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2 results on '"GCLQ"'

1. GOG 244 - The LymphEdema and Gynecologic cancer (LEG) study: The association between the gynecologic cancer lymphedema questionnaire (GCLQ) and lymphedema of the lower extremity (LLE)

Author

Carter, Jeanne, Huang, Helen Q, Armer, Jane, Carlson, Jay W, Lockwood, Suzy, Nolte, Susan, Stewart, Bob R, Kauderer, James, Hutson, Alan, Walker, Joan L, Fleury, Aimee C, Bonebrake, Albert, Soper, John T, Mathews, Cara, Zivanovic, Oliver, Richards, William Edwards, Tan, Annie, Alberts, David S, Barakat, Richard R, and Wenzel, Lari

Subjects
Clinical Research, Cervical Cancer, Uterine Cancer, Cancer, Adult, Aged, Aged, 80 and over, Female, Genital Neoplasms, Female, Gynecologic Surgical Procedures, Humans, Leg, Lymphedema, Middle Aged, Self Report, Surveys and Questionnaires, Endometrial cancer, Vulvar cancer, Cervical cancer, Gynecologic cancer lymphedema questionnaire, GCLQ, Oncology and Carcinogenesis, Paediatrics and Reproductive Medicine, Oncology & Carcinogenesis
Abstract

ObjectiveTo explore whether patient-reported lymphedema-related symptoms, as measured by the Gynecologic Cancer Lymphedema Questionnaire (GCLQ), are associated with a patient-reported diagnosis of lymphedema of the lower extremity (LLE) and limb volume change (LVC) in patients who have undergone radical surgery, including lymphadenectomy, for endometrial, cervical, or vulvar cancer on Gynecologic Oncology Group (GOG) study 244.MethodsPatients completed the baseline and at least one post-surgery GCLQ and LVC assessment. The 20-item GCLQ measures seven symptom clusters-aching, heaviness, infection-related, numbness, physical functioning, general swelling, and limb swelling. LLE was defined as a patient self-reported LLE diagnosis on the GCLQ. LVC was measured by volume calculations based on circumferential measurements. A linear mixed model was fitted for change in symptom cluster scores and GCLQ total score and adjusted for disease sites and assessment time.ResultsOf 987 eligible patients, 894 were evaluable (endometrial, 719; cervical, 136; vulvar, 39). Of these, 14% reported an LLE diagnosis (endometrial, 11%; cervical, 18%; vulvar, 38%). Significantly more patients diagnosed versus not diagnosed with LLE reported ≥4-point increase from baseline on the GCLQ total score (p 10% was significantly associated with reported general swelling (p

Published
2019

2. GOG 244 - The LymphEdema and Gynecologic cancer (LEG) study: The association between the gynecologic cancer lymphedema questionnaire (GCLQ) and lymphedema of the lower extremity (LLE)

Author

Bob R. Stewart, Aimee C. Fleury, William E. Richards, James Kauderer, Suzy Lockwood, Albert J. Bonebrake, David S. Alberts, Oliver Zivanovic, Richard R. Barakat, Alan D. Hutson, Annie Tan, Helen Q. Huang, Lari Wenzel, Cara Mathews, Jay W. Carlson, John T. Soper, Susan Nolte, Jeanne Carter, Joan L. Walker, and Jane M. Armer

Subjects
Adult, 0301 basic medicine, medicine.medical_specialty, Genital Neoplasms, Female, medicine.medical_treatment, Oncology and Carcinogenesis, Gynecologic oncology, Cervical Cancer, Article, Paediatrics and Reproductive Medicine, 03 medical and health sciences, Gynecologic Surgical Procedures, Uterine Cancer, 0302 clinical medicine, Endometrial cancer, Clinical Research, Surveys and Questionnaires, Internal medicine, Gynecologic cancer, 80 and over, medicine, Humans, GCLQ, Lymphedema, Oncology & Carcinogenesis, Radical surgery, Aged, Cancer, Aged, 80 and over, Cervical cancer, Leg, Vulvar cancer, business.industry, Obstetrics and Gynecology, Gynecologic cancer lymphedema questionnaire, Middle Aged, medicine.disease, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Female, Lymphadenectomy, Self Report, Genital Neoplasms, business
Abstract

ObjectiveTo explore whether patient-reported lymphedema-related symptoms, as measured by the Gynecologic Cancer Lymphedema Questionnaire (GCLQ), are associated with a patient-reported diagnosis of lymphedema of the lower extremity (LLE) and limb volume change (LVC) in patients who have undergone radical surgery, including lymphadenectomy, for endometrial, cervical, or vulvar cancer on Gynecologic Oncology Group (GOG) study 244.MethodsPatients completed the baseline and at least one post-surgery GCLQ and LVC assessment. The 20-item GCLQ measures seven symptom clusters-aching, heaviness, infection-related, numbness, physical functioning, general swelling, and limb swelling. LLE was defined as a patient self-reported LLE diagnosis on the GCLQ. LVC was measured by volume calculations based on circumferential measurements. A linear mixed model was fitted for change in symptom cluster scores and GCLQ total score and adjusted for disease sites and assessment time.ResultsOf 987 eligible patients, 894 were evaluable (endometrial, 719; cervical, 136; vulvar, 39). Of these, 14% reported an LLE diagnosis (endometrial, 11%; cervical, 18%; vulvar, 38%). Significantly more patients diagnosed versus not diagnosed with LLE reported ≥4-point increase from baseline on the GCLQ total score (p10% was significantly associated with reported general swelling (p&nbsp

Published
2019
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