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Abstract [Objective] The study aims to explore the changes of morphological, physiological, and biochemical indexes during the development of Notopterygium incisum seeds, and to provide theoretical basis for the introduction and domestication of N . incisum and the cultivation of high-quality germplasm resources. [Methods] The morphological, physiological, and biochemical indexes of N . incisum seeds at different developmental stages were determined by observation samplings and the frozen section method. [Results] During the development of N . incisum seeds, seed size and wing thickness were first increased and then decreased, while wing width was increased. The color of the outer seed coat was changed from bright blue-green to yellow-brown. The contents of starch, soluble sugar, and soluble protein were increased. Amylase activity was fluctuated in a small range; succinate dehydrogenase activity was increased; glucose-6-phosphate dehydrogenase activity was increased and decreased alternately; pyruvate kinase activity showed “M”-shape changes. POD activity was decreased while SOD activity was decreased. GA3, IAA, and ZR contents were decreased, while ABA contents were increased. The morphological indexes of the seeds were negatively correlated with the activity of SOD. The content of the storage materials was negatively correlated with the seed thickness, but positively correlated with the width of the fruit wings. [Conclusion] When N . incisum embryo is developed to pre-cardioid embryo, the outer seed coat is changed from blue-green to yellow-brown, the content of storage material is increased, and the activity of key enzymes is fluctuated and decreased. The content of growth-promoting hormones is fluctuated and decreased, while the content of stress hormones is increased.

The rise of AI and the increasing prominence of LLM are positioned as core technologies for knowledge dissemination and multi-turn dialogues. Alongside their growth, the high energy consumption associated with data processing, model training, and deployment in AI large models is necessitating effective evaluation to facilitate quantitative comparisons before and after model optimization. An assessment method for the energy consumption of AI large models was introduced, aimed at quantitatively evaluating the service efficiency (E) of AI models. This model was incorporated with multiple dimensions such as training convergence time (T), model parameter size (P), and floating-point operations (F), and quantitative analysis was achieved through the construction of an energy consumption function C(T, P, F). Furthermore, by employing the nonlinear least squares method, model parameters were derived. This analysis method was not only applicable to the operational efficiency analysis of AI models used by telecommunications operators but can also be generalized for energy consumption assessment of AI models across various industries.

Objective·To evaluate the dentofacial phenotype in non-syndromic tooth agenesis (NSTA) patients with paired box gene 9 (PAX9) mutation.Methods·Patients with NSTA who visited the Department of Second Dental Center of Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, between January 2016 and December 2023 received whole-exome sequencing to screen PAX9 mutation. The location and number of missing teeth were evaluated by oral pantomography, and dentofacial deformities were evaluated by X-ray cephalometrics.Results·Seven patients with PAX9 mutation were included in the study, including 3 males (42.9%) and 4 females (57.1%). The patients were 7‒31 years old at first visit, with a mean age of (19.7±8.0) years old. All the 7 patients were PAX9 heterozygotes, of which 4 were missense and 3 were frameshift. The average number of missing teeth was 15.9±2.9. The number of missing teeth in maxilla (9.6±2.6) was slightly higher than that in mandible (6.3±2.4) (P=0.030). Maxillary second molar (100.0%), maxillary canine (85.7%) and mandibular second premolar (85.7%) were the three most common missing teeth, while mandibular lateral incisor (14.3%) and mandibular canine (14.3%) were the two least missing teeth. Patients with frameshift mutation had more missing teeth (18.3±2.1) than those with missense mutation (14.0±1.8) (P=0.032). X-ray cephalometrics analysis results showed that the angle sella-nasion-subspinale (SNA), angle nasion-subspinale-subspinale-porion (NA-Apo) and sella-nasion (S-N) in adult patients with PAX9 mutation were significantly lower than the normal reference values, suggesting a shorter anterior cranial base and maxillary length. The frankfort horizontal plane-nasion-porion (FH-NPo) was higher than the reference value, and the Y-axis was lower than the reference value, indicating a more prognathic mandible. The angle subspinale-nasion-supramental (ANB) was lower than the reference value, indicating a skeletal angle Ⅲ malocclusion. The angle upper central incisor-nasion-subspinale (angle U1-NA) was higher than the reference value, indicating a lip inclination of maxillary central incisor. The angle lower central incisor-mandibular plane (IMPA) and lower central incisor-nasion-supramental (L1-NB) were lower than the reference values, indicating a retroclination of the mandibular central incisor, and crossbite in the maxillary and mandibular anterior teeth.Conclusion·The dentofacial phenotype of PAX9-mutated patients with NSTA is reported comprehensively. It is helpful to improve the understanding of the role of PAX9 in human maxillofacial development.

Objective To investigate the effect of cerebrospinal fluid (CSF) metagenomic next - generation sequencing (mNGS) in diagnosis and treatment of intracranial infection. Methods A retrospective analysis of 117 patients with intracranial infection were admitted to Shenzhen Second People's Hospital from January 2020 to December 2022. Before initiating empirical broad - spectrum antibiotic treatment, CSF samples were collected for microbial culture (conventional culture group, n = 58) and/or mNGS (mNGS group, n = 59). The results were used to adjust the antibiotic treatment plan, and the study compared the pathogen detection rates and result reporting times of the two testing methods, as well as the antibiotic intensity grading, the intensive care unit (ICU) stay, total hospital stay, and mortality rate. Results A total of 65 pathogens were detected from the CSF samples of all the patients through microbial culture and/or mNGS, with viruses being the most prevalent, accounting for 49.23% (32/65), followed by Gram-negative bacteria (24.62%, 16/65), Gram-positive bacteria (18.46%, 12/65) and fungi (7.69%, 5/65). The pathogen detection rate of CSF mNGS was higher than that of CSF microbial culture (χ2 = 22.781, P = 0.000), and the results were reported earlier (t = - 32.588, P = 0.000). Based on the results, 20 cases (33.90%) in the mNGS group adjusted antibiotic treatment plan, with 5 cases downgrading and 15 cases upgrading the intensity of antibiotic application. In the conventional culture group, 30 cases (51.72%) adjusted their antibiotic treatment plan, with 17 cases downgrading and 13 cases upgrading the intensity of antibiotic application. There was no significant difference between the 2 groups (Z = - 1.917, P = 0.055). And there was no statistically significant difference in ICU stay (Z = - 0.716, P = 0.474）, total hospital stay (Z = - 0.933, P = 0.351) and mortality rate (Fisher's exact probability: P = 0.496) between the 2 groups. Conclusions The application of mNGS can effectively improve the detection rate of intracranial infection pathogens, which may shorten the duration of antibiotic use and reduce the intensity of broad - spectrum antibiotics, so as to help clinical effective judgment and treatment decision.

Bacteriophages have been used across various fields, and the utilization of CRISPR/Cas-based genome editing technology can accelerate the research and applications of bacteriophages. However, some bacteriophages can escape from the cleavage of Cas protein, such as Cas9, and decrease the efficiency of genome editing. This study focuses on the bacteriophage T7, which is widely utilized but whose mechanism of evading the cleavage of CRISPR/Cas9 has not been elucidated. First, we test the escape rates of T7 phage at different cleavage sites, ranging from 10-2 to 10-5. The sequencing results show that DNA point mutations and microhomology-mediated end joining (MMEJ) at the target sites are the main causes. Next, we indicate the existence of the hotspot DNA region of MMEJ and successfully reduce MMEJ events by designing targeted sites that bypass the hotspot DNA region. Moreover, we also knock out the ATP-dependent DNA ligase 1.3 gene, which may be involved in the MMEJ event, and the frequency of MMEJ at 4.3 is reduced from 83% to 18%. Finally, the genome editing efficiency in T7 Δ1.3 increases from 20% to 100%. This study reveals the mechanism of T7 phage evasion from the cleavage of CRISPR/Cas9 and demonstrates that the special design of editing sites or the deletion of key gene 1.3 can reduce MMEJ events and enhance gene editing efficiency. These findings will contribute to advancing CRISPR/Cas-based tools for efficient genome editing in phages and provide a theoretical foundation for the broader application of phages.

Objective To explore the relationship between peripheral blood T lymphocyte subsets and prognosis of patients with advanced non-small cell lung cancer (NSCLC) who received treatment with camrelizumab. Methods We retrospectively collected data from 88 patients with advanced NSCLC who underwent camrelizumab treatment. Peripheral blood lymphocyte subsets were collected from patients before and two months after treatment. Kaplan-Meier curves and Cox regression analysis were employed to investigate the relationship between peripheral blood T lymphocyte subsets and PFS and OS. Results Compared with non-responder group, the baseline peripheral blood CD4+/CD8+ ratio was higher (P=0.038), while the CD8+T lymphocyte percentage was lower (P=0.036) in the responder group. Kaplan-Meier curves showed that a high baseline CD4+/CD8+ ratio was associated with long PFS and OS (P=0.001, P=0.023). Multivariate Cox analysis revealed that the baseline CD4+/CD8+ ratio was a significant predictor for PFS and OS. Additionally, a high post-treatment CD4+/CD8+ ratio and high CD4+T lymphocyte percentage were associated with long PFS (P=0.005, P=0.015), whereas a low post-treatment CD8+T lymphocyte percentage was associated with long PFS and OS (P=0.001, P=0.016). Conclusion The peripheral blood CD4+/CD8+ ratio can serve as a predictive factor for survival of patients with NSCLC treated with camrelizumab.

In response to the low recall rate of detection-based methods and the problem of missing target location information in density-based methods, which are the two mainstream dense-counting methods, a detection and counting method based on density map regression is proposed by combining the two tasks, achieving the counting and positioning of target objects in dense scenes. Complementing the advantages of two methods not only improves recall rate but also calibrates all targets. To extract richer feature information to deal with complex data scenarios, a feature pyramid optimization module is proposed, which vertically fuses low-level high-resolution features with top-level abstract semantic features and horizontally fuses same-size features to enrich the semantic expression of target objects. To address the issue of low pixel proportions occupied by target objects in dense counting scenarios, an attention mechanism for small targets is proposed to improve the network’s detection sensitivity, which can enhance the attention of the network to target objects by constructing a mask on the input image. Experimental results demonstrate that the proposed method significantly improves recall rate and accurately locates targets while maintaining accuracy, effectively providing counting and positioning information of input image, which has a wide range of application prospects in various fields such as industry and ecology.

ObjectiveTo understand the epidemiological characteristics and trends of sexually transmitted diseases （STDs） in Dehong Prefecture， Yunnan Province from 2010 to 2022， so as to provide a basis for the prevention and control of STDs in Dehong Prefecture.MethodsThe 2010‒2022 epidemic cards of STD cases in Dehong Prefecture were downloaded from the China Disease Control and Prevention Information System， and descriptive analysis of the incidence rate and demographic characteristics by disease type was conducted. The syphilis screening data of various populations in Dehong Prefecture between 2014 and 2022 were obtained from the National STD Control and Management Information System， and the syphilis positivity rates of key populations were calculated.ResultsA total of 18 225 STD cases were reported in Dehong Prefecture from 2010 to 2022， and the reported incidence rate increased from 17.1/105 in 2010 to 172.0/105 in 2022， showing an increasing trend （χ2trend=42.9， P

The quality of English language instruction in the classroom is a pivotal factor influencing students’ learning outcomes and performance in English. Grounded in this research context, this study draws upon relevant theoretical frameworks and examines a cohort of 80 students from the 2023 English class at Anhui Medical College. A multiple regression model was constructed using various dimensions of classroom instruction—namely, content, methodology, organization, teacher competence, instructional attitude, and linguistic features—as independent variables, with students’ English achievements serving as the dependent variable. Utilizing SPSS statistical software, both multiple regression and principal component analyses were employed to investigate the correlations between classroom teaching practices and student performance. The main conclusions of the article after the test are: in the rating of English teaching classroom performance, the teacher’s teaching ability (5.0952) scores high, and the teaching method (3.0324) scores the lowest, and the teacher’s teaching ability has a close relationship with the students’ English achievement. English achievement = 2.136 + 0.223*Teaching content + 0.41*Teaching style + 0.129*Classroom organization + 0.227*Teaching competence + 0.189*Teaching attitude + 0.449Language characteristics. There is a need to improve the performance related to classroom teaching and thus improve the performance of students.

Digitalization is a fundamentally disruptive force triggered by the fourth Industrial Revolution and the Internet of Things, driving technology upgrades, so what impact does digitalization have on the environment? In this paper, DAG-SVAR model was constructed to verify it. Through impulse response analysis, it was found that digitization drives technological upgrades, and environmental pollution is reduced through intelligent production, improved information environment, and ameliorated governance level. This paper suggests that, on the one hand, the technology upgrade is the key to digital empowerment in new fields and new spaces. Enterprises need to constantly explore diversified application scenarios, help the digital and intelligent transformation of energy, transportation, manufacturing and other industries, and greatly promote the integration and interaction of technology and various fields and sustainable development; on the other hand, it is necessary to strengthen digital ecological governance, promote the interconnection of everything, human-computer interaction, and the integration of space and land, so that information resources can fully flow, to create a digital green ecology.

This paper firstly constructs the matrix of eigenvalues of agricultural economy and ecological environment based on the original data, uses the entropy value method to judge the degree of dispersion of the indexes, determines the weights of the comprehensive evaluation index system of agricultural economy and ecological environment, and calculates the comprehensive scores of the agricultural economy and ecological environment system based on the weights of the indexes. Then, the synchronization development index model was used to express the coupled and coordinated development relationship between agroecology and agroeconomy. Finally, the regression analysis model was used to analyze the factors that affect the coupled and coordinated development of agroecology and agroeconomy. The level of agroecology in County A grew from 0.1 to 0.85, and the level of agroeconomy from 0.267 to 0.7. The value of agroeconomy and ecology coupling degree increased from 0.434 in 2010 to 0.683 in 2020, and it was gradually transformed from a dysfunction to a barely coupled one. This study deeply analyzes the influencing factors affecting the coupling and coordinated development of the agricultural economy and ecology, which is of great significance for promoting the high-quality development of the agricultural economy and maintaining ecological security.

Industrial software for digital design is a mainstay of industrial software and the foundation for intelligent manufacturing; however, a large gap exists between relevant domestic industries and the international frontier. Therefore, it is urgent to improve these software to support China’s manufacturing sector to enter the international advanced ranks. This study explores the significance of the industrial software for digital design, reviews the development status of industrial software in China and abroad, and analyzes the challenges faced by related industries in China. Key breakthrough directions are summarized, including seamless integration of structural computer-aided design/computer-aided engineering software and optimization software; design, analysis, and optimization integrated software driven by geometric features; simulation calculation and analysis featuring multi-body, multi-state, and multiphysical field coupling; cloudification and customization of industrial software; and heterogeneous parallel computing supported by algorithm strategies. Furthermore, we propose the following suggestions: (1) sorting out subdivided areas and formulating targeted industry support policies, (2) encouraging software enterprises to draw on each other’s strengths and formulating unified domestic standards, (3) providing targeted support for small- and medium-sized enterprises to expand their customer market, (4) mproving personnel training programs to gather high-end research staff, and (5) strengthening basic research and exploiting the advantages of domestic innovation market.

Patient recovery and well-being in healthcare settings can be influenced by various factors, including the stress induced by hospitalization and medical care. This study investigated the impact of indoor plants on patient recovery in dental clinics using state-of-the-art techniques to address the limited evidence supporting the claim that nature can alleviate stress and pain in hospitals. Thirty patients were randomly assigned to either a room with indoor plants or a control room without plants for a duration of 5 minutes after their treatment. Physiological responses were assessed using electroencephalography (EEG), heart rate variability, and skin conductance, whereas psychological responses were evaluated using the State-Trait Anxiety Inventory (STAI) and a visual analogue scale (VAS). The results revealed a significant increase in alpha wave power in the frontal region, indicating enhanced relaxation, as well as a significant increase in parasympathetic activity, suggesting improved autonomic balance. Furthermore, a significant decrease in skin conductance was observed when indoor plants were present compared with their absence, indicating reduced physiological arousal. Psychological assessments using the STAI demonstrated lower levels of stress and anxiety, whereas the VAS indicated reduced pain intensity among participants. Overall, these findings suggest that the presence of indoor plants contributes to patients’ relaxation and improved coping mechanisms during the recovery process. This study highlights the significance of incorporating indoor plants into healthcare settings to enhance patients’ overall well-being and promote positive recovery outcomes.

In ecologically fragile areas of western and northwestern China, where coal mine water is reused as domestic water or discharged into surface water systems after treatment (the discharge concentration of fluoride (F^-) is less than 1.0 mg/L). In order to solve the disadvantages of adsorption technology such as complicated process, difficult operation and management and unstable effluent quality, an experiment was carried out to remove fluoride by complexing-induction fluoride removal agent. The effects of dosage, reaction time, pH value and turbidity on fluoride removal were investigated, and the defluorination mechanism was analyzed. The results showed that the complexing-induction fluoride removal agent could capture ionic fluoride in mine water through the complex adsorption and chemical induction, and finally form blended precipitates to remove fluoride. When the dosage of the fluoride removal agent was 45 mg/L, reaction time was 12 min, pH value was 8~9 and the turbidity of raw water was less than 100 NTU, the concentration of fluoride ions in the simulateds mine water could be reduced from 5 mg/L to less than 1.0 mg/L. Carbonate ions affected fluoride removal significantly, followed by sulfate ions, while chloride ions had no obvious influence. In the continuous experiment of fluoride removal from mine water, the concentration of fluoride in the effluent was 0.75~0.90 mg/L, and the turbidity was 8.2~10.0 NTU.

In order to reduce the influence of wing box deformation on the spoiler control surface of an aircraft, a linkage mechanism was adopted for the suspension at both ends of the spoiler. During the stiffness characteristic test, it was found that the monitoring data of the spoiler structure showed a jumping trend which was not consistent with the conventional rudder surface test and the theoretical expectation. In order to solve this problem, the fish-bone method was used to analyze the experimental phenomenon. After the problem was located quickly and accurately, the structure were re-analyzed by the nonlinear analysis method of geometric large deformation based on Patran/Nastran platform. A numerical calculation curve which is in good agreement with the experimental phenomenon is obtained. The factors affecting the support stiffness and the solution to the problem of large deformation of the structure are discussed.The analysis method provides a solution for the dynamic problems of flexible mechanism, and the numerical results and the discussion have guiding and reference value for the design improvement. The cause localization analysis process of the test phenomenon can provide reference for other experiments.

In order to solve the problem of Bragg equation, a research on retrieval and feature of multimedia testing machine is proposed. Firstly, this paper investigates the various stages of multimedia retrieval system and some mainstream multimedia retrieval algorithms, in order to cover all aspects of relevant algorithms. Secondly, on the basis of investigation, eight representative algorithms are selected. These algorithms cover three stages of multimedia retrieval system, including feature extraction stage, feature matching stage and geometric verification stage. Based on the above observed characteristics, finally, some relevant suggestions on architecture design and system optimization are put forward, including the design of single node processor, the design in parallel environment and the suggestions for simulation and evaluation using this test set.

ObjectiveTo identify high-risk factors and high-risk process of nosocomial infection， and then take targeted prevention and control measures to improve nosocomial infection management.MethodsWe identified and determined the risk factors associated with nosocomial infection by using an expert brainstorming method， and then conducted risk assessment of the factors in the outcomes and process by using a semi-quantitative method.ResultsA total of 31 experts participated in the risk factor assessment. Risk assessment scores showed that nosocomial infection due to multi-drug resistant bacteria was the highest risk in the outcomes of nosocomial infection. Lack of isolation for airborne/droplet transmission， needle/sharp instrument injury， inadequate identification of infection risk and response measures in construction engineering， and insufficient implementation of infection control system were extremely high risk factors in the process of nosocomial infection.ConclusionPrevention and control should be strengthened on multi-drug resistant bacteria and catheter-related infections. The role of multidisciplinary team （MDT） in the prevention and control of nosocomial infection should be enhanced in medical practice. Risk assessment may facilitate the resource allocation and improve hand hygiene behavior.

ObjectiveA rapid method for determination of histamine and tyramine in milk was designed and studied by azo dye-spectroscopy.MethodsHistamine and tyramine in samples were extracted by hydrochloric acid solution， and dyed reaction was acted with azo reagent. Spectral method was used for detection within 10-15 min. External standard method was used for qualitative and quantitative analysis.ResultsThe limits of quantification of histamine and tyramine were both 10 mg/kg， which met the minimum limit requirement of 50 mg/kg specified in the current domestic and foreign standards for histamine. The recovery rate was about 90% and the relative standard deviation was about 10%. The results met the relevant requirements of food physical and chemical analysis.ConclusionThe detection method is fast， efficient， stable， reliable and cost saving. It is suitable for the rapid detection of histamine and tyramine in milk.

ObjectiveTo investigate the demographic characteristics， high-risk behavior and first CD4+T cell（CD4 cell） counts among newly reported HIV-infected Burmese in Dehong Dai Jingpo Autonomous Prefecture （Dehong Prefecture） from 2019 to 2020.MethodsA cross-sectional survey was conducted among newly reported HIV-infected Burmese cases in Dehong Prefecture from 2019 to 2020 to collect related information and measure their first CD4 cell counts.ResultsAmong 1 228 HIV-infected Burmese cases， 846 （68.9%） were males and 382 （31.1%） were females； 445 （36.2%） were from Kachin， and 210（17.1%） were from Shan. Of them， 960 cases （78.2%） had participated in the first CD4 cell counts testing， and 405 cases （42.2%） had a first CD4 cell counts

ObjectiveTo determine the characteristics and influencing factors of hepatitis C virus （HCV） co-infection among HIV concordant couples in Dehong Prefecture.MethodsUsing the data of newly reported HIV concordant couples in Dehong Prefecture from 2016 to 2019， we collected the demographic characteristics， exposure history， and HCV infection to determine the characteristics of HCV co-infection among HIV concordant couples.ResultsAmong the 160 HIV concordant couples included in the study， 46 （28.8%） males and 14 （8.8%） females were co-infected with HCV. The prevalence of HIV-HCV co-infection was higher among the male spouses who were diagnosed less than 40， Jingpo ethnic， Burmese， illiteracy， farmers， and intravenous drug users. In contrast， the prevalence of HIV-HCV co-infection was higher among the female spouses who were diagnosed less than 40， Jingpo ethnic， and Burmese. Logistic regression analysis among male spouses showed that the Jingpo ethnic and intravenous drug users had higher risk of HCV co-infection.ConclusionHIV concordant couples in Dehong Prefecture have high prevalence of HIV-HCV co-infection. Effective intervention strategies should be developed based on ethnic-specific factors and exposure characteristics among male and female spouses of HIV concordant couples.

With global warming, environmental degradation is becoming increasingly severe, and the impact on power transmission and transformation equipment is increasing. The changing environment will also have cross impacts, and people are paying more attention to environmental protection. Therefore, under complex environmental conditions, research on new technologies continues, and the emergence of new technologies can improve efficiency and reduce costs. This article focuses on three typical environments: noise environment, soft geological environment, and seismic environment, with a focus on analysing their latest technological situation and management strategies. At the same time, it proposes future development directions, guides the emergence of new business models and service methods, and promotes industry innovation and change.

This article aims to explore whether the visual style in AIGC art is constrained by certain factors that hinder the emergence of new styles and to analyze possible paths beyond this limitation. Methodologically, the article first deconstructs and subverts established visual rules in AIGC art from a post-structuralist perspective. Subsequently, it analyzes the limitations that AIGC art currently faces in innovation, namely, excessive reliance on imitating existing styles, from a perspective of technological philosophy. Finally, it proposes breakthroughs in style innovation for AIGC art through diversified training data, human-machine collaboration, and assimilating multicultural resources. The conclusion suggests that there is potential to surpass the 'visual maze' in AIGC art, but it requires progress in various aspects such as data, models, human-machine interaction to achieve this breakthrough. This will not only promote the development of AIGC art itself but also enrich the aesthetic experience of humanity.

Therapeutic radiopharmaceuticals combine radionuclides with carriers. It uses radionuclide suitable radiation energy and range in the tissue, selectively concentrated irradiation of diseased tissue, while avoiding damage to normal tissue and achieving the desired therapeutic effect. It is mainly used for cancer treatment or relief of tumor-related symptoms. It is widely used in tumor diagnosis and treatment, myocardial imaging, early detection of neurodegenerative diseases and imaging diagnosis of inflammatory tissues. In recent years, with the rapid development of targeted ligands and the wide application of new medical nuclides, radiotherapeutic drugs have attracted more and more attention. At present, nuclides such as 153Sm, 89Sr, 223Ra, 90Y, 131I and 177Lu are commonly used to treat cancer, bone metastasis, liver cancer and thyroid cancer, and show exciting potential in treatment. The research on radiotherapeutic drugs is also increasing rapidly. The clinical application and development status of radiopharma in the market and in the research stage are briefly introduced, in order to provide reference for the research and development of radiopharma in China.

With 90Y microspheres, radioactive microspheres are perfused to tumor feeding arteries through minimally invasive intervention, and then diffused and retained in small vessels of tumor terminals along with blood flow, so as to high selectively kill tumor cells by means of sustained release of high energy rays. 90Y microspheres are of important value in the local treatment of advanced liver cancer. At present, two types of 90Y microsphere products (SIR-Spheres- and TheraSpheres-) which have appeared on the market globally, have been clinically applied abroad for nearly twenty years, and have been incorporated into many authoritative norms and guidelines for the diagnosis and treatment of liver cancer. Since 2018, SIR-Spheres- and TheraSpheres- have gradually entered China and attracted the attention of domestic clinical experts, and have been incorporated into the latest relevant guidelines for the diagnosis and treatment of liver cancer in China. In 2022, SIR-Spheres-, as imported drugs, passed the approval of the National Medical Products Administration (NMPA) and were approved for listing to treat patients with surgically unresectable liver metastases of colorectal cancer after failure in standard treatment. At the same time, the first case of primary liver cancer has been treated by TheraSpheres-. 90Y carbon microspheres independently researched and developed in China show good clinical conversion potential. In order to more effectively carrying out clinical research and application of 90Y microsphere products in China and promote research and development innovation of similar products, this paper reviews types, the research and development status, clinical application and domestic development and outlook of 90Y microspheres, so as to provide reference for the research, development and application of 90Y microsphere drugs in China.

Operator acceleration libraries based on different hardware devices have become an indispensable part of deep learning framework,which can provide performance improvement for large-scale training or inference tasks dramatically.The current main-stream operator libraries are all developed based on GPU architecture,which is not compatible with other heterogeneous designs.SWDNN operator library is based on the development of SW26010 processor,which can not give full play to the performance of the upgraded SW26010 pro processor,nor can it meet the needs of the current large neural network models such as GPT-3 for large memory capacity and high memory access bandwidth.According to the architecture characteristics of SW26010 pro processor and the training requirements of large neural network model,a three-level parallel and neural network operator task sche-duling scheme based on multi-core group is proposed,which can satisfy the memory requirements of large model training and improve the overall computing performance and parallel efficiency.A memory access optimization method with triple asynchronous flow and overlap of computation and memory access is proposed,which significantly alleviates the memory access performance bottleneck of neural network operators.Based on the above methods,this paper constructs the SWTensor many-core group operator acceleration library based on the SW26010 pro processor.The experimental results of natural language processing model GPT-2 show that,computation-intensive operators and memory access intensive operators in SWTensor operator library reach the maxi-mum of 90.4% and 88.7% of the theoretical peak values respectively in single-precision floating-point computing performance and memory access bandwidth.

Chengdu and Chongqing, as two core cities in the Chengdu-Chongqing economic circle, have always been in the front rank of development and reform of urban-rural integration in China. But due to different basic conditions, ideas and priorities are different in the two cities. This paper establishes an analysis framework based on system theory, conducts a systematic comparison on the development and reform of urban-rural integration in the two cities to achieve a comprehensive comparison study and finds out that: (a) Owing to different basic conditions, Chengdu and Chongqing have adopted different reform ideas and measures. Chengdu places more emphasis on systematic advancement, while Chongqing attaches more importance to key breakthroughs. (b) Chengdu’s high level shows that in the practice of urban-rural integration, independent policies and measures in local areas have limited effects. System efficiency can surpass the sum of local areas’ efficiencies only if a systematic method is adopted to comprehensively promote policies and measures for institutional innovations in various fields.

As the most commonly used endocrine therapy regimen for patients with hormone receptor-positive (HR+) breast cancer (BC) at present, aromatase inhibitors (AIs) reduce the risk of localized and distant recurrence, contralateral BC and secondary cancer, and prolong disease-free survival. Clinical data show that poor adherence during AI treatment is mainly attributed to muscle and joint pain, fatigue, anxiety, depression and sleep disturbances during treatment. The rapid decline of estrogen caused by AIs in a short period of time enhances sympathetic activity, activates T cells in the body, produces inflammatory factors such as tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ) and interleukin (IL)-17A, and promotes the occurrence of inflammation and bone loss. This article reviewed the mechanism of poor dependence on AIs in BC patients from the neuro-immuno-endocrine (NIE) perspective and provided clues for clinical intervention against poor adherence.

BackgroundIn the injection and extraction Kicker power supply system of High Intensity Heavy-ion Accelerator Facility (HIAF), the transmission efficiency and stability of the control event directly affect the working performance of the power supply.PurposeThis study aims to develop the Kicker power supply communication system for precise control of hundreds of IGBT (insulated gate bipolar transistor) switches in the bipolar solid-state PFN-Marx generator of HIAF-Kicker power supply, hence to provide a gigabit readback path for the waveform data obtained by the high-speed acquisition system.MethodsBased on a digital controller with kernel Xilinx Kintex-7 FPGA (field programmable gate array) chip, the UDP (user datagram protocol) stack described by hardware language as the core of data communication was employed by the system. The scheme of intercepting waveform pulse and its front and back parts for transmission was adopted to improve the communication efficiency and save the system resources. The optical control signals required by the multi-channel power supply were provided by the controller via the connecting optical fiber daughter boards. The shielding case was added to reduce electromagnetic interference and enhance the stability of data transmission.ResultsThe data transmission test shows that the system meets the precise control demand of hundreds of IGBT switches, and the data transmit speed satisfies the needs of gigabit data readback.ConclusionsThe performance of designed system meets the communication requirements of Kicker power supply.

Objective To explore the role and mechanism of HMGB1 in the fatty acid metabolism reprogramming and mitochondrial fusion/fission of hypoxic and nutrient-poor pancreatic cancer cells. Methods The correlation between the expression level of HMGB1 in pancreatic cancer tissue and the survival rate of pancreatic cancer patients were analyzed by GEPIA database. CCK-8 assay was used to measure cell proliferation rate, and scratch test and Transwell chamber method were carried out to detect the effects of endogenous HMGB1 on the invasion and migration abilities of human pancreatic cancer cell line Patu8988 after hypoxic and nutrient-poor treatment. Laser confocal microscope was used to observe the changes of mitochondrial morphology of Patu8988 cells. Western blot was used to detect the expression levels of mitochondrial fusion/fission and de novo fatty acid synthesis-related proteins. Results GEPIA database analysis results showed that HMGB1 was highly expressed in pancreatic cancer tissues (P < 0.01), and the expression level was negatively correlated with the survival time of pancreatic cancer patients (P=0.00097). Knockdown of HMGB1 expression could inhibit the proliferation, invasion and migration abilities of Patu8988 cells under hypoxic and nutrient-poor conditions. However, mitochondrial fission in patu8988 cells was increased. Knockdown of HMGB1 in Patu8988 cells increased the expression of fission-related protein FIS1 while decreased the expression of p-DRP1(Ser637) and fusion-related protein MFN1 and MFN2 in hypoxic and nutrient-poor environment; ACLY, p-ACLY and FASN protein expression levels were down-regulated. Conclusion Endogenous HMGB1 can promote the fusion and inhibit the fission of mitochondria in hypoxic and nutrient-poor Patu8988 cells, maintain mitochondrial morphology and function, and thereby up-regulate ACLY protein expression and phosphorylation level, promote FA synthesis, and maintain the proliferation, invasion and migration abilities of pancreatic cancer cells.