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10 results on '"G.K. Surya Prakash"'

1. Copper-Catalyzed Synthesis of Difluoromethyl Alkynes from Terminal and Silyl Acetylenes

Author

Xanath Ispizua-Rodriguez, Vinayak Krishnamurti, Vanessa Carpio, Colby Barrett, and G.K. Surya Prakash

Subjects
Organic Chemistry
Abstract

An efficient method for the direct C(sp)-H difluoromethylation of terminal alkynes and the desilylation-difluoromethylation of (trimethylsilyl)acetylenes is disclosed. The copper-catalyzed transformation provides access to a wide range of structurally diverse CF

Published
2023
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6. List of contributors

Author

Colby Barrett, Allison A. Berger, Olga V. Boltalina, Darryl D. DesMarteau, Wojciech Grochala, Tadashi Honda, Russell P. Hughes, Xanath Ispizua-Rodriguez, Erhard Kemnitz, Beate Koksch, Marie Pierre Krafft, Thoralf Krahl, Florian Kraus, Vinayak Krishamurti, Jaroslav Kvíčala, Stefan Mahn, Moritz Malischewski, Johann Moschner, Iwao Ojima, Herbert W. Roesky, Gerd-Volker Röschenthaler, Konrad Seppelt, and G.K. Surya Prakash

Published
2021
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7. List of Contributors

Author

Steven Ackerman, Karelle Aiken, Nicholas D. Anastas, Paul T. Anastas, Gopalakrishnan Aridoss, Johannes Bader, Nadine Borduas, Christopher Brigham, Gabriela Bueno, Timothy P. Canty, Philip Coish, Kathryn E. Cole, John Collins, Amy Costa, Levente Cseri, Rupali Datta, Neil M. Donahue, Daniel P. Dowling, Timothy Dransfield, Clifford J. Ellstrom, Natalia Escobar-Pemberthy, Daniel M. Genest, Debanjana Ghosh, Gerald E. Gilligan, Alain Goeppert, Gerald Gourdin, Robyn E. Hannigan, Julie A. Himmelberger, William Horton, Patricia Hughes, Maria Ivanova, Stefan D. Kalev, Daniel Kirk-Davidoff, Anne Kokel, Kenneth K. Laali, Shainaz Landge, Nicholas A. Lee, Alexandra Maertens, Enda McGovern, Meaghan McKinnon, Manisha Mishra, Ken T. Ngo, James Noblet, George A. Olah, István Pálinkó, Peter Pogany, Helen C. Poynton, Deyang Qu, Mayamin Razali, William E. Robinson, Jonathan Rochford, Abhishek RoyChowdhury, Heather A. Rypkema, Ross J. Salawitch, Dibyendu Sarkar, Christian Schäfer, Laurel Schaider, Linda Schweitzer, Abid Shaikh, G.K. Surya Prakash, Gyorgy Szekely, Gurpal S. Toor, Béla Török, Marianna Török, David M. Wilmouth, and Julie B. Zimmerman

Published
2017
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8. 12/15-lipoxygenase inhibitors in diabetic nephropathy in the rat

Author

Nancy Kim, Jun Ma, Sharon G. Adler, Janine LaPage, Rama Natarajan, Breyon Clemmons, Cynthia C. Nast, Linda Lanting, Diana Becerra, Mihirbaran Mandal, and G.K. Surya Prakash

Subjects
Collagen Type IV, Male, medicine.medical_specialty, Benzylamines, Urinary system, Clinical Biochemistry, Kidney Glomerulus, Diabetic nephropathy, Excretion, Rats, Sprague-Dawley, chemistry.chemical_compound, Caffeic Acids, In vivo, Internal medicine, Diabetes mellitus, medicine, Albuminuria, Animals, Diabetic Nephropathies, 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid, Lipoxygenase Inhibitors, Creatinine, business.industry, Cell Biology, medicine.disease, Amides, Rats, Endocrinology, chemistry, medicine.symptom, business, Kidney disease
Abstract

The 12/15-lipoxygenase (12/15-LO) pathway is activated in diabetes mellitus (DM), increasing 12(S)-hydroxyeicosatetraenoic acid (12-HETE). We showed that a 12-LO inhibitor, cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate (CDC) inhibited 12/15-LO activity in vivo and assessed the efficacy of another 12/15-LO inhibitor, N-benzyl-N-hydroxy-5-phenylpentamidine (BHPP), to diminish urinary 12-HETE and ameliorate diabetic nephropathy (DN) over 4 months. Rats studied were control (C, n=8), DM (n=6), and rats injected with BHPP (C+BHPP, n=4) and (DM+BHPP, n=5). BHPP 3 mg/kg/day decreased urinary (U) 12-HETE/creatinine (cr) by 30-50% after one injection and after 1 week of daily injections in DM rats. U 12-HETE/cr excretion increased paradoxically in controls given BHPP. There was a highly significant relationship between U 12-HETE/cr excretion and U alb/cr (r=0.79, P

Published
2004

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