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1. Sepsis-induced coagulopathy in preterm neonates with Gram-positive sepsis presents with hypercoagulation and reduced platelet activation compared with healthy preterm neonates

Author

Gialamprinou, Dimitra, Kontovazainitis, Christos-Georgios, Pouliakis, Abraham, Fleva, Alexandra, Markopoulou, Maria, Bessina, Maria–Elina, Katsaras, Georgios N., Chatziioannidis, Ilias, Giannakou, Anastasia, Roilides, Emmanuel, Diamanti, Elisavet, and Mitsiakos, Georgios

Published
2023
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2. Perspectives on the Use of Echinocandins in the Neonatal Intensive Care Unit.

Author

Dermitzaki, Niki, Balomenou, Foteini, Gialamprinou, Dimitra, Giapros, Vasileios, Rallis, Dimitrios, and Baltogianni, Maria

Subjects
NEONATAL intensive care units, LOW birth weight, CASPOFUNGIN, ANTIFUNGAL agents, CANDIDIASIS
Abstract

The neonatal intensive care unit (NICU) population, especially low birth weight and critically ill neonates, is at risk of invasive Candida infections, which are associated with high mortality rates and unfavorable long-term outcomes. The timely initiation of an appropriate antifungal treatment has been demonstrated to enhance the prognosis. Factors that should be considered in the choice of an antifungal agent include the causative Candida strain, the presence and location of deep tissue infection, any previous use of antifungal prophylaxis, and the presence of implanted devices. Amphotericin B and fluconazole, the first-line drugs for neonatal candidiasis, are not always suitable due to several limitations in terms of efficacy and adverse effects. Therefore, alternative antifungals have been studied and used in neonates when conventional antifungals are ineffective or contraindicated. This narrative review aims to provide an overview of the current literature regarding the use of echinocandins in the neonatal population. The three echinocandins, micafungin, caspofungin, and anidulafungin, share characteristics that make them useful for the treatment of neonatal candidiasis, including activity against a wide range of Candida strains and Candida biofilms and a favorable safety profile. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Effect of spironolactone on pharmacological treatment of nonalcoholic fatty liver disease

Author

PAPAEFTHYMIOU, Apostolis, primary, DOULBERIS, Michael, additional, KARAFYLLIDOU, Kyriaki, additional, CHATZIMICHAEL, Eleftherios, additional, DERETZI, Georgia, additional, EXADAKTYLOS, Aristomenis K., additional, SAMPSONAS, Fotios, additional, GELASAKIS, Athanasios, additional, PAPAMICHOS, Spyros I., additional, KOTRONIS, Georgios, additional, GIALAMPRINOU, Dimitra, additional, VARDAKA, Elisabeth, additional, POLYZOS, Stergios A., additional, and KOUNTOURAS, Jannis, additional

Published
2023
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12. Combined Anticoagulant Therapy for Prevention of Preeclampsia and Small for Gestational Age Neonates: A Systematic Review and Meta-analysis.

Author

Kontovazainitis, Christos-Georgios, Gialamprinou, Dimitra, Katsaras, Georgios N., Pouliakis, Abraham, Theodoridis, Theodoros, and Mitsiakos, Georgios

Subjects
*PREECLAMPSIA prevention, *ONLINE information services, *MEDICAL databases, *ENOXAPARIN, *PUBLICATION bias, *COMBINATION drug therapy, *META-analysis, *MEDICAL information storage & retrieval systems, *PREMATURE infants, *CONFIDENCE intervals, *SYSTEMATIC reviews, *ANTICOAGULANTS, *PREECLAMPSIA, *LOW-molecular-weight heparin, *ASPIRIN, *QUALITY assurance, *DESCRIPTIVE statistics, *MEDLINE, *ODDS ratio, *SMALL for gestational age, *GREY literature
Abstract

Objective This systematic review and meta-analysis (SRMA) aims to compare the efficacy of combining low molecular weight heparin (LMWH) and aspirin against aspirin alone in preventing preeclampsia (PE) and small for gestational age (SGA) neonates in women at moderate and high risks. Study Design The included studies were nonrandomized and randomized clinical trials (RCTs) enrolling women at moderate and high risks for developing preeclampsia. PubMed/Medline, Cochrane Library, Embase, and Grey literature (including ClinicalTrials.gov) were searched. Results Out of 4,762 records, 7 nonrandomized studies and 12 RCTs (enrolling 545 and 1,677 women, respectively) were selected. Although the studies were clinically heterogeneous, the conduction of quantitative analysis was feasible. Regarding RCTs, the odds of early-onset preeclampsia was reduced by 89% (pooled odds ratio [OR] = 0.11, 95% confidence interval [CI]: 0.01–0.93, p = 0.04) in women with thrombophilia, the incidence of SGA neonates below the 5th percentile by 48% (pooled OR = 0.52, 95% CI: 0.28–0.96, p = 0.04) in women with a history of preeclampsia and/or SGA neonates, and the incidence of SGA neonates below the 10th percentile by 31% (pooled OR = 0.69, 95% CI: 0.50–0.96, p = 0.03) in the whole population. Conclusion Concerning the whole studied population, combined anticoagulant therapy is not superior to aspirin alone. However, it may be more effective in preventing early-onset preeclampsia regarding women with thrombophilia, SGA neonates below the 5th percentile regarding women with a history of preeclampsia and/or SGA, and SGA neonates below the 10th percentile in moderate- or high-risk women. The above mixed but promising results need to be envisaged with caution due to the clinical heterogeneity of the included studies which is the main limitation of our research. Nevertheless, the strict and narrow inclusion search criteria, and the appropriate subgroup analysis are its main strengths. More RCTs with homogeneous populations and stricter inclusion criteria are needed to confirm these results. Key Points Combined therapy is not superior to aspirin alone. Combined therapy in women with thrombophilia may protect against early-onset preeclampsia. Combined therapy in moderate/high-risk women may protect against SGA <10th percentile neonates. [ABSTRACT FROM AUTHOR]

Published
2023
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16. Impact of nonalcoholic fatty liver disease-related metabolic state on depression

Author

Ntona, Smaragda, primary, Papaefthymiou, Apostolis, additional, Kountouras, Jannis, additional, Gialamprinou, Dimitra, additional, Kotronis, Georgios, additional, Boziki, Marina, additional, Polyzos, Stergios A., additional, Tzitiridou, Maria, additional, Chatzopoulos, Dimitrios, additional, Thavayogarajah, Tharshika, additional, Gkolia, Ioanna, additional, Ntonas, Georgios, additional, Vardaka, Elisabeth, additional, and Doulberis, Michael, additional

Published
2023
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18. A potential impact of Helicobacter pylori–related metabolic syndrome on early and long-term outcomes of bariatric surgery

Author

Kountouras, Jannis, primary, Doulberis, Michael, additional, Polyzos, Stergios A., additional, Tzitiridou, Maria, additional, Chatzopoulos, Dimitrios, additional, Gialamprinou, Dimitra, additional, Kotronis, Georgios, additional, Vardaka, Elisabeth, additional, Liatsos, Christos, additional, and Papaefthymiou, Apostolis, additional

Published
2022
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20. Adverse Outcomes of E-cigarette in Inflammatory Bowel Disease

Author

Kountouras, Jannis, primary, Papaefthymiou, Apostolis, additional, Polyzos, Stergios A., additional, Liatsos, Christos, additional, Tzitiridou-Chatzopoulou, Maria, additional, Chatzopoulos, Dimitrios, additional, Vardaka, Elisabeth, additional, Gialamprinou, Dimitra, additional, Kotronis, Georgios, additional, Thavayogarajah, Tharshika, additional, and Doulberis, Michael, additional

Published
2022
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21. Comments on “dose-related meta-analysis for omega-3 fatty acids supplementation on major adverse cardiovascular events”

Author

Kountouras, Jannis, primary, Papaefthymiou, Apostolis, additional, Liatsos, Christos, additional, Tzitiridou-Chatzopoulou, Maria, additional, Chatzopoulos, Dimitrios, additional, Gialamprinou, Dimitra, additional, Kotronis, Georgios, additional, Vardaka, Elisabeth, additional, Kazakos, Evangelos, additional, and Doulberis, Michael, additional

Published
2022
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22. Neonatal haemostatic parameters in correlation to gestational age and birth weight

Author

Mitsiakos, Georgios, primary, Katsaras, Georgios N., additional, Pouliakis, Abraham, additional, Papadakis, Emmanouil, additional, Chatziioannidis, Ilias, additional, Mitsiakou, Christina, additional, Gialamprinou, Dimitra, additional, Papacharalampous, Efthimia, additional, Kioumi, Anna, additional, Athanasiou, Miranda, additional, Athanassiadou, Fani, additional, Sfoungaris, Dimitrios, additional, and Nikolaidis, Nikolaos, additional

Published
2022
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24. Potential Impact of Active H. pylori Infection-Related Metabolic Syndrome on Preeclampsia Among Pregnant Women [Letter]

Author

Tzitiridou-Chatzopoulou,Maria, Gialamprinou,Dimitra, Kountouras,Jannis, Tzitiridou-Chatzopoulou,Maria, Gialamprinou,Dimitra, and Kountouras,Jannis

Abstract

Maria Tzitiridou-Chatzopoulou,1,2 Dimitra Gialamprinou,3 Jannis Kountouras1 1Department of Medicine, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Macedonia, Greece; 2School of Healthcare Sciences, Midwifery Department, University of West Macedonia, Kozani, Macedonia, 50100, Greece; 3Second Neonatal Department and NICU, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Thessaloniki, Macedonia, 56403, GreeceCorrespondence: Jannis Kountouras, Professor of Medicine, Gastroenterologist, 8 Fanariou St, Byzantio, Thessaloniki, Macedonia, 551 33, Greece, Tel +30-2310-892238, Fax +30-2310-892744, Email jannis@auth.gr; ancoratus2010@gmail.com View the original paper by Dr Tsegaye and colleagues

Published
2022

28. Ofeleein i mi Vlaptin—Volume II: Immunity Following Infection or mRNA Vaccination, Drug Therapies and Non-Pharmacological Management at Post-Two Years SARS-CoV-2 Pandemic

Author

Kountouras, Jannis, primary, Gialamprinou, Dimitra, additional, Kotronis, Georgios, additional, Papaefthymiou, Apostolis, additional, Economidou, Eleftheria, additional, Soteriades, Elpidoforos S., additional, Vardaka, Elisabeth, additional, Chatzopoulos, Dimitrios, additional, Tzitiridou-Chatzopoulou, Maria, additional, Papazoglou, Dimitrios David, additional, and Doulberis, Michael, additional

Published
2022
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29. Neonatal Sepsis and Hemostasis

Author

Gialamprinou, Dimitra, primary, Mitsiakos, Georgios, additional, Katsaras, Georgios N., additional, Kontovazainitis, Christos-Georgios, additional, Karagianni, Paraskevi, additional, Roilides, Emmanuel, additional, and Kenet, Gili, additional

Published
2022
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30. Optimised versus standard dosing of vancomycin in infants with Gram-positive sepsis (NeoVanc): a multicentre, randomised, open-label, phase 2b, non-inferiority trial

Author

Hill, Louise F, primary, Clements, Michelle N, additional, Turner, Mark A, additional, Donà, Daniele, additional, Lutsar, Irja, additional, Jacqz-Aigrain, Evelyne, additional, Heath, Paul T, additional, Roilides, Emmanuel, additional, Rawcliffe, Louise, additional, Alonso-Diaz, Clara, additional, Baraldi, Eugenio, additional, Dotta, Andrea, additional, Ilmoja, Mari-Liis, additional, Mahaveer, Ajit, additional, Metsvaht, Tuuli, additional, Mitsiakos, George, additional, Papaevangelou, Vassiliki, additional, Sarafidis, Kosmas, additional, Walker, A Sarah, additional, Sharland, Michael, additional, Hill, Louise F, additional, Clements, Michelle, additional, Bafadal, Basma, additional, Alarcon Allen, Ana, additional, Anatolitou, Fani, additional, Del Vecchio, Antonio, additional, Giuffrè, Mario, additional, Karachristou, Korina, additional, Manzoni, Paolo, additional, Martinelli, Stefano, additional, Moriarty, Paul, additional, Nika, Angeliki, additional, Papaevangelou, Vana, additional, Roehr, Charles, additional, Sanchez Alcobendas, Laura, additional, Siahanidou, Tania, additional, Tzialla, Chryssoula, additional, Bonadies, Luca, additional, Booth, Nicola, additional, Catalina Morales-Betancourt, Paola, additional, Cordeiro, Malaika, additional, de Alba Romero, Concha, additional, de la Cruz, Javier, additional, De Luca, Maia, additional, Farina, Daniele, additional, Franco, Caterina, additional, Gialamprinou, Dimitra, additional, Hallik, Maarja, additional, Ilardi, Laura, additional, Insinga, Vincenzo, additional, Iosifidis, Elias, additional, Kalamees, Riste, additional, Kontou, Angeliki, additional, Molnar, Zoltan, additional, Nikaina, Eirini, additional, Petropoulou, Chryssoula, additional, Reyné, Mar, additional, Tataropoulou, Kassandra, additional, Triantafyllidou, Pinelopi, additional, Vontzalidis, Adamantios, additional, and Sharland, Mike, additional

Published
2022
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31. Thromboelastometry in Neonates with Respiratory Distress Syndrome: A Pilot Study

Author

Katsaras, Georgios N., primary, Sokou, Rozeta, additional, Tsantes, Andreas G., additional, Konstantinidi, Aikaterini, additional, Gialamprinou, Dimitra, additional, Piovani, Daniele, additional, Bonovas, Stefanos, additional, Kriebardis, Anastasios G., additional, Mitsiakos, Georgios, additional, Kokoris, Styliani, additional, and Tsantes, Argirios E., additional

Published
2021
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34. Are neonatal outcomes of triplet pregnancies different from those of singletons according to gestational age?

Author

Mitsiakos, Georgios Gialamprinou, Dimitra Chatziioannidis, Ilias and Pouliakis, Abraham Kontovazainitis, Christos Georgios and Chatzigrigoriou, Fotini Karagkiozi, Anastasia Lazaridou, Eleni and Papacharalambous, Efthimia Poumpouridou, Effimia and Theodoridis, Theodoros Babacheva, Evgenyia Karagianni, Paraskevi and Grimbizis, Grigorios Soubasi, Vassiliki

Subjects
macromolecular substances, reproductive and urinary physiology
Abstract

Objectives: Multiple pregnancies sustain the high pace of extreme prematurity. Little evidence is available about triplet gestation given the evolution in their management during the last decades. The aim of the study was to compare the neonatal outcomes of triplets with those of matched singletons in a cohort study. Methods: An observational retrospective cohort study of triplets and matched singletons born between 2004 and 2017 matched by gestational age was conducted. Additionally, the investigation performed in regard to data from the overall Greek population of interest. The primary outcome was mortality or severe neonatal morbidity based on pregnancy type. Results: A total of 237 triplets of 24-36 weeks’ gestation and 482 matched singletons were included. No differences in the primary outcome between triplets and singletons were found. Rates of severe neonatal morbidities did not differ significantly between triplets and singletons. A threshold of 1000 gr for birthweight and 28 weeks’ gestation for gestational age determined survival on triplets [OR: 0.08 (95% CI: 0.02-0.40, p=0.0020) and OR: 0.13 (95% CI: 0.03-0.57, p=0.0020) for gestational age and birthweight respectively]. In Greece stillbirths in triplets was 8 times higher than that of singletons (OR: 8.5, 95% CI: 6.9-10.5). From 3,375 triplets, 94 were stillborn, whereas in singletons, 4,659 out of 1,388,273. In our center 5 times more triplets than the expected average in Greece were delivered with no significant difference in stillbirths’ rates. Conclusions: No significant differences were identified in mortality or major neonatal morbidities between triplets and matched singletons highlighting the significance of prematurity and birthweight for these outcomes.

Published
2021

35. The use of thromboelastography (TEG) and rotational thromboelastometry (ROTEM) in neonates: a systematic review

Author

Katsaras, Georgios N. Sokou, Rozeta Tsantes, Andreas G. and Piovani, Daniele Bonovas, Stefanos Konstantinidi, Aikaterini and Ioakeimidis, Georgios Parastatidou, Stauroula Gialamprinou, Dimitra Makrogianni, Athanasia Mitsiakos, Georgios Tsantes, Argirios E.

Abstract

“Developmental hemostasis” refers to the dynamic process of gradual hemostatic maturation. Conventional coagulation tests seem to fail to accurately depict the in vivo hemostasis, while viscoelastic tests, thromboelastography (TEG), and rotational thromboelastometry (ROTEM) appear very promising as they provide insight more rapidly and accurately into the hemostatic potential. We systematically reviewed the literature in PubMed to examine the use of TEG and ROTEM in neonates. Our search yielded 34 studies, of which 18 concerned healthy neonates and 16 sick neonates. These viscoelastic tests have shown accelerated initiation of coagulation, increased clot strength, and increased fibrinolysis in healthy neonates compared to children and adults. Cord blood leads to a hypercoagulable state as compared to whole blood when testing is performed with TEG. Pre-term neonates have a more hypocoagulable profile, but balanced hemostasis, related to term neonates, that evolves to a more procoagulant phenotype over the first month of life. Critically ill neonates exhibit a more hypocoagulable profile as compared to healthy neonates. TEG and ROTEM have shown predictive value for bleeding events in critically ill neonates and neonates undergoing cardiopulmonary bypass or therapeutic hypothermia. Conclusion: TEG and ROTEM need to become part of the standard coagulation assessment in clinical settings in which hemostatic abnormalities are involved, as they seem to provide more rapid and accurate information regarding the hemostatic profile of the neonates. Their predictive value for bleeding events in critically ill neonates could lead to a more targeted therapy optimizing utilization of blood products.

Published
2021

36. Thromboelastometry in Neonates with Respiratory Distress Syndrome: A Pilot Study

Author

Katsaras, Georgios N. Sokou, Rozeta Tsantes, Andreas G. Konstantinidi, Aikaterini Gialamprinou, Dimitra Piovani, Daniele Bonovas, Stefanos Kriebardis, Anastasios G. Mitsiakos, Georgios Kokoris, Styliani Tsantes, Argirios E.

Abstract

BACKGROUND: Although respiratory distress syndrome (RDS) constitutes a postnatal risk factor for bleeding and thromboembolic events in neonates, few studies have addressed this issue. We aimed to evaluate the hemostatic profile of neonates with RDS using rotational thromboelastometry (ROTEM). METHODS: An observational study was conducted from November 2018 to November 2020 in the NICU of General Hospital of Nikaia "Aghios Panteleimon". Preterm and term neonates with RDS hospitalized in the NICU were included and EXTEM (tissue factor-triggered extrinsic pathway), INTEM (ellagic acid activated intrinsic pathway), and FIBTEM (with platelet inhibitor cytochalasin D) assays were performed at the onset of the disease. RESULTS: A hypocoagulable profile was noted in neonates with RDS compared to controls, expressed as significant prolongation of EXTEM CT (clotting time) and CFT (clot formation time), lower EXTEM A10 (amplitude at 10 min), MCF (maximum clot firmness), and LI60 (lysis index). Furthermore, prolongation of INTEM CFT and FIBTEM CT, and decreased INTEM and FIBTEM A10 and MCF were found in neonates with RDS. Multivariable logistic regression analysis showed that RDS is an independent factor for the recorded alterations in ROTEM variables. CONCLUSIONS: RDS is associated with a hypocoagulable profile and greater hyperfibrinolytic potential compared to healthy neonates.

Published
2021

37. Are neonatal outcomes of triplet pregnancies different from those of singletons according to gestational age?

Author

Mitsiakos, Georgios, primary, Gialamprinou, Dimitra, additional, Chatziioannidis, Ilias, additional, Pouliakis, Abraham, additional, Kontovazainitis, Christos Georgios, additional, Chatzigrigoriou, Fotini, additional, Karagkiozi, Anastasia, additional, Lazaridou, Eleni, additional, Papacharalambous, Efthimia, additional, Poumpouridou, Effimia, additional, Theodoridis, Theodoros, additional, Babacheva, Evgenyia, additional, Karagianni, Paraskevi, additional, Grimbizis, Grigorios, additional, and Soubasi, Vassiliki, additional

Published
2021
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38. Does COVID-19 Vaccination Warrant the Classical Principle ' ofelein i mi vlaptin'?

Author

Doulberis, Michael; https://orcid.org/0000-0002-0396-5081, Papaefthymiou, Apostolis; https://orcid.org/0000-0002-3563-4973, Kotronis, Georgios, Gialamprinou, Dimitra, Soteriades, Elpidoforos S, Kyriakopoulos, Anthony; https://orcid.org/0000-0002-0749-0060, Chatzimichael, Eleftherios, Kafafyllidou, Kyriaki, Liatsos, Christos; https://orcid.org/0000-0001-8025-0808, Chatzistefanou, Ioannis; https://orcid.org/0000-0001-7463-6106, Anagnostis, Paul, Semenin, Vitalii, Ntona, Smaragda, Gkolia, Ioanna, Papazoglou, Dimitrios David, Tsinonis, Nikolaos, Papamichos, Spyros; https://orcid.org/0000-0001-7119-0647, Kirbas, Hristos, Zikos, Petros, Niafas, Dionisios, Kountouras, Jannis, Doulberis, Michael; https://orcid.org/0000-0002-0396-5081, Papaefthymiou, Apostolis; https://orcid.org/0000-0002-3563-4973, Kotronis, Georgios, Gialamprinou, Dimitra, Soteriades, Elpidoforos S, Kyriakopoulos, Anthony; https://orcid.org/0000-0002-0749-0060, Chatzimichael, Eleftherios, Kafafyllidou, Kyriaki, Liatsos, Christos; https://orcid.org/0000-0001-8025-0808, Chatzistefanou, Ioannis; https://orcid.org/0000-0001-7463-6106, Anagnostis, Paul, Semenin, Vitalii, Ntona, Smaragda, Gkolia, Ioanna, Papazoglou, Dimitrios David, Tsinonis, Nikolaos, Papamichos, Spyros; https://orcid.org/0000-0001-7119-0647, Kirbas, Hristos, Zikos, Petros, Niafas, Dionisios, and Kountouras, Jannis

Abstract

The current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic warrants an imperative necessity for effective and safe vaccination, to restrain Coronavirus disease 2019 (COVID-19) including transmissibility, morbidity, and mortality. In this regard, intensive medical and biological research leading to the development of an arsenal of vaccines, albeit incomplete preconditioned evaluation, due to emergency. The subsequent scientific gap raises some concerns in the medical community and the general public. More specifically, the accelerated vaccine development downgraded the value of necessary pre-clinical studies to elicit medium- and long-term beneficial or harmful consequences. Previous experience and pathophysiological background of coronaviruses' infections and vaccine technologies, combined with the global vaccines' application, underlined the obligation of a cautious and qualitative approach, to illuminate potential vaccination-related adverse events. Moreover, the high SARS-CoV-2 mutation potential and the already aggregated genetical alterations provoke a rational vagueness and uncertainty concerning vaccines' efficacy against dominant strains and the respective clinical immunity. This review critically summarizes existing evidence and queries regarding SARS-CoV-2 vaccines, to motivate scientists' and clinicians' interest for an optimal, individualized, and holistic management of this unprecedented pandemic.

Published
2021

39. Does COVID-19 Vaccination Warrant the Classical Principle “ofelein i mi vlaptin”?

Author

Doulberis, Michael, primary, Papaefthymiou, Apostolis, additional, Kotronis, Georgios, additional, Gialamprinou, Dimitra, additional, Soteriades, Elpidoforos S., additional, Kyriakopoulos, Anthony, additional, Chatzimichael, Eleftherios, additional, Kafafyllidou, Kyriaki, additional, Liatsos, Christos, additional, Chatzistefanou, Ioannis, additional, Anagnostis, Paul, additional, Semenin, Vitalii, additional, Ntona, Smaragda, additional, Gkolia, Ioanna, additional, Papazoglou, Dimitrios David, additional, Tsinonis, Nikolaos, additional, Papamichos, Spyros, additional, Kirbas, Hristos, additional, Zikos, Petros, additional, Niafas, Dionisios, additional, and Kountouras, Jannis, additional

Published
2021
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44. Impact of Helicobacter pylori and/or Helicobacter pylori-related metabolic syndrome on gastroesophageal reflux disease- Barrett's esophagus- esophageal adenocarcinoma sequence

Author

Doulberis, Michael, Kountouras, Jannis, Polyzos, Stergios A, Tzivras, Dimitri, Vardaka, Elizabeth, Kountouras, Constantinos, Tzilves, Dimitrios, Kotronis, Georgios, Boutsikou, Efimia, Gialamprinou, Dimitra, Exadaktylos, Aristomenis, and Katsinelos, Panagiotis

Subjects
610 Medicine & health
Published
2018
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45. Acute Liver Failure

Author

Doulberis, Michael, primary, Kotronis, Georgios, additional, Gialamprinou, Dimitra, additional, Özgüler, Onur, additional, Exadaktylos, Aristomenis K., additional, Oikonomou, Vasileios, additional, Katsinelos, Panagiotis, additional, Romiopoulos, Iordanis, additional, Polyzos, Stergios A., additional, Tzivras, Dimitri, additional, Deretzi, Georgia, additional, Dardiotis, Efthimios, additional, and Kountouras, Jannis, additional

Published
2019
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46. Impact of Helicobacter pylori and/or Helicobacter pylori‐ related metabolic syndrome on gastroesophageal reflux disease‐ Barrett's esophagus‐ esophageal adenocarcinoma sequence

Author

Doulberis, Michael, primary, Kountouras, Jannis, additional, Polyzos, Stergios A., additional, Tzivras, Dimitri, additional, Vardaka, Elizabeth, additional, Kountouras, Constantinos, additional, Tzilves, Dimitrios, additional, Kotronis, Georgios, additional, Boutsikou, Efimia, additional, Gialamprinou, Dimitra, additional, Exadaktylos, Aristomenis, additional, and Katsinelos, Panagiotis, additional

Published
2018
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49. Review: Impact of <italic>Helicobacter pylori</italic> on Alzheimer's disease: What do we know so far?

Author

Doulberis, Michael, Kotronis, Georgios, Thomann, Robert, Polyzos, Stergios A., Boziki, Marina, Gialamprinou, Dimitra, Deretzi, Georgia, Katsinelos, Panagiotis, and Kountouras, Jannis

Subjects
HELICOBACTER pylori, ALZHEIMER'S disease, EPIDEMIOLOGY, BLOOD-brain barrier, RANDOMIZED controlled trials, PATHOLOGICAL physiology
Abstract

Abstract: Background: Helicobacter pylori has changed radically gastroenterologic world, offering a new concept in patients' management. Over time, more medical data gave rise to diverse distant, extragastric manifestations and interactions of the “new” discovered bacterium. Special interest appeared within the field of neurodegenerative diseases and particularly Alzheimer's disease, as the latter and Helicobacter pylori infection are associated with a large public health burden and Alzheimer's disease ranks as the leading cause of disability. However, the relationship between Helicobacter pylori infection and Alzheimer's disease remains uncertain. Methods: We performed a narrative review regarding a possible connection between Helicobacter pylori and Alzheimer's disease. All accessible relevant (pre)clinical studies written in English were included. Both affected pathologies were briefly analyzed, and relevant studies are discussed, trying to focus on the possible pathogenetic role of this bacterium in Alzheimer's disease. Results: Data stemming from both epidemiologic studies and animal experiments seem to be rather encouraging, tending to confirm the hypothesis that Helicobacter pylori infection might influence the course of Alzheimer's disease pleiotropically. Possible main mechanisms may include the bacterium's access to the brain via the oral‐nasal‐olfactory pathway or by circulating monocytes (infected with Helicobacter pylori due to defective autophagy) through disrupted blood‐brain barrier, thereby possibly triggering neurodegeneration. Conclusions: Current data suggest that Helicobacter pylori infection might influence the pathophysiology of Alzheimer's disease. However, further large‐scale randomized controlled trials are mandatory to clarify a possible favorable effect of Helicobacter pylori eradication on Alzheimer's disease pathophysiology, before the recommendation of short‐term and cost‐effective therapeutic regimens against Helicobacter pylori‐related Alzheimer's disease. [ABSTRACT FROM AUTHOR]

Published
2018
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50. Alzheimer's disease and gastrointestinal microbiota; impact of Helicobacter pylori infection involvement.

Author

Doulberis M, Kotronis G, Gialamprinou D, Polyzos SA, Papaefthymiou A, Katsinelos P, and Kountouras J

Subjects
Alzheimer Disease epidemiology, Alzheimer Disease microbiology, Blood-Brain Barrier metabolism, Blood-Brain Barrier microbiology, Brain microbiology, Helicobacter Infections epidemiology, Helicobacter pylori isolation & purification, Humans, Inflammation Mediators metabolism, Alzheimer Disease metabolism, Brain metabolism, Gastrointestinal Microbiome physiology, Helicobacter Infections metabolism, Helicobacter pylori metabolism
Abstract

Background: Alzheimer disease (AD) is a leading cause of global burden with great impact on societies. Although research is working intensively on promising therapy, the problem remains up-to-date. Among the various proposed hypotheses regarding causality and therapy, emerging evidence supports the hypothesis that gastrointestinal microbiota through the so-called 'gut-brain axis' interacts with immune system and brain and shape the balance between homeostasis and disease; the involvement of gastrointestinal microbiota in the pathophysiology of AD is less defined, even though the role of 'gut-brain axis' has been well verified for other neurodegenerative conditions. Methods: We performed a systematic review of PubMed/MEDLINE database from 1 st January 1990 to 17 th October 2018, to investigate the accessible literature regarding possible association between AD and gastrointestinal microbiota. Inclusion criteria were available full text in English language, original clinical papers implicating AD patients and any sort of gastrointestinal microbiota. Results: Through our query, an initial number of 241 papers has been identified. After removing duplicates and through an additional manual search, twenty-four papers met our inclusion criteria. The great majority of eligible publications supported a possible connection between AD and gastrointestinal microbiota. The most common investigated microorganism was Helicobacter pylori. Conclusion: Our own systematic review, showed a possible association between AD and gastrointestinal microbiota mainly including Helicobacter pylori , and thus further research is required for substantiation of causality as well as for the establishment of promising novel therapies.

Published
2021
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