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141 results on '"GUAN, Xiao Ming"'

1. Long-term outcomes of vulvar or vaginal cancer patients undergoing laparoendoscopic single-site inguinal lymphadenectomy

Author

Xu, Jing-Yun, Yu, Tian-Xiang, Guan, Xiao-Ming, Ding, Bo, Ren, Mu-Lan, and Shen, Yang

Subjects
Cancer patients -- Care and treatment -- Patient outcomes, Health
Abstract

Byline: Jing-Yun. Xu, Tian-Xiang. Yu, Xiao-Ming. Guan, Bo. Ding, Mu-Lan. Ren, Yang. Shen Introduction: Laparoendoscopic single-site inguinal lymphadenectomy (LESS-IL), a minimally invasive technique, has been reported in patients with vulvar [...]

Published
2024

3. Melanin-Concentrating Hormone 1 Receptor-Deficient Mice are Lean, Hyperactive, and Hyperphagic and Have Altered Metabolism

Author

Marsh, Donald J., Weingarth, Drew T., Novi, Dawn E., Chen, Howard Y., Trumbauer, Myrna E., Chen, Airu S., Guan, Xiao-Ming, Jiang, Michael M., Feng, Yue, Camacho, Ramon E., Shen, Zhu, Frazier, Easter G., Yu, Hong, Metzger, Joseph M., Kuca, Stephanie J., Shearman, Lauren P., Gopal-Truter, Shobhna, MacNeil, Douglas J., Strack, Alison M., MacIntyre, D. Euan, and Qian, Su

Published
2002

6. Percutaneous Endoscopic Posterior Lumbar Interbody Fusion with Unilateral Laminotomy for Bilateral Decompression Vs. Open Posterior Lumbar Interbody Fusion for the Treatment of Lumbar Spondylolisthesis

Author

He, Li-Ming, Li, Jia-Rui, Wu, Hao-Ran, Chang, Qiang, Guan, Xiao-Ming, Ma, Zhuo, and Feng, Hao-Yu

Subjects
Surgery
Abstract

BackgroundEndoscopic lumbar interbody fusion is a new technology that is mostly used for single-segment and unilateral lumbar spine surgery. The purpose of this study is to introduce percutaneous endoscopic posterior lumbar interbody fusion (PE-PLIF) with unilateral laminotomy for bilateral decompression (ULBD) for lumbar spondylolisthesis and evaluate the efficacy by comparing it with open posterior lumbar interbody fusion (PLIF).MethodsTwenty-eight patients were enrolled in PE-PLIF with the ULBD group and the open PLIF group. The perioperative data of the two groups were compared to evaluate the safety of PE-PLIF with ULBD. The visual analog scale (VAS) back pain, VAS leg pain, and Oswestry Disability Index (ODI) scores of the two groups preoperatively and postoperatively were compared to evaluate clinical efficacy. Preoperative and postoperative imaging data were collected to evaluate the effectiveness of the operation.ResultsNo differences in baseline data were found between the two groups (p > 0.05). The operation time in PE-PLIF with the ULBD group (221.2 ± 32.9 min) was significantly longer than that in the PLIF group (138.4 ± 25.7 min) (p p p p p p > 0.05). The fusion rates in PE-PLIF with the ULBD group and the PLIF group were 89.3% and 92.9% (p > 0.05), respectively, the cage subsidence rates were 14.3% and 17.9% (p > 0.05), respectively, and the lumbar spondylolisthesis reduction rates were 92.72 ± 6.39% and 93.54 ± 5.21%, respectively (p > 0.05).ConclusionThe results from this study indicate that ULBD can be successfully performed during PE-PLIF, and the combined procedure is a safe and reliable treatment method for lumbar spondylolisthesis.

Published
2022

7. The design and synthesis of potent, selective benzodiazepine sulfonamide bombesin receptor subtype 3 (BRS-3) agonists with an increased barrier of atropisomerization

Author

Chobanian, Harry R., Guo, Yan, Liu, Ping, Lanza, Thomas J., Jr., Chioda, Marc, Chang, Linda, Kelly, Theresa M., Kan, Yanqing, Palyha, Oksana, Guan, Xiao-Ming, Marsh, Donald J., Metzger, Joseph M., Raustad, Katie, Wang, Sheng-Ping, Strack, Alison M., Gorski, Judith N., Miller, Randy, Pang, Jianmei, Lyons, Kathy, Dragovic, Jasminka, Ning, Jian G., Schafer, Wes A., Welch, Christopher J., Gong, Xiaoyi, Gao, Ying-Duo, Hornak, Viktor, Reitman, Marc L., Nargund, Ravi P., and Lin, Linus S.

Published
2012
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8. Regulation of Energy Homeostasis by Bombesin Receptor Subtype-3: Selective Receptor Agonists for the Treatment of Obesity

Author

Guan, Xiao-Ming, Chen, Howard, Dobbelaar, Peter H., Dong, Yan, Fong, Tung M., Gagen, Karen, Gorski, Judith, He, Shuwen, Howard, Andrew D., Jian, Tianying, Jiang, Michael, Kan, Yanqing, Kelly, Theresa M., Kosinski, Jennifer, Lin, Linus S., Liu, Jian, Marsh, Donald J., Metzger, Joseph M., Miller, Randy, Nargund, Ravi P., Palyha, Oksana, Shearman, Lauren, Shen, Zhu, Stearns, Ralph, Strack, Alison M., Stribling, Sloan, Tang, Yui Sing, Wang, Sheng-Ping, White, Amanda, Yu, Hong, and Reitman, Marc L.

Published
2010
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9. Body temperature as a mouse pharmacodynamic response to bombesin receptor subtype-3 agonists and other potential obesity treatments

Author

Metzger, Joseph M., Gagen, Karen, Raustad, Kate A., Yang, Liming, White, Amanda, Wang, Sheng-Ping, Craw, Stephanie, Liu, Ping, Lanza, Thomas, Lin, Linus S., Nargund, Ravi P., Guan, Xiao-Ming, Strack, Alison M., and Reitman, Marc L.

Subjects
Obesity -- Drug therapy, Obesity -- Research, Bombesin -- Physiological aspects, Bombesin -- Research, Agonists (Biochemistry) -- Health aspects, Agonists (Biochemistry) -- Research, Biological sciences
Abstract

Treatment of rodents with a bombesin receptor subtype-3 (BRS-3) agonist reduces food intake and increases fasting metabolic rate, causing weight loss with continued treatment. In small mammals, core body temperature ([T.sub.b]) is regulated in part by nutritional status, with a reduced [T.sub.b] during fasting. We report that fed Brs3 knockout mice have a lower [T.sub.b], which is discordant with their nutritional status. Treatment of wild-type mice with a BRS-3 agonist increased [T.sub.b], more so when the baseline [T.sub.b] was reduced such as by fasting or during the inactive phase of the light cycle. With repeated BRS-3 agonist dosing, the [T.sub.b] increase attenuated despite continued weight loss efficacy. The increase in [T.sub.b] was not prevented by inhibitors of prostaglandin E (PGE) production but was partially reduced by a [beta]-adrenergic blocker. These results demonstrate that BRS-3 has a role in body temperature regulation, presumably secondary to its effect on energy metabolism, including effects on sympathetic tone. By making use of this phenomenon, the reversal of the fasting [T.sub.b] reduction was developed into a sensitive single-dose pharmacodynamic assay for BRS-3 agonism and other antiobesity compounds acting by various mechanisms, including sibutramine, cannabinoid-1, and melanin-concentrating hormone-1 receptor blockers, and melanocortin, [[beta].sub.3]-adrenergic, and cholecystokinin-1 receptor agonists. These drugs increased both the fasted [T.sub.b] and the fasted, resting metabolic rates. The [T.sub.b] assay is a robust, information-rich assay that is simpler and has a greater throughput than measuring metabolic rate and is a practical, effective tool for drug discovery. tachyphylaxis; metabolic rate; thermoregulation; fasting; drug discovery doi: 10.1152/ajpendo.00404.2010.

Published
2010

12. Molecular basis of the pharmacological difference between rat and human bombesin receptor subtype-3 (BRS-3)

Author

Liu, Jie, Lao, Zhege J., Zhang, Jiaping, Schaeffer, M. T., Jiang, Michael M., Guan, Xiao-Ming, Van Der Ploeg, Lex H. T., and Fong, Tung M.

Subjects
Biochemistry -- Research, Molecules -- Physiological aspects, Bombesin -- Genetic aspects, Proteins -- Receptors, Messenger RNA -- Genetic aspects, Cloning -- Genetic aspects, Gene expression -- Physiological aspects, DNA -- Genetic aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on the rat bombesin receptor subtype-3 (BRS-3). The cloning of the cDNA and gene for this receptor and the characterization of its mRNA expression pattern have bee carried out and the results indicate the existence of pharmacological difference between human and rat BRS-3.

Published
2002

17. Identification of receptors for neuromedin U and its role in feeding

Author

Howard, Andrew D., Wang, Ruiping, Pong, Sheng-Shung, Mellin, Theodore N., Strack, Alison, Guan, Xiao-Ming, Zeng, Zhizhen, Williams, Jr, David L., Feighner, Scott D., Nunes, Christian N., Murphy, Beth, Stair, Judith N., Yu, Hong, Jiang, Qingping, Clements, Michelle K., Tan, Carina P., McKee, Karen K., Hreniuk, Donna L., McDonald, Terrence P., Lynch, Kevin R., Evans, Jilly F., Austin, Christopher P., Caskey, C. Thomas, Van der Ploeg, Lex H. T., and Liu, Qingyun

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Andrew D. Howard [1, 2]; Ruiping Wang [3, 2]; Sheng-Shung Pong [1]; Theodore N. Mellin [4]; Alison Strack [4]; Xiao-Ming Guan [1]; Zhizhen Zeng [3]; David L. Williams, Jr [...]

Published
2000
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21. Precision Surgery for Placenta Previa Complicated with Placenta Percreta

Author

Chen, Juan-Juan, primary, Yu, Lin, additional, Su, Chun-Hong, additional, Zhang, Chun-Fang, additional, Chen, Yan-Hong, additional, Zhou, Yan-Mei, additional, He, Wen-Jun, additional, He, Fang, additional, Song, Ting, additional, Wang, Shou-Ping, additional, Su, Zhi-Yuan, additional, Jiang, Qing-Ping, additional, Zou, Zi-Hao, additional, Yu, Bin, additional, Shen, Xiao-Ya, additional, Guan, Xiao-Ming, additional, and Chen, Dun-Jin, additional

Published
2019
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22. A Selective Human beta3 Adrenergic Receptor Agonist Increases Metabolic Rate in Rhesus Monkeys

Author

Fisher, Michael H., Amend, Angela M., Bach, Thomas J., Barker, Jeanne M., Brady, Edward J., Candelore, Mari R., Carroll, Dayna, Cascieri, Margaret A., Chiu, Shuet-Hing Lee, Deng, Liping, Forrest, Michael J., Hegarty-Friscino, Bonnie, Guan, Xiao-Ming, Hom, Gary J., Hutchins, Jennifer E., Kelly, Linda J., Mathvink, Robert J., Metzger, Joseph M., Miller, Randall R., Ok, Hyun O., Parmee, Emma R., Saperstein, Richard, Strader, Catherine D., Stearns, Ralph A., Thompson, G. Marie, Tota, Laurie, Vicario, Pasquale P., Weber, Ann E., Woods, John W., Wyvratt, Matthew J., Zafian, Peter T., and MacIntyre, D. Euan

Published
1998

24. Cis-2-dodecenoic Acid Mediates Its Synergistic Effect with Triazoles by Interfering with Efflux Pumps in Fluconazole-resistant Candida albicans.

Author

YANG, Dong Liang, HU, Yan Ling, YIN, Zi Xin, ZENG, Gui Sheng, LI, Dan, ZHANG, Yu Qian, XU, Zhen Hua, GUAN, Xiao Ming, WENG, Li Xing, and WANG, Lian Hui

Subjects
ITRACONAZOLE, CANDIDA albicans, TRIAZOLES, CANDIDIASIS, POLYMERASE chain reaction, PUMPING machinery
Abstract

To evaluate the synergy of the Burkholderia signaling molecule cis -2-dodecenoic acid (BDSF) and fluconazole (FLU) or itraconazole (ITRA) against two azole-resistant C. albicans clinical isolates in vitro and in vivo. Minimum inhibitory concentrations (MICs) of antibiotics against two azole-resistant C. albicans were measured by the checkerboard technique, E-test, and time-kill assay. In vivo antifungal synergy testing was performed on mice. Analysis of the relative gene expression levels of the strains was conducted by quantitative reverse-transcription polymerase chain reaction (qRT-PCR). BDSF showed highly synergistic effects in combination with FLU or ITRA with a fractional inhibitory concentration index of ≤ 0.08. BDSF was not cytotoxic to normal human foreskin fibroblast cells at concentrations of up to 300 µg/mL. The qRT-PCR results showed that the combination of BDSF and FLU/ITRA significantly inhibits the expression of the efflux pump genes CDR1 and MDR1 via suppression of the transcription factors TAC1 and MRR1 , respectively, when compared with FLU or ITRA alone. No dramatic difference in the mRNA expression levels of ERG1 , ERG11 , and UPC2 was found, which indicates that the drug combinations do not significantly interfere with UPC2 -mediated ergosterol levels. In vivo experiments revealed that combination therapy can be an effective therapeutic approach to treat candidiasis. The synergistic effects of BDSF and azoles may be useful as an alternative approach to control azole-resistant Candida infections. [ABSTRACT FROM AUTHOR]

Published
2019
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27. Synthesis and SAR of heterocyclic carboxylic acid isosteres based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity

Author

Hadden, Mark, Goodman, Allan, Guo, Cheng, Guzzo, Peter R., Henderson, Alan J., Pattamana, Kevin, Ruenz, Megan, Sargent, Bruce J., Swenson, Brian, Yet, Larry, Liu, Jian, He, Shuwen, Sebhat, Iyassu K., Lin, Linus S., Tamvakopoulos, Constantin, Peng, Qianping, Kan, Yanqing, Palyha, Oksana, Kelly, Theresa M., Guan, Xiao-Ming, Metzger, Joseph M., Reitman, Marc L., and Nargund, Ravi P.

Published
2010
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28. Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity

Author

Liu, Jian, He, Shuwen, Jian, Tianying, Dobbelaar, Peter H., Sebhat, Iyassu K., Lin, Linus S., Goodman, Allan, Guo, Cheng, Guzzo, Peter R., Hadden, Mark, Henderson, Alan J., Pattamana, Kevin, Ruenz, Megan, Sargent, Bruce J, Swenson, Brian, Yet, Larry, Tamvakopoulos, Constantin, Peng, Qianping, Pan, Jie, Kan, Yanqing, Palyha, Oksana, Kelly, Theresa M., Guan, Xiao-Ming, Howard, Andrew D., Marsh, Donald J., Metzger, Joseph M., Reitman, Marc L., Wyvratt, Matthew J., and Nargund, Ravi P.

Published
2010
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29. Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists

Author

He, Shuwen, Dobbelaar, Peter H., Liu, Jian, Jian, Tianying, Sebhat, Iyassu K., Lin, Linus S., Goodman, Allan, Guo, Cheng, Guzzo, Peter R., Hadden, Mark, Henderson, Alan J., Ruenz, Megan, Sargent, Bruce J., Yet, Larry, Kelly, Theresa M., Palyha, Oksana, Kan, Yanqing, Pan, Jie, Chen, Howard, Marsh, Donald J., Shearman, Lauren P., Strack, Alison M., Metzger, Joseph M., Feighner, Scott D., Tan, Carina, Howard, Andrew D., Tamvakopoulos, Constantin, Peng, Qianping, Guan, Xiao-Ming, Reitman, Marc L., Patchett, Arthur A., Wyvratt, Matthew J., Jr., and Nargund, Ravi P.

Published
2010
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30. Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity

Author

Chobanian, Harry R., primary, Guo, Yan, additional, Liu, Ping, additional, Chioda, Marc, additional, Lanza, Thomas J., additional, Chang, Linda, additional, Kelly, Theresa M., additional, Kan, Yanqing, additional, Palyha, Oksana, additional, Guan, Xiao-Ming, additional, Marsh, Donald J., additional, Metzger, Joseph M., additional, Gorski, Judith N., additional, Raustad, Kate, additional, Wang, Sheng-Ping, additional, Strack, Alison M., additional, Miller, Randy, additional, Pang, Jianmei, additional, Madeira, Maria, additional, Lyons, Kathy, additional, Dragovic, Jasminka, additional, Reitman, Marc L., additional, Nargund, Ravi P., additional, and Lin, Linus S., additional

Published
2012
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31. Discovery of Benzodiazepine Sulfonamide-Based Bombesin Receptor Subtype 3 Agonists and Their Unusual Chirality

Author

Liu, Ping, primary, Lanza, Thomas J., additional, Chioda, Marc, additional, Jones, Carrie, additional, Chobanian, Harry R., additional, Guo, Yan, additional, Chang, Linda, additional, Kelly, Theresa M., additional, Kan, Yanqing, additional, Palyha, Oksana, additional, Guan, Xiao-Ming, additional, Marsh, Donald J., additional, Metzger, Joseph M., additional, Ramsay, Katie, additional, Wang, Sheng-Ping, additional, Strack, Alison M., additional, Miller, Randy, additional, Pang, Jianmei, additional, Lyons, Kathy, additional, Dragovic, Jasminka, additional, Ning, Jian G., additional, Schafer, Wes A., additional, Welch, Christopher J., additional, Gong, Xiaoyi, additional, Gao, Ying-Duo, additional, Hornak, Viktor, additional, Ball, Richard G., additional, Tsou, Nancy, additional, Reitman, Marc L., additional, Wyvratt, Matthew J., additional, Nargund, Ravi P., additional, and Lin, Linus S., additional

Published
2011
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34. Antiobesity Effect of MK-5046, a Novel Bombesin Receptor Subtype-3 Agonist

Author

Guan, Xiao-Ming, primary, Metzger, Joseph M., additional, Yang, Liming, additional, Raustad, Kate A., additional, Wang, Sheng-Ping, additional, Spann, Stephanie K., additional, Kosinski, Jennifer A., additional, Yu, Hong, additional, Shearman, Lauren P., additional, Faidley, Terry D., additional, Palyha, Oksana, additional, Kan, Yanqing, additional, Kelly, Theresa M., additional, Sebhat, Iyassu, additional, Lin, Linus S., additional, Dragovic, Jasminka, additional, Lyons, Kathy A., additional, Craw, Stephanie, additional, Nargund, Ravi P., additional, Marsh, Donald J., additional, Strack, Alison M., additional, and Reitman, Marc L., additional

Published
2010
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35. Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity

Author

Sebhat, Iyassu K., primary, Franklin, Christopher, additional, Lo, Michael M.-C., additional, Chen, David, additional, Jewell, James P., additional, Miller, Randy, additional, Pang, Jianmei, additional, Palyha, Oksana, additional, Kan, Yanqing, additional, Kelly, Theresa M., additional, Guan, Xiao-Ming, additional, Marsh, Donald J., additional, Kosinski, Jennifer A., additional, Metzger, Joseph M., additional, Lyons, Kathryn, additional, Dragovic, Jasminka, additional, Guzzo, Peter R., additional, Henderson, Alan J., additional, Reitman, Marc L., additional, Nargund, Ravi P., additional, Wyvratt, Matthew J., additional, and Lin, Linus S., additional

Published
2010
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36. Antiobesity Efficacy of a Novel Cannabinoid-1 Receptor Inverse Agonist, N-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), in Rodents

Author

Fong, Tung M., primary, Guan, Xiao-Ming, additional, Marsh, Donald J., additional, Shen, Chun-Pyn, additional, Stribling, D. Sloan, additional, Rosko, Kim M., additional, Lao, Julie, additional, Yu, Hong, additional, Feng, Yue, additional, Xiao, Jing C., additional, Van der Ploeg, Lex H. T., additional, Goulet, Mark T., additional, Hagmann, Williams K., additional, Lin, Linus S., additional, Lanza, Thomas J., additional, Jewell, James P., additional, Liu, Ping, additional, Shah, Shrenik K., additional, Qi, Hongbo, additional, Tong, Xinchun, additional, Wang, Junying, additional, Xu, Suoyu S., additional, Francis, Barbara, additional, Strack, Alison M., additional, MacIntyre, D. Euan, additional, and Shearman, Lauren P., additional

Published
2007
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37. α-Melanocyte-Stimulating Hormone Stimulates Oxytocin Release from the Dendrites of Hypothalamic Neurons While Inhibiting Oxytocin Release from Their Terminals in the Neurohypophysis

Author

Sabatier, Nancy, primary, Caquineau, Céline, additional, Dayanithi, Govindan, additional, Bull, Philip, additional, Douglas, Alison J., additional, Guan, Xiao Ming M., additional, Jiang, Michael, additional, Van der Ploeg, Lex, additional, and Leng, Gareth, additional

Published
2003
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39. Melanin-Concentrating Hormone Receptor Subtypes 1 and 2: Species-Specific Gene Expression

Author

Tan, Carina P., primary, Sano, Hideki, additional, Iwaasa, Hisashi, additional, Pan, Jie, additional, Sailer, Andreas W., additional, Hreniuk, Donna L., additional, Feighner, Scott D., additional, Palyha, Oksana C., additional, Pong, Sheng-Shung, additional, Figueroa, David J., additional, Austin, Christopher P., additional, Jiang, Michael M., additional, Yu, Hong, additional, Ito, Junko, additional, Ito, Makoto, additional, Ito, Masahiko, additional, Guan, Xiao Ming, additional, MacNeil, Douglas J., additional, Kanatani, Akio, additional, Van der Ploeg, Lex H.T., additional, and Howard, Andrew D., additional

Published
2002
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40. Identification and Characterization of Novel Mammalian Neuropeptide FF-like Peptides That Attenuate Morphine-induced Antinociception

Author

Liu, Qingyun, primary, Guan, Xiao-Ming, additional, Martin, William J., additional, McDonald, Terrence P., additional, Clements, Michelle K., additional, Jiang, Qingping, additional, Zeng, Zhizhen, additional, Jacobson, Marlene, additional, Williams, David L., additional, Yu, Hong, additional, Bomford, Douglas, additional, Figueroa, David, additional, Mallee, John, additional, Wang, Ruiping, additional, Evans, Jilly, additional, Gould, Robert, additional, and Austin, Christopher P., additional

Published
2001
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43. Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

Author

Chen, Airu S., primary, Marsh, Donald J., additional, Trumbauer, Myrna E., additional, Frazier, Easter G., additional, Guan, Xiao-Ming, additional, Yu, Hong, additional, Rosenblum, Charles I., additional, Vongs, Aurawan, additional, Feng, Yue, additional, Cao, Linhai, additional, Metzger, Joseph M., additional, Strack, Alison M., additional, Camacho, Ramon E., additional, Mellin, Theodore N., additional, Nunes, Christian N., additional, Min, William, additional, Fisher, Jill, additional, Gopal-Truter, Shobhna, additional, MacIntyre, D. Euan, additional, Chen, Howard Y., additional, and Van der Ploeg, Lex H.T., additional

Published
2000
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