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The epoxides undergo ring-opening reaction smoothly with various amines in an ionic liquid namely 1-butyl-3-methylimidazolium tetrafluoroborate (bmim BF4) under mild reaction conditions. All the reactions were carried out at ambient temperature to afford the corresponding β-aminoalcohols in excellent yields. The ionic liquid was recovered and reused in further reactions with very good efficiency.

We report herein an easy oxidation procedure for converting aromatic aldehydes to aromatic carboxylic acids by use of a combination of commercially and readily available potassium bromate with potassium bromide in the presence of hydrochloric acid catalyst.

Natural product analogs are significant sources for therapeutic agents. To capitalize efficiently on the effective features of naturally occurring substances, a natural product-based library production platform has been devised at Aurigene for drug lead discovery. This approach combines the attractive biological and physicochemical properties of natural product scaffolds, provided by eons of natural selection, with the chemical diversity available from parallel synthetic methods. Virtual property analysis, using computational methods described here, guides the selection of a set of natural product scaffolds that are both structurally diverse and likely to have favorable pharmacokinetic properties. The experimental characterization of several in vitro ADME properties of twenty of these scaffolds, and of a small set of designed congeners based upon one scaffold, is also described. These data confirm that most of the scaffolds and the designed library members have properties favorable to their utilization for creating libraries of lead-like molecules.

Reaction of the methoxyenones 3 and 11 with an excess of boron trifluoride etherate furnishes cleanly the chiral bicyclo[2.2.2]octa-5,7-dien-2-ones 9 and 12 respectively.

The Chalcone derivative, ethoxy methoxy chalcone (EMC), has been prepared by the condensation of paraethoxybenzaldehyde and paramethoxyacetophenone. The NMR and X-ray powder diffraction studies confirm the formation of the compound. It was hot-pressed under various hot-pressing conditions and optimised to yield near-transparent samples. The X-ray diffraction patterns obtained for the hot-pressed samples are consistent with that of the starting material. The microstructural characteristics of these samples have been studied as a function of the hot-pressing conditions. The avarage size of the crystallite has been found to increase on annealing at 80°C. The dielectric property has been found to depend on the microstructural characteristics of the hot-pressed samples. The second harmonic generation (SHG) studies have been carried out using the 1064 nm radiation of a Nd:YAG laser. The SHG efficiency of these samples has been found to vary as a function of the hot-pressing conditions.

Highly stereoselective syntheses of two C-12 chiral synthons 3 and 9, mentioned in the title, starting from the monoterpenes R-1 imonene and R-carvone, using radical cyc 1 sation as key reaction, are described.

Addition of tri-n-butyltin radical to a 5-(prop-2-ynyl)bicyclo[2.2.2]oct-2-ene followed by 5-exo-trig cyclisation of the resulting vinyl radical furnishes an isotwistane, providing a short route to the sesquiterpenes, pupukeananes 4 and 2.