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1. A giant exoplanet orbiting a very low-mass star challenges planet formation models

Author

Morales, J. C., Mustill, A. J., Ribas, I., Davies, M. B., Reiners, A., Bauer, F. F., Kossakowski, D., Herrero, E., Rodríguez, E., López-González, M. J., Rodríguez-López, C., Béjar, V. J. S., González-Cuesta, L., Luque, R., Pallé, E., Perger, M., Baroch, D., Johansen, A., Klahr, H., Mordasini, C., Anglada-Escudé, G., Caballero, J. A., Cortés-Contreras, M., Dreizler, S., Lafarga, M., Nagel, E., Passegger, V. M., Reffert, S., Rosich, A., Schweitzer, A., Tal-Or, L., Trifonov, T., Zechmeister, M., Quirrenbach, A., Amado, P. J., Guenther, E. W., Hagen, H. -J., Henning, T., Jeffers, S. V., Kaminski, A., Kürster, M., Montes, D., Seifert, W., Abellán, F. J., Abril, M., Aceituno, J., Aceituno, F. J., Alonso-Floriano, F. J., Eiff, M. Ammler-von, Antona, R., Arroyo-Torres, B., Azzaro, M., Barrado, D., Becerril-Jarque, S., Benítez, D., Berdiñas, Z. M., Bergond, G., Brinkmöller, M., del Burgo, C., Burn, R., Calvo-Ortega, R., Cano, J., Cárdenas, M. C., Guillén, C. Cardona, Carro, J., Casal, E., Casanova, V., Casasayas-Barris, N., Chaturvedi, P., Cifuentes, C., Claret, A., Colomé, J., Czesla, S., Díez-Alonso, E., Dorda, R., Emsenhuber, A., Fernández, M., Fernández-Martín, A., Ferro, I. M., Fuhrmeister, B., Galadí-Enríquez, D., Cava, I. Gallardo, Vargas, M. L. García, Garcia-Piquer, A., Gesa, L., González-Álvarez, E., Hernández, J. I. González, González-Peinado, R., Guàrdia, J., Guijarro, A., de Guindos, E., Hatzes, A. P., Hauschildt, P. H., Hedrosa, R. P., Hermelo, I., Arabi, R. Hernández, Otero, F. Hernández, Hintz, D., Holgado, G., Huber, A., Huke, P., Johnson, E. N., de Juan, E., Kehr, M., Kemmer, J., Kim, M., Klüter, J., Klutsch, A., Labarga, F., Labiche, N., Lalitha, S., Lampón, M., Lara, L. M., Launhardt, R., Lázaro, F. J., Lizon, J. -L., Llamas, M., Lodieu, N., del Fresno, M. López, Salas, J. F. López, López-Santiago, J., Madinabeitia, H. Magán, Mall, U., Mancini, L., Mandel, H., Marfil, E., Molina, J. A. Marín, Martín, E. L., Martín-Fernández, P., Martín-Ruiz, S., Martínez-Rodríguez, H., Marvin, C. J., Mirabet, E., Moya, A., Naranjo, V., Nelson, R. P., Nortmann, L., Nowak, G., Ofir, A., Pascual, J., Pavlov, A., Pedraz, S., Medialdea, D. Pérez, Pérez-Calpena, A., Perryman, M. A. C., Rabaza, O., Ballesta, A. Ramón, Rebolo, R., Redondo, P., Rix, H. -W., Rodler, F., Trinidad, A. Rodríguez, Sabotta, S., Sadegi, S., Salz, M., Sánchez-Blanco, E., Carrasco, M. A. Sánchez, Sánchez-López, A., Sanz-Forcada, J., Sarkis, P., Sarmiento, L. F., Schäfer, S., Schlecker, M., Schmitt, J. H. M. M., Schöfer, P., Solano, E., Sota, A., Stahl, O., Stock, S., Stuber, T., Stürmer, J., Suárez, J. C., Tabernero, H. M., Tulloch, S. M., Veredas, G., Vico-Linares, J. I., Vilardell, F., Wagner, K., Winkler, J., Wolthoff, V., Yan, F., and Osorio, M. R. Zapatero

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract

Statistical analyses from exoplanet surveys around low-mass stars indicate that super-Earth and Neptune-mass planets are more frequent than gas giants around such stars, in agreement with core accretion theory of planet formation. Using precise radial velocities derived from visual and near-infrared spectra, we report the discovery of a giant planet with a minimum mass of 0.46 Jupiter masses in an eccentric 204-day orbit around the very low-mass star GJ 3512. Dynamical models show that the high eccentricity of the orbit is most likely explained from planet-planet interactions. The reported planetary system challenges current formation theories and puts stringent constraints on the accretion and migration rates of planet formation and evolution models, indicating that disc instability may be more efficient in forming planets than previously thought., Comment: Manuscript author version. 41 pages, 11 figures

Published
2019
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2. The CARMENES search for exoplanets around M dwarfs. Two temperate Earth-mass planet candidates around Teegarden's Star

Author

Zechmeister, M., Dreizler, S., Ribas, I., Reiners, A., Caballero, J. A., Bauer, F. F., Béjar, V. J. S., González-Cuesta, L., Herrero, E., Lalitha, S., López-González, M. J., Luque, R., Morales, J. C., Pallé, E., Rodríguez, E., López, C. Rodríguez, Tal-Or, L., Anglada-Escudé, G., Quirrenbach, A., Amado, P. J., Abril, M., Aceituno, F. J., Aceituno, J., Alonso-Floriano, F. J., Eiff, M. Ammler-von, Jiménez, R. Antona, Anwand-Heerwart, H., Arroyo-Torres, B., Azzaro, M., Baroch, D., Barrado, D., Becerril, S., Benítez, D., Berdiñas, Z. M., Bergond, G., Bluhm, P., Brinkmöller, M., del Burgo, C., Ortega, R. Calvo, Cano, J., Guillén, C. Cardona, Carro, J., Vázquez, M. C. Cárdenas, Casal, E., Casasayas-Barris, N., Casanova, V., Chaturvedi, P., Cifuentes, C., Claret, A., Colomé, J., Cortés-Contreras, M., Czesla, S., Díez-Alonso, E., Dorda, R., Fernández, M., Fernández-Martín, A., Ferro, I. M., Fuhrmeister, B., Fukui, A., Galadí-Enríquez, D., Cava, I. Gallardo, de la Fuente, J. Garcia, Garcia-Piquer, A., Vargas, M. L. García, Gesa, L., Rueda, J. Góngora, González-Álvarez, E., Hernández, J. I. González, González-Peinado, R., Grözinger, U., Guàrdia, J., Guijarro, A., de Guindos, E., Hatzes, A. P., Hauschildt, P. H., Hedrosa, R. P., Helmling, J., Henning, T., Hermelo, I., Arabi, R. Hernández, Castaño, L. Hernández, Otero, F. Hernández, Hintz, D., Huke, P., Huber, A., Jeffers, S. V., Johnson, E. N., de Juan, E., Kaminski, A., Kemmer, J., Kim, M., Klahr, H., Klein, R., Klüter, J., Klutsch, A., Kossakowski, D., Kürster, M., Labarga, F., Lafarga, M., Llamas, M., Lampón, M., Lara, L. M., Launhardt, R., Lázaro, F. J., Lodieu, N., del Fresno, M. López, López-Comazzi, A., López-Puertas, M., Salas, J. F. López, López-Santiago, J., Madinabeitia, H. Magán, Mall, U., Mancini, L., Mandel, H., Marfil, E., Molina, J. A. Marín, Fernández, D. Maroto, Martín, E. L., Martín-Fernández, P., Martín-Ruiz, S., Marvin, C. J., Mirabet, E., Montañés-Rodríguez, P., Montes, D., Moreno-Raya, M. E., Nagel, E., Naranjo, V., Narita, N., Nortmann, L., Nowak, G., Ofir, A., Oshagh, M., Panduro, J., Parviainen, H., Pascual, J., Passegger, V. M., Pavlov, A., Pedraz, S., Pérez-Calpena, A., Medialdea, D. Pérez, Perger, M., Perryman, M. A. C., Rabaza, O., Ballesta, A. Ramón, Rebolo, R., Redondo, P., Reffert, S., Reinhardt, S., Rhode, P., Rix, H. -W., Rodler, F., Trinidad, A. Rodríguez, Rosich, A., Sadegi, S., Sánchez-Blanco, E., Carrasco, M. A. Sánchez, Sánchez-López, A., Sanz-Forcada, J., Sarkis, P., Sarmiento, L. F., Schäfer, S., Schmitt, J. H. M. M., Schöfer, P., Schweitzer, A., Seifert, W., Shulyak, D., Solano, E., Sota, A., Stahl, O., Stock, S., Strachan, J. B. P., Stuber, T., Stürmer, J., Suárez, J. C., Tabernero, H. M., Pinto, M. Tala, Trifonov, T., Veredas, G., Linares, J. I. Vico, Vilardell, F., Wagner, K., Wolthoff, V., Xu, W., Yan, F., and Osorio, M. R. Zapatero

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Context. Teegarden's Star is the brightest and one of the nearest ultra-cool dwarfs in the solar neighbourhood. For its late spectral type (M7.0V), the star shows relatively little activity and is a prime target for near-infrared radial velocity surveys such as CARMENES. Aims. As part of the CARMENES search for exoplanets around M dwarfs, we obtained more than 200 radial-velocity measurements of Teegarden's Star and analysed them for planetary signals. Methods. We find periodic variability in the radial velocities of Teegarden's Star. We also studied photometric measurements to rule out stellar brightness variations mimicking planetary signals. Results. We find evidence for two planet candidates, each with $1.1M_\oplus$ minimum mass, orbiting at periods of 4.91 and 11.4 d, respectively. No evidence for planetary transits could be found in archival and follow-up photometry. Small photometric variability is suggestive of slow rotation and old age. Conclusions. The two planets are among the lowest-mass planets discovered so far, and they are the first Earth-mass planets around an ultra-cool dwarf for which the masses have been determined using radial velocities., Comment: A&A 627, A49. 26 pages, 17 figures, 6 tables. Press release available at http://www.astro.physik.uni-goettingen.de/~zechmeister/teegarden/teegarden.html. v2: two authors and one reference added

Published
2019
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3. The CARMENES search for exoplanets around M dwarfs - HD 147379b: A nearby Neptune in the temperate zone of an early-M dwarf

Author

Reiners, A., Ribas, I., Zechmeister, M., Caballero, J. A., Trifonov, T., Dreizler, S., Morales, J. C., Tal-Or, L., Lafarga, M., Quirrenbach, A., Amado, P. J., Kaminski, A., Jeffers, S. V., Aceituno, J., Béjar, V. J. S., Guàrdia, J., Guenther, E. W., Hagen, H. -J., Montes, D., Passegger, V. M., Seifert, W., Schweitzer, A., Cortés-Contreras, M., Abril, M., Alonso-Floriano, F. J., Eiff, M. Ammler-von, Antona, R., Anglada-Escudé, G., Anwand-Heerwart, H., Arroyo-Torres, B., Azzaro, M., Baroch, D., Barrado, D., Bauer, F. F., Becerril, S., Benítez, D., Berdiñas, Z. M., Bergond, G., Blümcke, M., Brinkmöller, M., del Burgo, C., Cano, J., Vázquez, M. C. Cárdenas, Casal, E., Cifuentes, C., Claret, A., Colomé, J., Czesla, S., Díez-Alonso, E., Feiz, C., Fernández, M., Ferro, I. M., Fuhrmeister, B., Galadí-Enríquez, D., Garcia-Piquer, A., Vargas, M. L. García, Gesa, L., Galera, V. Gómez, Hernández, J. I. González, González-Peinado, R., Grözinger, U., Grohnert, S., Guijarro, A., de Guindos, E., Gutiérrez-Soto, J., Hatzes, A. P., Hauschildt, P. H., Hedrosa, R. P., Helmling, J., Henning, Th., Hermelo, I., Arabí, R. Hernández, Castaño, L. Hernández, Hernando, F. Hernández, Herrero, E., Huber, A., Huke, P., Johnson, E. N., de Juan, E., Kim, M., Klein, R., Klüter, J., Klutsch, A., Kürster, M., Labarga, F., Lamert, A., Lampón, M., Lara, L. M., Laun, W., Lemke, U., Lenzen, R., Launhardt, R., del Fresno, M. López, López-González, M. J., López-Puertas, M., Salas, J. F. López, López-Santiago, J., Luque, R., Madinabeitia, H. Magán, Mall, U., Mancini, L., Mandel, H., Marfil, E., Molina, J. A. Marín, Fernández, D. Maroto, Martín, E. L., Martín-Ruiz, S., Marvin, C. J., Mathar, R. J., Mirabet, E., Moreno-Raya, M. E., Moya, A., Mundt, R., Nagel, E., Naranjo, V., Nortmann, L., Nowak, G., Ofir, A., Oreiro, R., Pallé, E., Panduro, J., Pascual, J., Pavlov, A., Pedraz, S., Pérez-Calpena, A., Medialdea, D. Pérez, Perger, M., Perryman, M. A. C., Pluto, M., Rabaza, O., Ramón, A., Rebolo, R., Redondo, P., Reffert, S., Reinhart, S., Rhode, P., Rix, H. -W., Rodler, F., Rodríguez, E., Rodríguez-López, C., Trinidad, A. Rodríguez, Rohloff, R. -R., Rosich, A., Sadegi, S., Sánchez-Blanco, E., Carrasco, M. A. Sánchez, Sánchez-López, A., Sanz-Forcada, J., Sarkis, P., Sarmiento, L. F., Schäfer, S., Schmitt, J. H. M. M., Schiller, J., Schöfer, P., Solano, E., Stahl, O., Strachan, J. B. P., Stürmer, J., Suárez, J. C., Tabernero, H. M., Tala, M., Tulloch, S. M., Ulbrich, R. -G., Veredas, G., Linares, J. I. Vico, Vilardell, F., Wagner, K., Winkler, J., Wolthoff, V., Xu, W., Yan, F., and Osorio, M. R. Zapatero

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract

We report on the first star discovered to host a planet detected by radial velocity (RV) observations obtained within the CARMENES survey for exoplanets around M dwarfs. HD 147379 ($V = 8.9$ mag, $M = 0.58 \pm 0.08$ M$_{\odot}$), a bright M0.0V star at a distance of 10.7 pc, is found to undergo periodic RV variations with a semi-amplitude of $K = 5.1\pm0.4$ m s$^{-1}$ and a period of $P = 86.54\pm0.06$ d. The RV signal is found in our CARMENES data, which were taken between 2016 and 2017, and is supported by HIRES/Keck observations that were obtained since 2000. The RV variations are interpreted as resulting from a planet of minimum mass $m_{\rm p}\sin{i} = 25 \pm 2$ M$_{\oplus}$, 1.5 times the mass of Neptune, with an orbital semi-major axis $a = 0.32$ au and low eccentricity ($e < 0.13$). HD 147379b is orbiting inside the temperate zone around the star, where water could exist in liquid form. The RV time-series and various spectroscopic indicators show additional hints of variations at an approximate period of 21.1d (and its first harmonic), which we attribute to the rotation period of the star., Comment: accepted for publication as A&A Letter

Published
2017
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4. The CARMENES search for exoplanets around M dwarfs: High-resolution optical and near-infrared spectroscopy of 324 survey stars

Author

Reiners, A., Zechmeister, M., Caballero, J. A., Ribas, I., Morales, J. C., Jeffers, S. V., Schöfer, P., Tal-Or, L., Quirrenbach, A., Amado, P. J., Kaminski, A., Seifert, W., Abril, M., Aceituno, J., Alonso-Floriano, F. J., Eiff, M. Ammler-von, Antona, R., Anglada-Escudé, G., Anwand-Heerwart, H., Arroyo-Torres, B., Azzaro, M., Baroch, D., Barrado, D., Bauer, F. F., Becerril, S., Béjar, V. J. S., Benítez, D., Berdiñas, Z. M., Bergond, G., Blümcke, M., Brinkmöller, M., del Burgo, C., Cano, J., Vázquez, M. C. Cárdenas, Casal, E., Cifuentes, C., Claret, A., Colomé, J., Cortés-Contreras, M., Czesla, S., Díez-Alonso, E., Dreizler, S., Feiz, C., Fernández, M., Ferro, I. M., Fuhrmeister, B., Galadí-Enríquez, D., Garcia-Piquer, A., Vargas, M. L. García, Gesa, L., Gómez, V., Galera, Hernández, J. I. González, González-Peinado, R., Grözinger, U., Grohnert, S., Guàrdia, J., Guenther, E. W., Guijarro, A., de Guindos, E., Gutiérrez-Soto, J., Hagen, H. -J., Hatzes, A. P., Hauschildt, P. H., Hedrosa, R. P., Helmling, J., Henning, Th., Hermelo, I., Arabí, R. Hernández, Castaño, L. Hernández, Hernando, F. Hernández, Herrero, E., Huber, A., Huke, P., Johnson, E., de Juan, E., Kim, M., Klein, R., Klüter, J., Klutsch, A., Kürster, M., Lafarga, M., Lamert, A., Lampón, M., Lara, L. M., Laun, W., Lemke, U., Lenzen, R., Launhardt, R., del Fresno, M. López, López-González, J., López-Puertas, M., Salas, J. F. López, López-Santiago, J., Luque, R., Madinabeitia, H. Magán, Mall, U., Mancini, L., Mandel, H., Marfil, E., Molina, J. A. Marín, Maroto, D., Fernández, Martín, E. L., Martín-Ruiz, S., Marvin, C. J., Mathar, R. J., Mirabet, E., Montes, D., Moreno-Raya, M. E., Moya, A., Mundt, R., Nagel, E., Naranjo, V., Nortmann, L., Nowak, G., Ofir, A., Oreiro, R., Pallé, E., Panduro, J., Pascual, J., Passegger, V. M., Pavlov, A., Pedraz, S., Pérez-Calpena, A., Medialdea, D. Pérez, Perger, M., Perryman, M. A. C., Pluto, M., Rabaza, O., Ramón, A., Rebolo, R., Redondo, P., Reffert, S., Reinhart, S., Rhode, P., Rix, H. -W., Rodler, F., Rodríguez, E., Rodríguez-López, C., Trinidad, A. Rodríguez, Rohloff, R. -R., Rosich, A., Sadegi, S., Sánchez-Blanco, E., Carrasco, M. A. Sánchez, Sánchez-López, A., Sanz-Forcada, J., Sarkis, P., Sarmiento, L. F., Schäfer, S., Schmitt, J. H. M. M., Schiller, J., Schweitzer, A., Solano, E., Stahl, O., Strachan, J. B. P., Stürmer, J., Suárez, J. C., Tabernero, H. M., Tala, M., Trifonov, T., Tulloch, S. M., Ulbrich, R. G., Veredas, G., Linares, J. I. Vico, Vilardell, F., Wagner, K., Winkler, J., Wolthoff, V., Xu, W., Yan, F., and Osorio, M. R. Zapatero

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Earth and Planetary Astrophysics
Abstract

The CARMENES radial velocity (RV) survey is observing 324 M dwarfs to search for any orbiting planets. In this paper, we present the survey sample by publishing one CARMENES spectrum for each M dwarf. These spectra cover the wavelength range 520--1710nm at a resolution of at least $R > 80,000$, and we measure its RV, H$\alpha$ emission, and projected rotation velocity. We present an atlas of high-resolution M-dwarf spectra and compare the spectra to atmospheric models. To quantify the RV precision that can be achieved in low-mass stars over the CARMENES wavelength range, we analyze our empirical information on the RV precision from more than 6500 observations. We compare our high-resolution M-dwarf spectra to atmospheric models where we determine the spectroscopic RV information content, $Q$, and signal-to-noise ratio. We find that for all M-type dwarfs, the highest RV precision can be reached in the wavelength range 700--900nm. Observations at longer wavelengths are equally precise only at the very latest spectral types (M8 and M9). We demonstrate that in this spectroscopic range, the large amount of absorption features compensates for the intrinsic faintness of an M7 star. To reach an RV precision of 1ms$^{-1}$ in very low mass M dwarfs at longer wavelengths likely requires the use of a 10m class telescope. For spectral types M6 and earlier, the combination of a red visual and a near-infrared spectrograph is ideal to search for low-mass planets and to distinguish between planets and stellar variability. At a 4m class telescope, an instrument like CARMENES has the potential to push the RV precision well below the typical jitter level of 3-4ms$^{-1}$., Comment: accepted for publication in A&A, 13 pages plus 40 pages spectral atlas, first 10 atlas pages are reduced in quality to fit arXiv size limit; one CARMENES spectrum for each of the 324 stars is published in electronic format at http://carmenes.cab.inta-csic.es/

Published
2017
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5. The CARMENES search for exoplanets around M dwarfs. First visual-channel radial-velocity measurements and orbital parameter updates of seven M-dwarf planetary systems

Author

Trifonov, T., Kürster, M., Zechmeister, M., Tal-Or, L., Caballero, J. A., Quirrenbach, A., Amado, P. J., Ribas, I., Reiners, A., Reffert, S., Dreizler, S., Hatzes, A. P., Kaminski, A., Launhardt, R., Henning, Th., Montes, D., Béjar, V. J. S., Mundt, R., Pavlov, A., Schmitt, J. H. M. M., Seifert, W., Morales, J. C., Nowak, G., Jeffers, S. V., Rodríguez-López, C., del Burgo, C., Anglada-Escudé, G., López-Santiago, J., Mathar, R. J., Eiff, M. Ammler-von, Guenther, E. W., Barrado, D., Hernández, J. I. González, Mancini, L., Stürmer, J., Abril, M., Aceituno, J., Alonso-Floriano, F. J., Antona, R., Anwand-Heerwart, H., Arroyo-Torres, B., Azzaro, M., Baroch, D., Bauer, F. F., Becerril, S., Benítez, D., Berdiñas, Z. M., Bergond, G., Blümcke, M., Brinkmöller, M., Cano, J., Vázquez, M. C. Cárdenas, Casal, E., Cifuentes, C., Claret, A., Colomé, J., Cortés-Contreras, M., Czesla, S., Díez-Alonso, E., Feiz, C., Fernández, M., Ferro, I. M., Fuhrmeister, B., Galadí-Enríquez, D., Garcia-Piquer, A., Vargas, M. L. García, Gesa, L., Galera, V. Gómez, González-Peinado, R., Grözinger, U., Grohnert, S., Guàrdia, J., Guijarro, A., de Guindos, E., Gutiérrez-Soto, J., Hagen, H. -J., Hauschildt, P. H., Hedrosa, R. P., Helmling, J., Hermelo, I., Arabí, R. Hernández, Castaño, L. Hernández, Hernando, F. Hernández, Herrero, E., Huber, A., Huke, P., Johnson, E., de Juan, E., Kim, M., Klein, R., Klüter, J., Klutsch, A., Lafarga, M., Lampón, M., Lara, L. M., Laun, W., Lemke, U., Lenzen, R., del Fresno, M. López, López-González, J., López-Puertas, M., Salas, J. F. López, Luque, R., Madinabeitia, H. Magán, Mall, U., Mandel, H., Marfil, E., Molina, J. A. Marín, Fernández, D. Maroto, Martín, E. L., Martín-Ruiz, S., Marvin, C. J., Mirabet, E., Moya, A., Moreno-Raya, M. E., Nagel, E., Naranjo, V., Nortmann, L., Ofir, A., Oreiro, R., Pallé, E., Panduro, J., Pascual, J., Passegger, V. M., Pedraz, S., Pérez-Calpena, A., Medialdea, D. Pérez, Perger, M., Perryman, M. A. C., Pluto, M., Rabaza, O., Ramón, A., Rebolo, R., Redondo, P., Reinhardt, S., Rhode, P., Rix, H. -W., Rodler, F., Rodríguez, E., Trinidad, A. Rodríguez, Rohloff, R. -R., Rosich, A., Sadegi, S., Sánchez-Blanco, E., Carrasco, M. A. Sánchez, Sánchez-López, A., Sanz-Forcada, J., Sarkis, P., Sarmiento, L. F., Schäfer, S., Schiller, J., Schöfer, P., Schweitzer, A., Solano, E., Stahl, O., Strachan, J. B. P., Suárez, J. C., Tabernero, H. M., Tala, M., Tulloch, S. M., Veredas, G., Linares, J. I. Vico, Vilardell, F., Wagner, K., Winkler, J., Wolthoff, V., Xu, W., Yan, F., and Osorio, M. R. Zapatero

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Context: The main goal of the CARMENES survey is to find Earth-mass planets around nearby M-dwarf stars. Seven M-dwarfs included in the CARMENES sample had been observed before with HIRES and HARPS and either were reported to have one short period planetary companion (GJ15A, GJ176, GJ436, GJ536 and GJ1148) or are multiple planetary systems (GJ581 and GJ876). Aims: We aim to report new precise optical radial velocity measurements for these planet hosts and test the overall capabilities of CARMENES. Methods: We combined our CARMENES precise Doppler measurements with those available from HIRES and HARPS and derived new orbital parameters for the systems. Bona-fide single planet systems are fitted with a Keplerian model. The multiple planet systems were analyzed using a self-consistent dynamical model and their best fit orbits were tested for long-term stability. Results: We confirm or provide supportive arguments for planets around all the investigated stars except for GJ15A, for which we find that the post-discovery HIRES data and our CARMENES data do not show a signal at 11.4 days. Although we cannot confirm the super-Earth planet GJ15Ab, we show evidence for a possible long-period ($P_{\rm c}$ = 7025$_{-629}^{+972}$ d) Saturn-mass ($m_{\rm c} \sin i$ = 51.8$_{-5.8}^{+5.5}M_\oplus$) planet around GJ15A. In addition, based on our CARMENES and HIRES data we discover a second planet around GJ1148, for which we estimate a period $P_{\rm c}$ = 532.6$_{-2.5}^{+4.1}$ d, eccentricity $e_{\rm c}$ = 0.34$_{-0.06}^{+0.05}$ and minimum mass $m_{\rm c} \sin i$ = 68.1$_{-2.2}^{+4.9}M_\oplus$. Conclusions: The CARMENES optical radial velocities have similar precision and overall scatter when compared to the Doppler measurements conducted with HARPS and HIRES. We conclude that CARMENES is an instrument that is up to the challenge of discovering rocky planets around low-mass stars., Comment: Accepted for publication in A&A, 24 pages, 16 figures, 14 tables

Published
2017
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6. Efficient scheduling of astronomical observations. Application to the CARMENES radial-velocity survey

Author

Garcia-Piquer, A., Morales, J. C., Ribas, I., Colomé, J., Guàrdia, J., Perger, M., Caballero, J. A., Cortés-Contreras, M., Jeffers, S. V., Reiners, A., Amado, P. J., Quirrenbach, A., and Seifert, W.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Targeted spectroscopic exoplanet surveys face the challenge of maximizing their planet detection rates by means of careful planning. The number of possible observation combinations for a large exoplanet survey, i.e., the sequence of observations night after night, both in total time and amount of targets, is enormous. Sophisticated scheduling tools and the improved understanding of the exoplanet population are employed to investigate an efficient and optimal way to plan the execution of observations. This is applied to the CARMENES instrument, which is an optical and infrared high-resolution spectrograph that has started a survey of about 300 M-dwarf stars in search for terrestrial exoplanets. We use evolutionary computation techniques to create an automatic scheduler that minimizes the idle periods of the telescope and that distributes the observations among all the targets using configurable criteria. We simulate the case of the CARMENES survey with a realistic sample of targets, and we estimate the efficiency of the planning tool both in terms of telescope operations and planet detection. Our scheduling simulations produce plans that use about 99$\%$ of the available telescope time (including overheads) and optimally distribute the observations among the different targets. Under such conditions, and using current planet statistics, the optimized plan using this tool should allow the CARMENES survey to discover about 65$\%$ of the planets with radial-velocity semi-amplitudes greater than 1$~m\thinspace s^{-1}$ when considering only photon noise. The simulations using our scheduling tool show that it is possible to optimize the survey planning by minimizing idle instrument periods and fulfilling the science objectives in an efficient manner to maximize the scientific return., Comment: 18 pages, 8 figures, 6 tables

Published
2017
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7. The EChO science case

Author

Tinetti, Giovanna, Drossart, Pierre, Eccleston, Paul, Hartogh, Paul, Isaak, Kate, Linder, Martin, Lovis, Christophe, Micela, Giusi, Ollivier, Marc, Puig, Ludovic, Ribas, Ignasi, Snellen, Ignas, Allard, Bruce Swinyard. France, Barstow, Joanna, Cho, James, Coustenis, Athena, Cockell, Charles, Correia, Alexandre, Decin, Leen, de Kok, Remco, Deroo, Pieter, Encrenaz, Therese, Forget, Francois, Glasse, Alistair, Griffith, Caitlin, Guillot, Tristan, Koskinen, Tommi, Lammer, Helmut, Leconte, Jeremy, Maxted, Pierre, Mueller-Wodarg, Ingo, Nelson, Richard, North, Chris, Pallé, Enric, Pagano, Isabella, Piccioni, Guseppe, Pinfield, David, Selsis, Franck, Sozzetti, Alessandro, Stixrude, Lars, Tennyson, Jonathan, Turrini, Diego, Beaulieu, Mariarosa Zapatero-Osorio. Jean-Philippe, Grodent, Denis, Guedel, Manuel, Luz, David, Nørgaard-Nielsen, Hans Ulrik, Ray, Tom, Rickman, Hans, Selig, Avri, Banaszkiewicz, Mark Swain. Marek, Barlow, Mike, Bowles, Neil, Branduardi-Raymont, Graziella, Foresto, Vincent Coudé du, Gerard, Jean-Claude, Gizon, Laurent, Hornstrup, Allan, Jarchow, Christopher, Kerschbaum, Franz, Kovacs, Géza, Lagage, Pierre-Olivier, Lim, Tanya, Lopez-Morales, Mercedes, Malaguti, Giuseppe, Pace, Emanuele, Pascale, Enzo, Vandenbussche, Bart, Wright, Gillian, Adriani, Gonzalo Ramos Zapata. Alberto, Azzollini, Ruymán, Balado, Ana, Bryson, Ian, Burston, Raymond, Colomé, Josep, Crook, Martin, Di Giorgio, Anna, Griffin, Matt, Hoogeveen, Ruud, Ottensamer, Roland, Irshad, Ranah, Middleton, Kevin, Morgante, Gianluca, Pinsard, Frederic, Rataj, Mirek, Reess, Jean-Michel, Savini, Giorgio, Schrader, Jan-Rutger, Stamper, Richard, Abe, Berend Winter. L., Abreu, M., Achilleos, N., Ade, P., Adybekian, V., Affer, L., Agnor, C., Agundez, M., Alard, C., Alcala, J., Prieto, C. Allende, Floriano, F. J. Alonso, Altieri, F., Iglesias, C. A. Alvarez, Amado, P., Andersen, A., Aylward, A., Baffa, C., Bakos, G., Ballerini, P., Banaszkiewicz, M., Barber, R. J., Barrado, D., Barton, E. J., Batista, V., Bellucci, G., Avilés, J. A. Belmonte, Berry, D., Bézard, B., Biondi, D., Błęcka, M., Boisse, I., Bonfond, B., Bordé, P., Börner, P., Bouy, H., Brown, L., Buchhave, L., Budaj, J., Bulgarelli, A., Burleigh, M., Cabral, A., Capria, M. T., Cassan, A., Cavarroc, C., Cecchi-Pestellini, C., Cerulli, R., Chadney, J., Chamberlain, S., Charnoz, S., Jessen, N. Christian, Ciaravella, A., Claret, A., Claudi, R., Coates, A., Cole, R., Collura, A., Cordier, D., Covino, E., Danielski, C., Damasso, M., Deeg, H. J., Delgado-Mena, E., Del Vecchio, C., Demangeon, O., De Sio, A., De Wit, J., Dobrijévic, M., Doel, P., Dominic, C., Dorfi, E., Eales, S., Eiroa, C., Contreras, M. Espinoza, Esposito, M., Eymet, V., Fabrizio, N., Fernández, M., Castella, B. Femenía, Figueira, P., Filacchione, G., Fletcher, L., Focardi, M., Fossey, S., Fouqué, P., Frith, J., Galand, M., Gambicorti, L., Gaulme, P., López, R. J. García, Garcia-Piquer, A., Gear, W., Gerard, J. -C., Gesa, L., Giani, E., Gianotti, F., Gillon, M., Giro, E., Giuranna, M., Gomez, H., Gomez-Leal, I., Hernandez, J. Gonzalez, Merino, B. González, Graczyk, R., Grassi, D., Guardia, J., Guio, P., Gustin, J., Hargrave, P., Haigh, J., Hébrard, E., Heiter, U., Heredero, R. L., Herrero, E., Hersant, F., Heyrovsky, D., Hollis, M., Hubert, B., Hueso, R., Israelian, G., Iro, N., Irwin, P., Jacquemoud, S., Jones, G., Jones, H., Justtanont, K., Kehoe, T., Kerschbaum, F., Kerins, E., Kervella, P., Kipping, D., Koskinen, T., Krupp, N., Lahav, O., Laken, B., Lanza, N., Lellouch, E., Leto, G., Goldaracena, J. Licandro, Lithgow-Bertelloni, C., Liu, S. J., Cicero, U. Lo, Lodieu, N., Lognonné, P., Lopez-Puertas, M., Lopez-Valverde, M. A., Rasmussen, I. Lundgaard, Luntzer, A., Machado, P., MacTavish, C., Maggio, A., Maillard, J. -P., Magnes, W., Maldonado, J., Mall, U., Marquette, J. -B., Mauskopf, P., Massi, F., Maurin, A. -S., Medvedev, A., Michaut, C., Miles-Paez, P., Montalto, M., Rodríguez, P. Montañés, Monteiro, M., Montes, D., Morais, H., Morales, J. C., Morales-Calderón, M., Morello, G., Martín, A. Moro, Moses, J., Bedon, A. Moya, Alcaino, F. Murgas, Oliva, E., Orton, G., Palla, F., Pancrazzi, M., Pantin, E., Parmentier, V., Parviainen, H., Ramírez, K. Y. Peña, Peralta, J., Perez-Hoyos, S., Petrov, R., Pezzuto, S., Pietrzak, R., Pilat-Lohinger, E., Piskunov, N., Prinja, R., Prisinzano, L., Polichtchouk, I., Poretti, E., Radioti, A., Ramos, A. A., Rank-Lüftinger, T., Read, P., Readorn, K., López, R. Rebolo, Rebordão, J., Rengel, M., Rezac, L., Rocchetto, M., Rodler, F., Béjar, V. J. Sánchez, Lavega, A. Sanchez, Sanromá, E., Santos, N., Forcada, J. Sanz, Scandariato, G., Schmider, F. -X., Scholz, A., Scuderi, S., Sethenadh, J., Shore, S., Showman, A., Sicardy, B., Sitek, P., Smith, A., Soret, L., Sousa, S., Stiepen, A., Stolarski, M., Strazzulla, G., Tabernero, H. M, Tanga, P., Tecsa, M., Temple, J., Terenzi, L., Tessenyi, M., Testi, L., Thompson, S., Thrastarson, H., Tingley, B. W., Trifoglio, M., Torres, J. Martín, Tozzi, A., Turrini, D., Varley, R., Vakili, F., de Val-Borro, M., Valdivieso, M. L., Venot, O., Villaver, E., Vinatier, S., Viti, S., Waldmann, I., Waltham, D., Ward-Thompson, D., Waters, R., Watkins, C., Watson, D., Wawer, P., Wawrzaszk, A., White, G., Widemann, T., Winek, W., Wiśniowski, T., Yelle, R., Yung, Y., and Yurchenko, S. N.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

The discovery of almost 2000 exoplanets has revealed an unexpectedly diverse planet population. Observations to date have shown that our Solar System is certainly not representative of the general population of planets in our Milky Way. The key science questions that urgently need addressing are therefore: What are exoplanets made of? Why are planets as they are? What causes the exceptional diversity observed as compared to the Solar System? EChO (Exoplanet Characterisation Observatory) has been designed as a dedicated survey mission for transit and eclipse spectroscopy capable of observing a large and diverse planet sample within its four-year mission lifetime. EChO can target the atmospheres of super-Earths, Neptune-like, and Jupiter-like planets, in the very hot to temperate zones (planet temperatures of 300K-3000K) of F to M-type host stars. Over the next ten years, several new ground- and space-based transit surveys will come on-line (e.g. NGTS, CHEOPS, TESS, PLATO), which will specifically focus on finding bright, nearby systems. The current rapid rate of discovery would allow the target list to be further optimised in the years prior to EChO's launch and enable the atmospheric characterisation of hundreds of planets. Placing the satellite at L2 provides a cold and stable thermal environment, as well as a large field of regard to allow efficient time-critical observation of targets randomly distributed over the sky. A 1m class telescope is sufficiently large to achieve the necessary spectro-photometric precision. The spectral coverage (0.5-11 micron, goal 16 micron) and SNR to be achieved by EChO, thanks to its high stability and dedicated design, would enable a very accurate measurement of the atmospheric composition and structure of hundreds of exoplanets., Comment: 50 pages, 30 figures. Experimental Astronomy

Published
2015
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8. Single-factor lifting and factorization of polynomials over local fields

Author

Guàrdia, J., Nart, E., and Pauli, S.

Subjects
Mathematics - Number Theory, 11S15, 11S04, 11Y40
Abstract

Let $f(x)$ be a separable polynomial over a local field. Montes algorithm computes certain approximations to the different irreducible factors of $f(x)$, with strong arithmetic properties. In this paper we develop an algorithm to improve any one of these approximations, till a prescribed precision is attained. The most natural application of this "single-factor lifting" routine is to combine it with Montes algorithm to provide a fast polynomial factorization algorithm. Moreover, the single-factor lifting algorithm may be applied as well to accelerate the computational resolution of several global arithmetic problems in which the improvement of an approximation to a single local irreducible factor of a polynomial is required., Comment: 9 figures

Published
2011

9. Arithmetic in big number fields: the '+Ideals' package

Author

Guardia, J., Montes, J., and Nart, E.

Subjects
Mathematics - Number Theory
Abstract

We introduce our package '+Ideals' for Magma, designed to perform the basic tasks related to ideals in number fields without pre-computing integral bases. It is based on Montes algorithm and a number of local techniques that we have developed in a series of papers in the last years.

Published
2010

10. Higher Newton polygons and integral bases

Author

Guardia, J., Montes, J., and Nart, E.

Subjects
Mathematics - Number Theory, 11Y40, 14G15, 14H05
Abstract

Let $A$ be a Dedekind domain, $K$ the fraction field, $\p$ a non-zero prime ideal of $A$, and $K_\pp$ the completion of $K$ with respect to the $\p$-adic topology. At the input of a monic irreducible separable polynomial, $f(x)\in A[x]$, Montes algorithm determines the factorization of $f(x)$ over $K_\pp[x]$, and it provides essential arithmetic information about the finite extensions of $K_\pp$ determined by the different irreducible factors. In particular, it can be used to compute $\p$-integral bases of the extension of $K$ determined by $f(x)$ \cite{newapp}. In this paper we present new (and faster) methods to compute $\p$-integral bases, based on the use of the quotients of certain divisions with remainder of $f(x)$ that occur along the flow of Montes algorithm.

Published
2009

11. Jacobian Nullwerte, Periods and Symmetric Equations for Hyperelliptic Curves

Author

Guàrdia, J.

Subjects
Mathematics - Number Theory, Mathematics - Algebraic Geometry, 11G30, 14H42
Abstract

We propose a solution to the hyperelliptic Schottky problem, based on the use of Jacobian Nullwerte and symmetric models for hyperelliptic curves. Both ingredients are interesting on its own, since the first provide period matrices which can be geometrically described, and the second have remarkable arithmetic properties., Comment: To appear in "Annales de l'Institut Fourier"

Published
2006

14. Gut microbiota is associated with metabolic health in children with obesity

Author

Alcazar, M., primary, Escribano, J., additional, Ferré, N., additional, Closa-Monasterolo, R., additional, Selma-Royo, M., additional, Feliu, A., additional, Castillejo, G., additional, Luque, V., additional, Feliu-Rovira, A., additional, Muñoz-Hernando, J., additional, Gutiérrez-Marín, D., additional, Zaragoza-Jordana, M., additional, Gispert-Llauradó, M., additional, Rubio-Torrents, M.C., additional, Núñez-Roig, M., additional, Alcázar, M., additional, Sentís, S., additional, Esteve, M., additional, Monné-Gelonch, R., additional, Basora, J.M., additional, Flores, G., additional, Hsu, P., additional, Rey-Reñones, C., additional, Alegret, C., additional, Guillen, N., additional, Alegret-Basora, C., additional, Ferre, R., additional, Arasa, F., additional, Alejos, A.M., additional, Diéguez, M., additional, Serrano, M.A., additional, Mallafré, M., additional, González-Hidalgo, R., additional, Braviz, L., additional, Resa, A., additional, Palacios, M., additional, Sabaté, A., additional, Simón, L., additional, Losilla, A.C., additional, De La Torre, S., additional, Rosell, L., additional, Adell, N., additional, Pérez, C., additional, Tudela-Valls, C., additional, Caro-Garduño, R., additional, Salvadó, O., additional, Pedraza, A., additional, Conchillo, J., additional, Morillo, S., additional, Garcia, S., additional, Mur, E.M., additional, Paixà, S., additional, Tolós, S., additional, Martín, R., additional, Aguado, F.J., additional, Cabedo, J.L., additional, Quezada, L.G., additional, Domingo, M., additional, Ortega, M., additional, Garcia, R.M., additional, Romero, O., additional, Pérez, M., additional, Fernández, M., additional, Villalobos, M.E., additional, Ricomà, G., additional, Capell, E., additional, Bosch, M., additional, Donado, A., additional, Sanchis, F.J., additional, Boix, A., additional, Goñi, X., additional, Castilla, E., additional, Pinedo, M.M., additional, Supersaxco, L., additional, Ferré, M., additional, Contreras, J., additional, Sanz-Manrique, N., additional, Lara, A., additional, Rodríguez, M., additional, Pineda, T., additional, Segura, S., additional, Vidal, S., additional, Salvat, M., additional, Mimbrero, G., additional, Albareda, A., additional, Guardia, J., additional, Gil, S., additional, Lopez, M., additional, Ruiz-Escusol, S., additional, Gallardo, S., additional, Machado, P., additional, Bocanegra, R., additional, Espejo, T., additional, Vendrell, M., additional, Solé, C., additional, Urbano, R., additional, Vázquez, M.T., additional, Fernández-Antuña, L., additional, Barrio, M., additional, Baudoin, A., additional, González, N., additional, Olivé, R., additional, Lara, R.M., additional, Dinu, C., additional, Vidal, C., additional, González, S., additional, Ruiz-Morcillo, E., additional, Ainsa, M.E., additional, Vilalta, P., additional, Aranda, B., additional, Boada, A., additional, and Balcells, E., additional

Published
2022
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15. Psychometric Properties of Self‐Care Requisites Scale (SCRS‐h) in Hospitalized Patients Diagnosed With Schizophrenia

Author

Roldán‐Merino, Juan, Miguel‐Ruiz, Dolores, Lluch‐Canut, Ma Teresa, Puig‐Llobet, Montserrat, Feria‐Raposo, Isabel, Alba, AM, Albacar, N, Argemí, M, Blazquez, MC, Bogas, JL, Beltran, JJ, Cabello, I, Casas, I, Castro, M, Cobo, R, Cuesta, D, Falco, AM, Farreras, P, Ferré, C, Foix, A, Grumaches, G, Guardia, J, Herrero, MP, Jettha, C, Julia, E, Lleixà, MM, Haro, JM, Marquez, I, Menarguez, M, Miguel, J, Morcillo, E, Marquez, I, Moreno, A, Monteso, P, Montserrat, M, Nuñez, M, Ochoa, S, del Pino, J, Quilez, J, Ramió, A, Ramon, J, Royo, D, Sabadell, M, Saez, S, Santos, A, Selva, FJ, Senz, M, Soler, A, and Teba, S

Published
2017
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16. The EChO science case

Author

Tinetti, Giovanna, primary, Drossart, Pierre, additional, Eccleston, Paul, additional, Hartogh, Paul, additional, Isaak, Kate, additional, Linder, Martin, additional, Lovis, Christophe, additional, Micela, Giusi, additional, Ollivier, Marc, additional, Puig, Ludovic, additional, Ribas, Ignasi, additional, Snellen, Ignas, additional, Swinyard, Bruce, additional, Allard, France, additional, Barstow, Joanna, additional, Cho, James, additional, Coustenis, Athena, additional, Cockell, Charles, additional, Correia, Alexandre, additional, Decin, Leen, additional, de Kok, Remco, additional, Deroo, Pieter, additional, Encrenaz, Therese, additional, Forget, Francois, additional, Glasse, Alistair, additional, Griffith, Caitlin, additional, Guillot, Tristan, additional, Koskinen, Tommi, additional, Lammer, Helmut, additional, Leconte, Jeremy, additional, Maxted, Pierre, additional, Mueller-Wodarg, Ingo, additional, Nelson, Richard, additional, North, Chris, additional, Pallé, Enric, additional, Pagano, Isabella, additional, Piccioni, Guseppe, additional, Pinfield, David, additional, Selsis, Franck, additional, Sozzetti, Alessandro, additional, Stixrude, Lars, additional, Tennyson, Jonathan, additional, Turrini, Diego, additional, Zapatero-Osorio, Mariarosa, additional, Beaulieu, Jean-Philippe, additional, Grodent, Denis, additional, Guedel, Manuel, additional, Luz, David, additional, Nørgaard-Nielsen, Hans Ulrik, additional, Ray, Tom, additional, Rickman, Hans, additional, Selig, Avri, additional, Swain, Mark, additional, Banaszkiewicz, Marek, additional, Barlow, Mike, additional, Bowles, Neil, additional, Branduardi-Raymont, Graziella, additional, du Foresto, Vincent Coudé, additional, Gerard, Jean-Claude, additional, Gizon, Laurent, additional, Hornstrup, Allan, additional, Jarchow, Christopher, additional, Kerschbaum, Franz, additional, Kovacs, Géza, additional, Lagage, Pierre-Olivier, additional, Lim, Tanya, additional, Lopez-Morales, Mercedes, additional, Malaguti, Giuseppe, additional, Pace, Emanuele, additional, Pascale, Enzo, additional, Vandenbussche, Bart, additional, Wright, Gillian, additional, Ramos Zapata, Gonzalo, additional, Adriani, Alberto, additional, Azzollini, Ruymán, additional, Balado, Ana, additional, Bryson, Ian, additional, Burston, Raymond, additional, Colomé, Josep, additional, Crook, Martin, additional, Di Giorgio, Anna, additional, Griffin, Matt, additional, Hoogeveen, Ruud, additional, Ottensamer, Roland, additional, Irshad, Ranah, additional, Middleton, Kevin, additional, Morgante, Gianluca, additional, Pinsard, Frederic, additional, Rataj, Mirek, additional, Reess, Jean-Michel, additional, Savini, Giorgio, additional, Schrader, Jan-Rutger, additional, Stamper, Richard, additional, Winter, Berend, additional, Abe, L., additional, Abreu, M., additional, Achilleos, N., additional, Ade, P., additional, Adybekian, V., additional, Affer, L., additional, Agnor, C., additional, Agundez, M., additional, Alard, C., additional, Alcala, J., additional, Prieto, C. Allende, additional, Alonso Floriano, F. J., additional, Altieri, F., additional, Alvarez Iglesias, C. A., additional, Amado, P., additional, Andersen, A., additional, Aylward, A., additional, Baffa, C., additional, Bakos, G., additional, Ballerini, P., additional, Banaszkiewicz, M., additional, Barber, R. J., additional, Barrado, D., additional, Barton, E. J., additional, Batista, V., additional, Bellucci, G., additional, Belmonte Avilés, J. A., additional, Berry, D., additional, Bézard, B., additional, Biondi, D., additional, Błęcka, M., additional, Boisse, I., additional, Bonfond, B., additional, Bordé, P., additional, Börner, P., additional, Bouy, H., additional, Brown, L., additional, Buchhave, L., additional, Budaj, J., additional, Bulgarelli, A., additional, Burleigh, M., additional, Cabral, A., additional, Capria, M. T., additional, Cassan, A., additional, Cavarroc, C., additional, Cecchi-Pestellini, C., additional, Cerulli, R., additional, Chadney, J., additional, Chamberlain, S., additional, Christian Jessen, N., additional, Ciaravella, A., additional, Claret, A., additional, Claudi, R., additional, Coates, A., additional, Cole, R., additional, Collur, A., additional, Cordier, D., additional, Covino, E., additional, Danielski, C., additional, Damasso, M., additional, Deeg, H. J., additional, Delgado-Mena, E., additional, Del Vecchio, C., additional, Demangeon, O., additional, De Sio, A., additional, De Wit, J., additional, Dobrijévi, M., additional, Doel, P., additional, Dominic, C., additional, Dorfi, E., additional, Eales, S., additional, Eiroa, C., additional, Espinoza Contreras, M., additional, Esposito, M., additional, Eymet, V., additional, Fabrizio, N., additional, Fernández, M., additional, Femenía Castella, B., additional, Figueira, P., additional, Filacchione, G., additional, Fletcher, L., additional, Focardi, M., additional, Fossey, S., additional, Fouqué, P., additional, Frith, J., additional, Galand, M., additional, Gambicorti, L., additional, Gaulme, P., additional, García López, R. J., additional, Garcia-Piquer, A., additional, Gear, W., additional, Gerard, J. -C., additional, Gesa, L., additional, Giani, E., additional, Gianotti, F., additional, Gillon, M., additional, Giro, E., additional, Giuranna, M., additional, Gomez, H., additional, Gomez-Leal, I., additional, Gonzalez Hernandez, J., additional, GonzÁlez Merino, B., additional, Graczyk, R., additional, Grassi, D., additional, Guardia, J., additional, Guio, P., additional, Gustin, J., additional, Hargrave, P., additional, Haigh, J., additional, Hébrard, E., additional, Heiter, U., additional, Heredero, R. L., additional, Herrero, E., additional, Hersant, F., additional, Heyrovsky, D., additional, Hollis, M., additional, Hubert, B., additional, Hueso, R., additional, Israelian, G., additional, Iro, N., additional, Irwin, P., additional, Jacquemoud, S., additional, Jones, G., additional, Jones, H., additional, Justtanont, K., additional, Kehoe, T., additional, Kerschbaum, F., additional, Kerins, E., additional, Kervell, P., additional, Kipping, D., additional, Koskinen, T., additional, Krupp, N., additional, Lahav, O., additional, Laken, B., additional, Lanza, N., additional, Lellouch, E., additional, Leto, G., additional, Goldaracena, J. Licandro, additional, Bertelloni, C. Lithgow, additional, Liu, S. J., additional, Cicero, U. Lo, additional, Lodieu, N., additional, Lognonné, P., additional, Puertas, M. Lopez, additional, Valverde, M. A. Lopez, additional, Rasmussen, I. Lundgaard, additional, Luntzer, A., additional, Machado, P., additional, Tavish, C. Mac, additional, Maggio, A., additional, Maillard, J. P., additional, Magnes, W., additional, Maldonado, J., additional, Mall, U., additional, Marquette, J. B., additional, Mauskopf, P., additional, Massi, F., additional, Maurin, A. S., additional, Medvedev, A., additional, Michaut, C., additional, Paez, P. Miles, additional, Montalto, M., additional, Rodríguez, P. Montañés, additional, Monteiro, M., additional, Montes, D., additional, Morais, H., additional, Morale, J. C., additional, Morales-Calderón, M., additional, Morello, G., additional, Martín, A. Moro, additional, Moses, J., additional, Bedon, A. Moya, additional, Alcaino, F. Murgas, additional, Oliva, E., additional, Orton, G., additional, Palla, F., additional, Pancrazzi, M., additional, Pantin, E., additional, Parmentier, V., additional, Parviainen, H., additional, Ramirez, Y. Pena, additional, Peralta, J., additional, Perez-Hoyos, S., additional, Petrov, R., additional, Pezzuto, S., additional, Pietrzak, R., additional, Pilat-Lohinger, E., additional, Piskunov, N., additional, Prinja, R., additional, Prisinzano, L., additional, Polichtchouk, I., additional, Poretti, E., additional, Radioti, A., additional, Ramos, A., additional, Rank-Luftinger, T., additional, Read, P., additional, Readorn, K., additional, Lopez, R. Rebolo, additional, Rebordao, J., additional, Rengel, M., additional, Rezac, L., additional, Rocchetto, M., additional, Rodler, F., additional, Bejar, J. Sanchez, additional, Sanchez Lavega, A., additional, Sanroma, E., additional, Santos, N., additional, Forcada, J. Sanz, additional, Scandariato, G., additional, Schmider, F.- X., additional, Scholz, A., additional, Scuderi, S., additional, Sethenadh, J., additional, Shore, S., additional, Showman, A., additional, Sicardy, B., additional, Sitek, P., additional, Smith, A., additional, Soret, L., additional, Sousa, S., additional, Stiepen, A., additional, Stolarski, M., additional, Strazzulla, G., additional, Tabernero, H. M., additional, Tanga, P., additional, Tecsa, M., additional, Temple, J., additional, Terenzi, L., additional, Tessenyi, M., additional, Testi, L., additional, Thompson, S., additional, Thrastarson, H., additional, Tingley, B. W., additional, Trifoglio, M., additional, Torres, J. Martin, additional, Tozzi, A., additional, Turrini, D., additional, Varley, R., additional, Vakili, F., additional, de Val-Borro, M., additional, Valdivieso, M. L., additional, Venot, O., additional, Villaver, E., additional, Vinatier, S., additional, Viti, S., additional, Waldmann, I., additional, Waltham, D., additional, Ward-Thompson, D., additional, Waters, R., additional, Watkins, C., additional, Watson, D., additional, Wawer, P., additional, Wawrzaszk, A., additional, White, G., additional, Widemann, T., additional, Winek, W., additional, Wi.niowski, T., additional, Yelle, R., additional, Yung, Y., additional, and Yurchenko, S. N., additional

Published
2015
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22. POS1215 INFLUENCE OF CONFINEMENT CARRIED OUT BY PATIENTS WITH AUTOIMMUNE AND IMMUNE- MEDIATED INFLAMMATORY DISEASE WITH BIOLOGICAL TREATMENT ON COVID-19 INFECTION

Author

Font-Urgelles, J., primary, Mínguez, S., additional, Rodríguez-Diez, B., additional, Creus-Vila, L., additional, Esquius Rafat, M., additional, Fusta Novell, X., additional, Llao Guardia, J., additional, Sainz Arnau, E., additional, Lopez de Recalde-Martorell, M., additional, Arnau Bartes, A., additional, and Sallés Lizarzaburu, M., additional

Published
2021
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24. Increased tumour necrosis factor α production in mesenteric lymph nodes of cirrhotic patients with ascites. (Liver)

Author

Genesca, J., Marti, R., Rojo, F., Campos, F., Peribanez, V., Gonzalez, A., Castells, L., Ruiz-Marcellan, C., Margarit, C., Esteban, R., Guardia, J., and Segura, R.

Subjects
Lymphadenitis -- Physiological aspects, Tumor necrosis factor -- Physiological aspects, Liver cirrhosis -- Physiological aspects, Health, Physiological aspects
Abstract

Background: Cytokines produced in mesenteric lymph nodes of cirrhotic rats with bacterial translocation may participate in circulatory alterations of cirrhosis. Aim: To investigate whether cirrhotic patients present an increased local [...]

Published
2003

35. A comparison between phase-III trials and a phase-IV study of nalmefene in alcohol use disorder patients. Is there a difference?

Author

Barrio, P, Ortega, L, Guardia, J, Roncero, C, Yuguero, L, and Gual, A

Subjects
Phase-III trial, Nalmefene, Alcoholism, Alcohol use disorders, External validity, Efectes secundaris dels medicaments, Alcoholisme, Phase-IV trial, Drug side effects
Abstract

Concerns regarding the external validity of phase-III trials are common to many medical disciplines, with relevant discrepancies found between experimental and clinical samples in some diseases such as hypertension. The aim of this study was to compare the samples included in the pivotal, phase-III clinical trials of nalmefene with that of a recently conducted phase-IV trial. Baseline characteristics of the studies were compared through univariate analysis. Significant differences were found in the percentage of low-risk drinkers included. Differences were also found in the prescription and intake pattern of nalmefene, as well as in the rate of psychiatric and addictive comorbidities, which were much higher in the phase-IV study. These data suggest that in the field of alcohol use disorders there are also relevant differences between experimental and clinical samples, a fact that reinforces the need for phase-III trials to be balanced with observational, phase-IV trials.

Published
2019

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