anne Pauline, additional, Dupont, Damien, additional, Guitard, Juliette, additional, Gabriel, Frederic, additional, Cassaing, Sophie, additional, Charpentier, Eléna, additional, Guenounou, Sarah, additional, Cornet, Murielle, additional, Botterel, Françoise, additional, Rocchi, Steffi, additional, Berceanu, Ana, additional, and Millon, Laurence, additional

Published
2018
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33. Breakthrough invasive aspergillosis and diagnostic accuracy of serum galactomannan enzyme immune assay during acute myeloid leukemia induction chemotherapy with posaconazole prophylaxis

Author

Calmettes, Claire, primary, Gabriel, Frederic, additional, Blanchard, Elodie, additional, Servant, Vincent, additional, Bouchet, Stéphane, additional, Kabore, Nathanael, additional, Forcade, Edouard, additional, Leroyer, Camille, additional, Bidet, Audrey, additional, Latrabe, Valérie, additional, Leguay, Thibaut, additional, Vigouroux, Stephane, additional, Tabrizi, Reza, additional, Breilh, Dominique, additional, Accoceberry, Isabelle, additional, de Lara, Manuel Tunon, additional, Pigneux, Arnaud, additional, Milpied, Noel, additional, and Dumas, Pierre-Yves, additional

Published
2018
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34. Elucidation of the ipso-substitution mechanism for side-chain cleavage of alpha-quaternary 4-nonylphenols and 4-t-butoxyphenol in sphingobium xenophagum bayram

Author

Gabriel, Frederic L.P., Cyris, Maike, Jonkers, Niels, Giger, Walter, Guenther, Klaus, and Kohler, Hans-Peter E.

Subjects
Biodegradation -- Analysis, Hydroxylation -- Analysis, Polyphenols -- Chemical properties, Soil microbiology -- Research, Biological sciences
Abstract

Study is conducted using O-labeling experiments to demonstrate that the ipso-hydroxy group is derived from molecular oxygen. The results shows that the alkyl cation derived from the alpha-quatermary nonylphenol 4-(1-ethyl-1,4-dimethyl-pentyl)-phenol through ipso-hydroxylation.

Published
2007

44. Identification en ligne des agents fongiques par spectrométrie de masse et détection d’espèces émergentes

Author

Normand, Anne-Cécile, Cassagne, Carole, Hasseine, Lilia, Gari-Toussaint, Martine, Gabriel, Frédéric, Accoceberry, Isabelle, Costa, Damien, Bourgeois, Nathalie, Cassaing, Sophie, Nabet, Cécile, Bonnal, Christine, Raberin, Hélène, Stein, Markus, Surmont, Ignace, Pierard, Denis, Djenad, Farid, Donnadieu, Jean-Luc, Piarroux, Martine, Ranque, Stéphane, Becker, Pierre, Hendrickx, Marijke, and Piarroux, Renaud

Published
2017
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50. Lindnera (Pichia) fabianii blood infection after mesenteric ischemia.

Author

Gabriel, Frederic, Noel, Thierry, and Accoceberry, Isabelle

Abstract

Lindnera (Pichia) fabianii (teleomorph of Candida fabianii) is a yeast species rarely involved in human infections. This report describes the first known human case of a Lindnera fabianii blood infection after mesenteric ischemia. The 53-year-old patient was hospitalized in the intensive care unit after a suicide attempt and was suffering from a mesenteric ischemia and acute renal failure. Lindnera fabianii was recovered from an oropharyngeal swab, then isolated from stool and urine samples before the diagnosis of the blood infection. Caspofungin intravenous treatment was associated with a successful outcome. Final unequivocal identification of the strain was done by sequencing the internal transcribed spacer (ITS) region, and regions of 18S rDNA gene and of the translation elongation factor-1α gene. Until our work, the genomic databases did not contain the complete ITS region of L. fabianii as a single nucleotide sequence (encompassing ITS1, the 5.8S rDNA and ITS2), and misidentification with other yeast species, e.g., Lindnera (Pichia) mississippiensis, could have occurred. Our work demonstrates that the usual DNA barcoding method based on sequencing of the ITS region may fail to provide the correct identification of some taxa, and that partial sequencing of the EF1α gene may be much more effective for the accurate delineation and molecular identification of new emerging opportunistic yeast pathogens. [ABSTRACT FROM AUTHOR]

Published
2012
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