134 results on '"G. Podevin"'
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2. Apendicitis y peritonitis apendicular en el niño
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F. Bastard and G. Podevin
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- 2022
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3. Politraumatismos en el niño
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F. Bastard, K. Bin, F. Richard, G. Podevin, and F. Schmitt
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- 2022
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4. Urgenze chirurgiche neonatali e del lattante
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G. Podevin and F. Schmitt
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03 medical and health sciences ,030219 obstetrics & reproductive medicine ,0302 clinical medicine ,030225 pediatrics ,media_common.quotation_subject ,General Medicine ,Art ,Humanities ,media_common - Abstract
Riassunto Le urgenze chirurgiche nei bambini piccoli coprono molte patologie, che possono diventare rapidamente pericolose per la vita e che sono, quindi, importanti da conoscere. Richiedono un trattamento appropriato in un ambiente specializzato, seguendo un processo diagnostico rigoroso basato principalmente sull’eta del paziente e sui sintomi clinici. Nei neonati, sono causate principalmente da malformazioni congenite toraciche, addominali o urinarie. Il miglioramento della diagnosi prenatale ha completamente cambiato le condizioni dell’assistenza iniziale per la maggior parte di loro e consente alle famiglie di essere informate precocemente. Anche la loro prognosi e molto migliorata negli ultimi anni grazie al progresso delle tecniche di rianimazione neonatale e alla perfetta collaborazione medicochirurgica. Nel lattante, le urgenze chirurgiche sono principalmente digestive, comprese la stenosi pilorica, l’invaginazione intestinale acuta, l’ernia strozzata e, meno frequentemente, l’appendicite acuta. L’esame obiettivo e l’ecografia addominale confermano la diagnosi, evitando qualsiasi ritardo terapeutico e garantendo una guarigione senza sequele.
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- 2021
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5. Urgencias quirúrgicas en recién nacidos y lactantes
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G. Podevin and F. Schmitt
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03 medical and health sciences ,0302 clinical medicine ,030211 gastroenterology & hepatology ,030204 cardiovascular system & hematology - Abstract
Resumen Las urgencias quirurgicas en los ninos pequenos abarcan muchas patologias, que pueden convertirse rapidamente en una amenaza para la vida y, por lo tanto, es importante tenerlas en cuenta. Necesitan un tratamiento adaptado en un entorno especializado, siguiendo un riguroso proceso de diagnostico basado principalmente en la edad y las manifestaciones clinicas del paciente. En el recien nacido, estan causadas principalmente por malformaciones congenitas del torax, el abdomen o las vias urinarias. Los adelantos en el diagnostico prenatal han cambiado por completo las condiciones para el tratamiento inicial de la mayoria de ellos y permite la informacion temprana de las familias. Su pronostico tambien ha mejorado mucho en los ultimos anos gracias a los avances en las tecnicas de reanimacion neonatal y a la perfecta cooperacion medica y quirurgica. En los lactantes, las urgencias quirurgicas son basicamente digestivas, como la estenosis pilorica, la invaginacion intestinal aguda, la hernia estrangulada y, con menor frecuencia, la apendicitis aguda. La exploracion fisica y la ecografia abdominal pueden confirmar el diagnostico, evitando cualquier retraso terapeutico que garantizaria una curacion sin secuelas.
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- 2020
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6. Maladie de Hirschsprung, diagnostic et prise en charge actuelle
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F. Bastard and G. Podevin
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Enterocolitis ,Suction (medicine) ,medicine.medical_specialty ,business.industry ,Gastroenterology ,Disease ,medicine.disease ,Short bowel syndrome ,digestive system diseases ,Surgery ,Internal Medicine ,Medicine ,medicine.symptom ,Neural crest cell migration ,business ,Live birth ,Neonatal bowel obstruction ,Rare disease - Abstract
Hirschsprung disease is a congenital malformation in which, due to lack of neural crest cell migration, the distal part of the bowel has no innervation, leading to functional obstruction. This rare disease (1/5000 live birth) has a complex genetic and physiopathologic background. Depending on the disease level, symptoms vary from distal obstruction to short bowel syndrome. Diagnosis is based on suction rectal biopsy examination and contrast enema. After the obstruction relief, surgical cure aim to remove the aganglionic bowel and to perform laparoscopic or transanal pullthrough. Enterocolitis or anal soiling in childhood can disturb follow up.
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- 2015
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7. Psychopathologie des mésusages du Subutex® : le syndrome de Popeye
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G. Podevin and J. Békaert
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medicine.medical_specialty ,business.industry ,Addiction ,media_common.quotation_subject ,Psychological intervention ,Poison control ,Suicide prevention ,Psychiatry and Mental health ,Arts and Humanities (miscellaneous) ,Feeling ,Injury prevention ,medicine ,Anxiety ,medicine.symptom ,Set (psychology) ,Psychiatry ,business ,media_common - Abstract
INTRODUCTION: High dose buprenorphine (HDB), commonly known as Subutex(®), is nowadays largely prescribed as a replacement therapy for major opiate dependence. Its sublingual administration allows a decrease in the withdrawal syndrome accompanying opiate abuse cessation. Over the past few decades, epidemiological data on people on replacement therapy have emphasized an increase in the misuse of Subutex(®) and more specifically intravenous injections of HDB. These growing practices pave the way to major physical consequences or even death. Several studies have highlighted the infectious, vascular, venous and arterial (pseudo-aneurysm) complications stemming from this habit. Among the possible vascular complications, we can notice the presence of abscess, venous thrombosis, phlegmons, skin necrosis, cellulite, and profound and superficial thrombophlebitis at injection sites. These can evolve into chronic edemas of the tips and subcutaneous nodules. The Popeye syndrome is one of the possible complications of this misuse. This syndrome is characterized by the swelling of both sides of the forearms and hands. These edemas tend to become persistent and to be paired with tissue changes such as skin thickening. Besides, the increase in the hands volume can occur bilaterally or sometimes in an asymmetrical way, accentuated on the hand of the non-dominant limb. This syndrome does not decrease, or just a little, after the stoppage of injections. It can have a psychological, social, psychopathological and esthetic impact. OBJECTIVES: In this article, we will focus on the clinical case of a 43-year-old man, who is hospitalized in an addictology unit for massive injections of HDB. This patient suffers from a Popeye syndrome as well as from an alcoholic dependence. METHOD: Following the description of psychopathological disorders, our analysis will originate from a clarification relative to the specificities of the practice of intravenous HDB injection to better sharpen the understanding of these misuses in their psychopathological and clinical aspects. We will discuss some proposals for interventions aiming at taking better care of the people suffering from a drug addiction characterized by the injection of HDB replacement therapy. RESULTS: Adam requested an admission in an addictology ward for treatment of a self-medication by Subutex started 4 years ago. A certain awkwardness can be perceived when he lays his highly damaged and marked hands on the desk. His upper limbs, thus on display, have tripled in volume: this indicates the presence of a Popeye syndrome, consequence of repeated Subutex injections. These observations lead us to question the function and the sense of this injection behavior in the mental economy, as this repeated behavior engages the body specifically. This bruised body, marked with repeated injection holes has become a place of inscription, of representation that shows the impossibility to access other ways of expression. In this sense, taking action is becoming an act of speech. Within this speech, we can notice the existence of a profound state of uneasiness. To put up with the painful feeling of inner emptiness that is calling for a necessary filling, aiming at re-establishing a frail balance, Adam appeals to repeated injections. However, when the tortured body signifies its incapacity to receive an ultimate injection, thus showing its limits and the destruction it is undergoing, it is no longer possible to resort to Subutex injections. As a consequence, Adam came up with the idea of quitting. The withdrawal was initiated by himself and not coupled with medical care. It has led him to feel a gap, beyond the physical uneasiness. Adam has tried to fill in this unbearable feeling of empty body with tobacco, alcohol and food. The body, highly mobilized, translates the presence of a physical conflict where a massive mental anxiety is expressed in a hidden way. During the interview, Adam also addressed the repetitive familial pattern and the transgeneration effects. He seems to be fully aware of these. DISCUSSION: Several perspectives can be addressed as part of Adam's treatment and especially cognitive-behavioral therapies as they could prove to be of a certain interest. The aim of this therapy would thus be to assess the motivation for change in order to begin a psychotherapeutic work based on personal adherence to the cessation of this misuse. This could be set up in parallel with an anxiety management work. CONCLUSION: A better understanding and an extensive knowledge of the possible complications linked to the misuse of HDB seems necessary to sensitize and better inform people who suffer from high-risk behaviors and also to enable a more adapted care. Language: fr
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- 2015
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8. Bronchial Mucoepidermoid Carcinoma in a 14-year-old Patient
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Bastard François, G Podevin, M Ammi, F Schmitt, MC Rousselet, B Enon, and J Picquet
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stomatognathic diseases ,medicine.medical_specialty ,Mucoepidermoid carcinoma ,business.industry ,medicine ,General Agricultural and Biological Sciences ,medicine.disease ,business ,Dermatology - Abstract
A bronchial mucoepidermoid carcinoma is a rare malignant tumour. It usually appears in young subjects and most often involves the salivary glands. We report the case of a 14-year-old patient who presented with a pulmonary mucoepidermoid carcinoma that was discovered during the evaluation of a case presenting with recurrent pneumopathies.
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- 2017
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9. Apendicitis y peritonitis apendicular en el niño
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G. Podevin
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- 2014
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10. Perception émotionnelle des mouvements élémentaires : incidence sur les processus mnésique et exécutif
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J. Békaert, Stéphane Rusinek, G. Podevin, and Alhadi Chafi
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General Psychology - Abstract
Resume L’objectif des deux experiences presentees consiste a explorer le lien entre perception de mouvements elementaires associes a une valence emotionnelle et processus cognitifs-emotionnels. Les resultats obtenus mettent en evidence que la visualisation de mouvement « positif » et « negatif » induit une perception d’ordre emotionnelle qui provoque des modifications sur les processus cognitifs de memorisation et d’execution de tâche de decomptage.
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- 2012
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11. Hémangiomes infantiles syndromiques (syndromes PELVIS et PHACES) traités par propranolol per os : 4 cas
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M. Delion, D. Loisel, L. Martin, A. Roser, C. Beauchêne, J. Delaunay, H. Nussman, and G. Podevin
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Dermatology - Abstract
Introduction Les syndromes PELVIS et PHACES associent un hemangiome (HI) segmentaire et de multiples anomalies malformatives, respectivement dans la region abdomino-pelvienne et l’extremite cephalique. Depuis 2014, les HI qui engagent le pronostic vital ou fonctionnel ou qui sont compliques d’ulcerations peuvent etre traites par le propranolol (P) per os. Nous decrivons l’interet de ce traitement dans 3 cas de PELVIS et 1 cas de PHACES. Observations Tous les enfants porteurs d’un PHACES ou d’un PELVIS diagnostiques en 2016 dans notre CHU ont ete traites par P. Aucune dysplasie arterielle susceptible de se compliquer d’une occlusion sous betabloqueur n’etait objectivee en angio-MR. Dans les 4 cas, on introduisait le traitement a une dose initiale de 1 mg/kg/jour, dose que l’on augmentait progressivement jusqu’a 3 mg/kg/jour, en 2 prises par jour. Le P etait bien tolere chez les 4 enfants ( Fig. 1 et Tableau 1 ). Discussion Ces 4 HI syndromiques, parfois compliques localement, ont ete traites avec succes par P. Cette utilisation n’est pas precisee dans l’autorisation de mise sur le marche (AMM) et la duree optimale de traitement n’est pas connue dans ces situations. Dans tous les cas, le P a participe a la reduction globale et rapide du volume de l’HI et a l’amelioration des ulcerations superficielles quand elles etaient presentes. Cette evolution favorable etait constatee des la consultation a 1 mois, delai comparable aux donnees de la litterature pour les HI de taille usuelle. Dans un cas (n o 1), une chirurgie de derivation des selles et des urines a participe a la cicatrisation du siege. Dans les autres cas, la prise en charge dermatologique etait assuree par soins locaux et P seul. La tolerance a ete satisfaisante dans tous les cas. Dans la litterature, les cas d’HI syndromiques traites par P sont rares et concernent surtout des syndromes PHACES mais peu de syndromes PELVIS. L’evolution et la securite d’emploi y paraissent non differentes des HI « classiques ». La limite de nos observations est le caractere non controle de la demonstration d’efficacite, quand l’evolution naturelle d’un HI est de s’ameliorer spontanement. Toutefois, compte tenu de la rarete de ces syndromes il est improbable que des essais comparatifs soient mis en place. Conclusion Nous suggerons que le propranolol figure dans l’algorithme de prise en charge dermatologique des HI segmentaires compliques ou non des syndromes PELVIS et PHACES.
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- 2017
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12. Enurésies de l'enfant
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G. Podevin, L. Lenormand, C. Laplace, M.-D. Leclair, Y. Heloury, and Carmen Capito
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Philosophy ,General Medicine ,Humanities - Abstract
Resume L'enuresie se definit comme une miction active et complete survenant a un moment ou a un endroit inapproprie ou socialement inacceptable (enfant de plus de 5 ans). L'enfant avec une enuresie nocturne urine dans son lit alors qu'il est endormi et n'est generalement pas reveille par le fait d'etre mouille. La forme la plus frequente est l'enuresie nocturne monosymptomatique, ce qui signifie qu'il n'y a pas de symptomes cliniques dans la journee. L'enuresie est un syndrome hereditaire resultant de trois facteurs : la polyurie nocturne, une capacite vesicale fonctionnelle reduite et un trouble de l'eveil. C'est la pathologie chronique de l'enfant la plus frequente dans les pays occidentaux. L'interrogatoire elimine les troubles mictionnels diurnes et precise les conditions de l'enuresie. L'examen clinique elimine une vessie neurologique ou une malformation. Les examens complementaires sont inutiles. Le traitement repose sur les alarmes et/ou la desmopressine. Il est reserve aux enfants et aux familles demandeurs. Le suivi pendant et a l'arret du traitement est un element essentiel du succes qui reste inconstant.
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- 2006
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13. Chirurgie cœlioscopique chez l'enfant
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G. Podevin, P. Buisson, M.-D. Leclair, Y. Heloury, C. Laplace, and Corinne Lejus
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Cardiorespiratory fitness ,medicine.disease ,Urological surgery ,Neonatal surgery ,Surgery ,Bowel obstruction ,Pediatrics, Perinatology and Child Health ,Medicine ,Robotic surgery ,business ,Laparoscopy - Abstract
In the last two decades, laparoscopy surgery has been progressively adopted to children. Cardiorespiratory changes induced have been understood and controlled. Abdominal and urological surgery have widely benefited from this technique. Immediate postoperative period is simpler. The risk of small bowel obstruction by bands and adhesions is limited. Nevertheless, laparoscopy is not indicated for all pathologies. In neonatal surgery, more studies are necessary. Maybe the future is robotic surgery.
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- 2005
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14. Appendicite et péritonite appendiculaire de l'enfant
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G. Podevin, M.-D. Leclair, M. Barussaud, and Y. Heloury
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Gynecology ,medicine.medical_specialty ,business.industry ,Pediatrics, Perinatology and Child Health ,medicine ,business ,Intraperitoneal abscess - Abstract
Resume L'appendicectomie est la premiere intervention digestive chez l'enfant, mais malgre sa frequence il reste parfois difficile de faire le diagnostic formel d'appendicite ou de peritonite appendiculaire. De plus, la morbidite de cette affection est loin d'etre negligeable. Le diagnostic repose essentiellement sur l'examen clinique et des dosages biologiques simples (numeration formule sanguine et proteine C-reactive), en les repetant si necessaire. L'echographie et le scanner sont reserves aux doutes diagnostiques. Une fois le diagnostic fait, le traitement de reference est l'appendicectomie, par laparotomie ou par laparoscopie, associee a une antibiotherapie adaptee a la gravite de l'infection. Les appendicites, en particulier si elles sont perforees, peuvent se compliquer d'abces de paroi ou d'abces intraperitoneaux que l'on traite par un traitement antibiotique eventuellement associe a un drainage chirurgical ou percutane.
- Published
- 2005
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15. Apendicitis y peritonitis apendicular en el niño
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G. Podevin, M. Barussaud, M.-D. Leclair, and Y. Heloury
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Physics ,Humanities - Abstract
La apendicectomia es la primera intervencion digestiva en el nino. Sin embargo, a pesar de su frecuencia, en ocasiones resulta dificil establecer el diagnostico formal de apendicitis o de peritonitis apendicular. Ademas, la morbilidad por esta afeccion es relativamente importante. El diagnostico se basa esencialmente en la exploracion fisica y en pruebas de laboratorio sencillas (hemograma y proteina C reactiva), que se repiten si es necesario. La ecografia y la tomografia computarizada se reservan para las dudas diagnosticas. Una vez establecido el diagnostico, el tratamiento de referencia es la apendicectomia, mediante laparotomia o laparoscopia, asociada a antibioticoterapia adecuada a la gravedad de la infeccion. Las apendicitis, sobre todo si se perforan, pueden complicarse con abscesos de pared o abscesos intraperitoneales, que se tratan con antibioticoterapia eventualmente asociada a drenaje quirurgico o percutaneo.
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- 2005
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16. Enuresis del niño
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L. Lenormand, Carmen Capito, C. Laplace, M.-D. Leclair, Y. Heloury, and G. Podevin
- Abstract
La enuresis se define como una miccion activa y completa que ocurre en un momento o en un lugar inapropiado, o socialmente inaceptable (nino de mas de 5 anos). El nino que padece enuresis nocturna orina en su cama mientras duerme y no suele despertarse por el hecho de estar mojado. La forma mas frecuente es la enuresis nocturna monosintomatica, lo que significa que no existen sintomas clinicos durante el dia. Esta afeccion es un sindrome hereditario que resulta de tres factores: la poliuria nocturna, una capacidad vesical funcional reducida y un trastorno del sueno. Es la enfermedad cronica del nino mas frecuente en los paises occidentales. El interrogatorio descarta los trastornos miccionales diurnos y concreta las condiciones de la enuresis. El examen clinico elimina una vejiga neurologica o una malformacion. Las pruebas complementarias resultan inutiles. El tratamiento se fundamenta en las alarmas y/o la desmopresina, y se reserva a aquellos ninos y familias que lo solicitan. El seguimiento durante el tratamiento y al cese del mismo constituye un elemento basico del exito, que permanece inconstante.
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- 2005
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17. [Does prenatal diagnosis modify neonatal management and early outcome of children with esophageal atresia type III?]
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C, Garabedian, R, Sfeir, C, Langlois, A, Bonnard, N, Khen-Dunlop, T, Gelas, L, Michaud, F, Auber, C, Piolat, J-L, Lemelle, V, Fouquet, É, Habonima, F, Becmeur, M-L, Polimerol, A, Breton, T, Petit, G, Podevin, F, Lavrand, H, Allal, M, Lopez, F, Elbaz, T, Merrot, J-L, Michel, P, Buisson, E, Sapin, P, Delagausie, C, Pelatan, J, Gaudin, D, Weil, P, de Vries, O, Jaby, H, Lardy, D, Aubert, C, Borderon, L, Fourcade, S, Geiss, J, Breaud, M, Pouzac, A, Echaieb, C, Laplace, F, Gottrand, and V, Houfflin-Debarge
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Treatment Outcome ,Pregnancy ,Prenatal Diagnosis ,Age Factors ,Infant, Newborn ,Humans ,Female ,Prospective Studies ,Esophageal Atresia - Abstract
Evaluate neonatal management and outcome of neonates with either a prenatal or a post-natal diagnosis of EA type III.Population-based study using data from the French National Register for EA from 2008 to 2010. We compared children with prenatal versus post-natal diagnosis in regards to prenatal, maternal and neonatal characteristics. We define a composite variable of morbidity (anastomotic esophageal leaks, recurrent fistula, stenosis) and mortality at 1 year.Four hundred and eight live births with EA type III were recorded with a prenatal diagnosis rate of 18.1%. Transfer after birth was lower in prenatal subset (32.4% versus 81.5%, P0.001). Delay between birth and first intervention was not significantly different. Defect size (2cm vs 1.4cm, P0.001), gastrostomy (21.6% versus 8.7%, P0.001) and length in neonatal unit care were higher in prenatal subset (47.9 days versus 33.6 days, P0.001). The composite variables were higher in prenatal diagnosis subset (38.7% vs 26.1%, P=0.044).Despite the excellent survival rate of EA, cases with antenatal detection have a higher morbidity related to the EA type (longer gap). Even if it does not modify neonatal management and 1-year outcome, prenatal diagnosis allows antenatal parental counseling and avoids post-natal transfer.
- Published
- 2014
18. Les problèmes digestifs et le polyhandicap chez l'enfant
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Y. Heloury, G. Podevin, M.-D. Leclair, and Carmen Capito
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Gynecology ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Public health ,Pediatrics, Perinatology and Child Health ,Nissen operation ,medicine ,business ,Gastrostomy - Published
- 2006
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19. Cure des sténoses hypertrophiques du pylore: intérêt des incisions périombilicales
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G Podevin
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Pediatrics, Perinatology and Child Health - Abstract
La cure chirurgicale de la stenose hypertrophique du pylore, debutee au debut de ce siecle, est actuellement une intervention de routine avec un taux de morbidite faible. L'innovation de ces dernieres annees a porte sur l'amelioration du prejudice esthetique causee par l'incision classique au niveau de l'hypocondre droit. L'abord periombilical recemment decrit permet un acces facile du pylore et diminue considerablement les sequelles cicatricielles de la voie classique. Dans une etude comparative portant sur pres de 240 patients, aucune difference n'a ete notee concernant differents facteurs de morbidite tels que les perforations muqueuses peroperatoires, les vomissements, les infections parietales, les eventrations, ou les recidives postoperatoires, entre l'incision dans l'hypocondre droit et l'approche periombilicale. Cette nouvelle voie d'abord permet donc de rendre cette intervention pleinement efficace, tant sur le plan fonctionnel qu'esthetique, et facilite l'oubli par les parents de cet incident de la vie de leur jeune nourrisson qu'est la stenose hypertrophique du pylore.
- Published
- 1997
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20. Stratégie diagnostique postnatale des uropathies malformatives dépistées avant la naissance
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D Barret, G Podevin, M Marechaud, G Levard, and F Girault
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Gynecology ,medicine.medical_specialty ,business.industry ,Medical screening ,Pediatrics, Perinatology and Child Health ,Medicine ,business ,Predictive value - Abstract
Resume L'experience croissante des equipes de diagnostic antenatal permet de depister des anomalies de plus en plus discretes de l'appareil urinaire. Ainsi, un grand nombre de dilatations pyeliques est detecte sans que l'on puisse en affirmer le caractere pathologique. Patients et methodes. — Lors d'une etude retrospective de 78 patients, nous avons determine la valeur predictive positive (VPP) des signes echographiques antenatals d'uropathies malformatives. Resultats. — Cette VPP etait de 27.3 % lorsqu'il s'agissait d'une dilatation pyelique isolee. Elle etait de 100 % s'il s'y associait une dilatation des calices. Le diametre anteroposterieur du pyelon mesure lors du troisieme trimestre de la grossesse peut predire la gravite de l'atteinte renale apres la naissance, puisqu'il etait de 6.7 ± 2.15 mm pour le groupe des dilatations pyeliques postnatales non pathologiques, significativement inferieur aux 13.4 ± 3 mm du groupe des syndromes de jonction pyelo-ureterale de stade I et aux 17 ± 9 mm des autres unites renales pathologiques. L'echographie antenatale a en revanche une mauvaise sensibilite pour la detection du reflux vesico-ureteral, quatre reflux primitifs sur 14 ayant ete depistes en l'absence d'anomalie echographique antenatale homolaterale. Conclusion. — Nous proposons une strategic diagnostique qui tient compte de ces resultats de la morbidite et du cout des differents examens. Une exploration urologique est effectuee devant une dilatation des cavites renales superieure a 10 mm. Si l'echographie de controle apres la naissance montre une dilatation pyelique isolee inferieure a ce seuil, seule une surveillance clinique est prescrite, en signalant aux parents la possibilite d'un reflux vesico-ureteral et done la necessite d'un examen cytobacteriologique des urines devant toute fievre inexpliquee.
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- 1997
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21. [Psychopathology of the misuse of Subutex®: The Popeye syndrome]
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J, Békaert and G, Podevin
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Adult ,Male ,Cognitive Behavioral Therapy ,Dose-Response Relationship, Drug ,Psychopathology ,Comorbidity ,Syndrome ,Opioid-Related Disorders ,Skin Diseases ,Buprenorphine ,Conflict, Psychological ,Alcoholism ,Forearm ,Cross-Sectional Studies ,Recurrence ,Chronic Disease ,Hand Deformities, Acquired ,Opiate Substitution Treatment ,Edema ,Humans ,France ,Substance Abuse, Intravenous ,Prescription Drug Misuse ,Defense Mechanisms - Abstract
High dose buprenorphine (HDB), commonly known as Subutex(®), is nowadays largely prescribed as a replacement therapy for major opiate dependence. Its sublingual administration allows a decrease in the withdrawal syndrome accompanying opiate abuse cessation. Over the past few decades, epidemiological data on people on replacement therapy have emphasized an increase in the misuse of Subutex(®) and more specifically intravenous injections of HDB. These growing practices pave the way to major physical consequences or even death. Several studies have highlighted the infectious, vascular, venous and arterial (pseudo-aneurysm) complications stemming from this habit. Among the possible vascular complications, we can notice the presence of abscess, venous thrombosis, phlegmons, skin necrosis, cellulite, and profound and superficial thrombophlebitis at injection sites. These can evolve into chronic edemas of the tips and subcutaneous nodules. The Popeye syndrome is one of the possible complications of this misuse. This syndrome is characterized by the swelling of both sides of the forearms and hands. These edemas tend to become persistent and to be paired with tissue changes such as skin thickening. Besides, the increase in the hands volume can occur bilaterally or sometimes in an asymmetrical way, accentuated on the hand of the non-dominant limb. This syndrome does not decrease, or just a little, after the stoppage of injections. It can have a psychological, social, psychopathological and esthetic impact.In this article, we will focus on the clinical case of a 43-year-old man, who is hospitalized in an addictology unit for massive injections of HDB. This patient suffers from a Popeye syndrome as well as from an alcoholic dependence.Following the description of psychopathological disorders, our analysis will originate from a clarification relative to the specificities of the practice of intravenous HDB injection to better sharpen the understanding of these misuses in their psychopathological and clinical aspects. We will discuss some proposals for interventions aiming at taking better care of the people suffering from a drug addiction characterized by the injection of HDB replacement therapy.Adam requested an admission in an addictology ward for treatment of a self-medication by Subutex started 4 years ago. A certain awkwardness can be perceived when he lays his highly damaged and marked hands on the desk. His upper limbs, thus on display, have tripled in volume: this indicates the presence of a Popeye syndrome, consequence of repeated Subutex injections. These observations lead us to question the function and the sense of this injection behavior in the mental economy, as this repeated behavior engages the body specifically. This bruised body, marked with repeated injection holes has become a place of inscription, of representation that shows the impossibility to access other ways of expression. In this sense, taking action is becoming an act of speech. Within this speech, we can notice the existence of a profound state of uneasiness. To put up with the painful feeling of inner emptiness that is calling for a necessary filling, aiming at re-establishing a frail balance, Adam appeals to repeated injections. However, when the tortured body signifies its incapacity to receive an ultimate injection, thus showing its limits and the destruction it is undergoing, it is no longer possible to resort to Subutex injections. As a consequence, Adam came up with the idea of quitting. The withdrawal was initiated by himself and not coupled with medical care. It has led him to feel a gap, beyond the physical uneasiness. Adam has tried to fill in this unbearable feeling of empty body with tobacco, alcohol and food. The body, highly mobilized, translates the presence of a physical conflict where a massive mental anxiety is expressed in a hidden way. During the interview, Adam also addressed the repetitive familial pattern and the transgeneration effects. He seems to be fully aware of these.Several perspectives can be addressed as part of Adam's treatment and especially cognitive-behavioral therapies as they could prove to be of a certain interest. The aim of this therapy would thus be to assess the motivation for change in order to begin a psychotherapeutic work based on personal adherence to the cessation of this misuse. This could be set up in parallel with an anxiety management work.A better understanding and an extensive knowledge of the possible complications linked to the misuse of HDB seems necessary to sensitize and better inform people who suffer from high-risk behaviors and also to enable a more adapted care.
- Published
- 2013
22. [Anorectal malformations]
- Author
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C, Cretolle, V, Rousseau, H, Lottmann, S, Irtan, S, Lortat-Jacob, I, Alova, J L, Michel, Y, Aigrain, G, Podevin, P A, Lehur, and S, Sarnacki
- Subjects
Postoperative Care ,Infant, Newborn ,Rectum ,Anal Canal ,Prognosis ,Severity of Illness Index ,Anorectal Malformations ,Anus, Imperforate ,Treatment Outcome ,Prevalence ,Quality of Life ,Humans ,Rectal Fistula ,France ,Digestive System Surgical Procedures - Abstract
Anorectal malformations (ARM) are the result of an abnormal development of the terminal part of the digestive tract interesting anus and/or rectum that occur early between the sixth and tenth week of embryonic development. They carry a malformation spectrum of severity depending on the level of disruption of the anorectal canal and of the associated caudal malformations (sacrum and spine). ARM are associated in over half the cases with other malformations that can be integrated in some cases in known syndromes. If surgical treatment to restore anatomy as normal as possible is indispensable, post-operative care is essential for these patients whose defecation mechanisms are altered, to reach if not continence, at least a socially acceptable cleanliness.
- Published
- 2013
23. [Impact of the national rare disease plan on the management of anorectal malformations]
- Author
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C, Cretolle, G, Podevin, V, Rousseau, H, Lottmann, I, Alova, S, Irtan, S, Lortat-Jacob, A, Cazenave, G, Disnan, P, Slamani, C, Tonatello, H, Kahia-Aoul, Y, Aigrain, P A, Lehur, and S, Sarnacki
- Subjects
Anus, Imperforate ,Male ,Health Planning ,Rare Diseases ,Rectum ,Anal Canal ,Humans ,Abnormalities, Multiple ,Female ,France ,Anorectal Malformations ,Fecal Incontinence - Published
- 2013
24. Update on laparoscopic surgery: surgeon's point of view
- Author
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Corinne Lejus, Leclair, G. Podevin, and Y. Héloury
- Subjects
Laparoscopic surgery ,medicine.medical_specialty ,Education, Medical ,Point (typography) ,medicine.diagnostic_test ,business.industry ,General surgery ,medicine.medical_treatment ,Robotics ,Pediatrics ,Laparoscopes ,Surgery ,Anesthesiology and Pain Medicine ,Pediatrics, Perinatology and Child Health ,medicine ,Humans ,Laparoscopy ,business - Published
- 2004
- Full Text
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25. Redo Hirschsprung : un challenge
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G. Podevin
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business.industry ,Pediatrics, Perinatology and Child Health ,Medicine ,business - Published
- 2014
- Full Text
- View/download PDF
26. Chirurgia laparoscopica epatica
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Y. Héloury, M. Catti, G. Podevin, A. Rinaldi, and M. D. Leclair
- Abstract
A differenza di altre aree in chirurgia pediatrica, la resezione epatica mininvasiva non ha ottenuto ampia popolarita. Le ragioni di cio sono presumibilmente correlate al timore di complicanze intraoperatorie quali sanguinamento o embolismo gassoso. Comunque, i miglioramenti in tecnologia laparoscopica e l’incrementata esperienza nella chirurgia degli adulti a partire dalla prima descrizione nel 1992 ora autorizza le resezioni laparoscopiche epatiche e la ricostruzione del tratto biliare in pazienti pediatrici selezionati.
- Published
- 2010
- Full Text
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27. [Complicated acute appendicitis in children: laparotomy versus laparoscopy]
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G, Podevin, M-L, Barussaud, M-D, Leclair, and Y, Heloury
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Laparotomy ,Treatment Outcome ,Appendectomy ,Humans ,Laparoscopy ,Appendicitis ,Child - Published
- 2008
28. [Is the bronchial atresia prenatal diagnosis possible?]
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A, Mechoulan, G, Podevin, A, Paumier, H-J, Philippe, F, Le Mouel, C, Le Vaillant, M-P, Quéré, M, Joubert, and N, Winer
- Subjects
Adult ,Male ,Pregnancy ,Prenatal Diagnosis ,Infant, Newborn ,Pregnancy Outcome ,Humans ,Bronchi ,Female ,Respiratory System Abnormalities ,Ultrasonography, Prenatal - Abstract
Bronchial atresia is a rare congenital malformation of the lung. The main-stem segmental or lobar bronchus fails to construct normally, which can lead to accumulation of mucus within the distal bronchi or lung hyperinflation of the obstructed lobe. The prenatal diagnosis is rare and difficult. We report two cases of fetuses who presented pathological examination of the lung on the ultrasonography, at 22 weeks of gestation, suspect of prenatal bronchial atresia diagnosis. We analysed this malformation through a literature review in order to discuss differential diagnosis to be evoked, as well as appropriate perinatal management.
- Published
- 2007
29. Coloproctologie pédiatrique : avancées récentes Conclusion
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G. Meurette and G. Podevin
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medicine.medical_specialty ,business.industry ,General surgery ,Gastroenterology ,Internal Medicine ,Medicine ,business ,Colorectal surgery - Published
- 2015
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30. [Neurologically impaired children and digestive problems]
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G, Podevin, C, Capito, M D, Leclair, and Y, Heloury
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Adolescent ,Fundoplication ,Infant ,Gastric Acidity Determination ,Injections, Intramuscular ,Protein-Energy Malnutrition ,Disabled Children ,Enteral Nutrition ,Treatment Outcome ,Child, Preschool ,Gastroscopy ,Gastroesophageal Reflux ,Humans ,Brain Damage, Chronic ,France ,Prospective Studies ,Botulinum Toxins, Type A ,Child ,Follow-Up Studies - Published
- 2006
31. [Laparoscopic surgery in children]
- Author
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P, Buisson, M D, Leclair, G, Podevin, C, Laplace, C, Lejus, and Y, Heloury
- Subjects
Postoperative Care ,Postoperative Complications ,Abdomen ,Infant, Newborn ,Humans ,Urologic Surgical Procedures ,Laparoscopy ,Child ,Risk Assessment - Abstract
In the last two decades, laparoscopy surgery has been progressively adopted to children. Cardiorespiratory changes induced have been understood and controlled. Abdominal and urological surgery have widely benefited from this technique. Immediate postoperative period is simpler. The risk of small bowel obstruction by bands and adhesions is limited. Nevertheless, laparoscopy is not indicated for all pathologies. In neonatal surgery, more studies are necessary. Maybe the future is robotic surgery.
- Published
- 2004
32. [Staghorn lithiasis in an infant related to mineral water high in calcium]
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J P, Saulnier, G, Podevin, M, Berthier, G, Levard, and D, Oriot
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Male ,Kidney Calculi ,Water Supply ,Calcinosis ,Humans ,Infant ,Calcium ,Mineral Waters ,Vitamin D - Abstract
Staghorn lithiases in the infant are rare. We report a staghorn lithiasis related to high calcium intake due to the exclusive use of the mineral water Hépar.In an eight-month-old infant, an abdominal film performed for repeated urinary symptoms showed a right-sided staghorn lithiasis. Past history revealed that his diet had contained as high as four times the recommended daily intake for calcium (1,750 mg) related to the exclusive use of Hépar mineral water. The latter had been discontinued one month prior to admission. Excessive doses of vitamin D (1,480 U/day) were given at this time. Blood tests were normal. Treatment combined surgical removal of the stone by right pyelolithotomy, and three extracorporeal lithotrity courses. A postoperative infection had a simple course after antibiotics.This staghorn lithiasis is the second case report to complications associated with long-term exclusive intake of Hépar mineral water in an infant. It has been likely favored by excessive doses of vitamin D. It emphasizes the danger of the exclusive use of high-calcium mineral water.
- Published
- 2001
33. [Post-natal diagnostic strategy of urinary tract malformations detected by prenatal screening]
- Author
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G, Podevin, G, Levard, M, Marechaud, F, Girault, and D, Barret
- Subjects
Male ,Vesico-Ureteral Reflux ,Pregnancy ,Infant, Newborn ,Humans ,Female ,Kidney Pelvis ,Syndrome ,Ureter ,Urinary Tract ,Ultrasonography, Prenatal ,Dilatation, Pathologic ,Retrospective Studies - Abstract
The increasing experience with prenatal ultrasonographic diagnosis allows detection of more and more mild urinary tract anomalies. Thus, the clinical significance of many pyelectasis detected before birth is not known.From a retrospective study of 78 patients, we determined the positive predictive value (PPV) of prenatal ultrasound findings for urinary tract malformations.This PPV was 27.3% when the prenatal pelvic dilatation was isolated, but grew up to 100% if a caliceal dilatation was associated. Renal pelvic diameter in the third trimester of pregnancy could predict the degree of post-natal renal impairment, as pelvic size was 6.7 +/- 2.15 mm for the post-natal pyelectasis group, significatively smaller than 13.4 +/- 3 mm in the ureteropelvic junction obstruction group (grade 1) and than 17 +/- 9 mm in other pathological renal units. On the other hand, antenatal ultrasound had a bad sensibility for vesico-ureteral reflux detection, four primary reflux among 14 being detected without homolateral antenatal ultrasound anomaly.According these results, we propose a post-natal diagnostic strategy. Urological explorations are performed when the prenatal renal pelvic diameter is larger than 10 mm. If the postnatal ultrasound shows an isolated pyelectasis below this level, a clinical follow-up is advised, the parents being informed of the possibility of vesico-ureteral reflux and of the necessity to perform a cytobacteriological exam of urines in case of unexplained fever.
- Published
- 1997
34. Congenital neoplasm of the clitoris
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G, Levard, J, Podevin, P, Levillain, and G, Podevin
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Vulvar Neoplasms ,Infant, Newborn ,Humans ,Female ,Clitoris - Published
- 1997
35. Registre national de l’atrésie de l’œsophage : résultats 2008
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R. Sfeir, L. Michaud, A. Bonnard, T. Gelas, N. Khen-Dunlop, F. Auber, F. Becmeur, A. Breton, G. Podevin, F. Lavrand, F. Gottrand, M. Morineau, T. Petit, F. Sabiani, V. Fouquet, E. Habonimana, H. Allal, C. Jacquier, J.-L. Lemelle, J.-L. Michel, M.-L. Poli-Mero, P. Buisson, H. Lardy, M. Lopez, D. Aubert, P. De Lagausie, P. de Vries, J. Gaudin, C. Borderon, A. Echaieb, F. Elbaz, L. Fourcarde, O. Jaby, E. Sapin, M. Arnould-Pouzac, J. Breaud, S. Geiss, C. Laplac, C. Pelatan, D. Weil, and F. Guéguin
- Subjects
Pediatrics, Perinatology and Child Health - Published
- 2011
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- View/download PDF
36. SFCP-015 – Urologie – Néphrectomie partielle par laparoscopie rétropéritonéale chez l’enfant
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I. Vidal, Y. Heloury, M.-D. Leclair, G. Podevin, and E. Supply
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Pediatrics, Perinatology and Child Health - Abstract
Objectifs Alors que la laparoscopie est devenue une technique de reference dans de nombreuses indications en chirurgie pediatrique, il existe peu de grandes series de nephrectomie partielles dans la litterature. Nous rapportons notre experience de cette technique. Patients et Methodes Etude retrospective de 48 nephrectomies partielles (36 nephrectomies polaires superieures (NPS) et 12 polaires inferieures (NPI) chez l’enfant, realisees consecutivement de 1993 a 2007. L’âge median au moment de l’intervention etait de 8,6 mois (5,7 mois pour les NPS, 17 mois pour les NPI). L’enfant etait place en decubitus lateral dans 31 cas, et en decubitus ventral pour les 17 derniers cas. Resultats La duree mediane d’intervention etait de 120 minutes (extr 71-215). Dix conversions (21 %) ont ete necessaires, essentiellement au debut de l’experience (1/20 dans les 20 derniers cas, vs 8/20 pour les 20 premiers). Pour les NPI, 3/4 ont ete converties pour des difficultes lors de la section du parenchyme, a l’epoque ou elle etait realisee a la bipolaire. Six NPS ont ete converties, a chaque fois chez des petits nourrissons, d’âge median 3,25 mois (1,5-8), pour des difficultes d’exposition et de visualisation de la vascularisation du pole inferieur restant, difficultes majorees par une dilatation ureterale importante (>15mm, n = 3) ou un pneumoperitoine (n = 2). Le suivi median est de 14 mois (4-125). Nous avons observe 1 cas de perte fonctionnelle du pole restant (cas n °4). Conclusions La nephrectomie partielle par laparoscopie retroperitoneale reste faisable quelque soit l’âge. Il s’agit d’une intervention techniquement difficile, en particulier chez des petits nourrissons avec une voie excretrice tres dilatee. Le risque d’alteration fonctionnelle definitive du pyelon restant doit etre connu, et doit imposer la conversion lorsqu’une comprehension parfaite de l’anatomie vasculaire n’est pas certaine.
- Published
- 2008
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- View/download PDF
37. Biais de perception des risques chez les femmes anxieuses
- Author
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F. Sgard, Stéphane Rusinek, and G. Podevin
- Subjects
Psychiatry and Mental health ,Clinical Psychology ,Neuropsychology and Physiological Psychology - Published
- 2005
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38. Restructuration par habituation aux schémas salutogènes
- Author
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G. Podevin and S. Rusinek
- Subjects
Psychiatry and Mental health ,Clinical Psychology ,Neuropsychology and Physiological Psychology - Published
- 2005
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39. Découverte précoce néonatale d’un pleuropneumoblastome par le diagnostic prénatal : revue de la littérature
- Author
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M. Joubert, N. Winer, A. Mechoulan, F. Leclair, M.-P. Quere, M. Yvinec, H.-J. Philippe, and G. Podevin
- Subjects
Reproductive Medicine ,Obstetrics and Gynecology ,General Medicine - Published
- 2004
- Full Text
- View/download PDF
40. Mise au point de la thérapie génique du déficit en OTC, à l'aide d'un rétrovirus recombinant, sur le modèle de la souris spfash
- Author
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G Podevin
- Subjects
Pediatrics, Perinatology and Child Health - Published
- 1995
- Full Text
- View/download PDF
41. Technical Problems and Complications of a Transanal Pull-Through for Hirschsprung's Disease.
- Author
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G. Podevin
- Published
- 2006
42. Prenatal diagnosis of sacrococcygeal teratoma with constitutional partial monosomy 7q/trisomy 2p.
- Author
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C. Le Caignec, N. Winer, M. Boceno, C. Delnatte, G. Podevin, J. M. Liet, M. P. Quere, M. Joubert, and J. M. Rival
- Abstract
We report the prenatal diagnosis of a fetus with sacrococcygeal teratoma and facial dysmorphism attributed to a constitutional terminal deletion of chromosome 7q and partial trisomy of chromosome 2p likely resulting from a de novo balanced translocation. The cytogenetic abnormality was diagnosed prenatally after sonographic detection of teratoma and confirmed on peripheral blood cells at birth. The newborn died of post-operative complications at seven days of age. FISH analysis demonstrated haploinsufficiency of HLXB9, a gene identified in the triad of a presacral mass (teratoma or anterior meningocele), sacral agenesis, and anorectal malformation, which constitutes the Currarino syndrome. Despite the absence of other features of the triad, the teratoma observed in the fetus we describe might represent a partial form of Currarino syndrome. Copyright © 2003 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
- Published
- 2003
- Full Text
- View/download PDF
43. Quels usages de la proximité par les FONGECIF ?
- Author
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Moysan-Louazel, Anne, Podevin, Gérard, Centre d'études et de recherches sur les qualifications (CEREQ), ministère de l'Emploi, cohésion sociale et logement-Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Centre de recherche en économie et management (CREM), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), S. Ghaffari, G. Podevin, Louise-Rose, Naïla, and Normandie Université (NU)-Normandie Université (NU)-Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
territorialisation ,FONGECIF ,[SHS.ECO] Humanities and Social Sciences/Economics and Finance ,[SHS.ECO]Humanities and Social Sciences/Economics and Finance ,congé individuel de formation - Published
- 2008
44. Congenital Diaphragmatic Eventration: Should we Maintain Surgical Treatment? A Retrospective Multicentric Cohort Study.
- Author
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Heng L, Alzahrani K, Montalva L, Podevin G, and Schmitt F
- Abstract
Background: The aims of this study were to describe the characteristics of children with congenital diaphragmatic eventration (CDE) and compare the outcomes of surgical and conservative treatment of pediatric CDE in France., Methods: Retrospective study on cohort data conducted in 22 paediatric surgery departments, including patients less than 16 years of age diagnosed with CDE between 2010 and 2021. Patients with surgical or conservative treatment were compared., Results: 139 patients were included, with a median age of 8 [1-16] months. CDE occurred in boys in 68.3% and was right-sided in 66.7% of the cases. Indication for treatment depended essentially on respiratory symptoms and level of the diaphragmatic dome. The initial treatment was a surgical, with a diaphragmatic plication, in 87 cases (62%) and conservative, consisting of clinical follow-up in 52 children (38%). Of the latter, 25 children underwent surgery secondarily. Intra- and early post-operative complications occurred in 32 children (29%) and eventration recurrence in 8 children (7%). With a median follow-up of 28 months, the median level of diaphragmatic dome improved from the 6th to the 9th back rib, and the rate of respiratory symptoms decreased from 64% to 14% in the overall cohort of patients., Conclusions: Diaphragmatic plication is effective in symptomatic patients with a dome level above the 6th posterior rib, but is associated with a 29% complication rate and 7% of recurrence., Clinicaltrials: NCT04862494, April 28, 2021., Level of Evidence: level III treatment study., Competing Interests: Conflicts of interest None., (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Published
- 2024
- Full Text
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45. Different Fecal Microbiota in Hirschsprung's Patients With and Without Associated Enterocolitis.
- Author
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Arnaud AP, Cousin I, Schmitt F, Petit T, Parmentier B, Levard G, Podevin G, Guinot A, DeNapoli S, Hervieux E, Flaum V, De Vries P, Randuineau G, David-Le Gall S, Buffet-Bataillon S, and Boudry G
- Abstract
Background and Objectives: Patients with Hirschsprung's disease are at risk of developing Hirschsprung-associated enterocolitis, especially in the first 2 years of life. The pathophysiology of this inflammatory disease remains unclear, and intestinal dysbiosis has been proposed in the last decade. The primary objective of this study was to evaluate in a large cohort if Hirschsprung-associated enterocolitis was associated with alterations of fecal bacterial composition compared with HD without enterocolitis in different age groups., Methods: We analyzed the fecal microbiota structure of 103 Hirschsprung patients from 3 months to 16 years of age, all of whom had completed definitive surgery for rectosigmoid Hirschsprung. 16S rRNA gene sequencing allowed us to compare the microbiota composition between Hirschsprung's disease patients with (HAEC group) or without enterocolitis (HD group) in different age groups (0-2, 2-6, 6-12, and 12-16 years)., Results: Richness and diversity increased with age group but did not differ between HD and HAEC patients, irrespective of the age group. Relative abundance of Actinobacteria was lower in HAEC than in HD patients under 2 years of age (-66%, P = 0.045). Multivariate analysis by linear models (MaAsLin) considering sex, medications, birth mode, breast-feeding, and the Bristol stool scale, as well as surgery parameters, highlighted Flavonifractor plautii and Eggerthella lenta , as well as Ruminococcus gnavus group, as positively associated with Hirschsprung-associated enterocolitis in the 0-2 years age group., Conclusion: Hirschsprung-associated enterocolitis was associated with features of intestinal dysbiosis in infants (0-2 years) but not in older patients. This could explain the highest rate of enterocolitis in this age group., Clinical Trial Registration: https://clinicaltrials.gov/ct2/show/NCT02857205, MICROPRUNG, NCT02857205, 02/08/2016., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Arnaud, Cousin, Schmitt, Petit, Parmentier, Levard, Podevin, Guinot, DeNapoli, Hervieux, Flaum, De Vries, Randuineau, David-Le Gall, Buffet-Bataillon and Boudry.)
- Published
- 2022
- Full Text
- View/download PDF
46. Long-Term Functional Outcomes of an Anorectal Malformation French National Cohort.
- Author
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Schmitt F, Scalabre A, Mure PY, Borrione C, Lemelle JL, Sharma D, De Napoli S, Irtan S, Levard G, Becmeur F, Buisson P, Fourcade L, Arnaud A, De Vries P, Branchereau S, Garignon C, Sauvat F, Kalfa N, Lardy H, Jochault-Ritz S, Sapin E, Coridon H, Margaryan M, Pouzac M, Carfagna L, Polimerol ML, Varlet F, Sarnacki S, Cretolle C, and Podevin G
- Subjects
- Adolescent, Adult, Anal Canal surgery, Child, Constipation complications, Constipation etiology, Cross-Sectional Studies, Defecation, Female, Humans, Male, Rectum surgery, Retrospective Studies, Young Adult, Anorectal Malformations complications, Anorectal Malformations epidemiology, Anorectal Malformations surgery
- Abstract
Objectives: The present study aimed to assess long-term functional outcomes of children with anorectal malformations (ARMs) across a network of expert centers in France., Methods: Retrospective cross-sectional study of patients ages 6-30 years that had been surgically treated for ARM. Patient and ARM characteristics (eg, level, surgical approach) and functional outcomes were assessed in the different age groups., Results: Among 367 patients, there were 155 females (42.2%) and 212 males (57.8%), 188 (51.2%) cases with, and 179 (48.8%) higher forms without, perineal fistula. Univariate and multivariate statistical analyses with logistic regression showed correlation between the level of the rectal blind pouch and voluntary bowel movements (odds ratio [OR] = 1.84 [1.31-2.57], P < 0.001), or soiling (OR = 1.72 [1.31-2.25], P < 0.001), which was also associated with the inability to discriminate between stool and gas (OR = 2.45 [1.28-4.67], P = 0.007) and the presence of constipation (OR = 2.97 [1.74-5.08], P < 0.001). Risk factors for constipation were sacral abnormalities [OR = 2.26 [1.23-4.25], P = 0.01) and surgical procedures without an abdominal approach (OR = 2.98 [1.29-6.87], P = 0.01). Only the holding of voluntary bowel movements and soiling rates improved with age., Conclusion: This cross-sectional study confirms a strong association between anatomical status and functional outcomes in patients surgically treated for ARM. It specifically highlights the need for long-term follow-up of all patients to help them with supportive care., Competing Interests: The authors report no conflicts of interest., (Copyright © 2022 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.)
- Published
- 2022
- Full Text
- View/download PDF
47. Lessons from a large nationwide cohort of 350 children with ovarian mature teratoma: A study in favor of ovarian-sparing surgery.
- Author
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Delehaye F, Sarnacki S, Orbach D, Cheikhelard A, Rouger J, Parienti JJ, Faure-Conter C, Hameury F, Dijoud F, Aubry E, Wacrenier A, Habonimana E, Duchesne C, Joseph S, Alliot H, Scalabre A, Chaussy Y, Podevin G, Croue A, Haraux E, Guibal MP, Pommepuy I, Ballouhey Q, Lavrand F, Peycelon M, Irtan S, Guerin F, Dariel A, Borionne C, Galmiche L, and Rod J
- Subjects
- Adolescent, Child, Female, Humans, Ovariectomy, Retrospective Studies, Ovarian Neoplasms pathology, Teratoma pathology
- Abstract
Background: Ovarian mature teratoma (OMT) is a common ovarian tumor found in the pediatric population. In 10%-20% of cases, OMT occurs as multiple synchronous or metachronous lesions on ipsi- or contralateral ovaries. Ovarian-sparing surgery (OSS) is recommended to preserve fertility, but total oophorectomy (TO) is still performed., Design: This study reviews the clinical data of patients with OMT, and analyzes risk factors for second events. A national retrospective review of girls under 18 years of age with OMTs was performed. Data on clinical features, imaging, laboratory studies, surgical reports, second events and their management were retrieved., Results: Overall, 350 children were included. Eighteen patients (5%) presented with a synchronous bilateral form at diagnosis. Surgery was performed by laparotomy (85%) and laparoscopy (15%). OSS and TO were performed in 59% and 41% of cases, respectively. Perioperative tumor rupture occurred in 23 cases, independently of the surgical approach. Twenty-nine second events occurred (8.3%) in a median time of 30.5 months from diagnosis (ipsilateral: eight cases including one malignant tumor; contralateral: 18 cases; both ovaries: three cases). A large palpable mass, bilateral forms, at diagnosis and perioperative rupture had a statistical impact on the risk of second event, whereas the type of surgery or approach did not., Conclusion: This study is a plea in favor of OSS as the first-choice treatment of OMT when possible. Close follow-up during the first 5 years is mandatory considering the risk of 8.3% of second events, especially in cases with risk factors., (© 2021 Wiley Periodicals LLC.)
- Published
- 2022
- Full Text
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48. Analysis of enteric nervous system and intestinal epithelial barrier to predict complications in Hirschsprung's disease.
- Author
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Dariel A, Grynberg L, Auger M, Lefèvre C, Durand T, Aubert P, Le Berre-Scoul C, Venara A, Suply E, Leclair MD, de Vries P, Levard G, Parmentier B, Podevin G, Schmitt F, Couvrat V, Irtan S, Hervieux E, Villemagne T, Lardy H, Capito C, Muller C, Sarnacki S, Mosnier JF, Galmiche L, Derkinderen P, Boudin H, Brochard C, and Neunlist M
- Subjects
- Child, Preschool, Diarrhea epidemiology, Diarrhea etiology, Diarrhea prevention & control, Enterocolitis etiology, Enterocolitis prevention & control, Follow-Up Studies, Ganglia physiopathology, Humans, Infant, Infant, Newborn, Intestinal Mucosa innervation, Pilot Projects, Postoperative Complications etiology, Postoperative Complications prevention & control, Prospective Studies, Time Factors, Enteric Nervous System physiopathology, Enterocolitis epidemiology, Hirschsprung Disease surgery, Intestinal Mucosa physiopathology, Postoperative Complications epidemiology
- Abstract
In Hirschsprung's disease (HSCR), postoperative course remains unpredictable. Our aim was to define predictive factors of the main postoperative complications: obstructive symptoms (OS) and Hirschsprung-associated enterocolitis (HAEC). In this prospective multicentre cohort study, samples of resected bowel were collected at time of surgery in 18 neonates with short-segment HSCR in tertiary care hospitals. OS and HAEC were noted during postoperative follow-up. We assessed the enteric nervous system and the intestinal epithelial barrier (IEB) in ganglionic segments by combining immunohistochemical, proteomic and transcriptomic approaches, with functional ex vivo analysis of motility and para/transcellular permeability. Ten HSCR patients presented postoperative complications (median follow-up 23.5 months): 6 OS, 4 HAEC (2 with OS), 2 diarrhoea (without OS/HAEC). Immunohistochemical analysis showed a significant 41% and 60% decrease in median number of nNOS-IR myenteric neurons per ganglion in HSCR with OS as compared to HSCR with HAEC/diarrhoea (without OS) and HSCR without complications (p = 0.0095; p = 0.002, respectively). Paracellular and transcellular permeability was significantly increased in HSCR with HAEC as compared to HSCR with OS/diarrhoea without HAEC (p = 0.016; p = 0.009) and HSCR without complications (p = 0.029; p = 0.017). This pilot study supports the hypothesis that modulating neuronal phenotype and enhancing IEB permeability may treat or prevent postoperative complications in HSCR.
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- 2020
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49. Persistent Soiling Affects Quality of Life in Children With Hirschsprung's Disease.
- Author
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Espeso L, Coutable A, Flaum V, Rebeuh J, Lavrand F, Podevin G, Lamireau T, Enaud R, and Talon I
- Subjects
- Adolescent, Child, Defecation, Follow-Up Studies, Humans, Quality of Life, Surveys and Questionnaires, Fecal Incontinence etiology, Hirschsprung Disease surgery
- Abstract
Objective: This multicentric study aimed to evaluate the quality of life (QOL) in children with Hirschsprung's disease (HD)., Methods: HD patients aged from 6 to 18 years and followed-up in 2 French pediatric surgery centers were included in this study. QOL was assessed using the HAQL questionnaires according to age (6-11 and 12-18), filled by patients and their parents (proxy reports) and correlated with initial disease characteristics, nutritional status, and functional score of Krickenbeck., Results: Sixty-three patients were included. The acquisition of satisfactory voluntary bowel movements was found in only 50% of the 6 to 11 years old and 68% of the teenagers. Seventy percentage of the children and 55% of teenagers had soiling issues. The overall HAQLproxy6--11 score was 528/700; best scores were found for "fecal continence" (94/100), "social functioning" (94/100), and "urinary continence" (92/100) whereas the worst scores were for "general well-being" (64/100) and "diurnal fecal continence" (58/100). The overall HAQLproxy12--16 score was 607/700; best scores were for "urinary continence" (96/100) and "social functioning" (93/100). In a multivariate analysis, soiling was the only factor significantly associated with low QOL (P = 0.03)., Conclusions: Soiling remains frequent in children operated on for HD and negatively affects their QOL. Assessment and treatment of soiling should be the priority for medical teams in the follow-up of these children.
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- 2020
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50. Predictors of the Performance of Early Antireflux Surgery in Esophageal Atresia.
- Author
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François B, Michaud L, Sfeir R, Bonnard A, Rousseau V, Blanc S, Gelas T, Boubnova J, Jacquier C, Irtan S, Breton A, Fouquet V, Guinot A, Lamireau T, Habounimana E, Schneider A, Elbaz F, Ranke A, Poli-Merol ML, Kalfa N, Dupont-Lucas C, Petit T, Michel JL, Buisson P, Lirussi-Borgnon J, Sapin E, Lardy H, Levard G, Parmentier B, Cremillieux C, Lopez M, Podevin G, Schmitt F, Borderon C, Jaby O, Pelatan C, De Vries P, Pouzac-Arnould M, Grosos C, Breaud J, Laplace C, Tolg C, Sika A, Auber F, Labreuche J, Duhamel A, and Gottrand F
- Subjects
- Anastomosis, Surgical adverse effects, Constriction, Pathologic, Esophageal Atresia classification, Female, France, Gastroesophageal Reflux surgery, Gastrostomy, Humans, Infant, Infant, Low Birth Weight, Infant, Newborn, Male, Multivariate Analysis, Nutritional Status, Registries, Esophageal Atresia surgery, Fundoplication
- Abstract
Objective: To identify predictors of and factors associated with the performance of antireflux surgery during the first year of life in children born with esophageal atresia., Study Design: All patients were included in a French registry for esophageal atresia. All 38 multidisciplinary French centers completed questionnaires about perinatal characteristics and one-year outcome for children born with esophageal atresia., Results: Of 835 infants with esophageal atresia born in France from 2010 to 2014, 682 patients, excluding those with long-gap esophageal atresia, were included. Three patients had type I, 669 had type III, and 10 had type IV esophageal atresia. Fifty-three children (7.8%) received fundoplication during the first year of life. The median age at the time of the end-to-end esophageal anastomosis was 1.1 day (range 0-15). Multivariate analysis identified three perioperative factors that predicted the need for early antireflux surgery: anastomotic tension (P = .004), associated malformations (P = .019), and low birth weight (P = .018). Six other factors, measured during the first year of life, were associated with the need for antireflux surgery: gastroesophageal reflux (P < .001), anastomotic stricture (P < .001), gastrostomy (P < .001), acute life-threatening event (P = .002), respiratory complications (P = .045), and poor nutritional status (P < .001)., Conclusions: Gastroesophageal reflux disease, low birth weight, poor nutrition, and surgical anastomosis difficulties predicted the performance of antireflux surgery in the first year of life in infants with esophageal atresia., (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Published
- 2019
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