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Using the nonlinear 3D MHD code JOREK with reduced MHD equations (visco-resistive MHD), we have successfully simulated a recent n = 2 resonant magnetic perturbation (RMP)- driven edge localized mode (ELM) suppression in KSTAR. We have found that such ELM suppression has been attributable not only to the degraded pedestal but also to the direct coupling between the peeling-ballooning mode (PBM) and RMP-driven plasma response. Notably, the pedestal pressure gradient is reduced as the radial transport is enhanced because of the formation of the stochastic layer and increased convection fluxes due to tearing and the kink-peeling mode driven by RMPs. The increased transport in the stochastic layer is due to the parallel transport across the stochastic fields, described by the Braginskii model in the simulation. While the linear stability of the PBM improves owing to the degraded pedestal, it is not a sole contributor to ELM suppression, in that the nonlinear mode coupling plays a more critical role. This outcome is consistent with previous studies where mode coupling affects the ELM mitigation or suppression. In addition, PBM locking has been numerically achieved during the ELM suppression phase, which may support the relationship between VE×B ≈ 0 at the pedestal and the onset of ELM suppression. We suggest that PBM locking can enhance the mode interactions between RMPs and PBMs, which is significant for ELM suppression.

A small relaxation of the axisymmetric magnetic field of a tokamak into a non-axisymmetric three-dimensional (3D) configuration can be effective to control magnetohydrodynamic instabilities, such as edge-localized modes. However, a major challenge to the concept of 3D tokamaks is that there are virtually unlimited possible choices for a 3D magnetic field, and most of them will only destabilize or degrade plasmas by symmetry breaking. Here, we demonstrate the phase-space visualization of the full 3D field-operating windows of a tokamak, which allows us to predict which configurations will maintain high confinement without magnetohydrodynamic instabilities in an entire region of plasmas. We test our approach at the Korean Superconducting Tokamak Advanced Research (KSTAR) facility, whose 3D coils with many degrees of freedom in the coil space make it unique for this purpose. Our experiments show that only a small subset of coil configurations can accomplish edge-localized mode suppression without terminating the discharge with core magnetohydrodynamic instabilities, as predicted by the perturbative 3D expansion of plasma equilibrium and the optimizing principle of local resonance. The prediction provided excellent guidance, implying that our method can substantially improve the efficiency and fidelity of the 3D optimization process in tokamaks. A theoretical and numerical approach, validated by experiments at the KSTAR facility, shows how magnetohydrodynamic instabilities in tokamak plasmas can be efficiently controlled by a small relaxation of the confining field into a 3D configuration.

A newly developed plasma response model, combining the nonlinear two-fluid MHD code TM1 and toroidal MHD code GPEC run in ideal mode, quantitatively predicts the narrow isolated q95 windows (Δq95 ∼ 0.1) of edge-localized mode (ELM) suppression by n = 1, 2, and 3 resonant magnetic perturbations (RMPs) in both DIII-D and KSTAR tokamaks across a wide range of plasma parameters. The key physics that unites both experimental observations and our simulations is the close alignment of essential resonant q-surfaces and the location of the top of the pedestal prior to an ELM. This alignment permits an applied RMP to produce field penetration due to the lower E × B rotation at the pedestal top rather than being screened. The model successfully predicts that narrow magnetic islands form when resonant field penetration occurs at the top of pedestal, and these islands are easily screened when q95 moves off resonance, leading to very narrow windows of ELM suppression (typically Δq95 ∼ 0.1). Furthermore, the observed reduction in the pedestal height is also well captured by the calculated classical collisional transport across the island. We recover observed q95, βN and plasma shape dependence of ELM suppression due to the effect of magnetic islands on pedestal transport and peeling-ballooning-mode stability. Importantly, experiments do occasionally observe wide windows of ELM suppression (Δq95 > 0.5). Our model reveals that at low pedestal-top density multiple islands open, leading to wide operational windows of ELM suppression consistent with experiment. The model indicates that wide q95 windows of ELM suppression can be achieved at substantially higher pedestal pressure with less confinement degradation in DIII-D by operating at higher toroidal mode number (n = 4) RMPs. This can have significant implications for the operation of the ITER ELM control coils for maintaining high confinement together with ELM suppression.

Since the initial long-pulse H-mode operation in 2012, the H-mode has been sustained longer and the operational regime of plasma parameters has been significantly extended in KSTAR tokamak. The progress in long-pulse operation is mainly due both to the increased NBI heating power of PNBI ∼ 3.5 MW and the advance in the shaping control which is not trivial with slow superconducting coils. In 2013 campaign, the duration of H-mode phase has been extended up to 25 sec with 0.5 MA of plasma current and 3 MW of PNBI and, in the coming campaign as main operational goal, it is expected to be extended up to more than 30 sec using 5 MW of PNBI. In addition, in 2014 campaign, the long-pulse operation will be in accordance with ITER requirement, i.e., in ITER similar shape, low safety factor (q95∼3) and normalized beta (∼2.0) with real-time control of density and power. ELM suppression is discovered in wide range of coil configuration and the suppression window in the safety factor q95 has extended from 6.5 to 3.9 depending on the configuration, i.e., q95∼6.5 for n=1, q95∼5.0 for the mixed n=1 & n=2, and q95∼4.0 for n=2 indicating the strong impact of resonant component on ELM suppression. In addition to the suppression, strong mitigation of ELM, i.e., order of magnitude increase of ELM frequency (fELM), has been also demonstrated in wide range of non-resonant field configuration. Significant progress has been on the investigation of the underlying mechanism on RMP suppression using measurements of pedestal fluctuations and modeling of plasma response especially for n=1 case where field penetration is global and full response modeling is required including the sielding effect of toroidal rotation. Since the initial 2 segment measurements in 2012, detailed evaluation of error field (EF) has been performed by 4 segment compass scan by measuring maximum current in middle internal coils for each quadrant. In agreement with the previous measurements, the measured level of intrinsic error field is at order of 10−5 at the magnetic axis, which is an order of magnitude lower than other tokamaks. Not only for the 3D RMP experiments, both low level of error field and versatile in-vessel 3D coils provide ideal platform to investigate momentum transport and MHD stability without complicated influence of residual error field. Strong focus is on the extended identification of detailed pattern of n=1 error field utilizing the full poloidal sets of internal coils and its impact on the operational boundary is investigated especially for q95 range below three where effect of error field is critical due to the locked mode and MHD activities. Including above topics, the presentation will address the recent results on rotation & transport physics, newly installed diagnostics, MHD activities and the future plan

© 2015 AIP Publishing LLC. Using three-dimensional nonlinear simulations of tokamak turbulence, we show that an edge transport barrier (ETB) forms naturally once input power exceeds a threshold value. Profiles, turbulence-driven flows, and neoclassical coefficients are evolved self-consistently. A slow power ramp-up simulation shows that ETB transition is triggered by the turbulence-driven flows via an intermediate phase which involves coherent oscillation of turbulence intensity and E × B flow shear. A novel observation of the evolution is that the turbulence collapses and the ETB transition begins when RT> 1 at t = tR(RT: normalized Reynolds power), while the conventional transition criterion (ω E × B > γ l i n where ω E × B denotes mean flow shear) is satisfied only after t = tC( >tR), when the mean flow shear grows due to positive feedback.

The guiding-center kinetic neoclassical transport code, XGC0, [C.S. Chang et. al, Phys. Plasmas 11, 2649 (2004)] is used to compute the heat fluxes and the heat-load width in the outer divertor plates of Alcator C-Mod and DIII-D tokamaks. The dependence of the width of heat-load fluxes on neoclassical effects, neutral collisions and anomalous transport is investigated using the XGC0 code. The XGC0 code includes realistic X-point geometry, a neutral source model, the effects of collisions, and a diffusion model for anomalous transport. It is observed that width of the XGC0 neoclassical heat-load is approximately inversely proportional to the total plasma current $I_{\rm p}$. The scaling of the width of the divertor heat-load with plasma current is examined for an Alcator C-Mod discharge and four DIII-D discharges. The scaling of the divertor heat-load width with plasma current is found to be weaker in the Alcator C-Mod discharge compared to scaling found in the DIII-D discharges. The effect of neutral collisions on the $1/I_{\rm p}$ scaling of heat-load width is shown not to be significant. Although inclusion of poloidally uniform anomalous transport results in a deviation from the $1/I_{\rm p}$ scaling, the inclusion of the anomalous transport that is driven by ballooning-type instabilities results in recovering the neoclassical $1/I_{\rm p}$ scaling. The Bohm or Gyro-Bohm scalings of anomalous transport does not strongly affect the dependence of the heat-load width on plasma current. The inclusion of anomalous transport, in general, results in widening the width of neoclassical divertor heat-load and enhances the neoclassical heat-load fluxes on the divertor plates. Understanding heat transport in the tokamak scrape-off layer plasmas is important for strengthening the basis for predicting divertor conditions in ITER., Comment: Submitted to Physics of Plasmas

Breakdown voltages of a capacitively coupled radio frequency argon discharge at 27 MHz are studied. We use a one-dimensional electrostatic PIC code to investigate the effect of changing the secondary emission properties of the electrodes on the breakdown voltage, particularly at low pd values. Simulation results are compared with the available experimental results and a satisfactory agreement is found.

A study is conducted on the impact of plasma compressibility on the stability of drift ballooning modes. The two-fluid and four-field model developed by Hazeltine et al. [Phys. Fluids 28, 2466 (1985)] is employed in this study. Results of linear numerical simulations show that finite compressibility destabilizes ballooning modes which are otherwise stable due to the ion diamagnetic drift effect. A systematic study reveals that the parallel compressibility originating from the two-fluid effect, rather than the drift-acoustic wave coupling suggested by Hastie et al. [Phys. Plasmas 10, 4405 (2003)], plays the most important role in destabilizing the ballooning modes. An analytic evaluation of the dispersion relation underpins the strong sensitivity of this parallel compressibility term in the ballooning mode stability. The potential impact of this new understanding on the physics of small edge localized modes is discussed.

On the basis of three-dimensional nonlinear magnetohydrodynamic simulations, we propose a new dynamical process leading to the stochastization of magnetic fields during an edge pedestal collapse. Primary tearing modes are shown to grow by extracting kinetic energy of unstable ballooning modes, eventually leading to the island overlap. Secondary tearing modes, which are generated through a coherent nonlinear interaction between adjacent ballooning modes, play a key role in this process, mediating the energy transfer between primary ballooning and tearing modes. Explicit calculations of the parallel energy loss through the stochastic field lines show that it can be a likely dominant energy loss mechanism during an edge pedestal collapse., 12 pages, 5 figures

Polyclonal antibodies against specific carboxy-terminal sequences of known alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunits (GluR-4) were used to screen regional homogenates and subcellular fractions from rat brain. Affinity purified anti-GluR1 (against amino acids 877-899), anti-GluR2/3 (850-862), and anti-GluR4a and anti-GluR4b (868-881) labeled distinct subunits with the expected molecular weight of approximately 105,000. These antigens were shown to have distinct distributions in the brain. While GluR2/3 epitopes had a distribution profile similar to that of the presynaptic marker synaptophysin, GluR1 was notable for its abundance in the hippocampus and its relatively low density in neocortical areas, and GluR4 was highly enriched in cerebellar tissue. An additional antigen (glutamate receptor-related, GR53) of lower molecular weight (50,000-59,000) was recognized in rat, human, frog, chick and goldfish brain samples by anti-GluR4a as well as by anti-GluR1 at, an antibody that specifically recognizes the extracellular aminoterminal domain of GluR1 (amino acids 163-188). Both antibodies also labeled antigens of approximately 105,000 mol. wt in brain tissue from all species tested. The approximately 53,000 mol. wt antigen was concentrated 10-20-fold in synaptic membranes vs homogenates across rat brain regions. Both the 105,000 and the 53,000 mol. wt proteins were also concentrated in postsynaptic densities, and neither of the two antigens were evident in seven non-brain tissue samples. These data indicate that AMPA receptors have regionally different subunit combinations and that some AMPA receptor composites include proteins other than the conventional 105,000 mol. wt GluR subunits.

Human enteroviruses (HEVs) are a major cause of herpangina, HFMD (hand, foot, and mouth disease), and other neurological diseases in Seoul, Korea.A total of 56 specimens from hospitalized patients collected from February to December 2009 (37 females and 19 males) in Seoul were tested for HEV from stool, throat swab, and vesicle swab samples taken from patients with herpangina or HFMD using cell culture and RT-PCR in 2009. By the 1D gene, encoding the VP1 capsid protein, seven different HEV genotypes were detected with Coxsackievirus A2, A4, A5, A9, A16 (CA), Coxsackievirus B1 (CB), and Enterovirus 71 (EV71). The most prevalent genotype was CA16 (6, 10.7%), followed by CA2 (4, 7.1%), CA5 (4, 7.1%), EV71 (2, 3.6%), CA4 (1, 1.8%), CA9 (1, 1.8%), and CB1 (1, 1.8%). The 1D gene sequences of two EV71 strains were closely related with one another (98.5% nucleotide similarity) and belonged to the C4 genotype.It is important to continuously survey the genetic characteristics of EV71 and CA16 from patients, which will provide useful data that aids in our understanding of HFMD infections in Seoul, Korea and may contribute to future control.

The molecular basis of the genetic vulnerability underlying the most common form of clinical tuberculosis (TB) remains largely unknown. We speculated that mild genetic defects in the interferon-gamma (IFN-gamma) signalling pathway caused a subtle functional impairment of IFN-gamma which would explain susceptibility to Mycobacterium tuberculosis in clinical TB.A case-control study.We evaluated functional responsiveness to IFN-gamma in monocytes from patients with clinical TB (n = 10), and analysed the genetic sequences of the IFN-gamma receptor 1 (IFN-gammaR1) and STAT1 genes in patients with disseminated TB (n = 18). IFN-gamma stimulated an increase in the expression of HLA-DR and CD64 on monocytes of both controls and patients; the rate of increase in expression was the same in both groups. Treatment with IFN-gamma before lipopolysaccharide (LPS) stimulation further increased tumour necrosis factor-alpha (TNF-alpha) production as compared to TNF-alpha production with LPS stimulation alone; the rate of increase in TNF-alpha production was the same in both groups. The known mutations in the coding sequences of the IFN-gammaR1 and STAT1 genes were not found in the patients with disseminated tuberculosis.These results suggest that impairment of the IFN-gamma signalling pathway did not account for cases of clinical TB in this study.

Various membranes, which have different materials and nominal molecular weight cut-offs (MWCO), were compared in terms of rejection of ibuprofen and removal of effluent organic matter (EfOM) from membrane bioreactor (MBR), because pharmaceutical compounds contain a potential risk and EfOM is the precursor of carcinogenic disinfection by-products when reusing for drinking water source. To provide equivalent comparison with respect to hydrodynamic condition, mass transfer parameter, J0/k ratio, was used. A tight-UF membrane with a molecular weight cut off of 8,000 daltons exhibited 25 approximately 95% removal efficiencies of ibuprofen with a molecular weight of 206 with and without presence of EfOM(MBR). EfOM(MBR) caused the reduction of ibuprofen removal efficiency for UF membrane. Rejection of EfOM(MBR) by UF and NF membranes ranged 29 approximately 47% and 69 approximately 86%, respectively. UF membrane could successfully remove ibuprofen at lower J0/k ratio range (or = 1) in organic free water but could not efficiently reject ibuprofen with a relatively hydrophilic EfOM(MBR) (SUVAor = 3).

The use of cultured hippocampal slices for studies of calpain-mediated pathogenesis was investigated. Breakdown products (BDPs), which result from proteolysis of spectrin by calpain I, were assayed with BDP-specific antibodies developed against peptide sequences on either side of the calpain cleavage site. The antibodies recognized either amino- or carboxy-terminal BDPs (147-kD BDPN and 152-kD BDPC, respectively). Various pathogenic manipulations, including trimethyltin, certain snake venoms and agonists for excitatory amino acid receptors, were found to cause rapid and pronounced increases in the proteolytic fragments. These effects were selective, i.e., chemicals or toxins directed at nonglutamatergic neurons had little effect on BDP concentrations. Transient accumulations of spectrin fragments were obtained with brief applications of N-methyl-D-aspartate; longer infusions resulted in lasting increases. Results similar to these have been observed in vivo with ischemic episodes of varying duration. Agonists of the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid subclass of glutamate receptors produced significant increases in spectrin proteolysis; however, prolonged exposure of the slices to centrally active drugs that enhance the currents passed by the receptors did not. The sensitivity, selectivity and temporal properties of the proteolytic response support the idea that cultured slices can be used to analyze the events leading to and following from calpain activation in the adult brain.

Recent experiments in the low aspect ratio National Spherical Torus Experiment (NSTX) have been run in support of the high priority ITER and ITPA issue of access to the H-mode. Specifically, a series of experiments showed reduced power threshold values for deuterium vs helium plasmas, and for plasmas with lower current, lower triangularity and with lithium conditioning. Application of n=3 fields at the plasma edge resulted in higher power thresholds. To within the constraints of temporal and spatial resolutions, no systematic difference in T{sub e}, n{sub e}, p{sub e}, T{sub i}, v or their derivatives was found in discharges that transitioned into the H-mode versus those at slightly lower power that did not. Finally, H{sub 98y,2} {approx} 1 confinement quality could be achieved for powers just above the threshold power in ELM-free conditions.

A summary of results from recent L–H power threshold (P LH) experiments in the National Spherical Torus Experiment is presented. First P LH (normalized linearly by plasma density) was found to be a minimum in double-null configuration, tending to increase as the plasma was shifted more strongly towards lower- or upper-single null configuration with either neutral beam or rf heating. The measured P LH/n e was comparable with neutral beam or rf heating, suggesting that rotation was not playing a dominant role in setting the value of P LH. The role of triangularity (δbot) in setting P LH/n e is less clear: while 50% less auxiliary heating power was required to access H-mode at low δbot than at high δbot, the high δbot discharges had lower ohmic heating and higher dW/dt, leading to comparable loss of power over a range of δbot. In addition, the dependences of P LH on the density, species (helium versus deuterium), plasma current, applied non-axisymmetric error fields and lithium wall conditioning are summarized.

The evolution of electron temperature in a low pressure magnetized capacitive discharge was investigated under the collisionless electron heating regime. The results showed that while the electron temperature increases monotonously with the magnetic field in previous study [Turner et al., Phys. Rev. Lett. 76, 2069 (1996)], the electron temperature in our experiment exhibited nonmonotonic evolution behavior with the magnetic field. This nonmonotonic evolution of the electron temperature with the magnetic field was shown to be a combined effect of suppressing electron resonance heating and enhancing collisional heating while increasing the magnetic field.

Resonant magnetic perturbations (RMPs) have been found effective in suppressing edge localized modes (ELMs) in the DIII-D experiment (Evans et al 2006 Phys. Plasmas 13 056121, Moyer et al 2005 Phys. Plasmas 12 056119). Simulations with the M3D initial value code indicate that plasma rotation, due to an MHD toroidal rotation or to two-fluid drifts, has an essential effect on the RMP. When the flow is below a threshold, the RMP field can couple to a resistive mode with a helical structure, different from the usual ELM, that amplifies the non-axisymmetric field. The magnetic field becomes stochastic in the outer part of the plasma, causing density and temperature loss. At higher rotation speed, the resistive mode is stabilized and the applied RMP is screened from the plasma, so that the stochastic magnetic layer is thinner and the temperature remains similar to the initial unperturbed state. The rotational flow effects, along with the remnants of the screened RMP, cause a density loss which extends into the plasma core. The two-fluid model contains intrinsic drift motion and axisymmetric toroidal rotation may not be needed to screen the RMP nor stabilize the resistive mode.

Bone marrow-derived mesenchymal stem cells (MSCs) have the potential to differentiate into a variety of cell types, including osteocytes, chondrocytes, and adipocytes. Moreover, MSCs have the capacity to differentiate into neural lineages. The present study aimed to investigate the differences between the expression profiles during neural differentiation of rat and cat MSCs. MSCs in the 4th passage, which were isolated from the femurs and tibias by standard methodology, were used in our study. Culture media was divided into pre-induction medium, which consisted of DMEM-HG, 10% fetal bovine serum, 10 ng mL-1 of basic fibroblast growth factor (bFGF), and 1 mM �-mercaptoethanol, for 24 h, and neuron induction medium, which was composed of DMEM-HG, 2% DMSO, 200 �M BHA, 25 mMKCl, 10 �M forskolin, 5 �g mL-1 insulin-transferrin-sodium selenite, and 20 ng mL-1 bFGF, for 24 h. Thereafter, cell morphology and growth traits were determined by light microscopy imaging and by examining the cell-surface antigen profile and differentiation repertoire by immunocytochemistry, respectively. Regarding the expression of 3 MSC-related surface antigens, rat cells were positive for CD18 and CD44, whereas cat cells expressed CD9 and CD44. Under proneurogenic conditions, rat neuron-like cells progressively increased at 30 min post-induction, peaked at 1 h, and gradually declined after 12 h. At 24 h after neural induction, there were still some neuron-like cells. Meanwhile, cat cells were expressed increasingly during the first hour, peaked at 2 to 3 h, were sustained for 8 h after neural induction, and then gradually declined.A few neuron-like cells remained until 24 h post-induction. In neural differentiation, rat MSCs were positive for �III-tubulin, NF-L, NF-M, NF-H, trkA, and vimentin; cat MSCs were negative for �III-tubulin and NF-H but positive for NF-L, NF-M, trkA, and vimentin. Both MSCs were negative for oligodendrocyte markers. Our results revealed that there is variation in neural differentiation sensitivity due to species type. Rat cells were more sensitive in response to neuroinduction agents, maintained their morphology for a longer time, and expressed relatively mature neuronal markers. On the contrary, the sensitivity of cat cells was weaker, and survival time was shorter compared to that of the rat cells. The cat cells expressed immature neuronal markers. The present data suggest a significant aspect of the culture of MSCs from higher-grade species. This work was supported by KOSEF (Grant ? M10525010001-05N2501-00110).