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103 results on '"GRIFFITHS, G. M."'

3. Structure and Biogenesis of Lytic Granules

Author

Griffiths, G. M., Argon, Y., Capron, A., editor, Compans, R. W., editor, Cooper, M., editor, Koprowski, H., editor, McConnell, I., editor, Melchers, F., editor, Oldstone, M., editor, Olsnes, S., editor, Potter, M., editor, Saedler, H., editor, Vogt, P. K., editor, Wagner, H., editor, Wilson, I., editor, Griffiths, Gillian M., editor, and Tschopp, Jürg, editor

Published
1995
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9. Forecasting brown haze in Auckland.

Author

Griffiths, G. M., Talbot, N., Dirks, K. N., Betti, G., and Salmond., J. A.

Subjects
*HAZE, *ATMOSPHERIC brown clouds, *AIR quality, URBAN ecology (Sociology)
Abstract

Brown haze is a visual indicator of poor urban air quality. In Auckland, brown haze typically occurs on cold winter days during the weekday morning commute. There is large interannual variability in the number of brown haze events observed in the region. Recent research identified a clear link between brown haze and poor respiratory health outcomes in Auckland. This paper analyses the meteorological characteristics of 23 brown haze events in Auckland (as identified from camera images) and proposes a simple Numerical Weather Prediction (NWP) forecast scheme that doesn't explicitly model pollutants, but instead predicts weather conditions historically conducive to brown haze. Results showed a distinctive atmospheric profile associated with the development of brown haze conditions. A forecast scheme was designed to capture this specific meteorology, and was subsequently validated against camera imagery during a pilot phase lasting three months during the winter of 2017, both at the 30-hour and 54-hour forecast validity period. Results showed 97% forecast accuracy for both 30- and 54-hour forecasts, and a probability of detection of 89% and 78% respectively. One limitation of the current forecast scheme is that it does not forecast local emissions, and so does not differentiate between weekdays and weekends. Human assessment would still be required before forecasts could be released to the public. Another limitation is that validating the scheme is subjective (brown haze is a visual indicator). Future work will validate the forecast scheme against quantitative measurements of surface air pollution concentrations over a longer period (3 winters), since initial relationships between the forecast index and observed air pollution concentrations looked promising. [ABSTRACT FROM AUTHOR]

Published
2019
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10. Genetic predisposition to hemophagocytic lymphohistiocytosis: Report on 500 patients from the Italian registry

Author

Cetica, V., Sieni, E., Pende, D., Danesino, C., De Fusco, C., Locatelli, Franco, Micalizzi, C., Putti, M. C., Biondi, A., Fagioli, F., Moretta, L., Griffiths, G. M., Luzzatto, L., Arico, M., Locatelli F. (ORCID:0000-0002-7976-3654), Cetica, V., Sieni, E., Pende, D., Danesino, C., De Fusco, C., Locatelli, Franco, Micalizzi, C., Putti, M. C., Biondi, A., Fagioli, F., Moretta, L., Griffiths, G. M., Luzzatto, L., Arico, M., and Locatelli F. (ORCID:0000-0002-7976-3654)

Abstract

Background Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening disease affecting mostly children but also adults and characterized by hyperinflammatory features. A subset of patients, referred to as having familial hemophagocytic lymphohistiocytosis (FHL), have various underlying genetic abnormalities, the frequencies of which have not been systematically determined previously. Objective This work aims to further our understanding of the pathogenic bases of this rare condition based on an analysis of our 25 years of experience. Methods From our registry, we have analyzed a total of 500 unselected patients with HLH. Results Biallelic pathogenic mutations defining FHL were found in 171 (34%) patients; the proportion of FHL was much higher (64%) in patients given a diagnosis during the first year of life. Taken together, mutations of the genes PRF1 (FHL2) and UNC13D (FHL3) accounted for 70% of cases of FHL. Overall, a genetic diagnosis was possible in more than 90% of our patients with FHL. Perforin expression and the extent of degranulation have been more useful for diagnosing FHL than hemophagocytosis and the cytotoxicity assay. Of 281 (56%) patients classified as having "sporadic" HLH, 43 had monoallelic mutations in one of the FHL-defining genes. Given this gene dosage effect, FHL is not strictly recessive. Conclusion We suggest that the clinical syndrome HLH generally results from the combined effects of an exogenous trigger and genetic predisposition. Within this combination, different weights of exogenous and genetic factors account for the wide disease spectrum that ranges from HLH secondary to severe infection to FHL.

Published
2016

12. STATE OF THE CLIMATE IN 2011 Special Supplement to the Bulletin of the American Meteorological Society Vol. 93, No. 7, July 2012

Author

Arndt, D. S., Blunden, J., Willett, K. M., Dolman, A. J., Hall, B. D., Thorne, P. W., Gregg, M. C., Newlin, M. L., Xue, Y., Hu, Z., Kumar, A., Banzon, V., Smith, T. M., Rayner, N. A., Jeffries, M. O., Richter-Menge, J., Overland, J., Bhatt, U., Key, J., Liu, Y., Walsh, J., Wang, M., Fogt, R. L., Scambos, T. A., Wovrosh, A. J., Barreira, S., Sanchez-Lugo, A., Renwick, J. A., Thiaw, W. M., Weaver, S. J., Whitewood, R., Phillips, D., Achberger, C., Ackerman, S. A., Ahmed, F. H., Albanil-Encarnacion, A., Alfaro, E. J., Alves, L. M., Allan, R., Amador, J. A., Ambenje, P., Antoine, M. D., Antonov, J., Arevalo, J., Ashik, I., Atheru, Z., Baccini, A., Baez, J., Baringer, M. O., Barriopedro, D. E., Bates, J. J., Becker, A., Behrenfeld, M. J., Bell, G. D., Benedetti, A., Bernhard, G., Berrisford, P., Berry, D. I., Beszczynska-Moeller, A., Bhatt, U. S., Bidegain, M., Bieniek, P., Birkett, C., Bissolli, P., Blake, E. S., Boudet-Rouco, D., Box, J. E., Boyer, T., Braathen, G. O., Brackenridge, G. R., Brohan, P., Bromwich, D. H., Brown, L., Brown, R., Bruhwiler, L., Bulygina, O. N., Burrows, J., Calderon, B., Camargo, S. J., Cappellen, J., Carmack, E., Carrasco, G., Chambers, D. P., Christiansen, H. H., Christy, J., Chung, D., Ciais, P., Coehlo, C. A. S., Colwell, S., Comiso, J., Cretaux, J. F., Crouch, J., Cunningham, S. A., Jeu, R. A. M., Demircan, M., Derksen, C., Diamond, H. J., Dlugokencky, E. J., Dohan, K., Dorigo, W. A., Drozdov, D. S., Duguay, C., Dutton, E., Dutton, G. S., Elkins, J. W., Epstein, H. E., Famiglietti, J. S., Fanton D Andon, O. H., Feely, R. A., Fekete, B. M., Fenimore, C., Fernandez-Prieto, D., Fields, E., Fioletov, V., Folland, C., Foster, M. J., Frajka-Williams, E., Franz, B. A., Frey, K., Frith, S. H., Frolov, I., Frost, G. V., Ganter, C., Garzoli, S., Gitau, W., Gleason, K. L., Gobron, N., Goldenberg, S. B., Goni, G., Gonzalez-Garcia, I., Gonzalez-Rodriguez, N., Good, S. A., Goryl, P., Gottschalck, J., Gouveia, C. M., Griffiths, G. M., Grigoryan, V., Grooss, J. U., Guard, C., Guglielmin, M., Halpert, M. S., Heidinger, A. K., Heikkila, A., Heim, R. R., Hennon, P. A., Hidalgo, H. G., Hilburn, K., Ho, S. P., Hobbs, W. R., Holgate, S., Hook, S. J., Hovsepyan, A., Hu, Z. Z., Hugony, S., Hurst, D. F., Ingvaldsen, R., Itoh, M., Jaimes, E., Jeffries, M., Johns, W. E., Johnsen, B., Johnson, B., Johnson, G. C., Jones, L. T., Jumaux, G., Kabidi, K., Kaiser, J. W., Kang, K. K., Kanzow, T. O., Kao, H. Y., Keller, L. M., Kendon, M., Kennedy, J. J., Kervankiran, S., Khatiwala, S., Kholodov, A. L., Khoshkam, M., Kikuchi, T., Kimberlain, T. B., King, D., Knaff, J. A., Korshunova, N. N., Koskela, T., Kratz, D. P., Krishfield, R., Kruger, A., Kruk, M. C., Lagerloef, G., Lakkala, K., Lammers, R. B., Lander, M. A., Landsea, C. W., Lankhorst, M., Lapinel-Pedroso, B., Lazzara, M. A., Leduc, S., Lefale, P., Leon, G., Leon-Lee, A., Leuliette, E., Levitus, S., L Heureux, M., Lin, II, Liu, H. X., Liu, Y. J., Lobato-Sanchez, R., Locarnini, R., Loeb, N. G., Loeng, H., Long, C. S., Lorrey, A. M., Lumpkin, R., Myhre, C. L., Jing-Jia Luo, Lyman, J. M., Maccallum, S., Macdonald, A. M., Maddux, B. C., Manney, G., Marchenko, S. S., Marengo, J. A., Maritorena, S., Marotzke, J., Marra, J. J., Martinez-Sanchez, O., Maslanik, J., Massom, R. A., Mathis, J. T., Mcbride, C., Mcclain, C. R., Mcgrath, D., Mcgree, S., Mclaughlin, F., Mcvicar, T. R., Mears, C., Meier, W., Meinen, C. S., Menendez, M., Merchant, C., Merrifield, M. A., Miller, L., Mitchum, G. T., Montzka, S. A., Moore, S., Mora, N. P., Morcrette, J. J., Mote, T., Muhle, J., Mullan, A. B., Muller, R., Myhre, C., Nash, E. R., Nerem, R. S., Newman, P. A., Ngari, A., Nishino, S., Njau, L. N., Noetzli, J., Oberman, N. G., Obregon, A., Ogallo, L., Oludhe, C., Oyunjargal, L., Parinussa, R. M., Park, G. H., Parker, D. E., Pasch, R. J., Pascual-Ramirez, R., Pelto, M. S., Penalba, O., Perez-Suarez, R., Perovich, D., Pezza, A. B., Pickart, R., Pinty, B., Pinzon, J., Pitts, M. C., Pour, H. K., Prior, J., Privette, J. L., Proshutinsky, A., Quegan, S., Quintana, J., Rabe, B., Rahimzadeh, F., Rajeevan, M., Rayner, D., Raynolds, M. K., Razuvaev, V. N., Reagan, J., Reid, P., Revadekar, J., Rex, M., Rivera, I. L., Robinson, D. A., Rodell, M., Roderick, M. L., Romanovsky, V. E., Ronchail, J., Rosenlof, K. H., Rudels, B., Sabine, C. L., Santee, M. L., Sawaengphokhai, P., Sayouri, A., Schauer, U., Schemm, J., Schmid, C., Schreck, C., Semiletov, I., Send, U., Sensoy, S., Shakhova, N., Sharp, M., Shiklomanov, N. I., Shimada, K., Shin, J., Siegel, D. A., Simmons, A., Skansi, M., Sokolov, V., Spence, J., Srivastava, A. K., Stackhouse, P. W., Stammerjohn, S., Steele, M., Steffen, K., Steinbrecht, W., Stephenson, T., Stolarski, R. S., Sweet, W., Takahashi, T., Taylor, M. A., Tedesco, M., Thepaut, J. N., Thompson, P., Timmermans, M. L., Tobin, S., Toole, J., Trachte, K., Trewin, B. C., Trigo, R. M., Trotman, A., Tucker, C. J., Ulupinar, Y., Wal, R. S. W., Werf, G. R., Vautard, R., Votaw, G., Wagner, W. W., Wahr, J., Walker, D. A., Wang, C. Z., Wang, J. H., Wang, L., Wang, M. H., Wang, S. H., Wanninkhof, R., Weaver, S., Weber, M., Weingartner, T., Weller, R. A., Wentz, F., Wilber, A. C., Williams, W., Willis, J. K., Wilson, R. C., Wolken, G., Wong, T. M., Woodgate, R., Yamada, R., Yamamoto-Kawai, M., Yoder, J. A., Yu, L. S., Yueh, S., Zhang, L. Y., Zhang, P. Q., Zhao, L., Zhou, X. J., Zimmermann, S., Zubair, L., Laboratoire d'études en Géophysique et océanographie spatiales (LEGOS), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), National Oceanic and Atmospheric Administration (NOAA), Lamont-Doherty Earth Observatory (LDEO), Columbia University [New York], Space Technology Center, European Centre for Medium-Range Weather Forecasts (ECMWF), Climate Research Division [Toronto], Environment and Climate Change Canada, Earth and Space Research Institute [Seattle] (ESR), Department of Hydrology and Geo-Environmental Sciences [Amsterdam], Vrije Universiteit Amsterdam [Amsterdam] (VU), Vienna University of Technology (TU Wien), Instituto Dom Luiz, Universidade de Lisboa = University of Lisbon (ULISBOA), NOAA Earth System Research Laboratory (ESRL), Cooperative Institute for Research in Environmental Sciences (CIRES), University of Colorado [Boulder]-National Oceanic and Atmospheric Administration (NOAA), Department of Earth System Science [Irvine] (ESS), University of California [Irvine] (UC Irvine), University of California (UC)-University of California (UC), Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), University of California Center for Hydrologic Modeling [Irvine] (UCCHM), NOAA Pacific Marine Environmental Laboratory [Seattle] (PMEL), Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Extrèmes : Statistiques, Impacts et Régionalisation (ESTIMR), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Department of Physics [Boulder], University of Colorado [Boulder], Istituto Nazionale di Fisica Nucleare [Pisa] (INFN), Istituto Nazionale di Fisica Nucleare (INFN), NOAA Atlantic Oceanographic and Meteorological Laboratory (AOML), University at Albany [SUNY], State University of New York (SUNY), Cooperative Institute for Meteorological Satellite Studies (CIMSS), University of Wisconsin-Madison-NASA-National Oceanic and Atmospheric Administration (NOAA), Peking University [Beijing], National Oceanography Centre [Southampton] (NOC), University of Southampton, NOAA National Environmental Satellite, Data, and Information Service (NESDIS), The University of Texas Medical Branch (UTMB), Institut für Umweltphysik [Bremen] (IUP), Universität Bremen, Department of Meteorology, University of Nairobi (UoN), Climate Prediction and Applications Centre (ICPAC), IGAD, Institute for Environment and Sustainability of the JRC, Partenaires INRAE, Met Office Hadley Centre for Climate Change (MOHC), United Kingdom Met Office [Exeter], Agricultural Information Institute (AII), Chinese Academy of Agricultural Sciences (CAAS), Woods Hole Oceanographic Institution (WHOI), Universitá degli Studi dell’Insubria = University of Insubria [Varese] (Uninsubria), Heilongjiang Institute of Science and Technology, Finnish Meteorological Institute (FMI), Universidad de Costa Rica (UCR), University Corporation for Atmospheric Research (UCAR), NOAA Center for Satellite Applications and Research (STAR), National Oceanic and Atmospheric Administration (NOAA)-National Oceanic and Atmospheric Administration (NOAA), ESRL Global Monitoring Laboratory [Boulder] (GML), Materials and structures Laboratory, Tokyo Institute of Technology [Tokyo] (TITECH), Rosenstiel School of Marine and Atmospheric Science (RSMAS), University of Miami [Coral Gables], Norwegian Radiation and Nuclear Safety Authority, Direction Interrégionale de Météo-France pour l'océan Indien (DIROI), Météo-France, Department of Earth Sciences [Oxford], University of Oxford, NASA Langley Research Center [Hampton] (LaRC), University of Hawai‘i [Mānoa] (UHM), Department of Earth and Space Sciences [Seattle], University of Washington [Seattle], Leibniz-Institut für Meereswissenschaften (IFM-GEOMAR), Scripps Institution of Oceanography (SIO - UC San Diego), University of California [San Diego] (UC San Diego), Agroécologie [Dijon], Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Huazhong Agricultural University [Wuhan] (HZAU), NOAA National Weather Service (NWS), Department of Oceanography, Florida State University [Tallahassee] (FSU), Norwegian Institute for Air Research (NILU), Research Institute for Global Change (RIGC), Japan Agency for Marine-Earth Science and Technology (JAMSTEC), NorthWest Research Associates (NWRA), Department of Physics [Socorro], New Mexico Institute of Mining and Technology [New Mexico Tech] (NMT), Ocean and Earth Science [Southampton], University of Southampton-National Oceanography Centre (NOC), Australian Antarctic Division (AAD), Australian Government, Department of the Environment and Energy, Antarctic Climate and Ecosystems Cooperative Research Centre (ACE-CRC), Massachusetts General Hospital [Boston], Commonwealth Scientific and Industrial Research Organisation [Canberra] (CSIRO), Australian Research Council (ARC), Remote Sensing Systems [Santa Rosa] (RSS), Développement, institutions et analyses de long terme (DIAL), Université Paris Dauphine-PSL, Université Paris sciences et lettres (PSL), NOAA National Marine Fisheries Service (NMFS), University of California (UC), NMR Laboratory, Université de Mons, Université de Mons (UMons), NASA Goddard Space Flight Center (GSFC), Glaciology, Geomorphodynamics and Geochronology, Department of Geography [Zürich], Universität Zürich [Zürich] = University of Zurich (UZH)-Universität Zürich [Zürich] = University of Zurich (UZH), Chemistry Department [Massachusetts Institute of Technology], Massachusetts Institute of Technology (MIT), Nichols College Dudley, ERDC Cold Regions Research and Engineering Laboratory (CRREL), USACE Engineer Research and Development Center (ERDC), European Commission, Space Science and Engineering Center [Madison] (SSEC), University of Wisconsin-Madison, Lausanne University Hospital, Centro de Ciencias do Sistema Terrestre, Instituto Nacional de Pesquisas Espaciais (INPE), University of Sheffield, Hochschule Mannheim - University of Applied Sciences, Laboratoire d'océanographie de Villefranche (LOV), Observatoire océanologique de Villefranche-sur-mer (OOVM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Indian Institute of Tropical Meteorology (IITM), Ministry of Earth Sciences [India], Woods Hole Research Center, Department of Earth and Environment [Boston], Boston University [Boston] (BU), Centre for Australian Weather and Climate Research (CAWCR), Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung (AWI), Génétique et Ecologie des Virus, Génétique des Virus et Pathogénèse des Maladies Virales, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Botany and Plant Pathology, Oregon State University (OSU), Ctr Ecol & Hydrol, Bangor, Environm Ctr Wales, Biospherical Instruments Inc., Processus de la variabilité climatique tropicale et impacts (PARVATI), Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques (LOCEAN), Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université Paris Diderot - Paris 7 (UPD7), Instituto Uruguayo de Meteorología, Javier Barrios Amorín 1488, CP 11200, Montevideo, Uruguay, Science Systems and Applications, Inc. [Hampton] (SSAI), National Snow and Ice Data Center (NSIDC), Naval Postgraduate School (NPS), University of California [Berkeley] (UC Berkeley), Centre de physique moléculaire optique et hertzienne (CPMOH), Université Sciences et Technologies - Bordeaux 1 (UB)-Centre National de la Recherche Scientifique (CNRS), CYRIC, Tohoku University [Sendai], The University of Tennessee [Knoxville], Oak Ridge National Laboratory [Oak Ridge] (ORNL), UT-Battelle, LLC, The University Centre in Svalbard (UNIS), Institute of Arctic Alpine Research [University of Colorado Boulder] (INSTAAR), Swiss Federal Institute for Forest, Snow and Landscape Research WSL, Meteorologisches Observatorium Hohenpeißenberg (MOHp), Deutscher Wetterdienst [Offenbach] (DWD), British Antarctic Survey (BAS), Natural Environment Research Council (NERC), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Universidade de Lisboa (ULISBOA), University of California [Irvine] (UCI), University of California-University of California, Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Universitá degli Studi dell’Insubria, University of Costa Rica, Météo France [Sainte-Clotilde], Météo France, University of Oxford [Oxford], Scripps Institution of Oceanography (SIO), Huazhong Agricultural University, University of California, NMR and Molecular Imaging Laboratory [Mons], University of Mons [Belgium] (UMONS), Lausanne University Hospital [Switzerland], Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de la Mer de Villefranche (IMEV), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7), Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), Berkeley University of California (UC BERKELEY), Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1, and Institute of Arctic and Alpine Research (INSTAAR)

Subjects
[SDU.STU.OC]Sciences of the Universe [physics]/Earth Sciences/Oceanography
Abstract

International audience; Large-scale climate patterns influenced temperature and weather patterns around the globe in 2011. In particular, a moderate-to-strong La Nina at the beginning of the year dissipated during boreal spring but reemerged during fall. The phenomenon contributed to historical droughts in East Africa, the southern United States, and northern Mexico, as well the wettest two-year period (2010-11) on record for Australia, particularly remarkable as this follows a decade-long dry period. Precipitation patterns in South America were also influenced by La Nina. Heavy rain in Rio de Janeiro in January triggered the country's worst floods and landslides in Brazil's history. The 2011 combined average temperature across global land and ocean surfaces was the coolest since 2008, but was also among the 15 warmest years on record and above the 1981-2010 average. The global sea surface temperature cooled by 0.1 degrees C from 2010 to 2011, associated with cooling influences of La Nina. Global integrals of upper ocean heat content for 2011 were higher than for all prior years, demonstrating the Earth's dominant role of the oceans in the Earth's energy budget. In the upper atmosphere, tropical stratospheric temperatures were anomalously warm, while polar temperatures were anomalously cold. This led to large springtime stratospheric ozone reductions in polar latitudes in both hemispheres. Ozone concentrations in the Arctic stratosphere during March were the lowest for that period since satellite records began in 1979. An extensive, deep, and persistent ozone hole over the Antarctic in September indicates that the recovery to pre-1980 conditions is proceeding very slowly. Atmospheric carbon dioxide concentrations increased by 2.10 ppm in 2011, and exceeded 390 ppm for the first time since instrumental records began. Other greenhouse gases also continued to rise in concentration and the combined effect now represents a 30% increase in radiative forcing over a 1990 baseline. Most ozone depleting substances continued to fall. The global net ocean carbon dioxide uptake for the 2010 transition period from El Nino to La Nina, the most recent period for which analyzed data are available, was estimated to be 1.30 Pg C yr(-1), almost 12% below the 29-year long-term average. Relative to the long-term trend, global sea level dropped noticeably in mid-2010 and reached a local minimum in 2011. The drop has been linked to the La Nina conditions that prevailed throughout much of 2010-11. Global sea level increased sharply during the second half of 2011. Global tropical cyclone activity during 2011 was well-below average, with a total of 74 storms compared with the 1981-2010 average of 89. Similar to 2010, the North Atlantic was the only basin that experienced above-normal activity. For the first year since the widespread introduction of the Dvorak intensity-estimation method in the 1980s, only three tropical cyclones reached Category 5 intensity level-all in the Northwest Pacific basin. The Arctic continued to warm at about twice the rate compared with lower latitudes. Below-normal summer snowfall, a decreasing trend in surface albedo, and above-average surface and upper air temperatures resulted in a continued pattern of extreme surface melting, and net snow and ice loss on the Greenland ice sheet. Warmer-than-normal temperatures over the Eurasian Arctic in spring resulted in a new record-low June snow cover extent and spring snow cover duration in this region. In the Canadian Arctic, the mass loss from glaciers and ice caps was the greatest since GRACE measurements began in 2002, continuing a negative trend that began in 1987. New record high temperatures occurred at 20 m below the land surface at all permafrost observatories on the North Slope of Alaska, where measurements began in the late 1970s. Arctic sea ice extent in September 2011 was the second-lowest on record, while the extent of old ice (four and five years) reached a new record minimum that was just 19% of normal. On the opposite pole, austral winter and spring temperatures were more than 3 degrees C above normal over much of the Antarctic continent. However, winter temperatures were below normal in the northern Antarctic Peninsula, which continued the downward trend there during the last 15 years. In summer, an all-time record high temperature of -12.3 degrees C was set at the South Pole station on 25 December, exceeding the previous record by more than a full degree. Antarctic sea ice extent anomalies increased steadily through much of the year, from briefly setting a record low in April, to well above average in December. The latter trend reflects the dispersive effects of low pressure on sea ice and the generally cool conditions around the Antarctic perimeter.

Published
2012
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14. Genotype-phenotype study of familial haemophagocytic lymphohistiocytosis type 3

Author

Sieni, E., primary, Cetica, V., additional, Santoro, A., additional, Beutel, K., additional, Mastrodicasa, E., additional, Meeths, M., additional, Ciambotti, B., additional, Brugnolo, F., additional, zur Stadt, U., additional, Pende, D., additional, Moretta, L., additional, Griffiths, G. M., additional, Henter, J.-I., additional, Janka, G., additional, and Arico, M., additional

Published
2011
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19. Change in mean temperature as a predictor of extreme temperature change in the Asia-Pacific region

Author

Griffiths, G. M., primary, Chambers, L. E., additional, Haylock, M. R., additional, Manton, M. J., additional, Nicholls, N., additional, Baek, H.-J., additional, Choi, Y., additional, Della-Marta, P. M., additional, Gosai, A., additional, Iga, N., additional, Lata, R., additional, Laurent, V., additional, Maitrepierre, L., additional, Nakamigawa, H., additional, Ouprasitwong, N., additional, Solofa, D., additional, Tahani, L., additional, Thuy, D. T., additional, Tibig, L., additional, Trewin, B., additional, Vediapan, K., additional, and Zhai, P., additional

Published
2005
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24. Novel Munci 13-4 mutations in children and young adult patients with haemophagocytic lymphohistiocytosis.

Author

Santoro, A, Cannella, S, Bossi, G, Gallo, F, Trizzino, A, Pende, D, Dieli, F, Bruno, G, Stinchcombe, J C, Micalizzi, C, De Fusco, C, Danesino, C, Moretta, I, Notarangelo, I D, Griffiths, G M, and Aricò, M

Subjects
GENETIC mutation, CELL-mediated cytotoxicity, CELL transplantation, GENETIC markers, YOUNG adults, CHILDREN
Abstract

Familial haemophagocytic lymphohistiocytosis (FHL) is a genetically heterogeneous disorder characterised by constitutive defects in cellular cytotoxicity resulting in fever, hepatosplenomegaly and cytopenia, and the outcome is fatal unless treated by chemoimmunotherapy followed by haematopoietic stem-cell transplantation. Since 1999, mutations in the perform gene giving rise to this disease have been identified; however, these account only for 40% of cases. Lack of a genetic marker hampers the diagnosis, suitability for transplantation, selection of familial donors, identification of carriers, genetic counselling and prenatal diagnosis. Mutations in the Munc13-4 gene have recently been described in patients with FHL. We sequenced the Munc13-4 gene in all patients with haemophagocytic lymphohistiocytosis not due to PRF1 mutations. In 15 of the 30 families studied, 12 novel and 4 known Munc13-4 mutations were found, spread throughout the gene. Among novel mutations, 2650C→T introduced a stop codon; 441 del A, 532del C, 3082del C and 3226ins G caused a frameshift, and seven were mis sense mutations. Median age of diagnosis was 4 months, but six patients developed the disease after 5 years of age and one as a young adult of 18 years. Involvement of central nervous system was present in 9 of 15 patients, activity of natural killer cells was markedly reduced or absent in 13 of 1 3 tested patients. Chemo-immunotherapy was effective in all patients. Munc13-4 mutations were found in 15 of 30 patients with FHL without PRF1 mutations. Because these patients may develop the disease during adolescence or even later, haematologists should include FHL2 and FHL3 in the differential diagnosis of young adults with fever, cytopenia, splenomegaly and hypercytokinaemia. [ABSTRACT FROM AUTHOR]

Published
2006
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30. Excited levels and isobaric analogue states in57Co

Author

El-Kateb, Salah and Griffiths, G. M.

Abstract

The yield curve of the reaction56Fe(p,?)57Co has been measured over the energy rangeEp=1,300–1,900 keV and the decay of nine resonances has been investigated. For twelve of the resonances the strengths have been determined. The angular distributions of the gamma rays have been recorded for resonances atEp=1,599, 1,623, 1,643 and 1,649 keV, giving spin-parity assignmentsJp=3/2- for all four resonances. The resonances atEp=1,623, 1,643 and 1,649 keV have been identified as the split analogue resonances of the 367 (Jp=3/2-) states in57Fe. TheM1 transition strengths to the corresponding antianalogue states have been measured and compared with theoretical predictions.

Published
1981
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31. Molecular events during maturation of the immune response to oxazolone

Author

Berek, C., Griffiths, G. M., and Milstein, C.

Abstract

Sequence analysis of the heavy- and light-chain messenger RNA of hybridomas immunized with a specific hapten yields important clues about the interplay between genetic and selective events during the onset and maturation of the immune response. The maturation of the primary response to the hapten 2-phenyl-5-oxazolone is characterized by a drift to higher-affinity somatic variants of a germline-encoded basic sequence, whereas hybridomas from the secondary response demonstrate a further maturation dominated by a shift to alternative germline combinations.

Published
1985
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32. AN ISOSPIN 3/2 LEVEL OF BE9

Author

CALIFORNIA INST OF TECH PASADENA, Lynch,B., Griffiths,G. M., Lauritsen,T., CALIFORNIA INST OF TECH PASADENA, Lynch,B., Griffiths,G. M., and Lauritsen,T.

Abstract

A state of Be9 has been found at an excitation energy of 14.392=0.005 MeV, with a width less than 5 keV. The state is formed in the reaction Li7(He3, p)Be9 and corresponds closely in energy to the expected analogue of the ground state of Li9. These facts, together with the small width, suggest an assignment of T = 3/2. The angular distribution of protons corresponding to the 14.39 MeV state is nearly symmetric about 90 degrees in the centre-of-mass with maxima at 40 degrees and 150 degrees. The 90 degree differential cross sections are approximately the same for 6.5 and 10 MeV He3, with a minimum value between these energies. The total cross sections for 10 MeV He3 and 7.5 MeV are given. (Author), Pub. in Nuclear Physics v65 p641-6 1965 (Copies available only to DDC users).

Published
1964

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