1. About 8- and ∼84-h rhythms in endotheliocytes as in endothelin-1 and effect of trauma
- Author
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G. Cornélissen, G.S. Katinas, D.E Korzhevsky, Erwin M. Schaffer, F. Halberg, Douglas M. Hawkins, M.V Bueva, Nelson L. Rhodus, and L.R Sapozhnikova
- Subjects
medicine.medical_specialty ,Human blood ,Physiology ,Period (gene) ,education ,Anatomy ,Biology ,Biochemistry ,Endothelin 1 ,Cellular and Molecular Neuroscience ,Endocrinology ,medicine.anatomical_structure ,Rhythm ,Dermis ,Internal medicine ,medicine ,Circadian rhythm - Abstract
Population densities (PD) of capillaries (C) and endotheliocytes (E) were determined in pinnal dermis of C57BL mice before and after trauma. Moving (and overall) least-squares spectra before trauma detected in EPD (versus CPD) pronounced 3.5-day (circasemiseptan) and 8-h oscillations corresponding to components of the endothelin-1 chronome in human blood plasma reported earlier. Circadians were more pronounced in CPD. After trauma, circasemiseptan oscillations appeared also in CPD; their period gradually shortened and in two weeks split into about 2.5- and about 4.5-day oscillations; and circadian components became very pronounced. The pre-traumatic chronome was not restored within three weeks following trauma.
- Published
- 2001
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