1. Physical comorbidities of older age bipolar disorder (OABD) patients: A global replication analysis of prevalence and sex differences.
- Author
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Teixeira, Antonio L., Almeida, Osvaldo P., Lavin, Paola, Barbosa, Izabela G., Alda, Martin, Altinbas, Kursat, Balanzá-Martínez, Vicent, Briggs, Farren B.S., Calkin, Cynthia, Chen, Peijun, Dols, Annemieke, Eyler, Lisa T., Forester, Brent P., Forlenza, Orestes V., Gildengers, Ariel G., Hajek, Tomas, Haarman, Benno, Korten, Nicole, Jimenez, Esther, and Lafer, Beny
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BIPOLAR disorder , *CARDIOVASCULAR diseases , *SEX distribution , *REPLICATION (Experimental design) , *MUSCULOSKELETAL system diseases , *GENITOURINARY diseases , *DESCRIPTIVE statistics , *ODDS ratio , *COMPARATIVE studies , *CONFIDENCE intervals , *KIDNEY diseases , *ENDOCRINE diseases , *COMORBIDITY , *GASTROINTESTINAL diseases , *DISEASE complications , *OLD age - Abstract
To compare the prevalence of physical morbidities between older aged patients with bipolar disorder (OABD) and non-psychiatric comparisons (NC), and to analyze sex differences in prevalence. OABD was defined as bipolar disorder among adults aged ≥50 years. Outcomes analyzed were the prevalence of diseases affecting the cardiovascular, respiratory, gastrointestinal, genitourinary, renal, musculoskeletal, and endocrine systems. The analysis used cross-sectional data of OABD participants (n = 878; mean age 60.9 ± 8.0 years, n = 496 (56%) women) from the collaborative Global Aging & Geriatric Experiments in Bipolar Disorder (GAGE-BD) dataset and NC participants recruited at the same sites (n = 355; mean age 64.4 ± 9.7 years, n = 215 (61%) women). After controlling for sex, age, education, and smoking history, the OABD group had more cardiovascular (odds ratio [95% confidence interval]: 2.12 [1.38–3.30]), renal (5.97 [1.31–43.16]), musculoskeletal (2.09 [1.30–3.43]) and endocrine (1.90 [1.20–3.05]) diseases than NC. Women with OABD had more gastrointestinal (1.56 [0.99–2.49]), genitourinary (1.72 [1.02–2.92]), musculoskeletal (2.64 [1.66–4.37]) and endocrine (1.71 [1.08–2.73]) comorbidities than men with OABD, when age, education, smoking history, and study site were controlled. This replication GAGE-BD study confirms previous findings indicating that OABD present more physical morbidities than matched comparison participants, and that this health burden is significantly greater among women. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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