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2. The Italian dementia with Lewy bodies study group (DLB-SINdem): toward a standardization of clinical procedures and multicenter cohort studies design

Author

Bonanni, L., Cagnin, A., Agosta, F., Babiloni, C., Borroni, B., Bozzali, M., Bruni, A. C., Filippi, M., Galimberti, D., Monastero, R., Muscio, C., Parnetti, L., Perani, D., Serra, L., Silani, V., Tiraboschi, P., Padovani, A., Alberici, A., Alberoni, M., Amici, S., Appollonio, I., Arena, M.G., Arighi, A., Avanzi, S., Bagella, C.F., Baglio, F., Barocco, F., Belardinelli, N., Bonuccelli, U., Bottini, G., Bruno Bossio, R., Bruno, G., Buccomino, D., Cacchiò, G., Calabrese, E., Campanelli, A., Canevelli, M., Canu, E.D.G., Cappa, A., Capra, C., Carapelle, E., Caratozzolo, S., Carbone, G.F.S., Cattaruzza, T., Cerami, C., Cester, A., Cheldi, A., Cherchi, R., Chiari, A., Cirafisi, C., Colao, R., Confaloni, A., Conti, M.Z., Costa, A., Costa, B., Cotelli, M.S., Cova, I., Cravello, L., Cumbo, E., Cupidi, C., De Togni, L., Del Din, G., Del Re, M.L., Dentizzi, C., Di Lorenzo, F., Di Stefano, F., Dikova, N., Farina, E., Floris, G., Foti, A., Franceschi, M., Fumagalli, G.G., Gabelli, C., Ghidoni, E., Giannandrea, D., Giordana, M.T., Giorelli, M., Giubilei, F., Grimaldi, L., Grimaldi, R., Guglielmi, V., Lanari, A., Le Pira, F., Letteri, F., Levi Minzi, G.V., Lorusso, S., Ludovico, L., Luzzi, S., Maggiore, L., Magnani, G., Mancini, G., Manconi, F.M., Manfredi, L., Maniscalco, M., Marano, P., Marcon, M., Marcone, A., Marra, C., Martorana, A., Mascia, M.G., Mascia, V., Mauri, M., Mazzei, B., Meloni, M., Merlo, P., Messa, G., Milia, A., Monacelli, F., Montecalvo, G., Moschella, V., Mura, G., Nemni, R., Nobili, F., Notarelli, A., Di Giacomo, R., Onofrj, M., Paci, C., Padiglioni, C., Perini, M., Perotta, D., Perri, Formenti A., Perri, R., Piccininni, C., Piccoli, T., Pilia, G., Pilotto, A., Poli, S., Pomati, S., Pompanin, S., Pucci, E., Puccio, G., Quaranta, D., Rainero, I., Rea, G., Realmuto, S., Riva, M., Rizzetti, M.C., Rolma, G., Rozzini, L., Sacco, L., Saibene, F.L., Scarpini, E., Sensi, S., Seripa, D., Sinforiani, E., Sorbi, S., Sorrentino, G., Spallazzi, M., Stracciari, A., Talarico, G., Tassinari, T., Thomas, A., Tiezzi, A., Tomassini, P.F., Trebbastoni, A., Tremolizzo, L., Tripi, G., Ursini, F., Vaianella, L., Valluzzi, F., Vezzadini, G., Vista, M., Volontè, M.A., On behalf of DLB-SINdem study group, and Istituto Superiore di Sanità

Published
2017
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3. The Italian fund for Alzheimer's and other dementias: strategies and objectives to face the dementia challenge

Author

Ancidoni, A., Sciancalepore, F., Bacigalupo, I., Bellomo, G., Canevelli, M., Lacorte, E., Lombardo, F. L., Lorenzini, P., Palazzesi, I., Piscopo, P., Salvi, E., Bianchi, C. B. N. A., Landoni, F., La Sala, L., Di Fiandra, T., Vanacore, N., Basso, C., Bonino, P., Bruni, A. C., Caci, A., Fabbo, A., Giordano, M., Greco, A., Lidonnici, E., Lombardi, A., Lovaldi, F., March, A., Madrigali, S., Palummeri, E., Perratone, P., Scalmana, S., Caffarra, P., Mazzoleni, F., Pirani, A., Trabucchi, M., Belardinelli, M., Possenti, M., Spadin, P., Bargagli, A. M., Bartorelli, L., Biagini, C., Capasso, A., Cozzari, M. P., Gainotti, S., Di Palma, A., Gabelli, C., Gambina, G., Gasparini, M. M., Guaita, A., Izzicupo, F., Notarelli, A., Petrini, C., Riva, L., Secreto, P., Stracciari, A., Losito, G., Ciampa, A., Camilli, F. -M., Carnevale, G., Coclite, D., Crestini, A., Della Gatta, F., Distaso, E., Druda, Y., Esposito, S., Fabrizi, E., Fauci, A., Fumagalli, G., Gasparini, M., Giaquinto, F., Locuratolo, N., Lombardo, F., Martelli, G., Matascioli, F., Mennini, S., Milanese, A., Morelli, S., Napoletano, A., Porrello, M. C., Remoli, G., Rivabene, R., Sagliocca, L., Sciattella, P., Vaccaro, R., Valletta, M., Veronese, N., Vignatelli, L., and Zaccaria, V.

Subjects
Caregivers, Financial Management, Alzheimer Disease, public health, Humans, Dementia, dementia national plan, Public Health, dementia, caregivers, humans, alzheimer disease, financial management
Abstract

The Italian Fund for Alzheimer's and other dementias was approved and signed in December 2021. The Fund is financed with 15 million euros in three years. The main goal is to provide new strategies in the field of dementia with a Public Health perspective. The Fund includes eight main activities that will be monitored and supervised by the Italian National Institute of Health: 1) development of a guideline for the assessment, management and support for people with dementia and their families/carers; 2) updating of the Dementia National Plan (DNP); 3) implementation of the documents of the DNP; 4) conducting surveys dedicated to the Italian Dementia Services; 5) promotion of dementia prevention strategies; 6) training strategies for healthcare professionals, families and caregivers; 7) creation of a National Electronic Record for Dementia; 8) evaluation and monitoring of activities promoted by Regions and Autonomous Provinces in the field of dementia, together with the dementia National Permanent Table. These activities are outlined in detail in the present paper.

Published
2022

5. The association of indwelling urinary catheter with delirium in hospitalized patients and nursing home residents: an explorative analysis from the 'Delirium Day 2015'

Author

Bo, M, Porrino, P, Di Santo SG, Mazzone, A, Cherubini, A, Mossello, E, Bianchetti, A, Musicco, M, Ferrari, A, Ferrara, N, Filippini, C, Trabucchi, M, Morandi, A, Bellelli, G, on behalf of the Italian Study Group on Delirium (ISGoD): Boffelli, S, Di Stefano, F, De Filippi, F, Guerini, F, Bertoletti, E, March, A, Margiotta, A, Mecocci, P, Ruggiero, C, Addesi, D, Fantò, F, Isaia, G, Dijik, B, Cotroneo, Am, Galli, G, Bruni, Ac, Bernardini, B, Corsini, C, Cagnin, A, Zurlo, G, Barbagallo, G, Lunardelli, Ml, Martini, E, Battaglia, G, Latella, R, Petritola, D, Sinforiani, E, Cester, A, Formilan, M, Carbone, P, Appollonio, I, Cereda, D, Tremolizzo, L, Bottacchi, E, Lucchetti, L, Mariani, C, Rapazzini, P, Romanelli, G, Marengoni, A, Zuliani, G, Bianchi, L, Suardi, T, Muti, E, Bottura, R, Sgrò, G, Mandas, A, Serchisu, L, Crippa, P, Ivaldi, C, Ungar, A, Villani, D, Raimondi, C, Mussi, C, Provenzano, G, Mari, D, Odetti, P, Monacelli, F, Antonelli Incalzi, R, Pluderi, A, Bellamoli, C, Terranova, L, Scarpini, E, D’Amico, F, Cavallini, Mc, Guerrini, G, Scotuzzi, Am, Chiarello, A, Pilotto, A, Tognini, S, Dell’Aquila, G, Toigo, G, Ceschia, G, Piccinini, M, Fabbo, A, Zoli, M, Forti, P, Wenter, C, Basile, G, Lasagni, A, Padovani, A, Rozzini, L, Cottino, M, Vitali, S, Tripi, G, Avanzi, S, Umidi, S, Moretti, D, Ruotolo, G, Boschi, F, Bonino, P, Marchionni, N, Fascendini, S, Noro, G, Turco, R, Ubezio, Mc, Serrati, C, Infante, M, Gentile, S, Pernigotti, Lm, Biagini, Ca, Canonico, E, Bonati, P, Gareri, P, Caffarra, P, Castagna, A, Ceretti, A, Castiglia, R, Gabelli, C, Lo Storto, M, Putzu, P, Di Santo, S, Rozzini, R, Zanetti, E, Trabucchi, M., Bo, M, Porrino, P, Di Santo, S, Mazzone, A, Cherubini, A, Mossello, E, Bianchetti, A, Musicco, M, Ferrari, A, Ferrara, N, Filippini, C, Trabucchi, M, Morandi, A, Bellelli, G, Bo, Mario, Porrino, Paola, Di Santo, Simona G., Mazzone, Andrea, Cherubini, Antonio, Mossello, Enrico, Bianchetti, Angelo, Musicco, Massimo, Ferrari, Alberto, Ferrara, Nicola, Filippini, Claudia, Trabucchi, Marco, Morandi, Alessandro, and Bellelli, Giuseppe

Subjects
Male, Aging, medicine.medical_specialty, 4AT test, Cognition, Delirium, Geriatric assessment, Aged, Aged, 80 and over, Catheters, Indwelling, Female, Humans, Logistic Models, Urinary Catheterization, Nursing Homes, Catheters, Hospitalized patients, medicine.medical_treatment, Logistic regression, behavioral disciplines and activities, Urinary catheterization, 03 medical and health sciences, 0302 clinical medicine, Informed consent, Internal medicine, mental disorders, medicine, 80 and over, Dementia, 030212 general & internal medicine, Coma, business.industry, Geriatrics and Gerontology, medicine.disease, Indwelling, medicine.symptom, Nursing homes, business, 030217 neurology & neurosurgery
Abstract

Backround: Use of indwelling urinary catheter (IUC) in older adults has negative consequences, including delirium. Aim: This analysis, from the "Delirium Day 2015", a nationwide multicenter prevalence study, aim to evaluate the association of IUC with delirium in hospitalized and Nursing Homes (NHs) patients. Methods: Patients underwent a comprehensive geriatric assessment, including the presence of IUC; inclusion criteria were age > 65 years, being Italian speaker and providing informed consent; exclusion criteria were coma, aphasia, end-of-life status. Delirium was assessed using the 4AT test (score >= 4: possible delirium; scores 1-3: possible cognitive impairment). Results: Among 1867 hospitalized patients (mean age 82.0 ± 7.5 years, 58% female), 539 (28.9%) had IUC, 429 (22.9%) delirium and 675 (36.1%) cognitive impairment. IUC was significantly associated with cognitive impairment (OR 1.60, 95% CI 1.19-2.16) and delirium (2.45, 95% CI 1.73-3.47), this latter being significant also in the subset of patients without dementia (OR 2.28, 95% CI 1.52-3.43). Inattention and impaired alertness were also independently associated with IUC. Among 1454 NHs residents (mean age 84.4 ± 7.4 years, 70.% female), 63 (4.3%) had IUC, 535 (36.8%) a 4AT score >= 4, and 653 (44.9%) a 4AT score 1-3. The multivariate logistic regression analysis did not show a significant association between 4AT test or its specific items with IUC, neither in the subset of patients without dementia. Discussion: We confirmed a significant association between IUC and delirium in hospitalized patients but not in NHs residents. Conclusion: Environmental and clinical factors of acute setting might contribute to IUC-associated delirium occurrence.

Published
2019
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6. The Italian dementia with Lewy bodies study group (DLB-SINdem): toward a standardization of clinical procedures and multicenter cohort studies design

Author

Bonanni, L, Cagnin, A., Agosta, F., Babiloni, C., Borroni, B., Bozzali, M., Bruni, A. C., Filippi, M., Galimberti, D., Monastero, R., Muscio, C., Parnetti, L., Perani, D., Serra, L., Silani, V., Tiraboschi, P., Padovani, A., On behalf of DLB SINdem study group, Null, Alberici, A., Alberoni, M., Amici, S., Appollonio, I., Arena, M. G., Arighi, A., Avanzi, S., Bagella, C. F., Baglio, F., Barocco, F., Belardinelli, N., Bonuccelli, U., Bottini, G., Bruno Bossio, R., Bruno, G., Buccomino, D., Cacchiò, G., Calabrese, E., Campanelli, A., Canevelli, M., Canu, E. D. G., Cappa, A., Capra, C., Carapelle, E., Caratozzolo, S., Carbone, G. F. S., Cattaruzza, T., Cerami, C., Cester, A., Cheldi, A., Cherchi, R., Chiari, A., Cirafisi, C., Colao, R., Confaloni, A., Conti, M. Z., Costa, A., Costa, B., Cotelli, M. S., Cova, I., Cravello, L., Cumbo, E., Cupidi, C., De Togni, L., Del Din, G., Del Re, M. L., Dentizzi, C., Di Lorenzo, F., Di Stefano, F., Dikova, N., Farina, E., Floris, G., Foti, A., Franceschi, M., Fumagalli, G. G., Gabelli, C., Ghidoni, E., Giannandrea, D., Giordana, M. T., Giorelli, M., Giubilei, F., Grimaldi, L., Grimaldi, R., Guglielmi, V., Lanari, A., Le Pira, F., Letteri, F., Levi Minzi, G. V., Lorusso, S., Ludovico, L., Luzzi, S., Maggiore, L., Magnani, G., Mancini, G., Manconi, F. M., Manfredi, L., Maniscalco, M., Marano, P., Marcon, M., Marcone, A., Marra, C., Martorana, A., Mascia, M. G., Mascia, V., Mauri, M., Mazzei, B., Meloni, M., Merlo, P., Messa, G., Milia, A., Monacelli, F., Montecalvo, G., Moschella, V., Mura, G., Nemni, R., Nobili, F., Notarelli, A., Di Giacomo, R., Onofrj, M., Paci, C., Padiglioni, C., Perini, M., Perotta, D., Perri, Formenti A., Perri, R., Piccininni, C., Piccoli, T., Pilia, G., Pilotto, A., Poli, S., Pomati, S., Pompanin, S., Pucci, E., Puccio, G., Quaranta, D., Rainero, I., Rea, G., Realmuto, S., Riva, M., Rizzetti, M. C., Rolma, G., Rozzini, L., Sacco, L., Saibene, F. L., Scarpini, E., Sensi, S., Seripa, D., Sinforiani, E., Sorbi, S., Sorrentino, Giuseppe, Spallazzi, M., Stracciari, A., Talarico, G., Tassinari, T., Thomas, A., Tiezzi, A., Tomassini, P. F., Trebbastoni, A., Tremolizzo, L., Tripi, G., Ursini, F., Vaianella, L., Valluzzi, F., Vezzadini, G., Vista, M., Volontè, M. A., Bonanni, L, Cagnin, A, Agosta, F, Babiloni, C, Borroni, B, Bozzali, M, Bruni, A, Filippi, M, Galimberti, D, Monastero, R, Muscio, C, Parnetti, L, Perani, D, Serra, L, Silani, V, Tiraboschi, P, Padovani, A, Alberici, A, Alberoni, M, Amici, S, Appollonio, I, Arena, M, Arighi, A, Avanzi, S, Bagella, C, Baglio, F, Barocco, F, Belardinelli, N, Bonuccelli, U, Bottini, G, Bruno Bossio, R, Bruno, G, Buccomino, D, Cacchiò, G, Calabrese, E, Campanelli, A, Canevelli, M, Canu, E, Cappa, A, Capra, C, Carapelle, E, Caratozzolo, S, Carbone, G, Cattaruzza, T, Cerami, C, Cester, A, Cheldi, A, Cherchi, R, Chiari, A, Cirafisi, C, Colao, R, Confaloni, A, Conti, M, Costa, A, Costa, B, Cotelli, M, Cova, I, Cravello, L, Cumbo, E, Cupidi, C, de Togni, L, Del Din, G, Del Re, M, Dentizzi, C, Di Lorenzo, F, Di Stefano, F, Dikova, N, Farina, E, Floris, G, Foti, A, Franceschi, M, Fumagalli, G, Gabelli, C, Ghidoni, E, Giannandrea, D, Giordana, M, Giorelli, M, Giubilei, F, Grimaldi, L, Grimaldi, R, Guglielmi, V, Lanari, A, Le Pira, F, Letteri, F, Levi Minzi, G, Lorusso, S, Ludovico, L, Luzzi, S, Maggiore, L, Magnani, G, Mancini, G, Manconi, F, Manfredi, L, Maniscalco, M, Marano, P, Marcon, M, Marcone, A, Marra, C, Martorana, A, Mascia, M, Mascia, V, Mauri, M, Mazzei, B, Meloni, M, Merlo, P, Messa, G, Milia, A, Monacelli, F, Montecalvo, G, Moschella, V, Mura, G, Nemni, R, Nobili, F, Notarelli, A, Di Giacomo, R, Onofrj, M, Paci, C, Padiglioni, C, Perini, M, Perotta, D, Perri, F, Perri, R, Piccininni, C, Piccoli, T, Pilia, G, Pilotto, A, Poli, S, Pomati, S, Pompanin, S, Pucci, E, Puccio, G, Quaranta, D, Rainero, I, Rea, G, Realmuto, S, Riva, M, Rizzetti, M, Rolma, G, Rozzini, L, Sacco, L, Saibene, F, Scarpini, E, Sensi, S, Seripa, D, Sinforiani, E, Sorbi, S, Sorrentino, G, Spallazzi, M, Stracciari, A, Talarico, G, Tassinari, T, Thomas, A, Tiezzi, A, Tomassini, P, Trebbastoni, A, Tremolizzo, L, Tripi, G, Ursini, F, Vaianella, L, Valluzzi, F, Vezzadini, G, Vista, M, Volontè, M, Bruni, Ac, DLB-SINdem study, Group, Bruni, AC, and Padovani, A - On behalf of DLB-SINdem study group

Subjects
Lewy Body Disease, medicine.medical_specialty, Pediatrics, Dementia with Lewy bodie, Dementia with Lewy bodies, Dermatology, Cohort Studies, Diagnosis, Differential, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Alzheimer Disease, Surveys and Questionnaires, mental disorders, Standardization of diagnostic procedures, Diagnosis, Survey, Disease Management, Humans, Italy, Research Design, 2708, Neurology (clinical), Psychiatry and Mental Health, medicine, Dementia, 030212 general & internal medicine, MED/01 - STATISTICA MEDICA, MED/26 - NEUROLOGIA, business.industry, Standardization of diagnostic procedure, General Medicine, medicine.disease, Settore MED/26 - NEUROLOGIA, Cohort, Differential, Physical therapy, Delirium, Alzheimer's disease, medicine.symptom, business, 030217 neurology & neurosurgery, Frontotemporal dementia, Cohort study
Abstract

Dementia with Lewy bodies (DLB) causes elevated outlays for the National Health Systems due to high institutionalization rate and patients' reduced quality of life and high mortality. Furthermore, DLB is often misdiagnosed as Alzheimer's disease. These data motivate harmonized multicenter longitudinal cohort studies to improve clinical management and therapy monitoring. The Italian DLB study group of the Italian Neurological Society for dementia (SINdem) developed and emailed a semi-structured questionnaire to 572 national dementia centers (from primary to tertiary) to prepare an Italian large longitudinal cohort. The questionnaire surveyed: (1) prevalence and incidence of DLB; (2) clinical assessment; (3) relevance and availability of diagnostic tools; (4) pharmacological management of cognitive, motor, and behavioural disturbances; (5) causes of hospitalization, with specific focus on delirium and its treatment. Overall, 135 centers (23.6 %) contributed to the survey. Overall, 5624 patients with DLB are currently followed by the 135 centers in a year (2042 of them are new patients). The percentage of DLB patients was lower (27 ± 8 %) than that of Alzheimer's disease and frontotemporal dementia (56 ± 27 %) patients. The majority of the centers (91 %) considered the clinical and neuropsychological assessments as the most relevant procedure for a DLB diagnosis. Nonetheless, most of the centers has availability of magnetic resonance imaging (MRI; 95 %), electroencephalography (EEG; 93 %), and FP-CIT single photon emission-computerized tomography (SPECT; 75 %) scan for clinical applications. It will be, therefore, possible to recruit a large harmonized Italian cohort of DLB patients for future cross-sectional and longitudinal multicenter studies.

Published
2017

12. Prevalence and Correlates of Behavioral Disorders in Old Age Subjects with Cognitive Impairment: Results from the ReGAl Project

Author

Boccardi, Virginia, Conestabile Della Staffa, Manuela, Baroni, Marta, Ercolani, Sara, Croce, Michele Francesco, Ruggiero, Carmelinda, Mecocci, Patrizia, Gabelli, C, Codemo, A, Marinelli, K, Capurso, A, Cucinotta, D, Reggiani, A, Ellena, L, Zanetti, O, Putzu, P, Del Prete, M, Spaccamento, S, Abate, G, Di Iorio, A, Cester, A, Formilan, M, Busonera, F, Anzivino, F, Masotti, G, Cavallini, C, Mossello, E, Odetti, P, Cataldi, Ag, Estraneo, A, Sica, G, Renna, S, Nicita-Mauro, V, Basile, G, Salvioli, G, Mussi, C, Ascari, S, Casale, R, Frazzitta, G, Scognamiglio, M, Di Palma, A, Rengo, F, Canonico, V, Fortunato, F, Enzi, G, Giordano, M, Vitrano Catania, T, Ferrari, E, Cuzzoni, G, Del Re ML, Guizzardi, G, Biagini, C, Bavazzano, A, Ferrari, A, Dallari, A, Carbonin, P, Bernabei, R, Silveri, Mc, Bartorelli, L, Gandolfi, B, Cerqua, R, Pilotto, A, Cascavilla, L, Chiaranti, A, Marinelli, M, Tripi, G, Gallucci, M, Marchetti, C, Masiello, V, Sacco, D, and Ricci, G.

Subjects
Male, Behavioral disturbances, cognitive impairment, dementia, old age, Settore M-PSI/02 - PSICOBIOLOGIA E PSICOLOGIA FISIOLOGICA, Behavioral Symptoms, Comorbidity, Severity of Illness Index, Sex Factors, Prevalence, Humans, Cognitive Dysfunction, Longitudinal Studies, Aged, Psychotropic Drugs, Age Factors, Clinical Psychology, Logistic Models, Socioeconomic Factors, Psychiatry and Mental Health, Female, Geriatrics and Gerontology, Factor Analysis, Statistical
Abstract

Presence of behavioral and psychological symptoms of dementia (BPSD) is very common in subjects with cognitive impairment, representing an important determinant of disease progression, institutionalization, and worse prognosis. Knowledge of the prevalence and correlates of BPSD in community-living old subjects with cognitive impairment is limited so far, but it is essential for establishing specifically tailored care and cure in such a vulnerable population.With this study, we aimed at investigating, in a large sample of old age subjects with cognitive impairment, BPSD prevalence and correlates including the main demographic, clinical, and socio-environmental characteristics.Data were gathered from the ReGAl project (Rete Geriatrica Alzheimer; Geriatric Network on Alzheimer's disease), a large longitudinal Italian multicentric clinical-based study, promoted by the Italian Society of Gerontology and Geriatrics (SIGG).We evaluated data from 4,157 old-age subjects affected by mild cognitive impairment (MCI) (541; 13%) or dementia (3616; 87%). 85.2% of all the population presented with at least one BPSD. Using a factor analysis, we identified four factors of BPSD: psychotic, affective, maniac, and impulse control behaviors. Logistic regression analyses revealed that among the main demographic, clinical, and socio-environmental aspects considered, only comorbidity was associated with all factors, independently of multiple covariates.Identification of BPSD is crucial in everyday clinical practice and necessary to develop specific interventions and to define appropriate outcomes in their management. BPSD occur in a complex psychopathological context, influenced by several demographic and environmental factors that must be taken into account for a correct diagnosis and treatment.

Published
2017

13. Clinical Features Associated with Delirium Motor Subtypes in Older Inpatients: Results of a Multicenter Study

Author

Morandi, A, Di Santo, S, Cherubini, A, Mossello, E, Meagher, D, Mazzone, A, Bianchetti, A, Ferrara, N, Ferrari, A, Musicco, M, Trabucchi, M, Bellelli, G, Boffelli, S, Di Stefano, F, De Filippi, F, Guerini, F, Bertoletti, E, March, A, Margiotta, A, Mecocci, P, Addesi, D, Fanto, F, Isaia, G, Dijik, B, Porrino, P, Cotroneo, A, Galli, G, Bruni, A, Bernardini, B, Corsini, C, Cagnin, A, Zurlo, A, Barbagallo, G, Lunardelli, M, Martini, E, Battaglia, G, Latella, R, Petritola, D, Sinforiani, E, Cester, A, Formilan, M, Carbone, P, Appollonio, I, Cereda, D, Tremolizzo, L, Bottacchi, E, Lucchetti, L, Mariani, C, Rapazzini, P, Romanelli, G, Marengoni, A, Zuliani, G, Bianchi, L, Suardi, T, Muti, E, Bottura, R, Sgro, G, Mandas, A, Serchisu, L, Crippa, P, Ivaldi, C, Ungar, A, Villani, D, Raimondi, C, Mussi, C, Provenzano, G, Mari, D, Odetti, P, Monacelli, F, Incalzi, R, Pluderi, A, Bellamoli, C, Terranova, L, Scarpini, E, D'Amico, F, Cavallini, M, Guerrini, G, Scotuzzi, A, Chiarello, A, Pilotto, A, Tognini, S, Dell'Aquila, G, Toigo, G, Ceschia, G, Piccinini, M, Fabbo, A, Zoli, M, Forti, P, Wenter, C, Basile, G, Lasagni, A, Padovani, A, Rozzini, L, Cottino, M, Vitali, S, Tripi, G, Avanzi, S, Umidi, S, Moretti, D, Ruotolo, G, Boschi, F, Bonino, P, Marchionni, N, Fascendini, S, Noro, G, Turco, R, Ubezio, M, Serrati, C, Infante, M, Gentile, S, Pernigotti, L, Biagini, C, Canonico, E, Bonati, P, Gareri, P, Caffarra, P, Ceretti, A, Castiglia, R, Gabelli, C, Storto, M, Putzu, P, Rozzini, R, Zanetti, E, Bo, M, Morandi, A, Di Santo, S, Cherubini, A, Mossello, E, Meagher, D, Mazzone, A, Bianchetti, A, Ferrara, N, Ferrari, A, Musicco, M, Trabucchi, M, Bellelli, G, Boffelli, S, Di Stefano, F, De Filippi, F, Guerini, F, Bertoletti, E, March, A, Margiotta, A, Mecocci, P, Addesi, D, Fanto, F, Isaia, G, Dijik, B, Porrino, P, Cotroneo, A, Galli, G, Bruni, A, Bernardini, B, Corsini, C, Cagnin, A, Zurlo, A, Barbagallo, G, Lunardelli, M, Martini, E, Battaglia, G, Latella, R, Petritola, D, Sinforiani, E, Cester, A, Formilan, M, Carbone, P, Appollonio, I, Cereda, D, Tremolizzo, L, Bottacchi, E, Lucchetti, L, Mariani, C, Rapazzini, P, Romanelli, G, Marengoni, A, Zuliani, G, Bianchi, L, Suardi, T, Muti, E, Bottura, R, Sgro, G, Mandas, A, Serchisu, L, Crippa, P, Ivaldi, C, Ungar, A, Villani, D, Raimondi, C, Mussi, C, Provenzano, G, Mari, D, Odetti, P, Monacelli, F, Incalzi, R, Pluderi, A, Bellamoli, C, Terranova, L, Scarpini, E, D'Amico, F, Cavallini, M, Guerrini, G, Scotuzzi, A, Chiarello, A, Pilotto, A, Tognini, S, Dell'Aquila, G, Toigo, G, Ceschia, G, Piccinini, M, Fabbo, A, Zoli, M, Forti, P, Wenter, C, Basile, G, Lasagni, A, Padovani, A, Rozzini, L, Cottino, M, Vitali, S, Tripi, G, Avanzi, S, Umidi, S, Moretti, D, Ruotolo, G, Boschi, F, Bonino, P, Marchionni, N, Fascendini, S, Noro, G, Turco, R, Ubezio, M, Serrati, C, Infante, M, Gentile, S, Pernigotti, L, Biagini, C, Canonico, E, Bonati, P, Gareri, P, Caffarra, P, Ceretti, A, Castiglia, R, Gabelli, C, Storto, M, Putzu, P, Rozzini, R, Zanetti, E, and Bo, M

Abstract

Objective To date motor subtypes of delirium have been evaluated in single-center studies with a limited examination of the relationship between predisposing factors and motor profile of delirium. We sought to report the prevalence and clinical profile of subtypes of delirium in a multicenter study. Methods This is a point prevalence study nested in the “Delirium Day 2015”, which included 108 acute and 12 rehabilitation wards in Italy. Delirium was detected using the 4-AT and motor subtypes were measured with the Delirium Motor Subtype Scale (DMSS). A multinomial logistic regression was used to determine the factors associated with delirium subtypes. Results Of 429 patients with delirium, the DMSS was completed in 275 (64%), classifying 21.5% of the patients with hyperactive delirium, 38.5% with hypoactive, 27.3% with mixed and 12.7% with the non-motor subtype. The 4-AT score was higher in the hyperactive subtype, similar in the hypoactive, mixed subtypes, while it was lowest in the non-motor subtype. Dementia was associated with all three delirium motor subtypes (hyperactive, OR 3.3, 95% CI: 1.2-8.7; hypoactive, OR 2.8, 95% CI: 1.2-6.5; mixed OR 2.6, 95% CI: 1.1-6.2). Atypical antipsychotics were associated with hypoactive delirium (OR 0.23, 95% CI: 0.1-0.7), while intravenous lines were associated with mixed delirium (OR 2.9, 95% CI: 1.2-6.9). Conclusions The study shows that hypoactive delirium is the most common subtype among hospitalized older patients. Specific clinical features were associated with different delirium subtypes. The use of standardized instruments can help to characterize the phenomenology of different motor subtypes of delirium.

Published
2017

15. Effectiveness of switching to the rivastigmine transdermal patch from oral cholinesterase inhibitors: a naturalistic prospective study in Alzheimer's disease

Author

Cagnin, Annachiara, Cester, A, Costa, B, Ermani, Mario, Gabelli, C, Gambina, G, and SWITCH study working Group

Subjects
Male, medicine.medical_specialty, Neurology, Transdermal patch, Administration, Oral, Transdermal Patch, Rivastigmine, Dermatology, Neuropsychological Tests, Administration, Cutaneous, Alzheimer Disease, Humans, Medicine, Adverse effect, Donepezil, Prospective cohort study, Aged, Aged, 80 and over, business.industry, General Medicine, Psychiatry and Mental health, Treatment Outcome, Tolerability, Tolerability Study, Anesthesia, Female, Cholinesterase Inhibitors, Neurology (clinical), business, medicine.drug
Abstract

Oral donepezil and rivastigmine are two commonly used cholinesterase inhibitors (ChEIs) used in Alzheimer's disease (AD). The rivastigmine transdermal patch formulation has high tolerability profile, allowing patients to achieve optimal therapeutic doses and providing potential advantages over oral ChEIs. This is a 6-month, multicentre, observational efficacy and tolerability study of switching from oral ChEIs to rivastigmine patch in AD patients who failed to show benefit from previous treatment. The reasons of the switch were: (1) lack/loss of benefit from previous oral ChEI treatment; (2) tolerability problems. The primary outcome was cognitive changes measured with the mini-mental state examination (MMSE) test. Secondary outcomes were modifications of functional independence and behavioral disturbances and occurrence of adverse events (AEs) after switching. 174 patients, over 180 patients screened, entered the study (lack/loss of efficacy: 57 %, tolerability problems: 33 %, both reasons: 10 %). 6 months after switching 56 % of patients stabilized or increased the MMSE score respect to baseline. The only predictor of this outcome was the response at 3 months. In the group with lack/loss of response to oral ChEI, the decline of the MMSE score changed from -3.4 ± 2.5 points in the 6 months before switching to -0.5 ± 3.2 in the 6 months after the switch (p < 0.001). There were no significant changes in the IADL or NPI scores. Drug discontinuation rate was 20 %, due to AEs (18 %) and lack of compliance (2 %). Switching from an unsuccessful oral ChEI therapy to rivastigmine patch is effective and safe in more than half of the switched patients after a 6-month period.

Published
2015

16. PARAOXONASE 1 GENE POLYMORPHISMS IN ALZHEIMER DISEASE AND VASCULAR DEMENTIA

Author

Cagnin, A, Lunardelli, V, Moretti, Rita, Briani, C, Gabelli, C, Terrazzino, S, Miccichè, F, Stecca, A, Passarotto, M, Ricchieri, Gl, Pizzolato, G, Leon, A, Battistin, L., Cagnin, A, Lunardelli, V, Moretti, Rita, Briani, C, Gabelli, C, Terrazzino, S, Miccichè, F, Stecca, A, Passarotto, M, Ricchieri, Gl, Pizzolato, G, Leon, A, and Battistin, L.

Published
2006

17. La legionellosi come problema emergente di Sanità Pubblica

Author

Borella P., Berri A., Boccia S., Bruscolini F., Calcagnile G., Carducci A. Casini B., Clerici M., Delia S., Gabelli C., Laganà P., Marchesi I., Molinari A., Montagna M. T., Pianetti A., Pignato S., Romano Spica V., Stancanelli G., Triassi M., Villa G., Zotti C., LEONI, ERICA, Borella P., Berri A., Boccia S., Bruscolini F., Calcagnile G., Carducci A. Casini B., Clerici M., Delia S., Gabelli C., Laganà P., Leoni E., Marchesi I., Molinari A., Montagna M.T., Pianetti A., Pignato S., Romano-Spica V., Stancanelli G., Triassi M., Villa G., and Zotti C.

Published
2005

18. Hearing loss and cognitive decline in older adults: Questions and answers

Author

Bernabei, R, Bonuccelli, U, Maggi, S, Marengoni, Alessandra, Martini, A, Memo, Maurizio, Pecorelli, Sergio, Peracino, A, Quaranta, N, Stella, R, Lin, F, Berrettini, S, Bertolotti, A, Canale, A, Castiglione, A, Cristofari, E, Cuda, D, De Caria, A, Folco, E, Gabelli, C, Genovese, E, Ghidoni, E, Leone, Ca, Mauri, Marta Rosa Maria, Padovani, Alessandro, Paludetti, G, Pirodda, A, Postiglione, A, REDAELLI DE ZINIS, Luca Oscar, Tortelli, R., Roberto Bernabei, Ubaldo Bonuccelli, Stefania Maggi, Alessandra Marengoni, Alessandro Martini, Maurizio Memo, Sergio Pecorelli, Andrea P. Peracino, Nicola Quaranta, Roberto Stella, Frank R. Lin, For the participants in the Workshop on Hearing Loss and Cognitive Decline in Older Adults [.., Antonio Pirodda, and ]

Subjects
Questions and answers, Gerontology, Age-related hearing loss, Cognitive decline, Dementia, Interdisciplinary collaboration, Sensory therapy, Animals, Cognition, Cognition Disorders, Hearing Loss, Humans, Aging, Geriatrics and Gerontology, Medicine (all), Hearing loss, media_common.quotation_subject, MEDLINE, Presentation, Cognition Disorder, otorhinolaryngologic diseases, Medicine, Association (psychology), Hearing Lo, cognitive impairment, media_common, business.industry, Animal, Settore MED/09 - MEDICINA INTERNA, medicine.disease, Age-related hearing lo, Settore MED/32 - AUDIOLOGIA, Settore MED/31 - OTORINOLARINGOIATRIA, medicine.symptom, business, Human
Abstract

The association between hearing impairment, the diagnosis of dementia, and the role of sensory therapy has been proposed for some time, but further research is needed. Current understanding of this association requires the commitment of those experts who can integrate experience and research from several fields to be able to understand the link from hearing to dementia. A workshop whose panelists included experts from many areas, ranging from ear, nose and throat (ENT) to dementia's specialists, was promoted and organized by the Giovanni Lorenzini Medical Science Foundation (Milan, Italy; Houston, TX, USA) to increase the awareness of the relationship between hearing loss and dementia, and included questions and comments following a presentation from the clinical researcher, Frank Lin, who has been evaluating the relationship between hearing loss and cognitive decline since 2009.

Published
2014

19. Screening of the PFN1 gene in sporadic amyotrophic lateral sclerosis and in frontotemporal dementia

Author

Tiloca, C, Ticozzi, N, Pensato, V, Corrado, L, Del Bo, R, Bertolin, C, Fenoglio, C, Gagliardi, S, Calini, D, Lauria, G, Castellotti, B, Bagarotti, A, Corti, S, Galimberti, D, Cagnin, A, Gabelli, C, Ranieri, M, Ceroni, M, Siciliano, Gabriele, Mazzini, L, Cereda, C, Scarpini, E, Sorarù, G, Comi, Gp, D'Alfonso, S, Gellera, C, Ratti, A, Landers, Je, Silani, V, and Slagen, Consortium

Subjects
Genetic Markers, Male, Aging, Pathology, medicine.medical_specialty, Comorbidity, medicine.disease_cause, Filamentous actin, Polymorphism, Single Nucleotide, Article, Profilins, Polymorphism (computer science), Risk Factors, medicine, Prevalence, Humans, Amyotrophic lateral sclerosis, Gene, Genetics, Mutation, biology, General Neuroscience, Amyotrophic Lateral Sclerosis, Middle Aged, medicine.disease, Profilin, Italy, Frontotemporal Dementia, biology.protein, Mutation testing, Female, Neurology (clinical), Geriatrics and Gerontology, Developmental Biology, Frontotemporal dementia
Abstract

Mutations in the profilin 1 (PFN1) gene, encoding a protein regulating filamentous actin growth through its binding to monomeric G-actin, have been recently identified in familial amyotrophic lateral sclerosis (ALS). Functional studies performed on ALS-associated PFN1 mutants demonstrated aggregation propensity, alterations in growth cone, and cytoskeletal dynamics. Previous screening of PFN1 gene in sporadic ALS (SALS) cases led to the identification of the p.E117G mutation, which is likely to represent a less pathogenic variant according to both frequency data in control subjects and cases, and functional experiments. To determine the effective contribution of PFN1 mutations in SALS, we analyzed a large cohort of 1168 Italian SALS patients and also included 203 frontotemporal dementia (FTD) cases because of the great overlap between these 2 neurodegenerative diseases. We detected the p.E117G variant in 1 SALS patient and the novel synonymous change p.G15G in another patient, but none in a panel of 1512 control subjects. Our results suggest that PFN1 mutations in sporadic ALS and in FTD are rare, at least in the Italian population.

Published
2012

21. Evidence for sub-haplogroup h5 of mitochondrial DNA as a risk factor for late onset Alzheimer's disease

Author

Santoro, A., Balbi, V., Balducci, E., Pirazzini, C., Rosini, F., Tavano, F., Achilli, A., Siviero, P., Minicuci, N., Bellavista, E., Mishto, M., Salvioli, S., Marchegiani, F., Cardelli, M., Olivieri, F., Nacmias, Benedetta, Chiamenti, A. M., Benussi, L., Ghidoni, R., Rose, G., Gabelli, C., Binetti, G., Sorbi, Sandro, Crepaldi, G., Passarino, G., Torroni, A., and Franceschi, C.

Subjects
apolipoprotein E4mitochondrial DNAribosome RNAtransfer RNAmitochondrial DNA
Published
2010

22. Influence of comorbidity and cognitive status on instrumental activities of daily living in amnestic mild cognitive impairment: results from the ReGAl project

Author

Mariani, E., Monastero, R., Ercolani, S., Rinaldi, P., Mangialasche, F., Costanzi, E., Vitale, D. F., Senin, U., Mecocci, P, Gabelli, C., Codemo, A., Marinelli, K., Capurso, A., Cucinotta, D., Reggiani, A., Ellena, L., Zanetti, O., Putzu, P., Del Prete, M., Spaccamento, S., Abate, G., Di Iorio, A., Cester, A., Formilan, M., Busonera, F., Anzivino, F., Masotti, G., Cavallini, C., Mossello, E., Odetti, P., Cataldi, A. G., Pippi, M., Estraneo, A., Sica, G., Renna, S., NICITA MAURO, Vittorio, Basile, Giorgio, Salvioli, G., Mussi, C., Ascari, S., Casale, R., Frazzitta, G., Scognamiglio, M., Di Palma, A., Rengo, F., Canonico, V., Fortunato, F., Enzi, G., Giordano, M., Vitrano Catania, T., Ferrari, E., Cuzzoni, G., Del Re, M. L., Guizzardi, G., Biagini, C., Bavazzano, A., Ferrari, A., Dallari, A., Carbonin, P., Bernabei, R., Silveri, M. C., Bartorelli, L., Gandolfi, B., Cerqua, R., Pilotto, A., Cascavilla, L., Chiaranti, A., Marinelli, M., Tripi, G., Gallucci, M., Marchetti, C., Masiello, V., Sacco, D., Ricci, G., MARIANI E, MONASTERO R, ERCOLANI S, RINALDI P, MANGIALASCHE F, COSTANZI E, VITALE DF, SENIN U, and MECOCCI P

Subjects
Gerontology, Male, medicine.medical_specialty, Activities of daily living, Settore MED/25 - PSCHIATRIA, Comorbidity, Neuropsychological Tests, behavioral disciplines and activities, Disability Evaluation, Mental Processes, Rating scale, Executive function, mental disorders, medicine, 80 and over, Humans, Effects of sleep deprivation on cognitive performance, Cognitive performance, Aged, Geriatrics, Cognitive evaluation theory, Aged, 80 and over, Depressive Disorder, Cognitive disorder, Mild cognitive impairment, Cognition, medicine.disease, Activities of Daily Living, Amnesia, Female, Geriatrics and Gerontology, Psychiatry and Mental Health, Settore MED/26 - Neurologia, activities of the day living, Psychology, human activities
Abstract

Objectives To investigate whether amnestic mild cognitive impairment (aMCI) is characterised by restriction in instrumental activities of daily living (IADL). Further, to examine the role of comorbidity and cognitive performance on IADL changes in aMCI subjects. Methods The study included 132 subjects with aMCI and 249 subjects with no cognitive impairment (NCI), consecutively enrolled as outpatients in a multicentric Italian clinical-based study, the ReGAl Project. All subjects underwent a comprehensive evaluation including clinical examination, laboratory screening, neuroimaging and cognitive and behavioral assessments. Functional status was evaluated by the Lawton's Instrumental Activities of Daily Living (IADL) scale. Comorbidity was evaluated by the Cumulative Illness Rating Scale (CIRS). Cognitive evaluation included tests assessing episodic memory, language, attention/executive functioning and praxis, as well as the the Mini-Mental State Examination (MMSE) as a measure of global cogniton. Results Subjects with aMCI had higher IADL changes than NCI. Among IADL items, aMCI subjects showed a significant impairment in shopping, taking drugs, and handling economy; however also NCI had minor IADL changes regarding cooking, washing and cleaning. IADL restriction in aMCI subjects was significantly associated with cognitive performance, mainly related to executive functioning, but not with comorbidity. On the contrary, in NCI sensory impairment accounts for slight IADL changes. Conclusion In aMCI subjects a mild degree of cognitive deterioration has a stronger impact on IADL than somatic comorbidity. Current diagnostic criteria for MCI should include a mild impairment in IADL. Copyright © 2007 John Wiley & Sons, Ltd.

Published
2008

23. Le legionellosi come problema emergente di Sanità Pubblica: attività del Gruppo di lavoro della SItI

Author

Borella, P., Boccia, S., Bruscolini, Francesca, Calcagnile, G., Carducci, A., Casini, B., Clerici, M., Delia, S., Gabelli, C., Lagana, P., Leoni, E., Marchesi, I., Masa, E., Molinari, A., Momtagna, M. T., Navarra, A., Pianetti, Anna, Pagnato, S., ROMANO SPICA, V., Stancanelli, G., Triassi, M., Villa, G., and Zotti, C.

Subjects
Legionella, Legionellosi, Sistemi di disinfezione, Contaminazione idrica
Published
2005

28. LDL-apheresis: Comparison of methods

Author

De Silvestro, G., Marson, P., Gabelli, C., Sartore, G., and Ongaro, G.

Subjects
Comparison, LDL-apheresis, Selective and unselective methods
Published
1998

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