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619 results on '"GALLI, CESARE"'

1. Unexpected impairment of INa underpins reentrant arrhythmias in a knock-in swine model of Timothy syndrome

Author

Porta-Sánchez, Andreu, Mazzanti, Andrea, Tarifa, Carmen, Kukavica, Deni, Trancuccio, Alessandro, Mohsin, Muhammad, Zanfrini, Elisa, Perota, Andrea, Duchi, Roberto, Hernandez-Lopez, Kevin, Jáuregui-Abularach, Miguel Eduardo, Pergola, Valerio, Fernandez, Eugenio, Bongianino, Rossana, Tavazzani, Elisa, Gambelli, Patrick, Memmi, Mirella, Scacchi, Simone, Pavarino, Luca F., Franzone, Piero Colli, Lentini, Giovanni, Filgueiras-Rama, David, Galli, Cesare, Santiago, Demetrio Julián, and Priori, Silvia G.

Published
2023
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5. Changes in glial cell activation and extracellular vesicles production precede the onset of disease symptoms in transgenic hSOD1G93A pigs

Author

Golia, Maria Teresa, Frigerio, Roberto, Pucci, Susanna, Sironi, Francesca, Margotta, Cassandra, Pasetto, Laura, Testori, Camilla, Berrone, Elena, Ingravalle, Francesco, Chiari, Marcella, Gori, Alessandro, Duchi, Roberto, Perota, Andrea, Bergamaschi, Luca, D’Angelo, Antonio, Cagnotti, Giulia, Galli, Cesare, Corona, Cristiano, Bonetto, Valentina, Bendotti, Caterina, Cretich, Marina, Colombo, Sara Francesca, and Verderio, Claudia

Published
2024
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6. The ethical assessment of Assisted Reproductive Technologies (ART) in wildlife conservation

Author

de Mori, Barbara, Mercugliano, Elena, Biasetti, Pierfrancesco, Pollastri, Ilaria, Spiriti, Maria Michela, Florio, Daniela, Andreucci, Francesco, Göritz, Frank, Holtze, Susanne, Galli, Cesare, Stejskal, Jan, Colleoni, Silvia, Lazzari, Giovanna, Seet, Steven, Zwilling, Jan, Ndeereh, David, Lekolool, Isaac, Ngulu, Stephen, Mijele, Dominic, Čižmár, Daniel, Simone, Raffaella, Schrade, Lisa, Basile, Simone, and Hildebrandt, Thomas B.

Published
2024
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9. Biomimetic Glyconanoparticle Vaccine for Cancer Immunotherapy

Author

Reuven, Eliran Moshe, Ben-Arye, Shani Leviatan, Yu, Hai, Duchi, Roberto, Perota, Andrea, Conchon, Sophie, Abramovitch, Shirley Bachar, Soulillou, Jean-Paul, Galli, Cesare, Chen, Xi, and Padler-Karavani, Vered

Subjects
Nutrition, Biotechnology, Immunization, Cancer, Vaccine Related, Prevention, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Good Health and Well Being, Adenocarcinoma, Animals, Biomimetic Materials, Cancer Vaccines, Colonic Neoplasms, Immunotherapy, Mice, Mice, Knockout, N-Acetylneuraminic Acid, Nanoparticles, Neuraminic Acids, Particle Size, Swine, neoantigen, cancer immunotherapy, biomimetic, glyconanoparticle, glycan microarray, sialic acid, N-glycolylneuraminic acid, Nanoscience & Nanotechnology
Abstract

Cancer immunotherapy aims to harness the immune system to combat malignant processes. Transformed cells harbor diverse modifications that lead to formation of neoantigens, including aberrantly expressed cell surface carbohydrates. Targeting tumor-associated carbohydrate antigens (TACA) hold great potential for cancer immunotherapy. N-glycolylneuraminic acid (Neu5Gc) is a dietary non-human immunogenic carbohydrate that accumulates on human cancer cells, thereby generating neoantigens. In mice, passive immunotherapy with anti-Neu5Gc antibodies inhibits growth of Neu5Gc-positive tumors. Here, we designed an active cancer vaccine immunotherapy strategy to target Neu5Gc-positive tumors. We generated biomimetic glyconanoparticles using engineered αGal knockout porcine red blood cells to form nanoghosts (NGs) that either express (NGpos) or lack expression (NGneg) of Neu5Gc-glycoconjugates in their natural context. We demonstrated that optimized immunization of "human-like" Neu5Gc-deficient Cmah-/- mice with NGpos glyconanoparticles induce a strong, diverse and persistent anti-Neu5Gc IgG immune response. The resulting anti-Neu5Gc IgG antibodies were also detected within Neu5Gc-positive tumors and inhibited tumor growth in vivo. Using detailed glycan microarray analysis, we further demonstrate that the kinetics and quality of the immune responses influence the efficacy of the vaccine. These findings reinforce the potential of TACA neoantigens and the dietary non-human sialic acid Neu5Gc, in particular, as immunotherapy targets.

Published
2019

10. Naïve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction

Author

Zywitza, Vera, Rusha, Ejona, Shaposhnikov, Dmitry, Ruiz-Orera, Jorge, Telugu, Narasimha, Rishko, Valentyna, Hayashi, Masafumi, Michel, Geert, Wittler, Lars, Stejskal, Jan, Holtze, Susanne, Göritz, Frank, Hermes, Robert, Wang, Jichang, Izsvák, Zsuzsanna, Colleoni, Silvia, Lazzari, Giovanna, Galli, Cesare, Hildebrandt, Thomas B., Hayashi, Katsuhiko, Diecke, Sebastian, and Drukker, Micha

Published
2022
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13. Laboratory Production of Equine Embryos

Author

Lazzari, Giovanna, Colleoni, Silvia, Crotti, Gabriella, Turini, Paola, Fiorini, Gaia, Barandalla, Maria, Landriscina, Lorenza, Dolci, Giovanni, Benedetti, Massimo, Duchi, Roberto, and Galli, Cesare

Published
2020
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16. In vitro fertilization (IVF) program in white rhinoceros

Author

Hildebrandt, Thomas Bernd, primary, Holtze, Susanne, additional, Colleoni, Silvia, additional, Hermes, Robert, additional, Stejskal, Jan, additional, Lekolool, Isaac, additional, Ndereeh, David, additional, Omondi, Patrick, additional, Kariuki, Linus, additional, Mijele, Domnic, additional, Mutisya, Samuel, additional, Ngulu, Stephen, additional, Diecke, Sebastian, additional, Hayashi, Katsuhiko, additional, Lazzari, Giovanna, additional, de Mori, Barbara, additional, Biasetti, Pierfrancesco, additional, Quaggio, Alessandra, additional, Galli, Cesare, additional, and Goeritz, Frank, additional

Published
2023
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18. Differential Immune Response to Bioprosthetic Heart Valve Tissues in the α1,3Galactosyltransferase-Knockout Mouse Model

Author

Casós, Kelly, primary, Llatjós, Roger, additional, Blasco-Lucas, Arnau, additional, Kuguel, Sebastián G., additional, Sbraga, Fabrizio, additional, Galli, Cesare, additional, Padler-Karavani, Vered, additional, Le Tourneau, Thierry, additional, Vadori, Marta, additional, Perota, Andrea, additional, Roussel, Jean-Christian, additional, Bottio, Tomaso, additional, Cozzi, Emanuele, additional, Soulillou, Jean-Paul, additional, Galiñanes, Manuel, additional, Máñez, Rafael, additional, and Costa, Cristina, additional

Published
2023
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20. In vitro fertilization program in white rhinoceros.

Author

Hildebrandt, Thomas Bernd, Holtze, Susanne, Colleoni, Silvia, Hermes, Robert, Stejskal, Jan, Lekolool, Isaac, Ndeereh, David, Omondi, Patrick, Kariuki, Linus, Mijele, Domnic, Mutisya, Samuel, Ngulu, Stephen, Diecke, Sebastian, Hayashi, Katsuhiko, Lazzari, Giovanna, de Mori, Barbara, Biasetti, Pierfrancesco, Quaggio, Alessandra, Galli, Cesare, and Goeritz, Frank

Subjects
WHITE rhinoceros, FERTILIZATION in vitro, FERTILITY preservation, ENDANGERED species, INDUCED ovulation, KEYSTONE species
Abstract

The Anthropocene is marked by a dramatic biodiversity decline, particularly affecting the family Rhinocerotidae. Three of five extant species are listed as Critically Endangered (Sumatran, Javan, black rhinoceros), one as Vulnerable (Indian rhinoceros), and only one white rhino (WR) subspecies, the Southern white rhinoceros (SWR), after more than a century of successful protection is currently classified as Near Threatened by the IUCN, while numbers again are declining. Conversely, in 2008, the SWR's northern counterpart and second WR subspecies, the Northern white rhinoceros (NWR), was declared extinct in the wild. Safeguarding these vanishing keystone species urgently requires new reproductive strategies. We here assess one such strategy, the novel in vitro fertilization program in SWR and - for the first-time NWR - regarding health effects, donor-related, and procedural factors. Over the past 8 years, we performed 65 procedures in 22 white rhinoceros females (20 SWR and 2 NWR) comprising hormonal ovarian stimulation, ovum pick-up (OPU), in vitro oocyte maturation, fertilization, embryo culture, and blastocyst cryopreservation, at an efficiency of 1.0 ± 1.3 blastocysts per OPU, generating 22 NWR, 19 SWR and 10 SWR/NWR hybrid blastocysts for the future generation of live offspring. [ABSTRACT FROM AUTHOR]

Published
2023
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21. In Vitro-Produced Equine Blastocysts Exhibit Greater Dispersal and Intermingling of Inner Cell Mass Cells than In Vivo Embryos

Author

Umair, Muhammad, Scheeren, Veronica Flores da Cunha, Beitsma, Mabel M, Colleoni, Silvia, Galli, Cesare, Lazzari, Giovanna, de Ruijter-Villani, Marta, Stout, Tom A E, Claes, Anthony, Voortplanting paard, and CS_Fertility

Subjects
blastocysts, in vitro embryo production, Inorganic Chemistry, cell lineage segregation, Organic Chemistry, Physical and Theoretical Chemistry, Molecular Biology, ICM, Spectroscopy, Catalysis, equine, Computer Science Applications
Abstract

In vitro production (IVP) of equine embryos is increasingly popular in clinical practice but suffers from higher incidences of early embryonic loss and monozygotic twin development than transfer of in vivo derived (IVD) embryos. Early embryo development is classically characterized by two cell fate decisions: (1) first, trophectoderm (TE) cells differentiate from inner cell mass (ICM); (2) second, the ICM segregates into epiblast (EPI) and primitive endoderm (PE). This study examined the influence of embryo type (IVD versus IVP), developmental stage or speed, and culture environment (in vitro versus in vivo) on the expression of the cell lineage markers, CDX-2 (TE), SOX-2 (EPI) and GATA-6 (PE). The numbers and distribution of cells expressing the three lineage markers were evaluated in day 7 IVD early blastocysts ( n = 3) and blastocysts ( n = 3), and in IVP embryos first identified as blastocysts after 7 (fast development, n = 5) or 9 (slow development, n = 9) days. Furthermore, day 7 IVP blastocysts were examined after additional culture for 2 days either in vitro ( n = 5) or in vivo (after transfer into recipient mares, n = 3). In IVD early blastocysts, SOX-2 positive cells were encircled by GATA-6 positive cells in the ICM, with SOX-2 co-expression in some presumed PE cells. In IVD blastocysts, SOX-2 expression was exclusive to the compacted presumptive EPI, while GATA-6 and CDX-2 expression were consistent with PE and TE specification, respectively. In IVP blastocysts, SOX-2 and GATA-6 positive cells were intermingled and relatively dispersed, and co-expression of SOX-2 or GATA-6 was evident in some CDX-2 positive TE cells. IVP blastocysts had lower TE and total cell numbers than IVD blastocysts and displayed larger mean inter-EPI cell distances; these features were more pronounced in slower-developing IVP blastocysts. Transferring IVP blastocysts into recipient mares led to the compaction of SOX-2 positive cells into a presumptive EPI, whereas extended in vitro culture did not. In conclusion, IVP equine embryos have a poorly compacted ICM with intermingled EPI and PE cells; features accentuated in slowly developing embryos but remedied by transfer to a recipient mare.

Published
2023

23. LIS1, a glyco-humanized swine polyclonal anti-lymphocyte globulin, as a novel induction treatment in solid organ transplantation

Author

Rousse, Juliette, primary, Royer, Pierre-Joseph, additional, Evanno, Gwénaëlle, additional, Lheriteau, Elsa, additional, Ciron, Carine, additional, Salama, Apolline, additional, Shneiker, Françoise, additional, Duchi, Roberto, additional, Perota, Andrea, additional, Galli, Cesare, additional, Cozzi, Emmanuele, additional, Blancho, Gilles, additional, Duvaux, Odile, additional, Brouard, Sophie, additional, Soulillou, Jean-Paul, additional, Bach, Jean-Marie, additional, and Vanhove, Bernard, additional

Published
2023
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24. Unexpected Impairment of INa current Underpins Reentrant Arrhythmias in a Knock-in Swine Model of Timothy Syndrome

Author

Porta-Sanchez, Andreu, primary, Mazzanti, Andrea, additional, Tarifa-Lora, Carmen, additional, Kukavica, Deni, additional, Trancuccio, Alessandro, additional, Mohsin, Muhammad, additional, Zanfrini, Elisa, additional, Perota, Andrea, additional, Duchi, Roberto, additional, Hernandez-Lopez, Kevin, additional, Fernandez-Moya, Eugenio, additional, Bongianino, Rossana, additional, Tavazzani, Elisa, additional, Scacchi, Simone, additional, Pavarino, Luca, additional, Franzone, Piero Colli, additional, Lentini, Giovanni, additional, Filgueiras-Rama, David, additional, Galli, Cesare, additional, Santiago, Demetrio, additional, and Priori, Silvia, additional

Published
2023
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25. In Vitro-Produced Equine Blastocysts Exhibit Greater Dispersal and Intermingling of Inner Cell Mass Cells than In Vivo Embryos

Author

Voortplanting paard, CS_Fertility, Fertility & Reproduction, Umair, Muhammad, Scheeren, Veronica Flores da Cunha, Beitsma, Mabel M, Colleoni, Silvia, Galli, Cesare, Lazzari, Giovanna, de Ruijter-Villani, Marta, Stout, Tom A E, Claes, Anthony, Voortplanting paard, CS_Fertility, Fertility & Reproduction, Umair, Muhammad, Scheeren, Veronica Flores da Cunha, Beitsma, Mabel M, Colleoni, Silvia, Galli, Cesare, Lazzari, Giovanna, de Ruijter-Villani, Marta, Stout, Tom A E, and Claes, Anthony

Published
2023

28. Robust induction of primordial germ cells of white rhinoceros on the brink of extinction

Author

Hayashi, Masafumi, primary, Zywitza, Vera, additional, Naitou, Yuki, additional, Hamazaki, Nobuhiko, additional, Goeritz, Frank, additional, Hermes, Robert, additional, Holtze, Susanne, additional, Lazzari, Giovanna, additional, Galli, Cesare, additional, Stejskal, Jan, additional, Diecke, Sebastian, additional, Hildebrandt, Thomas B., additional, and Hayashi, Katsuhiko, additional

Published
2022
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29. Application of decision tools to ethical analysis in biodiversity conservation

Author

Biasetti, Pierfrancesco, primary, Hildebrandt, Thomas B., additional, Göritz, Frank, additional, Hermes, Robert, additional, Holtze, Susanne, additional, Stejskal, Jan, additional, Galli, Cesare, additional, Pollastri, Ilaria, additional, Muzzo, Alessia, additional, Lekolool, Isaac, additional, Ndereeh, David, additional, Omondi, Patrick, additional, Kariuki, Linus, additional, Mijele, Domnic, additional, Mutisya, Samuel, additional, Ngulu, Stephen, additional, and de Mori, Barbara, additional

Published
2022
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34. Oxidative Stress in Structural Valve Deterioration: A Longitudinal Clinical Study

Author

Galiñanes, Manuel, Casós, Kelly, Blasco-Lucas, Arnau, Permanyer, Eduard, Máñez, Rafael, Le Tourneau, Thierry, Barquinero, Jordi, Schwartz, Simon, Bottio, Tomaso, Roussel, Jean Christian, Fellah-Hebia, Imen, Sénage, Thomas, Evangelista Masip, Arturo, Badano, Luigi P., Ruiz-Majoral, Alejandro, Galli, Cesare, Padler-Karavani, Vered, Soulillou, Jean-Paul, Vidal Guitart, Xavier, Cozzi, Emanuele, Costa, Cristina, Universitat Autònoma de Barcelona, Universitat Autònoma de Barcelona (UAB), Vall d'Hebron University Hospital [Barcelona], Vall d’Hebron Research Institute (VHIR), Llobregat Hospital [Barcelona], Quironsalud Teknon Heart Institute [Barcelona, Spain] (QTHI), Institut d'Investigació Biomèdica de Bellvitge [Barcelone] (IDIBELL), Bellvitge University Hospital [Barcelona, Spain], Centre d'investigation clinique (CIC) de Nantes -CIC Plurithématique (CIC 0004 - Nantes), Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Università degli Studi di Padova = University of Padua (Unipd), Azienda Ospedale Università di Padova = Hospital-University of Padua (AOUP), Centre hospitalier universitaire de Nantes (CHU Nantes), Institut du Thorax [Nantes], Università degli Studi di Milano-Bicocca = University of Milano-Bicocca (UNIMIB), Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Fondazione Avantea [Cremona, Italy], Tel Aviv University (TAU), Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology (U1064 Inserm - CR2TI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Institut Català de la Salut [Barcelona, Spain] (ICS), L’Hospitalet de Llobregat [Barcelona, Spain], The project was funded by the European Commission (FP7/2007–2013, Grant Agreement 603049: accessed on 1 September 2013, and PERIS SLT002/16/00445 funded by the Department of Health of the Generalitat de Catalunya, both granted to C.C., and cofunded by FEDER funds, a way to build Europe. IDIBELL benefits from the support of CERCA., European Project: 603049,EC:FP7:HEALTH,FP7-HEALTH-2013-INNOVATION-1,TRANSLINK(2013), Centre d’Investigation Clinique de Nantes (CIC Nantes), Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes), KERANDEL-DION, Céline, Defining the role of xeno-directed and autoimmune events in patients receiving animal-derived bioprosthetic heart valves - TRANSLINK - - EC:FP7:HEALTH2013-09-01 - 2017-08-31 - 603049 - VALID, Galinanes, M, Casos, K, Blasco-Lucas, A, Permanyer, E, Manez, R, Le Tourneau, T, Barquinero, J, Schwartz, S, Roussel, T, Fellah-Hebia, I, Senage, T, Evangelista, A, Badano, L, Ruiz-Majoral, A, Galli, C, Padler-Karavani, V, Soulillou, J, Vidal, X, Cozzi, E, and Costa, C

Subjects
Estrès oxidatiu, [SDV]Life Sciences [q-bio], Structural valve deterioration, Lipid peroxidation, Prosthesis Design, Biochemistry, structural valve deterioration, aortic valve, biological heart valves, lipid peroxidation, oxidative stress, protein nitration, transcatheter aortic valve implantation, Humans, Aortic valve, Molecular Biology, Heart valve prosthesis, Heart valves, oxidative stre, Transcatheter aortic valve implantation, Pròtesis valvulars cardíaques, MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Aortic Valve Stenosis, Vàlvules cardíaques, biological heart valve, Prosthesis Failure, [SDV] Life Sciences [q-bio], Treatment Outcome, Oxidative stress, Heart Valve Prosthesis, Biological heart valves, Protein nitration
Abstract

International audience; The cause of structural valve deterioration (SVD) is unclear. Therefore, we investigated oxidative stress markers in sera from patients with bioprosthetic heart valves (BHVs) and their association with SVD. Blood samples were taken from SVD (Phase A) and BHV patients during the first 24 (Phase B1) and >48 months (Phase B2) after BHV implantation to assess total antioxidant capacity (TAC), malondialdehyde (MDA), and nitrotyrosine (NT). The results show that MDA levels increased significantly 1 month after surgery in all groups but were higher at 6 months only in incipient SVD patients. NT levels increased gradually for the first 24 months after implantation in the BHV group. Patients with transcatheter aortic valve implantation (TAVI) showed even higher levels of stress markers. After >48 months, MDA and NT continued to increase in BHV patients with a further elevation after 60–72 months; however, these levels were significantly lower in the incipient and established SVD groups. In conclusion, oxidative stress may play a significant role in SVD, increasing early after BHV implantation, especially in TAVI cases, and also after 48 months’ follow-up, but decreasing when SVD develops. Oxidative stress potentially represents a target of therapeutic intervention and a biomarker of BHV dysfunction.

Published
2022
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35. LIS1, a glyco-humanized swine polyclonal anti-lymphocyte globulin, as a novel induction treatment in solid organ transplantation

Author

Rousse, Juliette, primary, Royer, Pierre-Joseph, additional, Evanno, Gwenaëlle, additional, Lheriteau, Elsa, additional, Ciron, Carine, additional, Salama, Apolline, additional, Shneiker, Françoise, additional, Duchi, Roberto, additional, Perota, Andrea, additional, Galli, Cesare, additional, Cozzi, Emmanuele, additional, Blancho, Gilles, additional, Duvaux, Odile, additional, Brouard, Sophie, additional, Soulillou, Jean-Paul, additional, Bach, Jean-Marie, additional, and Vanhove, Bernard, additional

Published
2022
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38. Induced pluripotent stem cells and cerebral organoids from the critically endangered Sumatran rhinoceros

Author

Zywitza, Vera, primary, Frahm, Silke, additional, Krüger, Norman, additional, Weise, Anja, additional, Göritz, Frank, additional, Hermes, Robert, additional, Holtze, Susanne, additional, Colleoni, Silvia, additional, Galli, Cesare, additional, Drukker, Micha, additional, Hildebrandt, Thomas B., additional, and Diecke, Sebastian, additional

Published
2022
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39. Ethical Analysis of the Application of Assisted Reproduction Technologies in Biodiversity Conservation and the Case of White Rhinoceros (Ceratotherium simum) Ovum Pick-Up Procedures

Author

Biasetti, Pierfrancesco, primary, Hildebrandt, Thomas B., additional, Göritz, Frank, additional, Hermes, Robert, additional, Holtze, Susanne, additional, Galli, Cesare, additional, Lazzari, Giovanna, additional, Colleoni, Silvia, additional, Pollastri, Ilaria, additional, Spiriti, Maria Michela, additional, Stejskal, Jan, additional, Seet, Steven, additional, Zwilling, Jan, additional, Ngulu, Stephen, additional, Mutisya, Samuel, additional, Kariuki, Linus, additional, Lokolool, Isaac, additional, Omondo, Patrick, additional, Ndeereh, David, additional, and de Mori, Barbara, additional

Published
2022
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42. Application of decision tools to ethical analysis in biodiversity conservation.

Author

Biasetti, Pierfrancesco, Hildebrandt, Thomas B., Göritz, Frank, Hermes, Robert, Holtze, Susanne, Stejskal, Jan, Galli, Cesare, Pollastri, Ilaria, Muzzo, Alessia, Lekolool, Isaac, Ndereeh, David, Omondi, Patrick, Kariuki, Linus, Mijele, Domnic, Mutisya, Samuel, Ngulu, Stephen, and de Mori, Barbara

Subjects
ETHICAL decision making, WHITE rhinoceros, DECISION trees, ANIMAL welfare, CUBES
Abstract

Copyright of Conservation Biology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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44. The ART of bringing extinction to a freeze e History and future of species conservation, exemplified by rhinos

Author

Hildebrandt, Thomas B., Hermes, Robert, Goeritz, Frank, Appeltant, Ruth, Colleoni, Silvia, de Mori, Barbara, Diecke, Sebastian, Drukker, Micha, Galli, Cesare, Hayashi Katzuiko, Lazzari, Giovanna, Loi, Pasqualino, Payne, J, Renfree, Marilyn, Seet, Steven, Stejskal, Jan, Swegen, A, Williams, Suzannah A., Zainuddin, Zainal Zahari, and Holtze, Susanne

Abstract

The ongoing mass extinction of animal species at an unprecedented rate is largely caused by human activities. Progressive habitat destruction and fragmentation is resulting in accelerated loss of biodiversity on a global scale. Over decades, captive breeding programs of non-domestic species were characterized by efforts to optimize species-specific husbandry, to increase studbook-based animal exchange, and to improve enclosure designs. To counter the ongoing dramatic loss of biodiversity, new approaches are warranted. Recently, new ideas, particularly the application of assisted reproduction technologies (ART), have been incorporated into classical zoo breeding programs. These technologies include semen and oocyte collection, artificial insemination, and in-vitro embryo generation. More futuristic ideas of advanced ART (aART) implement recent advances in biotechnology and stem-cell related approaches such as cloning, inner cell mass transfer (ICM), and the stem-cell-associated techniques (SCAT) for the generation of gametes and ultimately embryos of highly endangered species, such as the northern white rhinoceros (Ceratotherium simum cottoni) of which only two female individuals are left. Both, ART and aART greatly depend on and benefit from the rapidly evolving cryopreservation techniques and biobanking not only of genetic, but also of viable cellular materials suitable for the generation of induced pluripotent stem cells (iPSC). The availability of cryopreserved materials bridges gaps in time and space, thereby optimizing the available genetic variability and enhancing the chance to restore viable populations.

Published
2021
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45. The role of antibody responses against glycans in bioprosthetic heart valve calcification and deterioration

Author

Thomas Senage, Anu Paul, Thierry Le Tourneau, Imen Fellah-Hebia, Marta Vadori, Salam Bashir, Manuel Galiñanes, Tomaso Bottio, Gino Gerosa, Arturo Evangelista, Luigi P. Badano, Alberto Nassi, Cristina Costa, Galli Cesare, Rizwan A. Manji, Caroline Cueff de Monchy, Nicolas Piriou, Romain Capoulade, Jean-Michel Serfaty, Guillaume Guimbretière, Etienne Dantan, Alejandro Ruiz-Majoral, Guénola Coste du Fou, Shani Leviatan Ben-Arye, Liana Govani, Sharon Yehuda, Shirley Bachar Abramovitch, Ron Amon, Eliran Moshe Reuven, Yafit Atiya-Nasagi, Hai Yu, Laura Iop, Kelly Casós, Sebastián G. Kuguel, Arnau Blasco-Lucas, Eduard Permanyer, Fabrizio Sbraga, Roger Llatjós, Gabriel Moreno-Gonzalez, Melchor Sánchez-Martínez, Michael E. Breimer, Jan Holgersson, Susann Teneberg, Marta Pascual-Gilabert, Alfons Nonell-Canals, Yasuhiro Takeuchi, Xi Chen, Rafael Mañez, Jean-Christian Roussel, Jean-Paul Soulillou, Emanuele Cozzi, Vered Padler-Karavani, unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), MethodS in Patients-centered outcomes and HEalth ResEarch (SPHERE), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR des Sciences Pharmaceutiques et Biologiques (Nantes Université - UFR Pharmacie), Tel Aviv University (TAU), Brigham & Women’s Hospital [Boston] (BWH), Harvard Medical School [Boston] (HMS), Università degli Studi di Padova = University of Padua (Unipd), Universitat Autònoma de Barcelona (UAB), Vall d'Hebron University Hospital [Barcelona], Università degli Studi di Milano-Bicocca = University of Milano-Bicocca (UNIMIB), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Llobregat Hospital [Barcelona], Fondazione Avantea [Cremona, Italy], St. Boniface Hospital Albrechtsen Research Centre [Winnipeg], Israel Institute for Biological Research (IIBR), University of California [Davis] (UC Davis), University of California (UC), Institut d'Investigació Biomèdica de Bellvitge [Barcelone] (IDIBELL), Quironsalud Teknon Heart Institute [Barcelona, Spain] (QTHI), Mind the Byte [Barcelona, Spain], Molomics [Barcelona, Spain], Sahlgrenska Academy at University of Gothenburg [Göteborg], Institut Universitari de Ciència i Tecnologia [Barcelona, Spain] ((Inkemia Group) IUCT), DevsHealth [Barcelona, Spain] (DH), University College of London [London] (UCL), Bellvitge University Hospital [Barcelona, Spain], Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology (U1064 Inserm - CR2TI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Dantan, Etienne, Senage, T, Paul, A, Le Tourneau, T, Fellah-Hebia, I, Vadori, M, Bashir, S, Galinanes, M, Bottio, T, Gerosa, G, Evangelista, A, Badano, L, Nassi, A, Costa, C, Cesare, G, Manji, R, Cueff de Monchy, C, Piriou, N, Capoulade, R, Serfaty, J, Guimbretiere, G, Dantan, E, Ruiz-Majoral, A, Coste du Fou, G, Leviatan Ben-Arye, S, Govani, L, Yehuda, S, Bachar Abramovitch, S, Amon, R, Reuven, E, Atiya-Nasagi, Y, Yu, H, Iop, L, Casos, K, Kuguel, S, Blasco-Lucas, A, Permanyer, E, Sbraga, F, Llatjos, R, Moreno-Gonzalez, G, Sanchez-Martinez, M, Breimer, M, Holgersson, J, Teneberg, S, Pascual-Gilabert, M, Nonell-Canals, A, Takeuchi, Y, Chen, X, Manez, R, Roussel, J, Soulillou, J, Cozzi, E, Padler-Karavani, V, Institut Català de la Salut, [Senage T] Institut du Thorax, Institut National de la Santé et de la Recherche Médicale UMR1087, University Hospital, Nantes, France. Institut National de la Santé et de la Recherche Médicale UMR 1246-SPHERE, Nantes University, Tours University, Nantes, France. [Paul A] Department of Cell Research and Immunology, Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel. Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA. [Le Tourneau T, Fellah-Hebia I] Institut du Thorax, Institut National de la Santé et de la Recherche Médicale UMR1087, University Hospital, Nantes, France. [Vadori M] Consortium for Research in Organ Transplantation, Ospedale Giustinianeo, Padova, Italy. [Bashir S] Department of Cell Research and Immunology, Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel. [Galiñanes M] Servei de Cirurgia Cardíaca, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Evangelista A] Servei de Cardiologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Casós K] Servei de Cirurgia Cardíaca, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Infectious Diseases and Transplantation Division, Institut d’Investigació Biomèdica de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain. Grup de Recerca en Malalties Cardiovasculars, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Blasco-Lucas A] Servei de Cirurgia Cardíaca, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Cardiac Surgery Department, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona, Spain. [Permanyer E] Servei de Cirurgia Cardíaca, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Department of Cardiac Surgery, Quironsalud Teknon Heart Institute, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
[SDV]Life Sciences [q-bio], Immunology, enfermedades cardiovasculares::enfermedades cardíacas [ENFERMEDADES], Cardiovascular, Medical and Health Sciences, General Biochemistry, Genetics and Molecular Biology, Mice, Polysaccharides, Animals, Humans, Prospective Studies, Polysaccharide, Bioprosthesi, Bioprosthesis, 5.3 Medical devices, Animal, Calcinosis, Galactose, Otros calificadores::Otros calificadores::/cirugía [Otros calificadores], MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, General Medicine, Aortic Valve Stenosis, Aortic Valve Stenosi, Other subheadings::Other subheadings::/surgery [Other subheadings], Vàlvula aòrtica - Cirurgia, [SDV] Life Sciences [q-bio], Cardiovascular Diseases::Heart Diseases [DISEASES], Prospective Studie, Heart Disease, Aortic Valve, Immunoglobulin G, Antibody Formation, Calcinosi, Development of treatments and therapeutic interventions, Immunoglobulines, Human
Abstract

Outcomes research; Risk factors Investigación de resultados; Factores de riesgo Recerca dels resultats; Factors de risc Bioprosthetic heart valves (BHVs) are commonly used to replace severely diseased heart valves but their susceptibility to structural valve degeneration (SVD) limits their use in young patients. We hypothesized that antibodies against immunogenic glycans present on BHVs, particularly antibodies against the xenoantigens galactose-α1,3-galactose (αGal) and N-glycolylneuraminic acid (Neu5Gc), could mediate their deterioration through calcification. We established a large longitudinal prospective international cohort of patients (n = 1668, 34 ± 43 months of follow-up (0.1–182); 4,998 blood samples) to investigate the hemodynamics and immune responses associated with BHVs up to 15 years after aortic valve replacement. Early signs of SVD appeared in

Published
2021

47. List of Contributors

Author

Alicea, Bradly, primary, Amano, Tomokazu, additional, Ambroggio, Jennifer, additional, Amarnath, Dasari, additional, Campbell, Keith H.S., additional, Surani, M. Azim, additional, Baeumer, Nicole, additional, Balbach, Sebastian T., additional, Bertolini, Marcelo, additional, Beyhan, Zeki, additional, Boiani, Michele, additional, Byrne, James A., additional, Callesen, Henrik, additional, Canovas, Sebastian, additional, Chavatte-Palmer, Pascale, additional, Chen, LiHow, additional, Choi, Inchul, additional, Cibelli, José B., additional, Colleoni, Silvia, additional, Crosetto, Nicola, additional, Dinnyes, Andras, additional, Drexler, Hannes C.A., additional, Duchi, Roberto, additional, Echelard, Yann, additional, Egli, Dieter, additional, Faber, David, additional, Fan, Jason, additional, First, Neal L., additional, Fissore, Rafael A., additional, Fuellen, Georg, additional, Fulka, Josef, additional, Galli, Cesare, additional, Gardner, David K., additional, Gavin, William, additional, Green, Ronald M., additional, Gurdon, J.B., additional, Hirano, Kunio, additional, Hoshino, Yoichiro, additional, Howard, Harlan, additional, Inoue, Kimiko, additional, Ishino, Fumitoshi, additional, Ito, Junya, additional, Jammes, Hélène, additional, Jones, Jeff, additional, Jones, Kathleen M., additional, Kent-First, Marijo, additional, Kato, Yoko, additional, Kishigami, Satoshi, additional, Ko, Minoru S.H., additional, Kohda, Takashi, additional, Lagutina, Irina, additional, Lane, Michelle, additional, Latham, Keith E., additional, Lazzari, Giovanna, additional, Lee, Byeong Chun, additional, Lee, Jiyoung, additional, Lee, Kiho, additional, Lee, Rita, additional, Loi, Pasqualino, additional, Malcuit, Christopher M., additional, Masiello, Nick, additional, Meade, Harry, additional, Meng, Qinggang, additional, Mitalipov, Shoukhrat, additional, Mizutani, Eiji, additional, Modlinski, Jacek, additional, Nguyen, Van Thuan, additional, Niemann, Heiner, additional, Ogura, Atsuo, additional, Page, Raymond L., additional, Paudel, Yogesh, additional, Paull, Daniel, additional, Pfeiffer, Martin J., additional, Piedrahita, Jorge A., additional, Pinmee, Boonya, additional, Polgar, Zsuzsanna, additional, Pommer, Jerry, additional, Prather, Randall S., additional, Pruett-Miller, Shondra M., additional, Ptak, Grazyna, additional, Rudenko, Larisa, additional, Saeki, Kazuhiro, additional, Schatten, Gerald, additional, Schmidt, Mette, additional, Schofield, Michael, additional, Seidel, George E., additional, Siatkowski, Marcin, additional, Simerly, Calvin, additional, Siripattarapravat, Kannika, additional, St. John, Justin C., additional, Stice, Steven L., additional, Sullivan, Eddie J., additional, Tachibana, Masahito, additional, Tada, Takashi, additional, Tancos, Zsuzsanna, additional, Taniguchi, Shunji, additional, Teperek-Tkacz, Marta, additional, Tian, Xiuchun (Cindy), additional, Trounson, Alan, additional, Tso Sun, Liang, additional, Tsunoda, Yukio, additional, Wakai, Takuya, additional, Wakamatsu, Yuko, additional, Wakayama, Sayaka, additional, Wakayama, Teruhiko, additional, Wang, Zhongde, additional, Zhang, Xia, additional, and Zhu, Jie, additional

Published
2014
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48. Cloning of Equines

Author

Galli, Cesare, primary, Lagutina, Irina, additional, Duchi, Roberto, additional, Colleoni, Silvia, additional, and Lazzari, Giovanna, additional

Published
2014
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49. Improved efficiencies in the generation of multigene-modified pigs by recloning and using sows as the recipient

Author

Cho, Jongki, primary, Kim, Ghangyong, additional, Qamar, Ahmad Yar, additional, Fang, Xun, additional, Roy, Pantu Kumar, additional, Tanga, Bereket Molla, additional, Bang, Seonggyu, additional, Kim, Jong Keun, additional, Galli, Cesare, additional, Perota, Andrea, additional, Kim, Young Tae, additional, Che, Jeong-Hwan, additional, and Park, Chung-Gyu, additional

Published
2021
Full Text
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