527 results on '"GULTEKIN, Murat"'
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2. Retinal dysfunction in Parkinson’s disease—results of the extended protocol for photopic negative response (PHNR) full-field electroretinogram (ERG)
- Author
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Polat, Osman Ahmet, Gultekin, Murat, Sener, Hidayet, Ozer, Furkan, and Arda, Hatice
- Published
- 2023
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3. Genital tract microbiota composition profiles and use of prebiotics and probiotics in gynaecological cancer prevention: review of the current evidence, the European Society of Gynaecological Oncology prevention committee statement
- Author
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Mitra, Anita, Gultekin, Murat, Burney Ellis, Laura, Bizzarri, Nicolò, Bowden, Sarah, Taumberger, Nadja, Bracic, Taja, Vieira-Baptista, Pedro, Sehouli, Jalid, and Kyrgiou, Maria
- Published
- 2024
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4. Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries
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Glasbey, James C, Abbott, Tom EF, Ademuyiwa, Adesoji, Adisa, Adewale, AlAmeer, Ehab, Alshryda, Sattar, Arnaud, Alexis P, Bankhead-Kendall, Brittany, Abou Chaar, M K, Chaudhry, Daoud, Costas-Chavarri, Ainhoa, Cunha, Miguel F, Davies, Justine I, Desai, Anant, Elhadi, Muhammed, Fiore, Marco, Fitzgerald, James Edward, Fourtounas, Maria, Fowler, Alex James, Futaba, Kay, Gallo, Gaetano, Ghosh, Dhruva, Gujjuri, Rohan R, Hamilton, Rebecca, Haque, Parvez, Harrison, Ewen M, Hutchinson, Peter, Hyman, Gabriella, Isik, Arda, Jayarajah, Umesh, Kaafarani, Haytham MA, Kadir, Bryar, Lawani, Ismail, Lederhuber, Hans, Li, Elizabeth, Löffler, Markus W, Lorena, Maria Aguilera, Mann, Harvinder, Martin, Janet, Mazingi, Dennis, McClain, Craig D, McLean, Kenneth A, Meara, John G, Ramos-De La Medina, Antonio, Mengesha, Mengistu, Minaya, Ana, Modolo, Maria Marta, Moore, Rachel, Morton, Dion, Nepogodiev, Dmitri, Ntirenganya, Faustin, Pata, Francesco, Pearse, Rupert, Picciochi, Maria, Pinkney, Thomas, Pockney, Peter, van Ramshorst, Gabrielle H, Richards, Toby, Roslani, April Camilla, Satoi, Sohei, Sayyed, Raza, Shaw, Richard, Simões, Joana FF, Smart, Neil, Sullivan, Richard, Sund, Malin, Sundar, Sudha, Tabiri, Stephen, Taylor, Elliott H, Venn, Mary L, Wickramasinghe, Dakshitha, Wright, Naomi, Yip, Sebastian Bernardo Shu, Bhangu, Aneel, Omar, Omar, Harrison, Ewen, Bhangu, Aneel A, Siaw-Acheampong, Kwabena, Benson, Ruth A, Bywater, Edward, Dawson, Brett E, Evans, Jonathan P, Heritage, Emily, Jones, Conor S, Kamarajah, Sivesh K, Khatri, Chetan, Khaw, Rachel A, Keatley, James M, Knight, Andrew, Lawday, Samuel, Mann, Harvinder S, Marson, Ella J, Mckay, Siobhan C, Mills, Emily C, Pellino, Gianluca, Tiwari, Abhinav, Trout, Isobel M, Wilkin, Richard JW, Abukhalaf, Sadi, Adamina, Michel, Ademuyiwa, Adesoji O, Agarwal, Arnav, Akkulak, Murat, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeier, Markus, Alser, Osaid, Alshaar, Muhammad, Augestad, Knut Magne, Ayasra, Faris, Azevedo, José, Bankhead-Kendall, Brittany K, Barlow, Emma, Beard, David, Blanco-Colino, Ruth, Brar, Amanpreet, Minaya-Bravo, Ana, Breen, Kerry A, Bretherton, Chris, Buarque, Igor Lima, Burke, Joshua, Caruana, Edward J, Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Davidson, Giana H, Di Saverio, Salomone, Drake, Thomas M, Edwards, John G, Emile, Sameh, Farik, Shebani, Ford, Samuel, Garmanova, Tatiana, Gomes, Gustavo Mendonça Ataíde, Grecinos, Gustavo, Griffiths, Ewen A, Gruendl, Magdalena, Halkias, Constantine, Hisham, Intisar, Hutchinson, Peter J, Hwang, Shelley, Jenkinson, Michael D, Jonker, Pascal, Keller, Debby, Kolias, Angelos, Kruijff, Schelto, Leventoglu, Sezai, Litvin, Andrey, Loehrer, Andrew, Major, Piotr, Mashbari, Hassan N, Metallidis, Symeon, Mohan, Helen M, Moszkowicz, David, Moug, Susan, Ng-Kamstra, Joshua S, Maimbo, Mayaba, Negoi, Ionut, Niquen, Milagros, Olivos, Maricarmen, Oussama, Kacimi, Outani, Oumaima, Parreno-Sacdalanm, Marie Dione, Rivera, Carlos Jose Perez, Pinkney, Thomas D, Plas, Willemijn van der, Qureshi, Ahmad, Radenkovic, Dejan, Revell, Elliot J, Roberts, Keith, Roslani, April C, Rutegård, Martin, Segura-Sampedro, Juan José, Santos, Irène, Schache, Andrew, Schnitzbauer, Andreas A, Seyi-Olajide, Justina O, Sharma, Neil, Shaw, Catherine A, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Stewart, Grant D, Townend, Philip, Tsoulfas, Georgios, Vidya, Raghavan, Vimalachandran, Dale, Warren, Oliver J, Wedderburn, Duane, EuroSurg, NA, European Society of Coloproctology (ESCP), NA, Global Initiative for Children's Surgery, NA, GlobalSurg, NA, GlobalPaedSurg, NA, ItSURG, NA, PTSurg, NA, SpainSurg, NA, Italian Society of Colorectal Surgery, NA, Association of Surgeons in Training, NA, Irish Surgical Research Collaborative (ISRC), NA, Transatlantic Australasian Retroperitoneal Sarcoma Working, NA, Italian Society of Surgical Oncology, NA, Booth, Lesley, Barker, Margaret, Barker, Neil, Cooke, Shirley, Doré, Suzanne, Horwood, Nigel, Runigamugabo, Emmy, Weir, Carrie Tierney, Bahrami-Hessari, Mike, Riaz, Asad, Shah, Jaffer, Safi, Mohammed, Thereska, Dariel, Dajti, Irida, Cheddadi, Riadh, Tidjane, Anisse, Quinteros, Carlos A, khelfaoui, Ahmed, Salem, Khalifa M, Riffi, Omar, Kacimi, Salah Eddine O, Loudjedi, Salim, Damerdji, Tidjani, Pantoja Pachajoa, Diana A, Palacios Huatuco, René M, Alvarez, Fernando A, Doniquian, Alejandro M, Abeldaño Zuñiga, Roberto A, Schlottmann, Francisco, Cobos, Carlos M, Gigena, Cecilia, Forneris, Agustin Albani, Duro, Agustin, García-Mansilla, Agustín M, Busnelli, Virginia Cano, Poggi, Catalina, Mercado, Pedro L, González, Marcos, Castro Lalin, Agustina F, Mayer, Horacio F, Brandariz, Rodrigo, Slullitel, Pablo A, Boudou, Rocio, Lobos, Pablo A, Uffelmann, María C, Petersen, Maria L, Luzzi, Emilia, Padilla Lichtenberger, Fernando L, Crespi Amor, María S, Zarratea, Celeste S, Esteves, Tomas A, Gemelli, Nicolas A, Tirapegui, Sebastián, Liyo, Juan, Scherñuk, Jordán, Boccalatte, Luis A, Balmaceda, Ruben D, D'Addino, Jose L, Caubet, María M, Calderón Arancibia, José A, Chwat, Carina, Morris, Brian, Avellaneda, Nicolas, Pedraza Salazar, Ivana I, Eskinazi, Diego G, Vargas, Lara, Muriel, María E, Lucchini, Sergio M, Gosselink, Martijn P, Davis, Amelia L, Barker, John C, Qin, Kirby R, Proud, David M, Cox, Daniel RA, Goh, Su Kah, Liu, David S, Wu, Damien M, Merrett, Neil D, Badiani, Sarit S, Sengupta, Shomik, Jain, Anshini, Steen, Christopher J, Wong, Enoch, Ip, Christopher CK, Leaning, Matthew G, McCartney, Conor B, Gananadha, Sivakumar, Yeap, Evie FW, Stevens, Sean G, Vu, Anh N, Martin, Sarah A, Stanley, Guy H M, Watson, David I, Townend, Philip J, Young, Thomas K, Cox, Georgia T, Dawson, Amanda C, Laura, Sharon E, Lun, Elizabeth W Y, Liang, Ina X, O'Neill, Christine J, Lott, Natalie J, Chuan, Alwin, Saravanan, SK, Gundara, Justin, Ong, Bee Shan, Nataraja, Ramesh M, Pacilli, Maurizio, Foley, Daniel M, Ooi, Geraldine J, Traeger, Luke, MacDermid, Ewan, Daruwalla, Jurstine, Hodgson, Russell, Heriot, Alexander G, Mulligan, Christopher S, Blefari, Nicholas D A, Purcell, Shaun S, Frankel, Adam J, Guerra, Glen R, Tefay, Joan S, Liang, Rhea W Y, Kroon, Hidde M, Farfus, Anthony W, Warren, Leigh R, Roy, Jennifer M, Whitfield, Robert J, Moller, Cea-Cea B, Davis, Sean S, Sammour, Tarik, Lam, Yick Ho, Kour, Kevin, Gan, Siang Wei, Coventry, Brendon J, Dawson, Joseph A, Batstone, Martin D, King, Sebastian K, Scott, Nathan J, Foo, Jonathan W, Shepherd, Talia, Page, Richard S, Choong, Peter F, Badgery, Henry E, Chong, Lynn, Taylor, Lillian, Hii, Michael W, Wright, Gavin M, Kong, Joseph CH, Watson, Matthew M, Bock, Jacob, Lidder, Surjit S, Elias, Patrick, Kanavathy, Sathisvaran, Koh, Cherry E, Chennakesavan, Srinivas Kondalsamy, Panuganti, Vishwakar, Latif, Haider, Yeung, Justin MC, Besson, Alex J, Tse, Eunice Q Y, Pitcher, Meron E, Taylor, Danielle L, Nahm, Christopher B, Lim, Alicia, Tree, Kevin, Aigner, Felix, Dawoud, Christopher, Foessleitner, Philipp, Zimmermann, Matthias, Wiedemann, Dominik, Findl, Oliver, Messner, Franka, Bauer, Marlies, Nägele, Felix, Kronberger, Irmgard E, Öfner, Dietmar, Härter, Bettina, Bicz, Nina Ru B, Zwittag, Paul M, Poier, Nikolaus, Navarro, Francisco Ruiz, Zebuhr, Yorck A, Köglberger, Paul, Wiesinger, Clemens G, Mathew, Erwin, Trivik-Barrientos, Felipe, Königsrainer, Ingmar, Djedovic, Gabriel, Cohnert, Tina U, Lumenta, David B, Singer, Georg, Leithner, Andreas, Kamolz, Lars-Peter, Andrianakis, Alexandros, Puchwein, Paul, Mikalauskas, Saulius, Kirchweger, Patrick, Függer, Reinhold, Mittermair, Christof, Russe, Elisabeth, Paal, Peter, Grünbart, Martin, de Cillia, Michael, Weiss, Helmut G, Steiner, Florian, Binder, Alf Dorian, Samadov, Elgun, Ibrahimli, Arturan, Muslumov, Gurbankhan, Bayramov, Nuru Y, Saunders, Jada M, Almoosa, Noora, Haj-Ibrahim, Huzifa, Maresch, Martin, Ezzdean, Weaam K, Juma, Isam M, Hasan, Layla H, Haider, Fayza HA, Alfaqawi, Ghassan Salman, Alam, Mohammed S, Islam, Shahnoor, Basher, AKM K, Mitul, Ashrarur Rahman, Islam, Nazmul, Oosterkamp, Antje E, Ahmed, Tanveer, Hannan, M Jafrul, Padmore, Greg M, Doyle, Alex F, LaCorbiniere, Karisha L, Boyce, Rico D R, Ragoobar, Paul T, Walkes, Keisha M Y, Haynes, Amelia A, Corbin, Sasha M, Litvina, Yauheniya A, Makhmudov, Anvar, Strypstein, Sébastien, Dhondt, Bert, Rasschaert, Ricky, Farid, Yasser, Wahib, El Mahdi, Pigeolet, Manon, Belle, Koen Van, De Wachter, Stefan, Komen, Niels, Vandeputte, Mathieu PJ, Jansen, Yanina JL, Stijns, Jasper, Eynde, Jef Van den, Olowo, Benedicte I, Feraudy, Israel C, Dragisic, Vedran, Martinovic, Vlatka, Barišić, Tatjana, Penava, Nikolina, Hudic, Igor, Delibegovic, Samir, Bogdanović, Gordana, Grgić, Gordana, Cerovac, Anis, Cerovac, Elmedina, Bedada, Alemayehu G, Baiocchi, Glauco, Wainstein, Alberto, Moisés, Elaine Christine D, Zani, Ana Carolina Tagliatti, de Campos Prado, Caio Antonio, Panis, Carolina, Rech, Daniel, Soares da Silva, Ruan Gabriel, Joviliano, Edwaldo E, Rezende, Ricardo F, Reis, Igor G N, Pires, Robinson E S, Christiano, Adriana Borgonovi, Consani, Heitor F X, Pugliesi, Felipe G, Takeda, Flavio R, Mariani, Alessandro W, Valadares, Ricardo J B, Andreollo, Nelson A, Lopes, Luiz Roberto, Tonello, Cristiano, Alonso, Nivaldo, dos Santos, Carlos Ferreira, Lima, Leonardo S, Salgado, Wilson, Pereira, Thiago H S, Gatti, Arthur Paredes, Oliva, Ramon N L, Nardi, Caroline N, Sousa, Alvaro F L, Ribeiro, Ivonizete P, Carvalho, Herica E F, Oliveira, Layze B, Schneider, Guilherme, Casteleins, William Augusto, Silva, Larissa M, Gomes, Carlos Augusto, da Cunha Viana Júnior, Alonço, Cruz, Ricardo P, Gomes, Gustavo MA, Buarque, Igor L, Barros, Aldo V, Marangon, Gustavo B, Flumignan, Ronald LG, Nakano, Luís CU, Pascoal, Patrícia IF, Santos, Brena C, Kuramoto, Danielle AB, Correia, Rebeca M, Amaral, Fabio CF, Flumignan, Carolina DQ, Dussán-Sarria, Jairo A, Simões, Romeo L, Amorim, Robson L, Silva, Jeancarllo S, Lyra Junior, Humberto F, Julio, Nathalia S, Gerber, Marlus T, dos Santos, José Mauro, de Oliveira, Joao Carlos C, Palamim, Camila VC, Marson, Fernando AL, Gomes, Iolanda M, Oliveira, Priscila R, Lima, Ana Lucia L M, Carvalho, Vladimir C, Silva, Jorge S, NA, Ulysses Ribeiro, Laporte, Gustavo Andreazza, Gonçalves, Mateus Capuzzo, Botacin, Lais S, Avelino, Melissa AG, Brito, Luiz Gustavo O, Hristova, Evguenia T, Stoyanov, Vladislav Valentinov, Sakakushev, Boris E, Dardanov, Dragomir D, Sokolov, Manol B, Mehta, Ananya, Gyokova, Elitsa H, Abdullahi, Mohamed, Karamanliev, Martin P, Dimitrov, Dobromir D, Slavchev, Mihail T, Atanasov, Boyko Ch, Yotsov, Tsanko I, Hadzhiev, Dimitar Bozhidarov, Stock, Simon E, Nwegbu, Chukwuemeka Gerald, Tanyi, Tanyi John, Brown, James A, Arneja, Jugpal S, Lee, Susan M, Kancherla, Ramya, Kidane, Biniam, Champagne, Pierre-Olivier, Ma, Xiya, Munro, Allana, McKeen, Dolores M, Glinka, Juan, Vasarhelyi, Edward M, Subramani, Yamini, Alfaro, Hilda, Shah, Ushma J, Gonzalez, Nelson J, MacNeil, S Danielle, Nagappa, Mahesh, Malthaner, Richard A, Brackstone, Muriel, Alkhamesi, Nawar A, Qiabi, Mehdi, Arango-Ferreira, Camila, Prempeh, Agya B A, Dumitra, Sinziana, Spence, Richard T, Bedard, Eric LR, Luc, Jessica GY, Johnston, Brian R, Attabib, Najmedden, Persad, Amit RL, Das, Sunit, Khoshbin, Amir, Ladha, Karim S, Sankar, Ashwin, Teja, Bijan, Daza, Julian F, Chan, Veronica F, Baertschiger, Reto M, Zani, Augusto, Nessim, Carolyn, McIsaac, Daniel I, Singh, Mandeep, Behzadi, Abdollah, Dell, Angela J, Al Riyami, Salim M, Dajani, Khaled Z, Bigam, David, Manikala, Vinod K, Street, John T, Mayson, Kelly V, Wallis, Christopher J D, Mimica, Ximena, Villanueva, Julio, Altamirano, Roberto, Waissbluth, Sofia, Marín, Diego I, Fonseca, Bruno Catoia, Hodali, Andrés J, Ramos, Andrea I, Valenzuela, Marco A, Torres, Janina J, Song, Yi, Yang, Wah, Aldanakh, Abdullah, Alradhi, Mohammed, Lyu, Yidong, Chen, Yan, Fletcher, Angélica V, Camargo, Daniela, Casanova, Rafael Figueroa, Medina, Camilo Andres Caicedo, Bolivar, Dinimo, Garcia, Tatiana Carolina Beltran, Pedraza, Nestor F, Garcia-Lopez, Andrea, Patino-Jaramillo, Nasly G, Giron, Fernando A, Rivera, Carlos J- Perez, Nieto-Calvache, Albaro José, Ariza, Fredy, Orozco-Chamorro, Claudia Milena, Nanez, Maria A, Garces, Diana S, Figueroa, Luis M, Badiel, Marisol, Martinez, Delio F, Coll-Tello, Brenda, Camelo, Hector F, Montoya Casella, Antonio J, Ordoñez, Sebastian, Velez Sanchez, Paola A, Salcedo, Juan C, Villegas, Lina M, Holguín, Jorge A, Cardozo, Jesús Hernán Tovar, Perdomo, Jorman Harvey Tejada, Perdomo, Valentina Gutiérrez, Rivera-Rincon, Natalia A, Gomez, Paula Torres, Delgado-Nieto, Elena Leonor, Isaza-Restrepo, Andres, Vargas, Felipe, Vargas, Ana M, Castro, Arnulfo Andrade, Navarro, Jorge A, Vargas, Saul E, Calvache, Jose A, Mendoza-Arango, Maria C, Bernal, Jorge Luis Vélez, Gonzalez, Felipe O, šantak, Goran, Kirac, Iva, Kršul, Dorian, Versic, Ana Bosak, Augustin, Goran, Kulis, Tomislav, Kastelan, Zeljko, Hadzibegovic, Ana Danic, Grsic, Kresimir, Hudolin, Tvrtko, Tarle, Marko, Mamic, Matija, Lorencin, Mia, Luksic, Ivica, Habek, Dubravko, Konjevoda, Suzana, Mihanovic, Jakov, Antoniou, Stavros A, Almezghwi, Heyam A, Gouvas, Nikolaos, Martinek, Lubomir, Novysedlak, Rene, Žatecký, Jan, Meyhoff, Christian S, Ellebæk, Mark Bremholm, Batista, Sylvia Jeanne, Rodriguez, Julia, Mejia De la Cruz, Dolores, Jimenez, Mirna Giselle Santiago, Dominguez, Carla M, Negrete, José R, Campuzano, Pedro N, Mogrovejo, Daniel L, Armas, Maria J, Arboleda-Bustan, Jenny E, Lincango-Naranjo, Eddy P, El-Kassas, Mohamed, Awad, Ahmed K, Alazab, Emad, Abdulmaseh, Kyrillos G, Diab, Sherein, El Wahab, Mostafa HAbd, Darwesh, Amr, Mostafa, Badr E, Abdelgalil, Mahmoud Shaban, Elbadawy, Merihan A, Reda, Ali M, Asla, Amir Fathi, Fayed, Notaila M, Ahmed, Mohamed S, Elsadek, Menan Ahmed, Gad, Dalia Elsayed, El Saadany, Aya Gameel, Elsadek, Aalaa Mohamed, Sayed, Ahmed E, Naeem, Ahmed, Al-Mallah, Abdullah, Abdelsamed, Ahmed A, Ewedah, Moataz, Soliman, Mohamed O, Tanas, Yousef, Hamouda, Mohammed, Mahfouz, Marina H, Abdo, Manal E, Dean, Yomna E, Lka, Karim, Abodeeb, Aya O, Ashoush, Fouad M F B, Elsherbiny, Roqaia R, Gadelkarim, Mohamed, Osman, Nermin A, MIbrahim, Maya, Youssef, Nehal G, Ibrahim, Mohamed Hamdy, Soliman, Antonios, Gadelkareem, Rabea A, Abbas, Ahmed M, Mohamed Hussein, Aliae AR, Abdelsattar, Khaled, Maher, Ahmed, Elabd, Mohamed M, Abdelazim, Hassan, Ibraheem, Maher H, Noureldin, Yasser A, Elfiky, Mahmoud, Ebrahim, Mohamed A, Abdelrahman, Ahmed Saber Mohamed, Marei, Mahmoud Marei, Elkhalawy, Aya M, Azzam, Ahmed Y, Azab, Mohammed A, Elmasry, Ahmed H, Elgazar, Amr, Shalaby, Mahmoud Mohamed Mohamed, Mahmoud, Mohammad S, Qassem, Mohamed G, Kinani, Hussein, Wahba, Abdelrahman M, Ezzat, Rana Hisham, Ahmed, Mai H, Elshawy, Mohamed Elemam, Faragalla, Hazem Metwally, Mahmoud, Khalid D, Nafea, Ahmed M, Abdel-Maboud, Mohamed, Abozied, Hesham, Moharam, Modather, Shehata, Ashraf H, ElKafrawy, Samir A, Tayiawi, Mosaab M, Elghadban, Hosam M, Emara, Moataz M, Shehta, Ahmed, Saqr, Amira M, Abdelelsalm, Wafaa M, Elshennawy, Eslam M, Radwan, Samar T, Awad, Selmy S, Emile, Sameh H, Aldosoky, Wesam A, Elfeki, Hossam, Gendi, Sara N, Abdelsalam, Hala Adel, Hammad, Mohammed, Shalaby, Mostafa, Sakr, Ahmad Hammad, Abdelmaksoud, Mohamed A, Alawady, Mohammed, Omran, Abdelrahman Azzam, Allam, Abdallah R, Ismail, Zainab, Gaballah, Khaled M, AlGady, Mahmoud Fathy Mahmoud, Raslan, Ahmed M, Gharbia, Khaled, Nuser, Abdelazez A, Sayed, Ahmed Kamal, Elshahawy, Mahmoud A, Ghaly, Galal, Sherif, Ahmed Elshawadfy, Makram, Abdelrahman M, Makram, Omar M, Ahmed, Ola, Helmy, AbdelRahman M A, Abdelwahab, Khaled M, Abdelkhalek, Mohamed, Metwally, Islam H, Shetiwy, Mosab Saad, Zuhdy, Mohammad, Ramadan, Salma I, Abdelghany, Mohamed, Omar, Mohammed A, Soliman, Ziad A, Ali, Hossam T, Elnoamany, Salma, Ghozy, Sherief, Abbas, Alzhraa S, Shehata, Mostafa A, Mahmoud, Sahar A, Elsaman, Mohammed A, Fayad, Elsayed A, Radwan, Asmaa, El-Sakka, Ahmed I, Sallam, Asser, Elbahnasawy, Mohamed G, Esmail, Eslam S, Hawila, Ahmed Maher, Hamada, Mohamed K, Motawea, Sara H, Morsy, Mohamed S, El-Sheemy, Hatem Refaat, Ebada, Mahmoud Ahmed, Khedr, Ali H, Gad, Ahmed, Elmandouh, Omar, Elmandouh, Reem, Alkanj, Souad, Youssef, Mohammad G, Awad, Kamal, Mohammed, Maged, Elsayad, Ahmed H, Rätsep, Tõnu, Wolle, Melatework A, Negussie, Abraham G, Adimass, Misganaw A, Misganaw, Bereket Tsegaye, Bezabih, Yoseph S, Assefa, Biniam Zemedu, Shumye, Getachew W, Mengesha, Mengistu G, Gechera, Dagnachew Y, Mohammed, Adnan A, Mulugeta, Gersam A, Metaferia, Yonas Y, Kifetew, Ashebir B, Degefa, Eyueal A, Deressa, Yadani M, Gonfa, Kebebe Bekele, Bedane, Zewdie G, Ayalew, Alem M, Ayele, Henok Teshome, Abebe, Engida, Worku, Bereket Atnafu, Sisay, Million M, Kassa, Dawit Worku, Awedew, Atalel F, Bayable, Abera C, Tiruneh, Abraham Genetu, Hailu, Samuel, Numaro, Yilkal T, Ademe, Yonas, Baleh, Abat S, Megerssa, Thomas B, Kejela, Segni, Derilo, Habtamu T, Akililu, Yemisirach B, Lebbe, Iris, Sarjanoja, Elise K, Kauppila, Joonas H, Sinikumpu, Juha-Jaakko, Giordano, Salvatore, Kantor, Elie, Soussan, Romy, Tommaso, Cipolat Mis, Nappi, Francesco, Morichau-Beauchant, Tristan, Nahum, Julien, Maillet, Jean-Michel, Godement, Mathieu, Jouffret, Lionel, Migliorelli, Federico, De Simone, Belinda, Brunaud, Laurent, Fuchs-Buder, Thomas, Testelin, Sylvie, Bin, Kim, Boucher, Sophie, Schmitt, Françoise, Lakkis, Zaher, Harper, Luke, Slim, K, Piessen, Guilaume, Eveno, Clarisse, Ballouhey, Quentin, Taibi, Abdelkader, Crenn, Vincent, Duchalais, Emilie, Azzis, Olivier, Tuech, Jean-Jacques, Vaysse, Charlotte, Weyl, Ariane, Vergriete, Kelig, Charbonneau, Helene, Ezanno, Anne-Cecile, Malgras, Brice, Basso, Celeste Del, Duquesne, Igor, Bernabei, Federico, Rothschild, Pierre-Raphaël, Abbo, Olivier, Manceau, Gilles, Chamouni, Alexandre, Crétolle, Célia, Arnalsteen, Laurent, Mikhael, Elie, Police, Andrea, Montero-Macias, Rosa, Villefranque, Vincent, Maisonneuve, Emeline, Langlais, Tristan, Seeliger, Barbara, Pessaux, Patrick, Gonzalez, Cristians A, D'Urso, Antonio, Angeles, Martina A, Seguin-Givelet, Agathe, Des Deserts, Marc Danguy, Gaujoux, Sebastien, de Ponthaud, Charles, Chartier-Kastler, Emmanuel J, Ali, Liza, Peycelon, Matthieu, Mege, Diane, Demetrashvili, Zaza, Stoleriu, Mircea G, Keppler, Lena, Saier, Tim, Konrads, Christian, Tapking, Christian, Kamphues, Carsten, Bulian, Dirk R, Schmedding, Andrea, Doerner, Johannes, Gut, Anna E, Rolinger, Jens, Kirschniak, Andreas, Schröder, Lars, Reim, Daniel, Safi, Seyer, Fichter, Andreas M, Wagner, Arthur, Meyer, Bernhard, Gempt, Jens, Sablotzki, Armin R, Herzberg, Jonas, Altenburg, Manuel, Yenilmez, Ferhat, Meins, Jan, Aghwan, Louai A, Börner, Nikolaus, Keppler, Alexander M, Seyfried, Steffen, Rassweiler-Seyfried, Marie-Claire, Kriegmair, Maximilian, Kowalewski, Karl-Friedrich, Gousias, Konstantinos, Strotmann, Johanna J, Höhn, Philipp, Horn, Julian, Knipschild, Julia M, Siemen, Leonie, Luu, Andreas Minh, Horch, Raymund E, McLean, Aaron Lawson, Lindert, Judith Anne Teresa, Ziemann, Sebastian, Modabber, Ali, Winnand, Philipp, Hölzle, Frank, Sommer, Björn, Wolf, Sebastian, Shiban, Ehab, Recker, Florian, Güresir, Erdem, Randau, Thomas M, Güresir, Agi, Velten, Markus, Vilz, Tim O, Wittmann, Maria, Willis, Maria A, Glowka, Tim R, Bork, Ulrich, Hecker, Matthias, Hecker, Andreas, Reichert, Martin, Miller, Clemens, Nemeth, Marcus, Ronellenfitsch, Ulrich, Kleeff, Jorg, Lorenz, Kerstin, Kisser, Ulrich, Schneider, Rick, Seiwerth, Ingmar, Osterhoff, Georg, Linz, Valerie C, Mallmann, Michael R, Rokohl, Alexander C, Heindl, Ludwig M, Wawer Matos, Philomena A, Cursiefen, Claus, Mallmann, Christoph A, Domroese, Christian M, Königsrainer, Alfred, Yurttas, Can, Thiel, Karolin, Vahl, Julius M, Wiegering, Armin, Lock, Johan F, Heuer, Annika, Reiter, Alonja, Stangenberg, Martin, Böttcher, Arne, Kaemmerer, Daniel, Mensah, Kofi T, Gyamfi, Frank E, Opandoh, Isabella N M, Ofori, Emmanauel O, Baidoo, Ebikela I, Baidoo, Richard O, Azize, Diallo A, 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Enoch F, Pushpoth, Sreekumari R, Viswanath, Yirupaiahgari KS, ElSanhoury, Kareem, Chew, Misha, Walker, Thomas E, Elhassan, Almutasim Billah Elbagir, Belcher, Elizabeth, Goricar, Matej, majd, Hooman Soleymani, Knight, Dominic, Ismail, Lamiese, McKinnon, Chris, Ganau, Mario, Prokopenko, Max, Doshi, Neel S, Gkorila, Aikaterina, Sheikh, Nomaan A, Helm, Jessica R, Low, Mei Ken, Ogunfusika, Oluseyi Harold, Bisheet, George, Alhammali, Tariq, Arnob, Ahmed Showki, Singh, Jatinder, Allde, Emma L, Sambhwani, Sharan H, Dube, Manas, Gemmill, Elizabeth H, John, Joby, Gerogiannis, Ioannis N, Abuelgasim, Mona A A, Crate, Georgina, Holme, Thomas J, Nguyen, Anh T V, Ho, Michael W, Wade, Ryckie G, Hussain, Azar, Andrzejowski, Paul, Omakobia, Eugene, Eltayeb, Momin, Galabov, Tsanko P, Lee, Chung Yan Vernon, Nazir, Anum, Siaw, Oliver L, Ashford, Robert U, Boddy, Alex P, Ashmore, Christopher D, Shah, Snehadhar M, Gowers, Benjamin T V, Thekkinkattil, Dinesh K, Worku, Dawit, Harky, Amer, Talwar, Rishi, Sagoo, Harkiran K, Jambulingam, Periyathambi S, Smart, Christopher J, Doherty, Daniel T, Mastoridis, Sotiris, Kumar, Sidharth, Mahmoud, Rana, Solari, Francesca, Egan, Richard J, Barry, Jonathan D, Morrison, Jo, Davoudi, Kaveh, Hollyman, Marianne, Kelly, Andrew, Badenoch, Thomas F, pandanaboyana, sanjay, Critchley, Rebecca J, Sarodaya, Varun R, Sinnerton, Robert J H, Manickavasagam, Jaiganesh, Lindsay, Elizabeth F, Arora, Ankita, Hasan, Raashad, Liew, Ignatius, Ozua, Joshua, Kouritas, Vasileios, Collins, Rachael V, Lafford, George H, Moret, Charlie, Chean, Chung Shen, Horgan, Liam F, Aujayeb, Avinash, Siddique, Muhammad Harris, Navaratne, Lalin, Kotecha, Sanjeev, Bellato, Vittoria, Lewis, Sophia E, Ali, Muhammad Usman, Marson, Ben A, Craxford, Simon, Gajjar, Ketankumar, Theophilidou, Elena, Aboelmagd, Tariq, Khatkar, Harman, Awadallah, Mahmoud A, Blanco, Jose A, Chituku, Tsitsi G, Dixon, Oliver GB, sarveswaran, Janahan, Jones, Imogen S, Hammouche, Salah, Vijay, Vardhini, Ooi, Rucira, Karmarkar, Rahi, Khaleeq, Tahir, Bhatia, Mohit, Al-Khazaali, Badr L, Daadipour, Audrina, Mattar, Ahmed, Singhal, Tarun, Mahmoud, Moustafa Ibrahim, Glasbey, James, Nankivell, Paul C, Kalkat, Maninder S, Nour, Shahd, Beggs, Andrew D, Yershov, Danylo Y, Chughtai, Shafiq Ahmad, Youssef, Hesham, Norrish, Alan R, Mohammed, Mohammed M, Gwozdz, Adam M, Charalambous, Michalis P, Knight, Stephen R, McCaul, James A, Bridgman, Elsie A, El Sheikh, Mustafa, Ogunbowale, Akinsola, Wright, Evan O, Ahmed, Usama, Younus, Hafsa, Tincknell, Laura G, Weixing-Ho, Ken, Demetriou, Charis, Hussei, Mohammed, Reilly, John-Joe, Hormis, Anil P, Moug, Susan J, Anazor, Fitzgerald C, Horwell, Edward A, Neal-Smith, Gregory, McNamara, John M, Baryeh, Kwaku W, Bhatti, Khalid M, McKay, Joseph E, Cannoletta, Maria G, Perkins, Clare J, Gopalswamy, Sivakumar, Sheldon, Anna F, John, Joseph B, Mantle, Mark, Toia, Bogdan, Phillips, Andrew J, Al-Khyatt, Waleed, Lund, Jonathan N, Ammar, Ahmed Y, Yim, Guang H, Huntley, Daniel A, Daniels, Ian R, Valverde, Joao, Lumley, Edward David John, Walton, Thomas J, Raptis, Dimitri A, Dimitrokallis, Nikolaos, Nathan, Arjun, Motallebzadeh, Reza, Chowdhury, Shihab, Ahmed, Rezwan F A, Mirnezami, Reza, Szakmany, Tamas, Knight, Dominic J, Al-Azzani, Waheeb, Davies, Huw R, Ooi, Setthasorn Zhi Yang, Oo, Khaing K, Cullis, Paul S, Peng, Ed, Demetriades, Andreas K, Tambyraja, Andrew L, Poon, Michael TC, Brennan, Paul M, Oikonomou, Dimitrios, Newman, Samuel E, Le Blevec, Louise, Otify, Mohamed, Szatmary, Peter, Devkaran, Bhavesh, Sochorova, Dana, Sohrabi, Catrin, Sivaprakasam, Rajesh, Goh, Mingzheng Aaron, Atkinson, Kate V, Soares, Delvene, Prce, Daniela, Cann, Johnathon P, Grobbelaar, Amy C, Bradley, Rebecca, Strauss, Helen J, Taha, Ahmed, Minicozzi, Annamaria, Thakur, Bhaskar, Hanoun, Abdullah, Goru, Poornanand, Baumber, Rachel M, Sobti, Anshul S, Cross, George WV, Havenhand, Tom, Antoniou, George A, Chauhan, Govind Singh, Vokshi, Ismail, Mahmud, Ayesha, Albanese, Erminia, Evans, Daisy, Madhuri, Thumuluru Kavitha, Horsnell, Jonathan D, Zalmay, Pardis, Davies, Angharad J, Aljanadi, Firas, Jeganathan, Reubendra, Jones, Mark, Kakos, Christos, vidya, Raghavan, El-Ghobashy, Alaa, Habib, Ahmed M, Reid, Jeremy P, Rajgor, Harshadkumar Dhirajlal, Ahmed, Omar, Branagan, Graham, Mohamedahmed, Ali Yasen Y, Al-Sabbagh, Ali, Chetty, Govind, Kelty, Clive J, EL-Wajeh, Yasin A M, Tomlinson, James E, Rominiyi, Ola, Sinha, Saurabh, Saad, Sanad, Sahu, Banchhita, Charalampakis, Vasileios, Enemosah, Ibrahim, Williams, Simon J, Yaqoob, Hassan N, Laurent, Edward P, Moreau, Joshua L, Frostick, Rhiannon, Parwaiz, Hammad, Aboelmagd, Karim, Pournaras, Dimitri J, Hristova, Kalina H, Iyengar, Karthikeyan P, Mohamed, Muyed, Artioukh, Dmitri Y, Anwar, Sibtain, Hussein, Mostafa K A, Omogbehin, Tomisin S, Herron, Jonathan B T, Labib, Amir, Patel, Preemal, Marsden, Samuel C, Mehdian, Roshana, Santhirakumaran, Gowthanan, Smelt, Jeremy, Agarwal, Ketan, Lancerotto, Luca, Sahnan, Kapil, Shalhoub, Joseph, Donnelly, Liam J, Erridge, Simon, Chidambaram, Swathikan, Luo, Xun, Bansal, Sujesh, Ryan, Neil AJ, Smith, Alexander C D, Flatman, Michael, Wafaie, Imad, Malik, Muhammad Isfandyar Khan, Thumbadoo, Ruben P, Hussain, Shoaib F, Henein, Christin, Hamad, Yousif T, Belgaumkar, Ajay P, Bosanquet, David C, Kolias, Angelos G, Choi, David, Marcus, Hani J, Horsfall, Hugo RM Layard, Khan, Danyal Z, Sahni, Arun, Millward, Christopher P, Render, Luke, Truss, Adam, Elmoslemany, Tarek, Parmar, Chetan, Hanger, Joseph, Sheen, Jonathon, Rait, Jaideep S, Foreman, Jennifer, Marzouqa, Natalie, Fontalis, Andreas, Voulalas, Grigorios, CHEONG, Ryan Chin Taw, Dindyal, Sanjay, Arumugam, Sathyaseelan, Ward, Thomas R W, Stephens, Alastair S, Douka, Eleftheria, Abou-Foul, Ahmad K, McKay, Siobhan C, Kitchen, Mark O, Rees-Stoner, Oliver DJ, Balasubramanya, Supriya, Akhtar, Muhammad Adeel, Warwick, Andrew J, Pawar, Shweta, Dubey, Vivek, Al-Yaseen, Mustafa W, Williams, Christopher YK, Laird, Alexander, Krishna, Kandaswamy, Anyaugo, Ngozi S, Wuraola, Obafemi K, Odejinmi, Funlayo, Craven, Joanna M, West, Charlotte L, Barter, Reece A, Navaratnam, Devaraj M, Malik, Shahbaz S, Mahendran, Vimaladhithan, Zilvetti, Miguel, Lovegrove, Richard E, Board, Tim N, Zeiton, Moez, Sarwar, Safdar A, Duff, Sarah E, Hsabo, Elmuiz A, Nugur, Ashwani Kumar, Morris, Richard M, Lala, Anil K, Kwan-Feinberg, Rita O, Ross, Samuel W, Dressler, Jeremy A, Evans, Faye M, Wason, Shaun E L, Vogel, Keianna R, Wang, Joanna C, Sulciner, Megan L, Hirji, Sameer, Raoof, Mustafa, Wolff, Christopher J, kent, Ilan, Turan, Alparslan, Teixeira, Pedro G, Olson, Kristofor A, Patel, Neil D, Krishnamoorthy, Vijay, Moris, Dimitrios, Rice, Henry E, Gabr, Hesham, Satoskar, Savni R, Castater, Christine A, Jmaileh, Manal, Payne, Rachel E, Kwon, David S, Aarabi, Shahram, Escobar, Pedro F, Kronenfeld, Joshua P, Dalton, Michael K, Etchill, Eric W, Haut, Elliott R, Vervoort, Dominique, Dehal, Ahmed, McKenney, Mark, Elkbuli, Adel, Gosain, Ankush, Abdelsattar, Zaid M, Naunheim, Matthew R, Burks, Ciersten A, Zhou, Allen S, Heng, Marilyn, Abohashem, Shady, Lozano-Calderón, Santiago A, Reisenauer, Janani S, Mouawad, Nicolas J, Diehl, Thomas M, Eriksson, Evert A, Marwaha, Jayson S, Schroeppel, Thomas J, LaRocca, Christopher J, Chang, Grace H, Hassan, Romana, Nosanov, Lauren B, Rickard, Jennifer L, Avraham, Jacob B, Petrone, Patrizio, Sferra, Joseph J, Hadaya, Joseph, Mead, Brittany S, Hauptman, Jason S, Ahmad, Maleeha, Meola, Antonio, Chang, Steven D, Ko, Ara, Specht, Katherine E, Choudhry, Asad, Encalada, Ronald Zerna, Poggio, Juan L, Xing, Hang, Glass, Nina E, Hooker, Robert, Martins, Paulo N, Scott, Erin M, Bankhead, Brittany K, Giorgakis, Emmanouil, Nigh, Joe, Osborn, Tamara, Tay Lasso, Erika L, Beswick, Daniel M, Berndtson, Allison E, Kaups, Krista L, Chen, Lee-lynn, Farrell, Michael S, Boeck, Marissa A, Vaysburg, Dennis M, Kassam, Al-Faraaz, Turner, Kevin M, Dyas, Adam R, Coleman, Julia R, Folsom, Megan, Lam, Christopher M, Kumer, Sean C, Larson, Kelsey, Turner, Scott, Guidry, Christopher, Reddy, Madhuri, Berbel, German, Findley, Austin, Beahm, David, Bur, Andres, Marlor, Derek, Houndschell, Corey, Carver, Shea, Ulrich, Alissa, Bhutiani, Neal, DiChiacchio, Laura, Abdou, Hossam, Napolitano, Lena M, Ghebre, Rahel, Bass, Gary Alan, Kaplan, Lewis J, Martin, Niels D, Duffy, Caoimhe C, Abdelhamid, Sultan S, Daley, Brian J, Roland, Christina L, Dumas, Ryan P, Ban, Vin Shen, Rajesh, Aashish, Davies, Mark G, Purudappa, Prabhudev P, Walters, Camila B, Lin, Nicole, Ruzgar, Nensi M, Ullrich, Sarah J, Trostchansky, Ivan, Bonilla-Cal, Fernando, Castedo, Fabiola, Sobrero, Helena, Acuña, Gastón, Álvarez, Sofía M, Tarigo, Josefina, Carbajal, Ana C, Carbajal, Ana, Reyes, Antonio R, Al-Eryani, Fatima A, Alqousi, Nardeen N, Alattas, Zainab, Al-Saban, Rafat A, Al-Shehari, Mohammed M, ALHammadi, Nawal T, Shream, Sarah A, Al-Naggar, Hamza M, Al-Qalisi, Lina M, Nadeesh, Areej E, Al-Samawi, Hytham H, Bajjah, Hadeel M, AL-Ameri, Saba A, Albably, Jamal F, Ghannam, Rana A, Shamsan, Amatallah H, Meead, Abdullah A, Al- Zubaidi, Riham Q, Zulait, Mohammed A, Najeeb, Halah, Alsayadi, Musaed M, Al-Mashreqi, Seham K, Al-Jomai, Najla A, Alsayadi, Ramzi A, Al-Naggar, Moath M, Almarashi, Hassan A, Musaeed, Hasna M, Al-Raimi, Ibrahim M, Ghanem, Hossam N, Al-Zazay, Karim A, AL-Mahdi, Shehab A, Almontaser, Amatalaleem S, Savopoulos, Vanessa A S, Munthali, James, Kabongo, Kizito M C, Mushiwokufa, Willard, Ngulube, Allan, Ntoto, Crispin, Magama, Praise T, Dzinotyiwei, Daniel, Chivanga, Shelton K, Dube, Ngqabutho S, Sanchez, Ernesto C, Moyo, Assel T, Chengahomwe, Antony, Chinyowa, Simbarashe, Siamuchembu, Maphios, Bondera, Tafadzwa, and Mushawarima, Trust
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- 2022
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5. Terminology for cone dimensions after local conservative treatment for cervical intraepithelial neoplasia and early invasive cervical cancer: 2022 consensus recommendations from ESGO, EFC, IFCPC, and ESP
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Kyrgiou, Maria, Athanasiou, Antonios, Arbyn, Marc, Lax, Sigurd F, Raspollini, Maria Rosaria, Nieminen, Pekka, Carcopino, Xavier, Bornstein, Jacob, Gultekin, Murat, and Paraskevaidis, Evangelos
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- 2022
- Full Text
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6. Accuracy and effectiveness of HPV mRNA testing in cervical cancer screening: a systematic review and meta-analysis
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Arbyn, Marc, Simon, Marie, de Sanjosé, Silvia, Clarke, Megan A, Poljak, Mario, Rezhake, Remila, Berkhof, Johannes, Nyaga, Victoria, Gultekin, Murat, Canfell, Karen, and Wentzensen, Nicolas
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- 2022
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7. Impact of adjuvant treatments and risk factors on survival in 2023 FIGO stage IIB endometrial cancer patients: Turkish Gynecologic Oncology Group Study
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Akgör, Utku, primary, Basaran, Derman, additional, Meydanli, Mehmet Mutlu, additional, Kuscu, Esra, additional, Demirkiran, Fuat, additional, Topuz, Samet, additional, Sancı, Muzaffer, additional, Akbayır, Ozgur, additional, Gultekin, Murat, additional, Salihoglu, Mehmet Yavuz, additional, Akilli, Huseyin, additional, Bese, Tugan, additional, Fırat, Zeliha, additional, Sozen, Hamdullah, additional, Ozgul, Nejat, additional, and Ayhan, Ali, additional
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- 2024
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- View/download PDF
8. COVID-19 infection presented as severe dyskinesia in a patient with Parkinson’s disease: a case with daily video recording
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Gultekin, Murat and Tufekcioglu, Zeynep
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- 2022
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9. Varied phenotypic spectrum presenting of paroxysmal exercise–induced dyskinesia: a Turkish family with SLC2A1 mutation
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Gultekin, Murat, Dogan, Muhammet Ensar, Simsir, Gulsah, and Basak, Ayse Nazlı
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- 2021
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10. 2020 list of human papillomavirus assays suitable for primary cervical cancer screening
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Arbyn, Marc, Simon, Marie, Peeters, Eliana, Xu, Lan, Meijer, Chris J.L.M., Berkhof, Johannes, Cuschieri, Kate, Bonde, Jesper, Ostrbenk Vanlencak, Anja, Zhao, Fang-Hui, Rezhake, Remila, Gultekin, Murat, Dillner, Joakim, de Sanjosé, Silvia, Canfell, Karen, Hillemanns, Peter, Almonte, Maribel, Wentzensen, Nicolas, and Poljak, Mario
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- 2021
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11. Neuroendocrine carcinoma of the endometrium: A very rare gynecologic malignancy
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Akgor, Utku, Kuru, Oguzhan, Sakinci, Mehmet, Boyraz, Gokhan, Sen, Serhat, Cakır, Ilker, Turan, Taner, Gokcu, Mehmet, Gultekin, Murat, Sayhan, Sevil, Salman, Coskun, and Ozgul, Nejat
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- 2021
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12. Adnexal masses in patients with colorectal cancer
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Akgor, Utku, Kuru, Oguzhan, Soyak, Burcu, Gunes, Ali Can, Uyanık, Esra, Gultekin, Murat, Ozgul, Nejat, and Salman, Coskun
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- 2021
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13. Anxiety, depression and concerns of pregnant women during the COVID-19 pandemic
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Akgor, Utku, Fadıloglu, Erdem, Soyak, Burcu, Unal, Canan, Cagan, Murat, Temiz, B. Esat, Erzenoglu, B. Emre, Ak, Sertac, Gultekin, Murat, and Ozyuncu, Ozgur
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- 2021
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14. Criteria for second generation comparator tests in validation of novel HPV DNA tests for use in cervical cancer screening
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MMB, MMB Medische Staf, Infection & Immunity, Arbyn, Marc, Cuschieri, Kate, Bonde, Jesper, Schuurman, Rob, Cocuzza, Clementina, Broeck, Davy Vanden, Zhao, Fang Hui, Rezhake, Remila, Gultekin, Murat, de Sanjosé, Silvia, Canfell, Karen, Hawkes, David, Saville, Marion, Hillemanns, Peter, Dillner, Joakim, Berkhof, Johannes, Prétet, Jean Luc, Gheit, Tarik, Clifford, Gary, Basu, Partha, Almonte, Maribel, Wentzensen, Nicolas, Poljak, Mario, MMB, MMB Medische Staf, Infection & Immunity, Arbyn, Marc, Cuschieri, Kate, Bonde, Jesper, Schuurman, Rob, Cocuzza, Clementina, Broeck, Davy Vanden, Zhao, Fang Hui, Rezhake, Remila, Gultekin, Murat, de Sanjosé, Silvia, Canfell, Karen, Hawkes, David, Saville, Marion, Hillemanns, Peter, Dillner, Joakim, Berkhof, Johannes, Prétet, Jean Luc, Gheit, Tarik, Clifford, Gary, Basu, Partha, Almonte, Maribel, Wentzensen, Nicolas, and Poljak, Mario
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- 2024
15. Criteria for second generation comparator tests in validation of novel HPV DNA tests for use in cervical cancer screening
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Arbyn, M, Cuschieri, K, Bonde, J, Schuurman, R, Cocuzza, C, Broeck, D, Zhao, F, Rezhake, R, Gultekin, M, de Sanjosé, S, Canfell, K, Hawkes, D, Saville, M, Hillemanns, P, Dillner, J, Berkhof, J, Prétet, J, Gheit, T, Clifford, G, Basu, P, Almonte, M, Wentzensen, N, Poljak, M, Arbyn, Marc, Cuschieri, Kate, Bonde, Jesper, Schuurman, Rob, Cocuzza, Clementina, Broeck, Davy Vanden, Zhao, Fang‐Hui, Rezhake, Remila, Gultekin, Murat, de Sanjosé, Silvia, Canfell, Karen, Hawkes, David, Saville, Marion, Hillemanns, Peter, Dillner, Joakim, Berkhof, Johannes, Prétet, Jean‐Luc, Gheit, Tarik, Clifford, Gary, Basu, Partha, Almonte, Maribel, Wentzensen, Nicolas, Poljak, Mario, Arbyn, M, Cuschieri, K, Bonde, J, Schuurman, R, Cocuzza, C, Broeck, D, Zhao, F, Rezhake, R, Gultekin, M, de Sanjosé, S, Canfell, K, Hawkes, D, Saville, M, Hillemanns, P, Dillner, J, Berkhof, J, Prétet, J, Gheit, T, Clifford, G, Basu, P, Almonte, M, Wentzensen, N, Poljak, M, Arbyn, Marc, Cuschieri, Kate, Bonde, Jesper, Schuurman, Rob, Cocuzza, Clementina, Broeck, Davy Vanden, Zhao, Fang‐Hui, Rezhake, Remila, Gultekin, Murat, de Sanjosé, Silvia, Canfell, Karen, Hawkes, David, Saville, Marion, Hillemanns, Peter, Dillner, Joakim, Berkhof, Johannes, Prétet, Jean‐Luc, Gheit, Tarik, Clifford, Gary, Basu, Partha, Almonte, Maribel, Wentzensen, Nicolas, and Poljak, Mario
- Abstract
While HC2 and GP5+/6+ PCR-EIA were pivotal in test validation of new HPV assays, they represent the first generation of comparator tests based upon technologies that are not in widespread use anymore. In the current guideline, criteria for second-generation comparator tests are presented that include more detailed resolution of HPV genotypes. Second-generation comparator tests should preferentially target only the 12 genotypes classified as carcinogenic (IARC-group I), and show consistent non-inferior sensitivity for CIN2+ and CIN3+ and specificity for ≤CIN1 compared to one of the first-generations comparators, in at least three validation studies using benchmarks of 0.95 for relative sensitivity and 0.98 for relative specificity. Validation should take into account used storage media and other sample handling procedures. Meta-analyses were conducted to identify the assays that fulfill these stringent criteria. Four tests fulfilled the new criteria: (1) RealTime High-Risk HPV Test (Abbott), (2) Cobas-4800 HPV test (Roche Molecular System), (3) Onclarity HPV Assay (BD Diagnostics), and (4) Anyplex II HPV HR Detection (Seegene), each evaluated in three to six studies. Whereas the four assays target 14 carcinogenic genotypes, the first two identify separately HPV16 and 18, the third assay identifies five types separately and the fourth identifies all the types separately.
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- 2024
16. Criteria for second generation comparator tests in validation of novel HPV DNA tests for use in cervical cancer screening.
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Arbyn, Marc, Cuschieri, Kate, Bonde, Jesper, Schuurman, Rob, Cocuzza, Clementina, Broeck, Davy Vanden, Zhao, Fang‐Hui, Rezhake, Remila, Gultekin, Murat, de Sanjosé, Silvia, Canfell, Karen, Hawkes, David, Saville, Marion, Hillemanns, Peter, Dillner, Joakim, Berkhof, Johannes, Prétet, Jean‐Luc, Gheit, Tarik, Clifford, Gary, and Basu, Partha
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EARLY detection of cancer ,HUMAN papillomavirus ,SAMPLING (Process) ,CERVICAL cancer ,COMPARATOR circuits - Abstract
While HC2 and GP5+/6+ PCR‐EIA were pivotal in test validation of new HPV assays, they represent the first generation of comparator tests based upon technologies that are not in widespread use anymore. In the current guideline, criteria for second‐generation comparator tests are presented that include more detailed resolution of HPV genotypes. Second‐generation comparator tests should preferentially target only the 12 genotypes classified as carcinogenic (IARC‐group I), and show consistent non‐inferior sensitivity for CIN2+ and CIN3+ and specificity for ≤CIN1 compared to one of the first‐generations comparators, in at least three validation studies using benchmarks of 0.95 for relative sensitivity and 0.98 for relative specificity. Validation should take into account used storage media and other sample handling procedures. Meta‐analyses were conducted to identify the assays that fulfill these stringent criteria. Four tests fulfilled the new criteria: (1) RealTime High‐Risk HPV Test (Abbott), (2) Cobas‐4800 HPV test (Roche Molecular System), (3) Onclarity HPV Assay (BD Diagnostics), and (4) Anyplex II HPV HR Detection (Seegene), each evaluated in three to six studies. Whereas the four assays target 14 carcinogenic genotypes, the first two identify separately HPV16 and 18, the third assay identifies five types separately and the fourth identifies all the types separately. [ABSTRACT FROM AUTHOR]
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- 2024
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17. Evaluation of Endocervical Curettage in Colposcopy in the Turkish Cervical Cancer Screening Program.
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Akgor, Utku, Ozgul, Nejat, Gunes, Ali Can, Turkyılmaz, Murat, and Gultekin, Murat
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HUMAN papillomavirus ,EARLY detection of cancer ,CERVICAL cancer ,COLPOSCOPY ,CURETTAGE ,CERVICAL intraepithelial neoplasia - Abstract
Background/Objectives: To investigate the risk factors for CIN2+ lesions (cervical intraepithelial neoplasia 3 or worse) in endocervical curettage (ECC) and to evaluate the relationship between the addition of ECC to punch biopsy in terms of the yield of CIN2+ lesions. Methods: Between February 2018 and 2019, data on colposcopy results from 11,944 patients were gathered from the Cancer Department of the Turkish Ministry of Health across the country. A total of 6370 women whom were referred to colposcopy were included in this study. Risk factors were identified using both univariate and multivariate logistic analyses. Results: The median age was 42 years old (range, 30–65). ASC-H (atypical squamous cells-suggestive of high-grade squamous intraepithelial lesion)/HSIL (high-grade intraepithelial lesion) cytology (OR 7.648 95% CI (3.933–14.871)) and HPV (human papillomavirus)-16/18 infection (OR 2.541 95% CI (1.788–3.611)) were identified as risk factors for having CIN2+ lesions. CIN2+ diagnostic yield by ECC is only 1.2% all patients. CIN2+ diagnostic yield by punch biopsy and ECC are 9.7% and 6% of patients, respectively. A higher CIN2+ yield by ECC was observed with increasing age. Among cytology groups, ASC-H/HSIL has highest CIN2+ yield by ECC. Finally, in patients with incomplete visualization of the squamocolumnar junction (SCJ), ECC yields approximately twice as many CIN2+ lesions. Conclusions: ECC should be considered in cases of advanced patient age and in situations where the SCJ is not routinely visualized. In addition, evaluation of the endocervical canal is necessary in HPV-positive cases infected with HPV-16/18 types and in cases infected with HPV of any type but with cytological abnormalities. [ABSTRACT FROM AUTHOR]
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- 2024
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18. How to triage HPV positive cases: Results of four million females
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Gultekin, Murat, Dundar, Selin, Keskinkilic, Bekir, Turkyilmaz, Murat, Ozgul, Nejat, Yuce, Kunter, and Kara, Fatih
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- 2020
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19. The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD) and the European Federation for Colposcopy (EFC) consensus statements on pre-invasive vulvar lesions
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Preti, Mario, Joura, Elmar, Vieira-Baptista, Pedro, Van Beurden, Marc, Bevilacqua, Federica, Bleeker, Maaike C G, Bornstein, Jacob, Carcopino, Xavier, Chargari, Cyrus, Cruickshank, Margaret E, Erzeneoglu, Bilal Emre, Gallio, Niccolò, Heller, Debra, Kesic, Vesna, Reich, Olaf, Stockdale, Colleen K, Temiz, Bilal Esat, Woelber, Linn, Planchamp, François, Zodzika, Jana, Querleu, Denis, and Gultekin, Murat
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- 2022
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20. Lymph node dissection in intermediate and high-intermediate risk endometrial cancer
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akgör, utku, primary, salman, coskun, additional, Ozgul, Nejat, additional, and Gultekin, Murat, additional
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- 2024
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21. Cervical screening: ESGO-EFC position paper of the European Society of Gynaecologic Oncology (ESGO) and the European Federation of Colposcopy (EFC)
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Kyrgiou, Maria, Arbyn, Marc, Bergeron, Christine, Bosch, F. Xavier, Dillner, Joakim, Jit, Mark, Kim, Jane, Poljak, Mario, Nieminen, Pekka, Sasieni, Peter, Kesic, Vesna, Cuzick, Jack, and Gultekin, Murat
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- 2020
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22. Sarcopenia, dynapenia, and body composition in Parkinson’s disease: are they good predictors of disability?: a case–control study
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Ozer, Firuzan Fırat, Akın, Sibel, Gultekin, Murat, and Zararsız, Gozde Erturk
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- 2020
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23. Human papillomavirus vaccination: The ESGO–EFC position paper of the European society of Gynaecologic Oncology and the European Federation for colposcopy
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Joura, Elmar A., Kyrgiou, Maria, Bosch, Francisco X., Kesic, Vesna, Niemenen, Pekka, Redman, Charles WE., and Gultekin, Murat
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- 2019
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24. Mega Hpv laboratories for cervical cancer control: Challenges and recommendations from a case study of Turkey
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Gultekin, Murat, Karaca, Mujdegul Zayifoglu, Kucukyildiz, Irem, Dundar, Selin, Keskinkilic, Bekir, and Turkyilmaz, Murat
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- 2019
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25. Primary vs. interval cytoreduction for high-grade serous ovarian cancer: oncological outcomes from a retrospective study at a single tertiary referral center.
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Zaim, Onur Can, Ozgul, Nejat, Salman, Mehmet Coskun, Ege, Hasan Volkan, Basaran, Derman, Geredelioglu, Yakup, and Gultekin, Murat
- Abstract
High-grade serous carcinomas are the most prevalent subtype of ovarian cancer. While primary debulking surgery (PDS) remains as standard approach, neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS) is an alternative for certain patients. Our study aims to compare the oncological outcomes of these strategies in our clinic. Our retrospective study involves the patients diagnosed with advanced stage high-grade serous ovarian cancer (HGSOC) at Hacettepe University Gynecologic Oncology Clinic from January 2014 to May 2021. Patients were categorized into two groups: PDS group and NACT/IDS group. We conducted a comparison between these groups, analyzing patient characteristics, staging and subsequent oncological followup outcomes. A total of 151 patients were enrolled in study population, with the PDS group consisting of 77 patients whereas the NACT/IDS group 74. The median followup period of our study was determined as 45 months. The median overall survival (OS) of the study population was determined to be 54 months, and the median progressionfree survival (PFS) was 11 months. Accordingly, our study involved an attempt to identify independent variables that may have an impact on OS and PFS. Multivariate analysis confirmed that achieving "no residual tumor after surgery" directly influences OS rates (Hazard Ratio (HR): 0.57 (95% Confidence Interval (CI) 0.34-0.96); p = 0.034). Regarding overall survival (HR: 0.74 (95% CI 0.45-1.22); log rank p = 0.234) and progression-free survival (HR: 0.728 (95% CI 0.50-1.06); log rank p = 0.083), it was demonstrated that both strategies yield comparable oncological outcomes. Furthermore, the impact of pandemic on the preference of treatment strategy has also been evaluated. NACT/IDS and PDS strategies have comparable oncological outcomes, in terms of surgical complications, recurrence and survival rates. However, if it is envisaged that no residual disease after surgery with appropriate patient selection, PDS strategy can be considered as leading option. [ABSTRACT FROM AUTHOR]
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- 2024
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26. DTI Measurements for Huntington Disease Using Mricloud.
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Arslan, Ayla, Nisari, Mehtap, Guler, Emel, Uzun, Gokce Bagci, Gultekin, Murat, Donmez, Halil, Bagci, Keziban, and Acer, Niyazi
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BRAIN ,OCCIPITAL lobe ,MAGNETIC resonance imaging ,NEURODEGENERATION ,DESCRIPTIVE statistics ,FRONTOTEMPORAL lobar degeneration ,LIMBIC system ,FRONTAL lobe ,DIGITAL image processing ,COMPARATIVE studies ,INFLAMMATION ,DATA analysis software ,PARIETAL lobe ,HUNTINGTON disease - Abstract
Aim: Neurodegenerative diseases are important health problems that affect many people. In this study, it was aimed to examine the brain regions of Huntington's patients by performing brain parcellation. Material and Method: 8 controls and 8 Huntington's patients participated in the study. We measured four Diffusion Tensor Imaging metrics which were axial diffusivity, mean diffusivity, radial diffusivity and fractional anisotropy performing brain parcellation over Diffusion Tensor Imaging for control and patient groups. We used a full automated data-driven approach to study the whole brain, divided in regions of interest using mricloud. Results: When the huntington disease group compared to control group, We found that mean diffusivity and axial diffusivity increased frontal, parietal, temporal, occipital, corpus callosum, white matter, limbic and subcortical structures, and radial diffusivity increased corpus callosum, capsula interna (p<0.05). The fractional anisotropy value was higher in nucleus caudatus, putamen and a significant difference was observed (p<0.05). Conclusion: The increase of axial diffusivity and mean diffusivity values axonal degeneration and demyelination of frontal, parietal, temporal, occipital, corpus callosum, white matter, limbic, subcortical structures; increased radial diffusivity values dysmyelination of the corpus callosum and capsula interna; fractional anisotropy increased values in nucleus caudatus and putamen may indicate a degenerative process, axon loss and inflammation. [ABSTRACT FROM AUTHOR]
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- 2024
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27. Lower Limb Lymphedema Awareness among Gynecological Cancer Patients: An International Survey Supported by the European Network of Gynecological Cancer Advocacy Groups (ENGAGe) Group.
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Haidopoulos, Dimitrios, Pergialiotis, Vasilios, Papageorgiou, Maria, Halaska, Michael J., Maxova, Katerina, Ulrich, Elena, Zapardiel, Ignacio, Rodolakis, Alexandros, Gultekin, Murat, and Fotopoulou, Christina
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LEG physiology ,LYMPHEDEMA ,RISK assessment ,HEALTH literacy ,DISEASE management ,QUESTIONNAIRES ,CANCER patients ,PATIENT advocacy ,DESCRIPTIVE statistics ,GYNECOLOGY ,FEMALE reproductive organ tumors ,SURVEYS ,SURGICAL complications ,QUALITY of life ,COUNSELING ,DISEASE risk factors - Abstract
Simple Summary: Patient awareness of postoperative lymphedema has been poorly explored in gynecologic oncology. While current research has extensively focused on the impact of pelvic and paraortic lymphadenectomy on patient survival, it remains relatively unknown how much of this information is actually discussed with patients that undergo surgery or radiation therapy for the treatment of their disease. In the present study we present information relevant to lymphedema awareness provided by 386 gynecological cancer patients that were treated for gynecologic malignancy. A significant lack of appropriate counseling was noted that seems to be driven by lack of appropriate physician training. This information calls for further research that will help improve patient counseling and pre-treatment decision making. Introduction: Patient awareness of postoperative lymphedema in the field of gynecologic oncology has been poorly documented in the international literature. We wished to capture and document the awareness among gynecological cancer survivors about postoperative lymphedema, including aspects such as the adequacy of perioperative counseling, management, and quality of life. Methods: A web-based survey comprising 25 multiple-choice questions was distributed to gynecological cancer advocacy groups within the European Network of Gynecological Cancer Advocacy Groups (ENGAGe) group. The survey was validated in a pilot group of gynecological patients prior to distribution. Results: Overall, 386 women from 20 countries completed the questionnaire. Only half of the patients (n = 211) knew what lymphedema is, whereas 52% of the respondents stated that they were never informed at their pre-operative assessment about the potential risk of developing lymphedema. Fifty-three percent of those women who were informed about the risk and management of lymphedema received information through self-initiative, connecting mainly with patient groups or online. Approximately 84% of patients with lymphedema reported that they informed their doctor about their symptoms. Ninety-four patients (55.3%, which is not 55% of the 386) were treated for lymphedema. Forty-five women out of 136 reported that lymphedema significantly affected their everyday lives. Discussion: We report a large lack of awareness and a significant gap of knowledge about the risks and treatment options related to postoperative lymphedema among gynecological cancer survivors. Institutional practice routines and awareness among professionals need to be urgently recalled and adapted to adequately inform and support gynecological cancer patients. [ABSTRACT FROM AUTHOR]
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- 2024
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28. Highlights from the 24th European Congress on Gynaecological Oncology in Istanbul: an ENYGO-IJGC Fellows compilation
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Angeles, Martina Aida, primary, De Vitis, Luigi Antonio, additional, Cucinella, Giuseppe, additional, Bonaldo, Giulio, additional, Bizzarri, Nicolò, additional, Agusti, Nuria, additional, Kacperczyk-Bartnik, Joanna, additional, El Hajj, Houssein, additional, Theofanakis, Charalampos, additional, Bilir, Esra, additional, Hsu, Heng-Cheng, additional, Estrada, Erick Estuardo, additional, Pareja, Rene, additional, Fotopoulou, Christina, additional, du Bois, Andreas, additional, Plante, Marie, additional, Rauh-Hain, Jose Alejandro, additional, Mirza, Mansoor Raza, additional, Monk, Bradley J, additional, Gultekin, Murat, additional, Joura, Elmar, additional, Fagotti, Anna, additional, and Ramirez, Pedro T, additional
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- 2023
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29. Genital tract microbiota composition profiles and use of prebiotics and probiotics in gynaecological cancer prevention: review of the current evidence, the European Society of Gynaecological Oncology prevention committee statement
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Mitra, Anita, primary, Gultekin, Murat, additional, Burney Ellis, Laura, additional, Bizzari, Nicolò, additional, Bowden, Sarah, additional, Taumberger, Nadja, additional, Bracic, Taja, additional, Vieira-Baptista, Pedro, additional, Sehouli, Jalid, additional, and Kyrgiou, Maria, additional
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- 2023
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30. Foreign Accent Syndrome After COVID 19 Infection
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Olguner Eker, Ozlem, primary, Gultekin, Murat, additional, and Demirel Ozsoy, Saliha, additional
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- 2023
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31. Building research competency across low and middle resource settings: an ENGOT initiative and NOGGO mentorship program at the ESGO 2022 in Berlin
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Nasser, Sara, primary, Bilir, Esra, additional, David, Atallah, additional, Gultekin, Murat, additional, and Sehouli, Jalid, additional
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- 2023
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32. Evaluation of colposcopy after the addition of human papillomavirus testing to the Turkish cervical cancer screening program
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Gunes, Ali Can, primary, Ozgul, Nejat, additional, Turkyılmaz, Murat, additional, Kara, Fatih, additional, Unlu, Fahriye, additional, Ayhan, Ali, additional, and Gultekin, Murat, additional
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- 2023
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33. EP346/#1537 Investigating vulvar lichen sclerosus and high-risk oncogenic HPV association
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Erzeneoglu, Bilal Emre, primary, Temiz, Bilal Esat, additional, Ege, Volkan, additional, Basaran, Derman, additional, Gultekin, Murat, additional, and Ozgul, Nejat, additional
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- 2023
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34. PTPA variants and impaired PP2A activity in early-onset parkinsonism with intellectual disability
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Fevga, Christina, Tesson, Christelle, Carreras Mascaro, Ana, Courtin, Thomas, Van Coller, Riaan, Sakka, Salma, Ferraro, Federico, Farhat, Nouha, Bardien, Soraya, Damak, Mariem, Carr, Jonathan, Ferrien, Melanie, Boumeester, Valerie, Hundscheid, Jasmijn, Grillenzoni, Nicola, Kessissoglou, Irini A., Kuipers, Demy J.S., Quadri, Marialuisa, Agid, Yves, Anheim, Mathieu, Borg, Michel, Brice, Alexis, Broussolle, Emmanuel, Corvol, Jean Christophe, Damier, Philippe, Defebvre, Luc, Dürr, Alexandra, Durif, Franck, Houeto, Jean Luc, Krack, Paul, Klebe, Stephan, Lesage, Suzanne, Lohmann, Ebba, Martinez, Maria, Mangone, Graziella, Mariani, Louise Laure, Pollak, Pierre, Rascol, Olivier, Tison, François, Tranchant, Christine, Verin, Marc, Viallet, François, Vidailhet, Marie, Emre, Murat, Hanagasi, Hasmet, Bilgic, Basar, Lu, Bedia Marangozog, Benmahdjoub, Mustapha, Arezki, Mohammed, Bouchetara, Sofiane A., Benhassine, Traki, Tazir, Meriem, Djebara, Mouna Ben, Gouider, Riadh, Romdhan, Sawssan Ben, Mhiri, Chokri, Bouhouche, Ahmed, Bonifati, Vincenzo, Mandemakers, Wim, Kievit, Anneke J.A., Boon, Agnita J.W., Ferreira, Joaquim J., Guedes, Leonor Correia, Hanagasi, Hasmet A., Tufekcioglu, Zeynep, Elibol, Bulent, Dog.u, Okan, Gultekin, Murat, Chien, Hsin F., Barbosa, Egberto, Jardim, Laura Bannach, Rieder, Carlos R.M., Chang, Hsiu Chen, Lu, Chin Song, Wu-Chou, Yah Huei, Yeh, Tu Hsueh, Lopiano, Leonardo, Tassorelli, Cristina, Pacchetti, Claudio, Comi, Cristoforo, Raudino, Francesco, Bertolasi, Laura, Tinazzi, Michele, Bonizzato, Alberto, Ferracci, Carlo, Marconi, Roberto, Guidi, Marco, Onofrj, Marco, Thomas, Astrid, Vanacore, Nicola, Meco, Giuseppe, Fabrizio, Edito, Fabbrini, Giovanni, Berardelli, Alfredo, Stocchi, Fabrizio, Vacca, Laura, Barone, Paolo, Picillo, Marina, De Michele, Giuseppe, Criscuolo, Chiara, De Mari, Michele, Dell'aquila, Claudia, Iliceto, Giovanni, Toni, Vincenzo, Trianni, Giorgio, Saddi, Valeria, Cossu, Gianni, Melis, Maurizio, Hassan, Bassem A., Breedveld, Guido J., Erasmus University Medical Center [Rotterdam] (Erasmus MC), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Service de Génétique médicale [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Faculty of Health Sciences [Pretoria], University of Pretoria [South Africa], Hopital Habib Bourguiba - Habib Bourguiba Hospital [Sfax], Stellenbosch University, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Motivation, cerveau et comportement = Motivation, Brain and Behavior [ICM Paris] (MBB), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Tesson, Christelle, Clinical Genetics, and Neurology
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[SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics ,intellectual disability ,PTPA ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,PPP2R4 ,[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Neurology (clinical) ,[SDV.GEN.GH] Life Sciences [q-bio]/Genetics/Human genetics ,parkinsonism ,PP2A - Abstract
The protein phosphatase 2A complex (PP2A), the major Ser/Thr phosphatase in the brain, is involved in a number of signalling pathways and functions, including the regulation of crucial proteins for neurodegeneration, such as alpha-synuclein, tau and LRRK2. Here, we report the identification of variants in the PTPA/PPP2R4 gene, encoding a major PP2A activator, in two families with early-onset parkinsonism and intellectual disability. We carried out clinical studies and genetic analyses, including genome-wide linkage analysis, whole-exome sequencing, and Sanger sequencing of candidate variants. We next performed functional studies on the disease-associated variants in cultured cells and knock-down of ptpa in Drosophila melanogaster. We first identified a homozygous PTPA variant, c.893T>G (p.Met298Arg), in patients from a South African family with early-onset parkinsonism and intellectual disability. Screening of a large series of additional families yielded a second homozygous variant, c.512C>A (p.Ala171Asp), in a Libyan family with a similar phenotype. Both variants co-segregate with disease in the respective families. The affected subjects display juvenile-onset parkinsonism and intellectual disability. The motor symptoms were responsive to treatment with levodopa and deep brain stimulation of the subthalamic nucleus. In overexpression studies, both the PTPA p.Ala171Asp and p.Met298Arg variants were associated with decreased PTPA RNA stability and decreased PTPA protein levels; the p.Ala171Asp variant additionally displayed decreased PTPA protein stability. Crucially, expression of both variants was associated with decreased PP2A complex levels and impaired PP2A phosphatase activation. PTPA orthologue knock-down in Drosophila neurons induced a significant impairment of locomotion in the climbing test. This defect was age-dependent and fully reversed by L-DOPA treatment. We conclude that bi-allelic missense PTPA variants associated with impaired activation of the PP2A phosphatase cause autosomal recessive early-onset parkinsonism with intellectual disability. Our findings might also provide new insights for understanding the role of the PP2A complex in the pathogenesis of more common forms of neurodegeneration.
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- 2023
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35. Centralization of mammography reporting with mobile trucks: Turkish experience
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Gultekin, Murat, Ozturk, Cansu, Karaca, Serdar, Boztaş, Güledal, Turan, Semra Hatice, Dundar, Selin, Hacikamiloglu, Ezgi, Araz, Levent, Murtuza, Kamil, and Keskinkilic, Bekir
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- 2018
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36. Retinal vessel diameter obtained by optical coherence tomography is spared in Parkinson’s disease
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Gulmez Sevim, Duygu, Unlu, Metin, Sonmez, Serap, Gultekin, Murat, Karaca, Cagatay, and Ozturk Oner, Ayse
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- 2019
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37. Retinal single-layer analysis with optical coherence tomography shows inner retinal layer thinning in Huntington’s disease as a potential biomarker
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Gulmez Sevim, Duygu, Unlu, Metin, Gultekin, Murat, and Karaca, Cagatay
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- 2019
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38. #791 The need for vulvar biopsy in women with chronic itching: a single-center study
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Erzeneoglu, Bilal Emre, primary, Temiz, Bilal Esat, additional, Basaran, Derman, additional, Ege, Hasan Volkan, additional, Atakul, Muhammet Onur, additional, Yavuz, Ömer Alp, additional, and Gultekin, Murat, additional
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- 2023
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39. #696 The role of office hysteroscopy in symptomatic or asymptomatic patients in the postmenopausal period
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Esat Temi?z, Bilal, primary, Erzeneoglu, Bilal Emre, additional, Cabukoglu, Fatma Caner, additional, Akdeni?Z, Eylül, additional, Ege, Hasan Volkan, additional, Basaran, Derman, additional, Ozgul, Nejat, additional, and Gultekin, Murat, additional
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- 2023
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40. #798 Is the tumor size effective for lymphadenectomy decision in early-stage endometrial cancer?
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Artiran, Nüseybe, primary, Kamani, Mustafa Onur, additional, Sinci, Umut, additional, Ege, Hasan Volkan, additional, Özgül, Nejat, additional, and Gultekin, Murat, additional
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- 2023
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41. #792 Our single-center experience with colposcopy in cases of postcoital bleeding
- Author
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Ege, Hasan Volkan, primary, Güngör, Betül, additional, Discioglu, Neslihan, additional, Özgül, Nejat, additional, Basaran, Derman, additional, and Gultekin, Murat, additional
- Published
- 2023
- Full Text
- View/download PDF
42. #991 Evaluation of clinical and pathological data of patients with endometrium cancer with microsatellit instability
- Author
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Sahna, Özlem Celik, primary, Ege, Hasan Volkan, additional, Salman, Mehmet Coskun, additional, Gultekin, Murat, additional, Akgör, Utku, additional, and Özgül, Nejat, additional
- Published
- 2023
- Full Text
- View/download PDF
43. Retroperitoneal nodal metastasis in primary adult type granulosa cell tumor of the ovary: Can routine lymphadenectomy be omitted?
- Author
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Kuru, Oguzhan, Boyraz, Gokhan, Uckan, Hasan, Erturk, Anıl, Gultekin, Murat, Ozgul, Nejat, Salman, Coskun, and Yuce, Kunter
- Published
- 2017
- Full Text
- View/download PDF
44. The p.Thr11Met mutation in c19orf12 is frequent among adult Turkish patients with MPAN
- Author
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Olgiati, Simone, Doğu, Okan, Tufekcioglu, Zeynep, Diler, Yunus, Saka, Esen, Gultekin, Murat, Kaleagasi, Hakan, Kuipers, Demy, Graafland, Josja, Breedveld, Guido J., Quadri, Marialuisa, Sürmeli, Reyhan, Sünter, Gülin, Doğan, Tuğrul, Yalçın, Ayşe Destina, Bilgiç, Başar, Elibol, Bülent, Emre, Murat, Hanagasi, Hasmet A., and Bonifati, Vincenzo
- Published
- 2017
- Full Text
- View/download PDF
45. Clinical and genetic features of PKAN patients in a tertiary centre in Turkey
- Author
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Akcakaya, Nihan Hande, Iseri, Sibel Ugur, Bilir, Birdal, Battaloglu, Esra, Tekturk, Pinar, Gultekin, Murat, Akar, Gokcen, Yigiter, Remzi, Hanagasi, Hasmet, Alp, Recep, Cagirici, Sultan, Eraksoy, Mefkure, Ozbek, Ugur, and Yapici, Zuhal
- Published
- 2017
- Full Text
- View/download PDF
46. Highlights from the 24th European Congress on Gynaecological Oncology in Istanbul: an ENYGO-IJGC Fellows compilation.
- Author
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Aida Angeles, Martina, De Vitis, Luigi Antonio, Cucinella, Giuseppe, Bonaldo, Giulio, Bizzarri, Nicolò, Agusti, Nuria, Kacperczyk-Bartnik, Joanna, El Hajj, Houssein, Theofanakis, Charalampos, Bilir, Esra, Heng-Cheng Hsu, Estuardo Estrada, Erick, Pareja, Rene, Fotopoulou, Christina, du Bois, Andreas, Plante, Marie, Rauh-Hain, Jose Alejandro, Mirza, Mansoor Raza, Monk, Bradley J., and Gultekin, Murat
- Published
- 2024
- Full Text
- View/download PDF
47. Effective approaches towards eliminating cervical cancer from low-and middle-income countries amid COVID-19 pandemic
- Author
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Rahman, Md Sazedur, Gultekin, Murat, and Lassi, Zohra S
- Published
- 2020
- Full Text
- View/download PDF
48. European Federation for Colposcopy (EFC) and European Society of Gynaecological Oncology (ESGO) joint considerations about human papillomavirus (HPV) vaccination, screening programs, colposcopy, and surgery during and after the COVID-19 pandemic
- Author
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Ciavattini, Andrea, Carpini, Giovanni Delli, Giannella, Luca, Arbyn, Marc, Kyrgiou, Maria, Joura, Elmar A, Sehouli, Jalid, Carcopino, Xavier, Redman, Charles W, Nieminen, Pekka, Cruickshank, Maggie, and Gultekin, Murat
- Published
- 2020
- Full Text
- View/download PDF
49. Frontline fighters: the continued fight against COVID-19
- Author
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Akilli, Huseyin, Celik, Husnu, Taskiran, Cagatay, Bilir, Esra, and Gultekin, Murat
- Published
- 2020
- Full Text
- View/download PDF
50. Passion for saving lives: Turkey between 2012 and 2017
- Author
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Gultekin, Murat, Turan, Semra Hatice, Boztas, Guledal, Öztürk, Cansu, and Hacikamiloğlu, Ezgi
- Published
- 2020
- Full Text
- View/download PDF
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