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22 results on '"Gaafar, Khadiga"'

1. Guidelines for the establishment and functioning of Animal Ethics Commitees (Institutional Animal Care and Use Committees) in Africa

Author

Mohr, Bert J, primary, Souilem, Ouajdi, additional, Fahmy, Sohair R, additional, Fakoya, Francis, additional, Gaafar, Khadiga, additional, Kantiyok, Josiah T, additional, Khammar, Farida, additional, Mbarek, Sarrah, additional, Mugisha, Lawrence, additional, Sleem, Hany, additional, Toma, Alemayehu, additional, van Rooyen, Maricél, additional, Zakumumpa, Henry, additional, and Lewis, David I, additional

Published
2023
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2. Sustainable education and training in laboratory animal science and ethics in low- and middle-income countries in Africa – challenges, successes, and the way forward

Author

Mohr, Bert J, Souilem, Ouajdi, Abdussamad, Abdussamad M, Benmouloud, Abelouafi, Bugnon, Phillippe, Chipangura, John K, Fahmy, Sohair R, Fourie, Tamsyn, Gaafar, Khadiga, Jillani, Ngalla E, Kantyok, Josiah T, Martin, Louise F, Mokopasetso, Mokganedi, Mugisha, Lawrence, Nyachieo, Atunga, Lewis, David I, and University of Zurich

Subjects
General Veterinary, 570 Life sciences, biology, 590 Animals (Zoology), 610 Medicine & health, 10239 Institute of Laboratory Animal Science, Animal Science and Zoology
Abstract

Despite the recognised need for education and training in laboratory animal science (LAS) and ethics in Africa, access to such opportunities has historically been limited. To address this, the Pan-African Network for Laboratory Animal Science and Ethics (PAN-LASE) was established to pioneer a support network for the development of education and training in LAS and ethics across the African continent. In the 4.5 years since the establishment of PAN-LASE, 3635 individuals from 28 African countries have participated in our educational activities. Returning to their home institutions, they have both established and strengthened institutional and regional hubs of knowledge and competence across the continent. Additionally, PAN-LASE supported the development of guidelines for establishment of institutional Animal Ethics Committees, a critical step in the implementation of ethical review processes across the continent, and in enhancing animal welfare and scientific research standards. Key challenges and opportunities for PAN-LASE going forward include the formalisation of the network; the sustainability of education and training programmes; implementation of effective hub-and-spoke models of educational provision; strengthening governance frameworks at institutional, national and regional levels; and the availability of Africa-centric open access educational resources. Our activities are enhancing animal welfare and the quality of animal research undertaken across Africa, enabling African researchers to undertake world-leading research to offer solutions to the challenges facing the continent. The challenges, successes and the lessons learnt from PAN-LASE’s journey are applicable to other low- and middle-income countries across the world seeking to enhance animal welfare, research ethics and ethical review in their own country or region.

Published
2022
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4. Guidelines for the establishment and functioning of Animal Ethics Commitees (Institutional Animal Care and Use Committees) in Africa.

Author

Mohr, Bert J, Souilem, Ouajdi, Fahmy, Sohair R, Fakoya, Francis, Gaafar, Khadiga, Kantiyok, Josiah T, Khammar, Farida, Mbarek, Sarrah, Mugisha, Lawrence, Sleem, Hany, Toma, Alemayehu, van Rooyen, Maricél, Zakumumpa, Henry, and Lewis, David I

Subjects
ANIMAL welfare, INSTITUTIONAL care, ETHICS, ETHICS committees, QUALITY assurance
Abstract

Copyright of Laboratory Animals is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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6. Sustainable education and training in laboratory animal science and ethics in low- and middle-income countries in Africa – challenges, successes, and the way forward.

Author

Mohr, Bert J, Souilem, Ouajdi, Abdussamad, Abdussamad M, Benmouloud, Abelouafi, Bugnon, Phillippe, Chipangura, John K, Fahmy, Sohair R, Fourie, Tamsyn, Gaafar, Khadiga, Jillani, Ngalla E, Kantyok, Josiah T, Martin, Louise F, Mokopasetso, Mokganedi, Mugisha, Lawrence, Nyachieo, Atunga, and Lewis, David I

Subjects
ANIMAL training, ANIMAL science, LABORATORY animals, MIDDLE-income countries, LABORATORIES, RESEARCH ethics, ANIMAL welfare
Abstract

Copyright of Laboratory Animals is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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9. Assessment of the most common CYP21A2 point mutations in a cohort of congenital adrenal hyperplasia patients from Egypt

Author

Essawi, Mona, primary, Mazen, Inas, additional, Fawaz, Lubna, additional, Hassan, Heba, additional, ElBagoury, Nagham, additional, Peter, Michael, additional, Gaafar, Khadiga, additional, Amer, Mahmoud, additional, Nabil, Wajeet, additional, Hohmann, Gisela, additional, Soliman, Hala, additional, and Sippell, Wolfgang, additional

Published
2020
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20. Effect of Chloroquine on Glucose Metabolism.

Author

Gaafar, Khadiga M., Khedr, Mona I., Bashandy, Samir A., Sharaf, Olaa A., and El-Zayat, Salwa R.

Subjects
CHLOROQUINE, GLUCOSE, METABOLISM
Abstract

The long- and short-term effects of chloroquine (CAS 54-05-7) on glucose metabolism in rats were assessed. The long-term chronic chloroquine administration (5 and 10 mg/kg. b.w. 6 days a week for 6 months) caused a decrease in serum glucose, insulin, calcium potassium and protein levels, while the glucagon level increased. The short-term acute effect of choloroquine administration (10 mg/kg b.w. 6 days for one week) caused an improvement in glucose tolerance as shown by the decrease in glucose and insulin curves after an oral glucose tolerance test. This was accompanied by an increase in insulin activity, corrected insulin response, and glucose tolerance parameter and a decrease in glucose and insulin areas. Lactate dehydrogenase and glucose-6-phosphate dehydrogenase activities were increased, too, indicating an increase which provides the needed energy for overcoming the injurious effect of chloroquine. [ABSTRACT FROM AUTHOR]

Published
2002

21. THE PROTECTIVE POTENCY OF VITAMINS E AND C IN METHANOL-INDUCED OXIDATIVE STRESS AND RETINOTOXICITY

Author

El-Sayed, Nagla K., Gaafar, Khadiga M., El-Ansary, Afaf K., and Osman, Amal I.

Abstract

The protective effects of vitamins E and C against methanol-induced free radical production with its subsequent tissue injury in liver and retina of male albino rats were assessed. The rats were divided into four groups: (1) control, (2) antioxidant (Ao) control group receiving 5 mg of each vitamin, E and C, (3) daily ip-injected methanol (2 mLkg b.wt.) group, killed after three and six doses, and (4) Aomethanol group administered the vitamins 3 weeks prior to and along with methanol injection and killed as the latter group [Sharpe et al. Methanol Optic Neuropathy: A Histopathological Study. Neurology 1982, 32(10), 1093–1100].Methyl alcohol drastically altered the Ao defense system and energy status of rat liver, where highly significant depletion of glutathione levels and inhibition of superoxide dismutase activity, concurrent with significant increase in thiobarbituric acid reactive substances indicating marked elevation in lipid peroxidation. These effects were reversed when the vitamins were administered denoting their role in promoting the Ao defense system. Furthermore, they also increased the methanol-induced depletion in adenylate energy charge, phosphate potential, and ATP values. The amelioration in the energy status as a result of vitamins E and C supplementation suggests that their role as Aos is effective in relieving the impaired oxidative phosphorylation in order to increase the energy demand under physiologically stressful conditions.Histopathological and ultrastructural results of rat retina confirmed the protective effect of Ao vitamins. As compared to the methanol-intoxicated group, the protected group showed preservation of the membranous structures of the retinal cells, especially mitochondria that assumed their normal shape. This may be attributed to the inhibition of free radical production and lipid peroxidation and subsequently minimum degree of tissue damage. Amelioration of mitochondrial structure reflected the improvement of impaired oxidative phosphorylation of intoxicated animals with an approximately normal level of energy demand. This suggests that Ao vitamins may alter the retinotoxic effects of methanol by promoting the internal Ao defense system and preserving the energy status of the animal.

Published
2002
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22. Effect of chloroquine on glucose metabolism.

Author

Gaafar KM, Khedr MI, Bashandy SA, Sharaf OA, and el-Zayat SR

Subjects
Algorithms, Animals, Antimalarials administration & dosage, Blood Glucose metabolism, Chloroquine administration & dosage, Female, Glucose Tolerance Test, Glucosephosphate Dehydrogenase blood, Half-Life, Insulin blood, L-Lactate Dehydrogenase blood, Rats, Time Factors, Antimalarials pharmacology, Chloroquine pharmacology, Glucose metabolism
Abstract

The long- and short-term effects of chloroquine (CAS 54-05-7) on glucose metabolism in rats were assessed. The long-term chronic chloroquine administration (5 and 10 mg/kg b.w. 6 days a week for 6 months) caused a decrease in serum glucose, insulin, calcium, potassium and protein levels, while the glucagon level increased. The short-term acute effect of chloroquine administration (10 mg/kg b.w. 6 days for one week) caused an improvement in glucose tolerance as shown by the decrease in glucose and insulin curves after an oral glucose tolerance test. This was accompanied by an increase in insulin activity, corrected insulin response, and glucose tolerance parameter and a decrease in glucose and insulin areas. Lactate dehydrogenase and glucose-6-phosphate dehydrogenase activities were increased, too, indicating an increase which provides the needed energy for overcoming the injurious effect of chloroquine.

Published
2002
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