Search

Your search keyword '"GABRIEL, Sylvie"' showing total 267 results
Start Over Author "GABRIEL, Sylvie"
267 results on '"GABRIEL, Sylvie"'

11. Comorbidities, healthcare resource utilization & treatment pattern among patients with prurigo nodularis, compared to a benchmark in Germany: A real- world evidence claims data study.

Author

Ständer, Sonja, Ketz, Miriam, Akumo, Divine, Kossack, Nils, Pignot, Marc, Chavda, Rajeev, and Gabriel, Sylvie

Subjects
PRURIGO, LENGTH of stay in hospitals, MEDICAL care, HEALTH insurance
Abstract

Background: Prurigo nodularis (PN) is a rare chronic inflammatory skin disease with a high disease burden, but data on clinical and economic burden are still scarce. Objective: To describe the real-world epidemiologic, clinical and therapeutic characteristics and related economic burden of patients with PN compared to a benchmark population in Germany. Methods: This retrospective study was based on an excerpt of German Statutory Health Insurance data of patients with an initial PN diagnosis between 2012 and 2016. PN cohort contained no record of PN in eight quarters before the index quarter and was followed up for eight quarters (unless deceased). Benchmark cohort without PN was calculated using direct standardization and 1:1 matching to PN cohort. Results: Out of 4,536,002 insured patients, 2309 incident patients with PN were identified and matched to the benchmark cohort out of 3,018,382 patients without PN. Patients were mostly between 45 and 80 years when diagnosed with PN. Higher comorbidity rates were reported for PN than benchmark, with a rising disease burden at follow-up. Most patients with PN (91.3%) were diagnosed outpatient and had >50% more outpatient visits than the benchmark cohort. Hospitalization rates were higher in PN (53.9%) versus benchmark (35.1%), yielding twice longer mean hospital stays for PN (12 days) compared to benchmark (6 days) (p < 0.001). The most common initial therapy for patients with PN was topical corticosteroids (47.6%); ≥10% of patients were treated with antidepressants, antihistamines or systemic corticosteroids. Therapy rates were higher for PN compared to benchmark (p < 0.001). Mean initial costs were twofold higher in PN versus benchmark for outpatient, inpatient and drugs. During follow-up, an increase of >70% in mean PN costs compared to benchmark was identified for outpatient, inpatient and concomitant treatments (p < 0.001). Conclusion: This study highlights the significantly higher clinical and economic burden incurred by PN compared to benchmark patients in Germany, reflecting the unmet medical need for PN. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

24. Association between prurigo nodularis and substance use disorders

Author

Taylor, Matthew T., primary, Bordeaux, Zachary A., additional, Deng, Junwen, additional, Parthasarathy, Varsha, additional, Adawi, Waleed, additional, Oladipo, Olusola O., additional, Alajmi, Ali, additional, Lee, Kevin K., additional, Marani, Melika, additional, Cornman, Hannah, additional, Kambala, Anusha, additional, Gabriel, Sylvie, additional, and Kwatra, Shawn G., additional

Published
2022
Full Text
View/download PDF

30. Association of Adult Atopic Dermatitis Severity With Decreased Physical Activity: A Cross-sectional Study.

Author

Schwartzman, Gabrielle, Lei, Donald, Ahmed, Adnan, Chavda, Rajeev, Gabriel, Sylvie, and Silverberg, Jonathan I.

Abstract

Background: Atopic dermatitis (AD) is associated with chronic pruritus, skin pain, sleep deprivation, depression, and anxiety, which may lead to decreased physical activity (PA). Objective: The aim of the study is to elucidate the impact of disease and itch severity on PA in adult AD. Methods: This is a prospective dermatology practice-based study of 955 AD patients (ages 18-97 years). Results: In multivariable logistic regression models controlling for age, sex, race/ethnicity, and asthma history, patient-reported global AD severity (PtGA), Patient-Oriented Eczema Measure, Eczema Area and Severity Index (EASI), and Investigator's Global Assessment (IGA) were associated with itch impairing light PA, moderate PA, and vigorous PA, as well as higher Patient-Reported Outcomes Measurement Information System Itch Questionnaire PA T-scores. Higher objective Scoring AD (O-SCORAD) was associated with itch impairing moderate PA. In bivariable analyses, performing greater than or equal to 30 minutes of light PA greater than or equal to 1 day a week was decreased with higher PtGA, Patient-Oriented Eczema Measure, and EASI; greater than or equal to 30 minutes of moderate PA greater than or equal to 1 day a week was decreased with PtGA, EASI, O-SCORAD, and IGA; and greater than equal to 30 minutes of vigorous PA was decreased with patient-reported AD severity, EASI, O-SCORAD, and IGA. In multivariable logistic regression models, the impact of itch on PA was inversely associated with light PA, moderate PA, and vigorous PA. Conclusion: Adult AD patients with more severe disease have decreased levels of PA secondary to itch. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

35. Health-related quality of life and economic burden of prurigo nodularis

Author

Whang, Katherine A., primary, Le, Thomas K., additional, Khanna, Raveena, additional, Williams, Kyle A., additional, Roh, Youkyung Sophie, additional, Sutaria, Nishadh, additional, Choi, Justin, additional, Gabriel, Sylvie, additional, Chavda, Rajeev, additional, Semenov, Yevgeniy, additional, and Kwatra, Shawn G., additional

Published
2022
Full Text
View/download PDF

46. Comparison of Patient-Oriented Eczema Measure and Patient-Oriented Scoring Atopic Dermatitis vs Eczema Area and Severity Index and other measures of atopic dermatitis

Author

Silverberg, Jonathan I, Lei, Donald, Yousaf, Muhammad, Janmohamed, Sherief R, Vakharia, Paras P, Chopra, Rishi, Chavda, Rajeev, Gabriel, Sylvie, Patel, Kevin R, Singam, Vivek, Kantor, Robert, Hsu, Derek Y, Dermatology, and Skin function and permeability

Subjects
Adult, Male, Adolescent, Dermatology, Middle Aged, Eczema/diagnosis, Patient reported outcome measures, Severity of Illness Index, Surveys and Questionnaires, Humans, young adult, Female, Dermatitis, Atopic/diagnosis, Aged
Abstract

BACKGROUND: Little is known about the measurement properties of Patient-Oriented Scoring Atopic Dermatitis (PO-SCORAD) in adults with atopic dermatitis (AD). Even less is known about how PO-SCORAD performs compared with the Patient-Oriented Eczema Measure (POEM). OBJECTIVE: To examine the measurement properties of PO-SCORAD and compare them with those of POEM. METHODS: A prospective dermatology practice-based study of 291 patients with AD (age range, 18-72 years). RESULTS: PO-SCORAD and POEM were moderately correlated with each other (Spearman ρ = 0.56) and had weak-moderate correlations with the Numeric Rating Scale (NRS) worst itch and average itch, Dermatology Life Quality Index (DLQI), ItchyQOL, Patient-Reported Outcomes Measurement Information System (PROMIS) Sleep Disturbance (SD) and Sleep-Related Impairment (SRI), Patient Health Questionnaire-9 (PHQ-9), and Eczema Area and Severity Index (EASI) (P < .001). POEM had significantly stronger correlations with DLQI, ItchyQOL, and EASI than did PO-SCORAD. PO-SCORAD and POEM had fair discriminant validity. Changes from baseline in PO-SCORAD and POEM were moderately correlated with each other; were weakly to strongly correlated with NRS worst itch and average itch, DLQI, ItchyQOL, PROMIS SD, PROMIS SRI, PHQ-9, and EASI; and had good test-retest reliability. There was no differential item functioning of items or floor or ceiling effects for PO-SCORAD or POEM. The thresholds for meaningful change for PO-SCORAD and POEM were -15.5 and -5.0, respectively. Median completion times for PO-SCORAD and POEM were 3 minutes and 1 minute, respectively. CONCLUSION: PO-SCORAD and POEM had good construct and cross-cultural validity, reliability, and responsiveness in adults with AD and were feasible for use in clinical trials and practice. However, POEM had better measurement properties than PO-SCORAD.

Published
2020

47. Long-term cost-effectiveness of early and sustained clopidogrel therapy for up to 1 year in patients undergoing percutaneous coronary intervention after presenting with acute coronary syndromes without ST-segment elevation

Author

Mahoney, Elizabeth M., Mehta, Shamir, Yuan, Yong, Jackson, Joseph, Chen, Roland, Gabriel, Sylvie, Lamy, Andre, Culler, Steven, Caro, Jaime, Yusuf, Salim, and Weintraub, William S.

Subjects
Cost benefit analysis -- Research, Coronary heart disease -- Drug therapy, Transluminal angioplasty -- Drug therapy, Transluminal angioplasty -- Patient outcomes, Cardiovascular agents -- Economic aspects, Cost benefit analysis, Health
Published
2006

49. Association of atopic dermatitis severity with cognitive function in adults

Author

Silverberg, Jonathan I., primary, Lei, Donald, additional, Yousaf, Muhammad, additional, Janmohamed, Sherief R., additional, Vakharia, Paras P., additional, Chopra, Rishi, additional, Chavda, Rajeev, additional, Gabriel, Sylvie, additional, Patel, Kevin R., additional, Singam, Vivek, additional, Kantor, Robert, additional, Hsu, Derek Y., additional, and Cella, David, additional

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results