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1. First demonstration of the use of crab cavities on hadron beams

Author: R. Calaga, A. Alekou, F. Antoniou, R. B. Appleby, L. Arnaudon, K. Artoos, G. Arduini, V. Baglin, S. Barriere, H. Bartosik, P. Baudrenghien, I. Ben-Zvi, T. Bohl, A. Boucherie, O. S. Brüning, K. Brodzinski, A. Butterworth, G. Burt, O. Capatina, S. Calvo, T. Capelli, M. Carlà, F. Carra, L. R. Carver, A. Castilla-Loeza, E. Daly, L. Dassa, J. Delayen, S. U. De Silva, A. Dexter, M. Garlasche, F. Gerigk, L. Giordanino, D. Glenat, M. Guinchard, A. Harrison, E. Jensen, C. Julie, T. Jones, F. Killing, A. Krawczyk, T. Levens, R. Leuxe, B. Lindstrom, Z. Li, A. MacEwen, A. Macpherson, P. Menendez, T. Mikkola, P. Minginette, J. Mitchell, E. Montesinos, G. Papotti, H. Park, C. Pasquino, S. Pattalwar, E. C. Pleite, T. Powers, B. Prochal, A. Ratti, L. Rossi, V. Rude, M. Therasse, R. Tomás, N. Stapley, I. Santillana, N. Shipman, J. Simonin, M. Sosin, J. Swieszek, N. Templeton, G. Vandoni, S. Verdú-Andrés, M. Wartak, C. Welsch, D. Wollman, Q. Wu, B. Xiao, E. Yamakawa, C. Zanoni, F. Zimmermann, and A. Zwozniak
Subjects: Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Many future particle colliders require beam crabbing to recover geometric luminosity loss from the nonzero crossing angle at the interaction point (IP). A first demonstration experiment of crabbing with hadron beams was successfully carried out with high energy protons. This breakthrough result is fundamental to achieve the physics goals of the high luminosity LHC (HL-LHC) and the future circular collider (FCC). The expected peak luminosity gain (related to collision rate) is 65% for HL-LHC and even greater for the FCC. Novel beam physics experiments with proton beams in CERN’s Super Proton Synchrotron (SPS) were performed to demonstrate several critical aspects for the operation of crab cavities in the future HL-LHC including transparency with a pair of cavities, a full characterization of the cavity impedance with high beam currents, controlled emittance growth from crab cavity induced rf noise.
Published: 2021
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2. Luminosity scans for beam diagnostics

Author: M. Hostettler, K. Fuchsberger, G. Papotti, Y. Papaphilippou, and T. Pieloni
Subjects: Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: A new type of fast luminosity separation scans (“emittance scans”) was introduced at the CERN Large Hadron Collider (LHC) in 2015. The scans were performed systematically in every fill with full-intensity beams in physics production conditions at the interaction point (IP) of the compact muon solenoid (CMS) experiment. They provide both transverse emittance and closed orbit measurements at a bunch-by-bunch level. The precise measurement of beam-beam closed orbit differences allowed a direct, quantitative observation of long-range beam-beam PACMAN effects, which agrees well with numerical simulations from an improved version of the TRAIN code.
Published: 2018
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3. The Challenge of Evaluating Response to Peptide Receptor Radionuclide Therapy in Gastroenteropancreatic Neuroendocrine Tumors: The Present and the Future

Author: Virginia Liberini, Martin W. Huellner, Serena Grimaldi, Monica Finessi, Philippe Thuillier, Alfredo Muni, Riccardo E. Pellerito, Mauro G. Papotti, Alessandro Piovesan, Emanuela Arvat, and Désirée Deandreis
Subjects: peptide receptor radionuclide therapy, PRRT, 68Ga-labeled somatostatin analogue, 18F-FDG, response assessment, RECIST, Medicine (General), R5-920
Abstract: The NETTER-1 study has proven peptide receptor radionuclide therapy (PRRT) to be one of the most effective therapeutic options for metastatic neuroendocrine tumors (NETs), improving progression-free survival and overall survival. However, PRRT response assessment is challenging and no consensus on methods and timing has yet been reached among experts in the field. This issue is owed to the suboptimal sensitivity and specificity of clinical biomarkers, limitations of morphological response criteria in slowly growing tumors and necrotic changes after therapy, a lack of standardized parameters and timing of functional imaging and the heterogeneity of PRRT protocols in the literature. The aim of this article is to review the most relevant current approaches for PRRT efficacy prediction and response assessment criteria in order to provide an overview of suitable tools for safe and efficacious PRRT.
Published: 2020
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4. Overview of the 2022 WHO Classification of Adrenal Cortical Tumors

Author: Ozgur Mete, Lori A. Erickson, C. Christofer Juhlin, Ronald R. de Krijger, Hironobu Sasano, Marco Volante, and Mauro G. Papotti
Subjects: Adult, Endocrinology, Diabetes and Metabolism, Adrenal Gland Neoplasms, World Health Organization, Adrenal incidentaloma, Pathology and Forensic Medicine, Adrenal cortical carcinoma, Endocrinology, Adrenocortical Carcinoma, Humans, Cushing syndrome, Child, WHO classification, Primary aldosteronism, IGF2, Primary bilateral macronodular adrenal cortical hyperplasia, General Medicine, Adrenal Cortex Neoplasms, Adrenal cortical hyperplasia, Reticulin algorithm, Lynch syndrome, Adrenal cortical adenoma, Adrenal cortical nodular disease, Biomarkers, Reticulin histochemistry, Virilization and feminization, Adrenocortical Adenoma
Abstract: The new WHO classification of adrenal cortical proliferations reflects translational advances in the fields of endocrine pathology, oncology and molecular biology. By adopting a question-answer framework, this review highlights advances in knowledge of histological features, ancillary studies, and associated genetic findings that increase the understanding of the adrenal cortex pathologies that are now reflected in the 2022 WHO classification. The pathological correlates of adrenal cortical proliferations include diffuse adrenal cortical hyperplasia, adrenal cortical nodular disease, adrenal cortical adenomas and adrenal cortical carcinomas. Understanding germline susceptibility and the clonal-neoplastic nature of individual adrenal cortical nodules in primary bilateral macronodular adrenal cortical disease, and recognition of the clonal-neoplastic nature of incidentally discovered non-functional subcentimeter benign adrenal cortical nodules has led to redefining the spectrum of adrenal cortical nodular disease. As a consequence, the most significant nomenclature change in the field of adrenal cortical pathology involves the refined classification of adrenal cortical nodular disease which now includes (a) sporadic nodular adrenocortical disease, (b) bilateral micronodular adrenal cortical disease, and (c) bilateral macronodular adrenal cortical disease (formerly known primary bilateral macronodular adrenal cortical hyperplasia). This group of clinicopathological entities are reflected in functional adrenal cortical pathologies. Aldosterone producing cortical lesions can be unifocal or multifocal, and may be bilateral with no imaging-detected nodule(s). Furthermore, not all grossly or radiologically identified adrenal cortical lesions may be the source of aldosterone excess. For this reason, the new WHO classification endorses the nomenclature of the HISTALDO classification which uses CYP11B2 immunohistochemistry to identify functional sites of aldosterone production to help predict the risk of bilateral disease in primary aldosteronism. Adrenal cortical carcinomas are subtyped based on their morphological features to include conventional, oncocytic, myxoid, and sarcomatoid subtypes. Although the classic histopathologic criteria for diagnosing adrenal cortical carcinomas have not changed, the 2022 WHO classification underscores the diagnostic and prognostic impact of angioinvasion (vascular invasion) in these tumors. Microscopic angioinvasion is defined as tumor cells invading through a vessel wall and forming a thrombus/fibrin-tumor complex or intravascular tumor cells admixed with platelet thrombus/fibrin. In addition to well-established Weiss and modified Weiss scoring systems, the new WHO classification also expands on the use of other multiparameter diagnostic algorithms (reticulin algorithm, Lin-Weiss-Bisceglia system, and Helsinki scoring system) to assist the workup of adrenal cortical neoplasms in adults. Accordingly, conventional carcinomas can be assessed using all multiparameter diagnostic schemes, whereas oncocytic neoplasms can be assessed using the Lin-Weiss-Bisceglia system, reticulin algorithm and Helsinki scoring system. Pediatric adrenal cortical neoplasms are assessed using the Wieneke system. Most adult adrenal cortical carcinomas show 5 mitoses per 10 mm
Published: 2022

5. First demonstration of the use of crab cavities on hadron beams

Author: Graeme Burt, T. Levens, Q. Wu, Antoine Boucherie, L.R. Carver, Silvia Verdú-Andrés, Niklas Templeton, E. Jensen, Carsten Welsch, A. Harrison, Pierre Minginette, A. MacEwen, B. Prochal, V. Rude, H. Bartosik, Michael Guinchard, M. Wartak, S. Barriere, A. Zwozniak, J. Swieszek, C. Julie, Ignacio Aviles Santillana, F. Gerigk, Jean Delayen, L. Giordanino, Amos Dexter, T. Mikkola, T. Bohl, L. Arnaudon, C. Zanoni, Ilan Ben-Zvi, Nicholas Shipman, James Mitchell, K Brodzinski, Shrikant Pattalwar, S.U. De Silva, B. Lindstrom, T. Powers, A. Castilla-Loeza, M. Carlà, S. Calvo, Frank Zimmermann, Rama Calaga, Alick Macpherson, Paula Freijedo Menendez, Alessandro Ratti, V. Baglin, Gianluigi Arduini, F. Killing, Federico Carra, J. Simonin, Raphael Leuxe, Philippe Baudrenghien, Edward Daly, D. Glenat, Niall Stapley, D. Wollman, E. Yamakawa, A. Butterworth, Kurt Artoos, Mateusz Sosin, Eric Montesinos, Z. Li, H. Park, Oliver Brüning, Binping Xiao, Rogelio Tomás, G. Vandoni, Thomas A. Jones, F. Antoniou, R. B. Appleby, M. Therasse, C. Pasquino, Marco Garlaschè, G. Papotti, E.C. Pleite, Ofelia Capatina, Teddy Capelli, Luca Dassa, A. Krawczyk, Leonardo Paolo Rossi, and A. Alekou
Subjects: Physics, Nuclear and High Energy Physics, Large Hadron Collider, Luminosity (scattering theory), Physics and Astronomy (miscellaneous), Interaction point, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, Crab cavity, Física, Surfaces and Interfaces, QC770-798, Future Circular Collider, Super Proton Synchrotron, Accelerators and Storage Rings, Nuclear physics, Energías Renovables, Nuclear and particle physics. Atomic energy. Radioactivity, Physics::Accelerator Physics, Thermal emittance, Beam (structure)
Abstract: Many future particle colliders require beam crabbing to recover geometric luminosity loss from the nonzero crossing angle at the interaction point (IP). A first demonstration experiment of crabbing with hadron beams was successfully carried out with high energy protons. This breakthrough result is fundamental to achieve the physics goals of the high luminosity LHC (HL-LHC) and the future circular collider (FCC). The expected peak luminosity gain (related to collision rate) is 65% for HL-LHC and even greater for the FCC. Novel beam physics experiments with proton beams in CERN’s Super Proton Synchrotron (SPS) were performed to demonstrate several critical aspects for the operation of crab cavities in the future HL-LHC including transparency with a pair of cavities, a full characterization of the cavity impedance with high beam currents, controlled emittance growth from crab cavity induced rf noise. This research is supported by the HL-LHC project, US Department of Energy and UK Science and Technology Council through HL-LHC-UK. The authors thank the members of HL-LHC WP4 (crab cavity) Collaboration and CERN departments for their invaluable contributions. A special acknowledgement to the CARE, EuCARD, and US-LHC Accelerator Research Program (LARP) for their important role in enabling this research during the R&D phase. We also acknowledge the contributions of KEKB and Niowave Inc. to the crab cavity R&D.
Published: 2021

6. Immunohistochemical typing of amyloid in fixed paraffin-embedded samples by an automatic procedure: Comparison with immunofluorescence data on fresh-frozen tissue

Author: Antonella Barreca, Emanuel Bottasso, Francesca Veneziano, Manuela Giarin, Alberto Nocifora, Nadia Martinetti, Angelo Attanasio, Luigi Biancone, Giulia Benevolo, Dario Roccatello, Paola Cassoni, Mauro G Papotti, and Amyloidosis Group of the 'Rete Interregionale Piemonte e Valle d’Aosta per le Malattie Rare'
Subjects: Male, Proteomics, Pathology, Physiology, Biopsy, Immunofluorescence, Fluorescent Antibody Technique, Biochemistry, Mass Spectrometry, Immune Physiology, 80 and over, Medicine and Health Sciences, Electron Microscopy, Aged, 80 and over, Microscopy, Immune System Proteins, Paraffin Embedding, Multidisciplinary, medicine.diagnostic_test, biology, Amyloidosis, Middle Aged, Clinical Laboratory Sciences, Clinical Laboratories, Immunohistochemistry, Medicine, Female, Antibody, Research Article, Adult, Amyloid, medicine.medical_specialty, Science, Immunology, Surgical and Invasive Medical Procedures, Amyloidogenic Proteins, Aged, Humans, Research and Analysis Methods, Antibodies, Signs and Symptoms, Diagnostic Medicine, medicine, Typing, Immunoassays, Immunohistochemistry Techniques, business.industry, Biology and Life Sciences, Proteins, Gold standard (test), medicine.disease, Histochemistry and Cytochemistry Techniques, Immunologic Techniques, Amyloid Proteins, biology.protein, Transmission Electron Microscopy, Clinical Medicine, business
Abstract: Amyloidosis comprises a spectrum of disorders characterized by the extracellular deposition of amorphous material, originating from an abnormal serum protein. The typing of amyloid into its many variants represents a pivotal step for a correct patient management. Several methods are currently used, including mass spectrometry, immunofluorescence, immunohistochemistry, and immunogold labeling. The aim of the present study was to investigate the accuracy and reliability of immunohistochemistry by means of a recently developed amyloid antibody panel applicable on fixed paraffin-embedded tissues in an automated platform. Patients with clinically and pathologically proven amyloidosis were divided into two cohorts: a pilot one, which included selected amyloidosis cases from 2009 to 2018, and a retrospective one (comprising all consecutive amyloidosis cases analyzed between November 2018 and May 2020). The above-referred panel of antibodies for amyloid classification was tested in all cases using an automated immunohistochemistry platform. When fresh-frozen material was available, immunofluorescence was also performed. Among 130 patients, a total of 143 samples from different organs was investigated. They corresponded to 51 patients from the pilot cohort and 79 ones from the retrospective cohort. In 82 cases (63%), fresh-frozen tissue was tested by immunofluorescence, serving to define amyloid subtype only in 30 of them (36.6%). On the contrary, the automated immunohistochemistry procedure using the above-referred new antibodies allowed to establish the amyloid type in all 130 cases (100%). These included: ALλ (n = 60, 46.2%), ATTR (n = 29, 22.3%), AA (n = 19, 14.6%), ALκ (n = 18, 13.8%), ALys (n = 2, 1.5%), and Aβ2M amyloidosis (n = 2, 1.5%). The present immunohistochemistry antibody panel represents a sensitive, reliable, fast, and low-cost method for amyloid typing. Since immunohistochemistry is available in most pathology laboratories, it may become the new gold standard for amyloidosis classification, either used alone or combined with mass spectrometry in selected cases.
Published: 2021

7. Monoclonal/polyclonal PAX-8, PTH and GATA3 immunohistochemistry in parathyroid lesions

Author: S, Altınay, B, Erözgür, A C, Dural, M, Volante, and M G, Papotti
Subjects: Adenoma, Adult, Aged, 80 and over, Male, Hyperplasia, Parathyroid Diseases, Thyroid Gland, Antibodies, Monoclonal, GATA3 Transcription Factor, Middle Aged, Hyperparathyroidism, Primary, Immunohistochemistry, Diagnosis, Differential, PAX8 Transcription Factor, Parathyroid Neoplasms, Parathyroid Hormone, Humans, Female, Aged
Abstract: Parathyroid gland (PG) is an endocrine organ which may display different immunohistochemical stainings with chief cells and oxyphilic cells in normal as well as hyperplasic/tumoral lesions.In this study, we aimed to identify the demographic properties and diagnostic value of the GATA3 antibody, which is a transcription factor in addition to PTH, and of PAX-8 (monoclonal and polyclonal) antibody.We have analyzed in detail the cellular components and staining intensities of 46 adenomas all of which contained parathyroid rims, 12 hyperplasia and 5 adjacent non-neoplastic thyroidectomy materials (63 patients, 114 tissues).While no staining was identified in the thyroid tissue, cytoplasmic PTH immunoreactivity was observed in all (100%) normal parathyroid tissues, rim of PGs and hyperplasia, and in 43/46 cases (93.4%) of adenomas. Adenoma and hyperplasia were less stained than normal PG (p 0.05). We detected GATA3 staining in all cases except for the thyroid (100%). Weak positivity (1+) was most apparent in adenoma cases (p 0.05). Monoclonal PAX-8 immunoreactivity was not identified in any normal parathyroid tissue and rim of PG but positive immunoreactivity was detected in 83.3% of hyperplasia cases (10/12), 84.8% of adenoma (39/46) and 100% of thyroid tissues (5/5) (p 0.05). However, polyclonal PAX-8 immunoreactivity was detected in one normal parathyroid tissue (1/5) and seven (7/46) rim of PGs. In cases of hyperplasia and adenoma, positive immunoreactivity was 75% (9/12) and 74% (34/46), respectively.In conclusion, we have observed that PTH and GATA3 constitute a much more reliable and sensitive marker for parathyroid and are stained less in adenomas. While monoclonal PAX-8 (MRQ-50) never stains normal parathyroid and rim of PGs, it may help in the differential diagnosis of proliferated parathyroid lesions as a considerably sensitive and relatively specific marker by staining hyperplasic parathyroid, adenomas and the thyroid.
Published: 2020

8. MD1271: Effect of low frequency noise on the evolution of the emittance and halo population

Author: M. Fitterer, Stancari, Giulio, A. Valishev, R. Bruce, W. Hoefle, M. Hostettler, S.P. Papadopoulou, G. Papotti, Papaphilippou, Yannis, D. Pellegrini, G. Trad, D. Valuch, Valentino, Gianluca, Wagner, Joschka, and C. Xu
Subjects: Physics::Accelerator Physics, Accelerators and Storage Rings
Abstract: For the High Luminosity upgrade the β* in IR1 and IR5 will be further reduced compared to the current LHC. As the β* decreases the β-functions in the inner triplet (IT) increase resulting in a higher sensitivity of the HL-LHC to ground motion in the IT region or to increases of the low frequency noise. Noise can in general lead to emittance growth and higher halo population and diffusion rate. However, it is usually assumed in the literature that only frequencies close to the betatron frequencies and sidebands have an effect on the emittance and tail population. To test this theory, an MD was carried out to observe if also low frequency noise can lead to emittance growth and stronger halo population and diffusion. This MD conducted on 24.08.2016 follows a previous MD on 05.11.2015/06.11.2015
Published: 2018

9. Effect of a resonant excitation on the evolution of the beam emittance and halo population

Author: M . Fitterer, Stancari, Giulio, A. Valishev, R. Bruce, S. P. Papadopoulou, G. Papotti, D. Pellegrini, Redaelli, Stefano, G. Trad, D. Valuch, Valentino, Gianluca, Wagner, Joschka, and C. Xu
Subjects: Physics::Accelerator Physics, Astrophysics::Cosmology and Extragalactic Astrophysics, Accelerators and Storage Rings
Abstract: Collimation with hollow electron beams or lenses (HEL) is currently one of the most promising concepts for active halo control in HL-LHC. In previous studies it has been shown that the halo can be efficiently removed with a hollow electron lens. Equally important as an efficient removal of the halo, is to demonstrate that the core stays unperturbed. In the case of an ideal hollow electron lens without bends, the field at the location of the beam core vanishes and the core remains unperturbed. In reality, the field at the beam core does not vanish entirely due to imperfections in the electron beam profile and the electron lens bends necessary to guide the electron in and out of the proton aperture. In particular, in the case of a pulsed operation of the electron lens the non-vanishing residual field induces noise on the proton beam. To identify the most sensitive pulsing patterns for the resonant mode and derive tolerances on the profile imperfections, a first MD was carried out of which the first results are presented in this note.
Published: 2017

10. 24 Hours Blood Pressure Pattern and Cerebrovascular Damage in Essential Hypertension

Author: Francesco Tosello, A. Viola, C. Modica, Silvia Monticone, Franco Rabbia, G. Papotti, G. Leotta, Cristina Paglieri, E. Saglio, E. Testa, Corrado Magnino, M. Mulone, and Franco Veglio
Subjects: Blood pressure control, medicine.medical_specialty, Pharmacotherapy, business.industry, Emergency medicine, Internal Medicine, Medicine, Cardiology and Cardiovascular Medicine, business
Published: 2007
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11. Role of Trained Nurses in the Blood Pressure Control of Treated Essential Hypertensive Patients

Author: G Leotta, F Rabbia, C Modica, E Testa, S Monticone, E Saglio, C Magnino, A Viola, F Tosello, G Papotti, C Paglieri, and F Veglio
Subjects: Blood pressure, Ambulatory blood pressure, Pharmacotherapy, business.industry, Anesthesia, Internal Medicine, Physical activity, Medicine, Cardiology and Cardiovascular Medicine, business
Published: 2007
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12. ‘Framingham Score’ and ‘Progetto Cuore’: Comparison Between Cardiovascular Risk Score

Author: A. Viola, Silvia Monticone, L. Movio, Francesco Tosello, Alberto Milan, G. Papotti, Paolo Mulatero, Franco Veglio, M. I. De Andres, Franco Rabbia, and E. Saglio
Subjects: medicine.medical_specialty, CUORE, Framingham Risk Score, Pharmacotherapy, business.industry, Internal medicine, Internal Medicine, Cardiology, medicine, Cardiology and Cardiovascular Medicine, business
Published: 2007
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13. Hypertension in Obstructive Sleep Apnoea

Author: Andrea Verhovez, Renata Carra, G. Papotti, Franco Veglio, Paolo Mulatero, Franco Rabbia, and Sara Del Colle
Subjects: medicine.medical_specialty, business.industry, Epidemiology, Internal medicine, Cardiology, Medicine, business, Cardiology and Cardiovascular Medicine, Sleep in non-human animals
Published: 2005
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14. CMS technical design report, volume II: Physics performance

Author: G. L. BAYATIAN, S. CHATRCHYAN, G. HMAYAKYAN, A. M. SIRUNYAN, W. ADAM, T. BERGAUER, M. DRAGICEVIC, J. ERO, M. FRIEDL, R. FRUEHWIRTH, V. GHETE, P. GLASER, J. HRUBEC, M. JEITLER, M. KRAMMER, I. MAGRANS, I. MIKULEC, W. MITAROFF, T. NOEBAUER, M. PERNICKA, P. PORTH, H. ROHRINGER, J. STRAUSS, A. TAUROK, W. WALTENBERGER, G. WALZEL, E. WIDL, C. E. WULZ, A. FEDOROV, M. KORZHIK, O. MISSEVITCH, R. ZUYEUSKI, V. CHEKHOVSKY, O. DVORNIKOV, I. EMELIANTCHIK, A. LITOMIN, V. MOSSOLOV, N. SHUMEIKO, A. SOLIN, R. STEFANOVITCH, J. SUAREZ GONZALEZ, A. TIKHONOV, V. PETROV, J. D'HONDT, S. DE WEIRDT, R. GOORENS, J. HEYNINCK, S. LOWETTE, S. TAVERNIER, W. VAN DONINCK, L. VAN LANCKER, O. BOUHALI, B. CLERBAUX, G. DE LENTDECKER, J. P. DEWULF, T. MAHMOUD, P. E. MARAGE, L. NEUKERMANS, V. SUNDARARAJAN, C. VANDER VELDE, P. VANLAER, J. WICKENS, S. ASSOUAK, J. L. BONNET, G. BRUNO, J. CAUDRON, B. DE CALLATAY, J. DE FAVEREAU DE JENERET, S. DE VISSCHER, C. DELAERE, P. DEMIN, D. FAVART, E. FELTRIN, E. FORTON, G. GREGOIRE, S. KALININ, D. KCIRA, T. KEUTGEN, G. LEIBENGUTH, V. LEMAITRE, Y. LIU, D. MICHOTTE, O. MILITARU, A. NINANE, S. OVYN, T. PIERZCHALA, K. PIOTRZKOWSKI, V. ROBERFROID, X. ROUBY, D. TEYSSIER, O. VAN DER AA, M. VANDER DONCKT, E. DAUBIE, P. HERQUET, A. MOLLET, A. ROMEYER, W. BEAUMONT, M. CARDACI, E. DE LANGHE, E. A. DE WOLF, L. RURUA, M. H. G. SOUZA, V. OGURI, A. SANTORO, A. SZNAJDER, M. VAZ, E. M. GREGORES, S. F. NOVAES, T. ANGUELOV, G. ANTCHEV, I. ATANASOV, J. DAMGOV, N. DARMENOV, L. DIMITROV, V. GENCHEV, P. IAYDJIEV, B. PANEV, S. PIPEROV, S. STOYKOVA, G. SULTANOV, I. VANKOV, A. DIMITROV, V. KOZHUHAROV, L. LITOV, M. MAKARIEV, A. MARINOV, E. MARINOVA, S. MARKOV, M. MATEEV, B. PAVLOV, P. PETKOV, C. SABEV, S. STOYNEV, Z. TOTEVA, V. VERGUILOV, G. M. CHEN, H. S. CHEN, K. L. HE, C. H. JIANG, W. G. LI, H. M. LIU, X. MENG, X. Y. SHEN, H. S. SUN, M. YANG, W. R. ZHAO, H. L. ZHUANG, Y. BAN, J. CAI, S. LIU, S. J. QIAN, Z. C. YANG, Y. L. YE, J. YING, J. WU, Z. P. ZHANG, N. GODINOVIC, I. PULJAK, I. SORIC, Z. ANTUNOVIC, M. DZELALIJA, K. MARASOVIC, V. BRIGLJEVIC, D. FERENCEK, K. KADIJA, S. MOROVIC, M. PLANINIC, C. NICOLAOU, A. PAPADAKIS, P. A. RAZIS, D. TSIAKKOURI, A. HEKTOR, M. KADASTIK, K. KANNIKE, E. LIPPMAA, M. MUNTEL, M. RAIDAL, P. A. AARNIO, S. CZELLAR, E. HAEGGSTROEM, A. HEIKKINEN, J. HARKONEN, V. KARIMAKI, R. KINNUNEN, T. LAMPEN, K. LASSILA PERINI, S. LEHTI, T. LINDEN, P. R. LUUKKA, S. MICHAL, T. MAENPAA, J. NYSTEN, M. STETTLER, E. TUOMINEN, J. TUOMINIEMI, L. WENDLAND, T. TUUVA, J. P. GUILLAUD, P. NEDELEC, D. SILLOU, M. ANFREVILLE, S. BEAUCERON, E. BOUGAMONT, P. BREDY, R. CHIPAUX, M. DEJARDIN, D. DENEGRI, J. DESCAMPS, B. FABBRO, J. L. FAURE, S. GANJOUR, F. X. GENTIT, A. GIVERNAUD, P. GRAS, G. HAMEL DE MONCHENAULT, P. JARRY, F. KIRCHER, M. C. LEMAIRE, B. LEVESY, E. LOCCI, J. P. LOTTIN, I. MANDJAVIDZE, M. MUR, E. PASQUETTO, A. PAYN, J. RANDER, J. M. REYMOND, F. RONDEAUX, A. ROSOWSKY, Z. H. SUN, P. VERRECCHIA, S. BAFFIONI, F. BEAUDETTE, M. BERCHER, U. BERTHON, S. BIMBOT, J. BOUROTTE, P. BUSSON, M. CERUTTI, D. CHAMONT, C. CHARLOT, C. COLLARD, D. DECOTIGNY, E. DELMEIRE, L. DOBRZYNSKI, A. M. GAILLAC, Y. GEEREBAERT, J. GILLY, M. HAGUENAUER, A. KARAR, A. MATHIEU, G. MILLERET, P. MINE, P. PAGANINI, T. ROMANTEAU, I. SEMENIOUK, Y. SIROIS, J. D. BERST, J. M. BROM, F. DIDIERJEAN, F. DROUHIN, J. C. FONTAINE, U. GOERLACH, P. GRAEHLING, L. GROSS, L. HOUCHU, P. JUILLOT, A. LOUNIS, C. MAAZOUZI, D. MANGEOL, C. OLIVETTO, T. TODOROV, P. VAN HOVE, D. VINTACHE, M. AGERON, J. L. AGRAM, G. BAULIEU, M. BEDJIDIAN, J. BLAHA, A. BONNEVAUX, G. BOUDOUL, E. CHABANAT, C. COMBARET, D. CONTARDO, R. DELLA NEGRA, P. DEPASSE, T. DUPASQUIER, H. EL MAMOUNI, N. ESTRE, J. FAY, S. GASCON, N. GIRAUD, C. GIRERD, R. HAROUTUNIAN, J. C. IANIGRO, B. ILLE, M. LETHUILLIER, N. LUMB, H. MATHEZ, G. MAURELLI, L. MIRABITO, S. PERRIES, O. RAVAT, R. KVATADZE, V. ROINISHVILI, R. ADOLPHI, R. BRAUER, W. BRAUNSCHWEIG, H. ESSER, L. FELD, A. HEISTER, W. KARPINSKI, K. KLEIN, C. KUKULIES, J. OLZEM, A. 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ALEXANDER, D. CASSEL, K. ECKLUND, B. HELTSLEY, C.D. JONES, V. KUZNETSOV, J.R. PATTERSON, A. RYD, J. THOM, P. WITTICH, C.P. BEETZ, G. CIRINO, V. PODRASKY, C. SANZENI, D. WINN, S. ABDULLIN, M.A. AFAQ, M. ALBROW, J. AMUNDSON, G. APOLLINARI, M. ATAC, W. BADGETT, J.A. BAKKEN, B. BALDIN, L.A.T. BAUERDICK, A. BAUMBAUGH, U. BAUR, P.C. BHAT, F. BORCHERDING, K. BURKETT, J.N. BUTLER, H. CHEUNG, I. CHURIN, S. CIHANGIR, M. DEMARTEAU, D.P. EARTLY, J.E. ELIAS, V.D. ELVIRA, I. FISK, J. FREEMAN, P. GARTUNG, F.J.M. GEURTS, D.A. GLENZINSKI, E. GOTTSCHALK, G. GRAHAM, D. GREEN, G.M. GUGLIELMO, Y. GUO, O. GUTSCHE, A. HAHN, J. HANLON, S. HANSEN, R.M. HARRIS, T. HESSELROTH, S.L. HOLM, B. HOLZMAN, S. IQBAL, E. JAMES, M. JOHNSON, U. JOSHI, B. KLIMA, J. KOWALKOWSKI, T. KRAMER, S. KWAN, E. LA VALLIE, M. LARWILL, S. LOS, L. LUEKING, G. LUKHANIN, S. LUSIN, K. MAESHIMA, P. MCBRIDE, S.J. MURRAY, V. O'DELL, M. PATERNO, J. PATRICK, D. PETRAVICK, R. PORDES, O. PROKOFYEV, V. RASMISLOVICH, N. RATNIKOVA, A. RONZHIN, V. SEKHRI, E. SEXTON-KENNEDY, T. SHAW, D. SKOW, R.P. SMITH, W.J. SPALDING, L. SPIEGEL, M. STAVRIANAKOU, G. STIEHR, I. SUZUKI, P. TAN, W. TANENBAUM, S. TKACZYK, S. VESELI, R. VIDAL, H. WENZEL, J. WHITMORE, W.J. WOMERSLEY, W.M. WU, Y. WU, A. YAGIL, J. YARBA, J.C. YUN, D. ACOSTA, P. AVERY, V. BARASHKO, P. BARTALINI, D. BOURILKOV, R. CAVANAUGH, A. DROZDETSKIY, R.D. FIELD, Y. FU, L. GRAY, D. HOLMES, B.J. KIM, S. KLIMENKO, J. KONIGSBERG, A. KORYTOV, K. KOTOV, P. LEVCHENKO, A. MADORSKY, K. MATCHEV, GUENAKH MITSELMAKHER, Y. PAKHOTIN, C. PRESCOTT, P. RAMOND, J.L. RODRIGUEZ, M. SCHMITT, B. SCURLOCK, H. STOECK, J. YELTON, W. BOEGLIN, V. GAULTNEY, L. KRAMER, S. LINN, P. MARKOWITZ, G. MARTINEZ, B. RAUE, J. REINHOLD, A. ASKEW, M. BERTOLDI, W.G.D. DHARMARATNA, Y. GERSHTEIN, S. HAGOPIAN, V. HAGOPIAN, M. JENKINS, K.F. JOHNSON, H. PROSPER, H. WAHL, M. BAARMAND, L. BAKSAY, S. GURAGAIN, M. HOHLMANN, H. MERMERKAYA, R. RALICH, I. VODOPIYANOV, M.R. ADAMS, R.R. BETTS, C.E. GERBER, E. SHABALINA, C. SMITH, T. TEN, U. AKGUN, A.S. AYAN, A. COOPER, P. DEBBINS, F. DURU, M. FOUNTAIN, N. GEORGE, E. MCCLIMENT, J.P. MERLO, A. MESTVIRISHVILI, M.J. MILLER, C.R. NEWSOM, E. NORBECK, Y. ONEL, I. SCHMIDT, S. WANG, E.W. ANDERSON, O. ATRAMENTOV, J.M. HAUPTMAN, J. LAMSA, B.A. BARNETT, B. BLUMENFELD, C.Y. CHIEN, D.W. KIM, P. MAKSIMOVIC, S. SPANGLER, M. SWARTZ, P. BARINGER, A. BEAN, D. COPPAGE, O. GRACHOV, E.J. KIM, M. MURRAY, D. BANDURIN, T. BOLTON, A. KHANOV, Y. MARAVIN, D. ONOPRIENKO, F. RIZATDINOVA, R. SIDWELL, N. STANTON, E. VON TOERNE, D. BADEN, R. BARD, S.C. ENO, T. GRASSI, N.J. HADLEY, R.G. KELLOGG, S. KUNORI, F. RATNIKOV, A. SKUJA, R. ARCIDIACONO, M. BALLINTIJN, G. BAUER, P. HARRIS, I. KRAVCHENKO, C. LOIZIDES, S. NAHN, C. PAUS, S. PAVLON, C. ROLAND, G. ROLAND, K. SUMOROK, S. VAURYNOVICH, G. VERES, B. WYSLOUCH, D. BAILLEUX, S. CORUM, P. CUSHMAN, A. DE BENEDETTI, A. DOLGOPOLOV, R. EGELAND, G. FRANZONI, W.J. GILBERT, J. GRAHL, J. HAUPT, Y. KUBOTA, J. MANS, N. PEARSON, R. RUSACK, A. SINGOVSKY, L.M. CREMALDI, R. GODANG, R. KROEGER, D.A. SANDERS, D. SUMMERS, K. BLOOM, D.R. CLAES, A. DOMINGUEZ, M. EADS, C. LUNDSTEDT, S. MALIK, G.R. SNOW, A. SOBOL, I. IASHVILI, A. KHARCHILAVA, G. ALVERSON, E. BARBERIS, O. BOERIU, G. EULISSE, Y. MUSIENKO, S. MUZAFFAR, I. OSBORNE, S. REUCROFT, J. SWAIN, L. TAYLOR, L. TUURA, D. WOOD, B. GOBBI, M. KUBANTSEV, H. SCHELLMAN, E. SPENCER, M. VELASCO, B. BAUMBAUGH, N.M. CASON, M. HILDRETH, D.J. KARMGARD, N. MARINELLI, R. RUCHTI, J. WARCHOL, M. WAYNE, B. BYLSMA, L.S. DURKIN, J. GILMORE, J. GU, D. HERMAN, P. KILLEWALD, K. KNOBBE, T.Y. LING, P. ELMER, D. MARLOW, P. PIROUE, D. STICKLAND, C. TULLY, T. WILDISH, S. WYNHOFF, Z. XIE, A. APRESYAN, K. ARNDT, K. BANICZ, V.E. BARNES, G. BOLLA, D. BORTOLETTO, A. BUJAK, A.F. GARFINKEL, O. GONZALEZ LOPEZ, L. GUTAY, N. IPPOLITO, Y. KOZHEVNIKOV, A.T. LAASANEN, C. LIU, V. MAROUSSOV, P. MERKEL, D.H. MILLER, J. MIYAMOTO, N. NEUMEISTER, C. ROTT, A. ROY, A. SEDOV, I. SHIPSEY, N. PARASHAR, G. EPPLEY, S.J. LEE, J. LIU, M. MATVEEV, T. NUSSBAUM, B.P. PADLEY, J. ROBERTS, A. TUMANOV, P. YEPES, A. BODEK, H. BUDD, Y.S. CHUNG, P. DE BARBARO, R. DEMINA, R. EUSEBI, G. GINTHER, Y. GOTRA, A. HOCKER, U. HUSEMANN, S. KORJENEVSKI, W. SAKUMOTO, P. SLATTERY, P. TIPTON, M. ZIELINSKI, E. BARTZ, J. DOROSHENKO, E. HALKIADAKIS, P.F. JACQUES, M.S. KALELKAR, D. KHITS, A. LATH, A. MACPHERSON, L. PERERA, R. PLANO, K. ROSE, S. SCHNETZER, S. SOMALWAR, R. STONE, G. THOMSON, T.L. WATTS, N. AKCHURIN, K.W. CARRELL, K. GUMUS, C. JEONG, H. KIM, V. PAPADIMITRIOU, A. SILL, M. SPEZZIGA, E. WASHINGTON, R. WIGMANS, L. ZHANG, T. BAPTY, D. ENGH, W. JOHNS, T. KESKINPALA, E. LUIGGI LOPEZ, S. NEEMA, S. NORDSTROM, S. PATHAK, P. SHELDON, E.W. VAANDERING, M. WEBSTER, M.W. ARENTON, S. CONETTI, B. COX, R. HIROSKY, R. IMLAY, A. LEDOVSKOY, D. PHILLIPS, H. POWELL, M. RONQUEST, D. SMITH, Y.W. BAEK, J.N. BELLINGER, D. BRADLEY, D. CARLSMITH, I. CROTTY, S. DASU, F. FEYZI, T. GORSKI, M. GROTHE, W. HOGG, M. JAWORSKI, P. KLABBERS, A. LANARO, R. LOVELESS, M. MAGRANS DE ABRIL, D. REEDER, W.H. SMITH, D. WENMAN, G.S. ATOYAN, S. DHAWAN, V. ISSAKOV, H. NEAL, A. POBLAGUEV, M.E. ZELLER, and B.S. YULDASHEV
Subjects: High Energy Physics::Phenomenology, STANDARD MODEL, High Energy Physics::Experiment, EXTRA DIMENSIONS, LHC, SUPERSYMMETRY, HIGGS
Abstract: CMS is a general purpose experiment, designed to study the physics of pp collisions at 14 TeV at the Large Hadron Collider (LHC). It currently involves more than 2000 physicists from more than 150 institutes and 37 countries. The LHC will provide extraordinary opportunities for particle physics based on its unprecedented collision energy and luminosity when it begins operation in 2007. The principal aim of this report is to present the strategy of CMS to explore the rich physics programme offered by the LHC. This volume demonstrates the physics capability of the CMS experiment. The prime goals of CMS are to explore physics at the TeV scale and to study the mechanism of electroweak symmetry breaking—through the discovery of the Higgs particle or otherwise. To carry out this task, CMS must be prepared to search for new particles, such as the Higgs boson or supersymmetric partners of the Standard Model particles, from the start-up of the LHC since new physics at the TeV scale may manifest itself with modest data samples of the order of a few fb-1 or less. The analysis tools that have been developed are applied to study in great detail and with all the methodology of performing an analysis on CMS data specific benchmark processes upon which to gauge the performance of CMS. These processes cover several Higgs boson decay channels, the production and decay of new particles such as Z' and supersymmetric particles, Bs production and processes in heavy ion collisions. The simulation of these benchmark processes includes subtle effects such as possible detector miscalibration and misalignment. Besides these benchmark processes, the physics reach of CMS is studied for a large number of signatures arising in the Standard Model and also in theories beyond the Standard Model for integrated luminosities ranging from 1 fb-1 to 30 fb-1. The Standard Model processes include QCD, B-physics, diffraction, detailed studies of the top quark properties, and electroweak physics topics such as the W and Z0 boson properties. The production and decay of the Higgs particle is studied for many observable decays, and the precision with which the Higgs boson properties can be derived is determined. About ten different supersymmetry benchmark points are analysed using full simulation. The CMS discovery reach is evaluated in the SUSY parameter space covering a large variety of decay signatures. Furthermore, the discovery reach for a plethora of alternative models for new physics is explored, notably extra dimensions, new vector boson high mass states, little Higgs models, technicolour and others. Methods to discriminate between models have been investigated. This report is organized as follows. Chapter 1, the Introduction, describes the context of this document. Chapters 2–6 describe examples of full analyses, with photons, electrons, muons, jets, missing ET, B-mesons and τ's, and for quarkonia in heavy ion collisions. Chapters 7–15 describe the physics reach for Standard Model processes, Higgs discovery and searches for new physics beyond the Standard Model.
Published: 2007

15. [PP.01.15] ACCURACY OF HOME BLOOD PRESSURE MONITORING IN ARTERIAL HYPERTENSION DIAGNOSIS

Author: Michele Covella, C. Fulcheri, Franco Veglio, M. Pappaccogli, Franco Rabbia, E. Perlo, Chiara Bertello, S. Di Monaco, E. Berra, and G. Papotti
Subjects: medicine.medical_specialty, Blood pressure, Physiology, business.industry, Internal medicine, Continuous noninvasive arterial pressure, Internal Medicine, Cardiology, Medicine, Blood pressure monitoring, Hypertension diagnosis, Cardiology and Cardiovascular Medicine, business
Published: 2016
Full Text: View/download PDF

16. LHC STATUS AND PERFORMANCE IN 2011

Author: G. Papotti
Subjects: Physics, Particle physics, Large Hadron Collider
Published: 2012
Full Text: View/download PDF

17. Ventricular repolarization before and after treatment in patients with secondary hypertension due to renal-artery stenosis and primary aldosteronism

Author: Franco Veglio, Alberto Milan, Chiara Bertello, Valeria Milazzo, Franco Rabbia, Simona Maule, Paolo Mulatero, and G. Papotti
Subjects: Adult, Male, medicine.medical_specialty, hypertension, Refractory Period, Electrophysiological, Physiology, Heart Ventricles, medicine.medical_treatment, Secondary hypertension, Blood Pressure, White coat hypertension, Spironolactone, Renal Artery Obstruction, Essential hypertension, Renal artery stenosis, QT interval, Renovascular hypertension, Electrocardiography, Primary aldosteronism, QT, primary aldosteronism, Internal medicine, Angioplasty, Hyperaldosteronism, Internal Medicine, medicine, Humans, Aged, Mineralocorticoid Receptor Antagonists, Risk Management, business.industry, Adrenalectomy, Middle Aged, medicine.disease, Long QT Syndrome, Hypertension, Renovascular, Treatment Outcome, Cardiology, Female, Cardiology and Cardiovascular Medicine, business
Abstract: A prolonged QT interval is a risk factor for ischemic heart disease in hypertensive subjects. Patients with renal-artery stenosis and primary aldosteronism (PA) are at increased risk of cardiovascular events. The objective of the present study was to evaluate the QT interval in patients with renovascular hypertension (RV) and PA before and after treatment. A total of 24 patients with RV and 38 with PA were studied; 89 patients with essential hypertension (EH) served as control group. Corrected QT intervals (QTcH) were measured from a 12-lead ECG. Basal QTcH was longer in RV (429±30 ms) and PA (423±23 ms) compared with EH controls (407±18 ms; P0.001). The prevalence of QTcH440 ms was higher in RV (29%) and PA patients (29%) compared with EH controls (4%; P0.001). QTcH interval was evaluated after treatment in 19 RV and 15 PA patients. QTcH was reduced after renal-artery angioplasty in RV patients (419±14 ms; P=0.02), and after spironolactone or adrenalectomy in PA (403±12 ms; P=0.01). In conclusion, QT interval was prolonged in patients with RV and PA compared with controls with EH. After angioplasty of renal-artery stenosis in RV, and treatment with spironolactone or adrenalectomy in PA, the cardiovascular risk of such patients may be reduced by concomitant blood pressure lowering and QT duration shortening.
Published: 2011

18. Characteristics of the patients referred to a Hypertension Unit between 1989 and 2003

Author: G. Leotta, Paolo Mulatero, Franco Veglio, G. Papotti, Franco Rabbia, Antonella Canadè, and E. Testa
Subjects: Male, medicine.medical_specialty, hypertension, business.industry, Resistant hypertension, Blood Pressure, Middle Aged, Surgery, Blood pressure, Grade 1 Hypertension, Italy, Internal medicine, Prevalence, Internal Medicine, medicine, Humans, Female, business, Hospital Units, Antihypertensive Agents
Abstract: The level of blood pressure, the type of antihypertensive treatment and the prevalence of resistant hypertension at the first examination were evaluated in 6254 patients referred to a hospital Hypertension Unit from 1989 to 2003. From 1989-1993 to 1999-2003, we observed a reduced prevalence of grade 2 and grade 3 hypertension, and an increase in the prevalence of grade 1 hypertension, the proportion of treated subjects, the average number of antihypertensive drugs per patient and the prevalence of resistant hypertension.
Published: 2008

19. Orthostatic hypotension: evaluation and treatment

Author: Franco Veglio, E. Testa, Corrado Magnino, Simona Maule, D. Naso, and G. Papotti
Subjects: Fludrocortisone, Midodrine, Anti-Inflammatory Agents, Blood volume, Autonomic Nervous System, Hypotension, Orthostatic, Orthostatic vital signs, medicine, Animals, Humans, Pure autonomic failure, Stroke, Pharmacology, business.industry, Hematology, General Medicine, medicine.disease, Autonomic nervous system, Heart failure, Anesthesia, Molecular Medicine, Cardiology and Cardiovascular Medicine, business, Adrenergic alpha-Agonists, medicine.drug
Abstract: Orthostatic hypotension (OH) may be dependent upon various neurogenic and non-neurogenic disorders and conditions. Neurogenic causes include the main autonomic failure syndromes, primary (multiple system atrophy, pure autonomic failure, and autonomic failure associated with Parkinson's disease) and secondary (central nervous system diseases, peripheral neuropathies and systemic diseases). Non-neurogenic causes of OH include cardiac impairment, fluid and electrolyte loss, vasodilatation, and old age. A number of drugs may also cause OH, through their vasoactive action or by interfering with the autonomic nervous system. Symptoms of OH are debilitating, often confining patients to bed, and longitudinal studies have shown that OH increases the risk of stroke, myocardial ischemia and mortality. The therapeutic goal is to decrease the incidence and severity of postural symptoms, rather than restore normotension. In non-neurogenic OH, treatment of the underlying cause may be curative. In neurogenic OH a combination of non-pharmacological and pharmacological measures is often needed. Patient education and non-pharmacological measures represent the first step; among these interventions, fluid repletion and physical countermanoeuvres have been proven very effective. Pharmacological treatment comprises a number of agents acting on blood vessels, on blood volume or with other pressor mechanisms. The drugs most currently used are fludrocortisone and midodrine. Fludrocortisone expands the extravascular body fluid volume and improves alpha-adrenergic sensitivity. Midodrine is a peripheral, selective alpha1-adrenergic agonist that causes arterial and venous vasoconstriction. Despite the wide use of these drugs, multicentre, randomised and controlled studies for the treatment of OH are still scarce and limited to few agents and groups of patients. Pharmacological management of OH substantially improves the quality of life of patients, although it may be problematic. The development of supine hypertension and subsequent congestive heart failure should be avoided, especially in those patients with a pre-existing cardiovascular risk, such as in diabetes or ischemic heart disease.
Published: 2007

20. CMS physics technical design report, volume II: Physics performance

Author: G. Russo, R. Halsall, H. L. Zhuang, Stephan Linn, Stefanos Dris, J.F. Gunion, D. Delikaris, David Mark Raymond, Christophe Delaere, J. Caballero Bejar, Alex Kamenev, Victor Kim, Armando Lanaro, Sajjad Asghar, Vivek Sharma, P. Mereu, S. B. Kim, M. G. Albrow, Kostas Kloukinas, R. A. Kvatadze, Y. Velikzhanin, C. Mavrommatis, J. T. Rhee, M. Guerzoni, Robert M Harris, F. Romano, Daniele Spiga, Flera Rizatdinova, Dmitry Gorbunov, Giacomo Bruno, Laszlo Boldizsar, W. E. Johns, B. De Callatay, Pushpalatha C Bhat, M. Pioppi, Lawrence Sulak, L. J. Gutay, M. Hashemi, W. Badgett, A. Bartoloni, C. Y. Chien, E. Marinova, Daniel Robert Marlow, J. M. Barcala, C. Sabev, Roberto Sacchi, P. Bartalini, B. Panev, J. Reinhold, Yves Sirois, J. Ying, M. Demarteau, Alicia Calderon, Arno Heister, Lothar At Bauerdick, Marco Meschini, R. Wilkinson, Tejinder Virdee, Mirko Planinic, G. Martinelli, Y. Ershov, Piotr Traczyk, M. Ageron, Kirill Prokofiev, S. De Visscher, W. Bertl, Julia Thom, D. S. Bailey, N. Manna, Francesco Navarria, A. Karar, Pierre Ramond, Lucia Silvestris, R. Eichler, Neeti Parashar, S. Cucciarelli, R. Gokieli, Christopher George Tully, L. Masetti, I. Gonzalez Cabellero, Klaus Rabbertz, S. Zelepoukine, Sebastiano Albergo, A. Bonnevaux, P. Fabbricatore, Claudio Campagnari, V. Timciuc, O. Zorba, Igor Lokhtin, Ezio Maina, Colin Bernet, Nadia Pastrone, M. Galanti, K. Marasovic, Jim Kowalkowski, M. Zielinski, P. Aspell, Teppo Mäenpää, Pamela Klabbers, V. B. Francis, I. Diaz Merino, H. A. Sanchez Hernandez, Valery Zhukov, Christos Leonidopoulos, Gyorgy Bencze, Dimitri Bourilkov, Vassili Kachanov, Marina Passaseo, Patrick Slattery, J. Schümann, K. Cho, Hans-Christian Kaestli, Filip Moortgat, Francesca Nessi-Tedaldi, S. K. Lalwani, P. Trüb, D. Wenman, Aliaksandr Litomin, P. Siegrist, S. K. Oh, M. Kossov, A. Slav, Nicanor Colino, Z. Wlodarczyk, J. Amundson, H. Mathez, A. Papageorgiou, Pete Markowitz, J. Blocki, I. Soric, L. 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Geerebaert, Michele Arneodo, Steve Reucroft, Boaz Klima, Richard G Kellogg, Pavel Demin, G. Schwering, V. Papadimitriou, Daijin Kim, Paolo Vitulo, William J Spalding, Jay Roberts, I. Pal, N. Estre, L. Tauscher, Andras Laszlo, S. Spangler, Darien Wood, H. Suter, Ia Iashvili, W. Tanenbaum, Yury Ivanov, Andre Sznajder, F. Rondeaux, S. Y. Jung, Yuri Gershtein, Monoranjan Guchait, Brajesh C Choudhary, Paul David Luckey, M. Sani, D. Lanske, N. Ilina, Ian Shipsey, J. G. Shiu, Artur Kalinowski, Igor Emeliantchik, B. Heltsley, Robin Erbacher, Henryk Czyrkowski, L. Rurua, R. Beuselinck, Umesh Joshi, Irina Vardanyan, David B. Cline, M. Hansen, P. Bordalo, Ariella Cattai, G. Gomezo, J. A. Bakken, Jordan Nash, Sung Keun Park, E. Luiggi Lopez, M. Wensveen, R. Folch, E. Carrone, Cristina Riccardi, D. Krpic, S. Magni, Nicholas John Hadley, Karl Matthew Ecklund, M. Stettler, S. Vanini, Andrey Vorobyev, Matteo Risoldi, J. Bourotte, Kati Lassila-Perini, A. De Benedetti, M. Aldaya Martin, M. Duda, A. 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Filine, Pascal Paganini, A. Roy, N. Zamiatin, S. Paktinat Mehdiabadi, Vladimir Andreev, Aruna Nayak, I. Jimenez, Archana Sharma, Saptaparna Bhattacharya, Laird Kramer, Andrey Korytov, P. Chang, Eduardo De Moraes Gregores, John H. Wickens, Vladimir Korenkov, N. Magini, A. Moggi, I. Crotty, Jan Krolikowski, Duccio Abbaneo, V. Litvine, Elizabeth Locci, M. I. Asghar, A. Kapusi, Y. Zhang, C. Bloch, V. Sknar, Vadim Issakov, Giovanni Polese, Alexander Toropin, J. Nysten, E. Forton, Y. Liu, S. Wang, M. Jaworski, H. Foeth, Belforte, S., Cossutti, F., DELLA RICCA, Giuseppe, Gobbo, B., Penzo, A., Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Département d'Astrophysique, de physique des Particules, de physique Nucléaire et de l'Instrumentation Associée (DAPNIA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Département Recherches Subatomiques (DRS-IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), informatique, Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), CMS, Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National de Physique Nucléaire et de 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Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Bayatian, G, Chatrchyan, S, Hmayakyan, G, Sirunyan, A, Adam, W, Bergauer, T, Dragicevic, M, Ero, J, Friedl, M, Fruehwirth, R, Ghete, V, Glaser, P, Hrubec, J, Jeitler, M, Krammer, M, Magrans, I, Mikulec, I, Mitaroff, W, Noebauer, T, Pernicka, M, Porth, P, Rohringer, H, Strauss, J, Taurok, A, Waltenberger, W, Walzel, G, Widl, E, Wulz, C, Fedorov, A, Korzhik, M, Missevitch, O, Zuyeuski, R, Chekhovsky, V, Dvornikov, O, Emeliantchik, I, Litomin, A, Mossolov, V, Shumeiko, N, Solin, A, Stefanovitch, R, Gonzalez, J, Tikhonov, A, Petrov, V, D'Hondt, J, De Weirdt, S, 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Pimia, M, Pintus, R, Postema, H, Principe, R, Pelayo, J, Racz, A, Rehn, J, Reynaud, S, Risoldi, M, Moreira, P, Rolandi, G, Rosinsky, P, Rumerio, P, Sakulin, H, Samyn, D, Schilling, F, Schwick, C, Schafer, C, Segoni, I, Sharma, A, Siegrist, P, Sinanis, N, Sphicas, P, Spiropulu, M, Szoncso, F, Teller, O, Treille, D, Troska, J, Tsesmelis, E, Tsirigkas, D, Tsirou, A, Ungaro, D, Vasey, F, Acosta, M, Veillet, L, Vichoudis, P, Wertelaers, P, Wijnant, A, Wilhelmsson, M, Willers, I, Bertl, W, Deiters, K, Erdmann, W, Gabathuler, K, Heising, S, Horisberger, R, Ingram, Q, Kaestli, H, Kotlinski, D, Konig, S, Renker, D, Rohe, T, Spira, M, Betev, B, Davatz, G, Dissertori, G, Dittmar, M, Djambazov, L, Ehlers, J, Eichler, R, Faber, G, Freudenreich, K, Fuchs, J, Grab, C, Holzner, A, Ingenito, P, Langenegger, U, Lecomte, P, Leshev, G, Lister, A, Luckey, P, Lustermann, W, Maillefaud, J, Moortgat, F, Nardulli, A, Nessi Tedaldi, F, Pape, L, Pauss, F, Rykaczewski, H, Roser, U, Schinzel, D, Starodumov, A, Stockli, F, Suter, H, Tauscher, L, Trub, P, Von Gunten, H, Wensveen, M, Alagoz, E, Amsler, C, Chiochia, V, Hoermann, C, Prokofiev, K, Regenfus, C, Robmann, P, Speer, T, Steiner, S, Wilke, L, Blyth, S, Chang, Y, Chen, E, Go, A, Hung, C, Kuo, C, Lin, W, Chang, P, Chao, Y, Chen, K, Gao, Z, Hsiung, Y, Lei, Y, Schumann, J, Shiu, J, Ueno, K, Velikzhanin, Y, Yeh, P, Aydin, S, Bakirci, M, Cerci, S, Dumanoglu, I, Erturk, S, Esen, S, Eskut, E, Topaksu, A, Kurt, P, Ozkurt, H, Polatoz, A, Sogut, K, Topakli, H, Vergili, M, Yetkin, T, Onengut, G, Gamsizkan, H, Ozkan, C, Sekmen, S, Serin Zeyrek, M, Sever, R, Yazgan, E, Zeyrek, M, Cakir, A, Cankocak, K, Deliomeroglu, M, Demir, D, Dindar, K, Gulmez, E, Isiksal, E, Kaya, M, Kaya, O, Ozkorucuklu, S, Sonmez, N, Grinev, B, Lyubynskiy, V, Senchyshyn, V, Levchuk, L, Sorokin, P, Bailey, D, Barrass, T, Brooke, J, Croft, R, Cussans, D, Evans, D, Frazier, R, Grant, N, Heath, G, Heath, H, Huckvale, B, Lynch, C, Mackay, C, Metson, S, Newbold, D, Smith, V, Tapper, R, Baird, S, Bell, K, Brown, R, Cockerill, D, Coughlan, J, Flower, P, Francis, V, French, M, Greenhalgh, J, Halsall, R, Hill, J, Jones, L, Kennedy, B, Lintern, L, Lodge, A, Maddox, J, Morrissey, Q, Murray, P, Pearson, M, Quinton, S, Salisbury, J, Shah, A, Shepherd Themistocleous, C, Smith, B, Sproston, M, Stephenson, R, Taghavirad, S, Tomalin, I, Arteche, F, Bainbridge, R, Barber, G, Barrillon, P, Beuselinck, R, Blekman, F, Britton, D, Colling, D, Daskalakis, G, Dewhirst, G, Dris, S, Foudas, C, Fulcher, J, Greder, S, Hall, G, Jones, J, Leaver, J, Macevoy, B, Maroney, O, Nikitenko, A, Papageorgiou, A, Raymond, D, Ryan, M, Seez, C, Sharp, P, Takahashi, M, Timlin, C, Virdee, T, Wakefield, S, Wingham, M, Zabi, A, Zhang, Y, Zorba, O, Da Via, C, Goitom, I, Hobson, P, Kyberd, P, Munro, C, Nebrensky, J, Reid, I, Sharif, O, Taylor, R, Teodorescu, L, Watts, S, Yaselli, I, Hazen, E, Heering, A, Lazic, D, Machado, E, Osborne, D, Rohlf, J, Sulak, L, Rodriguez, F, Wu, S, Cutts, D, Hooper, R, Landsberg, G, Partridge, R, Vanini, S, Breedon, R, Case, M, Chertok, M, Conway, J, Cox, P, Erbacher, R, Gunion, J, Holbrook, B, Ko, W, Lander, R, Pellett, D, Smith, J, Soha, A, Tripathi, M, Vogt, R, Andreev, V, Arisaka, K, Cline, D, Cousins, R, Erhan, S, Felcini, M, Hauser, J, Ignatenko, M, Lisowski, B, Matlock, D, Matthey, C, Mohr, B, Mumford, J, Otwinowski, S, Rakness, G, Schlein, P, Shi, Y, Tucker, J, Valuev, V, Wallny, R, Wang, H, Yang, X, Zheng, Y, Clare, R, Fortin, D, Futyan, D, Gary, J, Giunta, M, Hanson, G, Jeng, G, Kao, S, Pasztor, G, Satpathy, A, Shen, B, Stringer, R, Sytnik, V, Wilken, R, Zer Zion, D, Branson, J, Dusinberre, E, Letts, J, Martin, T, Mojaver, M, Paar, H, Pi, H, Pieri, M, Rana, A, Sharma, V, White, A, Wurthwein, F, Affolder, A, Campagnari, C, Hill, C, Incandela, J, Kyre, S, Lamb, J, Richman, J, Stuart, D, White, D, Albert, J, Bornheim, A, Bunn, J, Chen, J, Denis, G, Galvez, P, Gataullin, M, Legrand, I, Litvine, V, Ma, Y, Nae, D, Newman, H, Ravot, S, Shevchenko, S, Singh, S, Steenberg, C, Su, X, Timciuc, V, Van Lingen, F, Veverka, J, Voicu, B, Weinstein, A, Wilkinson, R, Yang, Y, Zhang, L, Zhu, K, Zhu, R, Ferguson, T, Paulini, M, Russ, J, Terentyev, N, Vogel, H, Vorobiev, I, Cumalat, J, Ford, W, Johnson, D, Nauenberg, U, Stenson, K, Wagner, S, Alexander, J, Cassel, D, Ecklund, K, Heltsley, B, Jones, C, Kuznetsov, V, Patterson, J, Ryd, A, Thom, J, Wittich, P, Beetz, C, Cirino, G, Podrasky, V, Sanzeni, C, Winn, D, Abdullin, S, Afaq, M, Albrow, M, Amundson, J, Apollinari, G, Atac, M, Badgett, W, Bakken, J, Baldin, B, Bauerdick, L, Baumbaugh, A, Baur, U, Bhat, P, Borcherding, F, Burkett, K, Butler, J, Cheung, H, Churin, I, Cihangir, S, Demarteau, M, Eartly, D, Elias, J, Elvira, V, Fisk, I, Freeman, J, Gartung, P, Geurts, F, Glenzinski, D, Gottschalk, E, Graham, G, Green, D, Guglielmo, G, Guo, Y, Gutsche, O, Hahn, A, Hanlon, J, Hansen, S, Harris, R, Hesselroth, T, Holm, S, Holzman, B, Iqbal, S, James, E, Johnson, M, Joshi, U, Klima, B, Kowalkowski, J, Kramer, T, Kwan, S, La Vallie, E, Larwill, M, Los, S, Lueking, L, Lukhanin, G, Lusin, S, Maeshima, K, Mcbride, P, Murray, S, O'Dell, V, Paterno, M, Patrick, J, Petravick, D, Pordes, R, Prokofyev, O, Rasmislovich, V, Ratnikova, N, Ronzhin, A, Sekhri, V, Sexton Kennedy, E, Shaw, T, Skow, D, Smith, R, Spalding, W, Spiegel, L, Stavrianakou, M, Stiehr, G, Suzuki, I, Tan, P, Tanenbaum, W, Tkaczyk, S, Veseli, S, Vidal, R, Wenzel, H, Whitmore, J, Womersley, W, Wu, W, Wu, Y, Yagil, A, Yarba, J, Yun, J, Acosta, D, Avery, P, Barashko, V, Bartalini, P, Bourilkov, D, Cavanaugh, R, Drozdetskiy, A, Field, R, Fu, Y, Gray, L, Holmes, D, Kim, B, Klimenko, S, Konigsberg, J, Korytov, A, Kotov, K, Levchenko, P, Madorsky, A, Matchev, K, Mitselmakher, G, Pakhotin, Y, Prescott, C, Ramond, P, Rodriguez, J, Schmitt, M, Scurlock, B, Stoeck, H, Yelton, J, Boeglin, W, Gaultney, V, Kramer, L, Linn, S, Markowitz, P, Martinez, G, Raue, B, Reinhold, J, Askew, A, Bertoldi, M, Dharmaratna, W, Gershtein, Y, Hagopian, S, Hagopian, V, Jenkins, M, Johnson, K, Prosper, H, Wahl, H, Baarmand, M, Baksay, L, Guragain, S, Hohlmann, M, Mermerkaya, H, Ralich, R, Vodopiyanov, I, Adams, M, Betts, R, Gerber, C, Shabalina, E, Smith, C, Ten, T, Akgun, U, Ayan, A, Cooper, A, Debbins, P, Duru, F, Fountain, M, George, N, Mccliment, E, Merlo, J, Mestvirishvili, A, Miller, M, Newsom, C, Norbeck, E, Onel, Y, Schmidt, I, Wang, S, Anderson, E, Atramentov, O, Hauptman, J, Lamsa, J, Barnett, B, Blumenfeld, B, Chien, C, Maksimovic, P, Spangler, S, Swartz, M, Baringer, P, Bean, A, Coppage, D, Grachov, O, Kim, E, Murray, M, Bandurin, D, Bolton, T, Khanov, A, Maravin, Y, Onoprienko, D, Rizatdinova, F, Sidwell, R, Stanton, N, Von Toerne, E, Baden, D, Bard, R, Eno, S, Grassi, T, Hadley, N, Kellogg, R, Kunori, S, Ratnikov, F, Skuja, A, Arcidiacono, R, Ballintijn, M, Bauer, G, Harris, P, Kravchenko, I, Loizides, C, Nahn, S, Paus, C, Pavlon, S, Roland, C, Roland, G, Sumorok, K, Vaurynovich, S, Veres, G, Wyslouch, B, Bailleux, D, Corum, S, Cushman, P, De Benedetti, A, Dolgopolov, A, Egeland, R, Franzoni, G, Gilbert, W, Grahl, J, Haupt, J, Kubota, Y, Mans, J, Pearson, N, Rusack, R, Singovsky, A, Cremaldi, L, Godang, R, Kroeger, R, Sanders, D, Summers, D, Bloom, K, Claes, D, Dominguez, A, Eads, M, Lundstedt, C, Malik, S, Snow, G, Sobol, A, Iashvili, I, Kharchilava, A, Alverson, G, Barberis, E, Boeriu, O, Eulisse, G, Musienko, Y, Muzaffar, S, Osborne, I, Reucroft, S, Swain, J, Taylor, L, Tuura, L, Wood, D, Gobbi, B, Kubantsev, M, Schellman, H, Spencer, E, Velasco, M, Baumbaugh, B, Cason, N, Hildreth, M, Karmgard, D, Marinelli, N, Ruchti, R, Warchol, J, Wayne, M, Bylsma, B, Durkin, L, Gilmore, J, Gu, J, Herman, D, Killewald, P, Knobbe, K, Ling, T, Elmer, P, Marlow, D, Piroue, P, Stickland, D, Tully, C, Wildish, T, Wynhoff, S, Xie, Z, Apresyan, A, Arndt, K, Banicz, K, Barnes, V, Bolla, G, Bortoletto, D, Bujak, A, Garfinkel, A, Lopez, O, Gutay, L, Ippolito, N, Kozhevnikov, Y, Laasanen, A, Liu, C, Maroussov, V, Merkel, P, Miller, D, Miyamoto, J, Neumeister, N, Rott, C, Roy, A, Sedov, A, Shipsey, I, Parashar, N, Eppley, G, Lee, S, Liu, J, Matveev, M, Nussbaum, T, Padley, B, Roberts, J, Tumanov, A, Yepes, P, Bodek, A, Budd, H, Chung, Y, De Barbaro, P, Demina, R, Eusebi, R, Ginther, G, Gotra, Y, Hocker, A, Husemann, U, Korjenevski, S, Sakumoto, W, Slattery, P, Tipton, P, Zielinski, M, Bartz, E, Doroshenko, J, Halkiadakis, E, Jacques, P, Kalelkar, M, Khits, D, Lath, A, Macpherson, A, Perera, L, Plano, R, Rose, K, Schnetzer, S, Somalwar, S, Stone, R, Thomson, G, Watts, T, Akchurin, N, Carrell, K, Gumus, K, Jeong, C, Kim, H, Papadimitriou, V, Sill, A, Spezziga, M, Washington, E, Wigmans, R, Bapty, T, Engh, D, Johns, W, Keskinpala, T, Lopez, E, Neema, S, Nordstrom, S, Pathak, S, Sheldon, P, Vaandering, E, Webster, M, Arenton, M, Conetti, S, Cox, B, Hirosky, R, Imlay, R, Ledovskoy, A, Phillips, D, Powell, H, Ronquest, M, Smith, D, Baek, Y, Bellinger, J, Bradley, D, Carlsmith, D, Crotty, I, Dasu, S, Feyzi, F, Gorski, T, Grothe, M, Hogg, W, Jaworski, M, Klabbers, P, Lanaro, A, Loveless, R, De Abril, M, Reeder, D, Smith, W, Wenman, D, Atoyan, G, Dhawan, S, Issakov, V, Neal, H, Poblaguev, A, Zeller, M, Yuldashev, B, TR1918, Demir, Durmuş Ali, Izmir Institute of Technology. Physics, Çukurova Üniversitesi, Fen-Edebiyat Fakültesi, Fizik Bölümü, and Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Physics beyond the Standard Model, Large Hadron Collider (LHC), 01 natural sciences, 7. Clean energy, HIGGS-BOSON PRODUCTION, TO-LEADING-ORDER, PRODUCTION CROSS-SECTION, LARGE HADRON COLLIDER, SUPERSYMMETRIC STANDARD MODEL, ELECTROWEAK SYMMETRY-BREAKING, LARGE TRANSVERSE-MOMENTUM, B-C MESON, SUPERCONDUCTING SUPER COLLIDER, SOFTLY BROKEN SUPERSYMMETRY, Vector boson, Settore FIS/04 - Fisica Nucleare e Subnucleare, PARTICLE PHYSICS, CMS, Energy density, technical design report, CERN, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Physics, Large Hadron Collider, Settore FIS/01 - Fisica Sperimentale, Supersymmetry, Physics and Astronomy (all), Nuclear and High Energy Physics, FIS/01 - FISICA SPERIMENTALE, High-density QCD matter, Higgs boson, CMS, LHC, Physics, particles, Higgs, particle physics, detector, accelerator, Particle physics, Standard Model, Settore FIS/03 - Fisica della Materia, Nuclear physics, 0103 physical sciences, 010306 general physics, Settore MAT/07 - Fisica Matematica, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Little Higgs, pp, LHC, Higgs, supersymmetry, heavy ion, High Energy Physics::Experiment, CERN Large Hadron Collider (LHC), Parton momentum fraction, Minimal Supersymmetric Standard Model
Abstract: CMS is a general purpose experiment, designed to study the physics of pp collisions at 14 TeV at the Large Hadron Collider (LHC). It currently involves more than 2000 physicists from more than 150 institutes and 37 countries. The LHC will provide extraordinary opportunities for particle physics based on its unprecedented collision energy and luminosity when it begins operation in 2007. The principal aim of this report is to present the strategy of CMS to explore the rich physics programme offered by the LHC. This volume demonstrates the physics capability of the CMS experiment. The prime goals of CMS are to explore physics at the TeV scale and to study the mechanism of electroweak symmetry breaking - through the discovery of the Higgs particle or otherwise. To carry out this task, CMS must be prepared to search for new particles, such as the Higgs boson or supersymmetric partners of the Standard Model particles, from the start-up of the LHC since new physics at the TeV scale may manifest itself with modest data samples of the order of a few fb-1 or less. The analysis tools that have been developed are applied to study in great detail and with all the methodology of performing an analysis on CMS data specific benchmark processes upon which to gauge the performance of CMS. These processes cover several Higgs boson decay channels, the production and decay of new particles such as Z′ and supersymmetric particles, Bs production and processes in heavy ion collisions. The simulation of these benchmark processes includes subtle effects such as possible detector miscalibration and misalignment. Besides these benchmark processes, the physics reach of CMS is studied for a large number of signatures arising in the Standard Model and also in theories beyond the Standard Model for integrated luminosities ranging from 1 fb-1 to 30 fb-1. The Standard Model processes include QCD, B-physics, diffraction, detailed studies of the top quark properties, and electroweak physics topics such as the W and Z0 boson properties. The production and decay of the Higgs particle is studied for many observable decays, and the precision with which the Higgs boson properties can be derived is determined. About ten different supersymmetry benchmark points are analysed using full simulation. The CMS discovery reach is evaluated in the SUSY parameter space covering a large variety of decay signatures. Furthermore, the discovery reach for a plethora of alternative models for new physics is explored, notably extra dimensions, new vector boson high mass states, little Higgs models, technicolour and others. Methods to discriminate between models have been investigated. This report is organized as follows. Chapter 1, the Introduction, describes the context of this document. Chapters 2-6 describe examples of full analyses, with photons, electrons, muons, jets, missing E T, B-mesons and τ's, and for quarkonia in heavy ion collisions. Chapters 7-15 describe the physics reach for Standard Model processes, Higgs discovery and searches for new physics beyond the Standard Model. © 2007 IOP Publishing Ltd.
Published: 2007
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21. An Error-Correcting Line Encoding ASIC for a HEP Rad-Hard Multi-GigaBit Optical Link

Author: G. Papotti
Subjects: Application-specific integrated circuit, Computer science, Gigabit, Optical link, Encoding (memory), Header, Electronic engineering, Forward error correction, Hardware_ARITHMETICANDLOGICSTRUCTURES, Chip, Error detection and correction
Abstract: This paper presents an ASIC implementing the line encoding scheme to be used in the GBT system, a multi-gigabit optical link designed for use in a high energy physics environment. A general overview of issues specific to optical links placed in radiation environments is given, and the required properties of the line encoding discussed. A scheme that preserves the DC-balance of the line and allows forward error correction is proposed. It is implemented through the concatenation of scrambling, Reed-Solomon error-correction and addition of an 8-bit DC-balanced header. The proposed scheme has been implemented in a fully digital chip fabricated in a 0.13mum CMOS technology. Implementation details and test and simulation results are given
Published: 2006
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22. Poorly differentiated carcinomas of the thyroid with trabecular, insular, and solid patterns: a clinicopathologic study of 183 patients

Author: Stefania Landolfi, Luigi Chiusa, Alessandra Codegone, Bruno Torchio, Nicola Palestini, Manuela Motta, Mauro G. Papotti, and Marco Volante
Subjects: Adult, Male, Cancer Research, medicine.medical_specialty, Pathology, Adenocarcinoma, Scirrhous, poorly differentiated, Adenocarcinoma, carcinoma, insular, thyroid, Thyroid carcinoma, Sex Factors, Poorly Differentiated Thyroid Carcinoma, medicine, Carcinoma, Humans, Thyroid Neoplasms, Thyroid cancer, Aged, Neoplasm Staging, Probability, Retrospective Studies, Analysis of Variance, business.industry, prognosis, Biopsy, Needle, Thyroid, Cancer, Histology, Middle Aged, medicine.disease, Immunohistochemistry, Survival Analysis, Carcinoma, Papillary, Treatment Outcome, medicine.anatomical_structure, Oncology, Case-Control Studies, Multivariate Analysis, Thyroidectomy, Female, Histopathology, business
Abstract: BACKGROUND The term poorly differentiated (PD) carcinoma was proposed 20 years ago to define aggressive, follicular-derived thyroid carcinomas with behavior intermediate between follicular/papillary and anaplastic carcinomas. Among the variable histologic patterns recognized in such tumors, trabecular-insular-solid (TIS) areas usually are predominant. Conversely, some authors pointed out that PD carcinomas are characterized by unequivocal, high-grade histology with atypias, high mitotic counts, and necrosis rather than by a specific growth pattern. METHODS The clinicopathologic features of a series of 183 thyroid carcinomas with predominant (n = 165 tumors) or focal (n = 18 tumors) TIS growth patterns were studied by univariate and multivariate overall survival analyses and were compared with clinical outcomes. Subgroups included tumors with predominant oxyphilic features (n = 66 tumors) and (residual) papillary carcinoma features (n = 24 tumors). Control groups of papillary (n = 68 tumors), follicular (n = 71 tumors), and anaplastic (n = 35 tumors) carcinomas also were included for overall survival analysis. RESULTS TIS carcinomas had an intermediate behavior between papillary/follicular and anaplastic carcinomas (P 45 years (P = 0.007), the presence of necrosis (P 3 per 10 high-power fields (P = 0.01) were associated with poor outcome. A simplified scoring system based on statistically significant parameters allowed the identification of three prognostic subgroups (P < 0.0001). CONCLUSIONS PD TIS carcinomas overall followed a more aggressive course compared with differentiated thyroid carcinomas, irrespective of the extent of the TIS component. However, a numeric scoring system applied to specific clinicopathologic parameters further may identify three prognostic categories of patients who have significantly different survival rates at 5 years and 10 years. Cancer 2004;100:950–7. © 2004 American Cancer Society.
Published: 2004

23. Changes in autonomic nervous function over a 5-year period in non-insulin-dependent diabetic patients

Author: R, Quadri, P, Ponzani, M, Zanone, S, Maule, A, La Grotta, G, Papotti, M, Valentini, C, Matteoda, L, Chiandussi, and D, Fonzo
Subjects: Male, Time Factors, Muscles, Respiration, Posture, Blood Pressure, Middle Aged, Autonomic Nervous System, Hand, Electrocardiography, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Diabetic Neuropathies, Heart Rate, Supine Position, Humans, Female, Longitudinal Studies, Follow-Up Studies
Abstract: One hundred and eight non-insulin-dependent diabetic patients who had been tested for autonomic dysfunction in 1984/85 were re-evaluated 5 years later. Autonomic function was assessed by means of four cardiovascular tests (heart rate variation during deep breathing and standing, and blood pressure variation after standing and sustained handgrip). Eighteen subjects were lost to follow-up; in the 90 patients who completed the study, both the deep breathing and the handgrip test significantly worsened (respectively from 13.7 +/- 7.8 to 11.6 +/- 6.3 beats min-1 p0.01, and from 16.9 +/- 8.2 to 12.7 +/- 7.1 mmHg, p0.001), whereas both the 30:15 ratio and the variation of blood pressure on standing did not change. The impairment of a comprehensive evaluation score (from 2.5 +/- 1.7 to 3.0 +/- 1.5; p0.05) also confirmed the gradual deterioration of autonomic function over the study period.
Published: 1993

24. Left Ventricular Mass Index and Diastolic Function are Major Determinants of Left Atrial Volume in Essential Hypertensive Patients

Author: M. Caserta, Franco Veglio, S. Del Colle, P. Mulatero, D. Naso, G. Papotti, A. Dematteis, Alberto Milan, and Franco Rabbia
Subjects: Left ventricular mass, medicine.medical_specialty, Index (economics), Volume (thermodynamics), Left atrial, business.industry, Internal medicine, Internal Medicine, Cardiology, medicine, Diastolic function, Cardiology and Cardiovascular Medicine, business
Published: 2005
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25. Status of 24H Ambulatory Blood Pressure and Cognitive Function in Asintomatic Essential Hypertensives

Author: Franco Rabbia, Paolo Cerrato, Franco Veglio, J. Zhong, C. Pugni, M. L. Genesia, G. Papotti, Cristina Paglieri, G. Leotta, and P. Mulatero
Subjects: medicine.medical_specialty, Ambulatory blood pressure, business.industry, Internal medicine, Internal Medicine, Cardiology, Medicine, Cognition, Cardiology and Cardiovascular Medicine, business
Published: 2005
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26. Evaluation of Spontaneous Baroreflex Sensitivity (BRS) in Hypertensive Patients

Author: M. Caserta, A. Dematteis, S. Del Colle, G. Papotti, P. Mulatero, Franco Veglio, Franco Rabbia, D. Naso, and Alberto Milan
Subjects: Correlation, business.industry, Anesthesia, Internal Medicine, medicine, Sensitivity (control systems), Baroreflex, Cardiology and Cardiovascular Medicine, medicine.disease, business, Obesity
Published: 2005
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27. Hyper Macondo

Author: Franco Rabbia, Franco Veglio, G. Papotti, D. Naso, P. Mulatero, Alberto Milan, and L. Movio
Subjects: business.industry, Internal Medicine, Medicine, Medical emergency, Cardiology and Cardiovascular Medicine, business, medicine.disease
Published: 2005
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28. Association Between QT Interval and Cardiovascular Risk Factors in Healthy Young Subjects

Author: Franco Rabbia, G. Leotta, G. Papotti, Simona Maule, D. Naso, and Franco Veglio
Subjects: medicine.medical_specialty, business.industry, Internal medicine, Cardiovascular risk factors, Internal Medicine, Cardiology, Medicine, Cardiology and Cardiovascular Medicine, business, Association (psychology), QT interval
Published: 2005
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29. THE TEN YEARS LATER PROJECT

Author: Franco Rabbia, Franco Veglio, Livio Chiandussi, M. Caserta, S. Del Colle, G. Leotta, and G. Papotti
Subjects: Pediatrics, medicine.medical_specialty, Blood pressure, Physiology, business.industry, Internal Medicine, Medicine, Young adult, Cardiology and Cardiovascular Medicine, business
Published: 2004
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30. Left ventricular mass and autonomic tone in obese and hypertensive adolescents

Author: Alberto Milan, Franco Rabbia, Cristina Paglieri, Fulvio Morello, Franco Veglio, Renata Carra, G. Papotti, Barbara De Vito, and T. Grosso
Subjects: medicine.medical_specialty, Megalencephalic leukoencephalopathy with subcortical cysts, business.industry, Autonomic tone, Diastole, medicine.disease, Childhood obesity, Left ventricular mass, Autonomic nervous system, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Cardiology, Heart rate variability, business
Published: 2002
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31. Cardiovascular responsiveness in subjects with severe mental retardation

Author: C. Matteoda, R. Quadri, M. Valentini, Simona Maule, D. Fonzo, C. Marinone, L. Chiandussi, and G. Papotti
Subjects: Physiology, General Neuroscience, Neurology (clinical)
Published: 1993
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32. Poorly differentiated carcinomas of the thyroid with trabecular, insular, and solid patterns.

Author: Marco Volante, Stefania Landolfi, Luigi Chiusa, Nicola Palestini, Manuela Motta, Alessandra Codegone, Bruno Torchio, and Mauro G. Papotti
Published: 2004

33. [Evaluation of diabetic glycemic control in hospital and extra-hospital regimen (author's transl)]

Author: R, Attardo, C, Zanno, S, Gamba, G, Papotti, P L, Barbero, and B, Bruni
Subjects: Adult, Blood Glucose, Male, Diabetes Mellitus, Type 1, Time Factors, Adolescent, Diabetes Mellitus, Methods, Humans, Insulin, Female, Middle Aged, Circadian Rhythm
Abstract: It is suggested an evaluation of the degree of diabetic control in insulin-dependent "difficult" patient, during the period following the discharge from hospital. In 13 cases, the quality of glycemic regulation was compared in intra- and extra-hospital therapeutic regimen by means of 3 new indices of the diurnal blood sugar profile: the Mbs, delta, and Mdelta values. Mbs value describescribes the mean level of the blood sugar curve; delta indicates the amplitidue of the glycemic variability field; Mdelta reports both maximal and minimal extremes of the curve. A combination of the first two parameters proved adequate for a clinical assessment of diabetic control. In the majority of the cases, blood glucose patterns were found similar or even improve in extra-hospital conditions. The insulin dosage ordered during hospital staying was confirmed in all, but one, patients. Psychological approach is probably essential for such good results. The procedure seems to be suitable in order to establish a more correct starting point for an effective treatment of the diabetic out-patient.
Published: 1976

34. [Phenylketonuria. Clinical and medico-social considerations. Our recent experiences]

Author: M T, Gandolfo and G, Papotti
Subjects: Neurologic Manifestations, Time Factors, Pregnancy, Intellectual Disability, Phenylketonurias, Infant, Newborn, Humans, Female, Social Adjustment
Published: 1975

35. [Transport and preservation of biological specimens for microbiological processing (author's transl)]

Author: G, Papotti, E, Capra, and R, Blandamura
Subjects: Bacteriological Techniques, Time Factors, Bacteria, Italy, Humans, Body Fluids, Specimen Handling
Abstract: Here you can read how to carry and preserve the biologic specimens literature speaks about and we found in many Italian hospitals. In particular we explain how to carry and preserve specimens of urine, stool, expectoration, pharyngeal exudate and we speak about the many problems of preserving isolated strains for long time.
Published: 1977

36. [Serum enzyme variations in patients iwth malignant tumors. II. Aldolase]

Author: D, GULLINO, G, PAPOTTI, and L, FERRARA
Subjects: Fructose-Bisphosphate Aldolase, Neoplasms, Humans
Published: 1961

37. [Clinical aspects of bilirubinemia]

Author: R, Bonsi, C, Bianco, and G, Papotti
Subjects: Brain Diseases, Animals, Humans, Jaundice, Bilirubin, Biomarkers, Hyperbilirubinemia
Published: 1967

38. [The eosinophilic granulocyte count in supposedly normal individuals. Statistical findings]

Author: G, Papotti, P F, Sassi, and C, Bianco
Subjects: Adult, Male, Aging, Adolescent, Infant, Newborn, Infant, Middle Aged, Eosinophils, Leukocyte Count, Child, Preschool, Humans, Female, Seasons, Child, Aged
Published: 1967

39. [Current knowledge of experimental chemical crcinogenesis]

Author: R, Bonsi, C, Bianco, and G, Papotti
Subjects: Alkylating Agents, Chemistry, Chemical Phenomena, Benzene Derivatives, Carcinogens, Animals, Neoplasms, Experimental, Amines, Azo Compounds, Hydrocarbons
Published: 1967

40. [Serum enzyme variations in patients with malignant tumors. III. Lactic dehydrogenase]

Author: D, GULLINO, G, PAPOTTI, and L, FERRARA
Subjects: Neoplasms, Oxidoreductases, Lactate Dehydrogenases
Published: 1961

41. [The antistaphylolysin titer in the normal infant]

Author: I, LANZA, R, MORBIDELLI, and G, PAPOTTI
Subjects: Blood, Immunoglobulins
Published: 1956

42. [Dietetic advice]

Author: D, David and G, Papotti
Subjects: Dietary Carbohydrates, Nutritional Requirements, Humans, Water, Avitaminosis, Nutritional Physiological Phenomena, Dietary Proteins, Vitamins, Calorimetry, Sodium Chloride, Dietary Fats, Nutrition Disorders
Published: 1969

43. [Premature newborn child health services]

Author: G, Papotti, P F, Sassi, and C, Bianco
Subjects: Italy, Child Health Services, Infant Care, Infant, Newborn, Child Welfare, Humans, Hospitals, Special, Infant, Premature
Published: 1966

44. [Problems regarding the pathology and functional correlations of the anterior pituitary gland]

Author: R, Bonsi, C, Bianco, and G, Papotti
Subjects: Pituitary Hormones, Anterior, Pituitary Diseases, Pituitary Gland, Humans, Pituitary Neoplasms
Published: 1967

45. [The organization of a Center for the aged]

Author: G, Papotti, P F, Sassi, and C, Bianco
Subjects: Italy, Geriatrics, Chronic Disease, Homes for the Aged, Humans, Hospitals, Aged, Nursing Homes
Published: 1967

46. [Statistical considerations on glycemia in supposedly normal persons]

Author: G, Papotti
Subjects: Blood Glucose, Humans
Published: 1967

47. [Determination of anti-chymotrypsin activity of the blood serum of patients with malignant tumors; West-Hillard test]

Author: L, GUIDETTI, G, PAPOTTI, and E, PUGNANI
Subjects: Serum, Neoplasms, Chymotrypsin, Humans, Protease Inhibitors
Published: 1956

48. [Antistreptolysin-O titre in rheumatic diseases of children treated with cortisone and prednisone]

Author: I, LANZA, R, MORBIDELLI, and G, PAPOTTI
Subjects: Cortisone, Rheumatic Diseases, Streptolysins, Humans, Prednisone, Steroids, Rheumatic Fever, Antistreptolysin
Published: 1956

49. [Value and interpretation of hepatic function tests]

Author: C, Bianco, R, Bonsi, and G, Papotti
Subjects: Cholesterol, Liver Function Tests, Bile, Humans, Proteins, Bilirubin, Ketone Bodies, Blood Protein Electrophoresis, Lipid Metabolism, Phospholipids
Published: 1967

50. [Considerations on some metabolic changes in lithiasic cholecystopathy]

Author: F, VIDILI, L, FERRARA, G, PAPOTTI, and D, GULLINO
Subjects: Cholelithiasis, Humans
Published: 1961

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