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179 results on '"GUO Dongqing"'

20. Effectiveness of Xiaoyao capsule (逍遥丸) on sleep disorders and mood disturbance in patients in recovery from coronavirus disease 2019: a randomized controlled trial

Author

YANG, Cunqing, LIAN, Fengmei, YANG, Guiping, HUANG, Yufeng, ZHANG, Shuangbin, WANG, Jianghua, ZHOU, Jing, GUO, Dongqing, SHEN, Chuanyun, YE, Tiansong, FU, Aojie, LI, Xiaoli, CHEN, Le, ZHANG, Huifeng, TU, Qiyin, WANG, Ying, YANG, Wenzhe, TONG, Xiaolin, and BA, Yuanming

Subjects
Original Article
Abstract

OBJECTIVE: To study the efficacy of Xiaoyao capsule (逍遥丸) in improving the clinical symptoms of sleep and mood disorders during recovery from coronavirus disease 2019 (COVID-19). METHODS: The study cohort comprised 200 patients with sleep and mood disorders during recovery from COVID-19. Patients were randomized into the control group and the experimental group in a 1:1 ratio by blocked randomization. The patients received either Xiaoyao capsule (experimental group) or a placebo Xiaoyao capsule (control group) for 2 weeks. The improvements in the Traditional Chinese Medicine (TCM) syndrome scales, total effective rates, and disappearance rates of irritability, anxiety, and poor sleep were compared between the two groups. RESULTS: The TCM syndrome pattern scales, total effective rates, and disappearance rates of irritability, anxiety, and poor sleep did not significantly differ between the experimental group versus the control group in the full analysis set and the per protocol set after 1 and 2 weeks of treatment (P > 0.05). CONCLUSIONS: Xiaoyao capsule do not significantly improve the clinical symptoms of sleep and mood disorders in patients in recovery from COVID-19.

Published
2023

21. In vivo monitoring of glutathione in a live rat brain based on the ratiometric signal output of 2D Cu-TCPP(Fe) nanosheets.

Author

Zhao, Fan, Tang, Xuan, and Guo, Dongqing

Subjects
NANOSTRUCTURED materials, GLUTATHIONE, CEREBRAL ischemia, RATS
Abstract

Herein, a novel ratiometric electrochemical platform was developed for in vivo analysis of GSH based on the dual signal output of 2D Cu-TCPP(Fe) nanosheets. Our method with high selectivity and high accuracy enabled GSH monitoring in a live rat brain, and accurate GSH concentrations were firstly reported in different brain regions upon global cerebral ischemia. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Tanshinone I inhibits doxorubicin-induced cardiotoxicity by regulating Nrf2 signaling pathway

Author

Jiang, Qianqian, primary, Chen, Xu, additional, Tian, Xue, additional, Zhang, Jingmei, additional, Xue, Siming, additional, Jiang, Yanyan, additional, Liu, Tiantian, additional, Wang, Xiaoping, additional, Sun, Qianbin, additional, Hong, Yiqin, additional, Li, Chun, additional, Guo, Dongqing, additional, Wang, Yong, additional, and Wang, Qiyan, additional

Published
2022
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27. Shexiang Tongxin Dropping Pills Promote Macrophage Polarization-Induced Angiogenesis Against Coronary Microvascular Dysfunction via PI3K/Akt/mTORC1 Pathway

Author

Lu, Xiangyu, primary, Yao, Junkai, additional, Li, Changxiang, additional, Cui, Lingwen, additional, Liu, Yizhou, additional, Liu, Xiangning, additional, Wang, Gang, additional, Dong, Jianteng, additional, Deng, Qiong, additional, Hu, Yueyao, additional, Guo, Dongqing, additional, Wang, Wei, additional, and Li, Chun, additional

Published
2022
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28. Lung Changes in Ascites Syndrome in Broilers

Author

Guo, Dongqing, primary, Wang, Keyao, additional, Han, YuFeng, additional, Wang, Huimin, additional, Li, Peiqi, additional, Zhang, Jian, additional, Cui, Liang, additional, Deng, Ruiqiang, additional, Kang, Jie, additional, Zhou, Huaijun, additional, and Duan, Zhibian, additional

Published
2022
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30. Application of Taguchi method for optimization of process parameters in preparation of high-purity molybdenum disulfide

Author

Likang Fu, Jinhui Peng, Libo Zhang, Shixing Wang, and Guo Dongqing

Subjects
inorganic chemicals, General Chemical Engineering, chemistry.chemical_element, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Biochemistry, Industrial and Manufacturing Engineering, Taguchi methods, chemistry.chemical_compound, Impurity, Materials Chemistry, Molybdenum disulfide, Roasting, General Chemistry, 021001 nanoscience & nanotechnology, Copper, 0104 chemical sciences, enzymes and coenzymes (carbohydrates), chemistry, Molybdenum, bacteria, Particle size, Leaching (metallurgy), 0210 nano-technology, Nuclear chemistry
Abstract

A new purification method for molybdenum disulfide via NaNO3–HCl–HNO3 synergistic leaching at 80 °C was developed. The effects of the concentration of NaNO3, HCl, and HNO3, and liquid–solid ratio and the leaching time on the purification of molybdenum disulfide were investigated by orthogonal array design methodology. The results of Taguchi method utilizing L25 (55) orthogonal array indicated that the NaNO3 concentration had the greatest impact on the purification of molybdenum disulfide. The optimum conditions for the purification of molybdenum disulfide were as follow: concentration of NaNO3 = 2.5%, concentration of HCl = 11%, concentration of HNO3 = 1.0%, liquid–solid ratio = 3, and the leaching time = 10 h. Under optimum conditions, the content of molybdenum increased from 55.1 to 59%, and the contents of iron, copper, lead, and calcium decreased from 0.35 to 0.21%, 0.027 to 0.008%, 0.054 to

Published
2018

39. CRL4 antagonizes SCFFbxo7-mediated turnover of cereblon and BK channel to regulate learning and memory

Author

Song, Tianyu, Liang, Shenghui, Liu, Jiye, Zhang, Tingyue, Yin, Yifei, Geng, Chenlu, Gao, Shaobing, Feng, Yan, Xu, Hao, Guo, Dongqing, Roberts, Amanda, Gu, Yuchun, Cang, Yong, Song, Tianyu, Liang, Shenghui, Liu, Jiye, Zhang, Tingyue, Yin, Yifei, Geng, Chenlu, Gao, Shaobing, Feng, Yan, Xu, Hao, Guo, Dongqing, Roberts, Amanda, Gu, Yuchun, and Cang, Yong

Abstract

Intellectual disability (ID), one of the most common human developmental disorders, can be caused by genetic mutations in Cullin 4B (Cul4B) and cereblon (CRBN). CRBN is a substrate receptor for the Cul4A/B-DDB1 ubiquitin ligase (CRL4) and can target voltage- and calcium-activated BK channel for ER retention. Here we report that ID-associated CRL4CRBNmutations abolish the interaction of the BK channel with CRL4, and redirect the BK channel to the SCFFbxo7ubiquitin ligase for proteasomal degradation. Glioma cell lines harbouring CRBN mutations record density-dependent decrease of BK currents, which can be restored by blocking Cullin ubiquitin ligase activity. Importantly, mice with neuron-specific deletion of DDB1 or CRBN express reduced BK protein levels in the brain, and exhibit similar impairment in learning and memory, a deficit that can be partially rescued by activating the BK channel. Our results reveal a competitive targeting of the BK channel by two ubiquitin ligases to achieve exquisite control of its stability, and support changes in neuronal excitability as a common pathogenic mechanism underlying CRL4CRBN–associated ID.

Published
2018

40. Vascular endothelial growth factor signaling requires glycine to promote angiogenesis

Author

Guo, Dongqing, Murdoch, Colin E., Xu, Hao, Shi, Hui, Duan, Dayue Darrel, Ahmed, Asif, and Gu, Yuchun

Abstract

Peripheral vascular occlusive disease (PVOD) is a common manifestation of atherosclerosis, and it has a high rate of morbidity. Therapeutic angiogenesis would re-establish blood perfusion and rescue ischemic tissue. Vascular endothelial growth factor (VEGF) induces angiogenesis and can potentially be used to treat ischemic diseases, yet in clinical trials VEGF has not fulfilled its full potential with side effects. Whether amino acids promote angiogenesis and the molecular mechanisms are largely unknown. Here we showed that (1) Glycine significantly promoted angiogenesis both in vitro and in vivo and effectively protected mitochondrial function. (2) Activation of glycine transporter 1(GlyT1) induced by VEGF led to an increase in intracellular glycine. (3) Glycine directly bounded to voltage dependent anion channel 1 (VDAC1) on the mitochondrial outer membrane and inhibited its opening. These original results highlight glycine as a necessary mediator in VEGF signalling via the GlyT1-glycine-mTOR-VDAC1 axis pathway. Therefore, the findings in this study are of significance providing new mechanistic insights into angiogenesis and providing better understanding of glycine function in angiogenesis, which may provide valuable information for development of novel therapeutic targets for the treatment of angiogenic vascular disorders.

Published
2017

47. Role of epithelial Na+ channels in endothelial function

Author

Guo, Dongqing, Liang, Shenghui, Wang, Su, Tang, Chengchun, Yao, Bin, Wan, Wenhui, Zhang, Hailing, Jiang, Hui, Ahmed, Asif, Zhang, Zhiren, and Gu, Yuchun

Abstract

An increasing number of mechano-sensitive ion channels in endothelial cells have been identified in response to blood flow and hydrostatic pressure. However, how these channels respond to flow under different physiological and pathological conditions remains unknown. Our results show that epithelial Na+ channels (ENaCs) colocalize with hemeoxygenase-1 (HO-1) and hemeoxygenase-2 (HO-2) within the caveolae on the apical membrane of endothelial cells and are sensitive to stretch pressure and shear stress. ENaCs exhibited low levels of activity until their physiological environment was changed; in this case, the upregulation of HO-1, which in turn facilitated heme degradation and hence increased the carbon monoxide (CO) generation. CO potently increased the bioactivity of ENaCs, releasing the channel from inhibition. Endothelial cells responded to shear stress by increasing the Na+ influx rate. Elevation of intracellular Na+ concentration hampered the transportation of l-arginine, resulting in impaired nitric oxide (NO) generation. Our data suggest that ENaCs that are endogenous to human endothelial cells are mechano-sensitive. Persistent activation of ENaCs could inevitably lead to endothelium dysfunction and even vascular diseases such as atherosclerosis.

Published
2016

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