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2. The Vascular Impairment of Cognition Classification Consensus Study

Author

Olivia A. Skrobot, John O'Brien, Sandra Black, Christopher Chen, Charles DeCarli, Timo Erkinjuntti, Gary A. Ford, Rajesh N. Kalaria, Leonardo Pantoni, Florence Pasquier, Gustavo C. Roman, Anders Wallin, Perminder Sachdev, Ingmar Skoog, F.E. Taragano, J. Kril, M. Cavalieri, K.A. Jellinger, G.G. Kovacs, S. Engelborghs, C. Lafosse, P.H. Bertolucci, S. Brucki, P. Caramelli, T.C. Toledo Ferraz Alves, C. Bocti, T. Fulop, D.B. Hogan, G.R. Hsiung, A. Kirk, L. Leach, A. Robillard, D.J. Sahlas, Q. Guo, J. Tian, L. Hokkanen, H. Jokinen, S. Benisty, V. Deramecourt, J. Hauw, H. Lenoir, M. Tsatali, M. Tsolaki, U. Sundar, R.F. Coen, A.D. Korczyn, M. Altieri, M. Baldereschi, C. Caltagirone, G. Caravaglios, A. Di Carlo, V. DI Piero, G. Gainotti, S. Galluzzi, G. Logroscino, P. Mecocci, D.V. Moretti, A. Padovani, T. Fukui, M. Ihara, T. Mizuno, S.Y. Kim, R. Akinyemi, O. Baiyewu, A. Ogunniyi, A. Szczudlik, A.J. Bastos‐Leite, H. Firmino, J. Massano, A. Verdelho, L.S. Kruglov, M.K. Ikram, N. Kandiah, E. Arana, J. Barroso‐Ribal, T. Calatayud, A.J. Cruz‐Jentoft, S. López‐Pousa, P. Martinez‐Lage, M. Mataro, A. Börjesson‐Hanson, E. Englund, E.J. Laukka, C. Qiu, M. Viitanen, G.J. Biessels, F.‐E. Leeuw, T. Heijer, L.G. Exalto, L.J. Kappelle, N.D. Prins, E. Richard, B. Schmand, E. Berg, W.M. Flier, B. Bilgic, L.M. Allan, J. Archer, J. Attems, A. Bayer, D. Blackburn, C. Brayne, R. Bullock, P.J. Connelly, A. Farrant, M. Fish, K. Harkness, P.G. Ince, P. Langhorne, J. Mann, F.E. Matthews, P. Mayer, S.T. Pendlebury, R. Perneczky, R. Peters, D. Smithard, B.C. Stephan, J.E. Swartz, S. Todd, D.J. Werring, S.N. Wijayasiri, G. Wilcock, G. Zamboni, R. Au, S. Borson, A. Bozoki, J.N. Browndyke, M.M. Corrada, P.K. Crane, B.S. Diniz, L. Etcher, H. Fillit, S.M. Greenberg, L.T. Grinberg, S.W. Hurt, M. Lamar, M. Mielke, B.R. Ott, G. Perry, W.J. Powers, C. Ramos‐Estebanez, B. Reed, R.O. Roberts, J.R. Romero, A.J. Saykin, S. Seshadri, L. Silbert, Y. Stern, C. Zarow, Yoav Ben‐Shlomo, Anthony P. Passmore, Seth Love, Patrick G. Kehoe, Epidemiology, Neurology, Amsterdam Neuroscience - Neurodegeneration, APH - Personalized Medicine, APH - Methodology, Epidemiology and Data Science, Physics and medical technology, Clinicum, Neurologian yksikkö, University of Helsinki, Department of Neurosciences, HUS Neurocenter, O'Brien, John [0000-0002-0837-5080], and Apollo - University of Cambridge Repository

Subjects
0301 basic medicine, Standardization, Delphi Technique, Epidemiology, Delphi method, Vascular dementia, Delphi, 3124 Neurology and psychiatry, Terminology, 0302 clinical medicine, neurology (clinical), consensus, criteria, delphi, guidelines, vascular cognitive impairment, vascular dementia, cerebrovascular disorders, cognitive dysfunction, delphi technique, internet, epidemiology, health policy, developmental neuroscience, geriatrics and gerontology, cellular and molecular neuroscience, psychiatry and mental health, Conceptualization, Health Policy, Cognition, AUTOPSY, Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3], ALZHEIMERS-DISEASE, Settore MED/26 - NEUROLOGIA, Psychiatry and Mental health, Psychiatry and Mental Health, RELIABILITY, Vascular cognitive impairment, Psychology, CLINICAL-TRIALS, STROKE, Clinical psychology, Consensus, DISORDERS, DIAGNOSTIC-CRITERIA, Criteria, Guidelines, Developmental Neuroscience, Geriatrics and Gerontology, Neurology (clinical), Cellular and Molecular Neuroscience, Clinical Neurology, LESSONS, 03 medical and health sciences, medicine, Journal Article, Cognitive Dysfunction, VALIDITY, Health policy, Internet, 3112 Neurosciences, medicine.disease, Clinical trial, Cerebrovascular Disorders, 030104 developmental biology, MIXED DEMENTIA, 030217 neurology & neurosurgery
Abstract

H. Jokinen työryhmän jäsenenä. Introduction: Numerous diagnostic criteria have tried to tackle the variability in clinical manifestations and problematic diagnosis of vascular cognitive impairment (VCI) but none have been universally accepted. These criteria have not been readily comparable, impacting on clinical diagnosis rates and in turn prevalence estimates, research, and treatment. Methods: The Vascular Impairment of Cognition Classification Consensus Study (VICCCS) involved participants (81% academic researchers) from 27 countries in an online Delphi consensus study. Participants reviewed previously proposed concepts to develop new guidelines. Results: VICCCS had a mean of 122 (98-153) respondents across the study and a 67% threshold to represent consensus. VICCCS redefined VCI including classification of mild and major forms of VCI and subtypes. It proposes new standardized VCI-associated terminology and future research priorities to address gaps in current knowledge. Discussion: VICCCS proposes a consensus-based updated conceptualization of VCI intended to facilitate standardization in research. (C) 2016 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

Published
2017

3. Gerstmann–Sträussler–Scheinker Disease

Author

H. Budka, G.G. Kovacs, University of Zurich, Maloy, Stanley, and Hughes, Kelly

Subjects
1300 General Biochemistry, Genetics and Molecular Biology, 10208 Institute of Neuropathology, 570 Life sciences, biology, 610 Medicine & health, 1100 General Agricultural and Biological Sciences, 2700 General Medicine
Published
2013

4. S.02.02 Tauopathy causing frontotemporal lobe degeneration

Author

G.G. Kovacs

Subjects
Pharmacology, Pathology, medicine.medical_specialty, business.industry, Degeneration (medical), medicine.disease, Lobe, Psychiatry and Mental health, medicine.anatomical_structure, Neurology, medicine, Pharmacology (medical), Neurology (clinical), Tauopathy, business, Biological Psychiatry
Published
2010

7. Progress in the development of early diagnosis and a drug with unique pharmacology to improve cancer therapy.

Author

A. Lehotzky, N. Tőkési, I. Gonzalez-Alvarez, V. Merino, M. Bermejo, F. Orosz, P. Lau, G.G. Kovacs, and J. Ovádi

Subjects
CANCER treatment, CANCER hospitals, CANCER -- Eclectic treatment, ADJUVANT treatment of cancer
Abstract

Cancer continues to be one of the major health and socio-economic problems worldwide, despite considerable efforts to improve its early diagnosis and treatment. The identification of new constituents as biomarkers for early diagnosis of neoplastic cells and the discovery of new type of drugs with their mechanistic actions are crucial to improve cancer therapy. New drugs have entered the market, thanks to industrial and legislative efforts ensuring continuity of pharmaceutical development. New targets have been identified, but cancer therapy and the anti-cancer drug market still partly depend on anti-mitotic agents. The objective of this paper is to show the effects of KAR-2, a potent anti-mitotic compound, and TPPP/p25, a new unstructured protein, on the structural and functional characteristics of the microtubule system. Understanding the actions of these two potential effectors on the microtubule system could be the clue for early diagnosis and improvement of cancer therapy. [ABSTRACT FROM AUTHOR]

Published
2008
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