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11 results on '"Gaborit, Benjamin Jean"'

1. Characteristics and Prognosis Factors of Pneumocystis jirovecii Pneumonia According to Underlying Disease: A Retrospective Multicenter Study

Author

Raffi, Francois, Boutoille, David, Biron, Charlotte, Lefebvre, Maeva, Gaborit, Benjamin Jean, Le Turnier, Paul, Deschanvres, Colin, Lecomte, Raphael, Chauveau, Marie, Lécuyer, Romain, Asquier-Khati, Antoine, Le Pape, Patrice, Morio, Florent, Lavergne, Rose-Anne, Jeddi, Fakhri, Corvec, Stéphane, Bemer, Pascale, Caillon, Jocelyne, Guillouzouic, Aurélie, Leroy, Anne-Gaëlle, Lakhal, Karim, Cinotti, Raphaël, Roquilly, Antoine, Emmanuel Canet, Jean Reignier, Blanc, François Xavier, Bretonniere, Cédric, Morin, Paul, Camou, Fabrice, Issa, Nahéma, Guisset, Olivier, Mourissoux, Gaelle, Accoceberry, Isabelle, Gabriel, Frederic, Coron, Noémie, Delhaes, Laurence, Imbert, Sébastien, Lefranc, Maxime, Lussac-Sorton, Florian, Rougeron, Amandine, Gousseff, Marie, Crabol, Yoann, Corvaisier, Grégory, Lautredoux, Florent, Cady, Anne, Auger, Myriam, Pouedras, Pascal, Lavergne, Rose-anne, Canet, Emmanuel, Raffi, François, Néel, Antoine, Tessoulin, Benoît, and Gaborit, Benjamin

Published
2024
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2. Should We Reconsider PneumocystisPneumonia Presentation and Treatment According to Its Underlying Disease?

Author

Gaborit, Benjamin, Lécuyer, Romain, Issa, Nahéma, Camou, Fabrice, Lavergne, Rose-anne, Gabriel, Frederic, Morio, Florent, Canet, Emmanuel, Raffi, François, Boutoille, David, Cady, Anne, Gousseff, Marie, Crabol, Yoann, Néel, Antoine, Tessoulin, Benoît, Raffi, Francois, Boutoille, David, Biron, Charlotte, Lefebvre, Maeva, Gaborit, Benjamin Jean, Le Turnier, Paul, Deschanvres, Colin, Lecomte, Raphael, Chauveau, Marie, Lécuyer, Romain, Asquier-Khati, Antoine, Pineau, Valentin, Prime, Marie, Delaunay, Clarisse, Essid, Hakim, Le Pape, Patrice, Morio, Florent, Lavergne, Rose-Anne, Jeddi, Fakhri, Corvec, Stéphane, Bemer, Pascale, Caillon, Jocelyne, Guillouzouic, Aurélie, Leroy, Anne-Gaëlle, Lakhal, Karim, Cinotti, Raphaël, Roquilly, Antoine, Jean Reignier, Mickael Vourc’h;, Canet, Emmanuel, Blanc, François Xavier, Bretonniere, Cédric, Morin, Jean, Le Blanc, Camille, Alami, Hakim, Camou, Fabrice, Issa, Nahéma, Guisset, Olivier, Mourissoux, Gaelle, Accoceberry, Isabelle, Gabriel, Frederic, Coron, Noémie, Delhaes, Laurence, Imbert, Sébastien, Lefranc, Maxime, Lussac-Sorton, Florian, Rougeron, Amandine, Gousseff, Marie, Crabol, Yoann, Corvaisier, Grégory, Lautredoux, Florent, Anne Cady, Romain Lécuyerand, Auger, Myriam, and Pouedras, Pascal

Published
2024
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3. Should We Reconsider Pneumocystis Pneumonia Presentation and Treatment According to Its Underlying Disease?: An Unsupervised Cluster Analysis of a Retrospective Multicenter Study

Author

Raffi, Francois, Boutoille, David, Biron, Charlotte, Lefebvre, Maeva, Gaborit, Benjamin Jean, Le Turnier, Paul, Deschanvres, Colin, Lecomte, Raphael, Chauveau, Marie, Lécuyer, Romain, Asquier-Khati, Antoine, Pineau, Valentin, Prime, Marie, Delaunay, Clarisse, Essid, Hakim, Le Pape, Patrice, Morio, Florent, Lavergne, Rose-Anne, Jeddi, Fakhri, Corvec, Stéphane, Bemer, Pascale, Caillon, Jocelyne, Guillouzouic, Aurélie, Leroy, Anne-Gaëlle, Lakhal, Karim, Cinotti, Raphaël, Roquilly, Antoine, Jean Reignier, Mickael Vourc’h, Canet, Emmanuel, Blanc, François Xavier, Bretonniere, Cédric, Morin, Jean, Le Blanc, Camille, Alami, Hakim, Camou, Fabrice, Issa, Nahéma, Guisset, Olivier, Mourissoux, Gaelle, Accoceberry, Isabelle, Gabriel, Frederic, Coron, Noémie, Delhaes, Laurence, Imbert, Sébastien, Lefranc, Maxime, Lussac-Sorton, Florian, Rougeron, Amandine, Gousseff, Marie, Crabol, Yoann, Corvaisier, Grégory, Lautredoux, Florent, Anne Cady, Romain Lécuyerand, Auger, Myriam, Pouedras, Pascal, Gaborit, Benjamin, Lavergne, Rose-anne, Raffi, François, Cady, Anne, Néel, Antoine, and Tessoulin, Benoît

Published
2024
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4. Outcome and prognostic factors of Pneumocystis jirovecii pneumonia in immunocompromised adults: a prospective observational study

Author

Gaborit, Benjamin Jean, Tessoulin, Benoit, Lavergne, Rose-Anne, Morio, Florent, Sagan, Christine, Canet, Emmanuel, Lecomte, Raphael, Leturnier, Paul, Deschanvres, Colin, Khatchatourian, Lydie, Asseray, Nathalie, Garret, Charlotte, Vourch, Michael, Marest, Delphine, Raffi, François, Boutoille, David, and Reignier, Jean

Published
2019
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6. Plea for multitargeted interventions for severe COVID-19

Author

Gaborit, Benjamin Jean, primary, Bergmann, Jean-François, additional, Mussini, Cristina, additional, Arribas, Jose Ramon, additional, Behrens, Georg, additional, Walmsley, Sharon, additional, Pozniak, Anton, additional, and Raffi, François, additional

Published
2020
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7. Should we reconsider cefazolin for treating staphylococcal meningitis? A retrospective analysis of cefazolin and cloxacillin cerebrospinal fluid levels in patients treated for staphylococcal meningitis

Author

Le Turnier, P., primary, Gregoire, M., additional, Deslandes, G., additional, Lakhal, K., additional, Deschanvres, C., additional, Lecomte, R., additional, Talarmin, J.-P., additional, Dubée, V., additional, Bellouard, R., additional, Boutoille, D., additional, Leroy, A.-G., additional, Gaborit, B.J., additional, Raffi, Francois, additional, Boutoille, David, additional, Biron, Charlotte, additional, Lefebvre, Maeva, additional, Gaborit, Benjamin Jean, additional, Le Turnier, Paul, additional, Deschanvres, Colin, additional, Lecomte, Raphael, additional, Chauveau, Marie, additional, Asseray, Nathalie, additional, Gregoire, Matthieu, additional, Bellouard, Ronan, additional, Deslandes, Guillaume, additional, Dailly, Eric, additional, Leroy, Anne-Gaëlle, additional, Corvec, Stéphane, additional, Bémer, Pascale, additional, Caillon, Jocelyne, additional, Guillouzouic, Aurélie, additional, Lakhal, Karim, additional, Cinotti, Raphaël, additional, Canet, Emmanuel, additional, Bretonniere, Cédric, additional, Guimard, Thomas, additional, Brochard, Julia, additional, Talarmin, Jean Philippe, additional, and Katchatourian, Lydie, additional

Published
2020
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8. Epidemiology and Clinical Impact of Respiratory Coinfections at Diagnosis of Pneumocystis jirovecii Pneumonia.

Author

Lécuyer, Romain, Issa, Nahema, Tessoulin, Benoit, Lavergne, Rose-Anne, Morio, Florent, Gabriel, Frederic, Canet, Emmanuel, Bressollette-Bodin, Céline, Guillouzouic, Aurélie, Boutoille, David, Raffi, François, Lecomte, Raphael, Turnier, Paul Le, Deschanvres, Colin, Camou, Fabrice, Gaborit, Benjamin Jean, Group, PRONOCYSTIS Study, Le Turnier, Paul, and PRONOCYSTIS Study Group

Subjects
PNEUMOCYSTIS pneumonia, MIXED infections, CLINICAL epidemiology, DIAGNOSIS, ODDS ratio, HIV infection epidemiology, HIV infection complications, CYTOMEGALOVIRUS disease diagnosis, CYTOMEGALOVIRUSES, CYTOMEGALOVIRUS diseases, FUNGI, RETROSPECTIVE studies, DISEASE complications
Abstract

Background: The role of respiratory coinfections at diagnosis of Pneumocystis jirovecii pneumonia (PcP) on clinical impact has been underestimated.Methods: A retrospective observational study was conducted January 2011 to April 2019 to evaluate respiratory coinfections at diagnosis of PcP patients in 2 tertiary care hospitals. Coinfection was defined by identification of pathogens from P. jirovecii-positive samples.Results: Of 7882 respiratory samples tested for P. jirovecii during the 8-year study, 328 patients with diagnosis of PcP were included. Mean age was 56.7 (SD 14.9) years, 193 (58.8%) were male, 74 (22.6%) had positive HIV serology, 125 (38.1%) had viral coinfection, 76 (23.2%) bacterial coinfection, and 90-day mortality was 25.3%. In the overall population, 90-day mortality was independently associated with solid tumor underlying disease (odds ratio [OR], 11.8; 95% confidence interval [CI], 1.90-78.0; P = .008), sepsis-related organ failure assessment score (SOFA) at admission (OR, 1.62; 95% CI, 1.34-2.05; P< .001), and cytomegalovirus (CMV) respiratory coinfection (OR, 3.44; 95% CI, 1.24-2.90; P = .02). Among HIV-negative patients, respiratory CMV coinfection was associated with worse prognosis, especially when treated with adjunctive corticosteroid therapy.Conclusions: Respiratory CMV coinfection at PcP diagnosis was independently associated with increased 90-day mortality, specifically in HIV-negative patients. [ABSTRACT FROM AUTHOR]

Published
2022
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9. Development and validation of a dosing nomogram for amoxicillin in infective endocarditis.

Author

Rambaud, Antoine, Gaborit, Benjamin Jean, Deschanvres, Colin, Turnier, Paul Le, Lecomte, Raphaël, Asseray-Madani, Nathalie, Leroy, Anne-Gaëlle, Deslandes, Guillaume, Dailly, Éric, Jolliet, Pascale, Boutoille, David, Bellouard, Ronan, Gregoire, Matthieu, group, the Nantes Anti-Microbial Agents PK/PD (NAMAP) study, Le Turnier, Paul, and Nantes Anti-Microbial Agents PK/PD (NAMAP) study group

Subjects
*INFECTIVE endocarditis, *NOMOGRAPHY (Mathematics), *BODY surface area, *GLOMERULAR filtration rate, *BLOOD proteins, *AMOXICILLIN
Abstract

Background: Amoxicillin is the first-line treatment for streptococcal or enterococcal infective endocarditis (IE) with a dose regimen adapted to weight.Objectives: Covariates influencing pharmacokinetics (PK) of amoxicillin were identified in order to develop a dosing nomogram based on identified covariates for individual adaptation.Patients and Methods: Patients treated with amoxicillin administered by continuous infusion for IE were included retrospectively. The population PK analysis was performed using the Pmetrics package for R (NPAG algorithm). Influence of weight, ideal weight, height, BMI, body surface area, glomerular filtration rate adapted to the body surface area and calculated by the CKD-EPI method (mL/min), additional ceftriaxone treatment and serum protein level on amoxicillin PK was tested. A nomogram was then developed to determine the daily dose needed to achieve a steady-state free plasma concentration above 4× MIC, 100% of the time, without exceeding a total plasma concentration of 80 mg/L.Results: A total of 160 patients were included. Population PK analysis was performed on 540 amoxicillin plasma concentrations. A two-compartment model best described amoxicillin PK and the glomerular filtration rate covariate significantly improved the model when included in the calculation of the elimination constant Ke.Conclusions: This work allowed the development of a dosing nomogram that can help to increase achievement of the PK/pharmacodynamic targets in IE treated with amoxicillin. [ABSTRACT FROM AUTHOR]

Published
2020
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10. Should we reconsider cefazolin for treating staphylococcal meningitis? A retrospective analysis of cefazolin and cloxacillin cerebrospinal fluid levels in patients treated for staphylococcal meningitis

Author

Raffi, Francois, Boutoille, David, Biron, Charlotte, Lefebvre, Maeva, Gaborit, Benjamin Jean, Le Turnier, Paul, Deschanvres, Colin, Lecomte, Raphael, Chauveau, Marie, Asseray, Nathalie, Gregoire, Matthieu, Bellouard, Ronan, Deslandes, Guillaume, Dailly, Eric, Leroy, Anne-Gaëlle, Corvec, Stéphane, Bémer, Pascale, Caillon, Jocelyne, Guillouzouic, Aurélie, Lakhal, Karim, Cinotti, Raphaël, Canet, Emmanuel, Bretonniere, Cédric, Guimard, Thomas, Brochard, Julia, Talarmin, Jean Philippe, Katchatourian, Lydie, Le Turnier, P., Gregoire, M., Deslandes, G., Lakhal, K., Deschanvres, C., Lecomte, R., Talarmin, J.-P., Dubée, V., Bellouard, R., Boutoille, D., Leroy, A.-G., and Gaborit, B.J.

Published
2020
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11. Characteristics and Prognosis Factors of Pneumocystis jiroveciiPneumonia According to Underlying Disease

Author

Lécuyer, Romain, Issa, Nahéma, Camou, Fabrice, Lavergne, Rose-anne, Gabriel, Frederic, Morio, Florent, Canet, Emmanuel, Raffi, François, Boutoille, David, Cady, Anne, Gousseff, Marie, Crabol, Yoann, Néel, Antoine, Tessoulin, Benoît, Gaborit, Benjamin, Raffi, Francois, Boutoille, David, Biron, Charlotte, Lefebvre, Maeva, Gaborit, Benjamin Jean, Le Turnier, Paul, Deschanvres, Colin, Lecomte, Raphael, Chauveau, Marie, Lécuyer, Romain, Asquier-Khati, Antoine, Le Pape, Patrice, Morio, Florent, Lavergne, Rose-Anne, Jeddi, Fakhri, Corvec, Stéphane, Bemer, Pascale, Caillon, Jocelyne, Guillouzouic, Aurélie, Leroy, Anne-Gaëlle, Lakhal, Karim, Cinotti, Raphaël, Roquilly, Antoine, Emmanuel Canet, Jean Reignier, Blanc, François Xavier, Bretonniere, Cédric, Morin, Paul, Camou, Fabrice, Issa, Nahéma, Guisset, Olivier, Mourissoux, Gaelle, Accoceberry, Isabelle, Gabriel, Frederic, Accoceberry, Isabelle, Coron, Noémie, Delhaes, Laurence, Imbert, Sébastien, Lefranc, Maxime, Lussac-Sorton, Florian, Rougeron, Amandine, Gousseff, Marie, Crabol, Yoann, Corvaisier, Grégory, Lautredoux, Florent, Lécuyer, Romain, Cady, Anne, Auger, Myriam, and Pouedras, Pascal

Abstract

Pneumocystis jiroveciipneumonia (PcP) remains associated with high rates of mortality, and the impact of immunocompromising underlying disease on the clinical presentation, severity, and mortality of PcP has not been adequately evaluated.

Published
2024
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