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We derive a self-consistent relation between turbulence spreading flux and vortex flow acceleration for time-stationary turbulence inside a magnetic island (MI) by extending the Charney-Drazin momentum theorem. The result, which consists of flux-surface-averaged expressions with geometrical weight, indicates a dominant balance between the turbulence spreading flux through regions around X-points and the vortex flow away from the X-points on the same flux surface. This is in qualitative agreement with experimental observations from DIII-D, KSTAR and HL-2A.

This conference report summarizes contributed papers and discussions presented at the 10th Asia-Pacific Transport Working Group (APTWG) held at Hanyang University, Seoul, South Korea from 13 to 16 June 2023. This year, technical working groups were organized under the following five topics: (A) isotope effects on the transport and physics of isotope mixture plasma, (B) turbulence spreading and coupling in the core-edge scrape-off layer, (C) interplay between MHD topology/instability and turbulent transport (covering the negative triangularity issue), (D) interactions between energetic-particle-driven instability and transport (focusing on cross-scale coupling physics), and (E) model reduction and experiments for validation. Summaries of significant progress from the presentations in the five technical working groups are given.

This paper reports global nonlinear gyrokinetic simulations that couple meso-scale reversed shear Alfvén eigenmodes (RSAEs) driven by energetic particles (EPs) and ion temperature gradient (ITG) microturbulence driven by thermal plasma, using equilibrium and profiles from DIII-D discharge #159243. In simulations focusing only on the ITG, electrostatic ITG drives a huge thermal ion heat transport, which is reduced by a factor of $10$ to a level close to the experimental value in electromagnetic simulation due to finite $\beta $ effect. In the simulations coupling the RSAE and ITG, ITG can scatter the resonant EP nonlinearly trapped by the RSAE and damp the zonal flows generated by the RSAE. The regulation of the RSAE by the ITG greatly reduces the initial saturation amplitude of the RSAE but increases the RSAE amplitude and associated EP transport to experimental levels in the quasi-steady state. The RSAE effects on the ITG, specifically the stronger zonal flows generated by the RSAE and the RSAE frequency modulation of the ITG-induced thermal ion heat transport, in turn, leads to a reduction of the thermal ion heat transport by more than a factor of $2$ . For a stronger background ITG, the regulation of the RSAE by the ITG is stronger, while the RSAE effects on the ITG are weaker. This work highlights the importance of cross-scale coupling in the dynamics of the AE turbulence and EP transport.

Further investigation of fast ion effects on turbulence and transport in the fast ion regulated enhancement (FIRE) mode discharge (Han et al 2022 Nature 609 269–275) was performed in this work as a continuation of a previous study (Kim et al 2023 Nucl. Fusion 63 124001) that showed that the dominant turbulence suppression mechanism by fast ions is the dilution effect in the FIRE mode discharge. The current study includes (i) the impact of the fast ion relevant mode observed in the simulation of thermal energy flux, (ii) dilution effects by fast ions compared to dilution effects by other species, and (iii) fast ion effects on electron-scale turbulence. First, nonlinear gyrokinetic simulation results show that turbulence is significantly suppressed even without the fast ion relevant mode, indicating that the impact of this mode on thermal transport is not significant in this discharge. Second, further analysis on the dilution effects shows the three following results: Turbulence is not completely suppressed by the reduced main ion density fraction effect due to impurities; the reduction in energy flux can be limited by a certain impurity mode that is destabilized by a high impurity density gradient from adjusting the main ion density gradient; electrons can contribute to turbulence suppression through the main ion density gradient change, although this effect is less significant compared to other species. Third, we observe that two fast ion effects can influence the linear growth rate of the electron-scale turbulence mode. The growth rate decreases by an increase in ${\beta _*}\left( { \equiv \left( { - 8\pi /{B^2}} \right){\text{d}}p/{\text{d}}r} \right)$ and increases by dilution effects, suggesting that fast ion effects on electron-scale turbulence can differ depending on the operation scenario, such as the fast ion fraction. The comprehensive analysis performed in this study can enhance our understanding of fast ion physics, required for burning plasma operation in the future.

This paper presents a mechanism for enhanced regulation of drift wave turbulence by zonal flows in the presence of a fast ion population. It demonstrates that dilution effects due to the energetic particles (EPs) have a far-reaching impact on all aspects of the nonlinear dynamics. The modulational growth of zonal flow shear and the corresponding evolution of drift wave energy are calculated with dilution effects. The coupled zonal flow growth and drift wave energy equations are reduced to a predator–prey model. This is solved for the fixed points, which represents the various states of the system. Results display a strong dependence on dilution, which leads to greatly reduced levels of saturated turbulence and transport. Implications for the FIRE mode plasma of KSTAR are discussed in detail. This model is perhaps the simplest dynamical one which captures the beneficial effects of EPs on confinement.

This letter provides a new physical insight into the fast ion effects on turbulence in plasmas having a high fast ion fraction and peaked fast ion density profile. We elucidate turbulence stabilization mechanisms by fast ions that result in internal transport barrier formation in the fast ion regulated enhancement mode plasma. Both linear and nonlinear gyrokinetic simulations show that the dominant turbulence suppression mechanisms are the dilution effects. In particular, we find that turbulence can be sufficiently suppressed solely by an inverted main ion density gradient due to fast ions, for the first time. New physical findings reported here improve our understanding of fast ion effects on turbulence, essential for fusion energy production where . Moreover, they will open up a new methodology to control plasma turbulence applicable to a wide range of plasma confinement regimes.

We present a gyrokinetic theory of self-generated E × B vortex flows in a magnetic island in a collisionless tokamak plasma with a background vortex flow. We find that the long-term evolution of the self-generated vortex flows can be classified into two regimes by the background vortex flow potential Φ, with an asymptotic criterion given by $e\Phi_\mathrm{cr}/T = \epsilon w/r$ , where T is temperature, ε is the inverse aspect ratio and r is the radial coordinate. We find that the background vortex flow above the criterion significantly weakens the toroidal precession-induced long-term damping and structure change of the self-generated vortex flows. That is, the finite background vortex flow is beneficial to maintain the self-generated vortex flows, favorable to an internal transport barrier formation. Our result indicates that the island boundary region is a prominent location for triggering the transition to an enhanced confinement state of the magnetic island.

In today's global context, challenges persist in preventing agri-food waste due to factors like limited consumer awareness and improper food-handling practices throughout the entire farm-to-fork continuum. Introducing a forward-thinking solution, the upcycling of renewable feedstock materials (i.e., agri-food waste and by-products) into value-added ingredients presents an opportunity for a more sustainable and circular food value chain. While multi-product cascade biorefining schemes show promise due to their greater techno-economic viability, several biotechnological hurdles remain to be overcome at many levels. This mini-review provides a succinct overview of the biotechnological and societal challenges requiring attention while highlighting valuable food-grade compounds derived from biotransformation processes. These bio-based ingredients include organic acids, phenolic compounds, bioactive peptides, and sugars and offer diverse applications as antioxidants, preservatives, flavorings, sweeteners, or prebiotics in foodstuffs and other consumer goods. Therefore, these upcycled products emerge as a sustainable alternative to certain potentially harmful artificial food additives that are still in use or have already been banned from the industry. [ABSTRACT FROM AUTHOR]

In this paper, an extendable fuzzy robust speed controller suitable for induction motor drive systems was proposed. Firstly, the two-degrees-of-freedom (2DOF) robust control technology with feedforward control and disturbance elimination method was adopted. Upon parameter variation and load disturbance, the motor drive system could utilize a robust controller to generate compensation signals and reduce the impact on the controlling performance of the motor drive system. The magnitude of the compensation signal was adjusted via the weighting factor. However, should a fixed weighting factor be adopted, system instability might be generated easily when time delay and saturation of control force occur. Based on the above, the smart method of extendable fuzzy theory (EFT) was adopted in this paper to adjust adequate weighting factors, where the controlling performance of the induction motor drive system could be improved accordingly. Lastly, the simulation software Matlab/Simulink (R2023b version) was applied to simulate the utilization of the controlling method proposed for the induction motor drive system. The simulation results proved that the extendable fuzzy robust speed controller proposed provided better speed tracking and load regulation-controlling performance than the conventional robust controller. [ABSTRACT FROM AUTHOR]

Plasma-functionalized liquids (PFLs) are rich in chemical species, such as ozone, hydrogen peroxide, singlet oxygen, hydroxyl radical and nitrogen oxides, commonly referred to as reactive oxygen and nitrogen species (RONS). Therefore, manifold applications are being investigated for their use in medicine, agriculture, and the environment. Depending on the goal, a suitable plasma source concept for the generation of PFLs has to be determined because the plasma generation setup determines the composition of reactive species. This study investigates three PFL-generating plasma sources—two spark discharges and a flow dielectric barrier discharge (DBD) system—for their efficacy in eliminating microbial contaminants from tissue samples aiming to replace antibiotics in the rinsing process. The final goal is to use these tissues as a cell source for cell-based meat production in bioreactors and thereby completely avoid antibiotics. Initially, a physicochemical characterization was conducted to better understand the decontamination capabilities of PFLs and their potential impact on tissue viability. The results indicate that the flow DBD system demonstrated the highest antimicrobial efficacy due to its elevated reactive species output and the possibility of direct treatment of tissues while tissue integrity remained. Achieving a balance between effective large-scale decontamination and the biocompatibility of PFLs remains a critical challenge. [ABSTRACT FROM AUTHOR]

Background/objectives: The connection between diet and migraine has gained increasing attention in migraine research due to its potential relevance as part of migraine treatment. This study reviewed the current evidence on the use of diets or specific foods in the prevention of migraine. Methods: A PubMed search was performed with the keywords "diet and migraine" OR "brain-gut-axis and migraine". One author (KVN) screened titles, abstracts, and full-text articles and excluded or included them based on eligibility criteria. Results: A ketogenic diet and a "Dietary Approaches to Stop Hypertension" diet reduced attack duration (p < 0.002), frequency (p < 0.05), and severity (p < 0.01). The ketogenic diet also reduced monthly medication intake (p ≤ 0.05). A low-fat vegan diet mixed with an elimination diet reduced the attack duration (p < 0.01), frequency (p < 0.05), severity (p < 0.0001), and percentage of medicated headaches (p < 0.001). Elimination diet reduced attack duration (p < 0.05), frequency (p < 0.02), severity (p < 0.01), and medication intake (p < 0.002). Elimination diet with IgG-positive foods reduced attack frequency (p < 0.001), and total medication intake (p < 0.01). Gluten-free diet reduced frequency (p = 0.02) and severity (p = 0.013). Conclusions: Certain diets and food items may trigger attacks in some migraine patients, though the overall evidence supporting this is limited. Modifying a diet may reduce symptoms such as attack duration, frequency, severity, and medication intake. However, the included studies' small populations and diverse study designs make the results difficult to apply in clinical practise. Further high-quality, double-blinded, randomised controlled trials are necessary to confirm the association between diet and migraine. [ABSTRACT FROM AUTHOR]

Artificial antireflective nanostructured surfaces, inspired by moth eyes, effectively reduce optical losses at interfaces, offering significant advantages in enhancing optical performance in various optoelectronic applications, including solar cells, light-emitting diodes, and cameras. However, their limited flexibility and low surface hardness constrain their broader use. In this study, we introduce a universal antireflective film by integrating nanostructures on both sides of a thin polycarbonate film. One side was thinly coated with Al2O3 for its high hardness, enhancing surface durability while maintaining flexibility. The opposite side was coated with SiO2 to optimize antireflective properties, making the film suitable for diverse environments (i.e., air, water, and adhesives). This dual-coating strategy resulted in a mechanically robust and flexible antireflective film with superior optical properties in various conditions. We demonstrated the universal capabilities of our antireflective film via optical simulations and experiments with the fabricated film in different environments. [ABSTRACT FROM AUTHOR]

Cs0.33WO3 (CWO) is a widely used inorganic material in window films and glass coatings, known for its excellent near-infrared radiation (NIR) blocking property and high visible light transmittance (Tvis). However, the stability of NIR blocking and the optical properties of CWO in the process of application is an urgent and important problem, because significant changes in optical results can impact the related products, such as window films, glass coatings, and so on. In this paper, the particle sizes and optical properties of CWO are tested to study the light stability and their relative relations. The results indicate that CWO particle sizes between 130 nm and 100 nm (D90, the point where 90% of the particles have a diameter smaller than the specified value) exhibit high stability in terms of NIR blocking and visible light transmittance (Tvis). CWO particles with D90 < 100 nm experience a greater reduction in NIR blocking, though this ability significantly recovers upon exposure to sunlight, making these coatings particularly suitable for use in tropical and subtropical climates. [ABSTRACT FROM AUTHOR]

Background: Early risk stratification is crucial due to septic patients' heterogeneity. Serum albumin level may reflect the severity of sepsis and host status. This study aimed to evaluate the prognostic ability of the initial sequential organ failure assessment (SOFA) score alone and combined with serum albumin levels for predicting 28-day mortality in patients with septic shock. Methods: We conducted an observational study using a prospective, multicenter registry of septic shock patients between October 2015 and May 2022 from 12 emergency departments in the Korean Shock Society and the results were validated by examining those from the septic shock cohort in Asan Medical Center. The primary outcome was 28-day mortality. The area under the receiver operating characteristic (ROC) curve was used to compare the predictive values of SOFA score alone and SOFA score combined with serum albumin level. Results: Among 5805 septic shock patients, 1529 (26.3%) died within 28 days. Mortality increased stepwise with decreasing serum albumin levels (13.6% in albumin ≥3.5, 20.7% in 3.5–3.0, 29.7% in 3.0–2.5, 44.0% in 2.5–2.0, 56.4% in <2.0). The albumin SOFA score was calculated by adding the initial SOFA score to the 4 points assigned for albumin levels. ROC analysis for predicting 28-day mortality showed that the area under the curve for the albumin SOFA score was 0.71 (95% CI 0.70–0.73), which was significantly higher than that of the initial SOFA score alone (0.68, 95% CI: 0.67–0.69). Conclusions: The combination of the initial SOFA score with albumin can improve prognostic accuracy for patients with septic shock, suggesting the albumin SOFA score may be used as an early mortality stratification tool. [ABSTRACT FROM AUTHOR]

Perennial ryegrass (Lolium perenne) is an underutilized lignocellulosic biomass that has several benefits such as high availability, renewability, and biomass yield. The grass press-juice obtained from the mechanical pretreatment can be used for the bio-based production of chemicals. Lactic acid is a platform chemical that has attracted consideration due to its broad area of applications. For this reason, the more sustainable production of lactic acid is expected to increase. In this work, lactic acid was produced using complex medium at the bench- and reactor scale, and the results were compared to those obtained using an optimized press-juice medium. Bench-scale fermentations were carried out in a pH-control system and lactic acid production reached approximately 21.84 ± 0.95 g/L in complex medium, and 26.61 ± 1.2 g/L in press-juice medium. In the bioreactor, the production yield was 0.91 ± 0.07 g/g, corresponding to a 1.4-fold increase with respect to the complex medium with fructose. As a comparison to the traditional ensiling process, the ensiling of whole grass fractions of different varieties harvested in summer and autumn was performed. Ensiling showed variations in lactic acid yields, with a yield up to 15.2% dry mass for the late-harvested samples, surpassing typical silage yields of 6–10% dry mass. [ABSTRACT FROM AUTHOR]

Vepdegestrant (formerly ARV-471), a novel proteolysis-targeting chimera (PROTAC), targets estrogen receptor alpha (ERα) for degradation, offering a promising option to treat advanced ER-positive breast cancer. We developed and validated a sensitive and rapid liquid chromatography–tandem mass spectrometry method to quantify vepdegestrant in rodent plasma using bavdegalutamide (formerly ARV-110) as an internal standard. Plasma samples were prepared with protein precipitation using acetonitrile and analyzed using reverse-phase C18 columns and a mobile phase of 10 mM ammonium formate in distilled water and acetonitrile. The method demonstrated linearity from 1 to 1000 ng/mL in mouse and rat plasma, meeting all validation criteria, and successfully applied to in vivo and in vitro studies. Pharmacokinetic analysis revealed low-to-moderate clearance (313.3, 1053 mL/h/kg) and oral bioavailability (17.91, 24.12%) of vepdegestrant in mice and rats, respectively. It was unstable in buffer solutions across pH 2–10 and in phosphate-buffered saline (pH 7.4), likely due to adsorption, but remained stable in mouse and rat plasma at varying temperatures. In liver microsomes, vepdegestrant exhibited moderate stability in rats but was stable in mice, dogs, and humans. These findings enhance the understanding of pharmacokinetic properties of vepdegestrant supporting further development of PROTAC drugs. [ABSTRACT FROM AUTHOR]

Strategically enriching the environment of zoo felids to encourage innate behaviors is essential to good welfare. To investigate how engagement differs among sensory-based enrichment, six items representing tactile (firehose log, Jolly Eggs), visual (mirror, movie), and olfactory (cinnamon, cologne) sensory categories were offered to three adult cheetah siblings. Each item was offered four times: twice during daytime hours and twice overnight (≥5 h/occasion). Static video monitoring was used to investigate engagement frequency and duration for each item and to observe grooming behaviors. Cheetahs engaged with visual enrichment more frequently (p < 0.05) and for greater (p < 0.05) periods than other items. Allogrooming occurred most frequently (p < 0.05) when the movie was provisioned at night. Tactile enrichment was only modestly engaged, with fewer but longer engagements (p < 0.05) at nighttime than at daytime. Autogrooming frequency did not vary among enrichment items but was greater (p < 0.05) at night than day. These findings showed that zoo cheetah responses to sensory enrichment items differed based on type and time of day. Visual stimuli were favored, whereas olfactory stimuli were generally ignored. This illustrates the benefit of diverse sensory-specific enrichment strategies. Such dynamic strategies can help overcome the challenge of individual preferences to encourage engagement reflective of the animal's natural behaviors. [ABSTRACT FROM AUTHOR]

Depression is a prevalent and debilitating mental disorder that affects millions worldwide. Current treatments, such as antidepressants targeting the serotonergic system, have limitations, including delayed onset of action and high rates of treatment resistance, necessitating novel therapeutic strategies. Ginsenoside Rc (G-Rc) has shown potential anti-inflammatory and neuroprotective effects, but its antidepressant properties remain unexplored. This study investigated the antidepressant effects of G-Rc in an L-alpha-aminoadipic acid (L-AAA)-induced mouse model of depression, which mimics the astrocytic pathology and neuroinflammation observed in major depressive disorder. Mice were administered G-Rc, vehicle, or imipramine orally after L-AAA injection into the prefrontal cortex. G-Rc significantly reduced the immobility time in forced swimming and tail suspension tests compared to vehicle treatment, with more pronounced effects than imipramine. It also attenuated the expression of pro-inflammatory cytokines (TNF-α, IL-6, TGF-β, lipocalin-2) and alleviated astrocytic degeneration, as indicated by increased GFAP and decreased IBA-1 levels. Additionally, G-Rc modulated apoptosis-related proteins, decreasing caspase-3 and increasing Bcl-2 levels compared to the L-AAA-treated group. These findings suggest that G-Rc exerts antidepressant effects by regulating neuroinflammation, astrocyte–microglia crosstalk, and apoptotic pathways in the prefrontal cortex, highlighting its potential as a novel therapeutic agent for depression. [ABSTRACT FROM AUTHOR]

Gliomas, the most common type of primary malignant brain tumors in adults, pose significant challenges in diagnosis and management due to their heterogeneity and potential aggressiveness. This review evaluates the utility of O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) positron emission tomography (PET), a promising imaging modality, to enhance the clinical management of gliomas. We reviewed 82 studies involving 4657 patients, focusing on the application of [18F]FET in several key areas: diagnosis, grading, identification of IDH status and presence of oligodendroglial component, guided resection or biopsy, detection of residual tumor, guided radiotherapy, detection of malignant transformation in low-grade glioma, differentiation of recurrence versus treatment-related changes and prognostic factors, and treatment response evaluation. Our findings confirm that [18F]FET helps delineate tumor tissue, improves diagnostic accuracy, and aids in therapeutic decision-making by providing crucial insights into tumor metabolism. This review underscores the need for standardized parameters and further multicentric studies to solidify the role of [18F]FET PET in routine clinical practice. By offering a comprehensive overview of current research and practical implications, this paper highlights the added value of [18F]FET PET in improving management of glioma patients from diagnosis to follow-up. [ABSTRACT FROM AUTHOR]

Background: Alcohol-related brain degeneration (ARBD) is associated with cognitive–motor impairments that can progress to disability and dementia. White matter (WM) is prominently targeted in ARBD due to chronic neurotoxic and degenerative effects on oligodendrocytes and myelin. Early detection and monitoring of WM pathology in ARBD could lead to therapeutic interventions. Objective: This study examines the potential utility of a non-invasive strategy for detecting WM ARBD using exosomes isolated from serum. Comparative analyses were made with paired tissue (Tx) and membrane vesicles (MVs) from the temporal lobe (TL). Methods: Long Evans rats were fed for 8 weeks with isocaloric liquid diets containing 37% or 0% caloric ethanol (n = 8/group). TL-Tx, TL-MVs, and serum exosomes (S-EVs) were used to examine ethanol's effects on oligodendrocyte glycoprotein, astrocyte, and oxidative stress markers. Results: Ethanol significantly decreased the TL-Tx expression of platelet-derived growth factor receptor alpha (PDGFRA), 2′,3′-cyclic nucleotide 3′ phosphodiesterase (CNPase), proteolipid protein (PLP), myelin oligodendrocyte glycoprotein (MOG), glial fibrillary acidic protein (GFAP), and 8-OHdG, whereas in the TL-MVs, ethanol increased CNPase, PDGFRA, and 8-OHdG, but decreased MOG and GFAP concordantly with TL-Tx. Ethanol modulated the S-EV expression by reducing PLP, nestin, GFAP, and 4-hydroxynonenal (HNE). Conclusion: Chronic ethanol exposures differentially alter the expression of oligodendrocyte/myelin, astrocyte, and oxidative stress markers in the brain, brain MVs, and S-EVs. However, directionally concordant effects across all three compartments were limited. Future studies should advance these efforts by characterizing the relationship between ABRD and molecular pathological changes in brain WM-specific exosomes in serum. [ABSTRACT FROM AUTHOR]

Penetrating deep into the cells of the human body in real time has become increasingly possible with the implementation of modern technologies in medicine. Atomic force microscopy (AFM) enables the effective live imaging of cellular and molecular structures of biological samples (such as cells surfaces, components of biological membranes, cell nuclei, actin networks, proteins, and DNA) and provides three-dimensional surface visualization (in X-, Y-, and Z-planes). Furthermore, the AFM technique enables the study of the mechanical, electrical, and magnetic properties of cells and cell organelles and the measurements of interaction forces between biomolecules. The technique has found wide application in cancer research. With the use of AFM, it is not only possible to differentiate between healthy and cancerous cells, but also to distinguish between the stages of cancerous conditions. For many years, AFM has been an important tool for the study of neurodegenerative diseases associated with the deposition of peptide amyloid plaques. In recent years, a significant amount of research has been conducted on the application of AFM in the evaluation of connective tissue cell mechanics. This review aims to provide the spectrum of the most important applications of the AFM technique in medicine to date. [ABSTRACT FROM AUTHOR]

Using the nonlinear 3D MHD code JOREK with reduced MHD equations (visco-resistive MHD), we have successfully simulated a recent n  =  2 resonant magnetic perturbation (RMP)-driven edge localized mode (ELM) suppression in KSTAR. We have found that such ELM suppression has been attributable not only to the degraded pedestal but also to the direct coupling between the peeling-ballooning mode (PBM) and RMP-driven plasma response. Notably, the pedestal pressure gradient is reduced as the radial transport is enhanced because of the formation of the stochastic layer and increased convection fluxes due to tearing and the kink-peeling mode driven by RMPs. The increased transport in the stochastic layer is due to the parallel transport across the stochastic fields, described by the Braginskii model in the simulation. While the linear stability of the PBM improves owing to the degraded pedestal, it is not a sole contributor to ELM suppression, in that the nonlinear mode coupling plays a more critical role. This outcome is consistent with previous studies where mode coupling affects the ELM mitigation or suppression. In addition, PBM locking has been numerically achieved during the ELM suppression phase, which may support the relationship between at the pedestal and the onset of ELM suppression. We suggest that PBM locking can enhance the mode interactions between RMPs and PBMs, which is significant for ELM suppression. [ABSTRACT FROM AUTHOR]

Aralia continentalis Kitag. (A. continentalis) holds significant medicinal value among the Aralia genus. It has traditionally been employed in ethnomedicine to address a wide range of conditions, including wind–cold–dampness arthralgia; rheumatic pain in the waist and lower extremities; lumbar muscular strain; injuries resulting from falls, fractures, contusions, and strains; headache; toothache; and abscesses. Modern pharmacological research has validated its therapeutic potential, encompassing anti-inflammatory, analgesic, antioxidant, antimicrobial, insecticidal, hepatoprotective, anti-diabetic, and cytotoxic properties, among other pharmacological effects. To compile comprehensive knowledge on A. continentalis, a rigorous literature search was undertaken utilizing databases like SciFinder, PubMed, and Web of Science. This review seeks to delve into the plant's traditional applications, geographical distribution, botanical characteristics, phytochemistry, and pharmacology. The objective is to lay a foundation and propose novel research directions for exploring the plant's potential applications. Currently, one hundred and fifty-nine compounds have been isolated and identified from A. continentalis, encompassing diterpenoids, steroids, triterpenoids, volatile components, phenolics, vitamins, trace elements, and other compounds. Notably, diterpenoids, steroids, triterpenoids, volatile components, and phenolics have exhibited pronounced pharmacological effects, such as anti-inflammatory, analgesic, antioxidant, hepatoprotective, antidiabetic, and antimicrobial activities. However, despite the extensive research conducted, further studies are imperative to unravel new components and mechanisms of action, necessitating more in-depth investigations. This comprehensive exploration could pave the way for advancing and harnessing the potential of A. continentalis. [ABSTRACT FROM AUTHOR]

This study proposes and simulates a smart system that can be used in production car seats to decrease whiplash risk in rear-end crashes. A sliding seat incorporating a semiactively controlled magnetorheological (MR) damper model positioned under the seat-pan is simulated with a validated biofidelic human body model. Since this is the first study that demonstrates a computer controlled anti-whiplash car seat system to the best of the authors' knowledge, a benchmark analysis is carried out to compare the proposed semiactive seat with a state-of-the-art passive anti-whiplash car seat using 23 different crash pulses, including the moderate and high severity crash pulses within the European New Car Assessment Program (EuroNCAP) whiplash risk assessment framework. The proposed semiactive design outperforms the passive seat design by further reducing the values of the critical EuroNCAP whiplash criteria, such as NIC and N k m , together with the loads acting on the upper neck. The semiactive seat lowers the upper-neck shear force by an amount of 4 kg and 7 kg while lessening the NIC by 10% and 21% and N k m by 9% and 56% for the EuroNCAP crash pulses, having a delta-V of 16 km/h and 24 km/h, respectively. The findings presented in this paper can aid in the design of car seats to further mitigate whiplash risk in rear-end crashes. [ABSTRACT FROM AUTHOR]

The reactivity of an electroencephalogram (EEG) to external stimuli is impaired in comatose patients showing burst-suppression (BS) patterns following hypoxic–ischemic brain injury (HIBI). We explored the reactivity of BS induced by isoflurane in rat models of HIBI and controls using intermittent photic stimulation (IPS) delivered to one eye. The relative time spent in suppression referred to as the suppression ratio (SR) was measured on the contralateral fronto-occipital cortical EEG channel. The BS reactivity (BSR) was defined as the decrease in the SR during IPS from the baseline before stimulation (SRPRE). We found that BSR increased with SRPRE. To standardize by anesthetic depth, we derived the BSR index (BSRi) as BSR divided by SRPRE. We found that the BSRi was decreased at 3 days after transient global cerebral ischemia in rats, which is a model of brain injury after cardiac arrest. The BSRi was also reduced 2 months after experimental perinatal asphyxia in rats, a model of birth asphyxia, which is a frequent neonatal complication in humans. Furthermore, Oxytocin attenuated BSRi impairment, consistent with a neuroprotective effect in this model. Our data suggest that the BSRi is a promising translational marker in HIBI which should be considered in future neuroprotection studies. [ABSTRACT FROM AUTHOR]

Breast metastasis originating from a primary lung tumor is exceedingly rare and can present challenges in distinguishing it from primary breast cancer. This case report discusses the management of a 64-year-old woman who initially presented with a nodule in her left breast. A biopsy revealed an infiltrating ductal carcinoma. Despite negative BRCA genetic testing, her significant family history of cancer and the presence of a newly detected right breast lesion led to a bilateral mastectomy. Post-operative imaging identified multiple hypodense nodules and a spiculated pulmonary nodule, necessitating further investigation. An endoscopic lung biopsy confirmed a primary pulmonary carcinoma with histological features similar to the breast carcinoma, suggesting the lung as the primary source. This case highlights the complexity of differentiating breast metastasis originating from a lung tumor and primary breast cancer. It underscores the importance of comprehensive diagnostic evaluations and the consideration of extramammary origins in metastatic cases. The findings emphasize the role of multidisciplinary teams in managing such rare and challenging cases and highlight the necessity for thorough and repeated assessments in atypical breast cancer presentations. [ABSTRACT FROM AUTHOR]

Fourier ptychographic microscopy (FPM) is a computational imaging technology that can acquire high-resolution large-area images for applications ranging from biology to microelectronics. In this study, we utilize multifocal plane imaging to enhance the existing FPM technology. Using an RGB light emitting diode (LED) array to illuminate the sample, raw images are captured using a color camera. Then, exploiting the basic optical principle of wavelength-dependent focal length variation, three focal plane images are extracted from the raw image through simple R, G, and B channel separation. Herein, a single aspherical lens with a numerical aperture (NA) of 0.15 was used as the objective lens, and the illumination NA used for FPM image reconstruction was 0.08. Therefore, simultaneous multifocal plane FPM with a synthetic NA of 0.23 was achieved. The multifocal imaging performance of the enhanced FPM system was then evaluated by inspecting a transparent organic light-emitting diode (OLED) sample. The FPM system was able to simultaneously inspect the individual OLED pixels as well as the surface of the encapsulating glass substrate by separating R, G, and B channel images from the raw image, which was taken in one shot. [ABSTRACT FROM AUTHOR]

Neurotransmitters are essential chemical messengers required for proper brain function, and any changes in their concentrations can lead to neuronal diseases. Therefore, sensitive and selective detection is crucial. This study presents a fast and simple colorimetric method for dopamine detection using three reagent solutions: AgNP and MPA, Ag/Au nanocomposite, and mercaptophenylacetic acid. TEM images showed a narrow distribution of Ag and Au nanoparticles with average sizes of 20 nm and 13 nm, respectively, with gold nanoparticles bound to the edges of silver nanoparticles. A paper-based biosensor was created using manual wax printing for the colorimetric detection of dopamine. Visual detection onsite showed color changes with both the silver nanoparticles and mercaptophenylacetic acid mixture and the silver–gold nanoparticle composite. Electrochemical detection using a glassy carbon electrode modified with 8 mM mercaptophenylacetic acid demonstrated high selectivity and sensitivity towards dopamine, with a peak in the range of 0.7–0.9 V. Interferences were minimized, ensuring high sensitivity and selective detection of dopamine. [ABSTRACT FROM AUTHOR]

The fungus Trichoderma is widely regarded as the most common fungal biocontrol agent for plant health management. More than 25 Trichoderma species have been extensively studied and have demonstrated significant potential in inhibiting not only phytopathogen growth but also insect pest infestations. In addition to their use as biopesticides, there is increasing evidence that several Trichoderma species can function as fungal endophytes by colonizing the tissues of specific plants. This colonization enhances a plant's growth and improves its tolerance to abiotic and biotic stresses. In recent decades, there has been a proliferation of literature on the role of Trichoderma endophytes in crop protection. Although the mechanisms underlying plant–fungal endophyte interactions are not yet fully understood, several studies have suggested their potential application in agriculture, particularly in the mitigation of plant pests and diseases. This review focuses on the diversity of Trichoderma endophytic strains and their potential use in controlling specific diseases and pests of crop plants. Trichoderma endophytes are considered a potential solution to reduce production costs and environmental impact by decreasing reliance on agrochemicals. [ABSTRACT FROM AUTHOR]

Astrocyte dysfunctions have been consistently observed in patients affected with depression and other psychiatric illnesses. Although over the years our understanding of these changes, their origin, and their consequences on behavior and neuronal function has deepened, many aspects of the role of astroglial dysfunction in major depressive disorder (MDD) and post-traumatic stress disorder (PTSD) remain unknown. In this review, we summarize the known astroglial dysfunctions associated with MDD and PTSD, highlight the impact of chronic stress on specific astroglial functions, and how astroglial dysfunctions are implicated in the expression of depressive- and anxiety-like behaviors, focusing on behavioral consequences of astroglial manipulation on emotion-related and fear-learning behaviors. We also offer a glance at potential astroglial functions that can be targeted for potential antidepressant treatment. [ABSTRACT FROM AUTHOR]

Osteoarthritis (OA) is a chronic degenerative joint disease that causes chronic pain, swelling, stiffness, disability, and significantly reduces the quality of life. Typically, OA is treated using painkillers and non-steroidal anti-inflammatory drugs (NSAIDs). While current pharmacologic treatments are common, their potential side effects have prompted exploration into functional dietary supplements. Recently, eggshell membrane (ESM) has emerged as a potential functional ingredient for joint and connective tissue disorders due to its clinical efficacy in relieving joint pain and stiffness. Despite promising clinical evidence, the effects of ESM on OA progression and its mechanism of action remain poorly understood. This study evaluated the efficacy of Ovomet®, a powdered natural ESM, against joint pain and disease progression in a monosodium iodoacetate (MIA)-induced rodent model of OA in mice and rats. The results demonstrate that ESM significantly alleviates joint pain and attenuates articular cartilage destruction in both mice and rats that received oral supplementation for 5 days prior to OA induction and for 28 days thereafter. Interestingly, ESM significantly inhibited mRNA expression levels of pro-inflammatory cytokines including tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6), as well as inflammatory mediators, cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase in the knee joint cartilage at the early stage of OA, within 7 days after OA induction. However, this effect was not observed in the late stage at 28 days after OA induction. ESM further attenuates the induction of protein expression for cartilage-degrading enzymes like matrix metalloproteinase (MMPs) 3 and 13, and a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5), in the late-stage. In addition, MIA-induced reduction of the protein expression levels of cartilage components, cartilage oligomeric matrix protein (COMP), aggrecan (ACAN) and collagen type II α-1 chain (COL2α1), and cartilage extracellular matrix (ECM) synthesis promoting transcriptional factor SRY-Box 9 (SOX-9) were increased via ESM treatment in the cartilage tissue. Our findings suggest that Ovomet®, a natural ESM powder, is a promising dietary functional ingredient that can alleviate pain, inflammatory response, and cartilage degradation associated with the progression of OA. [ABSTRACT FROM AUTHOR]