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1. Caractéristiques des substrats et interactions dans les filières de co-digestion : cas particulier des co-substrats d’origine agro-industrielle

Author

GIRAULT, Romain ; LENDORMI, Thomas ; GUILLAUME, Sébastien ; PEU, Pascal ; BÉLINE Fabrice

Subjects
METHANISATION, BIOGAZ, CO-DIGESTION, FILIERE, SUBSTRATS, AGRICULTURE, INDUSTRIES, Environmental technology. Sanitary engineering, TD1-1066, Environmental sciences, GE1-350
Abstract

Pour assurer l’équilibre économique des unités de méthanisation, l’ajout de co-substrats est en général nécessaire. Pour les choisir, deux questions se posent aux porteurs de projets : quelles sont les caractéristiques des co-substrats disponibles et quel est l’impact des mélanges sur le fonctionnement du digesteur. Le présent article se propose de répondre à ces questions sur la base des résultats du projet Biodecol2.

Published
2013

2. Focus – La co-digestion anaérobie des boues d’épuration et de déchets organiques d’origine périurbaine

Author

BÉLINE, Fabrice, GIRAULT, Romain, and BRIDOUX, Gilbert

Subjects
METHANISATION, BIOGAZ, CO-DIGESTION, BOUES D'EPURATION, DECHETS ORGANIQUES, STEP, Environmental technology. Sanitary engineering, TD1-1066, Environmental sciences, GE1-350
Abstract

En France, et ce principalement pour des raisons économiques, la méthanisation des boues d’épuration est encore peu appliquée dans les stations de petite et moyenne capacité. Pour améliorer le bilan économique de la digestion anaérobie des boues d’épuration dans ce type de station, il est possible de compléter les alimentations du digesteur par d’autres substrats organiques à plus fort potentiel énergétique et déjà présents sur le territoire. Quels sont les impacts de tels procédés et comment optimiser leur intégration dans la filière de traitement des eaux ?

Published
2013

3. Enjeux et perspectives pour le développement de la méthanisation agricole en France

Author

BÉLINE, F., GIRAULT, Romain, PEU, Pascal, TREMIER, Anne, and TEGLIA, Cécile

Subjects
Méthanisation, Agriculture, Environnement, Énergie, France, Environmental technology. Sanitary engineering, TD1-1066, Environmental sciences, GE1-350
Abstract

Face à l'épuisement programmé de la ressource énergétique fossile et au réchauffement climatique, les énergies renouvelables suscitent un intérêt croissant. Parmi ces énergies renouvelables, le biogaz issu de la méthanisation agricole présente de nombreux intérêts environnementaux, économiques et sociaux.

Published
2012

5. Energy cover crops for biogas production increase soil organic carbon stocks: A modeling approach

Author

Florent Levavasseur, Patrice K. Kouakou, Julie Constantin, Romain Cresson, Fabien Ferchaud, Romain Girault, Vincent Jean‐Baptiste, Hélène Lagrange, Sylvain Marsac, Sylvain Pellerin, and Sabine Houot

Subjects
AMG, anaerobic digestion, arable crops, biogas, cover crop, France, Renewable energy sources, TJ807-830, Energy industries. Energy policy. Fuel trade, HD9502-9502.5
Abstract

Abstract Energy cover crops for biogas production through anaerobic digestion (AD) are inserted between two primary crops. They replace either bare soil or nonharvested cover crops, and their management is usually intensified to produce more biomass. They allow the production of renewable energy as well as digestate, used as an organic fertilizer, without directly competing with food production. Because of the increased biomass production and export and of the return of a digested biomass to the soil, the impact of energy cover crops on soil organic carbon (SOC) is questioned. The objective of this paper was to study the difference in SOC stocks induced by the introduction of energy cover crops for AD coupled with the application of the resulting amount of digestate. We used the AD model Sys‐Metha combined with the soil C model AMG to simulate SOC stocks for 13 case studies in France, with scenarios comparing different intercrop management practices, with or without cover crops, harvested or not. Our results indicated that the higher biomass production of energy cover crops (from 6.7 to 11.1 t DM ha−1) in comparison with nonharvested cover crops (2 t DM ha−1) or bare soil led to higher humified C input (belowground input and digestate), despite the high C fraction exported in AD. This resulted in an increase in SOC stocks in comparison with nonharvested cover crops or bare soil (from 0.01 to 0.12 t C ha−1 year−1 over 30 years). The uncertainties in the model parameters did not modify these results. However, in the case of equal biomass production between energy cover crops and nonharvested cover crops, SOC stocks would be lower with energy cover crops.

Published
2023
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10. Physico-chemical, biochemical and nutritional characterisation of 42 organic wastes and residues from France

Author

Henry Fisgativa, Cyril Marcilhac, Romain Girault, Marie-Line Daumer, Anne Trémier, Patrick Dabert, and Fabrice Béline

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Science (General), Q1-390
Abstract

The data presented in this article regroup characterisation of organic matter and nutritional composition of 42 organic wastes and residues usually used as substrates for anaerobic digestion. Those wastes have different origins from agro-industrial, agricultural and urban sectors in France including: algae, slaughterhouse waste, fat, food waste, fruits and vegetables residues, green waste, slurry, manure, wastewater treatment plant sludge and agricultural residues. The properties of organic matter are distinguished between global parameters (pH, total solids, volatile solids, COD and BMP), organic matter fractionation (biochemical and Van Soest) and the main nutrients content (N, P, K, Mg, Ca and S).

Published
2018
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12. Energy cover crops for biogas production increase soil organic carbon stocks: A modeling approach

Author

Levavasseur, Florent, Kouakou, Patrice Koffi, Constantin, Julie, Cresson, Romain, Ferchaud, Fabien, Girault, Romain, Jean-Baptiste, Vincent, Lagrange, Hélène, Marsac, Sylvain, Pellerin, Sylvain, Houot, Sabine, Levavasseur, Florent, Kouakou, Patrice Koffi, Constantin, Julie, Cresson, Romain, Ferchaud, Fabien, Girault, Romain, Jean-Baptiste, Vincent, Lagrange, Hélène, Marsac, Sylvain, Pellerin, Sylvain, and Houot, Sabine

Abstract

Energy cover crops for biogas production through anaerobic digestion (AD) are inserted between two primary crops. They replace either bare soil or nonharvested cover crops, and their management is usually intensified to produce more biomass. They allow the production of renewable energy as well as digestate, used as an organic fertilizer, without directly competing with food production. Because of the increased biomass production and export and of the return of a digested biomass to the soil, the impact of energy cover crops on soil organic carbon (SOC) is questioned. The objective of this paper was to study the difference in SOC stocks induced by the introduction of energy cover crops for AD coupled with the application of the resulting amount of digestate. We used the AD model Sys-Metha combined with the soil C model AMG to simulate SOC stocks for 13 case studies in France, with scenarios comparing different intercrop management practices, with or without cover crops, harvested or not. Our results indicated that the higher biomass production of energy cover crops (from 6.7 to 11.1 t DM ha−1) in comparison with nonharvested cover crops (2 t DM ha−1) or bare soil led to higher humified C input (belowground input and digestate), despite the high C fraction exported in AD. This resulted in an increase in SOC stocks in comparison with nonharvested cover crops or bare soil (from 0.01 to 0.12 t C ha−1 year−1 over 30 years). The uncertainties in the model parameters did not modify these results. However, in the case of equal biomass production between energy cover crops and nonharvested cover crops, SOC stocks would be lower with energy cover crops.

Published
2023

17. Incorporating energy cover crops for biogas production into agricultural systems: benefits and environmental impacts. A review

Author

Camille Launay, Sabine Houot, Sylvain Frédéric, Romain Girault, Florent Levavasseur, Sylvain Marsac, and Julie Constantin

Subjects
Environmental Engineering, Agronomy and Crop Science
Abstract

Some European countries are exploring the idea of replacing dedicated crops with energy cover crops for biogas production. Indeed, energy cover crops can generate consequential biomass without competing with food crops for land use. However, the potential benefits and impacts of this choice are not fully understood. Here, we review what is known about the consequences of energy cover crop usage by examining management regimes and digestate use, including impacts on the environment and cropping system performance. First, compared to cover crops, energy cover crops are intensively managed to produce more biomass (< 5 t DM/ha vs. up to 16 t DM/ha). Second, nitrogen is conserved during anaerobic digestion and is more readily available to crops in digestate than in cover crops residues. However, ammonia is lost via volatilization, which could reduce nitrogen use efficiency, depending on the storage conditions and application method. Third, 43–80% of the crops’ initial carbon is transformed into biogas. That said, levels of soil carbon storage may nonetheless resemble those obtained with cover crops left behind because carbon is stabilized during anaerobic digestion and the energy cover crops’ roots and stubble are left behind in the soil. Fourth, energy cover crops can act as multiservice cover crops, reducing nitrate leaching, improving soil microbial activity, and enhancing soil physical properties during the fallow period. Fifth, energy cover crop usage can have certain disservices, such as soil compaction, the need for additional inputs (e.g., irrigation, fertilization, pesticides), reduced groundwater recharge, and reduced following crop yield. In summary, expanding the usage of energy cover crops for biogas production does not seem to be an environmental threat. However, care must be taken to avoid the intensification of irrigation and lengthening growing periods to boost biomass, which could reduce food production.

Published
2022
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18. Analyse spatialisée pour l'aide à la planification des projets de méthanisation collective

Author

BIOTEAU, Thierry ; TRETYAKOV, Oleksander ; BORET, Florian ; BÉLINE, Fabrice ; BALYNSKA, Maryna ; LAURENT, Faustine ; GIRAULT, Romain

Subjects
METHANISATION, AGRICULTURE, SIG, ANALYSE SPATIALISEE, BIOGAZ, TERRITOIRES, Environmental technology. Sanitary engineering, TD1-1066, Environmental sciences, GE1-350
Abstract

Le développement de la méthanisation dépend de plusieurs facteurs. Il s’agit, entre autres, des ressources disponibles, de leur proximité, des caractéristiques de l’économie locale et de leur impact sur le processus de décision. Ces éléments doivent nécessairement être pris en compte pour une mise en place pertinente de centres de production de biogaz. L’analyse menée en Pays de Fougères envisage tous ces points et permet de dégager différents scenarii.

Published
2013

22. Integrated assessment of agricultural biogas plants and their long term performances

Author

Colas, Floriane, Bareha, Younès, Girault, Romain, Soulié, Jean-Chritophe, Belorgey, Marine, Misslin, Renaud, Therond, Olivier, and Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
agricultural biogas, [SDV.EE.ECO]Life Sciences [q-bio]/Ecology, environment/Ecosystems, biomass, [SDV.SA.AGRO]Life Sciences [q-bio]/Agricultural sciences/Agronomy, integrated assessment, cropping system, fertilizer, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation
Abstract

International audience; To reach the objective of carbon neutrality, farming systems have to continue improving their GHG balance. Agricultural biogas plants can potentially help reduce mineral fertilizer dependance and provide renewable energy to be used in susbtitution to fossil ones, by producing a nutrient rich digestate and biogas. Biogas plant can also offer economic values for some biomass like the ones produced by cover crops while digested. In contrast, soil fertility losses and biomass transport are potential problems associated with developement of biogas plants. Trade-offs between these positive and negative impacts depend cropping and farming systems and plant management. Identifying sustainable configuration and management of the complex multi-level farms-biogas systems remains a scientific and societal issue. This work aims at presenting an integrated assessment and modelling of farms-biogaz systems. It is based on the use of MAELIA, a multi-agent platform for integrated assessment and modeling of territorial bioeconomy systems and SYS-Metha, a mass balance model which predicts carbon and nitrogen fluxes in anaerobic digestion systems. This plateform simulates intra and inter-annual dynamics of cropping systems, associated with biogeochemical cycles, agricultural biomass flows and biogas plant flows (biogas, digestate). As a result it estimates indicators reagarding the biogas production (biogas and electricity), farm production (yield, gross margin), nitrogen and carbon cycles as well as greenhouse gas originating from the whole complex farms-biogas plant. In this study, we evaluated several complex farms-biogas plant, from a small plant managed by 4 farmers to a biger one feeded by 18 farmers and managed by their farming cooperative. We evaluated their cropping systems before and after the biogas plant establishment and the long term performances of farms-biogaz system.

Published
2021

23. Concept-Dig, outil d’aide à la conception de filière pour la valorisation agronomique des digestats

Author

Jimenez, Julie, Girault, Romain, Tremier, Anne, Wallrich, Anne, Calmettes, Claire, Christ, Florian, Ollivier, Denis, Patureau, Dominique, Latrille, Eric, Commandre, Jean-Michel, Houot, Sabine, Laboratoire de Biotechnologie de l'Environnement [Narbonne] (LBE), Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Gestion environnementale et traitement biologique des déchets (UR GERE), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Ecologie fonctionnelle et écotoxicologie des agroécosystèmes (ECOSYS), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Methachrist, Trame [Paris], Institut National de la Recherche Agronomique (INRA)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), and AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
[SDE]Environmental Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020

24. New crop fertilization strategies after introduction of anaerobic digesters in a territory and their consequences on carbon and nitrogen dynamics in soils: case study of the Versailles plain

Author

Launay, Camille, Crépeau, Marianne, Girault, Romain, Levavasseur, Florent, Houot, Sabine, AGroécologie, Innovations, teRritoires (AGIR), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Ecologie fonctionnelle et écotoxicologie des agroécosystèmes (ECOSYS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Optimisation des procédés en Agriculture, Agroalimentaire et Environnement (UR OPAALE), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Launay, Camille

Subjects
[SDV.SA.AGRO] Life Sciences [q-bio]/Agricultural sciences/Agronomy, [SDE.IE]Environmental Sciences/Environmental Engineering, [SDV.SA.AGRO]Life Sciences [q-bio]/Agricultural sciences/Agronomy, [SDE.IE] Environmental Sciences/Environmental Engineering, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020

26. Projet MéthaPolSol, impacts de l'introduction de méthaniseurs dans un territoire sur les stratégies de fertilisation des cultures et leurs conséquences sur les dynamiques du carbone et de l'azote dans les sols : cas de la plaine de Versailles

Author

Launay, Camille, Crépeau, Marianne, Girault, Romain, Levavasseur, Florent, Houot, Sabine, Launay, Camille, AGroécologie, Innovations, teRritoires (AGIR), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Ecologie fonctionnelle et écotoxicologie des agroécosystèmes (ECOSYS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Optimisation des procédés en Agriculture, Agroalimentaire et Environnement (UR OPAALE), and Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
[SDV.SA.AGRO] Life Sciences [q-bio]/Agricultural sciences/Agronomy, [SDE.IE]Environmental Sciences/Environmental Engineering, [SDV.SA.AGRO]Life Sciences [q-bio]/Agricultural sciences/Agronomy, [SDE.IE] Environmental Sciences/Environmental Engineering, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020

27. Modelling the dynamic long-term performance of a full-scale digester treating sludge from an urban WRRF using an extended version of ADM1

Author

Guillermo Baquerizo, Sylvie Gillot, Justine Fiat, Romain Girault, Pierre Buffière, Universidad Iberoamericana Puebla, Partenaires INRAE, Réduire, valoriser, réutiliser les ressources des eaux résiduaires (UR REVERSAAL), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Déchets Eaux Environnement Pollutions (DEEP), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA), and Optimisation des procédés en Agriculture, Agroalimentaire et Environnement (UR OPAALE)

Subjects
General Chemical Engineering, Full scale, 02 engineering and technology, Fractionation, 010402 general chemistry, 01 natural sciences, Industrial and Manufacturing Engineering, Methane, chemistry.chemical_compound, [CHIM.GENI]Chemical Sciences/Chemical engineering, Environmental Chemistry, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, Process engineering, ComputingMilieux_MISCELLANEOUS, Resource recovery, [SDE.IE]Environmental Sciences/Environmental Engineering, business.industry, General Chemistry, Biodegradation, 021001 nanoscience & nanotechnology, 6. Clean water, 0104 chemical sciences, Anaerobic digestion, Activated sludge, chemistry, Digestate, Environmental science, 0210 nano-technology, business
Abstract

The optimization of full-scale digesters requires the development of models able to describe the main process performances, due to the strategic role of anaerobic digestion in the sustainability of Water Resource Recovery Facilities (WRRF). In this study, an extended version of the Anaerobic Digestion Model No 1 (ADM1) was developed to simulate the long-term performances of a full-scale anaerobic digester treating primary and activated sludge of a large WWRF (300 000 pe). Monitored data were collected over 973 days and analyzed in order to provide reconciled datasets for modeling purposes. A comprehensive influent characterization in terms of biodegradability extent, COD and N content was carried out by combining measurements of several parameters and Biochemical Methane Potential (BMP) tests to provide an ADM1 compatible substrate fractionation. The model was calibrated by comparing simulation results against both routinely measurements and data from a dedicated measuring campaign. Disintegration coefficients and particulate inert fractions were the sole estimated model parameters. Disintegration coefficients determined in the calibration step resulted in values 5-times greater than those initially estimated from BMP tests. The model was able to accurately predict digestate composition in terms of TSS, VSS, COD, N and P content as well as methane content and biogas production rate. It was demonstrated that a precise description of the anaerobic co-digestion of sewage sludges relies on the estimation of solubilization kinetic parameters together with the use of two different composite variables representing each substrate. The developed model proved to be a useful tool that can be integrated in a plant-wide model to assess plant process interactions under different operating conditions.

Published
2021
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29. Effect of Operating Parameters on the Dewatering Performance of Press Filters: A Sensitivity Analysis

Author

Julian Tosoni, Jean-Christophe Baudez, Romain Girault, Technologies et systèmes d'information pour les agrosystèmes (UR TSCF), and Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)

Subjects
Engineering, business.industry, General Chemical Engineering, Process (computing), Environmental engineering, POLYMER, Residual, Dewatering, law.invention, Activated sludge, Filter (video), law, [SDE]Environmental Sciences, Sensitivity (control systems), Physical and Theoretical Chemistry, Process engineering, business, Filtration, FILTRE PRESSE
Abstract

International audience; To optimize the press filters commonly used to dewater residual sludge, the impact of the operating parameters must be better understood. The objectives of this article are (1) to identify the impact of the operating parameters on press filter performances and (2) to classify the operating parameters regarding their impact on dewatering performances. Experiments were performed with conditioned activated sludge in a tangential filtration cell, and a sensitivity analysis of the process was performed. This study emphasizes that cake thickness and filtration pressure have the most significant impacts on dewatering efficiency. These results suggest a promising outlook for press-filter optimization

Published
2015
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30. In quest of environmental hotspots of sewage sludge treatment combining anaerobic digestion and mechanical dewatering: A life cycle assessment approach

Author

Marilys Pradel, Romain Girault, Sarah Berthault, Julian Tosoni, Marion Richard, Claire Gourdet, Optimisation des procédés en Agriculture, Agroalimentaire et Environnement (UR OPAALE), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Institut Pascal (IP), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-SIGMA Clermont (SIGMA Clermont)-Centre National de la Recherche Scientifique (CNRS), Technologies et systèmes d'information pour les agrosystèmes (UR TSCF), EcoSD Network, TSCF, Hôpital Jean Minjoz, Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon), and Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Sigma CLERMONT (Sigma CLERMONT)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Strategy and Management, 0208 environmental biotechnology, 02 engineering and technology, 010501 environmental sciences, 01 natural sciences, 7. Clean energy, Industrial and Manufacturing Engineering, 12. Responsible consumption, Biogas, Life-cycle assessment, Nitrogen cycle, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences, General Environmental Science, Waste management, Renewable Energy, Sustainability and the Environment, Dewatering, 6. Clean water, 020801 environmental engineering, Anaerobic digestion, 13. Climate action, [SDE]Environmental Sciences, Sewage sludge treatment, Environmental science, Eutrophication, Sludge
Abstract

[Departement_IRSTEA]Ecotechnologies [TR1_IRSTEA]INSPIRE [TR2_IRSTEA]TED; International audience; Life cycle assessment was used to assess environmental impacts and a sensitivity analysis of 17 key technological parameters to identify the main environmental hotspots associated with the performance of a sewage sludge treatment. The scenario takes into account primary and secondary sludge and includes gravity and centrifugal thickening, anaerobic digestion with cogeneration of heat and electricity from biogas, mechanical dewatering and spreading on agricultural fields. All the relevant inputs (electricity, heat, reagents, infrastructure, fuel, transport) and outputs (emissions to air, water and soil) are accounted for in the assessment, including the sludge return liquors from thickening and dewatering processes. This study focuses on climate change, terrestrial acidification, freshwater eutrophication, human toxicity and ionizing radiation impact categories assessed using the ReCiPe E v1.08/Europe baseline method. The results showed that the most sensitive parameters are the biodegradation rate of volatile solids and the nitrogen mineralization rate during anaerobic digestion, phosphorus and nitrogen capture rates during the thickening and dewatering processes, and the consumption of FeCl3 for the treatment of sludge before dewatering. The results suggest that the environmental performances of the sewage sludge treatment line could be enhanced by increasing the production of biogas (by increasing the biodegradation rate of volatile solids), by decreasing the consumption of FeCl3 used for sludge treatment, and by finding alternative treatments for sludge return liquors.

Published
2017
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32. Long-term dynamic simulation of a full-scale anaerobic digester treating sludge from an urban WWTP: model calibration and validation

Author

Baquerizo, G., Justine, Fiat, Buffière, Pierre, Girault, Romain, Gillot, Sylvie, Milieux aquatiques, écologie et pollutions (UR MALY), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Déchets Eaux Environnement Pollutions (DEEP), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon, and Buffière, Pierre

Subjects
[CHIM.GENI]Chemical Sciences/Chemical engineering, [SPI.GPROC] Engineering Sciences [physics]/Chemical and Process Engineering, [CHIM.GENI] Chemical Sciences/Chemical engineering, [SDE.IE]Environmental Sciences/Environmental Engineering, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, [SDE.IE] Environmental Sciences/Environmental Engineering, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2016

33. MODÉLISATION DYNAMIQUE D'UN DIGESTEUR DE BOUES D'ÉPURATION : CALAGE ET VALIDATION DU MODÈLE

Author

Baquerizo, G., Fiat, Justine, Buffière, Pierre, Girault, Romain, Gillot, Sylvie, Milieux aquatiques, écologie et pollutions (UR MALY), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Déchets Eaux Environnement Pollutions (DEEP), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA), Hydrosystèmes et bioprocédés (UR HBAN), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon, Hydrosystèmes et Bioprocédés (UR HBAN), and Buffière, Pierre

Subjects
[CHIM.GENI]Chemical Sciences/Chemical engineering, [SPI.GPROC] Engineering Sciences [physics]/Chemical and Process Engineering, [CHIM.GENI] Chemical Sciences/Chemical engineering, [SDE.IE]Environmental Sciences/Environmental Engineering, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, [SDE.IE] Environmental Sciences/Environmental Engineering, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2016

34. Sludge Dewatering: Influence of operating parameters on dryness limit determination

Author

Ginisty, Pascal, Girault, Romain, Tosoni, Julian, Dieudé-Fauvel, Emilie, OLIVIER, Jérémy, Vaxelaire, Jean, IFTS, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), LABORATOIRE DE THERMIQUE ENERGETIQUE ET PROCEDES (EA1932) (LATEP), and Université de Pau et des Pays de l'Adour (UPPA)

Subjects
flocculation, dryness limit, polymer, sludge dewatering, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, filtration-compression cell, drainage
Abstract

International audience; Dewatering process efficiency, classically assessed by a parameter "dryness limit", is strongly, affected by conditioned sludge properties and by operating conditions. The medthod to measure its parameters is based on a filtration-compression test, which depends significantly on operating conditions. A standard method is under progess in France to develop a better controlled procedure. This paper presents the impact of solids load, pressure and compression time, filter cloth, flocculation conditions, pre-thickening and storage time on the dryness limit for different kinds of sludge. A comparison with industrial devices was also made.

Published
2014

35. DRYNESS LIMIT: A USEFUL PARAMETER TO ASSESS SLUDGE DEWATERING

Author

Ginisty, Pascal, GUEI, Frédérique, Girault, Romain, Tosoni, Julian, OLIVIER, Jérémy, Vaxelaire, Jean, IFTS, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), LABORATOIRE DE THERMIQUE ENERGETIQUE ET PROCEDES (EA1932) (LATEP), and Université de Pau et des Pays de l'Adour (UPPA)

Subjects
Dryness limit, Sludge dewatering, Filtration-compression cell, Flocculation, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering
Abstract

International audience; It is usually recognized that sludge management is a major problem in water and wastewater treatment, as it can account for up to 50% of total operating costs. The effectiveness and cost of sludge treatment and disposal operations are strongly affected by its volume. Hence, the water content (or solids concentration) of the sludge is a key parameter which can impact the different steps of the whole treatment. Consequently, thickening and dewatering are key steps in the total sludge processing train. Sludge is classically dewatered by centrifuge, filter-press, belt filter or screw filters. In every case, the process efficiency is strongly affected by sludge properties. That is why users and suppliers need a parameter to assess sludge dewaterability and a standard method to measure it. Suppliers might use this standard data to guarantee dewatering performances of their equipment. The dryness limit is a well-known parameter used by French actors of sludge treatment. It is classically measured by a filtration-compression test until filtrate flowing stops. However, for highly compressible sludges, this condition is difficult to reach. That is why a simple mathematical model fitting compression data was used to extrapolate data for dryness limit assessment. The objective of the research is to study the role of every operating condition listed in FD-T 97001-1 relative to sludge dryness in order to recommend values for analysts. The influence of test time, pressure, cake thickness, filter cloth, flocculation conditions, pre-thickening and storage time on the dryness limit was strongly discussed for different kind of sludge.The results enable to establish a proper procedure to measure the dryness limit. This limit is always higher than the dryness reached with industrial devices. The deviation depends mainly on the sludge nature and the type of dewatering equipment used.

Published
2013

37. Influent fractionation and parameter calibration for ADM1: Lab-scale and full-scale experiments

Author

Girault, Romain, Steyer, Jean-Philippe, Zaher, Usama, Sadowski, A. G., Nopens, Ingmar, Béline, Fabrice, Zak, A., Kujawski, O., Holm, N.C., Rönner-Holm, S.G.E., Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF), Laboratoire de Biotechnologie de l'Environnement [Narbonne] (LBE), Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA), Department of Biological Systems Engineering, University of Wisconsin-Madison, Laboratoire Systèmes Hydrauliques Urbains, Ecole Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES), Université de Strasbourg (UNISTRA), BIOMATH, Ghent University [Belgium] (UGENT), Lublin University of Technology, Faculty of Environmental Protection Engineering, Czestochowa University of Technology, LimnoTec Abwasseranlagen Gmbh, Institut National de la Recherche Agronomique (INRA)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Laboratoire des Systèmes hydrauliques urbains, École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université Louis Pasteur - Strasbourg I, Universiteit Gent = Ghent University [Belgium] (UGENT), and Young Water Professionals committee (YWP). INT.

Subjects
anaerobic digestion, modelling, numerical models, calibration, adm1, fractionation, [SDV]Life Sciences [q-bio], digestion anaérobie, fractionnement, modèle
Abstract

This paper presents two methods for the characterisation of input and calibration of an ADM1 model. The first, which is adapted for predictive studies, is named “anaerobic respirometry” and consists of a fractionation obtained by the numerical interpretation of methane production rate curves. These curves are obtained in batch experiments after a pulse of studied substrate in an anaerobic sludge. The second method is developed for full-scale application and complex substrates. The fractionation is initially based on balancing previously measured nitrogen, NH4-N and COD contents in influent, reactor and effluent, and combined with the online gas curve calibration procedure for further fine tuning of input fractionation and detection of kinetic parameters for calibration.

Published
2010

39. Effect of weight-adjusted intermediate-dose versus fixed-dose prophylactic anticoagulation with low-molecular-weight heparin on venous thromboembolism among noncritically and critically ill patients with COVID-19: the COVI-DOSE trial, a multicenter, randomised, open-label, phase 4 trial

Author

Zuily, Stéphane, Lefèvre, Benjamin, Sanchez, Olivier, Empis de Vendin, Ombeline, de Ciancio, Guillaume, Arlet, Jean-Benoît, Khider, Lina, Terriat, Béatrice, Greigert, Hélène, Robert, Céline, Louis, Guillaume, Trinh-Duc, Albert, Rispal, Patrick, Accassat, Sandrine, Thiery, Guillaume, Montani, David, Azarian, Réza, Meneveau, Nicolas, Soudet, Simon, Le Mao, Raphaël, Maurier, François, Le Moing, Vincent, Quéré, Isabelle, Yelnik, Cécile, Lefebvre, Nicolas, Martinot, Martin, Delrue, Maxime, Benhamou, Ygal, Parent, Florence, Roy, Pierre-Marie, Presles, Emilie, Goehringer, François, Mismetti, Patrick, Bertoletti, Laurent, Rossignol, Patrick, Couturaud, Francis, Wahl, Denis, Thilly, Nathalie, Laporte, Silvy, Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), F-Crin Innovte [CHU Saint-Etienne], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Adaptation, mesure et évaluation en santé. Approches interdisciplinaires (APEMAC), Université de Lorraine (UL), Innovations thérapeutiques en hémostase = Innovative Therapies in Haemostasis (IThEM - U1140), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Service de Cardiologie [CHRU Nancy], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), CHR de Metz-Thionville, Centre Hospitalier Agen-Nérac, Hôpital Bicêtre, Université Paris-Saclay, Centre Hospitalier de Versailles André Mignot (CHV), Department of Cardiology, University Hospital Jean Minjoz, Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC), CHU Amiens-Picardie, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), UNEOS, Département Maladies Infectieuses et Tropicales, Hôpital Universitaire, Montpellier, France, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Hôpital Lapeyronie [Montpellier] (CHU), Institut Desbrest de santé publique (IDESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Université de Lille, CHU Lille, Centre National de Référence des Maladies Auto-Immunes Systémiques Rares du Nord et Nord-Ouest de France (CeRAINO), Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Les Hôpitaux Universitaires de Strasbourg (HUS), Hôpitaux Civils de Colmar, Service d’Hématologie Biologique [CHU Lariboisière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Endothélium, valvulopathies et insuffisance cardiaque (EnVI), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université d'Angers (UA), CHU d'Angers [Département Urgences], Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Université Jean Monnet - Saint-Étienne (UJM), Santé Ingénierie Biologie Saint-Etienne (SAINBIOSE), Centre Ingénierie et Santé (CIS-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service des Maladies Infectieuses et Tropicales [CHRU Nancy], Service de Chirurgie Vasculaire [CHU Saint-Etienne], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM), Centre d'Investigation Clinique - Epidémiologie Clinique Saint-Etienne (CIC-EC), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], Centre Hospitalier Princesse Grace, Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), French Ministry of Health, CAPNET, Grand-Est Region, Grand-Nancy Métropole., and COVI-DOSE investigators: Stéphane Zuily, Francis Couturaud, François Goehringer, Silvy Laporte, Patrick Mismetti, Emilie Presles, Patrick Rossignol, Nathalie Thilly, Denis Wahl, Thomas Lecompte, Emmanuel Oger, Marie-Antoinette Sevestre, Florence Parent, Ygal Benhamou, Pierre-Marie Roy, Tristan Gigante, Morgane Gilg, Pierre-Luc Maclot, Bénédicte Rossignol, Jonathan Udot, Hélène Bouteille, Andréa Buchmuller, Céline Peurière, El Mehdi Siaghy, Valérie Bouaziz, Charlotte Daguin, Benjamin Grosjean, Véronique Saunier, Laurence Verger, Madlyne Jacquot, Nadine Petitpain, Martin Charly, Laurent Tordella, Emilie Presles, Guillaume Baronnet, Elisabeth Baux, Athanase Benetos, Jean-Baptiste Blanvillain, Marie Conrad, Guilhem Courte, Aurélie Cravoisy-Popovic, Virginie Dufrost, Sébastien Gibot, Philippe Guerci, Laure Joly, Antoine Kimmoun, Matthieu Koszutski, Alexandrine Larue, Bruno Levy, Marie-Reine Losser, Mathieu Mattei, Lionel Nace, Emmanuel Novy, Pierre Perez, Jean-Pierre Pertek, Camille Rigaux, Alexis Sauvage, Evelyne Schvoerer, Carine Thivilier, Lev Volkov, Piotr Zieminski, Manil Benlounes, Charles Cheng, Jean-Baptiste de Fréminville, Grégoire Détriché, Emmanuel Flammarion, Guillaume Goudot, Amer Hamdan, Raphaël Hindré, Corina Manoli, Emmanuel Messas, Adrien Michon, Tristan Mirault, Jean Pastré, Marie-Aude Penet, Benjamin Planquette, Geoffroy Volle, Rémy Hamdan, Aline Laubriet-Jazayeri, Vincent Petit, Lionel Piroth, Jean Pierre Quenot, Mélissa Saccu, Damien Barraud, Zoé Cavalli, Rostane Gaci, Mathilde Andreu, Laurent Bertoletti, Andréa Buchmuller, Elodie De Magalhaes, Sophie Bulifon, Athénaïs Boucly, Nathan Ebstein, Marc Humbert, Xavier Jaïs, Mitja Jevnikar, Laurent Savale, Andrei Horia Seferian, Charlotte Colin, Timothée Ganem, Mehdi Roumila, Romain Chopard, Matthieu Besutti, Basile Mouhat, Claire Andrejak, Stéphane Dupas, Gaëlle Le Roy, Santhi Samy-Modeliar, Anne Coste, Alexandre Fauche, David Goetghebeur, Christophe Gut-Gobert, Clément Hoffmann, Baptiste Hourmant, Cécile L'hévéder, Emmanuelle Lemoigne, Olivier Nepveu, Raphaël Paret, Gaël Picart, Saïd Azerkan, Chadia Boudaa, Julien Campagne, Peter Eszto, Benoît Godbert, Jean-François Guichard, Marion Heschung, Antoine Legoff, Jacques Mariot, Pascale Martin, Magalie Mercy, Julie Perrin, Stéphane Raymond, Nathalie Vernier, Pierre Fesler, Pierrick Henneton, Cédric Mercuzot, Nathalie Pansu, Lucas Perez, Loïc Andre, Edgar Bakhache, Marie-Charlotte Chopin, Marie Gilbert, Marc Lambert, Mohammad Ryadh Pokeerbux, François Danion, Yves Hansmann, Estelle Rougier, Yvon Ruch, Dominique Stéphan, Axel Ursenbach, Isabelle Connerade, Simon Gravier, Damien Kayser, Jean-Marc Michel, Mahsa Mohseni, Waël Younes, Ruxandra Burlacu, Amanda Lopes, Stéphane Mouly, Kladoum Nassarmadji, Damien Sène, Virginie Siguret, Alain Stepanian, Cédric Annweiler, Antoine Brangier, Vincent Dubee, Samir Henni, Jeanne Hersant, Jocelyne Loison, Léa Kern, Jean-Baptiste Laine, Claire Neveux-Brecheteau, Lucia Perez, Ruben Benainous, Bénédicte Giroux-Leprieur, Marilucy Lopez-Sublet, Saïda Khaled-Jousselin, Yohann Bernard, Amélie Amiot, Jessica Breistroff, Emilie Detry, Kadidiatou Diallo, Agnès Didier, Nathalie Dumont, Julie Egensperger, Aurélie Emmerich, Nelly François, Fanny Gallo, Valérie George, Quentin Gérome, Aurélie Gutehrle, Laure Lehman, Séverine Petit, Vanessa Piard, Maximilien Saint-Gilles, Olivier Terenzi, Amélie Marquette, Hélène Mortelette, Mathilde Audry, Amélie Cransac, Marine Maillard, Anaïs Boyer, Floriana Gallo, Arielle Urbing, Imane Zahaf, Alexandra Byczko, Amina Chaalal, Georgette Berlier, Corinne Bernabe, Souad Bezzeghoud, Caroline Chaudier, Carole Chauvet, Marina Davier, Carine Labruyere, Estelle Perrin, Michaël Pierre, Claire-Annissa Chekirine, Florence Voivret, Ramdane Meftali, Ouaffa Sabri, Anaïs Beulaygue, Julie Gall, Laure Girard, Soumia Haddaoui, Scheherazade Rami, Auriane Couderc, Aude Le Breton, Marie-Line Perruche, Cindy Claudon, Ludivine Roussel, Aude Barnier, Tiphaine Blanchard, Bénédicte Le Gall, Mélanie Pelouin, Anne-Sophie Veillon, Quam Aquereburu, Charlène Delaygue, Zahoua Ait Idir, Jérémy Drugeon, Déborah Dubrulle, Rabah Tezkratt, Anne-Sophie Frantz, Julie Drouaine, Jacqueline Dubois, Magali Eyriey, Elina Haerrel, Mélinda Beaudenon, Mialy Guenet, Thibaud Lecerf, Stéphanie Marechal-Girault, Sami Rehaiem, Romain Simon, Florence Dangeul-Potier, Morgane Goulvent, Souha Fliss, Fadhila Messani, Béatrice Mizejewski, Brigitte Mugnier, Valérie Opderbeck, Brigitte Risse

Subjects
Anticoagulation, Heparin, [SDV]Life Sciences [q-bio], COVID-19, Venous thromboembolism
Abstract

International audience; Background: Venous thromboembolism is a major complication of coronavirus disease 2019 (COVID-19). We hypothesized that a weight-adjusted intermediate dose of anticoagulation may decrease the risk of venous thromboembolism COVID-19 patients.Methods: In this multicenter, randomised, open-label, phase 4, superiority trial with blinded adjudication of outcomes, we randomly assigned adult patients hospitalised in 20 French centers and presenting with acute respiratory SARS-CoV-2. Eligible patients were randomly assigned (1:1 ratio) to receive an intermediate weight-adjusted prophylactic dose or a fixed-dose of subcutaneous low-molecular-weight heparin during the hospital stay. The primary outcome corresponded to symptomatic deep-vein thrombosis (fatal) pulmonary embolism during hospitalization (COVI-DOSE ClinicalTrials.gov number: NCT04373707).Findings: Between May 2020, and April 2021, 1000 patients underwent randomisation in medical wards (noncritically ill) (80.1%) and intensive care units (critically ill) (19.9%); 502 patients were assigned to receive a weight-adjusted intermediate dose, and 498 received fixed-dose thromboprophylaxis. Symptomatic venous thromboembolism occurred in 6 of 502 patients (1.2%) in the weight-adjusted dose group and in 10 of 498 patients (2.1%) in the fixed-dose group (subdistribution hazard ratio, 0.59; 95% CI, 0.22-1.63; P = 0.31). There was a twofold increased risk of major or clinically relevant nonmajor bleeding: 5.9% in the weight-adjusted dose group and 3.1% in the fixed-dose group (P = 0.034).Interpretation: In the COVI-DOSE trial, the observed rate of thromboembolic events was lower than expected in patients hospitalized for COVID-19 infection, and the study was unable to show a significant difference in the risk of venous thromboembolism between the two low-molecular-weight-heparin regimens.

Published
2023
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40. Accuracy of citrulline, I-FABP and d-lactate in the diagnosis of acute mesenteric ischemia

Author

Katell Peoc'h, Alexy Tran-Dinh, Nathalie Gault, Yoram Bouhnik, Kevin Guedj, Antonino Nicoletti, Yves Castier, Claude Hercend, Alexandre Nuzzo, Olivier Corcos, Maxime Ronot, Claude Bendavid, Sonja Curac, Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Université Sorbonne Paris Nord, Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Pontchaillou [Rennes], AP-HP - Hôpital Bichat - Claude Bernard [Paris], Centre d'investigation Clinique [CHU Bichat] - Épidémiologie clinique (CIC 1425), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), SURVI (Structure d’URgences Vasculaires Intestinales) Research Group (French Intestinal Stroke Center): Audrey Huguet, Carmen Stefanescu, Xavier Treton, Francisca Joly, Lore Billiauws, Annick Hamon, Aureline Boitet, Céline Lekhal, David Deutsch, Elsa Oiknin, Laura Cohen, Gabriel Marcellier, Jean Senemaud, Felix Corre, Damien Soudan, Cosmin Voican, Jean-Baptiste Leclère, Jules Iquilles, Lucas Raynaud, Luisa Paulatto, Manon Haas, Mathieu Uzzan, Mathilde Cohen, Sara Tadbiri, Servane Prevot, Yves Panis, Alice Frontali, Simon Msika, Lara Ribeiro, Lionel Rebibo, Konstantinos Arapis, Marion Orville, Annie Sibert, Pauline Copin, Magaly Zappa, Marco Dioguardi Burgio, Valérie Vilgrain, Caroline Bertin, Anne Kerbaol, Wassim Allaham, Quentin Pellenc, Arnaud Roussel, Pierre Cerceau, Iannis Ben Abdallah, Antoine Girault, Pierre Mordant, Romain De Blic, Catherine Paugam, Emmanuel Weiss, Paer-Selim Abback, Isabelle Enriquez, Sylvie Janny, Helene Bout, Mikhael Giabicani, Marina Achouf, Bénédicte Grigoresco, Linda Koy Ear, Sonja Curac, Agnès Cachier, Aurelie Plessier, Pierre-Emmanuel Rautou, Dominique Valla, Audrey Payancé, Alain Sauvanet, Safi Dokmak, Federica Dondero, Ailton Sepulveda, Olivier Farges, Beatrice Aussilhou, Bénédicte Jais, Dominique Cazals-Hatem, Emmanuelle De Raucourt, Larbi Boudaoud, Catherine Trichet, Herve Puy, Nathalie Pons-Kerjean, Jeanick Stocco, Julie Bataille, Valérie Bouton, Philippe Montravers, Pascal Augustin, Brice Lortat Jacob, Jean-Baptiste Michel, Dominique Gauguier, Marc-Emmanuel Dumas, François Brial, Antonis Myridakis, Laura Martinez-Gili, Michael Olanipekun, Estelle Marcault, Cindie Nilusmas, Anne Barnier, Aminata Souare, Grants from MSD-Avenir and APHP funded the SURVIBIO study, Alexandre Nuzzo received Ph.D. Grants from 'Fondation de l'Avenir' and the French Gastroenterology Society (SNFGE)., Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), and Jonchère, Laurent

Subjects
Male, [SDV]Life Sciences [q-bio], Statistical difference, Acute abdominal pain, Diseases, Gastroenterology, chemistry.chemical_compound, 0302 clinical medicine, Acute mesenteric ischemia, Citrulline, Stroke, Abdomen, Acute, Multidisciplinary, PLASMA CITRULLINE, CELIAC-DISEASE, Middle Aged, ACID-BINDING-PROTEIN, 3. Good health, Multidisciplinary Sciences, [SDV] Life Sciences [q-bio], 030220 oncology & carcinogenesis, Science & Technology - Other Topics, Medicine, Biomarker (medicine), Female, 030211 gastroenterology & hepatology, Adult, medicine.medical_specialty, VILLOUS ATROPHY, Science, Cardiology, Fatty Acid-Binding Proteins, Article, INTESTINAL ISCHEMIA, 03 medical and health sciences, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, Internal medicine, MANAGEMENT, medicine, Humans, Lactic Acid, cardiovascular diseases, Aged, Science & Technology, business.industry, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, medicine.disease, SERUM D(-)-LACTATE LEVELS, SURVI (Structure d’URgences Vasculaires Intestinales) Research Group (French Intestinal Stroke Center), Circulating biomarkers, SEROLOGICAL MARKERS, Cross-Sectional Studies, Early Diagnosis, chemistry, Mesenteric Ischemia, ENTEROCYTE MASS, Tomography, X-Ray Computed, D lactate, business, Biomarkers
Abstract

Early diagnosis of acute mesenteric ischemia (AMI) remains a clinical challenge, and no biomarker has been consistently validated. We aimed to assess the accuracy of three promising circulating biomarkers for diagnosing AMI—citrulline, intestinal fatty acid-binding protein (I-FABP), and d-lactate. A cross-sectional diagnostic study enrolled AMI patients admitted to the intestinal stroke center and controls with acute abdominal pain of another origin. We included 129 patients—50 AMI and 79 controls. Plasma citrulline concentrations were significantly lower in AMI patients compared to the controls [15.3 μmol/L (12.0–26.0) vs. 23.3 μmol/L (18.3–29.8), p = 0.001]. However, the area under the receiver operating curves (AUROC) for the diagnosis of AMI by Citrulline was low: 0.68 (95% confidence interval = 0.58–0.78). No statistical difference was found in plasma I-FABP and plasma d-lactate concentrations between the AMI and control groups, with an AUROC of 0.44, and 0.40, respectively. In this large cross-sectional study, citrulline, I-FABP, and d-lactate failed to differentiate patients with AMI from patients with acute abdominal pain of another origin. Further research should focus on the discovery of new biomarkers.

Published
2021
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