599 results on '"GU Lian-Quan"'
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2. Identification of small molecules capable of regulating conformational changes of telomeric G-quadruplex
3. Interaction of Quindoline derivative with telomeric repeat–containing RNA induces telomeric DNA-damage response in cancer cells through inhibition of telomeric repeat factor 2
4. Curcusone C induces telomeric DNA-damage response in cancer cells through inhibition of telomeric repeat factor 2
5. Syntheses and antibacterial activity of soluble 9-bromo substituted indolizinoquinoline-5,12-dione derivatives
6. Accurate high-throughput identification of parallel G-quadruplex topology by a new tetraaryl-substituted imidazole
7. A simple structural modification to thiazole orange to improve the selective detection of G-quadruplexes
8. Synthesis and biological evaluation of 6-substituted indolizinoquinolinediones as catalytic DNA topoisomerase I inhibitors
9. Discovery of natural alkaloid bouchardatine as a novel inhibitor of adipogenesis/lipogenesis in 3T3-L1 adipocytes
10. Design, synthesis and biological evaluation of novel 7-alkylamino substituted benzo[a]phenazin derivatives as dual topoisomerase I/II inhibitors
11. Design, synthesis, and biological evaluation of 2-arylethenylquinoline derivatives as multifunctional agents for the treatment of Alzheimer's disease
12. Mechanistic studies on the anticancer activity of 2,4-disubstituted quinazoline derivative
13. Stabilization of VEGF G-quadruplex and inhibition of angiogenesis by quindoline derivatives
14. Synthesis and characterization of 1H-phenanthro[9,10-d]imidazole derivatives as multifunctional agents for treatment of Alzheimer's disease
15. Synthesis and evaluation of new BODIPY-benzofuroquinoline conjugates for sensitive and selective DNA detection
16. G-quadruplex-mediated regulation of telomere binding protein POT1 gene expression
17. Cellular nucleic acid binding protein suppresses tumor cell metastasis and induces tumor cell death by downregulating heterogeneous ribonucleoprotein K in fibrosarcoma cells
18. Syntheses and characterization of non-bisphosphonate quinoline derivatives as new FPPS inhibitors
19. Syntheses of diacyltanshinol derivatives and their suppressive effects on macrophage foam cell formation by reducing oxidized LDL uptake
20. The role of positive charges on G-quadruplex binding small molecules: Learning from bisaryldiketene derivatives
21. G-Quadruplex conformational change driven by pH variation with potential application as a nanoswitch
22. Mechanistic studies for the role of cellular nucleic-acid-binding protein (CNBP) in regulation of c-myc transcription
23. Design, synthesis and biological evaluation of novel mansonone E derivatives prepared via CuAAC click chemistry as topoisomerase II inhibitors
24. Syntheses, spectroscopic characterization and application to DNA determination of novel fluorescent pyridophenazine derivatives
25. Syntheses and evaluation of novel isoliquiritigenin derivatives as potential dual inhibitors for amyloid-beta aggregation and 5-lipoxygenase
26. Facile syntheses of disubstituted bis(vinylquinolinium)benzene derivatives as G-quadruplex DNA binders
27. Synthesis and evaluation of 7,8-dehydrorutaecarpine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease
28. New quinazoline derivatives for telomeric G-quadruplex DNA: Effects of an added phenyl group on quadruplex binding ability
29. 3D-QSAR studies of azaoxoisoaporphine, oxoaporphine, and oxoisoaporphine derivatives as anti-AChE and anti-AD agents by the CoMFA method
30. 12-N-Methylated 5,6-dihydrobenzo[c]acridine derivatives: A new class of highly selective ligands for c-myc G-quadruplex DNA
31. Disubstituted 1,8-dipyrazolcarbazole derivatives as a new type of c-myc G-quadruplex binding ligands
32. Design, synthesis and evaluation of isaindigotone derivatives as dual inhibitors for acetylcholinesterase and amyloid beta aggregation
33. Disubstituted quinazoline derivatives as a new type of highly selective ligands for telomeric G-quadruplex DNA
34. Design, synthesis, and biological evaluation of curcumin analogues as multifunctional agents for the treatment of Alzheimer’s disease
35. Synthesis and evaluation of heterobivalent tacrine derivatives as potential multi-functional anti-Alzheimer agents
36. Syntheses and characterization of nimesulide derivatives for dual enzyme inhibitors of both cyclooxygenase-1/2 and 5-lipoxygenase
37. Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as dual inhibitors for cholinesterases and amyloid beta aggregation
38. Synthesis, antimicrobial activity and possible mechanism of action of 9-bromo-substituted indolizinoquinoline-5,12-dione derivatives
39. Synthesis and evaluation of mansonone F derivatives as topoisomerase inhibitors
40. Syntheses and characterization of novel oxoisoaporphine derivatives as dual inhibitors for cholinesterases and amyloid beta aggregation
41. Bisaryldiketene derivatives: A new class of selective ligands for c-myc G-quadruplex DNA
42. Synthesis and evaluation of graveoline and graveolinine derivatives with potent anti-angiogenesis activities
43. Synthesis and antiproliferative activity of indolizinophthalazine-5,12-dione derivatives, DNA topoisomerase IB inhibitors
44. Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors
45. Chemical intervention of the NM23-H2 transcriptional programme on c-MYC via a novel small molecule
46. Natural tanshinone-like heterocyclic-fused ortho-quinones from regioselective Diels–Alder reaction: Synthesis and cytotoxicity evaluation
47. Synthesis, biological evaluation and molecular modeling of oxoisoaporphine and oxoaporphine derivatives as new dual inhibitors of acetylcholinesterase/butyrylcholinesterase
48. Inhibition of thioredoxin reductase by mansonone F analogues: Implications for anticancer activity
49. New insights from molecular dynamic simulation studies of the multiple binding modes of a ligand with G-quadruplex DNA
50. Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitors
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