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Sm-doped YBa2Cu3O7–δ samples were prepared by conventional solid state reaction method in air. The studies of X-ray photoemission spectroscopy and X-ray absorption spectroscopy indicate that the extra electrons fill the holes in CuO2 planes, so that the hole carrier concentration decrease under Sm substitution. The X-ray absorption spectroscopy of Cu L-edge and O K-edge demonstrates that the hybridization strength between Cu 3 d and O 2 p decreases with increasing content of Sm, but the hybridization strength between Y 4 d, Ba 5 d, Sm 4 f and O 2 p increases with the increasing of Sm content, while the superconductivity of the Sm-doped YBa2Cu3O7–δ samples is suppressed, i.e., the superconducting transition temperature of the samples was lowered. Thus, our experimental results suggest a close relationship between the superconductivity and orbital hybridization.

A survey was conduct to analyze the usage situation of post-exposure prophylaxis(PEP) and related factors among men who have sex with men(MSM) in 6 cities of Shandong Province. Total of 2 620 subjects, the use ratio was 2.98% (78/2 620). Compared with age≤24 years,monthly income5 000 yuan,non-commercial sex, non-DU,non-STD,role for being insert in the anal intercourse,MSM was more likely to use PEP with age≥45 years(对山东省某6个地市招募的2 620名男男性行为者（MSM）进行调查，分析MSM人群HIV暴露后预防（PEP）的使用状况及相关影响因素。MSM人群整体PEP使用比例为2.98%（78/2 620），不同年龄、月收入水平、商业性行为发生状况、吸食新型毒品状况、性病患病状况、性行为角色的MSM人群其PEP使用比例差异具有统计学意义（

The goal of this paper is to investigate the use of Potentilla bifurca in the treatment of type 2 diabetes.We analyzed the improvement effect of 3T3-L1 adipocytes under insulin resistance (IR) with the compounds of Potentilla bifurca.The Potentilla bifurca can significantly improve the glycolipid metabolism disorder in 3T3-L1 adipocytes (the effect of MC compounds is very significant). It can improve insulin resistance by enhancing the glucose uptake of 3T3-L1 adipocytes, decreasing IL-6 content, and regulating the content of p-Akt/Akt, IKKβ, and p-NF-κBp65/NF-κBp65 in the IRS/PI3K/Akt signaling pathway.Studies have shown that Potentilla bifurca has the ability to regulate glucolipid metabolism and can be used in the treatment of type 2 diabetes.

The band structure in a kagome lattice can naturally exhibit flat band, Dirac cones, and van Hove singularity, enabling rich interplays between correlation and topology. However, the flat band is rarely detected just at the Fermi level in kagome materials, which would be crucial to realize emergent flat band physics. Here, combining angle-resolved photoemission spectroscopy, transport measurements and first-principles calculation, we observe a striking Fermi-level flat band in paramagnetic YCr6Ge6 as a typical signature of electronic kagome lattice. We explicitly unveil that orbital character plays an essential role to realize electronic kagome lattice in crystals with transition-metal kagome layers. We further engineer this material with magnetic rare earth elements to break the time-reversal symmetry of the Fermi-level kagome flat band. Our work establishes a Fermi-level flat band in a kagome magnet as an exciting quantum platform.

The incidence of anastomotic leakage, a common and serious postoperative complication of low rectal cancer, remains high. Clarifying the risk factors for anastomotic leakage in patients with low rectal cancer after surgery can help guide clinical treatment and help patients improve their prognosis. The current literature suggests that the risk factors affecting the occurrence of anastomotic leakage after low rectal cancer include three aspects: (1) individual factors: male gender, high body mass index, malnutrition, smoking, alcoholism, and metabolic diseases; (2) tumor factors: the lower margin of tumor5 cm from the anal verge, tumor diameter2.5 cm, late tumor stage, high level of tumor markers and preoperative intestinal obstruction; (3) surgical factors: long operative time (180 min), intraoperative bleeding (≥70 ml), more than 2 cartridges of stapling for anastomosis, contamination of the operative field, epidural analgesia and intraoperative hypothermia. Notably, the surgical approach (laparoscopic, open and hand-assisted laparoscopic surgery) was not a factor influencing the occurrence of postoperative anastomotic leakage in low rectal cancer. The findings on the effects of receiving neoadjuvant therapy, gut microbiota,intestinal bowel preparation, insufficient time for preoperative antibiotic prophylaxis, left colonic artery dissection, intraoperative blood transfusion, pelvic drainage, transanal drainage and combined organ resection, and postoperative diarrhea on postoperative anastomotic leakage in low rectal cancer are controversial. However, clinical workers can still take measures to reduce the risk of anastomotic leakage according to the above risk factors by making a good assessment before surgery, actively avoiding them during and after surgery, and taking measures for each step, so as to bring maximum benefits to patients.低位直肠癌术后常见和严重的并发症吻合口漏发生率居高不下，明确低位直肠癌患者术后发生吻合口漏高危因素，有助于指导临床治疗，帮助患者改善预后。目前的文献提示，影响低位直肠癌术后吻合口漏发生的风险因素包括3个方面：（1）个体因素：性别为男性、高体质指数、营养不良和不良嗜好与代谢性疾病；（2）肿瘤因素：肿瘤下缘距肛缘5 cm、肿瘤直径2.5 cm、肿瘤分期晚、肿瘤标志物水平高和术前发生肠梗阻；（3）手术因素：手术时间长（180 min）、术中出血量（≥70 ml）、吻合器激发2次以上、术野污染、硬膜外镇痛和术中低体温。值得注意的是，手术方式（腹腔镜、开腹和手辅助腹腔镜）并不是影响低位直肠癌术后吻合口漏发生的因素。而接受新辅助治疗、肠道菌群、肠道准备情况、术前抗生素预防时间不足、左结肠动脉离断、术中输血、盆腔引流、经肛引流和联合器官切除以及术后腹泻等对低位直肠癌术后吻合口漏的影响，相关研究结论还不太统一。但临床工作者仍可根据上述风险因素，在术前做好评估，术中及术后积极避免，针对每一环节采取措施，降低吻合口漏的发生风险，从而给患者带来最大获益。.

子宫内膜异位症（内异症）是育龄期妇女的常见疾病之一，常导致患者生殖功能及卵巢储备功能降低，因此，在内异症诊治中应注意保护患者的生育力，改善生殖功能。依据患者年龄、内异症病变范围、内异症生育指数、卵巢储备功能及患者意愿等因素综合制定治疗策略；术前做好评估，术后积极备孕或辅助生殖技术；对于无生育需求者，通过药物治疗改善症状，控制病情进展，做好长期管理。对于一些病情严重或复发的内异症患者，可在术前进行生育力保存。.

他汀类药物，是羟甲基戊二酰辅酶A（HMG-CoA）还原酶抑制剂，能够有效阻止甲羟戊酸合成途径降低胆固醇的合成，是重要的降脂药物，在心脑血管疾病的预防和治疗中有着十分重要的地位。他汀类药物相关性肌病（statins-associated muscle symptoms，SAMS）是他汀类药物主要的副作用，一部分患者甚至不得不因此终止他汀类药物治疗。本篇综述就SAMS的发病机制最新研究和干预措施展开讨论，为他汀类药物的合理使用和肌病相关的副作用的分子机制研究提供参考。.

Chronic and infectious wound healing has always been an issue of concern in clinical and scientific research, in which bacterial infection and oxidative damage are the key factors hindering wound healing. Carbon dots, as a new material, has attracted much attention because of its unique physical and chemical properties and good biological safety. In recent years, the researches on the antibacterial property, antioxidant, and photoluminescence properties of carbon dots are more and more extensive and carbon dots have great potential in the treatment of chronic and infectious wounds. This paper reviews the research progress of carbon dots in three aspects: antibacterial, anti-oxidation and monitoring of wound infection are reviewed, and further discusses its specific mechanism, potential research direction, and application prospect.慢性、感染性创面愈合一直是临床及科学研究方面引人关注的问题，其中细菌感染及氧化损伤是阻碍创面愈合的关键因素。碳点作为一种新型材料，由于其独特的物理化学性质及良好的生物安全性而备受关注。近年来，针对碳点抗菌性、抗氧化性、光致发光性的研究越来越广泛，碳点在慢性及感染性创面治疗中有巨大潜力。该文综述了碳点抗菌、抗氧化、监测创面感染状态3个方面的研究进展，并进一步探讨了其具体的作用机制、潜在研究方向及应用前景。.

This article analyzed the medical records of two patients with Vibrio vulnificus primary sepsis who were admitted to the First Affiliated Hospital of Naval Medical University and reviewed the latest literature. On November 6, 2019, a 54-year-old male patient was admitted to the hospital. The patient's lower limbs were red, swollen, and painful with ecchymosis and hemorrhagic bullae after he ate freshwater products. The emergency fasciotomy was performed 3 h after admission, and the multiple organ failure occurred after operation. The patient was given up treatment 24 h after admission. On August 12, 2020, a 73-year-old male patient was admitted to the hospital. He was in shock state on admission and had hemorrhagic bullae on his right lower limb after he ate seafood. At 3 h post admission, he underwent emergency surgical exploration and amputation of right thigh. Six days later, he received negative pressure wound treatment on the stump. On the 13本文对海军军医大学第一附属医院收治的2例创伤弧菌原发性脓毒症患者的临床资料进行总结分析，并综述最新文献。2019年11月6日收治1例54岁男性患者，其进食淡水水产品后双下肢红肿、疼痛明显，出现瘀斑及血性水疱，入院后3 h急诊行筋膜切开减张术，术后各脏器功能衰竭，入院后24 h放弃治疗。2020年8月12日收治1例73岁男性患者，其进食海鲜后右下肢出现血性水疱，入院时呈休克状态，入院后3 h急诊手术探查并行右大腿截肢，6 d后残端行负压伤口疗法，入院后13 d家属放弃积极治疗，入院后15 d患者死亡。2例患者均未能第一时间诊断，病情进展迅速，出现坏死性筋膜炎及多器官功能衰竭，明确诊断后分别予筋膜切开减张和高位截肢，微生物培养结果均为创伤弧菌。虽最终均未救治成功，但早期截肢患者病程及部分指标均优于切开减张者。创伤弧菌分布广泛，淡水水产品中多次检出，致病途径模糊复杂，极易误诊，宜建立创伤弧菌脓毒症救治流程，尽早积极手术干预，筋膜切开和清创应彻底，合并出血性大疱者应早期截肢，术后采用综合措施提高患者存活率。.

Ciprofol is a newly developed intravenous sedative-hypnotic drug. The objective of the study was to prove whether ciprofol was non-inferior to propofol for the successful induction of general anesthesia. The ideal post-induction sedation level was assessed by comparing patients' clinical symptoms and their hemodynamic effects in responding to noxious stimuli, mostly tracheal intubation and bispectral index (BIS) alterations following ciprofol/propofol administration.In this multi-center, randomized, double-blind phase 3 trial, selective surgery patients were randomly assigned in a 1:1 ratio to either ciprofol 0.4 mg/kg (n = 88) or propofol 2.0 mg/kg (n = 88) groups. The primary endpoint was the percentage of patients with successful anesthesia inductions. Secondary endpoints included the times to successful induction of general anesthesia and loss of the eyelash reflex, changes in BIS, as well as safety indicators.The anesthesia induction success rates for both ciprofol 0.4 mg/kg and propofol 2 mg/kg groups were 100.0%, with a 95% CI lower success limit of -4.18% difference between the two groups, indicating that ciprofol was non-inferior to propofol. For secondary outcomes, the average time to successful anesthesia and loss of the eyelash reflex were 0.91 min and 0.80 min for ciprofol and 0.80 min and 0.71 min for propofol, respectively. The pattern of BIS changes with ciprofol was similar to propofol and stable during the anesthesia maintenance period. Safety was comparable with 88.6% TEAEs in the ciprofol group compared to 95.5% in the propofol group. The incidence of injection pain was significantly lower in the ciprofol group compared to the propofol group (6.8% vs. 20.5%, p0.05). In addition, the patients treated with ciprofol had a lesser increase in blood pressure and heart rate, and fewer cases with BIS60 within 15 min of intravenous administration, which indicated that ciprofol may provide a better ideal sedation level during the post-induction period under an equivalent dosing regimen to propofol.Ciprofol for patients undergoing selective surgery is a new option for the induction of general anesthesia.

卵圆孔未闭（PFO）与隐源性卒中有明显相关性，通过介入封堵可有效预防缺血性卒中的发生，大部分PFO采用常规操作可以完成介入治疗，极少数复杂型PFO需要应用穿刺房间隔的方法。该文报道一例经食道超声心动图（TEE）证实为复杂型PFO的患者，应用心腔内超声（ICE）指导房间隔穿刺，实时监测与指导PFO封堵过程、封堵伞释放后位置及形态，通过彩色多普勒及超声造影判断有无残余分流。ICE实时指导房间隔穿刺成功，清晰监测PFO封堵伞释放过程，封堵伞对周边结构无影响，术后无残余分流。.

COVID-19, caused by SARS-COV-2, has the characteristics of world epidemic, highly infectious and large base of death. In China, transmission route of SARS-COV-2 has been contained so effectively that COVID-19 has been well controlled due to the proactive national prevention and control strategy. However, not only does it bring a huge impact on the existing medical structure model, but also an objective impact on the treatment of patients with chronic diseases such as malignant tumors. Based on the progress reported in the domestic and international literatures and the actual management experience of our team, this paper reflects on the treatment strategies for patients with gastrointestinal stromal tumor (GIST) during the epidemic period of COVID-19. We focus on risk stratification for primary GIST and forming treatment strategies accordingly. Major considerations include the impact of delayed operation, the burden of medical resources, the waiting time for elective operation, and the principle of emergency operation. In addition, we focus on the level of evidence for non-surgical approaches with a view to developing a holistic strategy of "priority management principles" to guide clinical treatment in the context of limited resources and different GIST priorities.新型冠状病毒（SARS-CoV-2）引起的新型冠状病毒肺炎（COVID-19，以下简称新冠肺炎）具有全球性流行、传染性极强、死亡基数极大的特点。在我国，由于采取了积极主动的全民防控策略，有效遏制了病毒传播的途径，使新冠肺炎得到了很好的控制；但同时，这也对现有条件下的医疗结构模式带来了巨大的冲击，对于恶性肿瘤等慢性疾病患者的治疗产生了客观影响。本文基于国内外文献进展及笔者团队实际处理经验，就胃肠间质瘤（GIST）患者在疫情期间的治疗策略进行思考，重点对原发性GIST进行风险分层，并根据不同分层制定相应的治疗策略，包括延迟手术的影响、医疗资源的利用负担、手术时间等待的紧迫感和急诊手术处理原则等几方面。此外，我们着重探讨了非手术方法的证据级别，以期在资源有限的情况下，针对不同GIST的优先级，建立"优先级处理原则"的整体治疗策略来指导临床治疗。.

The concept of total mesorectal resection provides a quality control standard that can be followed for radical resection of rectal cancer, but some anatomical problems are still controversial. Compared with traditional open surgery, laparoscopic radical rectal surgery has better surgical vision, better neurological protection, better operating space. However, if the surgeon has insufficient understanding of the anatomy, collateral damage may occur, such as uncontrollable bleeding during the operation, postoperative urination and defecation dysfunction and so on. Based on the interpretation of the researches at home and abroad, combined with the clinical experience, we elucidate some associated issues, including anatomic variation of inferior mesenteric vessels, the controversy of inferior mesenteric artery ligation plane, the controversy of lymph node dissection in No. 253, the anatomical variation of middle rectal artery, and the anatomical controversy of lateral lymph node dissection in rectal cancer, in order to provide better cognitive process for the clinical front-line surgeons.全直肠系膜切除的理念为直肠癌的根治手术提供了可以遵循的质量控制标准，但是尚有部分解剖学问题存在争议。腹腔镜直肠癌根治术虽然具有更好的手术视野、更佳的神经功能保护、更大的操作空间，但若术者对解剖结构或解剖变异认知不足，可能会出现术中不可控制的出血、术后排尿排粪功能障碍等副损伤。笔者通过对国内外研究的分析总结，并结合临床经验，针对直肠癌根治术涉及的几个解剖争议问题，包括肠系膜下血管解剖及变异、肠系膜下动脉离断平面的争议、第253组淋巴结清扫的争议、直肠中动脉的解剖学变异及直肠癌侧方淋巴结清扫的解剖学争议等进行阐述，旨在为临床外科医师提供一个更好的认知过程。.

In this work, we investigated the structural properties of ferroelectric PbZr0.2Ti0.8O3 (PZT) and ferrimagnetic/ferroelectric [CoFe2O4(CFO)/PZT] bilayers grown on (001)SrTiO3 (STO) substrat...

In shock stage of extensive burns, the hemodynamics shows inherent and continuously dynamic changes, which gradually transits from " low output and high resistance" in early shock stage to " high output and low resistance" in the stage of edema reabsorption, with significant time-dependence. Normal values of hemodynamic parameters are not the endpoint of resuscitation for burn shock. To pursue the normalization of hemodynamic in shock stage will lead to excessive resuscitation. Urine output per hour is still the " gold standard" for burn shock resuscitation. Dynamic observation of hemodynamic variables can assist clinical treatment, and has more significant roles in refractory shock, cases combined with injuries of heart, lung or kidney, and special populations of the elderly and children.大面积烧伤休克期血流动力学呈现内在的、持续动态的变化规律，由休克早期的"低排高阻"逐渐过渡到回吸收期的"高排低阻"，并具有明显的时间依赖性。血流动力学指标的正常值不是烧伤休克复苏的终点，追求休克期血流动力学的正常化将导致过度复苏。每小时尿量仍然是指导烧伤休克复苏的"金标准"。动态观察血流动力学指标的变化可以辅助临床治疗，在休克复苏不良、心肺肾等脏器功能损害和老年人、儿童等特殊人群具有更大的作用。.

Natural plant dye is selected as the pH sensitive agent of the freshness indicators, and the solvent is used to extract the dyes from six kinds of plants-Xinlimei radish, mulberry, red raisin peel, pitaya peel, red carnation and purple onion peel. The color change in solution with different pH value shows that most plant dyes are very sensitive to change in pH value-red in acid solution and blue in alkaline solution. According to the pH change of the spoilage process of chilled meat, low-temperature smoked sausage, fruits and vegetables, appropriate plant dyes are selected as the freshness indicator agent. The test result shows that Xinlimei radish dye is more suitable as a pH indicator agent for chilled meat and high-acid fruits. The purple onion skin pigment indicator agent can be used for fresh fish and neutral vegetables. The mulberry pigment indicator agent can be used for medium-acid fruits. And the theoretical design of the natural color food freshness indicator label is given.

Scientific research is an essential necessity for the prevention and control of COVID-19. Accelerated paper-sharing makes it possible to explore the responses of scientific communities of different countries and their research focus. This is achieved by examining relevant publications during the early stage of the pandemic. This paper explores a timely research assessment on COVID-19 among China, USA, and EU.Papers indexed in PubMed and published from December 30, 2019, to March 11, 2020, were selected. Papers from China, USA, and EU were assessed by calculating the significance of items in the co-occurrence exported from VOSviewer.The results showed that Chinese studies focus more on clinical manifestations, while USA and EU focus on experimental research. Furthermore, US research is more geared toward detection techniques and mathematical models, China focuses more on monitoring the epidemic situation, and EU engages in both.This paper argues that the above distinctions are caused by differences in the stages of epidemic development, researchers' experience bases for formulating measures, traditions within the different medical cultures, and the distinction between "information" and "knowledge".

In December 2019, a new outbreak of corona virus disease 2019 began to occur. Its pathogen is 2019-nCoV, which has the characteristics of strong infectivity and general susceptibility. The current situation of prevention and control of new coronavirus pneumonia is severe. In this context, as front-line medical workers bearing important responsibilities and pressure, while through strict management strategy, we can minimize the risk of infection exposure. By summarizing the research progress and guidelines in recent years in the fields of colorectal cancer disease screening, treatment strategies (including early colorectal cancer, locally advanced colorectal cancer, obstructive colorectal cancer, metastatic colorectal cancer and the treatment of patients after neoadjuvant therapy), the choice of medication and time limit for adjuvant therapy, the protective measures for patients undergoing emergency surgery, the re-examination of postoperative patients and the protection of medical staff, etc., authors improve treatment strategies in order to provide more choices for patients to obtain the best treatment under the severe epidemic situation of new coronavirus pneumonia. Meanwhile we hope that it can also provide more timely treatment modeling schemes for colleagues.2019年12月，新型冠状病毒肺炎开始暴发流行，其病原体为2019-nCoV，具有感染力强，人群普遍易感的特点。目前新型冠状病毒肺炎的防控形势严峻。在这样的背景下，作为一线的医务工作者肩负着重要的责任和压力，但是通过我们严格的管理策略，可以尽可能地减少感染暴露的风险。笔者通过对近几年的研究进展和指南的归纳总结，从结直肠癌的疾病筛查、治疗策略（包括早期结直肠癌、局部晚期结直肠癌、梗阻性结直肠癌、转移性结直肠癌以及新辅助治疗后患者的治疗）、辅助治疗的药物选择和时限选择、急诊手术患者的防护措施、术后患者复查以及医务人员的防护等方面，进行了治疗策略的改进，以期在新型冠状病毒肺炎疫情严峻的形势下，为广大患者提供更多的选择，以获得最佳的治疗，也为各位同道提供更合时宜的治疗模式。.

In December 2019, a new outbreak of coronavirus pneumonia began to occur. Its pathogen is 2019-nCoV, which has the characteristics of strong infectivity and general susceptibility. The current situation of prevention and control of new coronavirus pneumonia is severe. In this context, as front-line medical workers bearing important responsibilities and pressure, while through strict management strategy, we can minimize the risk of infection exposure. By summarizing the research progress and guidelines in recent years in the fields of colorectal cancer disease screening, treatment strategies(including early colorectal cancer, locally advanced colorectal cancer, obstructive colorectal cancer, metastatic colorectal cancer and the treatment of patients after neoadjuvant therapy), the choice of medication and time limit for adjuvant therapy, the protective measures for patients undergoing emergency surgery, the re-examination of postoperative patients and the protection of medical staff, etc., authors improve treatment strategies in order to provide more choices for patients to obtain the best treatment under the severe epidemic situation of new coronavirus pneumonia. Meanwhile we hope that it can also provide more timely treatment modeling schemes for colleagues.2019年12月，新型冠状病毒肺炎开始暴发流行，其病原体为2019-nCoV，具有感染力强，人群普遍易感的特点。目前新型冠状病毒肺炎的防控形势严峻。在这样的背景下，作为一线的医务工作者肩负着重要的责任和压力，但是通过我们严格的管理策略，可以尽可能地减少感染暴露的风险。笔者通过对近几年的研究进展和指南的归纳总结，从结直肠癌的疾病筛查、治疗策略（包括早期结直肠癌、局部晚期结直肠癌、梗阻性结直肠癌、转移性结直肠癌以及新辅助治疗后患者的治疗）、辅助治疗的药物选择和时限选择、急诊手术患者的防护措施、术后患者复查以及医务人员的防护等方面，进行了治疗策略的改进，以期在新型冠状病毒肺炎疫情严峻的形势下，为广大患者提供更多的选择，以获得最佳的治疗，也为各位同道提供更合时宜的治疗模式。.

Micro-cantilever sensors have shown great promise in a wide range of applications including chemical medical and biological sensing. However, many of these devices are based upon a sensor ‘chip’ that requires careful alignment between the cantilever and the read-out system, which can be challenging. Furthermore, optical interrogation typically involves a bulky free-space system. Optical fiber addressed cantilevers have been reported previously in the literature and in this paper we propose techniques to design and fabricate polymer micro-cantilevers onto the end of standard single mode fibers using ns-laser machining. The cantilever will deflect and thereby observing biological binding between species of interests and activated cantilevers. Proof-of-concept experiments demonstrate that the sensor is capable of detecting Listeria food pathogen concentrations with a minimum level of less than 105cfu/ml.

The aim of this study was to investigate the protective effect of glutamine (Gln) on the intestinal morphology, intestinal inflammatory response, and barrier integrity in broilers exposed to high ambient temperature. Three-hundred-sixty 21-d-old Arbor Acres broilers (half male and half female) were randomly allocated to 4 treatment groups in a completely randomized design, each of which included 6 replicates with 15 birds per replicate, for 21 d. The 4 treatment groups were as follows: the control group, in which birds were kept in a thermoneutral room at 22 ± 1°C (no stress, NS; fed a basal diet); the heat stress group (36 ± 1°C for 10 h/d from 08:00 to 18:00 h and 22 ± 1°C for the remaining time, heat stress (HT); fed a basal diet); and heat stress + Gln group (0.5 and 1.0% Gln, respectively). Compared to the NS group, broilers in the HT group had lower villus height (P < 0.05), higher crypt depth (P < 0.05), higher D-lactic acid and diamine oxidase (DAO) activity (P < 0.05), higher soluble intercellular adhesion molecule-1 (sICAM-1) concentration (P < 0.05), higher tumor necrosis factor (TNF)-α/interleukin (IL)-10 (P < 0.05), and lower tight junction protein expression levels (P < 0.05). Compared with birds in the HT, birds in the HT + Gln group exhibited increased villus height (P < 0.05), decreased D-lactate and DAO activity (P < 0.05), decreased sICAM-1 concentration (P < 0.05), and mediate the secretion of cytokines (P < 0.05), as well as increased zonula occludens-1 (ZO-1), claudin-1, and occludin mRNA expression levels (P < 0.05). In conclusion, these results indicate that supplementation with Gln was effective in partially ameliorating the adverse effects of heat stress on intestinal barrier function in broilers by promoting epithelial cell proliferation and renewal, modifying the function of the intestinal mucosa barrier, and regulating the secretion of cytokines.

Presently, nonalcoholic fatty liver disease has become the most common pathogenic factor of chronic liver disease worldwide that can lead to the occurrence of hepatocellular carcinoma (HCC). Lipid metabolism in cancer cells is closely related to tumorgenesis, invasion and metastasis, and thus acts as one of the hallmark of cancer cells. Lipolipomics is an important branch of metabolomics, which has been adapted recently in the study of HCC for analysis of the structure and function of lipid components by chromatography and mass spectrometry. Fatty acids, glycerides, glycerophospholipids, sphingolipids, and sterol are significantly different in HCC tissues or serum. Therefore, it contributes to the diagnosis, determination of prognosis, mechanistic study and targeted therapy of HCC.目前非酒精性脂肪性肝病已成为全球慢性肝病最常见的致病因素，并可导致HCC（HCC）的发生。脂代谢作为癌细胞的Hallmark之一，与肿瘤发生、发展、侵袭和转移等密切相关。脂质组学是代谢组学的重要分支，通过色谱和质谱技术，分析脂质成分的结构与功能，近年在HCC的研究中得到广泛应用。脂肪酸类、甘油脂类、甘油磷脂类、鞘脂类、固醇脂类等在HCC组织或血清中具有明显差异，有助于HCC的诊断、预后判定、机制研究以及靶向治疗等。.